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Results for "Sean D. Rose": 239 found

3D Bioprinted Brain Cancer Constructs for Experimental Synchrotron Radiotherapy

Authors: John Paul Ortiz Bustillo, Elette Engels, Elrick T. Inocencio, Michael Lerch, Julia Rebecca D Posadas, Anatoly Rosenfeld, Kiarn Roughley, Moeava Tehei, Gordon Wallace, Danielle Warren, Vincent de Rover

Affiliation: Centre for Medical Radiation Physics, University of Wollongong Australia, Department of Radiology, University of the Philippines- Philippine General Hospital, Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong Australia, Centre for Medical Radiation Physics, University of Wollongong, Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, University of the Philippines Manila; Centre for Medical Radiation Physics, University of Wollongong Australia

Abstract Preview: Purpose: To compare the biological response through cell viability assay and fluorescence imaging of 3D bioprinted brain cancer (glioma) constructs relative to 2D monolayer and 3D spheroid culture for...

3D Image Quality Evaluation of a New CT Scanner Employing 3D Landmark Scans, Super Resolution Reconstruction, and Ag Beam Filtration

Authors: Ishika Bhaumik, John M. Boone, Michael T Corwin, Eric S Diaz, Ahmadreza Ghasemiesfe, Andrew M. Hernandez, Sarah E. McKenney, Misagh Piran, Ali Uneri, Eric L White

Affiliation: UC Davis, UC Davis Health, University of California, Johns Hopkins Univ

Abstract Preview: Purpose: A new model CT scanner (Canon Aquilion One Insight) was recently installed at our institution, and it included a 3D Landmark (3DLM) scan for automatic scan planning, a new deep learning recon...

A Comparative Analysis of the Dosimetric, Alignment, and Setup Efficiency in Left Breast Cancer Radiotherapy Treated with Dibh Using ABC and Sgrt

Authors: Aaron Conard, Victoria Croog, Marie Gurka, Lan Lin

Affiliation: Johns Hopkins University

Abstract Preview: Purpose:
This study evaluates the utility of the Active Breathing Coordinator (ABC) and Surface Guided Radiation Therapy (SGRT) techniques in implementing Deep Inspiration Breath Hold (DIBH) for le...

A Comparison of the Impact to Mean Doses to Organs at Risk of Small Versus Large Spot Sizes in Pelvic Proton Therapy

Authors: Jamie s Baker, Sam Beddar, Mahsa Dehghanpour, Ariel MT Hoang, Emma Holliday, Rachael M. Martin Paulpeter, Joshua S. Niedzielski, Luis Augusto Perles, Josie S Ruzek, Gabriel O. Sawakuchi

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, niversity of Texas MD Anderson Cancer Center School of Health Professions, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, University of Texas MD Anderson Cancer Center School of Health Professions

Abstract Preview: Purpose: This study aims to evaluate the dosimetric impact on organs at risk (OAR) of small versus large spot sizes when treating pelvic cancer patients with pencil beam scanning (PBS) proton therapy....

A Deep Learning Approach to the Prediction of Gamma Passing Rates in VMAT Radiotherapy Plans for Adaptive Treatment.

Authors: Jenghwa Chang, Kuan Huang, Lyu Huang, Jason Lima, Jian Liu, Farzin Motamedi

Affiliation: Northwell, Department of Computer Science and Technology, Kean University, Physics and Astronomy, Hofstra University, Hofstra University Medical Physics Program

Abstract Preview: Title: A Deep Learning Approach to the Prediction of Gamma Passing Rates in VMAT Radiotherapy Plans for Adaptive Treatment.
Purpose: This study aims to develop a deep learning algorithm to predict ...

A Deep Learning-Based Method for Rapid Generation of Spot Weights in Single Field Optimization for Proton Therapy in Prostate Cancer

Authors: Yu Chang, Mei Chen

Affiliation: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Abstract Preview: Purpose: Spot weights optimization, as a critical step in the proton therapy, is often time-consuming and labor-intensive. Deep learning, with its powerful learning and computational efficiency, can e...

A Framework for Automated Selection of Dose-Volume Objectives to Improve Radiation-Induced Immune Suppression (RIIS)-Related Overall Survival (OS) Following Chemo-Radiotherapy

Authors: Gabriel Lucas Andrade de Sousa, Einsley-Marie Janowski, Cam Nguyen, Krishni Wijesooriya

Affiliation: Department of Radiation Oncology, University of Virginia, Department of Physics, University of Virginia

Abstract Preview: Purpose: Optimizing radiation therapy (RT) to spare the immune system may improve Overall Survival (OS) in cancer patients. This study develops a computational algorithm to identify optimal dose-volum...

A Ground Truth Label-Mediated Method for Improved Bone and Gas Cavity Definition for MRI-Guided Online Adaptive Radiotherapy Workflows Using Synthetic CT Images.

Authors: Benito De Celis Alonso, Braian Adair Maldonado Luna, Gerardo Uriel Perez Rojas, René Eduardo Rodríguez-Pérez, Kamal Singhrao

Affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Faculty of Physics and Mathematics, Benemérita Universidad Autónoma de Puebla

Abstract Preview: Purpose: Artificial Intelligence (AI)-generated synthetic CT (sCT) images can be used to provide electron densities for dose calculation for online adaptive MRI-guided stereotactic body radiotherapy (...

A Hybrid Population-Based and Patient-Specific Framework for 2D–3D Deformable Registration-Driven Limited-Angle Cone-Beam CT Estimation

Authors: Xiaoxue Qian, Hua-Chieh Shao, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Limited-angle CBCT (LA-CBCT) reduces imaging time and dose but suffers from under-sampling artifacts. 2D–3D deformable registration addresses this problem by estimating LA-CBCTs from defor...

A Method to Check the Consistency and Reproducibility of VMAT Delivery

Authors: Chloe Doen Kim, Patricia E. Lindsay, Bern Norrlinger, Jan P. Seuntjens

Affiliation: Princess Margaret Cancer Centre & University of Toronto, Queen's University, Princess Margaret Cancer Centre

Abstract Preview: Purpose: To propose a method to check the consistency of VMAT delivery on linear accelerator (LINAC) with a commercial three-dimensional array device. The method is insensitive to the correction facto...

A Multi-Omics Approach for Predicting Acute Hematologic Toxicity in Patients with Cervical Cancer Undergoing External-Beam Radiotherapy

Authors: Sijuan Huang, Yongbao Li

Affiliation: Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, 510060, China, Sun-Yat sen University Cancer Center

Abstract Preview: Purpose: Hematologic toxicity (HT) is one of the most prevalent treatment-related toxicities experienced by locally advanced cervical cancer (LACC) patients receiving radiotherapy (RT). This study aim...

A New Voxel-Based Similarity Approach for Assessing Contour Similarity and Clinical Dosimetric Effect

Authors: Shari Damast, Svetlana Kuznetsova, Christopher J. Tien

Affiliation: Yale University School of Medicine, Department of Therapeutic Radiology, Yale University School of Medicine

Abstract Preview: Purpose: Current contour similarity evaluation approaches (Dice Similarity Coefficient, Mean Distance to Agreement) are limited to geometric agreement without assessment of ultimate dosimetric impact....

A Novel 2D Scintillation Dosimeter Using Long Scintillating Fibers.

Authors: Louis Archambault, Luc Beaulieu, Alexis Horik, Sajjad Ahmad Khan

Affiliation: Département de Physique, de Génie Physique et D'optique, et Centre de Recherche sur le Cancer, Université Laval, Département de physique, de génie physique et d'optique, Université Laval

Abstract Preview: Purpose: This study presents a novel 2D scintillation dosimeter leveraging long scintillating fibers for quality assurance (QA) in radiotherapy. The primary goal is to optimize critical parameters suc...

A Novel Cost-Effective Customizable 3D-Printed Thoracic Phantom for End-to-End Treatment Verification and Image Quality Assessment

Authors: Reza Farjam, Russell K Hales, Seth Jayawardane, Todd R. McNutt, Mohammad Rezaee, Ehsan Tajikmansoury, K. Ranh Voong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University, Department of Biomedical Engineering, Johns Hopkins School of Medicine

Abstract Preview: Purpose: This study presents a novel cost-effective customizable 3D-printed phantom developed for end-to-end treatment verification and image-quality assessment for thoracic applications.
Methods: ...

A Novel Lattice Technique Based Spot Scanning Proton Arc Therapy Via Spot Sparsity Optimization and LET Optimization

Authors: Zhitao Dai, Riao Dao, Xuanfeng Ding, Qingkun Fan, Yajun Jia, Gang Liu, Gang Peng, Yujia Qian, Hong Quan, Kunyu Yang, Sheng Zhang, Lewei Zhao

Affiliation: Department of Radiation Oncology, Stanford University, Corewellhealth William Beaumont University Hospital, School of Mathematics and Statistics, Wuhan University, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Chinese Academy of Medical Sciences Cancer Hospital Shenzhen Hospital, School of Physics and Technology,Wuhan University, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose: Lattice radiation therapy (LRT) is an innovative three-dimensional(3D) implementation type of spatially fractionated radiation therapy (SFRT). This study aims to develop a novel spot-scanning...

A Python Package for GPU-Accelerated Photon Dose Calculation for Advanced and Generalizable Auto-Planning Approaches: Validation for Multiple Linear Accelerator Vendors and Institutions

Authors: Jaryd Ricardo Christie, Anthony J. Doemer, William T. Hrinivich, Junghoon Lee, Calin Reamy, Kundan S Thind

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University, Henry Ford Health

Abstract Preview: Purpose: To develop and validate an open-source Python package for fast, widely compatible, and user-friendly photon dose calculation algorithm through comparisons with clinical treatment planning sys...

A Quantitative Analysis of Interplay Effects in IMPT for Lung Cancer SBRT: Comparing Two Machine Delivery Sequence Models

Authors: Xiaoda Cong, Xuanfeng Ding, Gang Liu, Peilin Liu, Lewei Zhao

Affiliation: Department of Radiation Oncology, Stanford University, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Corewellhealth William Beaumont University Hospital

Abstract Preview: Purpose: This study quantitatively evaluates the interplay effect in intensity-modulated proton therapy (IMPT) for lung cancer stereotactic body radiotherapy (SBRT) using two different machine deliver...

A Real-Time 6 Degrees-of-Freedom Image Guided Radiation Therapy Technology Using Internal-External Motion Correlation Modelling

Authors: Jeremy T. Booth, Nicholas Hardcastle, Freeman Jin, Alicja Kaczynska, Paul J. Keall, Chandrima Sengupta

Affiliation: Northern Sydney Cancer Centre, Royal North Shore Hospital, Physical Sciences, Peter MacCallum Cancer Centre, Image X Institute, Faculty of Medicine and Health, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney

Abstract Preview: Purpose: An ESTRO survey reported that 71% of radiotherapy centers across 41 countries want to implement real-time image guided radiation therapy (IGRT) to improve patient outcomes. To address this gl...

A Surface-Conforming Flexible Collimator for Improving Electron Radiotherapy

Authors: Neil A. Kirby, Parker New, Niko Papanikolaou, Holly Paschal, Karl H. Rasmussen, Daniel L. Saenz

Affiliation: UT Health San Antonio

Abstract Preview: Purpose: To simplify the traditional method of patient-specific skin collimation and improve the precision of electron radiotherapy treatment with a new surface conforming collimation system.
Metho...

A Tool to Quantitatively Assess Dose after Patient Motion

Authors: Asma Amjad, Renae Conlin, Beth A. Erickson, William Hall, Eric S. Paulson, Christina M. Sarosiek

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: The adapt-to-shape (ATS) workflow on the MR-Linac involves manual contour edits followed by treatment plan reoptimization on daily pre-beam MRIs. A verification image is acquired after plan o...

A Two-Layer, Two-Task Prediction Model Based on 3D Imaging and Residual Networks for Mid-Chemoradiation Tumor Response Prediction on FDG PET for La-NSCLC

Authors: Stephen R. Bowen, Chunyan Duan, Daniel S. Hippe, Qiantuo Liu, Jing Sun, Jiajie Wang, Shouyi Wang, Faisal Yaseen, Xiaojing Zhu

Affiliation: Tongji University, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Shanghai University of Electric Power, Fred Hutchinson Cancer Center, University of Texas at Arlington

Abstract Preview: Purpose: Accurate prediction of patient response to radiotherapy plays a crucial role in monitoring disease progression and assessing treatment efficacy, enabling clinicians to develop personalized th...

A Vqvae-Based Framework with Embedded Kullback-Leibler Divergence for Stochastic and Diverse Dose Prediction

Authors: Weigang Hu

Affiliation: Fudan University Shanghai Cancer Center

Abstract Preview: Purpose: The purpose of this study is to introduce a VQVAE-based framework that addresses the limitations of conventional dose prediction methods, which rely on fixed deep learning models that produce...

AI Auto-Contouring for CT-Based High-Dose-Rate Interstitial Brachytherapy of Cervical Cancer: Implications for Organ-at-Risk (OAR) Contouring and Dosimetric Analysis

Authors: Indrin J. Chetty, Jing Cui, Mitchell Kamrava, Tiffany M. Phillips, Jennifer M. Steers, Brad Stiehl

Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center

Abstract Preview: Purpose: Auto-contouring for HDR interstitial brachytherapy can be confounded by large deformation in anatomy and image quality. Here we evaluated the performance of an AI-based auto-contouring softwa...

AI-Assisted Algorithm to Generate Patient Postures for Tset Dose Evaluation

Authors: Kostas Danniidis, Agelos Kratimenos, Yufu Wang, Timothy C. Zhu, Yifeng Zhu

Affiliation: University of Pennsylvania

Abstract Preview: Purpose: This study aims to develop software and algorithms utilizing artificial intelligence (AI) to seamlessly create 3D patient postures during Total Skin Electron Therapy (TSET). The resulting mes...

Adaptive Proton Flash Therapy through Iterative Modular Pin Recycling

Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou

Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose:
We propose a method to optimize adaptive proton FLASH therapy (ADP-FLASH) using modularized pin-ridge filters (pRFs) by recycling module pins from the initial plan, reducing pRF adjustment...

Advancing Deep Segmentation Accuracy in CBCT for Radiotherapy Via Robust Scatter Mitigation: First Results from a Pilot Trial

Authors: Cem Altunbas, Farhang Bayat, Roy Bliley, Rupesh Dotel, Brian Kavanagh, Uttam Pyakurel, Tyler Robin, Ryan Sabounchi

Affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Taussig Cancer Center, Cleveland Clinic, University of Colorado Anschutz Medical Campus

Abstract Preview: Purpose: Automatic segmentation of anatomical structures in CBCT images is key to enabling dose delivery monitoring and online plan modifications in radiotherapy. However, poor image quality can degra...

Advancing Ionizing Radiation Acoustic Imaging: A Deep Learning Approach for Denoising and Quantitative Reconstruction

Authors: Kyle Cuneo, Issam M. El Naqa, Dale W. Litzenberg, Yiming Liu, Xueding Wang, Lise Wei, Wei Zhang, Jiaren Zou

Affiliation: University of Michigan, H. Lee Moffitt Cancer Center

Abstract Preview: Purpose: To quantitatively map 3D dose deposition during radiotherapy, empowering real-time adaptive radiation treatment.

Methods: The research features reconstructing dose deposition from acou...

Advancing Thoracic Synthetic CT Images with Enhanced Cyclegan for Adaptive Radiotherapy Applications

Authors: Silambarasan Anbumani, Nicolette O'Connell, Eenas A. Omari, Amanda Pan, Eric S. Paulson, Lindsay Puckett, Monica E. Shukla, Dan Thill, Jiaofeng Xu

Affiliation: Elekta Inc, Elekta Limited, Linac House, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Accurate electron density information from on-board imaging is essential for direct dose calculations in adaptive radiotherapy (ART). This study evaluates a deep learning model for thoracic s...

An Analytical Framework to Quantify the Effect Obstructing Anatomical Features in Intrafractional Spectral Imaging Using a Dual-Layer Kv Imager

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Marios Myronakis

Affiliation: Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory

Abstract Preview: Purpose:
Dual-layer kV imager (DLI) architecture enables the capability for single-shot dual-energy (DE) intrafraction imaging. As noise from individual DLI layers are primarily uncorrelated, simpl...

An End-to-End Test for Adaptive Radiotherapy with Varian Hypersight CBCT Imaging System Using Radiochromic Film in a Rando Pelvis Phantom

Authors: Jameson T. Baker, Yijian Cao, Jenghwa Chang, Sean T Grace, Lyu Huang, Jian Liu, Echezona Simon Obi, Anurag Sharma

Affiliation: Northwell, Hofstra University Medical Physics Program

Abstract Preview: Purpose:
To validate the end-to-end dosimetrical accuracy of Varian HyperSight CBCT for adaptive radiotherapy (ART), from simulation to dose delivery, using radiochromic film dosimetry in a Rando p...

An Integrated Robust Inverse Planning Based on AI-Built Dose Kernel Library for Preclinical Radio-Neuromodulation Using Focused Kv X-Rays

Authors: Wenbo Gu, Chenhui Qiu, Ke Sheng, Liyan Sun, Weiyuan Sun, Lei Xing

Affiliation: Department of Radiation Oncology, Stanford University, Department of Radiology, Stanford University, University of Pennsylvania, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, Stanford University,

Abstract Preview: Purpose:
The small animal radio-neuromodulation platform developed in our previous work utilized focused kV x-ray beams rotating and translating in predefined trajectories to irradiate small, mm si...

An OAR Margin Recipe Based on Clinical Data and Including Radio-Sensitivity Variation

Authors: Carlo Greco, Joep Stroom, Sandra Vieira

Affiliation: Champalimaud Center for the Unknown

Abstract Preview: Purpose: RTP safety margins are generally based on geometrical uncertainties alone and not directly on clinical outcome. Here we use clinical dose-constraint data to generate dosimetric margins for OA...

Application and Analysis of Advanced 3D Printed Materials As Bolus for Radiation Therapy

Authors: Rami M. Shorti, Gary R. Stinnett

Affiliation: Intermountain Health, Radiation Oncology, Intermountain Health, Advanced Visualization Engineering Department

Abstract Preview: Purpose: In this work we present the workflow, materials analysis, and lessons learned from leveraging advanced 3D printing Polyjet Technology to print conformal bolus for radiation therapy.
Method...

Application of the Lymphodose Framework to Brain Tumors: Unveiling the Prognostic Power of Circulating Lymphocyte Doses

Authors: Sophie Bockel, Eric Deutsch, Frederic Dhermain, Ibrahima Diallo, Anh Thu Le, Elaine Limkin, Pauline Maury, Charlotte Robert, Killian Sambourg, Camilla Satragno, Cristina Veres, François de Kermenguy

Affiliation: Gustave Roussy, Département de radiothérapie, Université Paris-Saclay, Gustave Roussy, Inserm U1030, Radiothérapie Moléculaire et Innovation Thérapeutique

Abstract Preview: Purpose:
To study the correlation between the dose to circulating lymphocytes as evaluated by the LymphoDose framework and the incidence of severe radiation-induced lymphopenia (sRIL) in patients t...

Assessing Dose Enhancement and Shadowing Effects in Head and Neck Cases with Titanium Mandibular Implants

Authors: Sarah A. Ashmeg, Travis James McCaw, Joseph Shields, Matthew Spector, Christopher Tyerech, Christopher T Wilke

Affiliation: UPMC Hillman Cancer Center, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, UPMC Hillman Cancer Center, Department of Radiation Oncology, University of Pennsylvania, UPMC

Abstract Preview: Purpose: Patients with oral cavity cancer often undergo surgical extirpation prior to radiation, and surgical implants are utilized to reconstruct the resulting defect. This study dosimetrically evalu...

Assessing Skin Microcirculation in Breast Cancer Radiotherapy: Effectiveness of a Specialized Bra Compared in Two Hypofractionated Protocols.

Authors: Rosa Maria CibriĂĄn Ortiz de Anda, Altea C Esteve, Carlos M Galindo-GonzĂĄlez, Carmen C GarcĂ­a, Amparo Gonzalez-Sanchis, Jose C Gordo-Partearroyo, Emilio Soria-Olivas, Javier Vijande

Affiliation: IFIC-UV, Valencia University, Hospital General Universitario

Abstract Preview: Purpose: To determine how skin microcirculation is affected by the two hypo-fractionated radiotherapy protocols in breast cancer patients using Laser Doppler Imaging, a non-invasive method for assessi...

Assessing the Feasibility of LD-V1 Film for Annual Kilovoltage Imaging Dose Measurements

Authors: Maria F. Chan, Seng Boh Gary Lim, Shih-Chi Lin, Dustin W. Lynch, Usman Mahmood, Jeonghoon Park

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To explore the feasibility of using GafChromic LD-V1 film for annual imaging dose assessment across kV radiography, fluoroscopy, and cone beam computed tomography (CBCT) imaging protocols, as...

Assessing the Impact of Intrafraction Shifts on Critical OAR Doses in a Standardized Spine SBRT Program

Authors: Daniel A. Alexander, Anish Butala, Anthony Austin Kassaee, Neil Malhotra, Ian Messing, Gabrielle W Peters, Ryan M. Scheuermann

Affiliation: Department of Radiation Oncology and Applied Sciences, University of Pennsylvania

Abstract Preview: Purpose: Stereotactic Body Radiation Therapy (SBRT) for spinal metastases uses CBCT-based localization and highly conformal treatment delivery to increase the biologically equivalent dose to the targe...

