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Results for "Mu-Han Lin": 246 found

4D CBCT Reconstruction Using Denoising Diffusion Implicit Models

Authors: Weixing Cai, Laura I. Cervino, Yabo Fu, Bohong Huang, Licheng Kuo, Tianfang Li, Xiang Li, Jean M. Moran, Huiqiao Xie, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Four-dimensional cone-beam computed tomography (4D-CBCT) is critical in image-guided radiotherapy (IGRT) for visualizing tumor motion. However, sparse projection sampling often introduces sev...

A 2D Discrete Ionization Chamber Array for Proton Pencil Beam Scanning Flash Dosimetry

Authors: Fu-Xiong Chang, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Nancy Y Lee, Chih-Hsun Lin, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Pingfang Tsai, Shouyi Wei, Irini Yacoub, Yunjie Yang, Ajay Zheng, Jun Zhou

Affiliation: New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Liverage Biomedical Inc., Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Institute of Physics, Academia Sinica

Abstract Preview: Purpose: FLASH therapy presents an opportunity to alter the radiotherapy paradigm and significantly enhancing normal organ protection while maintaining the effectiveness of tumor control. The temporal...

A Causal Machine Learning Analysis of Dosimetric and Clinical Predictors of Osteoradionecrosis in Head and Neck Cancer Radiotherapy

Authors: Jingyuan Chen, Sheng Li, Tianming Liu, Wei Liu, Zhengliang Liu, Zhong Liu, Daniel Ma, Samir H. Patel, Guangya Wang, Yunze Yang

Affiliation: University of Miami, Mayo Clinic, School of Data Science, University of Virginia, School of Computing, University of Georgia, Department of Radiation Oncology, Mayo Clinic, Institute of Western China Economic Research, Southwestern University of Finance and Economics

Abstract Preview: Purpose:
Traditional patient outcome analyses relied heavily on conventional statistical models that primarily elucidate correlation rather than causal relationships. In this study, we aim to ident...

A Clarification on the Bandwidth Difference Method for MRI B0 Homogeneity Assessment

Authors: Christina Brunnquell, Daniel Vergara, Joseph Everett Wishart

Affiliation: University of Minnesota, University of Washington

Abstract Preview: Purpose: To propose and validate a correction to the bandwidth difference method presented in Task Group Report No. 325 for quantifying static magnetic field homogeneity (ΔB0).
Methods: A clarifica...

A Comparative Analysis of Hand Calculations and Macro Monte Carlo Simulations for Electron Beam Dosimetry

Authors: Mohamed Eldib, Adam Mahl, Moyed Miften, Rachel Petragallo, Kelly L. Stuhr

Affiliation: University of Colorado - Anschutz Medical Campus, University of Colorado School of Medicine, University of Colorado Denver, Department of Radiation Oncology, University of Colorado

Abstract Preview: Purpose: To compare electron beam dose calculations performed manually with those computed using the Macro Monte Carlo simulation for standard fields on both phantom and patient setups, with the aim o...

A Dosimetric Investigation into the Potential of Aperture-Based Techniques to Improve the Clinical Outcomes of Single-Energy Proton Bragg Peak Flash Therapy for Ocular Cancers

Authors: Arpit M. Chhabra, J Isabelle Choi, Minglei Kang, Haibo Lin, Hang Qi, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Xingyi Zhao, Ajay Zheng

Affiliation: New York Proton Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Pencil beam scanning (PBS) proton therapy effectively treats ocular cancer by minimizing exit doses to normal tissues. However, challenges remain in sparing nearby organs-at-risk(OARs). Ul...

A Dual Energy CT-Guided Intelligent Radiation Therapy Platform

Authors: Jiayi Chen, Manju Liu, Ning Wen, Haoran Zhang, Yibin Zhang

Affiliation: Department of Radiation Oncology, Ruijin Hospital, Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Duke Kunshan University, Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Abstract Preview: Purpose: This study introduces a novel Dual Energy CT (DECT)-Guided Intelligent Radiation Therapy (DEIT) platform designed to streamline and optimize the radiotherapy process. The DEIT system combines...

A Method to Expedite Quality Assurance for Head and Neck Ctvs with Lymph Node Level Auto-Autocontouring and Identification

Authors: Beth M. Beadle, Adrian Celaya, Laurence Edward Court, David Fuentes, Anna Lee, Tze Yee Lim, Dragan Mirkovic, Amy Moreno, Raymond Mumme, Tucker J. Netherton, Callistus M. Nguyen, Jaganathan A Parameshwaran, Jack Phan, Carlos Sjogreen, Sara L. Thrower, Congjun Wang, He C. Wang, Xin Wang

Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Radiation Oncology, Stanford University, The University of Texas MD Anderson Cancer Center, MD Anderson Cancer Center, MD Anderson, Rice University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Quality assurance of target volumes from radiotherapy clinical trials is a labor and resource intensive task. The purpose of this work is to quantify the accuracy of a tool that automatically...

A Multimodal CAD System for Breast Cancer Detection: Integrating MRI, DBT, and Mammography for Dense Breast Challenges

Authors: Si-Wa Chan, Yuan-Yu Lee, Zhi-Ying Li, Jia-Wei Liao, Hui-Yu Cathy Tsai

Affiliation: Department of Radiology, Taichung Veterans General Hospital​, Institute of Nuclear Engineering and Science, National Tsing Hua University

Abstract Preview: Purpose: Dense breast tissue reduces the sensitivity of mammography, posing diagnostic challenges, especially for Asian women with high breast density (up to 50%). Current single-modality techniques o...

A Novel Abdominal Phantom with Deformable Organs

Authors: Katherine Brown, Will Buchsbaum, Mylinh Dang, Joshua Dean, Sameer Faruquee, Gracie Huff, Claudia Maldonado, Gaby Min, David O'Neill, Gemily Wang, Poonam Yadav

Affiliation: Northwestern University, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Northwestern Medicine

Abstract Preview: Purpose:
To establish an abdominal imaging phantom that includes deformable organs including the stomach, duodenum, and pancreas. This phantom will be used in routine calibration of an MRI-LINAC sy...

A Novel Lattice Technique Based Spot Scanning Proton Arc Therapy Via Spot Sparsity Optimization and LET Optimization

Authors: Zhitao Dai, Riao Dao, Xuanfeng Ding, Qingkun Fan, Yajun Jia, Gang Liu, Gang Peng, Yujia Qian, Hong Quan, Kunyu Yang, Sheng Zhang, Lewei Zhao

Affiliation: Department of Radiation Oncology, Stanford University, Corewellhealth William Beaumont University Hospital, School of Mathematics and Statistics, Wuhan University, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Chinese Academy of Medical Sciences Cancer Hospital Shenzhen Hospital, School of Physics and Technology,Wuhan University, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose: Lattice radiation therapy (LRT) is an innovative three-dimensional(3D) implementation type of spatially fractionated radiation therapy (SFRT). This study aims to develop a novel spot-scanning...

A Novel Proton Lattice Modality Using Minibeams

Authors: Hao Gao, Yuting Lin, Nimita Shinde, Weijie Zhang

Affiliation: Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: LATTICE, a form of spatially fractionated radiation therapy (SFRT), delivers high-dose peaks and low-dose valleys to the target volume and has been clinically used for large target volumes. H...

A Novel Semi-Analytic Approach for Dose Calculation in Proton Minibeam Radiotherapy

Authors: Hao Gao, Wangyao Li, Yuting Lin, Chao Wang, Wei Wu

Affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Proton minibeam radiation therapy (pMBRT) delivers a unique peak-and-valley dose pattern using collimators with narrow slits, offering improved normal tissue sparing compared to conventional ...

A Pilot Study to Implement a Definitive Breast SBRT Technique

Authors: Charmainne Cruje, Maria Dumol, Nawroz Fatima, Marisa Finlay, Kalaina Johnson, Raman Mohla, Jasleen Uppal

Affiliation: Trillium Health Partners, Carlo Fidani Regional Cancer Centre

Abstract Preview: Purpose: To evaluate the robustness of a breast SBRT protocol in achieving target coverage by utilizing online- and retrospectively-matched CBCT-to-CT images.
Methods: The first pilot patient was s...

A Radiomic Quantification Framework for Hyperparameter Optimization in Texture Characterization

Authors: Yuli Lu, Chendong Ni, Cheng Qian, Kun Qian, Weiwei Sang, Chunhao Wang, Fan Xia, Zhenyu Yang, Fang-Fang Yin, Rihui Zhang, Haiming Zhu

Affiliation: Jiahui International Hospital, Radiation Oncology, Duke University, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, The First People's Hospital of Kunshan

Abstract Preview: Purpose: To develop a radiomic quantification framework to evaluate the effects of radiomic image preprocessing hyperparameters (i.e., image resampling and discretization) on texture characterization ...

A Real-Time 6 Degrees-of-Freedom Image Guided Radiation Therapy Technology Using Internal-External Motion Correlation Modelling

Authors: Jeremy T. Booth, Nicholas Hardcastle, Freeman Jin, Alicja Kaczynska, Paul J. Keall, Chandrima Sengupta

Affiliation: Northern Sydney Cancer Centre, Royal North Shore Hospital, Physical Sciences, Peter MacCallum Cancer Centre, Image X Institute, Faculty of Medicine and Health, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney

Abstract Preview: Purpose: An ESTRO survey reported that 71% of radiotherapy centers across 41 countries want to implement real-time image guided radiation therapy (IGRT) to improve patient outcomes. To address this gl...

A Retrospective Assessment of Proton Radiation Response in Brain Tumor Patients Using Diffusion-Weighted MR Imaging

Authors: Liu Hong, Wen C. Hsi, Faraz Kalantari, Romy Megahed, Ganesh Narayanasamy, Maida Ranjbar, Pouya Sabouri, Zhong Su

Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)

Abstract Preview: Purpose: Quantitative apparent diffusion coefficients (ADC) in diffusion-weighted MRI (dMRI) reflect water diffusivity and thus provide tissue cellular density information. Functional diffusion mappin...

A Setup and Workflow for Fully Automated Electromagnetic Tracking-Based Implant Reconstruction in Intraoperative Prostate HDR Brachytherapy

Authors: Ioannis Androulakis, Miranda E.M.C. Christianen, JƩrƩmy Godart, Mischa Hoogeman, Inger-Karine K. Kolkman-Deurloo, Lorne Luthart, Remi A. Nout, Henrike Westerveld

Affiliation: Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands, Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam

Abstract Preview: Purpose:
Despite the advantages of transrectal ultrasound-based treatment planning for HDR prostate cancer brachytherapy which allows on-line treatment delivery in the intraoperative setting, it is...

AI Implementation in Radiation Oncology Should be Strictly Regulated

Authors: Mu-Han Lin

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: The rapid expansion of AI in Radiation Oncology is reshaping patient care, treatment planning, and institutional investments. Yet, with no standardized framework for evaluating cost-effectiveness, saf...

AI-Based Registration-Free 3T T2-Weighted MRI Synthesis Using Truefisp MRI Acquired on a 0.35T MR-Linac System

Authors: Hilary P Bagshaw, Mark K Buyyounouski, Cynthia Fu-Yu Chuang, Yu Gao, Dimitre Hristov, Lianli Liu, Lawrie Skinner, Lei Xing

Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University

Abstract Preview: Purpose:
MR-guided radiation therapy has introduced a significant leap in cancer treatment by allowing adaptive treatment. The low-field MR-guided system predominantly uses the TrueFISP sequence, w...

Accuracy Analysis of "Sphere-Mask" Optical Positioning System in Radiotherapy of Breast Cancer

Authors: Xiu tong Lin, Tao Sun

Affiliation: Department of Radiation physics and technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Radiation physics and technology, Shandong Second Provincial General Hospital

Abstract Preview: Purpose: To compare the positioning accuracy and time efficiency of "Sphere-Mask" Optical Positioning System (OPS) and traditional laser light positioning method in breast cancer radiotherapy, and to ...

Achieving Consistent Calcium Score in Lung Cancer Screening: Influence of Cardiac Phases

Authors: Emi Ai Eastman, Chao Guo, Christina Lee, Xinhua Li, Alexander W. Scott, Yifang (Jimmy) Zhou

Affiliation: Cedars-Sinai Medical Center

Abstract Preview: Purpose:
Smoking is one of the risk factors for coronary artery disease. It is desirable to estimate the coronary artery calcification (CAC), a key biomarker for atherosclerosis and cardiovascular ...

Adapting Newer Treatment Planning Strategy for Uveal Melanoma Cases Using Gamma Knife Radiosurgery

Authors: Deepak Agrawal, Subhash Gupta, Shashanksharad Kale, Gopishankar Natanasabapathi, Manoj Phalak, Dhanabalan Rajasekaran, Surendra Kumar Saini, Subramani Vellaiyan

Affiliation: All India Institute of Medical Sciences (AIIMS), All India Institute of Medical Sciences

Abstract Preview: Purpose:
To evaluate planning strategy for uveal melanoma tumor (UM) in gamma knife stereotactic radiosurgery (GKSRS) using Lightning inverse planning software for treatment planning.
Methods:

Advanced Daily Imaging Technology Improves Tracking of Soft Tissue Decomposition for Head and Neck Cancer Patients Receiving Radiotherapy

Authors: Robert K Chin, Klea Hoxha, Erika Jank, Jesus Juarez, Eulanca Yuka Liu, Dylan P. O'Connell, X. Sharon Qi, Ricky R Savjani

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California, Los Angeles, UCLA Radiation Oncology

Abstract Preview: Purpose:
Daily cone beam CT (CBCT) images are acquired prior to each radiotherapy treatment for verifying patient positioning. HyperSight is an advanced imaging solution that replaces standard CBCT...

An Adaptive Radiotherapy Approach Sparing Preirradiated Critical Structures

Authors: Mohamed Bahaaeldin Mohamed Afifi, Lili Chen, Xiaoming Chen, Ahmed A. Eldib, Chang Ming Charlie Ma, Robert A. Price

Affiliation: Fox Chase Cancer Center, Radiological Sciences and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University.

Abstract Preview: Purpose: Reirradiation of recurrent cancer or a newly developed lesion in a proximal location poses a challenge for radiation treatments. This is occasionally encountered in many modern clinics and ef...

An Adaptive Radiotherapy Strategy Study Based on Segmented Synthesis and Deformational Registration

Authors: Jie Hu, Zhengdong Jiang, Nan Li, Tie Lv, Yuqing Xia, Shouping Xu, Gaolong Zhang, Wei Zhao, Changyou Zhong

Affiliation: School of Physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Radiotherapy Department of Meizhou People’s Hospital (Huangtang Hospital), UT Health San Antonio, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, Peopleʼs Republic of China, Department of Radiation Oncology

Abstract Preview: Purpose: Patients usually undergo cone-beam computed tomography (CBCT) scans which are used for patient set-up before radiotherapy. However, the low image quality of CBCT hinders its use in adaptive r...

An Analytical Approach to Monitor Unit Calculation in Extended Distance Total Body Irradiation (TBI)

Authors: Cheewai Cheng, Indra J. Das, Jeffrey Yui Hei Wong, Poonam Yadav

Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine

Abstract Preview: Purpose: Radiation treatment machine replacement brings chaos and urgency of timely completion of machine commissioning for every procedure used including TBI that are time consuming. Based on past ex...

An Automated Approach to Monitoring Clinical Protocols Against a Master Protocol

Authors: Jeremy Christophel, Zhihua Qi

Affiliation: Henry Ford Health

Abstract Preview: Purpose: To demonstrate a method to compare DICOM metadata from clinical scanners with institutional protocols as validation that clinical use matches the master protocol.
Methods: DICOM metadata i...

An Automated Notification System for Identifying Patients Eligible for Biology-Guided Radiotherapy

Authors: Shahed Badiyan, Bin Cai, Tu Dan, Michael Dohopolski, Steve B. Jiang, Deepkumar Mistry, Arnold Pompos, Robert Timmerman, Jing Wang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Biology-guided radiotherapy (BGRT) offers significant potential for personalized and adaptive cancer treatment, with clinically available systems such as SCINTIX from Reflexion now being intr...

An End-to-End Test for Adaptive Radiotherapy with Varian Hypersight CBCT Imaging System Using Radiochromic Film in a Rando Pelvis Phantom

Authors: Jameson T. Baker, Yijian Cao, Jenghwa Chang, Sean T Grace, Lyu Huang, Jian Liu, Echezona Simon Obi, Anurag Sharma

Affiliation: Northwell, Hofstra University Medical Physics Program

Abstract Preview: Purpose:
To validate the end-to-end dosimetrical accuracy of Varian HyperSight CBCT for adaptive radiotherapy (ART), from simulation to dose delivery, using radiochromic film dosimetry in a Rando p...

An Energy Layer Optimization Approach for Spot Scanning Proton Arc Therapy

Authors: Wenhua Cao, Hadis Moazami Goudarzi, Madison Emily Grayson, Zongsheng Hu, Gino Lim, Steven Hsesheng Lin, Radhe Mohan

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Industrial Engineering, University of Houston, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Proton Arc Therapy (PAT) offers significant potential in treating complex cancer cases by delivering a continuous radiation dose as the gantry rotates. This study aims to investigate the pote...

An Explainable Classifier for Enhancing the Quality Assurance of Digital Breast Tomosynthesis Phantom Images

Authors: Hui-Shan Jian, Yu-Ying Lin

Affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou

Abstract Preview: Purpose: The image quality assurance of mammographic images is crucial for correct diagnosis. To develop and validate an explainable deep-learning classifier for phantom image quality assessment of di...

Analysis of Structure Errors in Region of Interest Contouring for Radiotherapy Planning: A Study Using the RT-Contour QA Platform

Authors: Sijuan Huang, Zi LIU, Jing MA, Xin Yang

Affiliation: Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, 510060, China

Abstract Preview: Purpose: To reduce the pressure of manual review of abnormal situations in manually/automatically delineated regions of interest (ROI), improve its accuracy and basis.
Methods: 220 radiotherapy pat...

Artificial Intelligence-Powered Conventional Energy Integrating Detector-Based Coronary CT Angiography: Learning High-Resolution and Multi-Energy Imaging from Photon-Counting Detector CT

Authors: Shaojie Chang, Thomas A. Foley, Hao Gong, Emily Koons, Shuai Leng, Cynthia H. McCollough, Eric E. Williamson

Affiliation: Mayo Clinic

Abstract Preview: Purpose: To enhance coronary CT angiography (cCTA) capabilities on conventional energy integrating detector CT (EID-CT) using artificial intelligence (AI). The AI framework incorporates high-resolutio...

Assessing Weekly Parotid Gland Shrinkage and Predicting Acute Xerostomia Via an Automated Watchdog in Adaptive Radiotherapy Environment of Head and Neck Cancer

Authors: Eric Aliotta, Michalis Aristophanous, Laura I. Cervino, Yu-Chi Hu, Nancy Y Lee, Anyi Li, Jung Hun Oh, Teeradon Treechairusame, Pengpeng Zhang

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To automatically monitor weekly anatomical changes of parotid glands during adaptive radiotherapy of head and neck cancers, systematically assess the relationship between parotid gland shrink...

Assessing the Feasibility of LD-V1 Film for Annual Kilovoltage Imaging Dose Measurements

Authors: Maria F. Chan, Seng Boh Gary Lim, Shih-Chi Lin, Dustin W. Lynch, Usman Mahmood, Jeonghoon Park

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To explore the feasibility of using GafChromic LD-V1 film for annual imaging dose assessment across kV radiography, fluoroscopy, and cone beam computed tomography (CBCT) imaging protocols, as...

Assessing the Risks of Synthetic MRI Data in Deep Learning: A Study on U-Net Segmentation Accuracy

Authors: Chuangxin Chu, Haotian Huang, Tianhao Li, Jingyu Lu, Zhenyu Yang, Fang-Fang Yin, Tianyu Zeng, Chulong Zhang, Yujia Zheng

Affiliation: The Hong Kong Polytechnic University, Nanyang Technological University, Australian National University, Medical Physics Graduate Program, Duke Kunshan University, North China University of Technology, Duke Kunshan University

Abstract Preview: Purpose: Deep learning segmentation models, such as U-Net, rely on high-quality image-segmentation pairs for accurate predictions. However, the recent increasing use of generative networks for creatin...

Assessment of Automated Planning Templates for Genitourinary and Gastrointestinal Disease Sites for Online MR-Guided Adaptive Radiotherapy

Authors: Shahed Badiyan, Tsuicheng D. Chiu, Viktor M. Iakovenko, Steve Jiang, Christopher Kabat, Mu-Han Lin, Roberto Pellegrini, Arnold Pompos, Edoardo Salmeri, David Sher, Sruthi Sivabhaskar, Justin D. Visak

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, Global Clinical Science, Elekta AB, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Adaptive treatment planning requires robust strategies to enable streamlined on-couch processes, creating a significant barrier for planners transitioning from conventional to adaptive planni...

