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A Deep Learning Method for Direct Vmi Inference Using a Dual-Layer Radiotherapy Kv-CBCT Imager

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: A challenge for dual energy CBCT is that noise and residual errors in material decomposition steps can become amplified when forming low energy, high contrast virtual mono-energetic images (V...

A Hybrid Radiomics-Integrated Machine Learning Framework for Early Identification of Potential Radiation Pneumonitis in Lung Cancer Patients

Authors: Christos Ilioudis, Marios Myronakis, Sotirios Raptis, Kyriaki Theodorou

Affiliation: Medical Physics Department, Medical School, University of Thessaly, Department of Information and Electronic Engineering, International Hellenic University (IHU)

Abstract Preview: Purpose: This study presents a radiomics-driven, machine learning framework developed to predict the possibility of Radiation Pneumonitis (RP), as a side effect of radiation therapy in lung cancer pat...

A Novel Integrated Framework for Rapid Automatic Calculation of Organ Absorbed Dose from kV-CBCT Imaging during Radiotherapy

Authors: Marios Myronakis, Kyriaki Theodorou

Affiliation: Medical Physics Department, Medical School, University of Thessaly

Abstract Preview: Purpose: The development of an integrated application framework for rapid, seamless, and automated calculation of absorbed organ dose for individual patients undergoing kV CBCT imaging over the course...

A Novel Linac Onboard Dual-Layer Kv Imager Provides Increased Clinical CBCT Contrast and Metal Artifact Reduction Using Virtual Monoenergetic Images

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Dual-energy imaging offers benefits, including metal artifact reductions (MAR) and improved contrast, that enhance visualization. Currently, dual-energy imaging is largely limited to CT scann...

An Analytical Framework to Quantify the Effect Obstructing Anatomical Features in Intrafractional Spectral Imaging Using a Dual-Layer Kv Imager

Affiliation: Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory

Abstract Preview: Purpose:
Dual-layer kV imager (DLI) architecture enables the capability for single-shot dual-energy (DE) intrafraction imaging. As noise from individual DLI layers are primarily uncorrelated, simpl...

Geometric Alignment of MV-CBCT and Dual-Layer Kv-CBCT Projections Using Deep Learning

Abstract Preview: Purpose: Applications of combined kV-MV CBCT include metal artifact correction and material identification. Difficulties arise, however, when the imagers have misaligned geometric perspectives of the ...

Integrating Radiomics and ADC Ratio for Multicenter Prostate Cancer Diagnosis: A Harmonized Machine Learning Approach

Authors: George Agrotis, Marios Myronakis, Dimitrios Samaras, Kyriaki Theodorou, Ioannis Tsougos, Vassilios Tzortzis, Maria Vakalopoulou, Alexandros Vamvakas, Aikaterini Vassiou, Marianna Vlychou

Affiliation: Medical Physics Department, Medical School, University of Thessaly, Department of Radiology, University of Thessaly, Netherland Cancer Institute, Department of Urology, University of Thessaly, CentraleSupelec, University Paris-Saclay

Abstract Preview: Purpose: Prostate cancer (PCa) diagnosis remains challenging due to discrepancies in Gleason Scoring (GS) and risks of overdiagnosis and underdiagnosis. Multiparametric MRI (mpMRI), including Apparent...

Nausea, Heartburn, K-Edge Imaging: Pepto Bismol As a CT Contrast Agent

Authors: Magdalena Bazalova-Carter, Ross I. Berbeco, James Day, Xinchen Deng, Chelsea Amanda Saffron Dunning, Dianne M. Ferguson, Matthew W. Jacobson, Toby Morris, Marios Myronakis, Jericho Daniel O'Connell, Fides Schwartz, Jainil Shah, Aaron Sodickson

Affiliation: Brigham and Womens Hospital, University of Massachsetts Lowell and Dana-Farber Cancer Institute Boston, Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, University of Washington, University of Victoria, Siemens Healthineers, Dana Farber/Brigham and Women's Cancer Center, Brigham and Women's Hospital

Abstract Preview: Purpose: While CT imaging has advanced with improved machine design, we propose further gains can be achieved by enhancing sensitivity to contrast agents. Current CT sensitivity is limited to 1% bismu...

Optimizing Design to Enhance the Energy Separation in a Kv Dual-Layer Imager (DLI)

Abstract Preview: Purpose: Multi-layer flat-panel imagers can improve for clinical image-guided radiotherapy applications, including the enhanced visualization of soft tissue and a reduction in image artifacts. Each im...

Organ Dose Estimation from Successive CBCT Imaging for Patients Undergoing Radiation Therapy for Prostate Cancer

Authors: Panagiotis Iliopoulos, Marios Myronakis, Kyriaki Theodorou