Assessing the Potential of Virtual Grid Portable Radiographic Systems for Radiation Dose Reduction: A Comparative Evaluation of Deviation Index in Abdominal Imaging

Authors: Gary Y. Ge, Azmul Siddique, Jie Zhang

Affiliation: Department of Radiology, University of Kentucky, University of Kentucky

Abstract Preview: Purpose: Virtual grid technology addresses scattered radiation without a physical grid, offering the potential to reduce patient radiation dose while maintaining image quality. However, this potential...

Assessment of Image Quality and Dose in Dual-Energy X-Ray Imaging for Lung Tumor Tracking

Authors: Nawal Alqethami, Felix Ginzinger, Prasannakumar Palaniappan, Marco Riboldi, Philipp Steininger, Wentao Xie

Affiliation: Research & Development, medPhoton GmbH, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t MĂŒnchen (LMU Munich)

Abstract Preview: Purpose:
This study evaluates the image quality of Dual-Energy (DE) X-ray imaging for lung tumor tracking across various sizes and protocols, comparing its imaging dose to Single-Energy (SE) imagin...

Assessment of the Radiological Features of 3D-Printed Polylactic Acid Composites for Creating Personalized Dosimetric Phantoms

Authors: Ashish Binjola, Raj Kishore Bisht, Natanasabapathi Gopishankar, Pratik Kumar, Daya Nand Kishore Sharma, Sukhvir Kishore Singh, Subramani Vellaiyan

Affiliation: Medical Physics Unit, All India Institute of Medical Sciences, All India Institute of Medical Sciences, Department of Radiological Safety, Institute of Nuclear Medicine and Allied Sciences, Department of Radiation Oncology, All India Institute of Medical Sciences

Abstract Preview: Purpose: Additive manufacturing is increasingly being explored to create dosimetry phantoms. Commercial anthropomorphic phantoms represent an average patient and lack anatomical variations due to obes...

Automated MR Segmentation for Online Adaptive MR-Linac Therapy Using an in-House Model

Authors: David L. Barbee, David Byun, Matt Long, Jose R. Teruel Antolin, Michael J Zelefsky

Affiliation: NYU Langone Health

Abstract Preview: Purpose:
Online adaptive MR-Linac therapy requires contour adaptation, often adding 20 minutes to treatment time and reducing machine throughput. This study introduces a fully automated MR contour ...

Automated Review of Radiation Treatment Delivery Reports Using Openai

Authors: Ramesh Boggula, Nikhil Jordan Shad

Affiliation: Wayne State University

Abstract Preview: Purpose: To evaluate the effectiveness of OpenAI in reviewing large volumes of radiation delivery reports from Mobius3D/FX. The goal was to assess whether automating this process could identify potent...

Automatic Contour Quality Assurance Using Deep-Learning Based Contours

Authors: Laurence Edward Court, Raphael Douglas, David Fuentes, Anuja Jhingran, Barbara Marquez, Raymond Mumme, Christine Peterson, Julianne M. Pollard-Larkin, Surendra Prajapati, Dong Joo Rhee, Thomas J. Whitaker

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Safe deployment of auto-contouring models requires the inclusion of automated quality assurance (QA). One approach is to use an independent auto-contouring model and compare the contours geom...

Automatic Specific Absorption Rate (SAR) Prediction for Hyperthermia Treatment Planning (HTP) Using Deep Learning Method

Authors: Yankun Lang, Lei Ren, Dario B. Rodrigues

Affiliation: University of Maryland School of Medicine, Department of Radiation Oncology, University of Maryland School of Medicine

Abstract Preview: Purpose:
HTP of microwave (MW) phased-array systems determine MW antenna settings to maximize energy absorption (SAR in W/kg) in tumor. Conventional HTP algorithms calculate SAR based on electromag...

Automation of Clinical Protocol Imports for Treatment Planning System Version Update Compatibility

Authors: Michael Ashenafi, Mario Ramos Gallardo, Amy Herman, Sean M. Tanny

Affiliation: Department of Radiation Oncology, University of Rochester

Abstract Preview: Purpose: Updates to the Varian Eclipse Treatment Planning System (TPS) have introduced new objects to replace pre-existing Clinical Protocols to aide clinicians in plan quality assessment. We have cre...

BEST IN PHYSICS IMAGING: Dosimetric Impact of Iodinated Contrast Agent on Fibroglandular Tissue in Contrast-Enhanced Digital Mammography

Authors: Hannah Grover, Andrew J. Sampson

Affiliation: Oregon Health & Science University, UT Health San Antonio

Abstract Preview: Purpose: The goal of this work was to quantify the dosimetric impact of iodinated contrast on fibroglandular breast tissue to better inform clinical risk and benefit assessments when determining the m...

BEST IN PHYSICS IMAGING: Volumetric Sampling Properties of Longitudinal Multiple X-Ray-Source Array Computed Tomography (MXA-CT)

Authors: Craig K Abbey, John M. Boone, Richard E. Colbeth, Andrew M. Hernandez, Vance Robinson, Paul Schwoebel, Jeffrey H. Siewerdsen, Alejandro Sisniega, Wojciech B. Zbijewski, Huanyi Zhou

Affiliation: UC Santa Barbara, University of California, UT MD Anderson Cancer Center, Johns Hopkins University, University of New Mexico Albuquerque, UC Davis Health, Varex Imaging Corporation

Abstract Preview: Purpose: A new CT configuration utilizing a multiple X-ray-source array (MXA) is under development to mitigate cone-beam (CB) artifacts in single-rotation wide coverage imaging. We investigate the sam...

BEST IN PHYSICS RADIOPHARMACEUTICALS, THERANOSTICS AND NUCLEAR MEDICINE: The Development and Validation of an in-Vitro Alpha Irradiation Platform with Versatile Radiation Control

Authors: Md Mainul Abrar, Harsh Arya, Yujie Chi, Yijing Liu, Joshua Rajan, Pan Zui

Affiliation: University of Texas at Arlington, The University of Texas at Arlington, Department of Physics, University of Texas at Arlington

Abstract Preview: Purpose: Understanding the biological effects of alpha radiation at varying dose rates and energies is essential for advancing therapeutic strategies. This study demonstrates the capabilities of an in...

Beyond Correlation: An Ultra-Large Physics-Driven Vascularized Tumor Model to Bridge Feature Formation with Underlying Biology

Authors: Jiayi Du, Lihua Jin, Ke Sheng, Yu Zhou

Affiliation: Harvard University, University of California, San Francisco, UCLA, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Radiomics enables powerful insights into tumor biology through non-invasive imaging, excelling in diagnostic and prognostic predictions. However, due to a lack of mechanistic connections, que...

Brain Structural Covariance Networks in Nicotine-Dependent Users: A Graph Analysis

Authors: Humberto Monsivais, Brian A. Taylor, Francesco Versace

Affiliation: Purdue University, Department of Behavioral Science, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: To identify possible signatures of altered brain morphometry in nicotine-dependency via a structural covariance network approach.

Methods: Fifty-one healthy controls (HC:27M, mean age=...

Bridging the Gap of Radiotherapy Planning Quality between a High-Income Countrie to a Middle-Income Country By the Dosimetric Validation of a KBP Model Vs Junior, Senior Dosimetrists and MCO Planning

Authors: Eduardo Florian, Hiram Gay, Geoffrey D. Hugo, Otto Hurtarte, Milton Ixquiac, Erick Orlando Montenegro, Franky Eduardo Reyes, Francisco Javier Reynoso, Edgar Aparicio Ruiz, Baozhou Sun, Jacaranda Van Rheenen, Kevin Vega, Angel Velarde, Vicky de Falla

Affiliation: WashU Medicine, Liga Nacional Contra el Cancer, Liga Nacional Contra el Cancer/INCAN, Liga Nacional Contra el Cancer / INCAN, Liga Nacional Contra el Cancer and Universidad de San Carlos de Guatemala, Washington Univ. in St. Louis, Liga Nacional Contra el CĂĄncer / INCAN, Washington University in St. Louis, Varian, Baylor College of Medicine

Abstract Preview: Purpose:
IMRT has become the standard of care in high-income countries (HICs) due to reduced toxicity and improved treatment outcomes.
The purpose of this work is validating the KBP model shared...

CBCT-Based Synthetic CT Imaging for Proton and Photon Dose Monitoring and Adaption in Supine Breast Radiotherapy

Authors: Mark E Artz, Julie Bradley, Hardev Singh Grewal, Perry B. Johnson, Christina Klassen, Raymond Mailhot Vega, Nancy Mendenhall, Jiyeon Park, Emma V. Viviers, Yawei Zhang

Affiliation: UF Health Proton Therapy Institute, University of Florida

Abstract Preview: Purpose: Verification CTs (VFCT) are used in radiotherapy to assess patient dose during treatment. However, they are time-consuming and contribute additional radiation exposure to the patient. This st...

CNN-Based Reconstruction for 3D Scintillation Dosimetry of Proton Pencil Beams

Authors: Sam Beddar, Jason Michael Holmes, Daniel G. Robertson, James J. Sohn, Ethan D. Stolen

Affiliation: Department of Radiation Oncology, Mayo Clinic, MD Anderson Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Department of Radiation and Cellular Oncology, University of Chicago

Abstract Preview: Purpose: Camera-based scintillation dosimetry incorporating large volumes have shown promise for fast and comprehensive evaluation of external beam treatment fields. While some efforts have been made ...

Can Contrast Scans of Dual-Layer Detector Spectral CT be Directly Used for Proton Dose Calculations?

Authors: Wen C. Hsi, Pouya Sabouri, Zhong Su

Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)

Abstract Preview: Purpose:
Traditional single-energy CT (SECT) contrast scans cannot be used for proton dose calculations due to significantly higher HU caused by iodine. Dual-layer dual-energy CT (DL-DECT) can dire...

Characterization of HCC Tumor Response in 90Y-Radioembolization Clinical Trial RAPY90D Using Prospective Voxel Dosimetry

Authors: E Courtney Henry, Srinivas Cheenu Kappadath, Armeen Mahvash

Affiliation: UT MD Anderson Cancer Center

Abstract Preview: Purpose:
Characterization of hepatocellular carcinoma (HCC) tumor responses for single-arm single-center prospective 90Y-radioembolization clinical trial (n=40) that used patient-specific voxel-dos...

Clinical Application of Biology-Guided Radiotherapy (BgRT) to Patient Having a Cardiac Implantable Electronic Device (CIED)

Authors: Girish Bal, Thomas I. Banks, Bin Cai, Yesenia Gonzalez, Zohaib Iqbal, Paul M. Medin, Rameshwar Prasad, Chenyang Shen, Robert Timmerman, Yuanyuan Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: Each year more than one million pacemakers and 200k cardioverter-defibrillators are implanted in patients worldwide. The presence of a CIED introduces challenges to the delivery of radiation ...

Comparative Study between Sparse Primary Sampling Grid Scatter Correction and Low-Count Monte Carlo-Based Scatter Reduction with 3-D Richardson-Lucy Denoising

Authors: Alan Rui Li, Qihui Lyu, Dan Ruan, Ke Sheng

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose:
The Sparse Primary Sampling (SPS) grid was shown in a previous computational study to improve image quality by correcting scatter-induced effects and artifacts in Cone-beam Computed Tomogr...

Comparing Planned Vs. Delivered Bladder Dose-Toxicity Associations in Prostate Cancer Radiotherapy: Insights from the Mirage Trial

Authors: Minsong Cao, Amar Kishan, Yi Lao, An Liu, Beth Neilsen, X. Sharon Qi, Kun Qing, Ke Sheng, Michael Steinberg, Luca F Valle, Terence Williams

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, Department of Radiation Oncology, City of Hope Medical Center, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: To investigate the clinical relevance of planned versus delivered doses in toxicity associations utilizing localized assessment of genitourinary (GU) toxicity in bladder subregions among pros...

Comparing SPECT Dose Reconstruction Algorithm Accuracy As a Function of Imaging Parameters

Authors: Srinivas Cheenu Kappadath, Brian Michael Kelley, Benjamin P. Lopez

Affiliation: UT MD Anderson Cancer Center

Abstract Preview: Purpose:
Imaging systems are subject to errors from finite spatial resolution and voxel size. This work demonstrates their effect on dose algorithm {Monte Carlo (MC), dose-volume kernel (DVK), and ...

Comparison of Dose Metrics to Critical Heart Substructures for Different Planning Techniques, and Scan Techniques for Right Sided Breast Irradiation

Authors: Wesley A. Belcher, Aidan Burke, Matthew Green, Taylor Stamey

Affiliation: ECU Health, East Carolina University Brody School of Medicine

Abstract Preview: Purpose: The purpose of this study was to determine the effect of using deep inhalation breath hold (DIBH) vs. free breathing (FB) and intensity-modulated radiation therapy (IMRT) vs. 3D for right-sid...

Comparison of Respiratory Motion between 4D-MR and 4D-CT in Compression Belt Patients

Authors: Morgan Aire, Krystal M. Kirby, Olivia Magneson, David E. Solis, Hamlet Spears

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: This study evaluates the range of motion of abdominal organs using 4D stack-of-stars magnetic resonance (MR) imaging and 4D computed tomography (CT), the current clinical standard. Accurate o...

Comprehensive Assessment of Intra-Fractional and Inter-Fractional Motion in Intensity-Modulated Proton Therapy for Esophageal Cancer

Authors: Tianyuan Dai, Xiaoying Fan, Shuting Wang, Yong Yin

Affiliation: Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: The purpose of this study was to investigate the interplay effect during intra-fractional motion and the effect of the robust optimization parameters for inter-fractional motion in the intens...

Computed Tomography Organ Dose Library Derived from Newly Developed Newborn-Infant-Toddler Computational Phantoms

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Adam Leon Kesner, Cameron B. Kofler, Juan Camilo Ocampo Ramos, Yitian Wang, Stefan Wehmeier

Affiliation: University of Chicago, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: To develop a slice-specific computed tomography (CT) organ dose library using Monte Carlo radiation transport simulations on a newly created set of newborn, infant, and toddler computational ...

Contingency Planning for Left-Sided Breast Radiation Treatment Using Breath-Hold Technique with Different Delivery Methods

Authors: Nrusingh C. Biswal, Sally Cheston, Sung-Woo Lee, Weiguang Yao, Baoshe Zhang

Affiliation: Department of Radiation Oncology, University of Maryland School of Medicine

Abstract Preview: Purpose: The deep inspiration breath-hold (DIBH) technique in left breast radiation reduces doses to critical organs such as the heart, left lung, and left anterior descending artery (LAD). With the a...

Cross-Calibration of CT Number to Electron and Physical Density: Feasibility of Using Diagnostic Scans for Treatment Planning

Authors: Afrouz Ataei, Andrew R. Godley, Mi-Ae Park, Mahbubur Rahman, Liqiang Ren, Chenyang Shen, Gary Xu

Affiliation: Department of Radiology, UT Southwestern Medical Center, UT Southwestern Medical Center, Rush University, Imaging Services, UT Southwestern Medical Center

Abstract Preview: Purpose: Even though many patients undergo diagnostic CT scans prior to treatment, simulation CT scans are commonly required for treatment planning. This study evaluates whether prior diagnostic CT sc...

Cross-Slice Attention for Unsupervised 3D Pelvic CBCT to CT Translation

Authors: Xu Chen, Jun Lian, Yunkui Pang, Pew-Thian Yap

Affiliation: University of North Carolina at Chapel Hill, Huaqiao University

Abstract Preview: Purpose: Unsupervised CBCT-to-CT translation in the pelvic region is essential for accurate radiotherapy delivery and adaptive image-guided interventions. However, current models for cross-modality tr...

Deep Learning Aided Oropharyngeal Cancer Autoplanning

Authors: Mark Bowers, Gabriel Carrizo, Jimmy Caudell, Vladimir Feygelman, Kevin Greco, Christian Hahn, Jihye Koo, Kujtim Latifi, Fredrik Lofman, Jacopo Parvizi, Muqeem Qayyum, Caleb Sawyer

Affiliation: RaySearch Laboratories, Moffitt Cancer Center

Abstract Preview: Purpose: Head and neck (H&N) radiotherapy planning is complex, with multiple competing objectives. We endeavored to improve efficiency of planning by developing a deep learning (DL) model trained to p...

Deep Learning-Based Auto-Segmentation in Cervical High-Dose-Rate Brachytherapy with Clinical Considerations

Authors: Benjamin Haibe-Kains, Ruiyan Ni, Alexandra Rink

Affiliation: Department of Medical Biophysics, University of Toronto, University Health Network

Abstract Preview: Purpose: Accurate auto-segmentation for targets and organs-at-risk (OARs) using deep learning reduces the delineating time in radiotherapy. In high-dose-rate brachytherapy, specific clinical criteria ...

Deep Learning-Based Dose Distribution Prediction for Automation of Treatment Planning

Authors: Yaspal Badyal, Rabten Datsang, Tianjun Ma, William Song

Affiliation: MVision AI, Virginia Commonwealth University

Abstract Preview: Purpose: Deep learning (DL)-based dose distribution predictions for prostate cancer show significant potential for OAR sparing compared to manually optimized treatment plans. We aim to generate clinic...

Deep Learning-Based Metric Vs Global Noise for CT Image Quality Assessment

Authors: Gary Y. Ge, Abdullah-Al-Zubaer Imran, Kazi Ramisa Rifa, Charles Mike Weaver, Jie Zhang

Affiliation: University of Kentucky

Abstract Preview: Purpose: With renewed attention on CT radiation dose management following CMS approval of new dose measures, establishing image quality–based target doses for every protocol has become essential. Whil...

Deep Learning-Based Plan Quality Prediction for Gamma Knife Radiosurgery of Brain Metastases

Authors: Chih-Wei Chang, Runyu Jiang, Mark Korpics, Yuan Shao, Aranee Sivananthan, Zhen Tian, Ralph Weichselbaum, Xiaofeng Yang, Aubrey Zhang, Xiaoman Zhang

Affiliation: Department of Radiation & Cellular Oncology, University of Chicago, University of Chicago, Department of Physics, University of Chicago, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University, School of Public Health, University of Illinois Chicago

Abstract Preview: Purpose: Gamma Knife (GK) plan quality can vary significantly among planners, even for cases handled by the same planner. Although plan quality metrics such as coverage, selectivity, and gradient inde...

Deep Learning-Based Ventricular Auto-Segmentation for Dosimetric Analysis in Intraventricular Tumor SRS

Authors: John Byun, Juan J Cardona, Steven D Chang, Cynthia Fu-Yu Chuang, Xuejun Gu, Yusuke Hori, Hao Jiang, Fred Lam, Lianli Liu, Weiguo Lu, David Park, Erqi Pollom, Elham Rahimy, Deyaaldeen Abu Reesh, Scott Soltys, Gregory Szalkowski, Lei Wang

Affiliation: Department of Radiation Oncology, Stanford University, Department of Neurosurgery, Stanford School of Medicine, Department of Neurosurgery, Stanford University, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Intraventricular tumors pose significant challenges in neurosurgery due to their complex location. Therefore, brain SRS could be a better treatment option. At our institution, some patient...

Deep Learning–Based Dose Prediction for Automated Proton Radiation Therapy Planning of Breast Cancer

Authors: Ahssan Balawi, Peter Jermain, Timothy Kearney, Sonali Rudra, Michael H. Shang, Markus Wells, Mohammad Zarenia

Affiliation: Department of Radiation Medicine, MedStar Georgetown University Hospital

Abstract Preview: Purpose: To investigate the applicability and accuracy of a deep learning (DL) model in predicting radiation dose distribution for breast cancer patients treated with pencil-beam-scanning proton radio...

Dependency of CT Number on Position in the Field-of-View for Single- and Multi-Energy Images Acquired with Energy-Integrating-Detector and Photon-Counting-Detector CT Scanners

Authors: Yanle Hu, Shuai Leng, Cynthia H. McCollough, Maryam Sadeghian, Joe Swicklik

Affiliation: Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose: To assess the dependency of CT numbers on position in the field-of-view (FOV) using single-energy (SE) and dual-energy (DE) images and energy-integrating detector (EID) and photon-counting de...

Detector Physics-Incorporated Diffusion Denoising Models for Digital Breast Tomosynthesis with Dual-Layer Flat Panel Detectors

Authors: Alexander Bookbinder, Matthew Tivnan, Xiangyi Wu, Wei Zhao

Affiliation: Stony Brook Medicine, Massachusetts General Hospital

Abstract Preview: Purpose: To investigate and benchmark a system-adaptive diffusion-based digital breast tomosynthesis (DBT) denoising model for a direct-indirect dual-layer flat panel detector (DI-DLFPD) with a k-edge...

Determine Noise Weighting Factor in Photon-Counting CT Via Deep Learning for Personalized Noise Reduction

Authors: Xinhui Duan, Roderick W. McColl, Mi-Ae Park, Liqiang Ren, Gary Xu, Kuan Zhang, Yue Zhang

Affiliation: UT Southwestern Medical Center, Department of Radiology, UT Southwestern Medical Center, Imaging Services, UT Southwestern Medical Center

Abstract Preview: Purpose:
Image-based deep-learning noise-reduction techniques have been developed for photon-counting CT (PCCT) to improve image quality with reduced radiation dose. The denoising strength is typic...

Development and Clinical Validation of an Analytical Approach for 3D Positron Emitter Distribution Prediction in Carbon Ion Therapy

Authors: Julia Bauer, Tianxue Du, Katia Parodi, Marco Pinto, Thomas Tessonnier

Affiliation: Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen, Heidelberg Ion Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t MĂŒnchen (LMU Munich)

Abstract Preview: Purpose:
Carbon ion therapy could benefit from range verification due to its sensitivity to range uncertainties. Positron emission tomography (PET) aids in this and comparing irradiation-induced PE...