Assessment of Deep Learning Models for 3D Dose Prediction in Prostate Cancer SIB-IMRT Using MR-Linac

Authors: Hao-Wen Cheng, Jonathan G. Li, Chihray Liu, Wen-Chih Tseng, Guanghua Yan

Affiliation: University of Florida

Abstract Preview: Purpose: This study develops and evaluates deep learning (DL) models for predicting 3D dose distributions in simultaneous integrated boost (SIB) prostate cancer treatment using the Elekta Unity MR-Lin...

Assessment of Plan Quality Metrics for Iroc Houston SRS Phantom Performance Evaluation

Authors: Derek Matthew Garcia, Mallory Glenn, Stephen F. Kry, Ruitao Lin, Dennis S. Mackin, Tucker J. Netherton

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, University of Texas’ MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Houston

Abstract Preview: Purpose: This study aims to investigate the feasibility of implementing clinically relevant quality metrics for evaluating IROC SRS phantom plans, including conformity index (CI) and homogeneity index...

Assessment of Radiation Protection Knowledge Among Operation Professional Nurses

Authors: Yu-Ying Lin

Affiliation: Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou

Abstract Preview: Purpose: This study aimed to evaluate the level of radiation protection knowledge among operating room professional nurses.

Methods: A questionnaire was distributed to operating room profession...

Asymmetrical High Performance Brain Dedicated PET System: Design Optimization and Performance Evaluation

Authors: Yuemeng Feng, Hamid Sabet

Affiliation: Massachusetts General Hospital, Harvard Medical School

Abstract Preview: Purpose: We propose a novel brain-dedicated PET system comprising elliptical cylinder with a neck cut-out, supplemented by front and back panels to improve sensitivity and line-of-response sampling. T...

BEST IN PHYSICS IMAGING: Cross-Contrast Diffusion: A Synergistic Approach for Simultaneous Multi-Contrast MRI Super-Resolution

Authors: Yifei Hao, Wenxuan Li, Xiang Li, Tao Peng, Yulu Wu, Fang-Fang Yin, Yue Yuan, Lei Zhang, Yaogong Zhang

Affiliation: Duke University, School of Future Science and Engineering, Soochow University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: Diffusion-based deep-learning frameworks have been recently used in MRI resolution enhancement, or super-resolution. Multi-contrast MRI share common anatomical structures while holding comple...

BEST IN PHYSICS RADIOPHARMACEUTICALS, THERANOSTICS AND NUCLEAR MEDICINE: The Development and Validation of an in-Vitro Alpha Irradiation Platform with Versatile Radiation Control

Authors: Md Mainul Abrar, Harsh Arya, Yujie Chi, Yijing Liu, Joshua Rajan, Pan Zui

Affiliation: University of Texas at Arlington, The University of Texas at Arlington, Department of Physics, University of Texas at Arlington

Abstract Preview: Purpose: Understanding the biological effects of alpha radiation at varying dose rates and energies is essential for advancing therapeutic strategies. This study demonstrates the capabilities of an in...

BEST IN PHYSICS THERAPY: Fast and Convenient Proton Pencil Beam Energy QA with Multi-Layer Faraday Cup (MLFC)

Authors: Paul Boisseau, Eric S. Diffenderfer, Andrew Friberg, Wenbo Gu, Matthew Nichols, Kan Ota, Xiaokun Teng, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou

Affiliation: Department of Radiation Oncology, University of Pennsylvania, Pyramid Technical Consultants, Inc., University of Pennsylvania

Abstract Preview: Purpose: Traditional quality assurance procedures for proton pencil beam energies involve water tank setups or multiple solid water phantoms and are time-consuming. This study demonstrates that an inn...

BEST IN PHYSICS THERAPY: Overcoming Challenges in Developing Machine Learning-Driven Acute Kidney Injury Predictive Models Using Non-Standard Emrs in Resource-Limited Settings

Authors: Yuanhan Chen, Ziqiang Chen, Qi Cheng, Feng Ding, Rui Fang, Shengwen Guo, Li Hao, Qiang He, Haiquan Huang, Yu Kuang, Xinling Liang, Yuanjiang Liao, Guohui Liu, Chen Lu, Qingquan Luo, Jing Sun, Yanhua Wu, Zhen Xie, Qin Zhang, Lang Zhou

Affiliation: South China University of Technology, Dongguan people's hospital, Sichuan Provincial People's Hospital, People’s Hospital of Xinjiang Uygur Autonomous Region, Second Hospital of Anhui Medical University, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Easy Life Information Technology Co., Ltd, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Medical Physics Program, University of Nevada, Second Hospital of Jilin University, Chongqing Ninth People's Hospital

Abstract Preview: Purpose: Acute kidney injury (AKI) is a global healthcare issue with a rapid onset and severe consequences. Repeated measurement of serum creatinine (SCr) levels, a clinical standard of care, is cruci...

Beam Orientation Optimization in IMRT Using Sparse Mixed Integer Programming and Non-Convex IMRT Fluence Map Optimization

Authors: Yabo Fu, Yang Lei, Yu Lei, Haibo Lin, Ruirui Liu, Tian Liu, Kenneth Rosenzweig, Charles B. Simone, Shouyi Wei, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York Proton Center

Abstract Preview: Purpose: Beam orientation optimization (BOO) in intensity-modulated radiation therapy (IMRT) is traditionally a complex, non-convex problem tackled with heuristic methods. This study benchmarks global...

Best- and Worst-Case Scenario: Uncertainty Bounds Informed By Daily Scanning in Weekly CBCT-Based Accumulated Dose for Head and Neck Cancer

Authors: Peter Balter, Kristy K. Brock, Clifton David Fuller, Tze Yee Lim, James Long, Brigid A. McDonald, Androniki Mitrou, Andrew J. Schaefer, Stina Svensson

Affiliation: The University of Texas MD Anderson Cancer Center, RaySearch Laboratories, Rice University, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences

Abstract Preview: Purpose: CBCT-based accumulated dose can provide up-to-date dose information on responding anatomy. To optimize resources, it is necessary to determine how many scans provide adequate information for ...

Beyond Correlation: An Ultra-Large Physics-Driven Vascularized Tumor Model to Bridge Feature Formation with Underlying Biology

Authors: Jiayi Du, Lihua Jin, Ke Sheng, Yu Zhou

Affiliation: Harvard University, University of California, San Francisco, UCLA, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Radiomics enables powerful insights into tumor biology through non-invasive imaging, excelling in diagnostic and prognostic predictions. However, due to a lack of mechanistic connections, que...

Biomechanically Guided Deep Learning for Deformable Multimodality Liver Registration Framework

Authors: Yunfei Dong, Dongyang Guo, Zhenyu Yang, Fang-Fang Yin, Zeyu Zhang

Affiliation: Duke University, Duke Kunshan University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
To develop a Biomechanically Guided Deep Learning Registration Network (BG-DRNet) that improves both accuracy and physiological plausibility in liver image registration. While cone-beam CT...

Brachyplancheck: An Independent Monte Carlo Dose Calculation Tool for Brachytherapy Using Egs_Brachy

Authors: Amy Tien Yee Chang, Chi Wai Cheung, Tin Lok Chiu, Chen-Yu Huang, Chi Wa Kong, Pei-Xiong Li, Pak Hang Nam, Bin Yang, Siu Ki Yu

Affiliation: Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Medical Physics Department, Hong Kong Sanatorium and Hospital

Abstract Preview: Purpose: This study introduces BrachyPlanCheck, an independent Monte Carlo (MC)-based dose calculation tool for 192Ir brachytherapy retrospective study or algorithm commissioning.
Methods: BrachyPl...

CNN-Based Visualization for Detecting Failure Patterns of Lung SBRT through CT-Biological Effective Dose Interaction

Authors: Ashok Bhandari, Kurtis Johnson, Yu Lei, Tianzhe Li, Kyuhak Oh, Shuo Wang, Chi Zhang, Su-Min Zhou

Affiliation: University of Nebraska Medical Center

Abstract Preview: Purpose: The purpose of this study was to leverage neural network visualization tools to detect high-attention areas indicative of treatment failure in lung SBRT by examining correlation matrices betw...

Calibration of Dynamic Collimation System Trimmers to Proton Beam Axis Using Gantry-Angle-Specific Corrections: A Look-up Table Solution

Authors: Wesley S. Culberson, Albert Du, Ryan T. Flynn, Ryan Gardner, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Blake R. Smith, Nhan Vu, Karsten K. Wake

Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Iowa, Iowa Health Care

Abstract Preview: Purpose: In proton therapy, the substantial size of the gantry introduces sag, causing the proton isocenter to drift as a function of gantry angle. While the scanning magnets correct the beam’s isocen...

Can AI Agent be a Good Judge for Online Adaptive Radiotherapy Plan Evaluation?

Authors: Steve B. Jiang, Mu-Han Lin, Dan Nguyen, Beiqian Qi, Daniel Yang, Ying Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Online adaptive radiotherapy (oART) is a resource-intensive workflow requiring significant time and effort required from clinicians, particularly for the online evaluation of plan quality....

Can We Use Smaller Margin for the Planned Target Volume with Adaptive Radiotherapy?

Authors: Mahmoud H Abdelgawad, Shahabeddin mostafanazhad Aslmarand, Lili Chen, Xiaoming Chen, Ahmed A. Eldib, Teh Lin, Chang Ming Charlie Ma, Robert A. Price

Affiliation: Physics department, Faculty of science, Al-Azhar University, Fox Chase Cancer Center

Abstract Preview: Purpose: Many modern radiotherapy clinics are moving to online adaptive radiotherapy. A recent upgrade of the CBCT-based adaptive radiotherapy system introduced ultra-high-speed image acquisition. Thi...

Centralizing Resources with a Microsoft-Based Wiki Platform: Enhancing Collaboration and Efficiency in Radiation Oncology

Authors: Simon Brundage, Jiajin Fan, Ulrich Langner, Qiongge Li, Jian Liu, Wei Nie, Edwin Quashie, Xiaofeng Zhu

Affiliation: Brown University Health, Hofstra University Medical Physics Program, Inova Hospital, Inova Schar Cancer Institute, Indiana University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose:
Managing departmental policies, clinical protocols, QA procedures, workflows, and troubleshooting documentation is critical in radiation oncology. A Microsoft-based wiki platform was devel...

Characterization of Linear Energy Transfer Spectra in Mini Beam Spatially Fractionated Proton Therapy

Authors: Serdar Charyyev, Kaan Dere, Edgar Gelover, Mohammad Khurram Khan, Liyong Lin, Mark McDonald, Cristina Oancea, Alexander Stanforth, Sibo Tian, Suk Whan (Paul) Yoon, Mingyao Zhu

Affiliation: Department of Radiation Oncology, Stanford University, Stanford University, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Advacam

Abstract Preview: Purpose: The conventional implementation of proton spatially fractionated radiotherapy (SFRT) utilizes physical collimators with apertures to generate minibeams, creating alternating regions of high-d...

Characterizing a VMAT Optimization Algorithm with Integrated Static-Angle Modulated Ports for Esophageal Cancer Treatment

Authors: Lei Dong, Yin Gao, Taoran Li, Michael Salerno, Boon-Keng Kevin Teo, Melissa Vila

Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania

Abstract Preview: Purpose: A novel solution, RapidArc Dynamic-RAD (Varian Medical Systems, Palo Alto, USA) has been implemented to integrate VMAT with modulation of IMRT-like static-angle ports, including use of a dyna...

Chat with Oncology Information System Via Large Language Model

Authors: Michael Dohopolski, Xuejun Gu, Hao Jiang, Steve B. Jiang, Christopher Kabat, Jingying Lin, Weiguo Lu, Michael Tang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Neuralrad LLC, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: To streamline access to clinical data stored in Oncology Information Systems such as MOSAIQ or ARIA, we developed an AI-powered chatbot capable of querying, summarizing, and interactively ans...

Clinical Application of Biology-Guided Radiotherapy (BgRT) to Patient Having a Cardiac Implantable Electronic Device (CIED)

Authors: Girish Bal, Thomas I. Banks, Bin Cai, Yesenia Gonzalez, Zohaib Iqbal, Paul M. Medin, Rameshwar Prasad, Chenyang Shen, Robert Timmerman, Yuanyuan Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: Each year more than one million pacemakers and 200k cardioverter-defibrillators are implanted in patients worldwide. The presence of a CIED introduces challenges to the delivery of radiation ...

Clinical Implementation of Volumetric Modulated Arc Therapy (VMAT) for Total Body Irradiation (TBI) with Off-the-Shelf Tools

Authors: Kai-Cheng Chuang, Oana I. Craciunescu, Christopher Kelsey, Joseph Kowalski, Nicole Larrier, Xinyi Li, Sheridan G. Meltsner, Anna E. Rodrigues, Yang Sheng, Qiuwen Wu

Affiliation: Duke University, Duke University Medical Center

Abstract Preview: Purpose: To clinically implement a Volumetric Modulated Arc Therapy (VMAT) procedure for Total Body Irradiation (TBI) with off-the-shelf tools.
Methods: Patient is treated on linac couch with a hyb...

Clinically Ready Simulation Package for Monitoring Gamma Hotspot Emission, and Detection in Patient Anatomy

Authors: Ananta Raj Chalise, Matthias K Gobbert, Zhuoran Jiang, Sina Mossahebi, Stephen W. Peterson, Jerimy C. Polf, Lei Ren, Ehsan Shakeri, Vijay Raj Sharma, Jie Zhang

Affiliation: University of Maryland School of Medicine, University of Maryland Baltimore County, University of Maryland, Baltimore County, Stanford University, University of Maryland, School of Medine, Department of Physics, University of Cape Town, M3D, Inc

Abstract Preview: Purpose: Prompt gamma (PG) imaging is a promising modality for proton dose verification. Currently, there is a lack of effective tool to investigate the PG emission during proton therapy and optimize ...

Combining Patch-Based CNN Models with Hierarchical Shapley Explanations for Breast Cancer Diagnosis

Authors: Xuelian Chen, John Ginn, Zhuhong Li, Kaizhong Shi, Chunhao Wang, Jianliang Wang, Chuan Wu, Zhenyu Yang, Fang-Fang Yin, Jingtong Zhao

Affiliation: The First People's Hospital of Kunshan, Duke University, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, Department of Radiation Oncology, Duke Kunshan University

Abstract Preview: Purpose: Developing deep learning-based models for accurate automated breast cancer diagnosis from mammography presents significant challenges due to the small size and subtle nature of breast lesions...

Commissioning Silicone Tissue-Compensating Bolus for Electron Beam Therapy

Authors: Carla D. Bradford, Linda Ding, Yansong Geng, Alan Hartford, I-Lin Kuo, Salvatore LaRosa, Joshua N Wancura

Affiliation: University of Massachusetts Chan Medical School

Abstract Preview: Purpose: When treating nasal skin cancers, electron beam radiotherapy dose distributions can be improved by using custom bolus to compensate for uneven surfaces. Here we describe our experience commis...

Commissioning and Validation of Monaco Proton Treatment Planning System on a Compact Proton Therapy System

Authors: Shupeng Chen, Xiaoda Cong, Raymond Dalfsen, Rohan Deraniyagala, Xuanfeng Ding, James E. Dolan, Xiaoqiang Li, Jian Liang, Peilin Liu, An Qin, Martin Soukup, Craig Stevens, Xiangkun Xu, Weili Zheng

Affiliation: Corewell Health William Beaumont University Hospital, Corewellhealth William Beaumont University Hospital, William Beaumont University Hospital, Elekta, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Corewellhealth William Beaumont Hospital, Department of Radiation Oncology, Corewell Health William Beaumont University Hospital

Abstract Preview: Purpose: To facilitate clinical use of the proton feature of Monaco treatment planning system(TPS), we commissioned and validated it on a compact proton therapy system.
Methods: Pencil Beam Scannin...

Comparative Evaluation of Spekpy for Kilovoltage Beam Quality Characterization

Authors: Chang Heon Choi, Yoonsuk Huh, Jin Jegal, Seonghee Kang, Jung-in Kim, Inbum Lee, Hyojun Park

Affiliation: Department of Radiation Oncology, Seoul National University Hospital

Abstract Preview: Purpose: This study evaluates SpekPy, a Python-based tool for modeling kilovoltage (kV) x-ray spectra, by comparing its calculated energy spectra, half-value layer (HVL), and air kerma with experiment...

Comparative Study between Sparse Primary Sampling Grid Scatter Correction and Low-Count Monte Carlo-Based Scatter Reduction with 3-D Richardson-Lucy Denoising

Authors: Alan Rui Li, Qihui Lyu, Dan Ruan, Ke Sheng

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose:
The Sparse Primary Sampling (SPS) grid was shown in a previous computational study to improve image quality by correcting scatter-induced effects and artifacts in Cone-beam Computed Tomogr...

Comparing Planned Vs. Delivered Bladder Dose-Toxicity Associations in Prostate Cancer Radiotherapy: Insights from the Mirage Trial

Authors: Minsong Cao, Amar Kishan, Yi Lao, An Liu, Beth Neilsen, X. Sharon Qi, Kun Qing, Ke Sheng, Michael Steinberg, Luca F Valle, Terence Williams

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, Department of Radiation Oncology, City of Hope Medical Center, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: To investigate the clinical relevance of planned versus delivered doses in toxicity associations utilizing localized assessment of genitourinary (GU) toxicity in bladder subregions among pros...

Comparing the Rsp Accuracy of a Fast Switching Dual-Energy CT to Single-Energy CT Using Proton CT in Animal Tissue.

Authors: Paul Deak, Yang Li, Mark Pankuch, Yanling Qu, Maggie Stauffer, Hazel Wang

Affiliation: Northwestern Medicine Proton Center, GE, Northwestern Medicine

Abstract Preview: Purpose: The objective is to evaluate Relative Stopping Power(RSP) accuracy of ultra-fast switching KV Dual-Energy CT(DECT) in animal tissue and compare it to the RSP converted from Single Energy CT(S...

Comparison of Clinical Virtual Unenhanced and True Unenhanced Images on a Prototype Deep Silicon Photon-Counting Detector CT

Authors: Meghan Lubner, Krista McClure, Aria M. Salyapongse, Timothy P. Szczykutowicz, Giuseppe Toia, Ming Yan, Zhye Yin, Meghan Yue

Affiliation: GE HealthCare, Departments of Radiology and Medical Physics, University Wisconsin-Madison, GE Healthcare, University of Wisconsin-Madison, UW-Madison, University of Wisconsin Madison, Department of Radiology

Abstract Preview: Purpose: To evaluate virtual unenhanced (VUE) and true unenhanced (TUE) human subject images on a prototype deep silicon photon-counting detector (PCD) CT with prototype algorithms.
Methods: 5 subj...

Comparison of Patient Localization on Visionrt Alignrt and Varian Identify

Authors: Ahmed A. Eldib, Teh Lin, Chang Ming Charlie Ma

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose: Surface imaging has been used clinically more regularly. The accuracy of several commercial products has been studied. AAPM TG302 also has proposed the system quality assurance and commission...

Comprehensive Evaluation of High-Performance Cone-Beam Computed Tomography on C-Arm and Ring-Gantry Linacs for Adaptive Radiation Therapy

Authors: Laura I. Cervino, Karen Episcopia, Hsiang-Chi Kuo, Sangkyu Lee, Seng Boh Gary Lim, Shih-Chi Lin, Grace Tang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: This study evaluated the performance of the HyperSight Cone-Beam Computed Tomography (CBCT) system on a TrueBeam C-arm LINAC (TB) and two Ethos ring-gantry LINACs (ES) for adaptive radiation ...

Computational Prototype Single-Channel Vaginal Cylinder with Integrated Filter to Address Dose Uniformity in High-Dose-Rate Brachytherapy for Endometrial Cancer

Authors: Brett Bocian, Patrick James Jensen, Luis Augusto Perles, Christopher J. Tien

Affiliation: Yale University School of Medicine, University of Miami, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Guidelines for dose prescriptions in endometrial cancer are based upon depth from the cylinder, traditionally 5 mm or 0 mm (i.e., surface). There are no current single-channel vaginal cylinde...

Conformal Flash for Large Treatment Fields

Authors: Julien Forthomme, Carolina Llina Fuentes, Valentin Hamaide, Lucian Hotoiu, Rudi Labarbe, Rasmus Nilsson, Arnaud Pin, Francois Vander Stappen, Erik Traneus

Affiliation: RaySearch Laboratories AB, Ion Beam Applications SA

Abstract Preview: Purpose: Conformal FLASH achieves ultra-high-dose-rate (UHDR) proton therapy (>40 Gy/sec) by scanning a mono-energetic pencil beam through accessories (range shifter, Conformal Energy Modulator, apert...

