Author: Chen-Ju Feng, Shih-Ming Hsu, Chin-Hsiung Lin, Shih-Yong Luo, Shao-Chun Tseng, Chin-Hui Wu, Ya-Ru Yang ðĻâðŽ
Affiliation: National Yang Ming Chiao Tung University, Koo Foundation Sun Yat-Sen Cancer Center, Tzu-Chi University, NanoRay Biotech Co., Ltd ð
Purpose: The range of auger electrons in water is 2~500 nm, and its linear energy transfer reaches 26 keV/Ξm. This study investigated the feasibility of the auger electron radiation therapy.
Methods: A transmission-target X-ray system used in this experiment was a NanoRay Biotech NM series. The spectrometer used in this experimentwas an Amptek X-123. This study adopted the PTW Markus 23343 parallel plate ionization chamber to measure flatness and symmetry in the PTW MP3-s water tank. This study used a Monte Carlo simulation program to explore the feasibility of auger electron radiotherapy as a new type of radiotherapy for cancer treatment.
Results: The special designed thin targets of the transmission-target Xray tube can generate more characteristic radiation output. The measurement values obtained by the spectrum meter, chamber, and Monte Carlo simulations were in good agreement. The results reveal that the auger electron yield increases when transmission X-ray tubes are combined with radiosensitizers.
Conclusion: Monte Carlo simulation results show that photons, secondary electrons, and auger electron can deposit doses in the cells. Therefore, it is estimated that auger electron radiotherapy is feasible in the treatment of cancer.