Development and Implementation of MRI-Only Simulation, Planning and Treatment Workflow for Pelvic Radiotherapy Using Synthetic CT on MR-Linac

Authors: Peter Balter, Elaine Eunnae Cha, Seungtaek Choi, Yao Ding, Eun Young Han, Yusung Kim, Rajat J. Kudchadker, Belinda Lee, Surendra Prajapati, Reza Reiazi, Ergys D. Subashi, Sarath Vijayan, Jinzhong Yang, Yao Zhao

Affiliation: The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: This study evaluates the feasibility of an MR-only simulation, planning, and treatment (MROSPT) workflow for pelvic cancer patients using synthetic CT generated from MRI data. By validating s...

Development and Validation of a Principal Component Analysis Statistical Shape Pediatric/Adolescent Breast Model for Pre-CT Era Breast Dose Reconstruction in Late Effect Studies of Female Childhood Cancer Survivors

Authors: Gregory T. Armstrong, James E. Bates, Kristy K. Brock, Laurence Edward Court, Matt Ehrhardt, Danielle Friedman, Aashish C. Gupta, Donald Hancock, Rebecca M. Howell, Cindy Im, Tera S Jones, Choonsik Lee, Wendy Leisenring, Taylor Meyers, Lindsay Morton, Chaya Moskowitz, Joe Neglia, Vikki Nolan, Caleb O'Connor, Kevin C. Oeffinger, Constance A. Owens, Arnold C. Paulino, Chelsea C. Pinnix, Sander Roberti, Cecile Ronckers, Susan A. Smith, Kumar Srivastava, Lucie Turcotte

Affiliation: Department of Medicine, Duke University School of Medicine, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, The University of Texas MD Anderson Cancer Center, Department of Oncology, St. Jude Children’s Research Hospital, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, Division of Childhood Cancer Epidemiology, University Medicine at Johannes Gutenberg University Mainz, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Pediatrics, University of Minnesota, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Biostatistics, St. Jude Children’s Research Hospital, Clinical Research Division, Fred Hutchinson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences

Abstract Preview: Purpose: To (1) develop and validate a novel anatomically realistic pediatric/adolescent population-based breast model, (2) incorporate model into an age-scalable female reference phantom, and (3) dem...

Development of Preclinical Multiscale Dosimetry for Beta-Particle Emitting Radionuclide in Radiopharmaceutical Therapy

Authors: Adedamola Adeniyi, Bryan Bednarz, Malick Bio Idrissou, Reinier Hernandez, Ohyun Kwon, Brian W. Miller, Zachary S Morris, Maya Takashima, Jamey Weichert

Affiliation: Departments of Radiation Oncology and Medical Imaging, University of Arizona, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Radiology, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin–Madison

Abstract Preview: Purpose: As radiopharmaceutical therapy (RPT) becomes more prevalent in clinical applications, understanding dose-response relationships in the tumor microenvironment (TME) and normal tissues is essen...

Development of a Comprehensive Thoracic Re-Irradiation Database and Investigation of Time-Dependent Dose-Recovery Dynamics for Toxicity Modeling

Authors: Victoria Doss, Tsion Gebre, Rachel B. Ger, Esi A Hagan, Elaina Hales, Russell K Hales, Xun Jia, Heng Li, Dezhi Liu, Todd R. McNutt, Meti Negassa, Anas Obaideen, Tinker Trent, K. Ranh Voong, Cecilia FPM de Sousa

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: As cancer care advances, more patients require re-irradiation, yet evidence-based data is lacking. This study aimed to develop a thoracic re-irradiation database and explore time-dependent re...

Development of a Physical Phantom for Assessing Tube Current Modulation in CT Imaging

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Laura Dinwiddie, Benjamin Taylor Heggie, Adam Leon Kesner, Juan Camilo Ocampo Ramos, Graham Joseph Stoddard

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: The objective of this study is to develop a physical phantom to quantify tube current modulation (TCM) and assess the limitations of a TCM model used in Monte Carlo patient CT organ dose esti...

Differential Gastrointestinal Responses to Synchrotron-Produced Proton and Electron Irradiation Under Flash and Conventional Conditions

Authors: Luke Connell, Nolan M. Esplen, Elise Konradsson, Albert C. Koong, Ziyi Li, Steven Hsesheng Lin, Kevin Liu, Billy W Loo, Devarati Mitra, Radhe Mohan, Emil Schueler, Takeshi Takaoka, Uwe Titt, Xiaochun Wang, Ming Yang

Affiliation: The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: This study aimed to assess radiation-induced gastrointestinal (GI) toxicity in mice subjected to abdominal irradiation using protons at ultra-high-dose-rate (UHDR) and conventional dose-rates...

Direct Dose Verification in Liver SBRT Utilizing an Accumulative Daily CBCT Algorithm

Authors: Michael Buckstein, Yang Lei, Tian Liu, Charlotte Elizabeth Read, Jing Wang, Kaida Yang, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai

Abstract Preview: Purpose: Inter-fraction anatomic variations in liver SBRT can cause significant discrepancies between planned and delivered doses. We developed a CBCT-based accumulative algorithm to directly compare ...

Direct-to-Unit Dose Calculations for Stereotactic Radiosurgery on a C-Arm Linac with Modern on-Board Imaging Solutions

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Haley K Perlow, Alex T. Price, Atefeh Rezaei, Prashant Vempati, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: The HyperSight imaging feature on C-arm linacs(HS-CBCT) offers increased CT number accuracy over conventional on-board imaging. The C-arm geometry allows for noncoplanar treatments common to ...

Dose Dependent White Matter Injuries Quantified By Axial and Radial Diffusivity of Diffusion Tensor Imaging Significantly Correlate with Radiation-Induced Neurocognitive Decline in Diffuse Glioma Patients Underwent Chemoradiation Therapy

Authors: Robert Fucetola, Jiayi Huang, Zhihua Liu, Chongliang Luo, Tong Zhu

Affiliation: Washington University School of Medicine, Washington University in St. Louis, School of Medicine

Abstract Preview: Purpose:
This prospective observational study investigates radiation-induced white matter (WM) injuries using longitudinal diffusion tensor imaging (DTI) in patients with diffuse glioma following r...

Dosimetric Accuracy Evaluation of Brainlab Elements 4.0 Treatment Planning System

Authors: Bhuvaneswari Narayanan, Niko Papanikolaou, Daniel L. Saenz

Affiliation: UT Health San Antonio, University of Texas HSC San Antonio

Abstract Preview: Purpose: To evaluate dosimetric accuracy of Brainlab Elements (BLE) 4.0 treatment planning system (TPS) for linac based SRS and Spine SBRT treatment.
Methods: RT Safe cranial and thorax phantoms wi...

Dosimetric Analysis of Lymphopenia after Lung Irradiation and Modeling the Probability of Normal Tissue Complications

Authors: Tianyuan Dai, Xiaoying Fan, Shuting Wang, Yong Yin

Affiliation: Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: Decreased lymphocytes increase the risk of infections and other problems. Radiation exposure can cause the development of severe lymphopenia. In this study, we used a dynamic blood flow model...

Dosimetric Comparative Analysis of Modulated and Non Modulated Electron Bolus in Nasal Electron Therapy

Authors: Stephen D. Davis, Alonso N. Gutierrez, Noah S. Kalman, Michael Leyva, Alejandro Rene Llanes Lopez, William Romaguera, Ranjini P. Tolakanahalli, Deborah Wang

Affiliation: Miami Cancer Institute, Baptist Health South Florida, Miami Cancer Institute, Miami Cancer Institute, Baptist Health

Abstract Preview: Purpose: To evaluate whether a modulated electron bolus (MEB) technique improves both nominal and shifted dose distributions in nasal electron therapy as compared to a non‑modulated, uniform‑thickness...

Dosimetric Comparison & Error Analysis of Aapm TG51 & WGTG51-e Protocol with Icru-90 Key-Data for High-Energy Clinical Electron Beam

Authors: Amar K. Basavatia, Sandeepan Ganguly, Lee C. Goddard, Wolfgang A. Tomé

Affiliation: Montefiore Medical Center

Abstract Preview: Purpose: To investigate the dosimetric impact of WGTG51-e Report 385, recently updated CoP for clinical electron beams. This study uses a chamber specific effective point of measurement (EPOM) shift t...

Dosimetric Impact of Adaptive Radiotherapy with Ethos for Prostate Cancer: Localized Analysis of Bladder and Rectum across Planned, Non-Adaptive Accumulated, and Adapted Treatments

Authors: Huisi Ai, Scott Glaser, Yi Lao, Percy Lee, Sara N. Lim, An Liu, Bo Liu, Borna Maraghechi, Kun Qing, Chengyu Shi, William T. Watkins, Terence Williams, Qiuyun Xu, Jiahua Zhu

Affiliation: WashU Medicine, Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, City of Hope Orange County, Department of Radiation Oncology, City of Hope National Medical Center, Department of Radiation Oncology, City of Hope Orange County, Department of Radiation Oncology, City of Hope Medical Center

Abstract Preview: Purpose: To employ a novel surface dose mapping approach for localized assessment of the dosimetric impact of Ethos adaptive radiotherapy (ART) for prostate cancer (PC).
Methods: This study include...

Dosimetric Impact of Auto-Segmentation with Replanning: An Analysis of a Prospective Clinical Trial

Authors: Kathryn J. Dess, Martha M. Matuszak, Dan Polan

Affiliation: University of Michigan

Abstract Preview: Purpose: A recent survey demonstrated 18 of 20 top academic institutions have implemented auto-segmentation. Studies to date have focused on geometric contour changes and dosimetric differences using ...

Dosimetric Impact of Calculation Grid Size in ZAP-X Stereotactic Radiosurgery

Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang

Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center

Abstract Preview: Purpose: ZAP-X is the newest cranial stereotactic radiosurgery (SRS) platform. Small-volume structures usually found in the head and neck may be susceptible to dose-volume averaging, which has not bee...

Dosimetric Impact of Monte Carlo Physics Models in Electronic Brachytherapy Simulations

Authors: David Ayala Alvarez, Facundo Ballester, Luc Beaulieu, Francisco Berumen-Murillo, Jean-Simon Cote, Ernesto Mainegra-Hing, Iymad Mansour, Gaël Ndoutoume-Paquet, Jan P. Seuntjens, Rowan M. Thomson, Christian Valdes, Javier Vijande, Peter G. Watson

Affiliation: Département de physique, de génie physique et d'optique, Université Laval, Princess Margaret Cancer Centre & University of Toronto, McGill University, Department of Physics and Medical Physics Unit, McGill University, IFIC-UV, University of Valencia, National Research Council Canada, Carleton University, 5Service de Physique Médicale et de Radioprotection, Centre Intégré de Cancérologie, CHU de Québec- Université Laval et Centre de recherche du CHU de Québec, Nuclear Medicine Department, Hospital Regional de Antofagasta, Université Laval, Carleton Laboratory for Radiotherapy Physics, Department of Physics, Carleton University

Abstract Preview: Purpose: Low-energy X-ray beams used in electronic brachytherapy (eBT) pose unique dosimetric challenges due to high depth-dose gradients, material-dependent detector responses, and the absence of sta...

Dosimetric Impact of Target Coverage with Inter-Fraction Patient Yaw Setup Error in IMRT/VMAT Prostate Cancer Radiotherapy

Authors: Min Su

Affiliation: Mount Sinai School of Medicine

Abstract Preview: Purpose: To evaluate dosimetric impact of patient setup yaw error to target coverage for pelvis/prostate radiation external beam IMRT-VMAT treatment.
Methods: 9 Pelvis/prostate IMRT-VMAT treatment ...

Dosimetric Impact on Patient Roll/Yaw Change for Whole Breast 3D Radiotherapy

Authors: Min Su

Affiliation: Mount Sinai School of Medicine

Abstract Preview: Purpose: To evaluate dosimetric impact of target coverage and organ at risk (OARs) sparing for whole breast patient setup roll/yaw change in 3D-conformal radiotherapy.
Methods: 8 whole breast cases...

Dosimetric Validation and Algorithmic Limitations of Pencil Beam Scanning Proton Therapy for Thin Chest-Wall Treatments

Authors: J Isabelle Choi, Meng Wei Ho, Isabel Lin, Hang Qi, Qi Zeng, Ajay Zheng

Affiliation: New York Proton Center, Scarsdale High School

Abstract Preview: Purpose: Proton therapy is a promising treatment modality for breast cancer due to its unique dosimetric advantage. Accurate dose calculation is critical to ensure effective treatment outcomes. The fo...

Dual-Domain Neural Network Cone-Beam CT Correction for Online Adaptive Proton Therapy

Authors: Daniel H. Bushe, Arthur Lalonde, Hoyeon Lee, Harald Paganetti, Brian Winey

Affiliation: Universite de Montreal, Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, University of Hong Kong

Abstract Preview: Purpose: Improving the precision and fidelity of daily volumetric imaging is essential for enabling adaptive proton therapy (APT). While cone-beam CT (CBCT) provides daily volumetric imaging, their ut...

Dual-Energy CT Derived Perfusion Blood Volume and 4D-CT Derived Ventilation Changes in Lung Cancer Patients 6-Months Post Radiation Therapy

Authors: Daniel A. Alexander, Jeffrey D. Bradley, Steven J. Feigenberg, Cole Friedes, Casey Hollawell, William Levin, Maksym Sharma, Boon-Keng Kevin Teo, Ying Xiao, Nikhil Yegya-Raman, Jennifer Wei Zou

Affiliation: Department of Radiation Oncology and Applied Sciences, Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania

Abstract Preview: Purpose: To investigate lung function changes following definitive chemoradiation dose using CT-derived measurements in patients with locally advanced NSCLC at 6-months post-treatment compared to pre-...

Dual-Modality Protoacoustic and Ultrasound Imaging for Real-Time Monitoring of Proton Therapy In Vivo

Authors: Kristina Bjegovic, Yong Chen, Lucia Rodriguez Gonzalez, Marti Roper, Liangzhong Xiang

Affiliation: University of California, Irvine, University of California Irvine, University of Oklahoma Health Sciences Center, University of Oklahoma Health Science Center

Abstract Preview: Purpose: Proton therapy is an increasingly popular cancer treatment due to its precision, enabled by the Bragg Peak (BP), which minimizes side effects. This profile necessitates in-patient localizatio...

Dysphagia Optimized Knowledge-Based Planning for Head and Neck Cancer

Authors: James E. Bates, Benjamin Hopkins, Kirk Luca, Shadab Momin, Justin R. Roper, Soumon Rudra, Eduard Schreibmann, Bill Stokes, Tu Thi, Xiaofeng Yang

Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: Swallowing dysfunctions after radiotherapy are caused by multiple factors yet are strongly associated with the irradiation of pharyngeal musculature due to its role in the initiation and comp...

Early Imaging Identification of Osteoradionecrosis and Classification Using the Novel Clinrad System

Authors: Serageldin Attia, Zayne Belal, Cem Dede, Clifton David Fuller, Andrew Hope, Laia Humbert Vidan, Kate Hutcheson, Zaphanlene Kaffey, Stephen Y. Lai, Abdallah Mohamed, Amy Moreno, Jillian Rigert, Erin Watson

Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Princess Margaret Cancer Centre, University Health Network, 610 University Ave., The University of Texas MD Anderson Cancer Center, UT MD Anderson, Princess Margaret Cancer Centre, UT MD Anderson Cancer Center, Hospital of the University of Pennsylvania, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Head and Neck Surgery, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology

Abstract Preview: Purpose: Osteoradionecrosis (ORN) of the jaw is a debilitating radiation-induced toxicity lacking standardized classification criteria or treatment guidelines. Early identification of tissue injury co...

Eclipse AFI Manual Planning Versus Brainlab Auto-Planning: A Comparison of SRS Plan Quality

Authors: Dharmin D. Desai, Ellis Lee Johnson, Philip J. Kallenberg, Kapil M. Mishra

Affiliation: Spectrum Medical Physics, University of Kentucky, Varian Advanced Oncology Solutions

Abstract Preview: Purpose: The “Ask For It” (AFI) manual optimization strategy has been shown to generate high quality SRS plans within Eclipse. The purpose of this work is to directly compare manually generated Eclips...

Effects of Communication with Patients on Bladder Sparing in Photon Beam Prostate Treatments

Authors: Nathaniel Haas, David Pearson

Affiliation: University of Toledo

Abstract Preview: Purpose: For external beam treatments for prostate cancer, we ask patients to attend treatments with their bladders full. A full bladder has been shown to reduce the dose to the bladder and bowels for...

Effects of Plan Optimization Techniques on Relative Biological Effective Dose in a Thin Intracranial Target Volume

Authors: Sean P. Boyer, Shae Gans, Mingcheng Gao, Draik B. Hecksel, Mark Pankuch

Affiliation: Northwestern Medicine Proton Center, Northwestern Medicine Chicago Proton Center

Abstract Preview: Purpose: Protons deposit a large portion of their energy at the end of their range in a region known as the Bragg peak, which may increase the relative biological effective (RBE) dose in this region. ...

Electronic Brachytherapy Dosimetric Reference Datasets Using Model-Based Dose Calculation Algorithms

Authors: David Ayala Alvarez, Facundo Ballester, Luc Beaulieu, Francisco Berumen-Murillo, Jean-Simon Cote, Ernesto Mainegra-Hing, Iymad Mansour, Gaël Ndoutoume-Paquet, Rowan M. Thomson, Christian Valdes, Javier Vijande, Peter G. Watson

Affiliation: Département de physique, de génie physique et d'optique, Université Laval, Laval University, Princess Margaret Cancer Centre, McGill University, Department of Physics and Medical Physics Unit, McGill University, IFIC-UV, University of Valencia, National Research Council Canada, Carleton University, 5Service de Physique Médicale et de Radioprotection, Centre Intégré de Cancérologie, CHU de Québec- Université Laval et Centre de recherche du CHU de Québec, Nuclear Medicine Department, Hospital Regional de Antofagasta

Abstract Preview: Purpose: Modelling electronic brachytherapy (eBT) sources is difficult because of the high-dose gradients and challenges associated with low-energy modelling. This study examines the accuracy of avail...

Enhance Four-Dimension Cone-Beam Computed Tomography (4D-CBCT) from Sparse Views Using a Novel Deep Learning Model

Authors: Lei Ren, Jie Zhang

Affiliation: University of Maryland School of Medicine

Abstract Preview: Purpose: 4D-CBCT is valuable for imaging anatomy affected by respiratory motions to guide radiotherapy delivery. However, 4D-CBCT often has undersampled projections acquired in each respiratory phase ...

Enhanced Prediction of Iroc Stereotactic Radiosurgery Phantom Audit Results with Treatment Parameters, Complexity Metrics, DVH, and Dosiomics Using Machine Learning

Authors: Lian Duan, Stephen F. Kry, Hunter S. Mehrens, Christine Peterson, Paige A. Taylor

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To develop predictive models for IROC SRS head phantom audits and to identify important factors influencing institutional performance.
Methods: The IROC SRS head phantom includes two TLDs ...

Enhancing Daily QC for Photon-Counting CT: Incorporating 40 keV VMI Evaluations with the ACR CT Phantom

Authors: Lakshmi Ananthakrishnan, Xinhui Duan, Liqiang Ren, Gary Xu, Kuan Zhang, Yue Zhang

Affiliation: Department of Radiology, UT Southwestern Medical Center, Imaging Services, UT Southwestern Medical Center

Abstract Preview: Purpose: Daily quality control (QC) programs for diagnostic CT include water CT number (HU), standard deviation (SD), and visual artifact evaluations. At our institution, 70 keV virtual monoenergetic ...

Enhancing Image Quality in Acoustic Imaging Using the Segment Anything Model (SAM)

Authors: Jadon Buller, Zhuoran Jiang, Yankun Lang, Lei Ren, Leshan Sun, Liangzhong Xiang, Yifei Xu

Affiliation: University of Maryland School of Medicine, University of California, Irvine, University of California, Stanford University

Abstract Preview: Purpose: Electroacoustic tomography (EAT) and Protoacoustic (PA) imaging are novel modalities for treatment verification of electroporation and proton therapy. However, the limited acquisition angle i...

Enhancing the CT Contrast Via Attention-Gated Contrast Enhancement Gan (AGCE-GAN)

Authors: Nan Li, Yaoying Liu, Shouping Xu, Xinlei Xu, Gaolong Zhang

Affiliation: School of Physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, School of physics, Beihang University, Beihang University, Department of Radiation Oncology

Abstract Preview: Purpose:
CT simulation is essential for radiation therapy preparation but has limitations in distinguishing lesions. Contrast-enhanced CT (CECT) improves lesion detection and characterization, but ...

Estimating Organ Dose of Standard Pediatric CT Protocols to Computational Phantoms through the Dukesim CT Simulator

Authors: Dean Darnell, Iyanna M Lewis, Francesco Ria, William Paul Segars

Affiliation: Duke University, Duke University Medical Physics Graduate Program, Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Duke University Medical Center

Abstract Preview: Purpose: To estimate radiation dose to pediatric patients during standard CT imaging of the chest and abdomen and determine how dose varies with patient age, height and weight and how measurements com...