Considerations for Patients with Non-Cied Electronic Devices Undergoing Radiotherapy

Authors: Russell E. Kincaid, Weidong Li, Tarun Kanti Podder, Peter K. Taylor, Vincent Wu

Affiliation: SUNY Upstate Medical University

Abstract Preview: Purpose: An increasing number of cancer patients are presented at radiotherapy clinics with implanted electronic devices other than cardiac implanted electronic devices (CIEDs). Unlike with CIEDs, the...

Contrast-Dependent Loss of Edge Sharpness in Low-Contrast Targets with Increasing Iterative Reconstruction Strength

Authors: Emi Ai Eastman, Christina Lee, Xinhua Li, Alexander W. Scott, Yifang (Jimmy) Zhou

Affiliation: Cedars-Sinai Medical Center

Abstract Preview: Purpose: Iterative reconstruction (IR) methods are valuable for reducing dose in modern CT; however, IR methods have the effect of reducing spatial resolution and hence the lesion edge sharpness. Furt...

Convergence Speed Advantages of a Machine Learning Assisted Framework in IMRT Fluence Map Optimization – a Comparison Study Using Multiple Convergence Criteria

Authors: Yang Sheng, Qingrong Jackie Wu, Qiuwen Wu, Xin Wu, Dongrong Yang

Affiliation: Duke University Medical Center

Abstract Preview: Purpose: Convergence speed is crucial for an optimizer. Faster convergence leads to better solutions with fewer iterations and less time. Recently, a machine learning (ML)-assisted framework employing...

Correction Factors for Estimating Skin Dose from Overresponse of Two Commercial Optically Stimulated Luminescence Dosimeters

Authors: Min Cheol Han, Chae-Seon Hong, Changhwan Kim, Dong Wook Kim, Hojae Kim, Hojin Kim, Jin Sung Kim, HO Lee, Kwangwoo Park, Ye-In Park, Junyoung Son

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Yongin Severance Hospital, Yonsei University College of Medicine

Abstract Preview: Purpose: Overresponse in surface in-vivo dosimetry using optically stimulated luminescence dosimeter (OSLD) depends on the beam incidence angle. This study aimed to investigate correction factors to d...

Cross-Slice Attention for Unsupervised 3D Pelvic CBCT to CT Translation

Authors: Xu Chen, Jun Lian, Yunkui Pang, Pew-Thian Yap

Affiliation: University of North Carolina at Chapel Hill, Huaqiao University

Abstract Preview: Purpose: Unsupervised CBCT-to-CT translation in the pelvic region is essential for accurate radiotherapy delivery and adaptive image-guided interventions. However, current models for cross-modality tr...

Decreasing the Dependence of CT Number on the Position in the Field-of-View Using Photon Counting Detector CT

Authors: Yanle Hu, Shuai Leng, Cynthia H. McCollough, Maryam Sadeghian, Joe Swicklik

Affiliation: Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose: The dependence of CT number on position in the field-of-view (FOV) imposes challenges in radiotherapy treatment planning. This study aims to decrease this dependence using photon counting det...

Deep Learning Based Filter with Back-Projection Operator for CT Reconstruction

Authors: Justus Adamson, Mu Chen, Ke Lu, Zhenyu Yang, Fang-Fang Yin, Rihui Zhang, Yaogong Zhang, Haipeng Zhao, Haiming Zhu, Yuchun Zhu

Affiliation: Shanghai Dacheng Medical Technology, Duke University, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, The First People's Hospital of Kunshan

Abstract Preview: Purpose: In filtered back-projection (FBP) reconstruction, conventional filters often reduce noise at the expense of high-frequency details, leading to structural details loss. To address this limitat...

Deep Learning-Based Eye Monitoring and Tracking System for Ocular Proton Therapy in a Regular Gantry Room

Authors: David H. Abramson, Christopher Barker, Jasmine H. Francis, Meng Wei Ho, Yen-Po Lee, Haibo Lin, Hang Qi, Andy Shim, Charles B. Simone, Weihong Sun, Xiaoxuan Xu, Siyu Yang, Francis Yu, Anna Zhai

Affiliation: College of Machine Intelligence, Nankai University, New York Proton Center, Department of Biomedical Engineering, Johns Hopkins University, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Proton therapy is an effective modality for treating ocular tumors such as uveal melanoma. We developed a novel camera‐based eye‐tracking system to provide real-time noninvasive eye positioni...

Deep Learning-Based Ventricular Auto-Segmentation for Dosimetric Analysis in Intraventricular Tumor SRS

Authors: John Byun, Juan J Cardona, Steven D Chang, Cynthia Fu-Yu Chuang, Xuejun Gu, Yusuke Hori, Hao Jiang, Fred Lam, Lianli Liu, Weiguo Lu, David Park, Erqi Pollom, Elham Rahimy, Deyaaldeen Abu Reesh, Scott Soltys, Gregory Szalkowski, Lei Wang

Affiliation: Department of Radiation Oncology, Stanford University, Department of Neurosurgery, Stanford School of Medicine, Department of Neurosurgery, Stanford University, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Intraventricular tumors pose significant challenges in neurosurgery due to their complex location. Therefore, brain SRS could be a better treatment option. At our institution, some patient...

Deeptuning: A Deep Learning Dose Prediction Framework for Interactive Plan Tuning

Authors: Mingli Chen, Huan Amanda Liu, Weiguo Lu, Lin Ma

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Mayo Clinic

Abstract Preview: Purpose: To reduce the back-and-forth in planning process between physicians and dosimetrists resulting from trade-off exploration, we proposed a novel deep learning framework called DeepTuning.
Me...

Dependency of CT Number on Position in the Field-of-View for Single- and Multi-Energy Images Acquired with Energy-Integrating-Detector and Photon-Counting-Detector CT Scanners

Authors: Yanle Hu, Shuai Leng, Cynthia H. McCollough, Maryam Sadeghian, Joe Swicklik

Affiliation: Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose: To assess the dependency of CT numbers on position in the field-of-view (FOV) using single-energy (SE) and dual-energy (DE) images and energy-integrating detector (EID) and photon-counting de...

Design and Testing of an External Control System for Beam Control and Pre-Delivery Optimization for Conventional- and Ultra-High-Dose-per-Pulse Flash Irradiations

Authors: Alexander Baikalov, Luke Connell, Nicholas Coupey, Nolan M. Esplen, Rebecca Lim, Chinh Nguyen, Emil Schueler

Affiliation: Northwell, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: FLASH radiotherapy delivered using electron linear accelerators (LINAC) requires precise control and minimal variation of dose rate and We developed a robust external beam control system (EBC...

Designing Impactful Radiotherapy Training for Skill Development and Long-Term Growth

Authors: Stephanie Bennett, Sean L. Berry, Caroline M. Colbert, Dustin J. Jacqmin, James A. Kavanaugh, Minsun Kim, Maura L. Kirk, Emily Kruse, Benjamin Li, Mu-Han Lin, Lindsey A. Olsen, Jose Carlos Pichardo, Justin R. Roper, Leah K. Schubert, Chunhao Wang, Sua Yoo

Affiliation: University of Wisconsin, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Abington - Jefferson Health, Mayo Clinic, University of Washington, University of Colorado Health, University of Colorado Denver, Department of Radiation Oncology, University of Washington and Fred Hutch Cancer Center, Duke University, Pichardo Physics LLC, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: As clinics in lower- and middle-income countries (LMICs) transition to advanced radiotherapy techniques like IMRT and VMAT, gaps in training can result in suboptimal planning. To help support...

Developing Patient-Specific Functional Atlases with Inverse Distance Weighting of MR Images

Authors: Chibawanye I. Ene, Sherise D. Ferguson, Ping Hou, Vinodh A. Kumar, Ho-Ling Anthony Liu, Kyle R. Noll, Sujit S. Prabhu, Jian Ming Teo, Max Wintermark

Affiliation: Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose:
Functional brain atlases are used to guide clinical functional MRI (fMRI) analyses. Imprecise assertions may introduce the ecological fallacy as atlases are reflective of the constituent c...

Development of Treatment Planning System for Carbon Ion Radiotherapy in Yonsei Cancer Center

Authors: Min Cheol Han, Chae-Seon Hong, Changhwan Kim, Dong Wook Kim, Hojin Kim, Jin Sung Kim, HO Lee, Sac Lee, Yongdo Yun

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine

Abstract Preview: Purpose: Carbon ion radiotherapy (CIRT) offers the advantage of a greater relative biological effectiveness (RBE) weighted dose, which must be integrated into the treatment planning system (TPS). This...

Development of a Brain-like Digital Reference Object of Resting-State Functional MRI

Authors: Henry Szu-Meng Chen, Mu-Lan Jen, Vinodh A. Kumar, Ho-Ling Anthony Liu, Jian Ming Teo

Affiliation: School of Medicine, University of Colorado Denver, Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Resting-state (rs-) fMRI detects functional networks by measuring synchronization of low-frequency oscillations in blood-oxygenation-level-dependent (BOLD) signals between brain regions. Stan...

Development of a GPU-Based Dose Calculation Engine for MRI-Guided Proton Therapy

Authors: Yaowen Cao, Haonian Gong, Yue Gu, Meiqi Liu, Hsiao-Ming Lu, Yuxiang Wang, Yidong Yang, Xiaogang Yuan

Affiliation: Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China

Abstract Preview: Purpose: Magnetic resonance imaging (MRI)-guided proton therapy is an innovative technology that combines superior soft tissue imaging capabilities of MRI with the high dose conformity of proton thera...

Development of an Inverse Treatment Planning System for Precision Small Animal Radiotherapy

Authors: Zihao Liu, Qiwei Wu, Yanfei Xiong, Yidong Yang, Ning Zhao

Affiliation: Department of Engineering and Applied Physics, School of Physical Sciences, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China, University of Science and Technology of China

Abstract Preview: Purpose: To develop an inverse planning framework that optimizes beam angles and intensities for small animal radiotherapy and to validate its accuracy and effectiveness.
Methods: The inverse plann...

Development of the First Benchtop X-Ray Flash System

Authors: Ruirui Dong, Gernot Echner, Peter Haering, Clarence King, Carlos Murillo, Gavin Poludniowski, Nicholas Sammut, Joao Seco, Steffen Seeber, Maria Francesca Spadea, Elpida Theodoridou

Affiliation: KIT, Department of Physics and Astronomy, Heidelberg University, Karolinska Institutet, DKFZ, University of Malta

Abstract Preview: Purpose:
The goal is to develop the first benchtop X-ray FLASH system based on a conventional small animal irradiator. The small animal irradiator will be modeled using a Monte Carlo toolkit for bo...

Developments of a Low-Cost Multi-Target Winston-Lutz Phantom and Software for SRS Linac Machines

Authors: Nellie Brovold, Wenbo Gu, Huan Amanda Liu, Lin Ma

Affiliation: University of Pennsylvania, Mayo Clinic

Abstract Preview: Purpose: To develop a low-cost comprehensive QA phantom and software for single-iso multi-target SRS Linac machines. This phantom can perform 1) Winston-Lutz QA test for on-axis and off-axis targets, ...

Differential Gastrointestinal Responses to Synchrotron-Produced Proton and Electron Irradiation Under Flash and Conventional Conditions

Authors: Luke Connell, Nolan M. Esplen, Elise Konradsson, Albert C. Koong, Ziyi Li, Steven Hsesheng Lin, Kevin Liu, Billy W Loo, Devarati Mitra, Radhe Mohan, Emil Schueler, Takeshi Takaoka, Uwe Titt, Xiaochun Wang, Ming Yang

Affiliation: The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: This study aimed to assess radiation-induced gastrointestinal (GI) toxicity in mice subjected to abdominal irradiation using protons at ultra-high-dose-rate (UHDR) and conventional dose-rates...

Diffusion Model-Based Motion Correction in Portable Computed Tomography for Brain: Human Observer Study

Authors: Rajiv Gupta, Rehab Naeem Khalid, Min Lang, Michael H Lev, Quirin Strotzer, Matthew Tivnan, Maryam Vejdani-Jahromi, Dufan Wu, Siyeop Yoon, Chen Zhennong

Affiliation: Massachusetts General Hospital

Abstract Preview: Purpose: Patient motion is a major source of artifacts in portable brain CT due to the slow scanning speed. A diffusion model was developed to reduce these motion artifacts. This work aims to assess t...

Direct Table Rotational Isocenter Determination Using Radiation Isocenter

Authors: Christopher Ackerman, Chang Chang, Yansong Liu, Stephen Kenneth Northway, Bailey Vallejo

Affiliation: University of California San Diego / California Protons, California Protons Cancer Therapy Center, California Proton Cancer Therapy Center

Abstract Preview: Purpose: To determine mechanical isocenter of a 6-degree-of-freedom (6DOF) couch using radiation isocenter. Coincidence between the isocenters is quantified using MyQA Phoenix amorphous silicon detect...

Dosimetric Evaluation of Comprehensive Motion Management in 1.5T MR-Linac for Real-Time Gated Radiotherapy

Authors: Kin Yin Cheung, Chen-Yu Huang, Chi Wah Kong, Ka Ki Lau, Pei-Xiong Li, Pak Hang Nam, Mei Yan Tse, Jierong Wang, Bin Yang, Siu Ki Yu, Jing Yuan, Chi To Yung, Shang Peng Felix Yung

Affiliation: Medical Physics Department, Hong Kong Sanatorium and Hospital, Research Department, Hong Kong Sanatorium and Hospital

Abstract Preview: Purpose: Intrafraction motion management remains a major challenge in magnetic resonance-guided radiotherapy (MRgRT). The recent clinical release of an active motion management system aims to enhance ...

Dosimetric Evaluation of the Aldo Function for Multiple Brain Metastases in Automated Stereotactic Radiosurgery Treatment Planning

Authors: Hsiao-Mei Fu, Shih-Ming Hsu, Chia-Ting Lee, Shih-Hua Liu, Tsung-Yu Yen

Affiliation: National Yang Ming Chiao Tung University, Mackay Memorial Hospital

Abstract Preview: Purpose: The Automatic Lower Dose Objective (ALDO) is a unique function designed to achieve 98% relative coverage across all targets in automated SRS treatment planning (HyperArc planning). This study...

Dosimetric Impact of Adaptive Radiotherapy with Ethos for Prostate Cancer: Localized Analysis of Bladder and Rectum across Planned, Non-Adaptive Accumulated, and Adapted Treatments

Authors: Huisi Ai, Scott Glaser, Yi Lao, Percy Lee, Sara N. Lim, An Liu, Bo Liu, Borna Maraghechi, Kun Qing, Chengyu Shi, William T. Watkins, Terence Williams, Qiuyun Xu, Jiahua Zhu

Affiliation: WashU Medicine, Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, City of Hope Orange County, Department of Radiation Oncology, City of Hope National Medical Center, Department of Radiation Oncology, City of Hope Orange County, Department of Radiation Oncology, City of Hope Medical Center

Abstract Preview: Purpose: To employ a novel surface dose mapping approach for localized assessment of the dosimetric impact of Ethos adaptive radiotherapy (ART) for prostate cancer (PC).
Methods: This study include...

Dosimetric Validation and Algorithmic Limitations of Pencil Beam Scanning Proton Therapy for Thin Chest-Wall Treatments

Authors: J Isabelle Choi, Meng Wei Ho, Isabel Lin, Hang Qi, Qi Zeng, Ajay Zheng

Affiliation: New York Proton Center, Scarsdale High School

Abstract Preview: Purpose: Proton therapy is a promising treatment modality for breast cancer due to its unique dosimetric advantage. Accurate dose calculation is critical to ensure effective treatment outcomes. The fo...

Dual-Domain Reconstruction Network for Nonstop Gated CBCT Imaging: Application in Respiratory Gating Ablative Radiotherapy for Pancreatic Cancer

Authors: Sean L. Berry, Weixing Cai, Laura I. Cervino, Yabo Fu, Daphna Gelblum, Wendy B. Harris, Xiuxiu He, Licheng Kuo, Tianfang Li, Xiang Li, Jean M. Moran, Boris Mueller, Huiqiao Xie, Mitchell Yu, Hao Zhang

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Gating ablative radiotherapy for pancreatic cancer accounts for tumor movement due to respiration and typically requires 5, 15, or 25 fractions. Pretreatment imaging verification is essential...

EBT4 Film Dosimetry and the Significance of the ¼ Fwhm Rule for Gamma Knife Output Factors

Authors: Jingying Lin, Stevan Pecic, Strahinja Stojadinovic

Affiliation: University of Belgrade, The University of Texas Southwestern Medical Center

Abstract Preview: Purpose: This study aims to determine the magnitude of polarization-induced dosimetric error for EBT4 films at different scanning orientations, and to provide guidance on selecting appropriate regions...

Early GU Toxicity Prediction in Prostate SBRT Using Delivered Dosimetry Via Long Short-Term Memory Model

Authors: Amar Kishan, Jun Lian, Yunkui Pang, Jonathan Pham, X. Sharon Qi, Michael Steinberg, Luca F Valle, Pew-Thian Yap

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of North Carolina at Chapel Hill

Abstract Preview: Purpose: Stereotactic body radiotherapy (SBRT) is a highly effective treatment for prostate cancer, yet predicting genitourinary (GU) toxicity has primarily relied on planned dosimetry. This study inv...

Effects of Skin Gap and Applicator Tilt on Dose Coverage for Skin Lesions Treatment with Leipzig Applicator

Authors: Awens Alphonse, Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Nishan Shrestha

Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: This study aims to quantify the dose discrepancy associated with improper placement of the Leipzig applicator on the patient's skin.
Methods: Monte Carlo simulations were performed using t...

Efficient Denoising of Low-Statistic Influence Matrices Using a Diffusion Transformer-Based Framework for Adaptive Proton Therapy

Authors: Yuzhen Ding, Hongying Feng, Jason Michael Holmes, Baoxin Li, Wei Liu, Daniel Ma, Lisa McGee, Samir H. Patel, Jean Claude M. Rwigema, Sujay A. Vora

Affiliation: Arizona State University, Department of Radiation Oncology, Mayo Clinic, Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose:
Intensity-modulated proton therapy (IMPT) is a preferred treatment modality for head and neck (H&N) cancer patients, offering precise tumor targeting while sparing surrounding organs at ri...

Efficient FAST-Forward Planning Strategy for X-Ray Based Online Adaptive Radiotherapy

Authors: Prasanna Alluri, Mona Arbab, Xingzhe Li, Chang-Shiun Lin, Mu-han Lin, David D.M. Parsons, Asal Rahimi, Justin D. Visak, Narine Wandrey

Affiliation: UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX

Abstract Preview: Purpose: Intelligence-Optimization-Engine (IOE) v1.0 relied heavily on planner expertise and patient-specific IMRT beam arrangements, requiring frequent revisions. While VMAT workflows offered potenti...

Efficient Monte Carlo Proton Dose Calculation Using Denoising Diffusion Probabilistic Models

Authors: Chieh-Ya Chiu, Shen-Hao Li, Hsin-Hon Lin, Shu-Wei Wu

Affiliation: Department of Medical Imaging and Radiological Sciences, Chang Gung University, Proton and Radiation Therapy Center, Chang Gung Memorial Hospital Linkou

Abstract Preview: Purpose: Monte Carlo simulation enables precise calculation of dose distribution in proton therapy through tracing the radiation particles with patient tissues. However, achieving clinical-level preci...

Efficient Monte Carlo Simulation of Radiation-Induced Double Strand Break Production and Repair Kinetics

Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal, Chris C. Wang

Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology

Abstract Preview: Purpose: Radiobiological simulation via TOPAS-nBio requires significant computational resources and time to provide meaningful results. This study aims to decrease simulation time and computational re...

Efficient Robustness Optimization in Intensity Modulated Proton Therapy for Head and Neck Cancer Via Visual State Space Attention Generative Adversarial Networks (VSSA-GAN)

Authors: Nan Li, Yaoying Liu, Shouping Xu, Gaolong Zhang

Affiliation: Department of Radiation Oncology, School of Physics, Beihang University, School of physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose: In intensity-modulated proton therapy (IMPT) for head and neck cancer, CBCT registration ensures accurate setup, minimizing dose errors. Unlike IMRT, IMPT plans directly define tumor volumes ...

Enhancing Dosimetric Conformity in Single-Energy Bragg Peak Flash Therapy Using Aperture-Based Techniqu

Authors: Chin-Cheng Chen, Chingyun Cheng, Longfei Diao, Benjamin Durkee, Minglei Kang, Haibo Lin, LeLe Liu, Yangguang Ma, Xuanqin Mou, YunTong Pei, Charles B. Simone, YuFei Wang, Xueqing Yan, Xingyi Zhao, Wang Zhengda

Affiliation: Peking University, St. Jude Children's Research Hospital, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, School of Software Engineering, Xi’an Jiaotong University, School of information and communications engineering, Faculty of electronic and information engineering, Xi’an Jiaotong University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: This study evaluates the effectiveness of apertures in improving lateral dose falloff in proton pencil beam scanning (PBS) single-energy Bragg peak (SEBP) FLASH radiotherapy (RT). The approac...

