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Results for "Damodar Pokhrel": 12 found

A Novel Sphere Packing Solution Via Principal Component Analysis for Lattice SFRT Treatment of Large, Bulky, and Unresectable Tumors

Authors: James Robert Castle, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: We propose a novel methodology for lattice deployment in spatially fractionated radiotherapy (SFRT), using principal component analysis (PCA) to improve sphere packing within the tumor. Impro...

Automated Treatment Planning for Linac-Based Stereotactic Radiosurgery of Intraocular Malignancies Via Hyperarc Knowledge-Based Planning

Authors: Chase Cochran, Shane McCarthy, Damodar Pokhrel, William St Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Manually generating intraocular stereotactic radiosurgery (SRS) plans involves significant challenges, including lengthy planning times and inter-planner variability. Knowledge-based SRS plan...

Automated Treatment Planning for Stereotactic Recurrent Head and Neck Cancers Using Knowledge-Based Planning, Multicriteria Optimization, and Dosimetric Scorecards

Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Demonstration of automated stereotactic treatment planning for recurrent head and neck (RHN) cancers using knowledge-based planning, multicriteria optimization (MCO), and dosimetric scorecard...

Clinical Outcomes of Gamma Knife Stereotactic Radiosurgery Treatments for Intracranial Arteriovenous Malformations & Fistulas: A Single Institutional Retrospective Study

Authors: Madeleine Arbogast, David Dorndos, Denise E Foltz, Justin Fraser, Damodar Pokhrel, William St Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Department of Neurosurgery, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: For stereotactic radiosurgery (SRS) treatments of intracranial arteriovenous malformations (AVM) and fistulas (AVF), same-day Leksell Gamma Knife (GK) is the preferred modality. Long-term cli...

Development and Clinical Validation of Hyperarc Stereotactic Radiosurgery Method for Intraocular Tumors

Authors: Chase Cochran, Damodar Pokhrel, William St Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Currently, intraocular disease is primarily treated via COMS-plaques brachytherapy. Various stereotactic approaches via photons/proton beam have also been implemented (CyberKnife/GammaKnife/p...

Development and Clinical Validation of a Tissue Maximum Ratio (TMR)-Based Monitor Units Second Check Script for Dynamic Conformal-Based Hyperarc Brain Radiosurgery Plans Via Scatter Correction Factors

Authors: Jacob Gooslin, Ellis Lee Johnson, Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: HyperArc radiosurgery permits treatment of multiple brain lesions using a single-isocenter improving treatment planning efficiency and workflow. A key stereotactic planning aspect is an indep...

Differential Hole-Size Lattice Patterns for Escalating SFRT Dose to Large, Deep-Seated, and Unresectable Masses

Authors: Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumor’s center, surrounded by smaller diameter spheres. W...

Presenting a Novel Treatment Scheme for Debulking Unresectable Large Tumors: Feasibility, Safety and Patient Reported Early Clinical Outcomes of SBRT Immediately Post-Spatially Fractionated Radiotherapy Delivery

Authors: James Knight II, Joshua Misa, Damodar Pokhrel, William St Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Highly-heterogenous sieve-like dose distribution via SFRT to large/bulky tumors (≥6 cm) could enhance tumor cell-death via both direct/indirect cell-kill mechanisms. Adding highly-conformal S...

Robust and Radiobiologically Accurate Dose Summation Strategy for Multiple Courses of Stereotactic Re-Irradiation of Metastatic Brain Cancer Patients with Previous WBRT

Authors: Garrett Russell Hamilton, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Recurrent brain metastasis is very common, and patients who previously received whole-brain radiotherapy (WBRT) may receive an additional course(s) of stereotactic radiosurgery (SRS) to selec...

Stereotactic Body Radiosurgery for Refractory Ventricular Tachycardia: Presenting Efficient Clinic Workflow, Dosimetric Analysis and Patients Reported Clinical Results

Authors: Karam Ayoub, Aaron B Hesselson, Ronald C McGarry, Joshua Misa, Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Department of Cardiology

Abstract Preview: Purpose: Noninvasive stereotactic body radiosurgery (SBRS) is emerging treatment option for advanced heart failure patients with refractory-ventricular tachycardia (rVT) who experienced recurrent impl...

The Role of Radiosurgery to Vascular Anomalies Such As Arteriovenous Malformations (AVMs)

Authors: Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: N/A...

Tumor Dose Escalation for Recurrent Head and Neck SRT Via a Hyperarc-Based Rapidplan Model

Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Demonstrating the feasibility of dose escalation for stereotactic recurrent head and neck (RHN) cancers through the deployment of a Hyper-Arc Based RapidPlan (HARP) model through an Eclipse S...