Evaluating Stent-Induced Dose Perturbations in Intravascular Brachytherapy with EBT4 Films

Authors: Yijian Cao, Jenghwa Chang, Nicholas Coupey, Lyu Huang, Jessica Jung

Affiliation: Northwell, Hofstra University Medical Physics Program

Abstract Preview: Purpose:
The Synergy bioabsorbable polymer (BP) stent, made of Platinum Chromium Alloy, is widely utilized in treating coronary artery disease. This study investigates dose perturbations caused by ...

Evaluating Uncertainty Estimation Models for Clinical Integration of AI-Generated Radiotherapy Dose Distributions

Authors: Jacob S. Buatti, Kristen A. Duke, Malena Fassnacht, Neil A. Kirby, Parker New, Niko Papanikolaou, Arkajyoti Roy, Yuqing Xia, Michelle de Oliveira

Affiliation: The University of Texas San Antonio, UT Southwestern Medical Center, UT Health San Antonio

Abstract Preview: Purpose:
Quantifying and visualizing uncertainty is critical for building clinical trust in AI-generated dose distributions. This study evaluates Monte Carlo Dropout (MCD), Snapshot Ensemble (SE), ...

Evaluating a Novel Solution for GYN Planning: Integrated Dynamic Collimator Rotation and Static Angle Modulated Ports with a New Optimizer

Authors: Ben Archibald-Heeren, Grace Gwe-Ya Kim, Kelly Kisling, Xenia Ray

Affiliation: UC San Diego, Icon Cancer Centres, University of California, San Diego, University of California San Diego

Abstract Preview: Purpose: To evaluate improvements in external beam plans for gynecological cancers from a novel planning solution: RapidArc Dynamic (RAD) (Varian Medical Systems, Palo Alto, CA) which optimizes VMAT w...

Evaluation of Concomitant Imaging Dose in 4D-CBCT Guided Thoracic Radiotherapy

Authors: Yuchao Hu, Yajun Jia, Zhangmin Li, Yong Sang, Jianan Wu, Man Zhao

Affiliation: Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Radiation Oncology, Guangzhou Concord Cancer Hospital, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose: To evaluate the imaging dose of 4D-CBCT in patients treated with thoracic radiotherapy.
Methods: A model of the Elekta XVI imaging system was created in TOPAS software. Percentage depth do...

Evaluation of Dose-Rate Metrics in Intensity Modulated Proton Therapy for Prostate Cancer Treatments

Authors: Stella Flampouri, Edgar Gelover, William Andrew LePain, Roelf L. Slopsema, Alexander Stanforth, Mingyao Zhu

Affiliation: Emory Healthcare, Emory University

Abstract Preview: Purpose: Little consideration was given to the change in dose rate (DR) observed when moving to pencil beam scanning (PBS). This study reports on DR in clinical prostate PBS plans. While dose distribu...

Evaluation of Fractional Variability in High-Risk Clinical Target Volume (HR-CTV) during High-Dose-Rate Brachytherapy for Cervical Cancer: A Retrospective Analysis for Adaptive Treatment Planning.

Authors: Olubunmi Odunola Aregbe, Clara Ferreira, Margaret Reynolds, David A. Sterling, Jianling Yuan

Affiliation: University of Minnesota, University of Minnesota Physicians, Department of Radiation Oncology, University of Minnesota, Minneapolis

Abstract Preview: Purpose: To analyze volume changes in the high-risk clinical target volume (HR-CTV) during high-dose rate (HDR) brachytherapy for cervical cancer patients. The study aims to evaluate the trend and cor...

Evaluation of Hybrid Dynamic Conformal Arc Planning for SRS and SBRT Treatment

Authors: Pat Esposito, Ashley Klein, Carmine Verna, Ling Zhuang

Affiliation: Northwestern Medicine

Abstract Preview: Purpose: To evaluate dosimetric parameters and treatment delivery efficiency between volumetric modulated arc therapy (VMAT) and hybrid dynamic conformal arc (HDCA) on SRS and SBRT planning through st...

Evaluation of Phosphorus-32 Source Uniformity Using Python Algorithm and Monte Carlo Simulation

Authors: Ana Laura Burin, Ilca Marli Moitinho Amaral Medeiros, Priscila Santos Rodrigues, Maria Elisa Chuery Martins Rostelato, Sabrina Spigaroli Sgrignoli, Ana Catarina Koka de Souza Silva, Carla Daruich Souza, Cristhian Ferreira Talacimon, Lara El Hajj Teodoro, Carlos Alberto Zeituni

Affiliation: IPEN - USP, IPEN - Instituto de Pesquisas Energéticas e Nucleares

Abstract Preview: Purpose: The uniform distribution of phosphorus-32 (32P) in beta sources is essential to ensure the accuracy of radiotherapy treatments, such as those for paravertebral cancer. This study evaluated th...

Evaluation of Thoracic Direct Dose Calculation Using Truebeam Linac with Hypersight Imaging CBCT Solution

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Alex T. Price, Sagar Regmi, Atefeh Rezaei, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: To investigate the feasibility and accuracy of using a Hounsfield Unit(HU) calibrated cone-beam computed tomography(CBCT) for direct dose calculation in thoracic treatment settings. In combin...

Evaluation of the Improvements of a New Leaf Model (Enhanced Leaf Model) for the Halcyon

Authors: Evan Barber, Gloria P. Beyer, Callum Hartley, Jordi Saez, Philip Wheeler

Affiliation: Department of Radiation Oncology, Hospital Clinic de Barcelona, Department of Radiotherapy Physics, Velindre University NHS Trust, Medical Physics Services, LLC

Abstract Preview: Purpose: To evaluate the Enhanced Leaf Model (ELM) in Eclipse v18 to the standard leaf model for the Halcyon multileaf collimator (MLC) using a measurement-based method.
Methods: The Halcyon’s doub...

Experience in Commissioning and Quality Assurance of Halcyon Linear Accelerator Ver3.0 at a Community Hospital and an Academic Institution

Authors: Emily Y. Hirata, Xiaoyu Sherry Liu, Evan Porter, Manju Sharma

Affiliation: University of California San Francisco, University of California, San Francisco, University of California

Abstract Preview: Purpose:
The Varian Halcyon Linear Accelerator has become increasingly popular in both community hospitals and academic institutions due to its user-friendly design and operational efficiency. This...

Exploring the Universal Correlation between DNA Damage Distribution and Cell Surviving Fraction in Photon, Proton, and Carbon Ion Irradiations

Authors: Lawrence F. Bronk, Fada Guan, Xun Jia, Youfang Lai, Miao Qi

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: DNA double-strand breaks (DSBs) are widely regarded as critical indicators of cellular response to ionizing radiation. This study aims to establish a direct, unbiased and universal correlatio...

Fast 3D Scintillation Dosimetry Using Single View Deep Learning Reconstruction

Authors: Louis Archambault, Nicolas Drouin, Alexis Horik, Simon Thibault

Affiliation: Département de Physique, de Génie Physique et D'optique, et Centre de Recherche sur le Cancer, Université Laval, Département de Physique, de Génie Physique et D'optique, et Centre d'optique, photonique et laser, Université Laval

Abstract Preview: Purpose: To develop a novel type of real-time 3D dosimeter for the quality assurance of linear accelerators used in external beam radiotherapy.
Methods: An experimental setup was constructed using ...

Fast Synthetic-CT-Free Dose Calculation in MR Guided RT

Authors: Claus Belka, Stefanie Corradini, George Dedes, Nikolaos Delopoulos, Christopher Kurz, Guillaume Landry, Ahmad Neishabouri, Domagoj Radonic, Adrian Thummerer, Niklas Wahl, Fan Xiao

Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, LMU Munich, Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)

Abstract Preview: Purpose: In MR-guided online adaptive radiotherapy, MRI lacks tissue attenuation information necessary for accurate dose calculations. Instead of using deep learning methods to generate synthetic CT i...

Feasibility and Dosimetric Impact of Intensity-Modulated Radiotherapy for Cervical Cancer Patients in Nepal: A Retrospective Analysis

Authors: Daniela Branco, John M Bryant, Surendra Bahadur Chand, Pratiksha Shahi, Joseph Weygand

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, B.P. Koirala Memorial Cancer Hospital, , B.P Koirala Memorial Cancer Hospital, University of California San Diego / California Protons, Department of Radiation Oncology, Moffitt Cancer Center

Abstract Preview: Purpose:
Cervical cancer remains a significant health burden in Nepal, with 2169 new cases and 1313 deaths recorded in 2022. This study evaluates the feasibility of implementing step-and-shoot IMRT...

Feasibility of Rapidarc Dynamic for Lattice Radiation Therapy of Bulky Liver Tumors

Authors: Christine V. Chung, Laurence Edward Court, Meena S. Khan, Ethan B. Ludmir, Rachael M. Martin Paulpeter, Saurabh Shashikumar Nair, Callistus M. Nguyen, Joshua S. Niedzielski, Luis Augusto Perles

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Spatially Fractionated Radiation Therapy (SFRT) has re-emerged as an efficacious treatment approach for bulky solid tumors. RapidArc Dynamic (RAD) has unique beam delivery capabilities that m...

Finding the Best Match of 4D-CT Phases to Delineate Volumes for Bgrt

Authors: Resat Aydin, Joseph Barbiere, Brett Lewis, Roland Teboh

Affiliation: HUMC, Hackensack University Medical Center

Abstract Preview: Purpose:
Accurately compensating for respiratory-induced tumor motion is critical in BgRT, where precise delineation of volumes ensures effective dose delivery. We propose an integrated approach th...

Four-Dimensional Computed Tomography Based on 16cm-Long Detectors Vs 4cm-Long Detectors: Dose Validation

Authors: Qianyi Xu, Inhwan Yeo

Affiliation: INOVA Schar Cancer Institute, Thomas Jefferson University

Abstract Preview: Purpose:
Four-dimensional computed tomography(4DCT) is prone to a geometrical error when respiration changes upon patient shift. 4DCT with a longer-length detector(16cm), uninvolving the shift, has...

Four-Dimensional on-Beam Computed Tomography Reconstruction from Projection Image Differences Representing Motion Change

Authors: Kwang-Ho Cheong, Seungryong Cho, Joonil Hwang, Jae Won Jung, Hoyeon Lee, Raymond Hyunwoo Moon, Inhwan Yeo, Jihyung Yoon

Affiliation: East Carolina University, INOVA Schar Cancer Institute, University of Hong Kong, Hanllym University, KAIST, University of Rochester

Abstract Preview: Purpose: Monitoring a target and neighboring organs during beam delivery is crucial for successful radiotherapy (RT). Conventional transit imaging methods lack volumetric reconstruction capabilities, ...

From Concept to Clinic: A Phase-Based Approach for Implementing Auto-Segmentation in Radiation Therapy

Authors: Elizabeth L. Covington, Robert T. Dess, Charles S. Mayo, Michelle L. Mierzwa, Dan Polan, Jennifer Shah, Claire Zhang

Affiliation: University of Michigan, Department of Radiation Oncology, University of Michigan

Abstract Preview: Purpose: Auto-segmentation improves contour consistency and standardization in radiation therapy but may introduce variations from current practices, potentially impacting treatment outcomes and toxic...

Functional Liver Image Guided Radiation Planning Using MRI with a Contrast Agent

Authors: Kenneth L. Homann, Natalie A Lockney, Hong Zhang

Affiliation: Department of Radiation Oncology, Vanderbilt University Medical Center, Vanderbilt University Medical Center

Abstract Preview: Purpose: The aim of this study is to develop a treatment planning methodology utilizing liver functional imaging via contrast-enhanced Magnetic Resonance Imaging (MRI) in patients undergoing stereotac...

Geometric Alignment of MV-CBCT and Dual-Layer Kv-CBCT Projections Using Deep Learning

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Applications of combined kV-MV CBCT include metal artifact correction and material identification. Difficulties arise, however, when the imagers have misaligned geometric perspectives of the ...

Geometrically Derived Density Compensation Function for 3D Non-Cartesian MRI Reconstruction

Authors: Oluyemi Bright Aboyewa, KyungPyo Hong, Daniel Kim

Affiliation: Department of Radiology, Northwestern University

Abstract Preview: Purpose: While non-Cartesian MRI is desirable for fast imaging with high spatial resolution and robustness to motion, it requires long post-processing times. Preconditioning with an adequate density c...

Gradient-Based Radiomics for Outcome Prediction and Decision-Making in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR): A Preliminary Study

Authors: Michael Dohopolski, Jiaqi Liu, Hao Peng, Robert Timmerman, Zabi Wardak, Haozhao Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
This study introduces a gradient-based radiomics framework to enhance outcome prediction in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR) for brain metastases...

High-Quality Patchnet (HQ-PatchNet) for Synthetic CT Generation in Head & Neck Imaging

Authors: So Hyun Ahn, Chris Beltran, Byongsu Choi, Jeong Heon Kim, Jin Sung Kim, Bo Lu, Justin Chunjoo Park, Bongyong Song, Jun Tan

Affiliation: Mayo Clinic, Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Ewha Medical Research Institute, Ewha Womans University College of Medicine, UC San Diego, Yonsei University College of Medicine

Abstract Preview: Purpose:
Cone-beam computed tomography (CBCT) is widely used in IGRT for patient positioning but suffers from low resolution and poor soft tissue contrast. Synthetic CT (sCT) generated from CBCT ad...

Image Guidance for Mitigating the Impact of Table Walkout on Delivered Dose in Non-Coplanar Stereotactic Radiotherapy

Authors: William E Burrell, Philip F. Durham, Anne N Hubbard, Yohan Akeakamai Walter, Hsinshun Terry Wu

Affiliation: Willis Knighton Cancer Center

Abstract Preview: Purpose: Linear accelerator (LINAC)-based single-isocenter, multi-target (SIMT) treatment has streamlined the stereotactic radiosurgery (SRS) workflow. However, off-isocenter treatment carries multipl...

Impact of Ion Chamber Selection on Enhanced Leaf Modeling Predictions of Dosimetric Leaf Gap and Leaf Transmission Factors

Authors: Michael Ashenafi, Nicholas Becerra Espinosa, Mario Ramos Gallardo, Matthew Pacella, Sean M. Tanny

Affiliation: Department of Radiation Oncology, University of Rochester

Abstract Preview: Purpose: A new multileaf collimator (MLC) model has been introduced in Varian Eclipse v18.0, with the treatment planning system (TPS) explicitly modeling the leaf end effects. The vendor recommends a ...

Impact of Photon Beam Energy and Symmetry on the Radial Profile Correction Factor for FFF Beams

Authors: Wesley S. Culberson, Larry A. DeWerd, Ahtesham Ullah Khan, Zachary James Welchel

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison

Abstract Preview: Purpose: Flattening filter free (FFF) linac beams exhibit a centrally peaked beam profile due to the forward-directed bremsstrahlung production from MeV electrons, leading to volume averaging effects ...

Impact of Positron Emission Tomography (PET) Image Characteristics on Biology-Guided Radiotherapy (BgRT) Treatment Accuracy

Authors: Angela J Da Silva, Andrew Groll, Manoj Narayanan, Jeffrey Schmall, Sanchit Sharma, Timothy Pok Chi Yeung

Affiliation: Reflexion Medical Inc,, RefleXion Medical

Abstract Preview: Purpose: PET-based biology-guided radiotherapy (BgRT) is a radiation therapy technique that uses PET imaging to deliver tracked dose to the tumor in real-time. We characterized the delivery accuracy o...

Impact of Proton Beam Arrangements on LETd and RBE in Organs at Risk for Nasopharyngeal Cancer

Authors: Mauricio Acosta, Zachary Fellows, Alonso N. Gutierrez, Noah S. Kalman, Kristen A. McConnell, Rob Rohe, Andrew J. Wroe, Sreenija A Yarlagadda

Affiliation: Miami Cancer Institute, Baptist Health South Florida

Abstract Preview: Purpose:
Beam selection is crucial in proton therapy to ensure optimal physical and biological dose conformity to the target while maximizing sparing of normal tissue. This work investigates the im...

Implementation of a Virtual Quality Assurance System Using Raystation for Online MR-Linac Adaptive Radiotherapy

Authors: Min-Sig Hwang, Danny K. Lee, Daniel C. Pavord, Kyung Lim Yun

Affiliation: Allegheny Health Network

Abstract Preview: Purpose: Ensuring the quality of treatment plans through patient-specific pre-treatment quality assurance (QA) is essential. However, the use of physical phantom-based QA devices is not feasible for o...

Improvements from Monte Carlo Simulations over Pencil Beam Algorithms for Normal Tissue Dose Reconstruction in Proton Therapy Patients

Authors: Amy Berrington de Gonzalez, Keith T Griffin, Jae Won Jung, Cari M Kitahara, Choonik Lee, Choonsik Lee, Aimee L McNamara, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock

Affiliation: University of Michigan, East Carolina University, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School, Institute of Cancer Research

Abstract Preview: Purpose: Radiotherapy dose reconstruction enables retrospective epidemiological studies that connect late health effects to the organ-absorbed radiation doses received during treatment. Though clinica...

Improving Segmentation Precision in Prostate Cancer Adaptive Radiotherapy with the Intentional Deep Overfit Learning (IDOL) Approach

Authors: Seungryong Cho, Donghyeok Choi, Joonil Hwang, Byung-Hee Kang, Jin Sung Kim, Eungman Lee, Younghee Park

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, KAIST, Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Ewha Womans University of Medicine

Abstract Preview: Purpose: Radiation therapy (RT) is critical for cancer treatment, but changes in tumor size and shape during therapy challenge precise dose delivery. Adaptive radiation therapy (ART) addresses these v...

Improving TG-263 Target Name Compliance Using Locally-Hosted Large Language Models

Authors: Rex A. Cardan, Carlos E. Cardenas, Udbhav S. Ram

Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham

Abstract Preview: Purpose: The AAPM TG-263 report provides nomenclature guidelines for target and normal tissue structures used in radiation oncology. Adherence to these guidelines is challenging for targets, as there ...

In-Vivo Dosimetry in Positron-Guided Radiation Therapy

Authors: Davide Brivio, Erno Sajo, Ryan Williams, Piotr Zygmanski

Affiliation: University of Massachusetts Lowell, Brigham and Women's Hospital, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School

Abstract Preview: Purpose: To develop a non-invasive 3D in-vivo dosimetry tool exploring the relationship between positron annihilations and dose per voxel using Monte Carlo simulation. The Positron Guided Radiation Th...

Influence of Intrafraction Motion on the Dosimetry of Prostate Treatments

Authors: María Fernåndez, Inés Flores, Nuria Montero, Manuel Ruiz, Francisco San Miguel

Affiliation: Hospital Central de la Defensa 'GĂłmez Ulla', Hospital Central de la Defensa "Gomez Ulla", CSVE, Hospital Central de la Defensa 'GĂłmez Ulla', CSVE

Abstract Preview: Purpose:
During external radiotherapy treatments in the prostate, there can be PTV movements between fractions and during each treatment fraction. In a typical prostate treatment in our institution...

Innovative Biological Adaptive Radiotherapy (BART) Approach for Head-and-Neck Cancer Treatment Interruptions

Authors: Nobuki Imano, Daisuke Kawahara, Akito S Koganezawa, Yuji Murakami, Ikuno Nishibuchi, Takuya Wada

Affiliation: Department of Information and Electronic Engineering, Faculty of Science and Engineering, Teikyo University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University

Abstract Preview: Purpose: Adaptive radiotherapy (ART) compensates for treatment plans based on anatomical changes while not considering biological effects such as interruptions during treatment. This study aims to dev...

Inter-Patient Registration Methods for Voxel-Based Analysis in Lung Cancer

Authors: Chloe Min Seo Choi, Joseph O. Deasy, Jue Jiang, Sudharsan Madhavan, Nikhil Mankuzhy, Nishant Nadkarni, Andreas Rimner, Maria Thor, Harini Veeraraghavan, Abraham Wu

Affiliation: University of Freibrug, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Voxel-based analysis (VBA) requires accurate topology-preserving inter-patient deformable image registration (DIR). This study assessed whether guiding a DIR method with geometric priors of t...

Inter-System and Inter-Layer Dlg Variations in Halcyon/Ethos Mlcs: Implications for Dosimetric Matching and User-Adjustable TPS Models

Authors: Evan Barber, Gloria P. Beyer, Matthew J. Daniels, Callum Hartley, Jordi Saez, Philip Wheeler

Affiliation: TrueNorth Medical Physics, Department of Radiotherapy Physics, Velindre University NHS Trust, Department of Radiation Oncology, Hospital Clinic de Barcelona, Medical Physics Services, LLC

Abstract Preview: Purpose: To quantify inter-system and inter-layer dosimetric leaf gap (DLG) variations in Halcyon/Ethos multileaf collimators (MLCs) using custom sweeping gap tests, and to evaluate implications for c...

Investigating X-Ray Flash Effect on Plasmid DNA with Combined Microscopic Monte Carlo and Analytical Simulations

Authors: Xun Jia, Youfang Lai

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University

Abstract Preview: Purpose: Ultrahigh dose rate FLASH (>40 Gy/s) radiotherapy (RT) has attracted significant attention. The mechanism remains unclear, hindering clinical translation. This study investigated the behavior...

Investigating the Effect of Beam Flattening Filter on Dose Estimated with Varian’s Original and Enhanced Mlc Models

Authors: Kenny Guida, Hongyu Jiang, Harold Li, Hem Bahadur Moktan Tamang

Affiliation: University of Nebraska Medical Center, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Varian Eclipse v18.0 introduced Enhanced Leaf Model (ELM) of MLC, which provides better dose calculation accuracy than original DLG-based MLC model. The leaf-gap (LG) parameter for ELM repres...