Enhancing Robustness in Proton Therapy through Online Adaptive Workflow: An in-Silico Study

Authors: Robbie Beckert, Weiren Liu, Thomas R. Mazur, Allen Mo, Stephanie Perkins, Hailei Zhang, Tianyu Zhao

Affiliation: Washington University in St. Louis School of Medicine, University of South Florida, WashU Medicine

Abstract Preview: Purpose: Online adaptation may mitigate uncertainties in proton therapy arising from interfractional anatomical changes. While robust optimization accounts for setup and range uncertainties during pla...

Enhancing the CT Contrast Via Attention-Gated Contrast Enhancement Gan (AGCE-GAN)

Authors: Nan Li, Yaoying Liu, Shouping Xu, Xinlei Xu, Gaolong Zhang

Affiliation: School of Physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, School of physics, Beihang University, Beihang University, Department of Radiation Oncology

Abstract Preview: Purpose:
CT simulation is essential for radiation therapy preparation but has limitations in distinguishing lesions. Contrast-enhanced CT (CECT) improves lesion detection and characterization, but ...

Evaluate a Deep-Learning Auto-Segmentation Software for Liver SIRT

Authors: Wookjin Choi, Jun Li

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: Resin Yttrium-90 (Y-90) selective internal radiation therapy (SIRT) is a radioembolization procedure which uses Y-90 microspheres to treat metastatic liver cancer. In the procedure, liver vol...

Evaluating Deep Learning Models for Accurate Segmentation of GTV and Oars in MR-Guided Adaptive Radiotherapy for Pancreatic Cancer

Authors: Christopher G. Ainsley, Pradeep Bhetwal, Yingxuan Chen, Wookjin Choi, Vimal K. Desai, Karen E. Mooney, Adam Mueller, Hamidreza Nourzadeh, Yevgeniy Vinogradskiy, Maria Werner-Wasik

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: MR-guided adaptive radiotherapy (MRgART) has demonstrated improved outcomes for patients with pancreatic cancer. However, the time-consuming re-segmentation of targets and organs-at-risk (OAR...

Evaluating Dose Variability in Bladder Contouring for MR-Guided Prostate Cancer Radiotherapy

Authors: Emily Helen Hayes, Chihray Liu

Affiliation: University of Florida

Abstract Preview: Purpose: To evaluate dosimetric discrepancies in bladder dose calculations among rigid, deformed, and manual contouring methods in prostate cancer patients and assess dose variations resulting from bl...

Evaluation of Concomitant Imaging Dose in 4D-CBCT Guided Thoracic Radiotherapy

Authors: Yuchao Hu, Yajun Jia, Zhangmin Li, Yong Sang, Jianan Wu, Man Zhao

Affiliation: Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Radiation Oncology, Guangzhou Concord Cancer Hospital, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose: To evaluate the imaging dose of 4D-CBCT in patients treated with thoracic radiotherapy.
Methods: A model of the Elekta XVI imaging system was created in TOPAS software. Percentage depth do...

Evaluation of Daily Respiratory Pattern from a Single Free-Breathing Cone Beam CT Scan

Authors: Weixing Cai, Laura I. Cervino, Yabo Fu, Xiuxiu He, Tianfang Li, Xiang Li, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose:
This work aims to develop an innovative technique to evaluate patients’ daily respiratory pattern using three-dimensional (3D) deformation vector fields (DVF) derived from a free-breathing...

Evaluation of Fast Monte Carlo Secondary Dose Calculation for Intensity Modulated Proton Therapy in Heterogeneous Materials

Authors: Ergun E. Ahunbay, Abdul Kareem Parchur, Eric S. Paulson, Ilaria Rinaldi, Angelo Schiavi, Li Zhao

Affiliation: Sapienza University of Rome, Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Secondary dose calculations (SDC) facilitate patient-specific quality assurance for online adaptive intensity-modulated proton therapy (IMPT). However, there is currently a lack of commercial...

Evaluation of Hybrid Dynamic Conformal Arc Planning for SRS and SBRT Treatment

Authors: Pat Esposito, Ashley Klein, Carmine Verna, Ling Zhuang

Affiliation: Northwestern Medicine

Abstract Preview: Purpose: To evaluate dosimetric parameters and treatment delivery efficiency between volumetric modulated arc therapy (VMAT) and hybrid dynamic conformal arc (HDCA) on SRS and SBRT planning through st...

Evaluation of Hypersight CBCT Scanning Techniques for Motion Management in Online Adaptive Radiotherapy: A Comparative Study of Slow, Fast, and Averaged Scans

Authors: Fan Liu, Adam C. Riegel, Yi-Fang Wang

Affiliation: Columbia University Irving Medical Center

Abstract Preview: Purpose: HyperSight, Varian Medical Systems' latest CBCT technology, integrates rapid 6-second data acquisition with advanced iterative reconstruction, enabling precise real-time contouring and dose c...

Evaluation of Thoracic Direct Dose Calculation Using Truebeam Linac with Hypersight Imaging CBCT Solution

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Alex T. Price, Sagar Regmi, Atefeh Rezaei, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: To investigate the feasibility and accuracy of using a Hounsfield Unit(HU) calibrated cone-beam computed tomography(CBCT) for direct dose calculation in thoracic treatment settings. In combin...

Evaluation of Time Delays in a Surface-Guided Radiotherapy-Based Gating System Using Exactrac Dynamic and Truebeam Linear Accelerator

Authors: Hiroki Katayama, Hiroki Kawasaki, Motonori Kitaoka, Yosuke Takahashi, Takashi Tanii, Masato Tsuzuki

Affiliation: Kagawa University Hospital

Abstract Preview: Purpose:
Surface-guided radiotherapy (SGRT) with ExacTrac Dynamic (ETD) allows motion tracking and beam gating during treatment delivery. Accurate evaluation of beam-on and beam-off delays is essen...

Evaluation of Treatment Planning Feasibility and Dosimetric Quality of the Reflexionā„¢ X1 System for Complex Spinal Targets

Authors: Thomas I. Banks, Bin Cai, Andrew R. Godley, Yang Kyun Park, Hao Peng, Rameshwar Prasad, Chenyang Shen, Shunyu Yan, Haozhao Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, University of Texas Southwestern Medical Center

Abstract Preview: Purpose:
The RefleXionĀ® X1 (RefleXion Medical, Inc., Hayward, CA) uniquely integrates KVCT and PET as on-board image guidance for radiotherapy. It has been installed and commissioned for clinical u...

Evaluation of the Dosimetric Characteristics of Multi-Layers of Brass Mesh Bolus for Electron Treatment

Authors: Yunzhi Ma, Ling Zhuang

Affiliation: Northwestern Medicine

Abstract Preview: Purpose: Multiple layers of brass mesh bolus (RPD, Inc., Albertville, MN) may be needed to provide better body conformity and sufficient dose build up on patient surface during electron treatment. Thi...

Evaluation of the Reflexion X1 As a Standalone PET/CT Simulator for Treatment Planning and Treatment Adaptation

Authors: Chunhui Han, An Liu, William T. Watkins, Qiuyun Xu

Affiliation: Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: To evaluate the RefleXion X1 imaging system as a standalone positron emission tomography and computed tomography (PET/CT) simulator for radiotherapy treatment planning and adaptive re-plannin...

Feasibility of Producing GRID Therapy Dosimetry Using a Compact Linac Treatment Head with Pencil Beam Scanning

Authors: Yiran Liu, Zhengzheng Liu, Fang-Fang Yin

Affiliation: Duke Kunshan Univeristy, Huazhong University of Science and Technology, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: To investigate the feasibility of producing high dose rate GRID therapy using a compact linear accelerator (LINAC) treatment head with scanning beam and stationary grid collimator.
Methods...

Feasibility of Using 68ga-PSMA for Biology-Guided Radiotherapy (BgRT) Treatment

Authors: Girish Bal, Thomas I. Banks, Bin Cai, Neil Desai, Aurelie Garant, Orhan Oz, Elizeva Phillips, Rameshwar Prasad, Chenyang Shen, Robert Timmerman

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: This study reports findings from the first-in-human imaging-only trial evaluating the feasibility of using the novel PET tracer 68Ga-PSMA-11 (Illuccix) to guide external beam radiotherapy on ...

Feasibility of X-Ray Based Online Adaptive Dynamic Optimization with Integrated Knowledge-Based Planning for Head and Neck Cancer

Authors: Jacob S. Buatti, Mu-Han Lin, Dominic Moon, David D.M. Parsons, David Sher, Justin D. Visak, Hui Ju Wang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX

Abstract Preview: Purpose: Most current adaptive treatment planning systems (TPS) natively utilize static planning goals from the reference plan for online adaptive re-optimization. In complex head-and-neck cancer (HNC...

Film-Based Method for Accurate Radiation Isocenter Determination in Linear Accelerators Using 3D Starshot

Authors: Robert A. Corns, Mohammad Kanber

Affiliation: East Carolina University, East Carolina University Brody School of Medicine

Abstract Preview: Purpose:
Accurate determination of the radiation isocenter is crucial for precise radiotherapy treatments, directly impacting patient safety and treatment quality. This study presents a computation...

Fine-Tuning AI-Based Generative Models for Small-Sample Glioma MRI Generation.

Authors: Xiangli Cui, Chunyan Fu, Man Hu, Wanli Huo, Jingyu Liu, Jianguang Zhang, Yingying Zhang, Shanyang Zhao

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University, Departments of Radiation Oncology, Zibo Wanjie Cancer Hospital, Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province, College of Information Engineering, China Jiliang University, Department of Oncology, Xiangya Hospital, Central South University, College of Information Engineering, China Jiliang University, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences

Abstract Preview: Purpose: To quantify the impact of fine-tuning strategies for pre-trained AI image generation models on glioma MRI image quality and observer performance, and to determine the optimal fine-tuning conf...

Foundation Models with Balanced Data Sampling Enhance Auto-Segmentation for Cardiac Substructures

Authors: Chloe Min Seo Choi, Nikhil Mankuzhy, Aneesh Rangnekar, Andreas Rimner, Maria Thor, Harini Veeraraghavan, Abraham Wu

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Cardiac substructure irradiation predisposes patients for poor outcomes in thoracic radiation therapy. A deep learning model was developed to segment the cardiac substructures invariant to co...

Frameless and Maskless Stereotactic Radiosurgery: Evaluating a Novel Robotic Head Motion Compensation Device

Authors: Michelle Alonso-Basanta, Carl Denis, Wenbo Gu, Xinmin Liu, Ahmad Sakaamini, Rodney D. Wiersma

Affiliation: UCLA, University of Pennsylvania, CDR Systems

Abstract Preview: Purpose: Stereotactic radiosurgery (SRS) is a non-invasive technique used to treat functional abnormalities and small brain tumors. Traditional SRS relies on a rigidly fixed metal head ring, causing d...

Free-Breathing Spirometer-Gated Proton Pencil Beam Scanning Delivery Maintains Tumor Coverage with Improved Organ-at-Risk Sparing: A Motion Phantom Validation

Authors: Uriel Aura, Qing Chen, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Meng Wei Ho, Sheng Huang, Minglei Kang, Stanislav Lazarev, Nancy Y Lee, Yang Lei, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Anna Zhai, Ajay Zheng

Affiliation: DYN'R Medical System, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Tianjin Medical University Cancer Institute&Hospital, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: Managing tumor motion during pencil beam scanning proton therapy remains challenging. This study investigated the feasibility and dosimetric benefits of Free-Breathing Respiratory-Gated Deliv...

Fully Automated Zero-Shot Organ Segmentation in Male Pelvic MR Images for MR-Guided Radiation Therapy

Authors: Jihun Kim, Jin Sung Kim, Jun Won Kim, Yong Tae Kim, Chanwoong Lee, Jihyn Pyo, Young Hun Yoon

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine

Abstract Preview: Purpose: Although segmentation foundation models have recently demonstrated promising zero-shot performance on natural images, its clinical application to magnetic resonance (MR) images still requires...

GPU-Accelerated Beamlet and Full Dose Calculations for Efficient Radiation Therapy Planning

Authors: Girish Bal, Jan Kralj, Ayan Mitra, PhD, Ling Shao, Matjaz Subic, Yevgen Voronenko

Affiliation: RefleXion Medical, Cosylab

Abstract Preview: Purpose: This work enhances the efficiency of radiation therapy treatment planning by optimizing the beamlet dose matrix and full patient dose computations using GPU acceleration. The Collapsed-Cone C...

Generating 3D Brain in Volume (BRAVO) Images Using Attention-Gated Conditional Gan (AGC-GAN)

Authors: Nan Li, Shouping Xu, Gaolong Zhang, Xuerong Zhang

Affiliation: Department of Radiation Oncology, HeBei YiZhou proton center, School of Physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose:
The 3D BRAVO sequence is an advanced magnetic resonance (MR) technique that allows for image reconstruction at any angle. It offers 1 mm gapless scanning and has a high signal-to-noise rat...

Generation of Patient-Specific Phantom for Head & Neck Proton Therapy Based on Xcat

Authors: Cheng-En Hsieh, Shen-Hao Li, Hsin-Hon Lin, Shu-Wei Wu, An-Ci Yang

Affiliation: Department of Medical Imaging and Radiological Sciences, Chang Gung University, Proton and Radiation Therapy Center, Chang Gung Memorial Hospital, Proton and Radiation Therapy Center, Chang Gung Memorial Hospital Linkou

Abstract Preview: Purpose:
The aim of this study is to develop a framework of generating patient-specific phantom tailored for head and neck proton therapy. From these phantoms, digital reference objects based on th...

Getting in Focus: Review of Current Focal Spot Size Testing Methods with Flat Panel Digital Radiography Detectors

Authors: Matthew R. Hoerner, Maryam Naseri, Mena Shenouda

Affiliation: Yale University School of Medicine, Yale University

Abstract Preview: Purpose:
Historically film has been the gold standard receptor for measurements of x-ray tube focal spot size. Flat Panel Digital Radiography Detectors (FPDRDs) have lower spatial resolution compar...

Gradient-Based Radiomics for Outcome Prediction and Decision-Making in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR): A Preliminary Study

Authors: Michael Dohopolski, Jiaqi Liu, Hao Peng, Robert Timmerman, Zabi Wardak, Haozhao Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
This study introduces a gradient-based radiomics framework to enhance outcome prediction in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR) for brain metastases...

Graph Neural Network with Long Short-Term Memory for CT-Based Macrotrabecular-Massive Hepatocellular Carcinoma Diagnosis

Authors: Enhui Chang, Yunfei Dong, Yifei Hao, Chengliang Jin, Shengsheng Lai, Yi Long, Mengni Wu, Yulu Wu, Ruimeng Yang, Zhenyu Yang, Yue Yuan, Lei Zhang, Wanli Zhang, Yaogong Zhang

Affiliation: Duke Kunshan University, Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: Macrotrabecular-Massive Hepatocellular Carcinoma (MTM-HCC) is one type of liver cancer showed minimum image signature for accurate non-invasive diagnosis. This study aims to develop and evalu...

High Resolution Head Motion Correction Based on Pilot Tone Signals – a Calibration-Free Method

Authors: Cheng-Chieh Cheng, Jeffrey P Guenette, Yajun Li, Bruno Madore, Lei Qin

Affiliation: Brigham and Women's Hospital, National Sun Yat-sen University, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Pilot tone (PT), a compact RF sensor, has been integrated into clinical practice for motion detection. Prior studies proposed mapping PT signals to head positions using a calibration step tha...

High-Quality Patchnet (HQ-PatchNet) for Synthetic CT Generation in Head & Neck Imaging

Authors: So Hyun Ahn, Chris Beltran, Byongsu Choi, Jeong Heon Kim, Jin Sung Kim, Bo Lu, Justin Chunjoo Park, Bongyong Song, Jun Tan

Affiliation: Mayo Clinic, Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Ewha Medical Research Institute, Ewha Womans University College of Medicine, UC San Diego, Yonsei University College of Medicine

Abstract Preview: Purpose:
Cone-beam computed tomography (CBCT) is widely used in IGRT for patient positioning but suffers from low resolution and poor soft tissue contrast. Synthetic CT (sCT) generated from CBCT ad...

High-Temporal Dynamic CBCT Imaging Via Gaussian Neural Representation

Authors: Weixing Cai, Laura I. Cervino, Yabo Fu, Licheng Kuo, Tianfang Li, Xiang Li, Jean M. Moran, Huiqiao Xie, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: This study introduces a novel spatiotemporal Gaussian neural representation framework to reconstruct high-temporal dynamic CBCT images from 1-minute acquisition, preserving motion dynamics an...

Hyperbaric Oxygen Therapy Prior to SRS Does Not Enhance Radiosensitivity in the Murine Glioblastoma Model

Authors: Beverly Allen, Jay C. Buckey, David J. Gladstone, P. Jack Hoopes, David I Hunter, Armin Tavakkoli

Affiliation: Thayer School of Engineering, Dartmouth College, Geisel School of Medicine, Dartmouth College, Geisel School of Medicine, Thayer School of Engineering

Abstract Preview: Purpose: Hyperbaric oxygen (HBO) therapy immediately prior to radiation therapy has been proposed as treatment to enhance radiosensitivity of hypoxic tumors. A murine glioblastoma model was utilized t...

Impact of Beamline Mis-Adjustment Following Central Beamline Replacement for Halcyon Linear Accelerator

Authors: Emily Y. Hirata, Xiaoyu Sherry Liu, Evan Porter, Manju Sharma

Affiliation: University of California San Francisco, University of California, San Francisco, University of California

Abstract Preview: Purpose: Introduced in 2018, the Varian Halcyon platform has increased in popularity due to its reduced cost, user-friendly design, and operational efficiency. As this platform ages, major repairs, in...

Impact of Lung Density on Plan Quality and Delivery Parameters in Lung Stereotactic Body Radiation Therapy (SBRT) Plans

Authors: David Chighvinadze, Indra J. Das, Jeremy D. Donaghue, Kevin Stephans, Gregory Videtic, Sugandima Weragoda, Ping Xia

Affiliation: Cleveland Clinic, Cleveland Clinic Sandusky, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Cleveland Clinic Fairview

Abstract Preview: Purpose:: Evaluate the impact of lung density variations on plan quality and delivery parameters in lung SBRT Plans.
Methods: For a hypothetical case with a real patient anatomy, three GTVs with vo...

Impact of Respiratory Motion and MRI Sequences on Tumour Volume Determination in MR-Guided Radiotherapy

Authors: Kin Yin Cheung, Chen-Yu Huang, Chi Wa Kong, Pei-Xiong Li, Pak Hang Nam, Bin Yang, Siu Ki Yu, Chi To Yung

Affiliation: Medical Physics Department, Hong Kong Sanatorium and Hospital

Abstract Preview: Purpose:
The Elekta Unity system facilitates daily adaptive radiotherapy using MRI-based treatment planning. However, MR images are prone to motion artefacts caused by respiratory motion, potential...

Implementation of a Visual Feedback System for Respiratory Gated Intensity Modulated Proton Therapy

Authors: Shen Fu, Jun Hou, Zuofeng LI, Taize Yuan, Qingyuan Zhang, Yuanshui Zheng

Affiliation: GuangZhou Concord Cancer Center, Guangzhou Concord Cancer Center, å¹æå·žę³°å’Œč‚æē˜¤åŒ»é™¢

Abstract Preview: Purpose: A visual feedback system is beneficial for patients to maintain consistent respiratory signal during gated radiotherapy, especially for intensity modulated proton therapy (IMPT) where motion ...

Improvement of Spine Phantom for MR Imaging of the Spine

Authors: Richard Dortch, Thammathida Ketsiri, Zhiqiang Li, Shiv P. Srivastava

Affiliation: Barrow Neurological Institute, Dignity Health Cancer Institute, St. Joseph's Hospital & Medical Center

Abstract Preview: Purpose: Imaging the spinal cord post-surgery is challenging due to metal surgical implants, which induce signal loss and geometric distortions. Together, this hinders the visualization of the spinal ...

Improving 4D-MRI Parameters for Abdominal Tumor Motion Management: A Phantom Study

Authors: Morgan Aire, Krystal M. Kirby, Olivia Magneson, David E. Solis

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: For soft-tissue abdominal tumors, a 4D-MR may provide improved tumor tracking over the clinical standard 4D-CT. This project aims to optimize a clinically available 4D-MR pulse sequence to ac...