Investigating the Flash Effect: Uncovering Brain Sparing and Cognitive Preservation across Varying Dose Rates in Whole-Brain Irradiation of in-Vivo Mouse Models

Authors: Denise Dunn, Scott R. Floyd, Tyler V. Kay, Anna Lynnette-Price, Eric L. Martin, Stepan Mikhailov, Taylor Nguyen, Mark Oldham, Victoria J. P. Radosova, Zachary J. Reitman, Ramona Rodriguiz, Andrew Thompson, William Wetsel, Seth Wilcox, Ying Wu

Affiliation: Duke University Mouse Behavior Core, Department of Physics, Duke University, Medical Physics Graduate Program, Duke University, Duke University Medical Physics Program, Duke University, Duke University Mouse Behavioral and Neuroendocrine Analysis Core Facility, Department of Radiation Oncology, Duke University Medical Center

Abstract Preview: Purpose: FLASH radiation therapy (RT) shows promise for reducing normal tissue damage, though its mechanisms remain unclear. Using an in-vivo model with the High Intensity Gamma-ray Source (HIGS) lina...

Investigating the Radiation Chemistry of Flash Radiation Therapy through Electron Paramagnetic (EPR) Spectroscopy

Authors: Ramin Abolfath, Alexander Baikalov, Stefan Bartzsch, Nolan M. Esplen, Alan Eduardo Lopez Hernandez, Emil Schueler

Affiliation: MD Anderson Cancer Center, PI Experimental Medical Physics, Institute of Radiation Medicine (IRM), Helmholtz Munich, Germany, Howard University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: FLASH radiation therapy (FLASH-RT) leverages ultra-high dose rates (UHDR) to spare normal tissue as compared to conventional (CONV)-RT while preserving tumor control; this is termed the FLASH...

Knowledge-Based Deep Residual U-Net for Synthetic CT Generation Using a Single MR Volume for Frameless Radiosurgery

Authors: Justus Adamson, John Ginn, Yongbok Kim, Ke Lu, Trey Mullikin, Xiwen Shu, Chunhao Wang, Zhenyu Yang, Jingtong Zhao

Affiliation: Duke University, Duke Kunshan University

Abstract Preview: Purpose:
To develop a knowledge-based deep model for synthetic CT (sCT) generation from a single MR volume in frameless radiosurgery (SRS), eliminating the need for CT simulation prior to the SRS d...

Knowledge-Based Three-Dimensional Dose Prediction for High Dose Rate Prostate Brachytherapy

Authors: Mojtaba Behzadipour, Suman Gautam, Tianjun Ma, Ikchit Singh Sangha, Bongyong Song, William Song, Kumari Sunidhi

Affiliation: UC San Diego, Virginia Commonwealth University

Abstract Preview: Purpose: This study aims to develop a knowledge-based voxel-wise dose prediction system using a convolutional neural network (CNN) for high-dose-rate (HDR) prostate brachytherapy and to evaluate its p...

LD-V1 Film Characterization for MV Beam Quality

Authors: Ruiming Chen Edmondson, Darwin Abraham Garcia, James A. Kavanaugh, Joseph John Lucido

Affiliation: Mayo Clinic

Abstract Preview: Purpose: Characterize the dose response and reproducibility of a low-dose film for 6 MV photon beam and assess the film’s energy dependence between kV and MV energies.
Methods: A single 8’x10’ LD-V...

Lesion Detection in Contrast Enhanced Cone Beam Breast CT with a Photon Counting Detector: A Monte Carlo Study

Authors: Ahad Ollah Ezzati, Xiaoyu Hu, Xun Jia, Youfang Lai, Kai Yang, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Massachusetts General Hospital, Johns Hopkins University

Abstract Preview: Purpose: Contrast-enhanced breast cone-beam computed tomography (bCBCT) provides high-resolution, 3D imaging of breast tissues with improved differentiation between normal and abnormal tissues. Curren...

Lu-PSMA-Dose, a French Retrospective Multicentric Dosimetry Study of 177Lu-PSMA Treatments for Metastatic Castration-Resistant Prostate Cancer

Authors: NadÚge Anizan, Jean-Noël Badel, Thomas Baudier, David Broggio, Désirée Deandreis, Ludovic Ferrer, Didier Franck, Camilo Garcia, Jean Gasteuil, Anne-Laure Giraudet, Olivier Humbert, Laetitia Imbert, Malick Koulibaly, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard, Caroline Rousseau, Guido Rovera, David Sarrut, Paul Schwartz, Nicolas Varmenot

Affiliation: Institut de CancĂ©rologie de l’Ouest, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de Physique MĂ©dicale, Institut BergoniĂ©, Service de Physique MĂ©dicale, CHRU de Nancy Brabois, Service de MĂ©decine NuclĂ©aire, Centre de lutte contre le cancer LĂ©on BĂ©rard, UniversitĂ© de Lyon, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, UniversitĂ© Nice CĂŽte d’Azur, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de MĂ©decine NuclĂ©aire, Institut de CancĂ©rologie de l’Ouest, Service de Physique MĂ©dicale, Service de MĂ©decine NuclĂ©aire, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon; Centre de lutte contre le cancer LĂ©on BĂ©rard, Institut BergoniĂ©, Service de MĂ©decine NuclĂ©aire

Abstract Preview: Purpose: The main objective of the Lu-PSMA-Dose study, sponsored by ASNR, is to estimate retrospectively the individual absorbed dose delivered to patients treated with 177Lu-PSMA for metastatic castr...

Lung Mass Variability in Clinical Chest CT Imaging with Automatic Contouring Tool

Authors: Yasaman Anbari, Srinivas Cheenu Kappadath, Benjamin P. Lopez

Affiliation: University of Houston, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To improve lung dosimetry for 90Y-radioembolization planning, CT-based techniques have been proposed for patient-specific lung mass estimation instead of assuming nominal 1 kg lung masses. He...

Management of 4D CBCT Dose for Patients with Implanted Cardiac Devices

Authors: Won Chang, Vadim L. Stakhursky, Yevgeniy Vinogradskiy

Affiliation: Jefferson Einstein, Alliance Cancer Specialists, Thomas Jefferson University

Abstract Preview: Purpose: 4DCBCT is a powerful tool for localization of moving targets when treating lung tumors with hypofractionated regimens (SBRT). However, for patients with implanted cardiac devices (ICD) in clo...

Material Modulated 3D Printed Human-Tissue Simulant Phantoms for Radiation Therapy Modeling and Safety

Authors: Joseph A. Moore, Paul Rothweiler, Jussi K. Sillanpaa, Adhvaith Sridhar

Affiliation: University of Minnesota

Abstract Preview: Purpose: To investigate 3D printed human tissue simulant phantoms for use in radiation therapy and to quantify the mechanical and radiation properties of these phantoms.
Methods: We designed and 3D...

Maximum Conformity IMPT Planning with the Dynamic Collimation System

Authors: Wesley S. Culberson, Albert Du, Ryan T. Flynn, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake

Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Iowa, Iowa Health Care

Abstract Preview: Purpose:
To perform end-to-end treatment planning and delivery verification of energy-specific collimated treatments optimized to achieve the maximum obtainable high-dose conformity using the dynam...

Mesial Temporal Tau-PET Is Related to Diffusion Tensor Imaging Outcomes in Adults with Down Syndrome

Authors: Andrew Alexander, Brecca Bettcher, Bradley T Christian, Jose Guerrero-Gonzalez, Steven Kecskemeti, Lisette LeMerise, Max McLachlan, Andrew McVea, Matthew Zammit

Affiliation: University of Wisconsin-Madison School of Medicine and Public Health and Waisman Center

Abstract Preview: Purpose: Individuals with Down syndrome (DS) develop Alzheimer’s Disease (AD) with very high prevalence (>90%). Neuropathology includes amyloid plaque (AÎČ) accumulation, followed by neurofibrillary ta...

Mitigating Data-Driven Uncertainty in Machine Learning-Based Radiotherapy Outcome Prediction

Authors: Ali Ajdari, Alice Bondi, Thomas R. Bortfeld, Gregory Buti, Xinru Chen, Zhongxing Liao, Antony John Lomax, Ting Xu

Affiliation: The University of Texas MD Anderson Cancer Center, Department Of Radiation Oncology, Massachusetts General Hospital (MGH), Massachusetts General Hospital & Harvard Medical School, Paul Scherrer Institut, ETH Zurich

Abstract Preview: Title: Addressing Imaging and Biomarker-driven Uncertainty in Machine Learning-based Radiotherapy Outcome Prediction
Alice Bondi, Gregory Buti, Antony Lomax, Thomas Bortfeld, Xinru Chen, Ting Xu, Z...

Modeling Alpha-Particle Dose from Diffusing Alpha-Emitters Radiation Therapy in Tissue with Inhomogeneous Diffusion

Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang

Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...

Monte Carlo Simulation and Dosimetric Verification of 3D Range Modulators for a Multi-Field-Optimization Flash-IMPT Plan

Authors: Michael M Folkerts, Miriam Krieger, Pierre Lansonneur, Gerard Paquet, Petar Penchev, Christoph Schuy, Yuri Simeonov, Uli Weber, Klemens Zink

Affiliation: GSI Helmholtzzentrum fuer Schwerionenforschung, Institute of Medical Physics and Radiation Protection (IMPS), University of Applied Sciences, Varian Medical Systems

Abstract Preview: Purpose:
Ultra-high dose-rate proton irradiation may spare the healthy tissue (FLASH-effect). The 3D-range-modulator (3D-RM) method reduces the treatment time compared to conventional IMPT and can ...

Multi-Institutional Analysis of CT Dose Index Variability and Radiomics Features

Authors: Caroline Chung, Michael Knopp, Stephen F. Kry, Hunter S. Mehrens, John Rong

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, University of Cincinnati

Abstract Preview: Purpose: To evaluate the variability of CT dose index (CTDIvol) and radiomics features across a large cohort of radiotherapy simulation CT scans from multiple institutions.
Methods: Three IROC phan...

Multi-Path Deep Learning Model for Predicting Post-Radiotherapy Functional Liver Imaging in Patients with Hepatocellular Carcinoma

Authors: Smith Apisarnthanarax, Stephen R. Bowen, Sunan Cui, Jie Fu, Clemens Grassberger, Yulun He, Yejin Kim, Matthew J. Nyflot, Sharon Pai

Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Washington, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Department of Physics, University of Washington, University of Washington and Fred Hutchinson Cancer Center

Abstract Preview: Purpose: 99mTc-sulfur colloid SPECT imaging enables quantitative assessment of voxel-wise liver function in patients with hepatocellular carcinoma (HCC). Accurately predicting post-radiotherapy (RT) l...

Multi-Vendor Validation of a Deep Learning-Based Synthetic CT Generation Model for MR-Only Radiotherapy Planning in the Pelvis

Authors: Gregory Bolard, Rabten Datsang, Sarah Ghandour, Timo Kiljunen, Pauliina Paavilainen, Sami Suilamo, Katlin Tiigi

Affiliation: Turku University Hospital, Virginia Commonwealth University, MVision AI, North Estonia Medical Centre, Docrates Cancer Center, Hopital Riviera-Chablais

Abstract Preview: Purpose: To verify the performance of a vendor-neutral deep learning model for synthetic CT generation from T2-weighted and balanced steady-state MR sequences to support both MR-only simulation and MR...

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Authors: Houssam Abou Mourad, Christopher Ackerman, Stephen Adler, Kirk Aduddell, Muhammad K. Afghan, Hamid G. Aghdam, Diego Aguilar, Kang-Hyun Ahn, Francis Ai, Hua Ai, Ray Anthony Aikens, Manik Aima, Victoria Ainsworth, Erfan Akbari, Blessing Akinro, Rani Al-Senan, Khalid Alabbasi, Sam Alam, Daniel Alexander, Mohammed H. Aljallad, Mazin T. Alkhafaji, Ahmad K. Alkhatib, Scott J. Alleman, James Logan Allen, Ibtisam Almajnooni, Tiba Alnaqshabandi, Murat Alp, Stephen J. Amadon, Riska Amilia, Ala Amini, Shiho Amster, Mason R. Anders, Erin Angel, Ledi Anggara, John A. Antolak, Debora Antonio, Felicity Appiah, Haiqa Arain, Lahcen Arhjoul, Ali V. Aritkan, Muhammad Arshad, Mark E. Artz, Nathan S. Artz, Frank A Ascoli, John R. Ashburn, Benjamin Astarita, Masakazu Atsumi, Rex G. Ayers, Tara M. Bachman, Nina L. Bahar, Bing Bai, Michael J. Bailey, Chris Baird, Mohammad Bakhtiari, Andrew J. Ballesio, Isabel Balvoa, Qinan Bao, Jeffrey J. Barbarits, Joseph Barbiere, Philip C. Bardos, Gary T. Barnes, John C. Barrett, Divya Bartley, Steven J. Bartolac, Robert Barton, Christopher P. Bass, Loni Bates, Alan Baydush, John E. Bayouth, Stephen Beach, Kevin Beaudette, Kaelyn Becker, Natalie A. Beckmann, Colleen Beer, Sepideh Behinaein, Jake M. Bell, David M. Bellezza, Maria R. Bellon, Ahmed Benelfassi, Stephanie Louise Bennett, Todd Bernath, Kate Bevins, Nicholas B. Bevins, Brian J. Bismack, David Blaich, Anthony P. Blatnica, Joseph W. Blickenstaff, Steven Blum, Maggie Bobbett, Dayna Bodensteiner, Daniel Boedeker, Robert C. Boggs, Jason D. Bond, Sjirk N. Boon, Jennifer M. Borsavage, Ryan J. Bosca-Harasim, Ryan J. Bosca-Harasim, Satya R. Bose, Todd Bossenberger, Cristina Boswell, Djamal Boukerroui, Christopher M. Bowen, Aaron Brammer, Rich Brancaleoone, Eric Brass, Luis Bravo, William Breeden, Christina Breeze, Eric E. Brost, Justin L. Brown, Karen L. Brown, Marissa Brown, Norman Lee Brown, Payton Brown, Patrick V. Brunick, Ryan Brunkhorst, Gwendolyn P. Brunner, Camelia E. Bunaciu, Maria Bunta, Olwen Burton, Karim Butalag, Priscilla F. Butler, Angela Cagwin, Jeffrey L. Campbell, Warren G. Campbell, Tyler Cantrell, Xu Cao, Yanan Cao, Peter F. Caracappa, Amanda M. Caringi, Joe Caron, Joshua Carter, Kenneth W. Cashon, Sarah Castillo, Everett Cavanaugh, Suran Chae, Abhi Chakrabarti, PhD, Philip Chan, Jina Chang, Sha X. Chang, Youssef M. Charara, Pierre E. Charpentier, Priyanka Chaudhary, Senthamil Selvan Chelliah, Chen Chen, Doris Chen, Kuan Ling Chen, Max Chen, Mingyue Chen, Mu Chen, Xinan Chen, Yie Chen, Yong Chen, Caroline Cheney, Shyh-Shi R. Chern, Stephen Thomas Chesser, Kin Man Cheung, Pai-Chun Melinda Chi, Yuwei Chi, Omar Chibani, Hung Ching, Gwi Ae Cho, Jongmin Cho, David Choi, Wing Yan Choi, Nitish Chopra, Daniel Christ, Olav I. Christianson, Emmanuel Christodoulou, Heeteak Chung, Sophia Claudio, Arely Clavel, William J. Clouse, Gilad Cohen, Michael S. Cohen, Vladimir Collantes, Jason Collier, Jacob Collins, Daria C. Comsa, Charles Conduah, Virgil N. Cooper, Anita M. Corrao, Frank D. Corwin, Mihaela Cosma, Ben Coull-Neveu, Mary K. Cox, Daniel F. Craft, Steven D. Crawford, Troy M. Crawford, Charles E. Creagh, Beatrice Croteau, Camille Crumbley, Wilbert F. Cruz, Guoqiang Cui, J. Adam M. Cunha, Scott Cupp, Bruce H. Curran, Jordan McCauley Cutsinger, Alita D Almeida, Harold DSouza, Nana Dabo-Akoteng, Robert Dahl, Shaun W. Dahl, Ghayath Dakkouri, Malek Daneshvarnezhad, Mylinh Dang, Matt Daniels, George M. Daskalov, David A. Davenport, Amanda Davidek, Scott E. Davidson, Maria De Ornelas, Dylan A. DeAngelis, Mike Deady, Daniel Dean, Savannah Decker, Savannah Decker, Michael Delafuente, Omer Demirkaya, Logan Dempsey, Marc Dennis, Viv Dennis, Dana Derby, Garron A. Deshazer, Veronique Destombes, Ajaya K. Devabhaktuni, Suneetha Devpura, James A. Deye, Shalmali Dharmadhikari, Dominic J. DiCostanzo, Richard V. DiPietro, Emily Diller, Lei Ding, Nayha V. Dixit, Charles Dodge, David N. Dodoo Amoo, Shana Donchatz, Lei Dong, Elangovan Doraisamy, Jennifer E. Dorand, Sarah Driver, Jiayi Du, Michael Duax, Ibrahim M. Duhaini, Ibrahim Duhaini, Kristen Duke, Richard Dunia, Leon Dunn, Shannon R. Durfee, Brittany Earl, Behzad Ebrahimi, Colton Eckert, Hisham Elasmar, John G. Eley, Abdelhamid Elfaham, David C. Ellerbusch, Scott J. Emerson, Sara Endo, David Erickson, Freddy Escorcia, Caroline Esposito, Patrice Essien, Adam Evearitt, Benjamin Fahimian, Liliosa C. Fajardo, Kevin Fallon, Guoqing Fan, Jiahua Fan, Mingdong Fan, Pei Fan, Bing Fang, Jian Fang, Yile Fang, Marc A. Felice, Ye Feng, Michele Sutton Ferenci, Philippe Feru, Jade Alecia Fischer, Aaron Fishbein, Caitlyn M. Fitzherbert, Damian Fondevila, Grant Fong, Robert Wesley Foster, Luke Fourie, Jeffrey Brian Fowlkes, Alexandre Franca Velo, D. Jay Freedman, Ronald W. Frick, Jie Fu, Samuel Fulton, Kamalakar Gaddam, Justin D. Gagneur, Mariana Gallo, Mariana Gallo, David Gammel, Robert G. Gandy, Junfang Gao, Yiming Gao, Victor L. Garcia, Michael Garcia-Alcoser, Jeffrey Garrett, Steven Anthony Gasiecki, Keith Gatermann, Avinash Gautam, Bhoj Gautam, Olivier Gayou, Andrew J. Gearhart, Paul B. Geis, Renil B. George, David P. Gierga, Robert Gilliam, James Giltz, Eric L. Gingold, Frederic Girard, Garth Gladfelder, Sharon Glaze, Brendan K. Glennon, Steven P. Glennon, Guy Godwin, David Lloyd Goff, Lisa M. Goggin, Daniel Goldberg-Zimring, Edward Joseph Goldschmidt, Ehsan Golkar, Angel Gomez, Jason Gong, Manish K. Goyal, Frank Graeff, Royce L. Gragg, Jonathan Gray, Alexander D. Green, Olga L. Green, Andrew Christopher Greene, Travis Greene, Jared Grice, Kevin T. Grizzard, Suveena Guglani, Jeffrey B. Guild, Patrick P. Guo, Sandesh Gupta, Megan Gute, Jonathan Ha, Rachael L. Hachadorian, Christopher Haddad, Lubomir Hadjiiski, Scott W. Hadley, Tomoe Hagio, Kelsey Hall, Logan P. Hall, Klaus A. Hamacher, Amineh Hamad Khatib, Amineh O. Hamad Khatib, Brian R. Hames, Carnell Hampton, Samuel S. Hancock, Robyn S. Handschuh, Jeremy Hansen, Paul Harden, Joseph Harms, Daniel P. Harrington, Carley Harris, Jamie Marie Harris, Jennifer Hart, Richard P. Harvey, Jeremy Hawk, Naoki Hayashi, Maria Laura Haye, Katherine Hazelwood, David Hearshen, Bret H. Heintz, Adam Henry, Frank William Hensley, Michael Chris Hermansen, Marissa Hernandez, Nadia Hernandez, Dayadna Hernandez Perez, Sarah Hetherington, Emily Hewson, Maynard High, Brian P. Hill, Charles B. Hill, Yunsil Ho, Simeon Hodges, David M. Hoeprich, Michael N. Hoff, Robert F. Hoffman, Russell Holden, Clay Holdsworth, Scott Hollingsworth, John R. Holmes, Steve Holmes, Neal S. Holter, Thomas M. Holtschneider, Amirul Hoque, Sabbir Hossain, Tyler S. Howlin, Andrew Robert Hoy, An Ting Hsia, Hao-Yun Hsu, David Hu, Tom C. Hu, Yu-Chi Hu, Long Huang, Mi Huang, Joshua Hubbell, Michael J. Huberts, Julie C. Hudson, Geoffrey Hugo, Donglai Huo, Justin D. Hurley, Martina H. Hurwitz, Mohammad NASEEM Hussain, Andrew Hwang, Ui-Jung Hwang, Joe Ianni, Geoffrey Ibbott, Khalil Ibrahim, Ileana Iftimia, Mohammad Islam, Oleksandra Ivashchenko, Keyvan Jabbari, Joshua Jackson, Joshua Jackson, Ferenc Jacso, Mary Ellen Jafari, Karim Jaffer, Amit Jain, Ngoneh Jallow, Sachin R. Jambawalikar, Joshua A. James, Sunyoung Jang, Desiree Jangha, Tomaj Javidtash, Jun-Hsuang Jen, Peter Jenkins, Todd P. Jenkins, Andrew R. Jensen, Mads Lykke Jensen, Hosang Jin, Bowen Jing, Danielle Marie Johnson, Joshua D. Johnson, Holly Johnston, Kevin Jones, Badal R. Juneja, Nikhil Sriram Kabilan, Robert Kaderka, Jaclyn Kain, Faraz Kalantari, Maduka M. Kaluarachchi, Ali Kamen, Amrit Kaphle, Alireza Kassaee, Saravjeet Kaur, Vaiva Kaveckyte, Linda A. Kelley, Katelyn Kelly, Kathryn Elise Bales Kelly, Delsin B. Khan, Om Khanal, Maksud Khatri, William Steadman Kiger, Bryan Kim, Jong Oh Kim, Sangroh Kim, Sophia Kim, Brian W. King, Erica Kinsey, Assen S. Kirov, Marc T. Kleiman, Matic Knap, Robert J. Kobistek, Inger-Karine Kolkman-Deurloo, Erika Kathryn Kollitz, Dramane Konate, Xiang Kong, Walter Kopecky, Sandra Kos, Nataliya Kovalchuk, Shane Krafft, James A. Kraus, Robert Krauss, Deae-eddine Krim, Serguei Kriminski, Kerry T. Krugh, Lichung Ku, Esra Kucukmokroc, Randi Kudner, Andrew T. Kuhls-Gilcrist, Antti Juhani Kulmala, Akila D. Kumarasiri, Zacariah E. Labby, Taylor Lackey, Edcer Jerecho Laguda, Thang Lam, Michael A. S. Lamba, Kara Lambson, Laurel Zenaida Larramendi, Andy D. Lau, Wolfram Laub, Tyler Laugh, Robert P. Laureckas, Donald Laury, Patricia Lavey, Ashlie Laydon, Adam LeVay, Brandon Lee, Brian Lee, Dong-Chang Lee, Ji Hyun Lee, Jui-Min Lee, Bryan Lemieux, Matthew Lesher, Nicole Leslie, Etienne Lessard, Trish Lewis, Alan Li, Alexander N. Li, Hui Li, Jenny Li, Jiaxin Li, Qiongge Li, Taoran Li, Xiang Li, Yanlong Li, Zisheng Li, Xing Liang, Yun Liang, Chien-Yi Liao, Karisa Liaw, Sung-Yen Lin, Tiffany Lin, Holly M. Lincoln, Lin Ling, Chang Liu, Shaohua Liu, Yu Liu, Chih-Ming Mark Lo, Eric Lobb, Dilson Lobo, Virginia L. Lockamy, Lauren C. Long, Nelia S. Long, Troy Long, Michele Loscocco, Thomas Lowinger, Cynthia Lu, Minghui Lu, Winnie Lu, Yonggang Lu, Jianqiao Luo, Pei-Chin Luo, Xuhan Luo, Jan Luse, Daniel A. Lutterman, Dang Hoang Oanh Luu, Yulia Lyatskaya, Trina Lynd, Morgan Cervo Lyon, Chi Ma, Jingfei Ma, Tianjun Ma, Laurie Madden, Gregory E. Madison, Kurt Maffei, Michael J. Maffett, Nyasha G. Maforo, Dennise Magill, Emma Magness, Alphonso W. Magri, Dennis Mah, Usman Mahmood, Rebecca N. Mahon, Courage Mahuvava, Andrew D. Maidment, Gerassimos M. Makrigiorgos, Harish K. Malhotra, Kate Mallory, P. Scott Mange, Vivek Maradia, Jacob Marasco, Camilla Marino, Loren R. Marous, Wagner Marques, Craig M. Marsden, Edward I. Marshall, Jonathan Marshall, Caroline Martel, Colin Martin, Alejandro Martinez, Jeffrey P. Masten, Richard Mathew, Bobby Mathews, Anetia S. Matthews Jackson, Matthew R. Maynard, Joel R. McAllister, Rafe McBeth, James A. McCulloch, Kiernan T. McCullough, Keelin McGee, Kiaran P. McGee, Brian M. McGill, Christopher M. McGuinness, Robert McKoy, Steven M. McQuiggan, Lacey Medlock, Chirag D. Mehta, Nancy Meiler, Robert Meiler, Matthew A. Meineke, Caroline Melancon, Daniel S. Meleason, Carolyn Meltzer, Chunhua Men, Stephanie Merkl, Michael Merrick, Keith A. Michel, Georgeta Mihai, Ana Mihail, Devin A. Miles, Edward J. Miller, Elizabeth A. Miller, Ronaldo Minniti, Linda Minor, Filmon Misgina, Ajeet Kumar Mishra, Chad Mitchell, Drew P. Mitchell, Gregory S. Mitchell, Jessica Mitchell, Jacqueline Moga, Uwe Mollenhauer, Julien-Fabrice Ngoune Momo, Emi Mondragon, Nicholas Mongillo, Victor J. Montemayor, Scott Montgomery, Diego Luis Montufar Hidalgo, Mohammadamin Moradi, Serban Morcovescu, Jill Anna Moreau, Terrance Moretti, Toby Morris, Courtney K. Morrison, Alexander Albert Morrow, Jill Moton, Jonathon Mueller, Reshma Munbodh, Daniel W. Mundy, Daniela Murgulet, Scott A. Murphy, Benjamin C. Musall, Jana E. Musgrove, Samantha Musial, Yong Hum Na, Joel Nace, Paul Naine, Justin Napolitano, Vrinda Narayana, Ganesh Narayanasamy, Moulay Ali Nassiri, Muhammad Naveed, Richard D. Nawfel, Ritish Nedunoori, Aaron Nelson, Kristin J. Nelson, Aaron Nelson, MD, Neerajan Nepal, Emily Neubauer Sugar, Shree Neupane, David Newey, Mark Newpower, Susan Ng, Bau H. Nguyen, Daniel J. Nicewonger, Xingyu Nie, Ethan Nikolau, Kevin D. Nitzling, Kai Niu, John M. Noll, Prashanth K. Nookala, Khalid Noori, James T. Norweck, Hamidreza Nourzadeh, Jessica L. Nute, Sebastiaan Nysten, Kevin OGrady, Ceferino Obcemea, Keith Ober, Jacqueline Ogburn, Timilehin Ogunbeku, Mina Okello, Brian Olson, Martin Keane Ongeti, Savannah Orrill, Joseph Ott, Bahadir Ozus, Jan Pachon, Alexis Paige-Glenn, Jason Paisley, Farideh Pak, Randahl C. Palmer, Kiran Pant, Virginia Pappas, Abby Pardes, So-Yeon Park, Alexis Parker, Karla Parker, Homayon Parsai, Tommy O. Parsons, Pankaj Patel, Amy Patrick, Johnlly G. Pattaserial, Lindsey M. Patton, Taylor J. Patton, Nava R. Paudel, Timothy John Paul, Colin Paulbeck, Olga V. Pen, Cheng Peng, Yuanlin Peng, Carmelo Perez, Dominik Peruƥko, Alexander Pevsner, Douglas Pfeiffer, Melanie Piantino, Daniel Piatigorski, Rajesh Pidikiti, Natalie Piechowska, Greg Pierce, Tina Pike, Donika Plyku, Robert Pohlman, Mariela Adelaida Porras-Chaverri, Subechhya Pradhan, Guillem Pratx, Chris Proctor, Alexander Pryanichnikov, Diane Pugel, Yue Qiu, Adam C. Quinton, Todd Racine, Andrea Radine, Dustin K. Ragan, Balasubramanian Rajagopalan, Kishore Rajendran, Eric V. Ramirez, Mehdi Ramshad, Vijay K. Rana, Brianne Raulston, Amy K. Readshaw, Hailey Reaux, Ian Reineck, Xuemin Ren, Meral L. Reyhan, Davenport Ria, Matthew J. Riblett, Kenneth M. Richardson, Rebecca F Richardson, Matthew Richeson, Ashlyn Rickard, Adam Riegel, Lynn N. Rill, Miguel A. Rios, E. Russell Ritenour, Scott P. Robertson, Marthony L. Robins, Rebecca Robinson Rey, Steve Rodney, Priscila Rodrigues, Edgardo Rodriguez, Tino Romaguera, Emilie Roncali, Joseph E. Roring, Alison R. Roth, Lawrence N. Rothenberg, Nick Rothwein, Kricia Emilia Ruano Espinoza, Damian DG Rudder, Donald R. Ruegsegger, Erwin W. Ruff, Brandon J. Russell, Frederick Rustad, Narayan Sahoo, Jonathan H. Saleeby, Habeeb H. Saleh, Flavio Salinas Aranda, Steffen Sammet, Daniel Sandoval, Aman Sangal, Joseph P. Santoro, Maíra Santos, Alexis Marie Sanwick, Milind Sardesai, Vikren Sarkar, Duminda Satharasinghe, Jessica L. Saunders, Carmen Sawyers, Sarah B. Scarboro, James Scheuermann, Colleen G. Schinkel, Dale Schippers, Joshua William Schlegel, David J. Schlesinger, Charles Ross Schmidtlein, Erich Schmitz, Jose Schneider, Erich A. Schnell, Lisa Schober, Leah Schubert, Michelle L. Schwer, James Seekamp, Jennifer Seger-Paisley, J. Anthony Seibert, Balaji Selvaraj, Raj N. Selvaraj, Meredith A. Semon-Pomposelli, Lasitha Senadheera, Naima Senhou, Christopher F. Serago, Hananiel Setiawan, Shakil B. Shafique, Aarti Shah, Hina Shah, Alok Shankar, Ryan Shanks, Kritika Sharma, Sunil K. Sharma, Jennifer M. Shealy, Ron Sheen, Gina L. Shelton, Mohammad Ullah Shemanto, Zion Sheng, Andrew J. Shepard, Justin R. Sherman, Kaizhong Shi, Xiaolin Shi, J. Allen Shih, Taciana Soares Shiue, Deborah J. Shumaker, Noah Silverberg, Ramon Alfredo C. Siochi, Amogh Sirniirkar, Marlene Skopec, Michael G. Skowronski, Dana Smetherman, Erika Smith, Eileen Sneeden, Jesse Snyder, James C. So, Emilie Soisson, Nima Soltani, Kwang Hyun Song, Liang Song, Xiaoling Song, Jigar B. Soni, Yashvant C. Soni, Jagadeesh R. Sonnad, Michael A. Speidel, Michael P. Speiser, James D. Speitel, Tanya Spellman, Joseph Patrick Speth, Daniel J. Spitznagel, Sara T. St. James, Alexander Stanforth, George Starkschall, James Stebelton, James P. Steinman, Jonathan M. Stenbeck, Robin L. Stern, Patrick D. Stevens, Erika Stewart, Gary Stinnett, Sarah A. Strand, Keith J. Strauss, Kristen Stryker, Edward Sudentas, Kevinraj N. Sukumar, Orhan H. Suleiman, John L. Sullivan, Paul Robert Sullivan, Mei Sun, Peng Sun, Kumari Sunidhi, Jacob Sunnerberg, Elizabeth A. Swanson, William J. Swanson, Larry E. Sweeney, Sean Swiedom, Gregory Szalkowski, Katsuyuki Taguchi, MohammadAli Tajik-Mansoury, Reza Taleei, Derek Tang, Shengzhang Tang, Mahin Tariq, Jason S. Tavel, Neelima Tellapragada, Alexandra Tellez, Dawn Tellez, Juan Manuel Tellez, Xiaokun Teng, James A. Terry, Biniam Tesfamicael, Confex Test, Aapm Tester, Contex Tester, Namita Thakur, David J. Theel, Kathleen D. Thomas, Emily A. Thompson, Stephen K. Thompson, Daniela Thorwarth, Kevin Tierney, Anders Tingberg, Ragu S. Tirukonda, Robert A. Tokarz, Robert J. Tokarz, Naresh B. Tolani, Brian Tom, Shidong Tong, Ebrahim Torangan, Martin Tornai, Diana Tovmasian, Trung Tran, Bryan Traughber, Samuel Trichter, Sugata Tripathi, Petra Trnkova, Panagiotis Tsiamas, Ryan Tsiao, Haifeng Tu, Philip N Tubiolo, Jeff D. Turley, Adam Turner, PhD, DABR, Conner Ubert, Chibueze Zimuzo Uche, Vincent M. Ulizio, Gnanaprakasam Vadivelu, Hema Vaithianathan, Sunil Valaparla, Fabiola Vallejo Castañeda, Liesbeth Vancoillie, Matt Vanderhoek, Caroline Vanderstraeten, Nancy J. Vazquez, Linda A. Veldkamp, Trevor L. Vent, Anthony M. Ventura, Keith Ver Steeg, Irina Vergalasova, CHENG WANG, Christopher Waite-Jones, Matthew C. Walb, Reuben Waldron, Arlie Vester Walker, Jim Walsh, Alisa I. Walz-Flannigan, Cheng Wang, Helen H. Wang, Hui-Chuan Wang, Jiali Wang, Jian-xiong Wang, Kai Wang, Kyle Wang, Ning Wang, Yuntao Wang, Zhendong Wang, Zhixing Wang, Grace Ward, Sarah M. Way, Rachel L. Waymire, Melvin Weatherly, Charles Travis Webb, Lincoln J. Webb, Jia Wei, Wenbo Wei, Callie Weiant, Miriam S. Weiser, Eric M. Welch, Jered R Wells, Michelle C. Wells, S. Brock Westlund, Gerald A. White, John White, Darunee S. Whitt, David Wikler, Austin Wilkinson, Carly D. Williams, Mark Bennett Williams, Joshua M. Wilson, Keli C. Wilson, Nicholai Wingreen, Joseph Wishart, Alon Witztum, Katherine M. Woch Naheedy, Andy Wolf, Serkalem E. Wondimgezhu, Genevieve N. Wu, Wenhao Wu, Ye Wu, Yuxiang Xing, Li Xiong, Weijun Xiong, Xunyi Xu, Yan Xu, Tianyou Xue, Yanjie Xue, Girijesh K. Yadava, Derek Z. Yaldo, Kaiguo Yan, Yue Yan, Nathan E. Yanasak, Bowen Yang, Ray Yang, Xiaocheng Yang, Yun Yang, Yunze Yang, Bin Yao, Yuan (John) Yao, Anna N Yaroslavsky, Feng-Ju Yeh, Susanne Yerich, Michael V. Yester, Xiaofei Ying, Tekeste Yohannis, Tony Younes, Eyesha Younus, Jialu Yu, Justin Yu, Yan Yu, Pui Kuen Yuen, Joshua P. Yung, Steve Yuvan, Mehran Miron Zaini, Ramtin Zakikhani, Lee Anne Zarger, Merissa Zeman, Lisa Zent, Di Zhang, Dongqing Zhang, Hao Zhang, Jun Zhang, Lei Zhang, Lu Zhang, Maochen Zhang, Peng Zhang, Peng Zhang, Qingyun Zhang, Xin Zhang, Yi Zhang, Yinghui Zhang, Yongbin Zhang, Zhongwei Zhang, Bo Zhao, Xuandong Zhao, Yizhou Zhao, Weiping Zheng, Yi Zheng, Troy Zhou, Xiangzhi Zhou, Xiaohong Joe Zhou, Yuwei Zhou, Jin Zhu, Mingyao Zhu, Eric C. Zickgraf, John R. Zullo, Piotr Zygmanski, Leo van Battum