Integrating Knowledge-Based Planning with Ethos 2.0 for High-Quality Online Adaptive Lung SABR

Authors: Shahed Badiyan, Chien-Yi Liao, Mu-Han Lin, Dan Nguyen, Justin D. Visak, Hui Ju Wang, Brien Timothy Washington, Kenneth Westover, Yuanyuan Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Knowledge-based planning (KBP) plays a crucial role in improving treatment plans by leveraging previous clinical data to guide new cases. KBP is applied to the Ethos 2.0 Intelligent Optimizat...

Integrating Large Kernel Attention Mechanism into Deep Learning Model for Automatic and Auccrate Segmentation of Gross Tumor Volume in Lung Cancer Patients

Authors: Xuezhen Feng, Li-Sheng Geng, Haoze Li, Xi Liu, Tianyu Xiong, Ruijie Yang

Affiliation: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, School of Physics, Beihang University, School of Nuclear Science and Technology, University of South China, Department of Radiation Oncology, Peking University Third Hospital

Abstract Preview: Purpose: This study aimed to develop a deep learning-based algorithm for automatically delineate gross tumor volume (GTV) for lung cancer patients, alleviating the workload of radiologists and improvi...

Inter-Patient Adaptive Radiotherapy (IPART): A CT Simulation and Planning Free Approach Enabling Immediate Treatment Access for Patients.

Authors: Bin Cai, Andrew R. Godley, Brian A. Hrycushko, Heejung Kim, Mu-han Lin, David D.M. Parsons, Justin D. Visak, Da Wang, Tingliang Zhuang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: The standard radiation therapy workflow requires CT-simulation and planning, whether for initial treatments or re-planning due to significant anatomical changes. IPART instead uses one patien...

Inter-Patient Registration Methods for Voxel-Based Analysis in Lung Cancer

Authors: Chloe Min Seo Choi, Joseph O. Deasy, Jue Jiang, Sudharsan Madhavan, Nikhil Mankuzhy, Nishant Nadkarni, Andreas Rimner, Maria Thor, Harini Veeraraghavan, Abraham Wu

Affiliation: University of Freibrug, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Voxel-based analysis (VBA) requires accurate topology-preserving inter-patient deformable image registration (DIR). This study assessed whether guiding a DIR method with geometric priors of t...

Interplay of Relative Biological Effectiveness and Dose Rate in Eye Plaque Brachytherapy with Low Energy Photons

Authors: Alexei V. Chvetsov, Sunan Cui, Sunyoung Jang, Robert D. Stewart

Affiliation: University of Washington and Fred Hutchinson Cancer Center, Penn State College of Medicine, University of Washington

Abstract Preview: Purpose: To evaluate spatial variation of relative biological effectiveness (RBE) in COMS (Collaborative Ocular Melanoma Study) eye plaques with low energy 125I and 103Pd photon sources as a function ...

Intraoperative Dynamic Contrast-Enhanced Fluorescence Imaging in Quantifying Tissue Perfusion of Amputation Patients

Authors: Logan M. Bateman, Xu Cao, Jonathan T. Elliott, Lillian A. Fisher, Ida Leah Gitajn, Xinyue Han, Eric R. Henderson, Shudong Jiang, Jessica M. Sin, Yue Tang

Affiliation: Dartmouth College, Dartmouth-Hitchcock Medical Center

Abstract Preview: Purpose: Adequate tissue perfusion is essential for fracture healing and infection prevention, as it supplies oxygen, nutrients and antibiotics to the injury area. However, current methods of assessin...

Introduce a Novel Spot-Scanning Proton Arc(SPArc) Optimization Algorithm for Single Energy Extraction(SEE) Synchrotron-Accelerator-Based Proton Therapy System (PTS)

Authors: Xiaoda Cong, Xuanfeng Ding, Gang Liu, Peilin Liu, Jiajian Shen

Affiliation: Department of Radiation Oncology, Mayo Clinic, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Corewellhealth William Beaumont University Hospital

Abstract Preview: Purpose: This study aims to develop the first SPArc optimization algorithm based on the Dynamic Programming (SPArc-DP), to improve the treatment delivery efficiency for synchrotron-accelerator-based P...

Investigation of Flash Proton Irradiation Induced DNA Double Strand Breaks Under Different Free Radical Scavenger Environments

Authors: Hansong Bai, Peter Jermain, Xun Jia, Heng Li, Devin Miles, Daniel Sforza, Michael H. Shang, Daniel Robert Strauss, Keith Unger, Lingshu Yin

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, MedStar Georgetown University Hospital, Johns Hopkins University, Department of Radiation Medicine, MedStar Georgetown University Hospital

Abstract Preview: Purpose: To investigate DNA Double Strand Break (DSB) induced by FLASH proton irradiation in a repair-free plasmid DNA model under different free radical scavenging conditions in plateau and Bragg pea...

Investigation of Low Iodine Concentration Detectability of Dual-Energy CT Imaging Using a Customized 3D Printed Phantom

Authors: Michalis Aristophanous, Laura I. Cervino, Maria F. Chan, Puneeth Iyengar, Hsiang-Chi Kuo, Nancy Y Lee, Xiang Li, Seng Boh Gary Lim, Usman Mahmood, Jean M. Moran, Jason Ocana

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To determine the limits of iodine concentration detection (LOD) and quantification (LOQ) in dual-energy computed tomography using a 3D printed phantom while considering different background, ...

Investigation of Triggered Imaging and Auto Beam Hold Using a Dynamic Thorax Phantom for Intra-Fraction Motion Management

Authors: Liu Hong, Zhong Su

Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)

Abstract Preview: Purpose: During treatment delivery on TrueBeam platform 2.7, Triggered Imaging (TI) enables kV images acquisition at regular intervals and Auto Beam Hold (ABH) provides beam pausing if the target is m...

Iodine Quantification on a Prototype Deep Silicon Photon-Counting Versus Dual-Energy Energy-Integrating Detector CT

Authors: Meghan Lubner, Aria M. Salyapongse, Teva Shapiro, Scott D. Slavic, Timothy P. Szczykutowicz, Giuseppe Toia, Zhye Yin

Affiliation: GE HealthCare, Departments of Radiology and Medical Physics, University Wisconsin-Madison, GE Healthcare, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison, University of Wisconsin Madison, Department of Radiology

Abstract Preview: Purpose:
To compare iodine quantification on a prototype deep silicon photon-counting detector (PCD) CT and conventional clinical energy-integrating (EID) dual-energy (DE) CT.
Methods:
A phan...

Joint Optimization of Patient-Specific Range Modulators and Beam Intensities for Conformal Flash Proton Therapy

Authors: Hao Gao, Jiayue Han, Wangyao Li, Yuting Lin, Jufri Setianegara, Aoxiang Wang, Yanan Zhu

Affiliation: Department of Biomedical Engineering, Huazhong University of Science and Technology, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Proton therapy leverages Bragg-peak-based dose delivery to achieve ultra-high-dose-rate FLASH with patient-specific range modulators (PSRM). Current proton FLASH (pFLASH) planning typically i...

LLM-Enhanced Multi-Modal Framework for Predicting Pain Relief of Stereotactic Body Radiotherapy for Spine Metastases Using Clinical Factors and Imaging Reports

Authors: John Byun, Steven D Chang, Mingli Chen, Cynthia Chuang, Xuejun Gu, Melanie Hayden Gephart, Yusuke Hori, Hao Jiang, Mahdieh Kazemimoghadam, Fred Lam, Gordon Li, Lianli Liu, Weiguo Lu, David Park, Erqi Pollom, Elham Rahimy, Deyaaldeen Abu Reesh, Scott Soltys, Gregory Szalkowski, Lei Wang, Qingying Wang, Zi Yang, Xianghua Ye, Kangning Zhang

Affiliation: Department of Radiation Oncology, Stanford University, Department of Neurosurgery, Stanford University, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: Accurate prediction of pain relief is crucial in determining the clinical effectiveness of Stereotactic body radiotherapy (SBRT) regimen for spine metastases. We propose a deep-learning frame...

Longitudinal CMR Strain Analysis of Right Ventricular (RV) Function across Aging in Offspring of Baboons Exposed to Moderate Maternal Undernutrition

Authors: Geoffrey D. Clarke, Laura A. Cox, Alexander J Moody, Peter W Nathanielsz, Bowen Yang

Affiliation: Wake Forest University School of Medicine, University of Texas Health Science Center at San Antonio, Texas Biomedical Research Institute

Abstract Preview: Purpose:
Recent studies show diagnostic value of myocardial strain analysis for left ventricular (LV) function using cardiac magnetic resonance imaging (CMR). RV function analysis is more challengi...

MC-Dolce: Monte Carlo-Based System for Dose and Linear Energy Transfer Calculations Engine for Carbon-Ion Radiotherapy

Authors: Min Cheol Han, Jin Sung Kim, Seok Ho Lee, Gahee Son, Yongdo Yun

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Hanyang University, Department of Integrative Medicine, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine

Abstract Preview: Purpose: This study aims to develop the MC-DOLCE, a Monte Carlo (MC)-based system capable of calculating physical and biological dose distributions, as well as linear energy transfer (LET) distributio...

MRI Radiomics-Based Machine Learning Model for Predicting BNCT Treatment Response in Glioblastoma

Authors: Huang Chi-Shiuan, Wu Chih-Chun, Hui-Yu Cathy Tsai, Chen Yan-Han, Chen Yi-Wei, Pan Yi-Ying

Affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, Taipei Veterans General Hospital, Tri-Service General Hospital

Abstract Preview: Purpose:
This study aims to develop and validate a machine learning (ML) model based on MRI-derived radiomic features to predict progressive disease (PD) in glioblastoma (GBM) patients four months ...

Machine Learning Knowledge Based Planning Model for Hypo Fractionated Prostate/Prostate Lymph Nodes Treatments

Authors: Nina Burbure, Tawfik G. Giaddui, Shidong Li, Curtis Miyamoto, Jeremy Price, Bin Wang

Affiliation: FCCC at Temple University Hospital

Abstract Preview: Purpose: To evaluate the performance of KBP models for hypo-fractionated prostate and pelvic lymph nodes (LN) VMAT plans.
Methods: A KBP model (TUH KBP) was developed in Eclipse treatment planning ...

Mask Guided Diffusion Model for Metal Artifacts Reduction

Authors: Shusen Jing, Qihui Lyu, Dan Ruan, Ke Sheng, Qifan Xu

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Metallic implants can significantly distort sinograms, leading to severe artifacts in computed tomography (CT) reconstructions. Reconstructing CT images containing metal is fundamentally an i...

Maximizing Integrated Treatment Planning Tools to Increase Automation for X-Ray-Based Adaptive Lung Sabr

Authors: Shahed Badiyan, Chien-Yi Liao, Mu-Han Lin, David D.M. Parsons, Justin D. Visak, Brien Timothy Washington, Kenneth Westover, Yuanyuan Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX

Abstract Preview: Purpose: Adaptive radiotherapy (ART) programs are resource-intensive due to their technical complexities, requiring highly skilled planners. Leveraging integrated automated treatment planning system (...

Measurement of 90 Y Bremsstrahlung Dose with Thermoluminescent Dosimeters

Authors: David P. Adam, Bryan Bednarz, Tyler J Bradshaw, Wesley S. Culberson, Clifford G. Hammer, Sean Jollota, Ohyun Kwon, Jordan Teague

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiology, University of Wisconsin - Madison

Abstract Preview: Purpose: To quantify absorbed dose to water from 90YCl using thermoluminescent dosimeters (TLDs) and to acquire partial volume corrections for 90YCl positron emission tomography (PET).
Methods: Six...

Medical Data Handler: A Research-Oriented Graphical User Interface for Dicom Processing, Image Analysis, and Data Management

Authors: Andrew R. Godley, Steve B. Jiang, Mu-Han Lin, Austen Matthew Maniscalco, Dan Nguyen, Yang Kyun Park

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Preparing DICOM datasets for research and education is challenging due to the complexity of the format and the necessity for patient-specific handling. Existing workflows demand substantia...

Medical Physics Postdoctoral Research As an EntrƩe into the Profession: Results of a Survey Administered By the AAPM Medical Physics Graduate Education Subcommittee

Authors: Abdullah A. Alshreef, Elizabeth L. Bossart, Ashley Cetnar, Leonard H. Kim, Neil A. Kirby, Anna E. Rodrigues, Xin Wang, You Zhang

Affiliation: University of Miami, The University of Texas MD Anderson Cancer Center, Loma Linda University Medical Center, MD Anderson Cancer Center at Cooper, Cooper Medical School of Rowan University, The Ohio State University - James Cancer Hospital, UT Health San Antonio, Duke University, 5940 forest park road

Abstract Preview: Purpose: AAPM TG-298 reported several concerns regarding the training and education of alternative pathway candidates. Medical physics postdoctoral research, though not part of the certification pathw...

Mobetron Quality Assurance Tools

Authors: Robert A. Dahl

Affiliation: Mayo Foundation

Abstract Preview: Purpose: To develop tools to simplify/accelerate the quality assurance testing of the Mobetron mobile linear accelerator and increase safety when moving it to different OR’s.

Methods: The Mobet...

Modeling Alpha-Particle Dose from Diffusing Alpha-Emitters Radiation Therapy in Tissue with Inhomogeneous Diffusion

Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang

Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (ā€œAlpha DaRTā€) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...

Monitor Unit (MU) Substructure Analysis for Low MU Deliveries

Authors: Indra J. Das, Ahtesham U. Khan, Andrew J. White, Poonam Yadav

Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine

Abstract Preview: Purpose: During intensity modulated radiotherapy (IMRT) planning, low MU segments (< 3 MU) are commonly avoided due to documented dosimetric nonlinearity and poor reproducibility. This work aims to ex...

Multi-Center Evaluation of an AI Beam Angle Prediction Model for Liver Treatments Using Pencil Beam Scanning Proton Therapy

Authors: Christopher Ackerman, Chang Chang, Yan-Cheng Huang, Robert Kaderka, Che Lin, Hsin-Chih Lo, Iain MacEwan, Yi-Chin Tu, James Urbanic

Affiliation: University of California San DIego, Taiwan AI Labs, National Taiwan University, California Protons Cancer Therapy Center, University of Miami, Sylvester Comprehensive Cancer Center

Abstract Preview: Purpose: To investigate the performance of an existing AI beam angle prediction model on external patient datasets for liver proton treatments. The AI model was trained on datasets exclusively from on...

Multi-Modality Artificial Intelligence for Involved-Site Radiation Therapy: Clinical Target Volume Delineation in High-Risk Pediatric Hodgkin Lymphoma

Authors: Tyler J Bradshaw, Sharon M Castellino, Steve Y Cho, David Hodgson, Bradford S Hoppe, Kara M Kelly, Andrea Lo, Sarah Milgrom, Xin Tie

Affiliation: Department of Radiation Oncology, University of Toronto, Department of Radiology, University of Wisconsin, University of Colorado Anschutz, Department of Medical Physics, University of Wisconsin, Department of Radiation Oncology, Mayo Clinic, Department of Radiation Oncology, BC Cancer, Vancouver Center, Department of Radiology, University of Wisconsin - Madison, Roswell Park Comprehensive Cancer Center, Emory University School of Medicine

Abstract Preview: Purpose: Clinical target volume (CTV) delineation for involved-site radiation therapy (ISRT) in Hodgkin lymphoma (HL) is time-consuming due to the need to analyze multi-time-point PET/CT scans co-regi...

Multi-Scale, Multi-Task Framework with Jacobian Descent for Multi-Plan Dose Prediction in Sequential Boost Radiotherapy

Authors: Steve B. Jiang, Mu-Han Lin, Yu-Chen Lin, Austen Matthew Maniscalco, Dan Nguyen, David Sher, Xinran Zhong

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, UT Dallas

Abstract Preview: Purpose:
Sequential boost radiotherapy (RT) poses a challenge in allocating dose across multiple plans while protecting organs at risk (OARs). Clinicians must decide whether OAR sparing should occu...

Multidimensional Diffusion MRI Based Microstructural Heterogeneity Model on a 5T MR System

Authors: Jiayi Chen, Shaolei Li, Fuhua Yan, Yingli Yang, Jie Zhang

Affiliation: Department of Radiology, Ruijin Hospital, Institute for Medical Imaging Technology, Ruijin Hospital, Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai United imaging Healthcare Advanced Technology Research Institute, Department of Radiation Oncology, Ruijin Hospital

Abstract Preview: Purpose: The aim of this exploratory study is to investigate the feasibility of establishing a model to explore tissue component heterogeneity using multidimensional diffusion magnetic resonance imagi...

Multimodal Framework for Predicting Radiation-Induced Severe Acute Esophagitis in Esophageal Cancer

Authors: Yeona Cho, Chloe Min Seo Choi, Joseph O. Deasy, Jue Jiang, Jihun Kim, Jin Sung Kim, Nikhil Mankuzhy, Aneesh Rangnekar, Andreas Rimner, Maria Thor, Harini Veeraraghavan, Abraham Wu

Affiliation: University of Freibrug, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Memorial Sloan Kettering Cancer Center, Yonsei University

Abstract Preview: Purpose: We hypothesized that combining clinical, imaging, and radiotherapy dose-distribution features could increase predictive model accuracy in radiation-induced severe acute esophagitis (SAE) in e...

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Authors: Houssam Abou Mourad, Christopher Ackerman, Stephen Adler, Kirk Aduddell, Muhammad K. Afghan, Hamid G. Aghdam, Diego Aguilar, Kang-Hyun Ahn, Francis Ai, Hua Ai, Ray Anthony Aikens, Manik Aima, Victoria Ainsworth, Erfan Akbari, Blessing Akinro, Rani Al-Senan, Khalid Alabbasi, Sam Alam, Daniel Alexander, Mohammed H. Aljallad, Mazin T. Alkhafaji, Ahmad K. Alkhatib, Scott J. Alleman, James Logan Allen, Ibtisam Almajnooni, Tiba Alnaqshabandi, Murat Alp, Stephen J. Amadon, Riska Amilia, Ala Amini, Shiho Amster, Mason R. Anders, Erin Angel, Ledi Anggara, John A. Antolak, Debora Antonio, Felicity Appiah, Haiqa Arain, Lahcen Arhjoul, Ali V. Aritkan, Muhammad Arshad, Mark E. Artz, Nathan S. Artz, Frank A Ascoli, John R. Ashburn, Benjamin Astarita, Masakazu Atsumi, Rex G. Ayers, Tara M. Bachman, Nina L. Bahar, Bing Bai, Michael J. Bailey, Chris Baird, Mohammad Bakhtiari, Andrew J. Ballesio, Isabel Balvoa, Qinan Bao, Jeffrey J. Barbarits, Joseph Barbiere, Philip C. Bardos, Gary T. Barnes, John C. Barrett, Divya Bartley, Steven J. Bartolac, Robert Barton, Christopher P. Bass, Loni Bates, Alan Baydush, John E. Bayouth, Stephen Beach, Kevin Beaudette, Kaelyn Becker, Natalie A. Beckmann, Colleen Beer, Sepideh Behinaein, Jake M. Bell, David M. Bellezza, Maria R. Bellon, Ahmed Benelfassi, Stephanie Louise Bennett, Todd Bernath, Kate Bevins, Nicholas B. Bevins, Brian J. Bismack, David Blaich, Anthony P. Blatnica, Joseph W. Blickenstaff, Steven Blum, Maggie Bobbett, Dayna Bodensteiner, Daniel Boedeker, Robert C. Boggs, Jason D. Bond, Sjirk N. Boon, Jennifer M. Borsavage, Ryan J. Bosca-Harasim, Ryan J. Bosca-Harasim, Satya R. Bose, Todd Bossenberger, Cristina Boswell, Djamal Boukerroui, Christopher M. Bowen, Aaron Brammer, Rich Brancaleoone, Eric Brass, Luis Bravo, William Breeden, Christina Breeze, Eric E. Brost, Justin L. Brown, Karen L. Brown, Marissa Brown, Norman Lee Brown, Payton Brown, Patrick V. Brunick, Ryan Brunkhorst, Gwendolyn P. Brunner, Camelia E. Bunaciu, Maria Bunta, Olwen Burton, Karim Butalag, Priscilla F. Butler, Angela Cagwin, Jeffrey L. Campbell, Warren G. Campbell, Tyler Cantrell, Xu Cao, Yanan Cao, Peter F. Caracappa, Amanda M. Caringi, Joe Caron, Joshua Carter, Kenneth W. Cashon, Sarah Castillo, Everett Cavanaugh, Suran Chae, Abhi Chakrabarti, PhD, Philip Chan, Jina Chang, Sha X. Chang, Youssef M. Charara, Pierre E. Charpentier, Priyanka Chaudhary, Senthamil Selvan Chelliah, Chen Chen, Doris Chen, Kuan Ling Chen, Max Chen, Mingyue Chen, Mu Chen, Xinan Chen, Yie Chen, Yong Chen, Caroline Cheney, Shyh-Shi R. Chern, Stephen Thomas Chesser, Kin Man Cheung, Pai-Chun Melinda Chi, Yuwei Chi, Omar Chibani, Hung Ching, Gwi Ae Cho, Jongmin Cho, David Choi, Wing Yan Choi, Nitish Chopra, Daniel Christ, Olav I. Christianson, Emmanuel Christodoulou, Heeteak Chung, Sophia Claudio, Arely Clavel, William J. Clouse, Gilad Cohen, Michael S. Cohen, Vladimir Collantes, Jason Collier, Jacob Collins, Daria C. Comsa, Charles Conduah, Virgil N. Cooper, Anita M. Corrao, Frank D. Corwin, Mihaela Cosma, Ben Coull-Neveu, Mary K. Cox, Daniel F. Craft, Steven D. Crawford, Troy M. Crawford, Charles E. Creagh, Beatrice Croteau, Camille Crumbley, Wilbert F. Cruz, Guoqiang Cui, J. Adam M. Cunha, Scott Cupp, Bruce H. Curran, Jordan McCauley Cutsinger, Alita D Almeida, Harold DSouza, Nana Dabo-Akoteng, Robert Dahl, Shaun W. Dahl, Ghayath Dakkouri, Malek Daneshvarnezhad, Mylinh Dang, Matt Daniels, George M. Daskalov, David A. Davenport, Amanda Davidek, Scott E. Davidson, Maria De Ornelas, Dylan A. DeAngelis, Mike Deady, Daniel Dean, Savannah Decker, Savannah Decker, Michael Delafuente, Omer Demirkaya, Logan Dempsey, Marc Dennis, Viv Dennis, Dana Derby, Garron A. Deshazer, Veronique Destombes, Ajaya K. Devabhaktuni, Suneetha Devpura, James A. Deye, Shalmali Dharmadhikari, Dominic J. DiCostanzo, Richard V. DiPietro, Emily Diller, Lei Ding, Nayha V. Dixit, Charles Dodge, David N. Dodoo Amoo, Shana Donchatz, Lei Dong, Elangovan Doraisamy, Jennifer E. Dorand, Sarah Driver, Jiayi Du, Michael Duax, Ibrahim M. Duhaini, Ibrahim Duhaini, Kristen Duke, Richard Dunia, Leon Dunn, Shannon R. Durfee, Brittany Earl, Behzad Ebrahimi, Colton Eckert, Hisham Elasmar, John G. Eley, Abdelhamid Elfaham, David C. Ellerbusch, Scott J. Emerson, Sara Endo, David Erickson, Freddy Escorcia, Caroline Esposito, Patrice Essien, Adam Evearitt, Benjamin Fahimian, Liliosa C. Fajardo, Kevin Fallon, Guoqing Fan, Jiahua Fan, Mingdong Fan, Pei Fan, Bing Fang, Jian Fang, Yile Fang, Marc A. Felice, Ye Feng, Michele Sutton Ferenci, Philippe Feru, Jade Alecia Fischer, Aaron Fishbein, Caitlyn M. Fitzherbert, Damian Fondevila, Grant Fong, Robert Wesley Foster, Luke Fourie, Jeffrey Brian Fowlkes, Alexandre Franca Velo, D. Jay Freedman, Ronald W. Frick, Jie Fu, Samuel Fulton, Kamalakar Gaddam, Justin D. Gagneur, Mariana Gallo, Mariana Gallo, David Gammel, Robert G. Gandy, Junfang Gao, Yiming Gao, Victor L. Garcia, Michael Garcia-Alcoser, Jeffrey Garrett, Steven Anthony Gasiecki, Keith Gatermann, Avinash Gautam, Bhoj Gautam, Olivier Gayou, Andrew J. Gearhart, Paul B. Geis, Renil B. George, David P. Gierga, Robert Gilliam, James Giltz, Eric L. Gingold, Frederic Girard, Garth Gladfelder, Sharon Glaze, Brendan K. Glennon, Steven P. Glennon, Guy Godwin, David Lloyd Goff, Lisa M. Goggin, Daniel Goldberg-Zimring, Edward Joseph Goldschmidt, Ehsan Golkar, Angel Gomez, Jason Gong, Manish K. Goyal, Frank Graeff, Royce L. Gragg, Jonathan Gray, Alexander D. Green, Olga L. Green, Andrew Christopher Greene, Travis Greene, Jared Grice, Kevin T. Grizzard, Suveena Guglani, Jeffrey B. Guild, Patrick P. Guo, Sandesh Gupta, Megan Gute, Jonathan Ha, Rachael L. Hachadorian, Christopher Haddad, Lubomir Hadjiiski, Scott W. Hadley, Tomoe Hagio, Kelsey Hall, Logan P. Hall, Klaus A. Hamacher, Amineh Hamad Khatib, Amineh O. Hamad Khatib, Brian R. Hames, Carnell Hampton, Samuel S. Hancock, Robyn S. Handschuh, Jeremy Hansen, Paul Harden, Joseph Harms, Daniel P. Harrington, Carley Harris, Jamie Marie Harris, Jennifer Hart, Richard P. Harvey, Jeremy Hawk, Naoki Hayashi, Maria Laura Haye, Katherine Hazelwood, David Hearshen, Bret H. Heintz, Adam Henry, Frank William Hensley, Michael Chris Hermansen, Marissa Hernandez, Nadia Hernandez, Dayadna Hernandez Perez, Sarah Hetherington, Emily Hewson, Maynard High, Brian P. Hill, Charles B. Hill, Yunsil Ho, Simeon Hodges, David M. Hoeprich, Michael N. Hoff, Robert F. Hoffman, Russell Holden, Clay Holdsworth, Scott Hollingsworth, John R. Holmes, Steve Holmes, Neal S. Holter, Thomas M. Holtschneider, Amirul Hoque, Sabbir Hossain, Tyler S. Howlin, Andrew Robert Hoy, An Ting Hsia, Hao-Yun Hsu, David Hu, Tom C. Hu, Yu-Chi Hu, Long Huang, Mi Huang, Joshua Hubbell, Michael J. Huberts, Julie C. Hudson, Geoffrey Hugo, Donglai Huo, Justin D. Hurley, Martina H. Hurwitz, Mohammad NASEEM Hussain, Andrew Hwang, Ui-Jung Hwang, Joe Ianni, Geoffrey Ibbott, Khalil Ibrahim, Ileana Iftimia, Mohammad Islam, Oleksandra Ivashchenko, Keyvan Jabbari, Joshua Jackson, Joshua Jackson, Ferenc Jacso, Mary Ellen Jafari, Karim Jaffer, Amit Jain, Ngoneh Jallow, Sachin R. Jambawalikar, Joshua A. James, Sunyoung Jang, Desiree Jangha, Tomaj Javidtash, Jun-Hsuang Jen, Peter Jenkins, Todd P. Jenkins, Andrew R. Jensen, Mads Lykke Jensen, Hosang Jin, Bowen Jing, Danielle Marie Johnson, Joshua D. Johnson, Holly Johnston, Kevin Jones, Badal R. Juneja, Nikhil Sriram Kabilan, Robert Kaderka, Jaclyn Kain, Faraz Kalantari, Maduka M. Kaluarachchi, Ali Kamen, Amrit Kaphle, Alireza Kassaee, Saravjeet Kaur, Vaiva Kaveckyte, Linda A. Kelley, Katelyn Kelly, Kathryn Elise Bales Kelly, Delsin B. Khan, Om Khanal, Maksud Khatri, William Steadman Kiger, Bryan Kim, Jong Oh Kim, Sangroh Kim, Sophia Kim, Brian W. King, Erica Kinsey, Assen S. Kirov, Marc T. Kleiman, Matic Knap, Robert J. Kobistek, Inger-Karine Kolkman-Deurloo, Erika Kathryn Kollitz, Dramane Konate, Xiang Kong, Walter Kopecky, Sandra Kos, Nataliya Kovalchuk, Shane Krafft, James A. Kraus, Robert Krauss, Deae-eddine Krim, Serguei Kriminski, Kerry T. Krugh, Lichung Ku, Esra Kucukmokroc, Randi Kudner, Andrew T. Kuhls-Gilcrist, Antti Juhani Kulmala, Akila D. Kumarasiri, Zacariah E. Labby, Taylor Lackey, Edcer Jerecho Laguda, Thang Lam, Michael A. S. Lamba, Kara Lambson, Laurel Zenaida Larramendi, Andy D. Lau, Wolfram Laub, Tyler Laugh, Robert P. Laureckas, Donald Laury, Patricia Lavey, Ashlie Laydon, Adam LeVay, Brandon Lee, Brian Lee, Dong-Chang Lee, Ji Hyun Lee, Jui-Min Lee, Bryan Lemieux, Matthew Lesher, Nicole Leslie, Etienne Lessard, Trish Lewis, Alan Li, Alexander N. Li, Hui Li, Jenny Li, Jiaxin Li, Qiongge Li, Taoran Li, Xiang Li, Yanlong Li, Zisheng Li, Xing Liang, Yun Liang, Chien-Yi Liao, Karisa Liaw, Sung-Yen Lin, Tiffany Lin, Holly M. Lincoln, Lin Ling, Chang Liu, Shaohua Liu, Yu Liu, Chih-Ming Mark Lo, Eric Lobb, Dilson Lobo, Virginia L. Lockamy, Lauren C. Long, Nelia S. Long, Troy Long, Michele Loscocco, Thomas Lowinger, Cynthia Lu, Minghui Lu, Winnie Lu, Yonggang Lu, Jianqiao Luo, Pei-Chin Luo, Xuhan Luo, Jan Luse, Daniel A. Lutterman, Dang Hoang Oanh Luu, Yulia Lyatskaya, Trina Lynd, Morgan Cervo Lyon, Chi Ma, Jingfei Ma, Tianjun Ma, Laurie Madden, Gregory E. Madison, Kurt Maffei, Michael J. Maffett, Nyasha G. Maforo, Dennise Magill, Emma Magness, Alphonso W. Magri, Dennis Mah, Usman Mahmood, Rebecca N. Mahon, Courage Mahuvava, Andrew D. Maidment, Gerassimos M. Makrigiorgos, Harish K. Malhotra, Kate Mallory, P. Scott Mange, Vivek Maradia, Jacob Marasco, Camilla Marino, Loren R. Marous, Wagner Marques, Craig M. Marsden, Edward I. Marshall, Jonathan Marshall, Caroline Martel, Colin Martin, Alejandro Martinez, Jeffrey P. Masten, Richard Mathew, Bobby Mathews, Anetia S. Matthews Jackson, Matthew R. Maynard, Joel R. McAllister, Rafe McBeth, James A. McCulloch, Kiernan T. McCullough, Keelin McGee, Kiaran P. McGee, Brian M. McGill, Christopher M. McGuinness, Robert McKoy, Steven M. McQuiggan, Lacey Medlock, Chirag D. Mehta, Nancy Meiler, Robert Meiler, Matthew A. Meineke, Caroline Melancon, Daniel S. Meleason, Carolyn Meltzer, Chunhua Men, Stephanie Merkl, Michael Merrick, Keith A. Michel, Georgeta Mihai, Ana Mihail, Devin A. Miles, Edward J. Miller, Elizabeth A. Miller, Ronaldo Minniti, Linda Minor, Filmon Misgina, Ajeet Kumar Mishra, Chad Mitchell, Drew P. Mitchell, Gregory S. Mitchell, Jessica Mitchell, Jacqueline Moga, Uwe Mollenhauer, Julien-Fabrice Ngoune Momo, Emi Mondragon, Nicholas Mongillo, Victor J. Montemayor, Scott Montgomery, Diego Luis Montufar Hidalgo, Mohammadamin Moradi, Serban Morcovescu, Jill Anna Moreau, Terrance Moretti, Toby Morris, Courtney K. Morrison, Alexander Albert Morrow, Jill Moton, Jonathon Mueller, Reshma Munbodh, Daniel W. Mundy, Daniela Murgulet, Scott A. Murphy, Benjamin C. Musall, Jana E. Musgrove, Samantha Musial, Yong Hum Na, Joel Nace, Paul Naine, Justin Napolitano, Vrinda Narayana, Ganesh Narayanasamy, Moulay Ali Nassiri, Muhammad Naveed, Richard D. Nawfel, Ritish Nedunoori, Aaron Nelson, Kristin J. Nelson, Aaron Nelson, MD, Neerajan Nepal, Emily Neubauer Sugar, Shree Neupane, David Newey, Mark Newpower, Susan Ng, Bau H. Nguyen, Daniel J. Nicewonger, Xingyu Nie, Ethan Nikolau, Kevin D. Nitzling, Kai Niu, John M. Noll, Prashanth K. Nookala, Khalid Noori, James T. Norweck, Hamidreza Nourzadeh, Jessica L. Nute, Sebastiaan Nysten, Kevin OGrady, Ceferino Obcemea, Keith Ober, Jacqueline Ogburn, Timilehin Ogunbeku, Mina Okello, Brian Olson, Martin Keane Ongeti, Savannah Orrill, Joseph Ott, Bahadir Ozus, Jan Pachon, Alexis Paige-Glenn, Jason Paisley, Farideh Pak, Randahl C. Palmer, Kiran Pant, Virginia Pappas, Abby Pardes, So-Yeon Park, Alexis Parker, Karla Parker, Homayon Parsai, Tommy O. Parsons, Pankaj Patel, Amy Patrick, Johnlly G. Pattaserial, Lindsey M. Patton, Taylor J. Patton, Nava R. Paudel, Timothy John Paul, Colin Paulbeck, Olga V. Pen, Cheng Peng, Yuanlin Peng, Carmelo Perez, Dominik PeruŔko, Alexander Pevsner, Douglas Pfeiffer, Melanie Piantino, Daniel Piatigorski, Rajesh Pidikiti, Natalie Piechowska, Greg Pierce, Tina Pike, Donika Plyku, Robert Pohlman, Mariela Adelaida Porras-Chaverri, Subechhya Pradhan, Guillem Pratx, Chris Proctor, Alexander Pryanichnikov, Diane Pugel, Yue Qiu, Adam C. Quinton, Todd Racine, Andrea Radine, Dustin K. Ragan, Balasubramanian Rajagopalan, Kishore Rajendran, Eric V. Ramirez, Mehdi Ramshad, Vijay K. Rana, Brianne Raulston, Amy K. Readshaw, Hailey Reaux, Ian Reineck, Xuemin Ren, Meral L. Reyhan, Davenport Ria, Matthew J. Riblett, Kenneth M. Richardson, Rebecca F Richardson, Matthew Richeson, Ashlyn Rickard, Adam Riegel, Lynn N. Rill, Miguel A. Rios, E. Russell Ritenour, Scott P. Robertson, Marthony L. Robins, Rebecca Robinson Rey, Steve Rodney, Priscila Rodrigues, Edgardo Rodriguez, Tino Romaguera, Emilie Roncali, Joseph E. Roring, Alison R. Roth, Lawrence N. Rothenberg, Nick Rothwein, Kricia Emilia Ruano Espinoza, Damian DG Rudder, Donald R. Ruegsegger, Erwin W. Ruff, Brandon J. Russell, Frederick Rustad, Narayan Sahoo, Jonathan H. Saleeby, Habeeb H. Saleh, Flavio Salinas Aranda, Steffen Sammet, Daniel Sandoval, Aman Sangal, Joseph P. Santoro, Maíra Santos, Alexis Marie Sanwick, Milind Sardesai, Vikren Sarkar, Duminda Satharasinghe, Jessica L. Saunders, Carmen Sawyers, Sarah B. Scarboro, James Scheuermann, Colleen G. Schinkel, Dale Schippers, Joshua William Schlegel, David J. Schlesinger, Charles Ross Schmidtlein, Erich Schmitz, Jose Schneider, Erich A. Schnell, Lisa Schober, Leah Schubert, Michelle L. Schwer, James Seekamp, Jennifer Seger-Paisley, J. Anthony Seibert, Balaji Selvaraj, Raj N. Selvaraj, Meredith A. Semon-Pomposelli, Lasitha Senadheera, Naima Senhou, Christopher F. Serago, Hananiel Setiawan, Shakil B. Shafique, Aarti Shah, Hina Shah, Alok Shankar, Ryan Shanks, Kritika Sharma, Sunil K. Sharma, Jennifer M. Shealy, Ron Sheen, Gina L. Shelton, Mohammad Ullah Shemanto, Zion Sheng, Andrew J. Shepard, Justin R. Sherman, Kaizhong Shi, Xiaolin Shi, J. Allen Shih, Taciana Soares Shiue, Deborah J. Shumaker, Noah Silverberg, Ramon Alfredo C. Siochi, Amogh Sirniirkar, Marlene Skopec, Michael G. Skowronski, Dana Smetherman, Erika Smith, Eileen Sneeden, Jesse Snyder, James C. So, Emilie Soisson, Nima Soltani, Kwang Hyun Song, Liang Song, Xiaoling Song, Jigar B. Soni, Yashvant C. Soni, Jagadeesh R. Sonnad, Michael A. Speidel, Michael P. Speiser, James D. Speitel, Tanya Spellman, Joseph Patrick Speth, Daniel J. Spitznagel, Sara T. St. James, Alexander Stanforth, George Starkschall, James Stebelton, James P. Steinman, Jonathan M. Stenbeck, Robin L. Stern, Patrick D. Stevens, Erika Stewart, Gary Stinnett, Sarah A. Strand, Keith J. Strauss, Kristen Stryker, Edward Sudentas, Kevinraj N. Sukumar, Orhan H. Suleiman, John L. Sullivan, Paul Robert Sullivan, Mei Sun, Peng Sun, Kumari Sunidhi, Jacob Sunnerberg, Elizabeth A. Swanson, William J. Swanson, Larry E. Sweeney, Sean Swiedom, Gregory Szalkowski, Katsuyuki Taguchi, MohammadAli Tajik-Mansoury, Reza Taleei, Derek Tang, Shengzhang Tang, Mahin Tariq, Jason S. Tavel, Neelima Tellapragada, Alexandra Tellez, Dawn Tellez, Juan Manuel Tellez, Xiaokun Teng, James A. Terry, Biniam Tesfamicael, Confex Test, Aapm Tester, Contex Tester, Namita Thakur, David J. Theel, Kathleen D. Thomas, Emily A. Thompson, Stephen K. Thompson, Daniela Thorwarth, Kevin Tierney, Anders Tingberg, Ragu S. Tirukonda, Robert A. Tokarz, Robert J. Tokarz, Naresh B. Tolani, Brian Tom, Shidong Tong, Ebrahim Torangan, Martin Tornai, Diana Tovmasian, Trung Tran, Bryan Traughber, Samuel Trichter, Sugata Tripathi, Petra Trnkova, Panagiotis Tsiamas, Ryan Tsiao, Haifeng Tu, Philip N Tubiolo, Jeff D. Turley, Adam Turner, PhD, DABR, Conner Ubert, Chibueze Zimuzo Uche, Vincent M. Ulizio, Gnanaprakasam Vadivelu, Hema Vaithianathan, Sunil Valaparla, Fabiola Vallejo Castañeda, Liesbeth Vancoillie, Matt Vanderhoek, Caroline Vanderstraeten, Nancy J. Vazquez, Linda A. Veldkamp, Trevor L. Vent, Anthony M. Ventura, Keith Ver Steeg, Irina Vergalasova, CHENG WANG, Christopher Waite-Jones, Matthew C. Walb, Reuben Waldron, Arlie Vester Walker, Jim Walsh, Alisa I. Walz-Flannigan, Cheng Wang, Helen H. Wang, Hui-Chuan Wang, Jiali Wang, Jian-xiong Wang, Kai Wang, Kyle Wang, Ning Wang, Yuntao Wang, Zhendong Wang, Zhixing Wang, Grace Ward, Sarah M. Way, Rachel L. Waymire, Melvin Weatherly, Charles Travis Webb, Lincoln J. Webb, Jia Wei, Wenbo Wei, Callie Weiant, Miriam S. Weiser, Eric M. Welch, Jered R Wells, Michelle C. Wells, S. Brock Westlund, Gerald A. White, John White, Darunee S. Whitt, David Wikler, Austin Wilkinson, Carly D. Williams, Mark Bennett Williams, Joshua M. Wilson, Keli C. Wilson, Nicholai Wingreen, Joseph Wishart, Alon Witztum, Katherine M. Woch Naheedy, Andy Wolf, Serkalem E. Wondimgezhu, Genevieve N. Wu, Wenhao Wu, Ye Wu, Yuxiang Xing, Li Xiong, Weijun Xiong, Xunyi Xu, Yan Xu, Tianyou Xue, Yanjie Xue, Girijesh K. Yadava, Derek Z. Yaldo, Kaiguo Yan, Yue Yan, Nathan E. Yanasak, Bowen Yang, Ray Yang, Xiaocheng Yang, Yun Yang, Yunze Yang, Bin Yao, Yuan (John) Yao, Anna N Yaroslavsky, Feng-Ju Yeh, Susanne Yerich, Michael V. Yester, Xiaofei Ying, Tekeste Yohannis, Tony Younes, Eyesha Younus, Jialu Yu, Justin Yu, Yan Yu, Pui Kuen Yuen, Joshua P. Yung, Steve Yuvan, Mehran Miron Zaini, Ramtin Zakikhani, Lee Anne Zarger, Merissa Zeman, Lisa Zent, Di Zhang, Dongqing Zhang, Hao Zhang, Jun Zhang, Lei Zhang, Lu Zhang, Maochen Zhang, Peng Zhang, Peng Zhang, Qingyun Zhang, Xin Zhang, Yi Zhang, Yinghui Zhang, Yongbin Zhang, Zhongwei Zhang, Bo Zhao, Xuandong Zhao, Yizhou Zhao, Weiping Zheng, Yi Zheng, Troy Zhou, Xiangzhi Zhou, Xiaohong Joe Zhou, Yuwei Zhou, Jin Zhu, Mingyao Zhu, Eric C. Zickgraf, John R. Zullo, Piotr Zygmanski, Leo van Battum