Affiliation: DTC Consultants, NL Health, Dartmouth Hitchcock Medical Center, ProCure Proton Therapy Center, Medical & Radiation Physics, Inc, Augusta University, Genesis Healthcare Partners, Michigan Medicine, Washington DC VA Medical Center, VA Medical Center, Mercy Southeast Hospital, Food And Drug Administration, University of Iowa, Advanced Radiation Physics Service, Inc, University of Pittsburgh, University of Wisconsin, Wellspan Health, Good Samaritan Hospital, Howard University Hospital, St. Mary's Memorial Health Center, Penn State Milton S. Hershey Med Ctr., New York Weill Cornell Medical Ctr, X-Ray Computations, Inc., US Navy, Penn State Health, Kelsey Seybold Clinic, Advocate Aurora, Fresno Cancer Center, Central Alabama Radiation Oncology, Riverside Methodist Hospital Ohio Health, Alliance Medical Physics, OCSRI, AAPM, University of Minnesota, University of Virginia Health System, PGIMER, Barrigel, Johns Hopkins Univ, Appex Physics Partners, BoxElder Research, University of Oklahoma Health Sciences Center, Sanford Roger Maris Cancer Center, Berkshire Medical Center, New York Weill Cornell Medicine, Mobimed Technologies, University of Chicago Medicine, Johns Hopkins Medicine, Maimonides Medical Center, Nuvance Health - Vassar Brothers, Crozer Keystone Health System, Karmanos/McLaren, Vanderbilt University, Panhandle Cancer Care Center, The University of Michigan, Piedmont Healthcare, Gamma Medical Physics LLC, Mississippi Baptist Medical Center, Astarita Associates Inc, Landauer Medical Physics, RPS Oncology, Zhejiang University, University of North Carolina School of Medicine, University of Kentucky HealthCare, Peninsula Regional Medical Center, Varian Advanced Oncology Solutions, New York Proton Center, Wake Forest University Medical Center, Rutgers Robert Wood Johnson Medical School, Tx Oncology, Lewis Hall Singletary Oncology Center (John D. Archbold Hospital), Medical Physics Services, University of New Mexico, UPMC Cancer Center, Medical Physics Solutions, LLC, ECU Health, Evercare Hospital Chattogram, Mercy Cancer Center, Sharp Grossmont Hospital, West Virginia University, Virginia Commonwealth University Medical Center, Thomas Jefferson University, Centennial Medical Physics, LLC, University of California, Davis, University of Miami, Varian, Inc., UAB Medical Center, Wellspan health, Cleveland Clinic Foundation, Procure Treatment Center, Retired FDA, Tufts Medical Center, Virginia Commonwealth University, Germantown Academy, Hartford Hospital, Cleveland Clinic Florida, Billings Clinic, Imalogix, University of Wisconsin - Madison, Dana Farber Cancer Institute, Massachusetts General Hospital, Johns Hopkins University, GenensisCare, VARIAN Siemens Healthineers, MedStar Washington Hospital, Illawarra Cancer Care Center, Duke Health, Corewell Health, Columbia University, Johns Hopkins, Baylor Scott & White Health, Ascension Saint Thomas Rutherford Hospital, Varian, a Siemens Healthineers company, Rabin Medical Center, Albany - Stratton VA, Florida Cancer Specialists at Tampa Cancer Center, Baylor St Lukes Medical Center, Baylor College of Medicine, Christiana Care Health System, West Physics, Mayo Clinic Arizona, Emory University, University of Pittsburgh Medical Center, Brigham and Women's Hospital, UCLA, CoxHealth, Starsino Medical Technologies Co Ltd, University of Utah Hospitals, Lahey Health Medical Center, Paul Scherrer Institute (PSI), Karmanos Cancer Institute, Radcom Associates, LLC, Ascension Wisconsin, The University of Alabama at Birmingham, Winter Park Cancer Center, Louisiana State University, UT Health San Antonio, Intermountain Health, Penn Medicine/Lancaster General Health, Elekta Xoft, University of KY HealthCare, Rutgers, Cancer Institute of New Jersey, Real Time Tomography LLC, Toronto Metropolitan University, UCSD, Dartmouth College, Ascension St. Thomas Rutherford hospital, City of Hope, Radiation Management Associates, Levine Cancer Institute, Atrium Health, Varian Medical Systems, Blount Memorial Hospital, Penn State University, Therapy Physics, Inc., Northwest Community Hospital, Duke University Medical Center, Advent Health, Miami Cancer Institute, Washington State Department of Health, Lantheus Medical Imaging, Chesapeake Potomac Regional Cancer Center, MRP Inc., University of Chicago, University of Tennessee Medical Center, Huntsman Cancer Institude, University of Utah, Oregon Health and Science University, Hutchinson Regional Medical Center, Winchester Medical Center, WellSpring Oncology, Medical School of East Carolina Univ, Weill Cornell Medical Center, UPMC Hillman Cancer Centers, Springfield Clinic, CaliberMRI, Inc., Prisma Health, Helen F. 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Ohio Medical Physics Consulting, West Michigan Cancer Center, University Hospitals Cleveland Medical Center, Levine Cancer Institute/Atrium Health, Advanced Biophotonics Laboratory, University of Massachusetts Lowell, UConn Health, U.S. Nuclear Regulatory Commission, Wayne State University, University of Oklahoma Health Science Center, Houston Methodist Hospital, Varian, Arizona Center for Cancer Care, NIH Clinical Center, Stanford University, Hospital of the University of Pennsylvania, Peel Regional Cancer Center, Credit Valley Hospital, University of Alabama Birmingham, Lark Physics, Ackerman Cancer Center, Southern District Health Board, Milestone Medical Physics Group, UTHealth Houston McGovern Medical School, Rutgers University, West County Radiological Group, Mayo Clinic, Philips Healthcare, University of Vermont Medical Center, Novant Health at Presbyterian Medical Center, Harvard Medical School, Ratio Therapeutics, Naval Medical Center Portsmouth, University Colorado Denver, School of Medicine, Sutter Santa Cruz Radiation Oncology, Radiophysics Associates, Northside Hospital, SolutionHealth, University of Virginia Health Systems, Johns Hopkins School of Medicine, Austin Health, UPMC, St. Joseph Mercy Health System, Cancer Center of Hawaii, Centra Health, Aspekt Solutions, Winter Haven Hospital, Henry Ford Hospital System, Medical University of South Carolina, Maine Medical Center, Phoenixville Hospital, National Institutes of Health, Associated Medical Professionals, Gundersen Health System, St. Luke's University Health Network, Univesity of Victoria, Department of Radiation Oncology, Stanford University School of Medicine, Washington University in St. Louis, Queen's Medical Center, West O'ahu, Canon Medical Research USA, Inc., Robert Wood Johnson University Hospital, UVA Health System, Section for Biomedical Physics, Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University TĂŒbingen, Centennial Medical Physics, McLaren Cancer Institute, Cancer Care Group, Texas Oncology-Tyler, CTSI Oncology Practice Solutions, a varian company, Bank of Cyprus Oncology Centre, Columbus Regional Hospital, Central Florida Cancer Insititute, Texas Oncology - San Antonio, The Ohio State University, Stony Brook University, Greenwich Hospital, INOVA Schar Cancer Institute, Marsden Medical Physics Associates, Allegheny Health Network, Geisinger Health System, University of Maryland Medical System, Texas Oncology, Mount Sinai Medical Center, TrueNorth Medical Physics, Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, Houston Methodist Hospital, Houston, TX, Martin Memorial Medical Center, Yale University School of Medicine, Comprehensive Cancer Centers of Nevada, ASR Institute for Cancer Care, Research & Rehabilitation, University of Louisville Brown Cancer Center, Jaeger Corporation, UC San Francisco, Inova Hospital at Fairfax, Upstate Medical Physics, Cedars-Sinai Medical Center, Brown University Health, Texas Oncology-Denton, Assarian Cancer Center, HCA Healthcare, San Diego State University, Cooper University HealthCare, LVeldkamp MedPhys Services, LLC, Morristown Medical Center, Atlantic Health System, OMPC Therapy, LLC & OMPC Diagnostic, LLC, Defense Health Agency, Radiation Oncology, Medical College of Wisconsin, UT Southwestern Medical Center, Kaiser Permanente Bellflower Medical Center, Roswell Park Comprehensive Cancer Center, University of Victoria, MD Anderson Cancer Center at Cooper, Siemens Healthineers, Monmouth Medical Center, Memorial Sloan Kettering Cancer Center, Ironwood Cancer & Research Centers, University of Cincinnati, School of Medical Sciences, Fujita Health University, University of Kentucky/UK HealthCare, University of California, San Francisco, Instituto Nacional do Cancer, Brazil, IBA Dosimetry GmbH, Westchester Medical Center, Ohio State Univ, Houston Methodist, Medical College of Wisconsin, Columbia University Medical Center, Department of Radiation Oncology, College of Medicine, University of Arkansas for Medical Sciences, UT MD Anderson Cancer Center, DFCI/BWCC south shore, Providence Cancer Center, Memorial Sloan-Kettering Cancer Center, American Association of Physicists in Medicine, Lynn Cancer Institute - Radiation Oncology, Renown Health, Purdue Univ, Beth Israel Deaconess Medical Center, Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Holy Family Hospital, OhioHealth, IBA Dosimetry, Memorial Hospital Gulfport, University of Florida, George Washington Univ, University of Cincinnati Medical Center, Hubbard, Zickgraf, & Broadbent, Accuray Inc, UVRMC, MIM Software, Massachusetts General Hospital and Harvard Medical School, Mem. Sloan Kettering Cancer Ctr, UF Health Proton Therapy Institute, California Medical Physics, Inc., Henry Ford Health, UPMC Hillman Cancer Center, Vanderbilt University School of Medicine, Saddleback Memorial Medical Center, Stony Brook University Medical Center, University of Pennslyvania, TOP Physics Consulting, Nuvance/Norwalk Hospital, Oregon Health & Science Univ, Brigham & Women's Hospital, University of Pennsylvania, McLaren – Greater Lansing, American Board of Radiology, Penn Medicine | Virtua Radiation Oncology, University of Tennessee, OneOncology, University of Colorado, Indiana University Medical Center, Stronach Regional Cancer Centre, Yale New Haven Health, Vanderbilt University Medical Center, Emory Healthcare / Winship Cancer Institute, Cape Fear Valley Radiation Oncology, Northwell Health, Sutter Health, Virginia Mason Medical Center, MUSC Health- Florence Medical Center, Departement of Radiation Oncology, Curie Institute, Paris, University of Michigan, MD Anderson Cancer Center, University of Alabama at Birmingham, Radiology Inc., Cedars Sinai Hospital, Roswell Park Cancer Institute, Duke University Health System, VA Hospital, DVA Medical Ctr., JFK Medical Center, Mount Sinai West, National Cancer Institute, Chung Nam National University Sejong Hospital, Indiana Univesity, AdventHealth Daytona Beach, Orlando Health, Clinical Research Institute HUS, Northwest Medical Physics Center, University of Pennsylvania, Penn Medicine, Kettering Health Network, Children's Mercy Kansas City, IBA, UMass Memorial Hospital, US Oncology, Kaiser Permanente Southern California Medical Group, The Queen's Health System, NewYork-Presbyterian, Miami Valley Hospital, Karlsruhe Institute of Technology, Piedmont Hospital, Accuray Inc., VARIAN - Advanced Oncology Solutions, GE Healthcare, Virtua Health, Northwestern Medicine Chicago Proton Center, CARO/Montgomery Cancer Center, Walter Reed National Military Medical Center, InterMountain Health Care, Englewood Hospital and Medical Center, Henry Ford Health System, Fluke Health Solutions, Texas Oncology, PA, Inova Alexandria Hospital, New Milford Hospital, Fox Chase Cancer Center, Radiation Therapy and Cancer Inst, Penn State College of Medicine, University of California San Francisco, Unity of Oncologic Therapy S.A., Canon Medical Systems USA, Kaiser Permanente, Baptist Health Paducah, Salina Regional Health, Centre d'Oncologie de la Cote Basque, Minneapolis Radiation Oncology, Coastal Carolina Radiation Oncology, Saint Francis Hospital, Advocate Christ Medical Ctr, Universidad de Costa Rica, CAMP, Blessing Hospital, Texas Oncology Cancer Ctr, CommonSpirit Health, Navy Medical Forces Atlantic, Regions Hospital, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Methodist Hospital, Champlain Valley Physicians Hospital, Mayo Clinic Jacksonville, OHSU, Promedica Health System, Arthur JE Child Comprehensive Cancer Centre, Rhode Island Hospital / Warren Alpert Medical, UPMC Pinnacle Health, Vassar Brothers Hospital, McLeod Regional Medical Center, RJ Tokarz MIRS, St. Francis Hospital, Astarita Associates, Inc., UC Davis Medical Center, Mount Nittany Medical Center, Covenant Radiation Center, National Institute of Standards and Technology, AdventHealth Orlando, St Helena Hospital, Icon Cancer Centre, University of Washington, Indiana University, TrueNorth Medical Physics LLC, Medstar Georgetown University Hospital, Harold Alfond Center for Cancer Care, MN Oncology, Jupiter Medical Center, GE HealthCare, Rochester General Hospital, Piedmont Health, Atrium Health, Minneapolis VA Health Care System, CentraCare Health System, OMPC Diagnostic LLC, Evergreen Health Medical Center, CAMC Cancer Center - Beckley, University of Kansas Medical Center, Avera McKennan, Cleveland Clinic, Louisiana Tech University

Abstract Preview: N/A...

Neural Implicit K-Space for Accelerated Patient-Specific Non-Cartesian MRI Reconstruction

Authors: Daniel O Connor, Mary Feng, Hui Lin, Hengjie Liu, Xin Miao, Michael Ohliger, Jess E. Scholey, Ke Sheng, DI Xu, Wensha Yang, Yang Yang

Affiliation: UCSF, University of California, Los Angeles, Department of Radiation Oncology, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, University of California at San Francisco, University of San Francisco, Department of Radiology, University of California, San Francisco, University of California San Francisco, Siemens Medical Solutions USA Inc.

Abstract Preview: Purpose: The scanning time for a fully sampled MRI is lengthy. Compressed sensing (CS) has been developed to minimize image artifacts in accelerated scans, but the required iterative reconstruction is...

Normal Tissue Dosimetry during Intra-Cavitary HDR Brachytherapy

Authors: Palanisamy Karunanithi, Karthikeyan Perumal, Siva Subramanian Vadivel

Affiliation: Dr. Kamakshi Memorial Hospital

Abstract Preview: Purpose:
Recent advancements in high dose-rate (HDR) brachytherapy include the image guidance, new applicators, and dose calculation algorithms. Brachytherapy has steep dose gradient, hence relativ...

Novel 3D Imaging Systems for Surgical Guidance : Loop-X and Nview S1 in Comparison with O-Arm

Authors: Jia Wang, Vani Yadav

Affiliation: Stanford University

Abstract Preview: Purpose: To evaluate the radiation dose and imaging quality of two novel CBCT X-Ray imaging systems used in spine surgeries.
Methods: CBCT scan of ACR CT and CTDI phantoms was performed to acquire ...

Novel Fast Cone-Beam CT for Adaptive Radiotherapy: Assessment of Image Distortion, Auto-Contouring, and Dose Delivery Accuracy in the Presence of Periodic Subject Motion

Authors: David P. Adam, William T. Hrinivich, Taoran Li, Alexander Lu, Michael Salerno, Alejandro Sisniega, Boon-Keng Kevin Teo

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University, University of Pennsylvania

Abstract Preview: Purpose: Cone beam CT (CBCT)-guided online adaptive radiotherapy (ART) is of growing interest, with recent improvements in image quality provided through larger detector panels and fast gantry rotatio...

Novel Use of 3D Printing for Pre-Operative Dose Estimation in the First Case of Gammatile Spine Implantation

Authors: Ali Al Asadi, Amanda Lynn DiCarlo, Anthony J. Doemer, Jessie Y. Huang, Ian Y Lee, Alexandra Moceri, Adam Robin, Lisa Scarpace, Mira Shah, Salim Siddiqui, Kundan S Thind

Affiliation: Henry Ford Innovations, Henry Ford Health

Abstract Preview: Purpose: For a patient who had two previous courses of external beam therapy for rectosigmoid adenocarcinoma and presented with painful, recurrent disease in the sacrum, this study describes the first...

On the Sensitivity Evaluation of End-to-End Test in Radiotherapy

Authors: Yussuf A. Abdelal, Sebastien A. Gros, Luke Layman, Anil Sethi

Affiliation: Stritch School of Medicine, Cardinal Bernardin Cancer Center, Loyola University Chicago, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago

Abstract Preview: Purpose:
End-to-end (E2E) test is a vital QA check of the overall radiotherapy process from simulation imaging to treatment delivery. Although clinical passing criteria are available, guidelines on...

Oncoflat: Automated 3D-to-2D Bolus Unfolding Tool for Radiation Therapy

Authors: Jeonghoon Park, Amritha Praveen, Siddhant Sen, James J. Sohn, Ethan D. Stolen

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Department of Radiation and Cellular Oncology, The University of Chicago, Department of Radiation and Cellular Oncology, University of Chicago, Department of Psychology, University of Illinois Urbana-Champaign

Abstract Preview: Purpose: Accurate fabrication of custom boluses is essential in radiation therapy to enhance dose delivery to superficial tumors, especially in anatomically complex regions. This study introduces a no...

Optimal Lattice Design for Spatially Fractionated Radiotherapy (SFRT) of Brain Metastasis in Gamma Knife (GK)

Authors: Brankica Andelic, Young-Bin Cho, Tara M. Gray, Andrew Robert Hadfield, Hakan Nordstrom

Affiliation: Elekta, Cleveland Clinic

Abstract Preview: Purpose: Spatially Fractionated Radiotherapy (SFRT) requires highly modulated dose distribution inside a tumor volume optimized using sets of planning structure of spheres in a lattice arrangement. To...

Optimization of the U-Net Model for the Radiation Dose Prediction in Lung Cancer RT Plans and Its Uncertainty Quantification

Authors: Ibtisam Almajnooni, Victor Cobilean, Milos Manic, Harindra Sandun Mavikumbure, Elisabeth Weiss, Lulin Yuan

Affiliation: Virginia Commonwealth University

Abstract Preview: Purpose: This study aims to optimize the 3D U-Net architecture for dose prediction in lung cancer radiation therapy (RT) plans, particularly in scenarios with limited clinical data, as well as to quan...

Optimization-Based Image Reconstruction Regularized with Inter-Spectral Structural Similarity for Limited-Angle Dual-Energy Cone-Beam CT

Authors: Chih-Wei Chang, Junbo Peng, Richard L.J. Qiu, Justin Roper, Xiangyang Tang, Tonghe Wang, Huiqiao Xie, Xiaofeng Yang, David Yu

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Emory Univ, Emory University, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: Limited-angle dual-energy (DE) cone-beam CT (CBCT) is considered a promising solution to achieve fast and low-dose DE imaging on current CBCT scanners without hardware modification. However, ...

Optimizing Low-Dose Imaging Parameters for Dual-Energy Cone-Beam Computed Tomography in Image-Guided Radiation Therapy

Authors: Sebastien A. Gros, Hyejoo Kang, Andrew Keeler, Luke Layman, Jason Patrick Luce, Ha Nguyen, John C. Roeske

Affiliation: Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago

Abstract Preview: Purpose:
This study aims to optimize virtual monoenergetic (VM) images obtained from dual-energy (DE) cone-beam computer tomography (CBCT) protocols for Image-Guided Radiation Therapy (IGRT). The o...

Optimizing Motion Management QA: Clinical Integration of Aapm TG-306 for the Radixact Synchrony System

Authors: Hulya Ozdemir Buss, Jeffrey Geiger, Kim Howard, Julius G. Ojwang, Neelu Soni

Affiliation: Mercy Hospital Springfield

Abstract Preview: Purpose: The Radixact Synchrony system integrates real-time motion tracking and compensates to improve treatment accuracy for moving targets. This study presents a streamlined and efficient quality as...

Para-Axial Contouring for Gynecological Brachytherapy or External Radiotherapy in Monaco

Authors: M. Victoria Duran, María Fernåndez, Inés Flores, Joaquin Hernandez, Nuria Montero, Rodrigo Plaza, Manuel Ruiz, Francisco San Miguel, Sandra Williamson Puente, Zigor Zalabarria

Affiliation: Hospital Central de la Defensa 'GĂłmez Ulla', Hospital Central de la Defensa "Gomez Ulla", CSVE, Hospital Central de la Defensa 'GĂłmez Ulla', CSVE

Abstract Preview: Purpose:
Contouring guides recommend using para-axial, para-sagittal and para-coronal axis for delimitation of ROIs. These axis are rotated from the standard axis to match the anatomy of the patien...

Patient-Specific Imaging Modality Agnostic Virtual Digital Twins Modeling Temporally Varying Digestive Motion

Authors: James M. Balter, Lando S. Bosma, Jorge Tapias Gomez, Nishant Nadkarni, Mert R Sanbuncu, William Paul Segars, Ergys D. Subashi, Neelam Tyagi, Harini Veeraraghavan

Affiliation: University of Michigan, The University of Texas MD Anderson Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Cornell University, University Medical Center Utrecht, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Develop patient-specific virtual digital twin (VDT) cohorts modeling physically realistic spatio-temporal gastrointestinal (GI) organs (stomach and duodenum) digestive motion.
Methods: Pat...

Personalized Organ Dose Estimation Using Monte Carlo Simulations, Auto-Segmentation, and Anatomical Extension from Clinical CT Scans

Authors: Belen Juste, Choonsik Lee, Matthew Mille, Rafael MirĂł, Sergio Morato Rafet, Agustin Santos, Gumersindo VerdĂș

Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Universitat PolitĂšcnica de ValĂšncia, Servicio de RadiofĂ­sica y ProtecciĂłn RadiolĂłgica, Consorcio Hospitalario Provincial de CastellĂłn, National Cancer Institute

Abstract Preview: Purpose: To evaluate the differences in CT scan radiation dose estimation between personalized dose reconstruction, based on real patient CT images, and generalized phantom-based dose calculations.

Phase One Randomized Two-Arm Dose Escalation of Flash RT in Veterinary Canine Osteosarcoma: Trial Design & Initial Results

Authors: Wesley S. Culberson, Aleksandra Ilina, Brian W Pogue, Matthew Reed, Connor Strainis, William Scott Thomas, Nathaniel Van Asselt, Albert van der Kogel

Affiliation: University of Wisconsin: Madison, University of Wisconsin: Madison School of Veterinary Medicine, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin–Madison, University of Wisconsin-Madison, University of Wisconsin - Madison

Abstract Preview: Purpose: FLASH radiotherapy reduces skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR), while preserving damage to tumor tissue. The FLASH effec...

Predicting Proton Therapy Dose Delivery Accuracy: A Machine Learning Approach Using Iroc’s Proton Phantom Data

Authors: Lian Duan, Stephen F. Kry, Hunter S. Mehrens, Paige A. Taylor

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To develop a machine learning model for predicting dose delivery accuracy and identifying its key factors in IROC’s proton phantom program.
Methods: IROC’s proton QA program has six proton...

Prior-Model-Free Dynamic CBCT Reconstruction Via Combined Optical Surface and X-Ray Imaging

Authors: Hua-Chieh Shao, Guoping Xu, You Zhang, Tingliang Zhuang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Advancements in onboard X-ray hardware allow high-quality CBCT imaging with a short scan time (~6s for Varian HyperSight), enabling CBCT-based dose calculation and treatment planning. Howe...

Proposed Method for Optimization of Lattice Radiation Therapy Using an Advanced Ring Gantry Linac

Authors: Eduardo Florian, Osmar Obdulio Hernandez, Otto Hurtarte, Milton Ixquiac, Erick Orlando Montenegro, Franky Eduardo Reyes, Edgar Aparicio Ruiz, Kevin Vega, Vicky de Falla

Affiliation: Liga Nacional Contra el Cancer, Liga Nacional Contra el Cancer/INCAN, Liga Nacional Contra el Cancer / INCAN, Liga Nacional Contra el Cancer and Universidad de San Carlos de Guatemala, Liga Nacional Contra el CĂĄncer / INCAN

Abstract Preview: Introduccion:
Lattice Radiation Therapy (LRT) is a form of spatially fractionated radiation therapy (SFRT) designed to improve control of large tumors by delivering ablative doses while minimizing ...

Prostate Dosimetric Comparison between Cyberknife and Radixact Modalities Using Precision and Raystation Planning Systems

Authors: Mireille Conrad, Cédric De Marco, Marie Fargier-Voiron, Maud Jaccard, Oscar Matzinger, Nicolas Joel Lionel Perichon

Affiliation: Clinique De Genolier

Abstract Preview: Purpose: The Accuray Synchrony real-time motion fiducial tracking solution allows for prostate stereotactic treatment on both Cyberknife and Radixact machines. In our radiotherapy department, two solu...

Quantifying the Impact of Tissue Inhomogeneities on Calculated Dosimetry within LDR Brachytherapy

Authors: Fatemeh Akbari, Deidre Batchelar, Luc Beaulieu, Nathan E. Becker, Juanita Crook, Dakota Mckeown, Matthew Jonathan Muscat, Rowan M. Thomson

Affiliation: Département de physique, de génie physique et d'optique, Université Laval, BC Cancer Agency, UBC, Carleton University, BC Cancer - Kelowna, BC Cancer

Abstract Preview: Purpose:
To study the effects of inter-seed attenuation and tissue inhomogeneities on dose-volume metrics of critical structures in prostate low-dose-rate (LDR) permanent seed implant brachytherapy...

Radiation Dose Monitoring Systems: Technology and Setup

Authors: Robert SĂĄnchez Casanueva

Affiliation: Servicio de Física Médica. Hospital Clínico San Carlos

Abstract Preview: N/A...

Radiomics Changes in MR Images of Prostate and Dominant Intra-Prostate Lesions during SBRT on MR-Linac

Authors: David L. Barbee, David Byun, Ting Chen, Paulina E. Galavis, Siming Lu, Sarah Rosemary Morris, Hesheng Wang, Michael J Zelefsky

Affiliation: NYU Langone Health

Abstract Preview: Purpose: MR-Linac enables dose escalation in prostate SBRT on accurately defined dominant intra-prostate lesion (DIL) on daily MR images. This study aims to evaluate inter-fraction changes in the radi...

Rapid CBCT Imaging with Ultra-Sparse X-Ray Projections for Head & Neck Cancer Radiotherapy

Authors: Hania A. Al-Hallaq, Chih-Wei Chang, Anees H. Dhabaan, Yuan Gao, Shaoyan Pan, Junbo Peng, Richard L.J. Qiu, Keyur Shah, Sibo Tian, Zhen Tian, Xiaofeng Yang, David Yu, Jun Zhou

Affiliation: Emory University, Whinship Cancer Institute, Emory University, University of Chicago, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: Traditional cone-beam computed tomography (CBCT) often requires multiple angular projections, increasing radiation exposure and extending scanning times, which may lead to heightened patient ...

Real Time Monte Carlo Dose Calculation for Clinical Cyberknife Radiation Therapy Based on Deep Learning Diffusion Model

Authors: Ruiyan Du, He Huang, Mingzhu Li, Ying Li, Hongyu Lin, Wei Liu, Shihuan Qin, Yiming Ren, Hui Xu, Lian Zhang, Xiao Zhang, Zunhao Zhang

Affiliation: Department of Radiation Oncology, Mayo Clinic, Medical AI Lab, The First Hospital of Hebei Medical University, Hebei Provincial Engineering Research Center for AI-Based Cancer Treatment Decision-Making, The First Hospital of Hebei Medical University, Department of Oncology, The First Hospital of Hebei Medical University

Abstract Preview: Purpose: Monte Carlo (MC) dose calculation is the gold standard in clinical CyberKnife radiation therapy (RT), considering its steep dose gradients and high-freedom non-coplanar beam angles, but extre...