Affiliation: DTC Consultants, NL Health, Dartmouth Hitchcock Medical Center, ProCure Proton Therapy Center, Medical & Radiation Physics, Inc, Augusta University, Genesis Healthcare Partners, Michigan Medicine, Washington DC VA Medical Center, VA Medical Center, Mercy Southeast Hospital, Food And Drug Administration, University of Iowa, Advanced Radiation Physics Service, Inc, University of Pittsburgh, University of Wisconsin, Wellspan Health, Good Samaritan Hospital, Howard University Hospital, St. Mary's Memorial Health Center, Penn State Milton S. Hershey Med Ctr., New York Weill Cornell Medical Ctr, X-Ray Computations, Inc., US Navy, Penn State Health, Kelsey Seybold Clinic, Advocate Aurora, Fresno Cancer Center, Central Alabama Radiation Oncology, Riverside Methodist Hospital Ohio Health, Alliance Medical Physics, OCSRI, AAPM, University of Minnesota, University of Virginia Health System, PGIMER, Barrigel, Johns Hopkins Univ, Appex Physics Partners, BoxElder Research, University of Oklahoma Health Sciences Center, Sanford Roger Maris Cancer Center, Berkshire Medical Center, New York Weill Cornell Medicine, Mobimed Technologies, University of Chicago Medicine, Johns Hopkins Medicine, Maimonides Medical Center, Nuvance Health - Vassar Brothers, Crozer Keystone Health System, Karmanos/McLaren, Vanderbilt University, Panhandle Cancer Care Center, The University of Michigan, Piedmont Healthcare, Gamma Medical Physics LLC, Mississippi Baptist Medical Center, Astarita Associates Inc, Landauer Medical Physics, RPS Oncology, Zhejiang University, University of North Carolina School of Medicine, University of Kentucky HealthCare, Peninsula Regional Medical Center, Varian Advanced Oncology Solutions, New York Proton Center, Wake Forest University Medical Center, Rutgers Robert Wood Johnson Medical School, Tx Oncology, Lewis Hall Singletary Oncology Center (John D. 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Radiation Oncology, Renown Health, Purdue Univ, Beth Israel Deaconess Medical Center, Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Holy Family Hospital, OhioHealth, IBA Dosimetry, Memorial Hospital Gulfport, University of Florida, George Washington Univ, University of Cincinnati Medical Center, Hubbard, Zickgraf, & Broadbent, Accuray Inc, UVRMC, MIM Software, Massachusetts General Hospital and Harvard Medical School, Mem. Sloan Kettering Cancer Ctr, UF Health Proton Therapy Institute, California Medical Physics, Inc., Henry Ford Health, UPMC Hillman Cancer Center, Vanderbilt University School of Medicine, Saddleback Memorial Medical Center, Stony Brook University Medical Center, University of Pennslyvania, TOP Physics Consulting, Nuvance/Norwalk Hospital, Oregon Health & Science Univ, Brigham & Women's Hospital, University of Pennsylvania, McLaren – Greater Lansing, American Board of Radiology, Penn Medicine | Virtua Radiation Oncology, University of Tennessee, OneOncology, University of Colorado, Indiana University Medical Center, Stronach Regional Cancer Centre, Yale New Haven Health, Vanderbilt University Medical Center, Emory Healthcare / Winship Cancer Institute, Cape Fear Valley Radiation Oncology, Northwell Health, Sutter Health, Virginia Mason Medical Center, MUSC Health- Florence Medical Center, Departement of Radiation Oncology, Curie Institute, Paris, University of Michigan, MD Anderson Cancer Center, University of Alabama at Birmingham, Radiology Inc., Cedars Sinai Hospital, Roswell Park Cancer Institute, Duke University Health System, VA Hospital, DVA Medical Ctr., JFK Medical Center, Mount Sinai West, National Cancer Institute, Chung Nam National University Sejong Hospital, Indiana Univesity, AdventHealth Daytona Beach, Orlando Health, Clinical Research Institute HUS, Northwest Medical Physics Center, University of Pennsylvania, Penn Medicine, Kettering Health Network, Children's Mercy Kansas City, IBA, UMass Memorial Hospital, US Oncology, Kaiser Permanente Southern California Medical Group, The Queen's Health System, NewYork-Presbyterian, Miami Valley Hospital, Karlsruhe Institute of Technology, Piedmont Hospital, Accuray Inc., VARIAN - Advanced Oncology Solutions, GE Healthcare, Virtua Health, Northwestern Medicine Chicago Proton Center, CARO/Montgomery Cancer Center, Walter Reed National Military Medical Center, InterMountain Health Care, Englewood Hospital and Medical Center, Henry Ford Health System, Fluke Health Solutions, Texas Oncology, PA, Inova Alexandria Hospital, New Milford Hospital, Fox Chase Cancer Center, Radiation Therapy and Cancer Inst, Penn State College of Medicine, University of California San Francisco, Unity of Oncologic Therapy S.A., Canon Medical Systems USA, Kaiser Permanente, Baptist Health Paducah, Salina Regional Health, Centre d'Oncologie de la Cote Basque, Minneapolis Radiation Oncology, Coastal Carolina Radiation Oncology, Saint Francis Hospital, Advocate Christ Medical Ctr, Universidad de Costa Rica, CAMP, Blessing Hospital, Texas Oncology Cancer Ctr, CommonSpirit Health, Navy Medical Forces Atlantic, Regions Hospital, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Methodist Hospital, Champlain Valley Physicians Hospital, Mayo Clinic Jacksonville, OHSU, Promedica Health System, Arthur JE Child Comprehensive Cancer Centre, Rhode Island Hospital / Warren Alpert Medical, UPMC Pinnacle Health, Vassar Brothers Hospital, McLeod Regional Medical Center, RJ Tokarz MIRS, St. Francis Hospital, Astarita Associates, Inc., UC Davis Medical Center, Mount Nittany Medical Center, Covenant Radiation Center, National Institute of Standards and Technology, AdventHealth Orlando, St Helena Hospital, Icon Cancer Centre, University of Washington, Indiana University, TrueNorth Medical Physics LLC, Medstar Georgetown University Hospital, Harold Alfond Center for Cancer Care, MN Oncology, Jupiter Medical Center, GE HealthCare, Rochester General Hospital, Piedmont Health, Atrium Health, Minneapolis VA Health Care System, CentraCare Health System, OMPC Diagnostic LLC, Evergreen Health Medical Center, CAMC Cancer Center - Beckley, University of Kansas Medical Center, Avera McKennan, Cleveland Clinic, Louisiana Tech University

Abstract Preview: N/A...

Neural Implicit K-Space for Accelerated Patient-Specific Non-Cartesian MRI Reconstruction

Authors: Daniel O Connor, Mary Feng, Hui Lin, Hengjie Liu, Xin Miao, Michael Ohliger, Jess E. Scholey, Ke Sheng, DI Xu, Wensha Yang, Yang Yang

Affiliation: UCSF, University of California, Los Angeles, Department of Radiation Oncology, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, University of California at San Francisco, University of San Francisco, Department of Radiology, University of California, San Francisco, University of California San Francisco, Siemens Medical Solutions USA Inc.

Abstract Preview: Purpose: The scanning time for a fully sampled MRI is lengthy. Compressed sensing (CS) has been developed to minimize image artifacts in accelerated scans, but the required iterative reconstruction is...

Nomogram Based on Interpretable Multiregional Radiomics of Cone-Beam Breast CT and Clinicopathologic Features for Predicting FISH Status in HER2 2+ Breast Cancer to Differentiate HER2-Low from -Positive: A Multi-Center Study

Authors: Keyi Bian, Marco Caballo, Wenxiu Guo, Haijie Li, Jiao Li, Aidi Liu, Yue Ma, Ioannis Sechopoulos, Yafei Wang, Yaopan Wu, Zhaoxiang Ye, Yuwei Zhang, Yueqiang Zhu, Daan van den Oever

Affiliation: Radboud University Medical Center, Tianjin Medical University Cancer Institute & Hospital, Sun Yat-Sen University Cancer Center

Abstract Preview: Purpose: To develop and validate a nomogram integrating intra- and peritumoral radiomics of contrast-enhanced cone-beam breast CT (CE-CBBCT) and clinicopathologic features for predicting fluorescence ...

Non-Planar Narrow-Beam CT: Near Scatter-Free, High-Resolution Breast Imaging at Screening Mammography Doses.

Authors: Peymon Ghazi

Affiliation: MALCOVA Inc.

Abstract Preview: Purpose: To develop a near scatter‐free breast CT imaging system that expands coverage of the posterior breast anatomy and enhances contrast resolution for solid masses and microcalcifications, while ...

Novel Fast Cone-Beam CT for Adaptive Radiotherapy: Assessment of Image Distortion, Auto-Contouring, and Dose Delivery Accuracy in the Presence of Periodic Subject Motion

Authors: David P. Adam, William T. Hrinivich, Taoran Li, Alexander Lu, Michael Salerno, Alejandro Sisniega, Boon-Keng Kevin Teo

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University, University of Pennsylvania

Abstract Preview: Purpose: Cone beam CT (CBCT)-guided online adaptive radiotherapy (ART) is of growing interest, with recent improvements in image quality provided through larger detector panels and fast gantry rotatio...

One Year Experience of Biology-Guided Radiotherapy (BgRT) on PET-Linac in an Academic Center

Authors: Shahed Badiyan, Girish Bal, Thomas I. Banks, Bin Cai, Tu Dan, Aurelie Garant, Andrew R. Godley, Steve Jiang, Orhan Oz, Arnold Pompos, Rameshwar Prasad, Chenyang Shen, David Sher, Robert Timmerman, Kenneth Westover

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: Biology-guided radiotherapy (BgRT) is a novel FDA-cleared technology for treating lung and bone tumors based on 18F-FDG PET uptake. This study summarizes the first-year experience treating 29...

Optimization of Impulsed Acquisition Protocols on 1.5T MRI Using Simulation-Based Bayesian Experimental Design for Cell Size Imaging

Authors: Yan Dai, Jie Deng, Xun Jia, Wen Li, Junzhong Xu

Affiliation: Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiology, Vanderbilt University Medical Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Cell size is a vital parameter in evaluating the tumor microenvironment, including cell apoptosis and radiotherapy(RT)-induced immune cell infiltration. The IMPULSED(Imaging Microstructural P...

Optimizing Dose Coverage and Mitigating Electron Return Effects and Electron Stream Effects in MR-Linac Treatment of Extremity Malignancies: The Impact of Bolus and Gel Use

Authors: Kin Yin Cheung, Chen-Yu Huang, Chi Wah Kong, Ka Ki Lau, Pei-Xiong Li, Darren M. C. Poon, Bin Yang, Siu Ki Yu, Jing Yuan, Chi To Yung, Shang Peng Felix Yung

Affiliation: Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Medical Physics Department, Hong Kong Sanatorium and Hospital, Research Department, Hong Kong Sanatorium and Hospital

Abstract Preview: Purpose: This study investigates optimal treatment strategies utilizing MR-linac for extremity lesions, with a specific focus on a 0.6 cm deep lesion in the right palm. The magnetic field-induced dose...

Optimizing Vessel Wall Visualization Using a Novel Black-Blood CT Technique on Craniocervical CT Angiography

Authors: Xiaohu Li, Jianjun Shen, Guozhi Zhang, Sihua Zhong, Jingjie Zhou

Affiliation: United Imaging Healthcare

Abstract Preview: Purpose:
Visualization of carotid artery vessel wall on computed tomography angiography (CTA) imaging is challenging. This study aims to develop a novel post-processing technique, black-blood compu...

PET Guided Radiation Therapy for Large Planning Target Volume Expansions of Small PET-Active Gross Tumor Volumes

Authors: Sarah Dumont, Trevor Ketcherside, An Liu, William T. Watkins, Qiuyun Xu

Affiliation: RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose:
The RefleXion X1 SCINTIX algorithm convolves beam fluence with real-time PET distributions for tracking and plan adaptation, but radiotherapy Planning Target Volumes (PTVs) are often signi...

Patient-Specific Orthogonal Projection Based Real-Time Volumetric X-Ray Imaging for Proton Therapy

Authors: Hao Chen, Kai Ding, Xiaoyu Hu, Xun Jia, Heng Li, Devin Miles

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Accurately delivering radiation dose is critical in intensity-modulated proton therapy (IMPT), where intrafraction motion management plays a pivotal role. Our proton therapy system equipped x...

Patient-Specific Treatment Plan Optimization through Intentional Deep Overfit Learning As a Warm Start for Longitudinal Adaptive Radiotherapy

Authors: Wouter Crijns, Frederik Maes, Loes Vandenbroucke, Liesbeth Vandewinckele

Affiliation: Department of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven; Department of Radiation Oncology, UZ Leuven, Department ESAT/PSI, KU Leuven; Medical Imaging Research Center, UZ Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven

Abstract Preview: Purpose: To explore intentional deep overfit learning (IDOL) to exploit the initial treatment plan to predict an adaptive radiotherapy plan.
Methods: A conditional generative adversarial network is...

Patient-Specific Ultra-Sparse k-Space Reconstruction Using Motion Decomposition and Sinusoidal Representation Networks for Dynamic Volumetric MRI in Radiotherapy

Authors: Karyn A Goodman, Yang Lei, Tian Liu, Charlotte Elizabeth Read, Jing Wang, Qian Wang, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Beth Israel Deaconess Medical Center

Abstract Preview: Purpose: Accurate motion management in MRI-guided radiotherapy (MRIgRT) relies on real-time volumetric MRI to track intra-fractional anatomical changes. Dense k-space sampling, while capable of produc...

Patterns of Nanoparticle Uptake for Patients with Multiple Brain Metastases: Similarities and Differences to Standard Gbca

Authors: Stephanie Bennett, Ross I. Berbeco, Ning Jin, Sonal Josan, Justin Michael Sheetz, Atchar Sudhyadhom

Affiliation: Department of Radiation & Cellular Oncology, University of Chicago, University of Massachusetts - Lowell, Siemens Healthineers, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Brigham and Women's Hospital

Abstract Preview: Purpose: AGuIX, a Gadolinium-based theranostic radiosensitizing nanoparticle, is currently under clinical evaluation in Europe and the US. Using patients from the double-blinded NanoBrainMets trial, u...

Performance Evaluation of CT-Based Lung Tumor Classification Deep Learning Algorithms Under Centralized and Federated Learning Frameworks

Authors: Yifei Hao, Chengliang Jin, Wenxuan Li, Bing Luo, Tao Peng, Yulu Wu, Fang-Fang Yin, Yue Yuan, Lei Zhang, Ruojun Zhou

Affiliation: School of Future Science and Engineering, Soochow University, Electrical and Computer Engineering Graduate Program, Duke Kunshan University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: Federated learning is a patient privacy-protecting technique that has recently been applied in the medical field. This study aims to evaluate the performance of several deep learning networks...

Performance of Photon Counting Detector in a Clinical PCD-CT: A Novel Image-Based Evaluation

Authors: Frank F. Dong, Megan C. Jacobsen, Ke Li, Xinming Liu, John Rong

Affiliation: UT MD Anderson Cancer Center

Abstract Preview: Purpose: We aimed to understand the physical performance of a CdTe PCD-based detector system within a whole-body PCD-CT scanner, with the goal of optimizing its clinical application. Instead of relyin...

Personalized Anisotropic Margin Strategy for Cervical Cancer Online Adaptive Radiation Therapy

Authors: Jian Chen, Qiufen Guo, Aihua Li, Jing Liu, Junjie MA, Qian WU, Haonan Xiao, Peng Xie, Xiaohui Yan, Yong Yin, Zhe Zhang

Affiliation: Department of Radiation Oncology, Peking University Shenzhen Hospital, Department of Radiation Oncology and Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Obstetrics and Gynaecology, Liao Cheng People’s Hospital

Abstract Preview: Purpose: Online Adaptive radiation therapy (ART) has been an effective technique to manage patient’s inter-fractional anatomical changes and therefore reduces planning target volume (PTV). However, on...

Photon-Counting CT Versus Dual Energy CT for Liver Fat Volume Fraction Assessment

Authors: Chao Guo, Xinhua Li, Michael F. McNitt-Gray, Di Zhang, Yifang (Jimmy) Zhou

Affiliation: UCLA, David Geffen School of Medicine at UCLA, Cedars-Sinai Medical Center

Abstract Preview: Purpose: The objective was to quantify the liver fat volume fraction (FVF) with virtual monochromatic imaging (VMI) using photon-counting CT (PCCT) and dual energy CT (DECT).
Methods: A custom desi...

Planning Study of Spatially Fractionated Radiotherapy (SFRT) for Treating Recurrent Glioblastoma Multiforme (GBM)

Authors: Hyunuk Jung, Fiona Li, Brian Marples, Michael Milano, Sean M. Tanny, Dandan Zheng, Yuwei Zhou

Affiliation: Department of Radiation Oncology, University of Rochester, University of Rochester Medical Center, University of Rochester

Abstract Preview: Purpose:
Recurrent GBM remains one of the most challenging cancers, with limited treatment options. We investigated potential planning parameters of SFRT, a novel radiotherapy technique that delive...

Preclinical Dosimetric Evaluation for Small Animal Study to Investigate Normal Tissue-Sparing Effects in the Electron Ultra-High Dose-Rate (FLASH) Environment

Authors: Ashok Bhandari, Andrew Joseph Fanning, Kyle J. Gallagher, Brendan Graff, Christopher Jenkins, Kyuhak Oh, Ying Yan, Su-Min Zhou

Affiliation: University of Nebraska Medical Center

Abstract Preview: Purpose: This study aimed to design a robust experimental setup to ensure accurate dose delivery using ultra-high-dose-rate for small animal experiments by conducting dosimetric evaluations prior to a...

Predicting Proton Therapy Dose Delivery Accuracy: A Machine Learning Approach Using Iroc’s Proton Phantom Data

Authors: Lian Duan, Stephen F. Kry, Hunter S. Mehrens, Paige A. Taylor

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To develop a machine learning model for predicting dose delivery accuracy and identifying its key factors in IROC’s proton phantom program.
Methods: IROC’s proton QA program has six proton...

Proton Pencil Beam Scanning Ultra-High Dose Rate 3D Lattice Radiotherapy: A Proof-of-Concept Flash Sfrt Study

Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng

Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...

Putting the Gram in Esophagram: A New Metric for Harmonizing Fluoroscopy Doses

Authors: Brendon J. Villegas

Affiliation: University of Alabama Birmingham

Abstract Preview: Purpose: The Cumulative Air Kerma (CAK) has traditionally been a surrogate metric for patient exposure to ionizing radiation during clinical esophagrams. Recently, UAB technologists observed that a ne...

Quantification of Iodine and Calcium Materials through HU Spectral Curve Analysis in Dual-Energy CT for Radiotherapy Planning

Authors: Sean L. Berry, Weixing Cai, Laura I. Cervino, Maria F. Chan, Yabo Fu, Puneeth Iyengar, Hsiang-Chi Kuo, Nancy Lee, Tianfang Li, Xiang Li, Jean M. Moran

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Iodine maps derived from Dual-Energy CT (DECT) provide critical biological information for radiotherapy treatment planning, but clinical iodine maps often mistakenly include bones due to insu...

Quantifying Cervical Cancer Radiotherapy Care Gap in Uganda: Baseline Assessment Prior to Implementation of a Custom Mobile Health App.

Authors: Eric C. Ford, Awusi Kavuma, Solomon Kibudde, Lilie Lin, Apollo Muramuzi, Nibedita Paul, Peniel T Twum, Afua A. Yorke

Affiliation: Uganda Cancer Institute, MD Anderson Cancer Center, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, University of Nebraska, Global Communities

Abstract Preview: Purpose: Sub-Saharan Africa accounts for over one-third of global cervical cancer deaths, despite representing only 14% of the world’s female population. At the only RT center in Uganda, prior studies...

Radionuclide Therapy Patient Release Dose Calculation Using a Non Point Model

Authors: Tianliang Gu

Affiliation: UT Health Science Center at Houston

Abstract Preview: Purpose:
In Nuclear Regulatory Commission guide 8.39 on releasing patients administered radioactive material, the dose is calculated assuming both the source and receiver are points. This point mod...

Radiopathomic Characterization of Chemoradiation Resistance in Preclinical Models of Head and Neck Cancer

Authors: Rico Castillo, Katherine Gonzalez, Casey C. Heirman, Kyle J. Lafata, Xiang Li, Yvonne M Mowery, Yvonne M Mowery, Allison Pittman, Ashlyn G. Rickard, Breylon Riley

Affiliation: Duke University, Department of Radiation Oncology, Duke University, University of Pittsburgh

Abstract Preview: Purpose: To evaluate the relationships between quantitative imaging biomarkers and chemoradiation resistance in head and neck squamous cell carcinoma (HNSCC) using preclinical mouse models.

Met...

Rapid Reconstruction of Extremely Accelerated Liver 4D MRI Via Chained Iterative Refinement

Authors: Mary Feng, Yi Lao, Hui Lin, Hengjie Liu, Xin Miao, Michael Ohliger

Affiliation: University of California, Los Angeles, Department of Radiation Oncology, University of California San Francisco, Department of Radiation Oncology, City of Hope National Medical Center, University of California San Francisco, Siemens Medical Solutions USA Inc.

Abstract Preview: Purpose: 4D MRI with high spatiotemporal resolution is vital to characterize the tumor/tumor motion for liver radiotherapy. However, high-quality 4D MRI requires an impractically long scanning time fo...

Real Time Monte Carlo Dose Calculation for Clinical Cyberknife Radiation Therapy Based on Deep Learning Diffusion Model

Authors: Ruiyan Du, He Huang, Mingzhu Li, Ying Li, Hongyu Lin, Wei Liu, Shihuan Qin, Yiming Ren, Hui Xu, Lian Zhang, Xiao Zhang, Zunhao Zhang

Affiliation: Department of Radiation Oncology, Mayo Clinic, Medical AI Lab, The First Hospital of Hebei Medical University, Hebei Provincial Engineering Research Center for AI-Based Cancer Treatment Decision-Making, The First Hospital of Hebei Medical University, Department of Oncology, The First Hospital of Hebei Medical University

Abstract Preview: Purpose: Monte Carlo (MC) dose calculation is the gold standard in clinical CyberKnife radiation therapy (RT), considering its steep dose gradients and high-freedom non-coplanar beam angles, but extre...

Real-Time Proton and Carbon Ion Monte Carlo Dose Calculation through GPU-Acceleration and DL-Based Denoising Algorithms

Authors: Yankui Chang, Shijun Li, Xi Pei, Ripeng Wang, Xuanhe Wang, X. George Xu, Qing Zhang, Jingfang Zhao

Affiliation: University of Science and Technology of China, Shanghai proton and heavy ion center, School of Nuclear Science and Technology, University of Science and Technology of China, Anhui Wisdom Technology Co., Ltd.

Abstract Preview: Purpose:
This paper describes disruptive methods using both GPU-based MC simulation and deep-learning (DL)-based MC denoising algorithms, as well as clinical tests involving more than 560 patient p...

Region-Specific Structure-Function Coupling Alterations in Parkinson’s Disease: Insights from Multi-Modal MRI

Authors: Yifei Hao, Ting Huang, Wenxuan Li, Xiang Li, Manju Liu, Rong Liu, Tao Peng, Yulu Wu, Fang-Fang Yin, Lei Zhang, Yaogong Zhang, Jiangtao Zhu

Affiliation: Duke University, Department of Radiology, The Second Affiliated Hospital of Soochow University, School of Future Science and Engineering, Soochow University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: This study investigates the alterations in structure-function coupling (SC-FC) networks in Parkinson’s disease (PD) patients, focusing on region-specific disruptions and compensatory mechanis...

Reliable Markerless Lung Tumor Tracking with Built-in Patient-Specific Quality Assurance

Authors: Weixing Cai, Laura I. Cervino, Qiyong Fan, Yabo Fu, Tianfang Li, Xiang Li, Jean M. Moran, Hai Pham, Pengpeng Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: AAPM Task Group Report 273 emphasizes the importance of rigorous validation to ensure the generalizability and robustness of machine learning-based clinical tools before their implementation ...

Report on Common Clinical Workflows and Staffing Models for CTgART

Authors: Mu-Han Lin

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: N/A...

Reproducibility of a Unique Prone Head and Neck Setup Evaluated with In Vivo Epid Dosimetry System

Authors: Salim Balik, Eric Chang, Kristine Garcia, Andrew Islas, Lijun Ma, Zhilei Liu Shen, Elizabeth Zhang-Velten

Affiliation: Radiation Oncology, Keck School of Medicine of USC

Abstract Preview: Purpose: NRG protocols recommend simulating and treating head and neck (HN) cancer patients in a supine position for optimal setup reproducibility. However, certain patients cannot tolerate the supine...

Retrospective Evaluation of Combined Photon SBRT and Radium-223 SPECT Based Radiopharmaceutical Therapy Tumor Dosimetry in Clinical Trial Patient Cases

Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang

Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill

Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...

Robust Estimation of Cell Microstructure Parameters Via Diffusion MRI Cytometry

Authors: Yan Dai, Jie Deng, Xun Jia, Wen Li

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Cell microstructure information is critical for radiotherapy response assessment. Diffusion MRI (dMRI) offers great potential in deriving cell parameters. Yet parameters estimated in existing...

Scan Efficiency and Imaging Dose Analysis of Next-Generation Nonstop Gated CBCT for Respiratory Gating Lung Radiotherapy

Authors: Sean L. Berry, Weixing Cai, Laura I. Cervino, Yusuf Emre Erdi, Yabo Fu, Yiming Gao, Daphna Gelblum, Wendy B. Harris, Xiuxiu He, Tianfang Li, Xiang Li, Seng Boh Gary Lim, Jean M. Moran, Mitchell Yu, Hao Zhang

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Gated CBCT (gCBCT) is commonly employed for respiratory gating lung cancer patients to ensure precise patient setup. However, the scan is time-consuming on C-arm linear accelerators (LINAC) d...

Scissor-Beam Based Carbon Ion Minibeam Treatment Planning Method

Authors: Hao Gao, Qiang Li, Yuting Lin, Wei Wang, Wei Wu, Weijie Zhang

Affiliation: Institute of Modern Physics, Chinese Academy of Sciences, China, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Carbon minibeam radiation therapy (cMBRT) offers high peak-to-valley dose ratio (PVDR) and relative biological effectiveness. A key challenge is balancing uniform target coverage with PVDR pr...

Sensitivity of CT Ventilation Imaging to Image Acquisition and Reconstruction Parameters: A Phantom Study

Authors: Hilary Louisa Byrne, Paul J. Keall, John Kipritidis, Jeremy Lim

Affiliation: Northern Sydney Cancer Centre, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney

Abstract Preview: Purpose:
Non-contrast CT ventilation imaging (CTVI) has been developed as a cost-effective and accessible alternative to PET/SPECT V/Q imaging for visualizing lung function. However, the sensitivit...

Single Plane Positioning Tracking Proton and Helium Pencil Beam Radiographs: Phantom Study

Authors: Anahita Bakhtiari Moghaddam, Don F. DeJongh, Ethan DeJongh, Jennifer Hardt, Oliver JƤkel, Lukas Martin, Alexander Pryanichnikov, Joao Seco, Christina Stengl, Niklas Wahl

Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), ProtonVDA LLC, Department of Physics and Astronomy, Heidelberg University, Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT)

Abstract Preview: Purpose:
To evaluate the feasibility and performance of single-plane position tracking for proton and helium pencil beam radiography using a prototype imaging system, with the goal of providing a c...

Small Fields Output Factor Measurements in 1.5 MR-Linac

Authors: Thomas I. Banks, Tsuicheng D. Chiu, Viktor M. Iakovenko, Christopher Kabat, Chang-Shiun Lin, Mu-Han Lin, Arnold Pompos

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX

Abstract Preview: Purpose: The superior soft-tissue contrast provided by MR imaging offers favorable conditions for the effective application of stereotactic body radiation therapy (SBRT). Accurate small field dosimetr...

Small but Mighty: A Lightweight and Computationally Efficient Model for Deformable Image Registration

Authors: Hengjie Liu, Dan Ruan, Ke Sheng, DI Xu

Affiliation: Physics and Biology in Medicine, University of California, Los Angeles, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, Los Angeles

Abstract Preview: Purpose:
State-of-the-art deep learning-based deformable image registration often uses large, complex models directly adapted from computer vision tasks but achieves only comparable performance to ...

Sources of Magnetic Susceptibility Artifacts in MR Imaging of the Jaw and Facial Nerves

Authors: Avneesh Chhabra, Zhiyue J. Wang, Qing Yuan

Affiliation: University of Texas Southwestern Medical Center

Abstract Preview: Purpose: Magnetic susceptibility artifacts from dental arches and hardware often compromise MRI neurography of jaw and facial nerves. This study aims to characterize these artifacts and provide insigh...

Spatial Dosimetric-Based Prediction of Long-Term Urinary Toxicity after Permanent Prostate Brachytherapy

Authors: Rajeev K. Badkul, Ronald C Chen, Ying Hou, Harold Li, Chaoqiong Ma, Jufri Setianegara

Affiliation: Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose:
Postimplant urinary toxicity is common in prostate low-dose-rate (LDR) brachytherapy. We developed a machine learning (ML) model to explore the correlation between spatial dose distributio...

Spot Map Modification for Planning Optimization on a Spot Scanning Proton System with Adaptive Aperture

Authors: Austen N. Curcuru, Winter Green, Yao Hao, Jiayi Liu, Yuting Peng, Tiezhi Zhang, Xiandong Zhao

Affiliation: Washington University School of Medicine, Department of Radiation Oncology, WashU Medicine, Virginia Commonwealth University, Washington University School of Medicine, Washington University in St. Louis

Abstract Preview: Purpose: We proposed a treatment planning optimization method that utilizes customized spot map modification to achieve less dosimetry uncertainty, monitor unit ratio (MUR) and neutron dose in a spot ...

Synthetic Vs. Conventional Planar Imaging: Performance and Clinical Feasibility

Authors: Jennifer Kwak, Chelsea Manica, Justin K. Mikell, Michael Silosky, Wendy Siman

Affiliation: Washington University School of Medicine in St. Louis, University of Colorado Anschutz Medical Campus, School of Medicine, Rocky Vista University

Abstract Preview: Purpose:
This study evaluates synthetic planar imaging (synP) from SPECT projections against conventional planar imaging, focusing on detectability, spatial resolution, and feasibility. SynP allows...

Technical Feasibility and Accuracy of Dynamic Longitudinal Couch Motion during Beam Delivery

Authors: Chonthicha Bunchuailuea, David Geeler, Martin Sabel, Claas Wessels

Affiliation: Varian Medical Systems

Abstract Preview: Purpose: Elongated treatment sites, such as craniospinal treatments, pose multiple challenges in today’s practices, requiring multiple CBCTs for position verifications per fraction, which might increa...

The CT Calibration for Proton Pencil Beams System

Authors: Xiangli Cui, Wanli Huo, Jie Li, Lingling Liu, Tao Ma, Yuanyuan Wang

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Ion Medical Center, Hefei Cancer Hospital, Chinese Academy of Sciences, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University

Abstract Preview: Purpose: In practice, treatment planning systems (TPS) of proton therapy require a CT calibration curve, which relates Hounsfield units (HU) to relative stopping power (RSP). Single-energy CT as a sta...

The Feasibility of Ethos-Based Pulsed Reduced Dose-Rate (PRDR) Radiotherapy

Authors: Chia-Lung Chien, Renteng Hou, Wen C. Hsi, Faraz Kalantari, Ganesh Narayanasamy, Zhong Su

Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)

Abstract Preview: Purpose:
PRDR is an effective re-irradiation treatment for patients who have already reached the tolerance dose to their organs at risk (OARs). While PRDR is implemented on TrueBeam by limiting the...

Topas-Nbio – Status and Outlook after a Decade of Developments

Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Kathryn D Held, Nicolas Henthorn, Jay LaVerne, Thongchai Masilela, Stephen J. McMahon, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin, Michael Taylor, John Warmenhoven

Affiliation: Massachusetts General Hospital, Queen's University Belfast, Massachusetts General Hospital and Harvard Medical School, University of California San Francisco, University of Manchester, Notre Dame University

Abstract Preview: Purpose: TOPAS-nBio brings a cutting-edge Monte Carlo (MC) simulation framework to the research community to test hypotheses of radiation effects at the nanometer/cell scale. Here, we present the deve...

Towards Optimal Target Dose Conformity and Dose Drop-Off: Evaluation of a New Optimization Approach for Biology-Guided Radiotherapy Treatment Planning

Authors: Grant Gibbard, Chunhui Han, An Liu

Affiliation: RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: To evaluate the efficacy of a new approach to streamline treatment planning for biology-guided radiotherapy (BgRT) of fluorodeoxyglucose (FDG)-avid bony lesions on a BgRT machine with real-ti...

Towards Penile Small Vessel Imaging with Ferumoxytol-Enhanced MRI

Authors: Darren Fang, Amar Kishan, Justin McWilliams, Dan Ruan, Xiaodong Zhong

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, Department of Radiology, University of California, Los Angeles, Department of Radiological Sciences, University of California, Los Angeles

Abstract Preview: Purpose: Prostate radiotherapy can malform penile vasculature, contributing to erectile dysfunction and compromising quality of life. To detect, quantify, and preferably avoid such occurrences, this p...

Towards Real-Time Marker-Less Prostate Tracking on Standard Radiation Therapy Systems

Authors: Freeman Jin, Paul J. Keall, Alistair MacDonald, Adam Mylonas, Chandrima Sengupta

Affiliation: Image X Institute, Faculty of Medicine and Health, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney, Image X Institute, School of Health Sciences, University of Sydney

Abstract Preview: Purpose: During radiation therapy, tumours in the prostate may move from the planned treatment position, leading to significant dose deviations above clinical tolerances Surveys have indicated the nee...

Two Radiochemical Monte Carlo Models to Investigate the Radical Yields Under Proton Flash Irradiations

Authors: Yujie Chi, Yao Hao, Xun Jia, Youfang Lai, Yuting Peng, Francisco Javier Reynoso, Lingshu Yin, Tianyu Zhao, Xiandong Zhao

Affiliation: Johns Hopkins University, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Physics, University of Texas at Arlington, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, University of South Florida

Abstract Preview: Purpose: FLASH radiation therapy has shown remarkable tissue sparing effects compared to radiation therapy at conventional dose rates (CDR). Yet, its mechanism remains unclear. Radical production modu...

Ultra-Fast Commissioning and Quality Assurance with Plastic Scintillation Detector

Authors: Saad Bin Saeed Ahmed, Marcos Feijoo, Wazir Muhammad, Charles Shang, Naseem Ud Din

Affiliation: South Florida Proton Therapy Institute, Miami Cancer Institute, Blue Physics LLC, Florida Atlantic University

Abstract Preview: Purpose: Accurate, efficient, and reliable commissioning of linear accelerator (LINAC) is critical for ensuring high-quality radiation therapy treatments. The study uses advanced detector technology a...

Ultra-Sparse-View Cone-Beam CT Reconstruction Based Strictly-Structure-Preserved Deep Neural Network in Image-Guided Radiation Therapy

Authors: Guangjun Li, Ying Song, Huanan Tang, Tianxiong Wu, Qiuyi Ye, Wei Zhang

Affiliation: West China Second Hospital of Sichuan University, United Imaging Healthcare, West China Hospital of Sichuan University

Abstract Preview: Purpose:
To propose a general low-dose reconstruction model for ultra-sparse-view cone-beam CT (CBCT) and evaluate its clinical application in improving image quality and reducing radiation dose fo...

Universal Anatomical Mapping and Patient-Specific Prior Implicit Neural Representation for MRI Super-Resolution

Authors: Jie Deng, Yunxiang Li, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Magnetic Resonance Imaging (MRI) has exceptional soft tissue contrast and an essential role in radiotherapy. The introduction of clinical MR-LINACs has enabled adaptive radiotherapy (ART) usi...

Unlocking Adaptive Radiotherapy Flexibility: Integrating Ethos Adaptive Therapy and Halcyon IGRT with Scripting Innovations

Authors: Min Geon Choi, Sean J. Domal, Ruiqi Li, Taoran Li, Mu-Han Lin, Yang Kyun Park, David D.M. Parsons, Justin D. Visak

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, University of Pennsylvania, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Ethos X-ray-guided online adaptive radiotherapy (ART) enables precise, daily adaptive treatments but requires significant resources, limiting widespread adoption. Many treatment sites do not ...

Using Multiple Sequences MRI for Synthesizing CT Based on a Deep Learning Approach

Authors: Jie Hu, Nan Li, Chuanbin Xie, Shouping Xu, Xinlei Xu, Gaolong Zhang, Zhilei Zhang

Affiliation: School of Physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Radiation Oncology, the First Medical Center of the People's Liberation Army General Hospital, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, Peopleʼs Republic of China, Department of Radiation Oncology, School of Physics, Beihang University, Beijing, 102206, Peopleʼs Republic of China

Abstract Preview: Purpose: This study aims to synthesize CT images for MRI-only radiation therapy using a deep learning approach that integrates information from the T1- and T2-weighted MRI sequence.
Methods: 97 hea...

Utilization of Log File Analysis to Determine Deliverability of VMAT Plans As a Function of Plan Complexity

Authors: Jameson T. Baker, Sean T Grace, Cindy Pham, Michael A. Trager

Affiliation: Northwell

Abstract Preview: Purpose:
In VMAT planning, increasing complexity in MLC motion and modulation may improve dose distributions and OAR sparing while maintaining PTV coverage. However, increasing complexity can creat...

Validation of SRS Mapcheck for Patient-Specific Quality Assurance of Cyberknife

Authors: Dong Wook Kim, Hojae Kim, Hojin Kim, Jin Sung Kim, Tae Ho Kim, Sangmin Lee

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine

Abstract Preview: Purpose: The CyberKnife system, designed for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT), considers SRS MapCHECK an effective tool for patient-specific QA (PSQA). This wo...

Visualization of Irradiation Field in Carbon-Ion Therapy By Openpet: Preliminary Analysis of Clinical Data

Authors: Go Akamatsu, Hiroaki Ikawa, Yuma Iwao, Han Gyu Kang, Masashi Koto, Hideyuki Mizuno, Akram Mohammadi, Makoto Shinoto, Minoru Tajiri, Hideaki Tashima, Chie Toramatsu, Taiga Yamaya

Affiliation: National Institutes for Quantum Science and Technology

Abstract Preview: Purpose: In-beam positron emission tomography (PET), in which positron emitters produced through fragmentation reactions are visualized, is a practical method for range verification in particle therap...

Weak-to-Strong Generalization for Interpretable Deep Learning-Based Histological Image Classification Guided By Hand-Crafted Features

Authors: Mark Anastasio, Zong Fan, Hua Li, Changjie Lu, Lulu Sun, Xiaowei Wang, Zhimin Wang, Michael Wu

Affiliation: University of Illinois at Urbana-Champaign, University of Illinois at Chicago, Washington University School of Medicine, University of Illinois Urbana-Champaign, Washington University in St. Louis, University Laboratory High School

Abstract Preview: Purpose: Histological whole slide images (WSIs) are vital in clinical diagnosis. Although deep learning (DL) methods have achieved great success in this task, they often lack interpretability. Traditi...

Weekly Changes in Ventilation Response for Photon and Proton Patients during Radiotherapy

Authors: Kristy K. Brock, Austin Castelo, Yulun He, Zhongxing Liao, Rebecca Lim, Radhe Mohan, Caleb O'Connor, Tien T Tang, Uwe Titt

Affiliation: University of Washington, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Conformal dose distributions in proton radiotherapy promise to reduce normal tissue toxicity such as radiation-induced pneumonitis, but this has not been fully realized in clinical trials. To...

ā€œSeeā€ through Surface: Transforming Surface Imaging into a Real-Time Three-Dimensional Imaging Solution for Intra-Treatment Image Guidance

Authors: Steve B. Jiang, Ruiqi Li, Hua-Chieh Shao, Kenneth Westover, You Zhang, Tingliang Zhuang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Respiratory motion is a long-standing challenge for lung SBRT, particularly for centrally-located lung tumors where increased toxicity demands more precise motion management during treatme...