Real-Time Fully Automated IMRT Planning without Optimization Process Using a Two-Step AI Framework

Authors: Daisuke Kawahara, Takaaki Matsuura, Yuji Murakami, Ryunosuke Yanagida

Affiliation: Hiroshima High-Precision Radiotherapy Cancer Center, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima

Abstract Preview: Purpose: In recent years, automation in radiation therapy planning using AI has gained significant attention to reduce the workload of treatment planners. Adaptive Radiation Therapy (ART), as a new fo...

Real-Time Proton and Carbon Ion Monte Carlo Dose Calculation through GPU-Acceleration and DL-Based Denoising Algorithms

Authors: Yankui Chang, Shijun Li, Xi Pei, Ripeng Wang, Xuanhe Wang, X. George Xu, Qing Zhang, Jingfang Zhao

Affiliation: University of Science and Technology of China, Shanghai proton and heavy ion center, School of Nuclear Science and Technology, University of Science and Technology of China, Anhui Wisdom Technology Co., Ltd.

Abstract Preview: Purpose:
This paper describes disruptive methods using both GPU-based MC simulation and deep-learning (DL)-based MC denoising algorithms, as well as clinical tests involving more than 560 patient p...

Rectangular Aperture-Based Beam Orientation Optimization for 4π Non-Coplanar Small Animal IMRT Delivery

Authors: Dante PI Capaldi, Lu Jiang, Qihui Lyu, Ke Sheng

Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose:
Preclinical small animal studies help understand radiation-induced biological responses, toxicities, and mechanisms, facilitating the translation of new therapies to patient treatment. Int...

Reducing Distal-Edge Toxicity in Breast Proton Therapy Via LETd and Track-End Optimization

Authors: Matthew Case, Richard Castillo, Sunil Dutta, Edgar Gelover, Katja M. Langen, Alexander Stanforth, Mingyao Zhu

Affiliation: Emory University

Abstract Preview: Purpose: To evaluate the application of LETd and track-end (TE) objective functions during the optimization of breast proton therapy plans to decrease the risk of lung toxicity and rib fractures.
M...

Retrospective Evaluation of Combined Photon SBRT and Radium-223 SPECT Based Radiopharmaceutical Therapy Tumor Dosimetry in Clinical Trial Patient Cases

Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang

Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill

Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...

Retrospective Study Using Avi Planner for Head and Neck Cancer Cases: Our Experience at Nsia-Luth Cancer Center, South - West Nigeria

Authors: Adebayo Abe, Samuel Olaolu Adeneye, Eben Aje, Bidemi I. Akinlade, Inioluwa Damilola Ariyo, Lilian Ekpo, Muhammad Habeebu, Adedayo O. Joseph, Charles S. Mayo, Noah Ndianaobong, Ikechi S Ozoemelam, Margaret Dideolu Taiwo, Godwin Uwagba

Affiliation: University of Michigan, University of Ibadan, University of Lagos, Missouri University of Science and Technology, NSIA-LUTH Cancer Center, University of Lagos, NSIA-LUTH Cancer Centre, NSIA-LUTH Cancer Center

Abstract Preview: Purpose:
Head and neck cancers (HNC) present significant challenges in radiotherapy due to complex anatomy and the proximity to critical organs at risk (OARs). These challenges are compounded in na...

Robust Evaluation of Rotational Uncertainties on Single-Isocenter Multi-Target Stereotactic Radiosurgery Hyperarc Treatment

Authors: Albert Admasu, Kayla Alfonso, Maria de la Luz De Ornelas, Nesrin Dogan, Eric Mellon, Yunze Yang

Affiliation: University of Miami, Department of Radiation Oncology, University of Miami, University of Miami Sylvester Comprehensive Cancer Center

Abstract Preview: Purpose: Rotational uncertainties in single-isocenter multi-target (SIMT) stereotactic radiosurgery (SRS) HyperArc treatments can cause additional target displacement, potentially degrading overall pl...

Robust and Radiobiologically Accurate Dose Summation Strategy for Multiple Courses of Stereotactic Re-Irradiation of Metastatic Brain Cancer Patients with Previous WBRT

Authors: Garrett Russell Hamilton, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Recurrent brain metastasis is very common, and patients who previously received whole-brain radiotherapy (WBRT) may receive an additional course(s) of stereotactic radiosurgery (SRS) to selec...

Secondary Neutron Dosimetry of Cieds Exposed to Neutron-Producing Photon Radiation Therapy

Authors: Angela Gearhardt, Stephen F. Kry, Christopher Ryan Peeler, Julianne M. Pollard-Larkin

Affiliation: The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: A growing number of radiation therapy (RT) patients have cardiovascular implantable electronic devices (CIEDs). Patients with CIEDs must be carefully managed because the devices are susceptib...

Sensitivity of CT Ventilation Imaging to Image Acquisition and Reconstruction Parameters: A Phantom Study

Authors: Hilary Louisa Byrne, Paul J. Keall, John Kipritidis, Jeremy Lim

Affiliation: Northern Sydney Cancer Centre, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney

Abstract Preview: Purpose:
Non-contrast CT ventilation imaging (CTVI) has been developed as a cost-effective and accessible alternative to PET/SPECT V/Q imaging for visualizing lung function. However, the sensitivit...

Standardized Immobilization and Setup Procedure Improves Accuracy of Multi-Time Point SPECT/CT Image Registration for Radiopharmaceutical Therapy (RPT) Dosimetry

Authors: Bryan Bednarz, Laura Bennett, Abby E. Besemer, Tyler J Bradshaw, Steve Y Cho, John M. Floberg, Joseph Grudzinski, Elissa Khoudary, Michael J. Lawless

Affiliation: Department of Radiology, University of Wisconsin, University of Wisconsin-Madison Department of Medical Physics, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Voximetry, Inc, University of Pennsylvania, Department of Radiology, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: To assess the impact of using a standardized immobilization setup for multi-time-point SPECT/CT imaging on radiopharmaceutical therapy (RPT) dosimetry image registration.

Methods: Ten ...

Stereotactic Body Radiosurgery for Refractory Ventricular Tachycardia: Presenting Efficient Clinic Workflow, Dosimetric Analysis and Patients Reported Clinical Results

Authors: Karam Ayoub, Aaron B Hesselson, Ronald C McGarry, Joshua Misa, Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Department of Cardiology

Abstract Preview: Purpose: Noninvasive stereotactic body radiosurgery (SBRS) is emerging treatment option for advanced heart failure patients with refractory-ventricular tachycardia (rVT) who experienced recurrent impl...

Streamlined Calibration of Mosfet Dosimeters for Radixact Systems: Addressing Angular Dependence and Beam Profile Challenges

Authors: Guang-Pei Chen, Renae Conlin, Juan A. Garcia-Alvarez, Kirk Morris, Haidy G. Nasief, Eenas A. Omari, Eric S. Paulson

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Cumulative dose limits make replacing and calibrating Metal Oxide Semiconductor Field Effect dosimeters (MOSFET-d) used for in-vivo dosimetry a common clinical task. Calibration protocols for...

Targeted Multi-Criteria Optimization for Rapid Improvement of Organ-at-Risk Dose in the Setting of Prostate Stereotactic Body Radiation Therapy

Authors: Alyssa Gadsby, William J. Godwin, Daniel G. McDonald, Jean L. Peng, Alek K. Rapchak, Sean A Roles, Austin M. Skinner, Stephanie Tan

Affiliation: Medical University of South Carolina

Abstract Preview: Purpose: To utilize multi-criteria optimization (MCO) in a targeted fashion to quickly and easily improve dose to the rectum when treating the prostate with stereotactic body radiation therapy (SBRT)....

Temporal Drift in Ir-192 Source Strength Measurements: A Braphyqs Multi-Center Analysis

Authors: Åsa K. Carlsson Tedgren, Taran Hellebust, Antonio Herreros, Jacob Johansen, Christian Kirisits, Panagiotis Papagiannis, Mark J. Rivard, Frank-Andre Siebert, Frank Verhaegen, Javier Vijande, Jan Wiersma, Marisol de Brabandere, Ruud van Leeuwen

Affiliation: UKSH, Campus Kiel, Klinik fĂŒr Strahlentherapie (Radioonkologie), Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Radiation Physics, Department of Medicine and Health (IMH), Linköping University, Radiation Oncology Department, Hospital ClĂ­nic-Universitat de Barcelona, IDIBAPS, IFIC-UV, Radiation Oncology, Amsterdam UMC location University of Amsterdam, Department of Radiation Oncology, Radboud University Medical Center, Department of Oncology, Aarhus University Hospital, University Hospital Gasthuisberg, Dept. of Radiation Oncology, Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Reproduction, Maastricht University Medical Centre+, Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Warren Alpert Medical School of Brown University

Abstract Preview: Purpose: This study, which was carried out by the GEC-ESTRO BRAPHYQS working group, reports the increasing divergence between clinical reference air kerma rate (RAKR) measurements and vendor-provided ...

Testing the Performance of Rbe Models Using a Comprehensive Panel of Pancreatic Cancer Cell Lines

Authors: Joana Antunes, Scott James Bright, David B. Flint, Mojtaba Hoseini-Ghahfarokhi, Mandira Manandhar, Poliana Marinello, Gabriel O. Sawakuchi, Tingshi Su

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Laboratory of Instrumentation and Experimental Particle Physics; Faculty of Science of University of Lisbon, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, MD Anderson Cancer Center

Abstract Preview: Purpose: To study the accuracy of relative biological effectiveness (RBE) models to predict the RBE of a comprehensive panel of pancreatic cancer cell lines.

Methods: Clonogenic cell survival w...

The Development of Large Field MR Guided Radiotherapy for Pelvic Lymph Node SBRT and Its Dosimetry Improvement

Authors: David Byun, Ting Chen, Paulina E. Galavis, Allison McCarthy, Hesheng Wang, Michael J Zelefsky

Affiliation: NYU Langone Health

Abstract Preview: Purpose: To summarize a MR guided adaptive workflow developed for pelvic lymph nodes (PLN) stereotactic radiotherapy using large field size on Elekta Unity© MR Linac system, and to quantitatively anal...

The Dosimetric Impact of the Incremental Discontinuation of Bolus during Postmastectomy Chest Wall Radiation Treatment for Breast Cancer.

Authors: Anthony R Bardwell, Dong Won Kim, Faith S Kim, Isaac Y Kim, Juying Zhang

Affiliation: Kaiser Permanente

Abstract Preview: Purpose: When a patient develops a significant skin reaction at some point during postmastectomy radiotherapy, a clinical decision is often made to discontinue the planned daily use of bolus. The aim ...

The Effect of 2D Antiscatter Grid-Based CBCT on Tissue Visualization in the Prostate Region: An Observer Study on Tissue Delineation Accuracy

Authors: Cem Altunbas, Adam Avant, Farhang Bayat, Roy Bliley, Ian Boor, Brian Kavanagh, Uttam Pyakurel, Tyler Robin, Ryan Sabounchi

Affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Taussig Cancer Center, Cleveland Clinic

Abstract Preview: Purpose: Improved soft tissue visualization plays an important role in target localization and treatment plan adaptation in CBCT-guided radiotherapy. In this work, a novel CBCT approach, 2D antiscatte...

The Topas Monte Carlo Framework – Status and Outlook after 15 Years of Development

Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Thongchai Masilela, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin

Affiliation: University of California San Francisco, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital

Abstract Preview: Purpose: To present the results of 15 years of developments of the TOPAS TOol for PArticle Simulation framework, and to highlight recent and new developments.

Methods: Fundamental understanding...

Time and Energy-Encoded CT Reconstruction

Authors: Shusen Jing, Qihui Lyu, Dan Ruan, Ke Sheng, Qifan Xu

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Conventional computed tomography (CT) measures the collective attenuation of primary photon fluence and then reconstructs the 3D images without using the timing information of individual phot...

Total Body Irradiation Using Field-in-Field Treatment Planning Techniques

Authors: Kazi Towmim Afrin, Imad M. Ali, Jordan West

Affiliation: University of Oklahoma Health Sciences Center, University of Oklahoma

Abstract Preview: Purpose: To simulate total-body-irradiation (TBI) with field-in-field treatment planning techniques and test portal dosimetry for dose verification and quality assurance.
Methods: CT images of full...

Towards Real-Time Marker-Less Prostate Tracking on Standard Radiation Therapy Systems

Authors: Freeman Jin, Paul J. Keall, Alistair MacDonald, Adam Mylonas, Chandrima Sengupta

Affiliation: Image X Institute, Faculty of Medicine and Health, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney, Image X Institute, School of Health Sciences, University of Sydney

Abstract Preview: Purpose: During radiation therapy, tumours in the prostate may move from the planned treatment position, leading to significant dose deviations above clinical tolerances Surveys have indicated the nee...

Tumor Density on Time-Weighted Mid-Position Images for Thoracic Tumors

Authors: Katrinus Keijnemans, Eric S. Paulson, An Tai

Affiliation: Department of Radiotherapy, University Medical Center Utrecht, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Time-weighted mid-position images (MidPs), derived from four-dimensional computed tomography (4DCT) via deformable image registration (DIR), are frequently selected for treatment planning due...

Two-Stage Clustering and Auto Machine Learning to Predict Chemoradiation Response in Tumor Subregions on FDG PET for La-NSCLC

Authors: Stephen R. Bowen, Shijun Chen, Chunyan Duan, Daniel S. Hippe, Qiantuo Liu, Qianqian Tong, Jiajie Wang, Shouyi Wang, Faisal Yaseen

Affiliation: The University of Texas at Austin, Tongji University, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Fred Hutchinson Cancer Center, University of Texas at Arlington

Abstract Preview: Purpose: Tumor subregion clustering and prediction of region-specific response can augment assessments and adaptive treatment decisions. A modeling framework was constructed to predict chemoradiation ...

Ukan Architecture for Voxel-Level Dose Prediction in Radiotherapy

Authors: Lu Jiang, Ke Sheng

Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose:
Conventional radiotherapy treatment planning is guided by a set of generic objectives that are unspecific to patient anatomy. Treatment planning thus heavily relies on the planner’s experi...

Ultra-Fast Commissioning and Quality Assurance with Plastic Scintillation Detector

Authors: Saad Bin Saeed Ahmed, Marcos Feijoo, Wazir Muhammad, Charles Shang, Naseem Ud Din

Affiliation: South Florida Proton Therapy Institute, Miami Cancer Institute, Blue Physics LLC, Florida Atlantic University

Abstract Preview: Purpose: Accurate, efficient, and reliable commissioning of linear accelerator (LINAC) is critical for ensuring high-quality radiation therapy treatments. The study uses advanced detector technology a...

Ultrafast Proton Delivery with Pin Ridge Filters (pRFs): A Novel Approach for Motion Management in Proton Therapy

Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Yinan Wang, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou

Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: Active breath-hold techniques effectively mitigate respiratory motion but poses challenges for patients who are unable to tolerate the procedure. Conventional planning relies on multiple ener...

Uncertainties on Synthetic-CT Generation from CBCT: Another Layer of Complexity in Abdominal Adaptive Radiotherapy

Authors: Laura I. Cervino, Wendy B. Harris, Paulo Quintero, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To evaluate the impact of the prediction uncertainty from CBCT-based synthetic CT (sCT) generation in abdominal adaptive radiotherapy.

Methods: CT and CBCT images from 65 abdominal pat...

Uncertainty Analysis for Effective Dose Conversion Factors in CT

Authors: Renxin Chu, Jelena Mihailovic, Kai Yang, Lifeng Yu, Da Zhang

Affiliation: Massachusetts General Hospital, Mayo Clinic, Boston Children's Hospital, UVA Health University Hospital, University of Missouri Health Care

Abstract Preview: Purpose:
A frequently used method to estimate effective dose (ED) in CT is by multiplying the dose length product (DLP) by a conversion factor, known as k-factor. The k-factor in this method is sus...

Universal MR-to-Synthetic CT: A Streamlined Framework for MR-Only Radiotherapy Planning

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Converting MR images to synthetic CT (MR2sCT) is highly desirable as it streamlines the radiotherapy treatment planning workflow. This approach leverages the superior soft tissue visibilit...

Using Multiple Sequences MRI for Synthesizing CT Based on a Deep Learning Approach

Authors: Jie Hu, Nan Li, Chuanbin Xie, Shouping Xu, Xinlei Xu, Gaolong Zhang, Zhilei Zhang

Affiliation: School of Physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Radiation Oncology, the First Medical Center of the People's Liberation Army General Hospital, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PeopleÊŒs Republic of China, Department of Radiation Oncology, School of Physics, Beihang University, Beijing, 102206, PeopleÊŒs Republic of China

Abstract Preview: Purpose: This study aims to synthesize CT images for MRI-only radiation therapy using a deep learning approach that integrates information from the T1- and T2-weighted MRI sequence.
Methods: 97 hea...

Using Varian’s Obi Tools to Develop a CBCT Workflow with Triggered Imaging for Spine SBRT Intrafraction Motion Monitoring

Authors: Yi An, David J. Carlson, Zhe (Jay) Chen, Jun Deng, Dae Yup Han, Sameer Taneja

Affiliation: Yale School of Medicine, Yale University School of Medicine, Department of Therapeutic Radiology, Yale University School of Medicine

Abstract Preview: Purpose: Spine Stereotactic radiosurgery (SSR) delivers a large radiation dose and utilizes narrow PTV margins, on the order of 1 mm, to avoid excess dose to the spinal cord. Because of this, intrafra...

Using a-Si 1200 Epid Portal Dosimetry for VMAT Commissioning

Authors: Ryan Burri, Nazanin Hoshyar, Jerry W. McCoy, Yulin Song, Huma Syed

Affiliation: Bay Pines VA Medical Center

Abstract Preview: Purpose: The study aimed to streamline traditionally manual, iterative, and time-consuming VMAT commissioning process. The goal was to identify an optimal set of MLC dosimetric parameters that minimiz...

Utilization of Log File Analysis to Determine Deliverability of VMAT Plans As a Function of Plan Complexity

Authors: Jameson T. Baker, Sean T Grace, Cindy Pham, Michael A. Trager

Affiliation: Northwell

Abstract Preview: Purpose:
In VMAT planning, increasing complexity in MLC motion and modulation may improve dose distributions and OAR sparing while maintaining PTV coverage. However, increasing complexity can creat...

Validating a Pre-Existing CT HU-to-Mass Density Curve for Direct Dose Calculation on High Quality Cbcts

Authors: Casey E. Bojechko, Tricia Chinnery, Grace Gwe-Ya Kim, Xenia Ray

Affiliation: University of California San Diego

Abstract Preview: Purpose: To evaluate the use of a calibration curve generated from the CT simulator for direct dose calculation on cone beam computed tomography (CBCT) images taken with the on-board imaging system. T...

Validation and Benchmarking of Mirdct Software for Organ Dose Estimation in Routine CT Protocols

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Gunjan Kayal, Adam Leon Kesner, Harry Marquis, Juan Camilo Ocampo Ramos, Stefan Wehmeier

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: Accurate organ dose estimation in computed tomography (CT) has gained attention due to the increasing global utilization of CT imaging. MIRDct, a specialized CT dosimetry software, has recent...

Voxel-Dose Implications of Single-Compartment Dosimetry for Ablative 90Y-Radioembolization Segmentectomy

Authors: Srinivas Cheenu Kappadath, Benjamin P. Lopez, Armeen Mahvash

Affiliation: UT MD Anderson Cancer Center

Abstract Preview: Purpose: 90Y-radioembolization is utilized with curative intent. While single-compartment doses to the perfused volume for the complete pathologic necrosis (CPN) of tumors have been reported, the actu...

Water-Equivalent Thickness Mapping (WET-MAP) – a Potential Alternative to 4D Robust Optimization for Motion Management in Proton Treatment Planning

Authors: Duncan Henry Bohannon, Pretesh Patel, Sibo Tian, Yinan Wang, Xiaofeng Yang, Ahmal Jawad Zafar, Jun Zhou

Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose:
4D robust optimization, incorporating additional images (e.g., maximum inhale/exhale phases), is commonly used to account for target motion in proton treatment planning. However, the incre...

Weakly Supervised Spatial Implicit Neural Representation Learning for 3D MRI-Ultrasound Deformable Image Registration in HDR Prostate Brachytherapy

Authors: Michael Baine, Yang Lei, Yu Lei, Ruirui Liu, Tian Liu, Jing Wang

Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center

Abstract Preview: Purpose: Accurate 3D deformable registration of MRI and ultrasound (US) is essential for real-time image guidance during high-dose-rate (HDR) prostate brachytherapy. However, MRI-US registration of th...

X-Ray Motion Tomography: Creating 3D Lung Motion from Sparse 2D X-Ray Projections

Authors: Hilary Louisa Byrne, Owen Thomas Dillon, Paul J. Keall, Hunor Kertesz, Ricky O'Brien, Tess Reynolds

Affiliation: University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney, Medical Radiations, School of Health and Biomedical Sciences, RMIT University

Abstract Preview: Purpose: Imaging of lung motion and function has typically required multiple volumetric CT images to create deformation vector fields (DVF) for motion and ventilation images (function). However, CT sc...