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Results for "William St Clair": 10 found

A Novel Sphere Packing Solution Via Principal Component Analysis for Lattice SFRT Treatment of Large, Bulky, and Unresectable Tumors

Authors: James Robert Castle, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: We propose a novel methodology for lattice deployment in spatially fractionated radiotherapy (SFRT), using principal component analysis (PCA) to improve sphere packing within the tumor. Impro...

Automated Treatment Planning for Linac-Based Stereotactic Radiosurgery of Intraocular Malignancies Via Hyperarc Knowledge-Based Planning

Authors: Chase Cochran, Shane McCarthy, Damodar Pokhrel, William St Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Manually generating intraocular stereotactic radiosurgery (SRS) plans involves significant challenges, including lengthy planning times and inter-planner variability. Knowledge-based SRS plan...

Automated Treatment Planning for Stereotactic Recurrent Head and Neck Cancers Using Knowledge-Based Planning, Multicriteria Optimization, and Dosimetric Scorecards

Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Demonstration of automated stereotactic treatment planning for recurrent head and neck (RHN) cancers using knowledge-based planning, multicriteria optimization (MCO), and dosimetric scorecard...

Clinical Outcomes of Gamma Knife Stereotactic Radiosurgery Treatments for Intracranial Arteriovenous Malformations & Fistulas: A Single Institutional Retrospective Study

Authors: Madeleine Arbogast, David Dorndos, Denise E Foltz, Justin Fraser, Damodar Pokhrel, William St Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Department of Neurosurgery, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: For stereotactic radiosurgery (SRS) treatments of intracranial arteriovenous malformations (AVM) and fistulas (AVF), same-day Leksell Gamma Knife (GK) is the preferred modality. Long-term cli...

Clinical Validation of a Deep-Learning Segmentation Tool for Head and Neck Cancer Patients and Thoracic and Abdominal Cancer Patients

Authors: Haijian Chen, Katja M. Langen, William Andrew LePain, Claire Tran, Mingyao Zhu

Affiliation: Emory Healthcare, Emory University, Georgia Institute of Technology

Abstract Preview: Purpose: To validate the performance of a commercial deep-learning segmentation (DLS) tool for head and neck cancer (HNC) and thoracic and abdominal cancer (TAC) by comparing it to manual segmentation...

Development and Clinical Validation of Hyperarc Stereotactic Radiosurgery Method for Intraocular Tumors

Authors: Chase Cochran, Damodar Pokhrel, William St Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Currently, intraocular disease is primarily treated via COMS-plaques brachytherapy. Various stereotactic approaches via photons/proton beam have also been implemented (CyberKnife/GammaKnife/p...

Differential Hole-Size Lattice Patterns for Escalating SFRT Dose to Large, Deep-Seated, and Unresectable Masses

Authors: Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumor’s center, surrounded by smaller diameter spheres. W...

Presenting a Novel Treatment Scheme for Debulking Unresectable Large Tumors: Feasibility, Safety and Patient Reported Early Clinical Outcomes of SBRT Immediately Post-Spatially Fractionated Radiotherapy Delivery

Authors: James Knight II, Joshua Misa, Damodar Pokhrel, William St Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Highly-heterogenous sieve-like dose distribution via SFRT to large/bulky tumors (≥6 cm) could enhance tumor cell-death via both direct/indirect cell-kill mechanisms. Adding highly-conformal S...

Robust and Radiobiologically Accurate Dose Summation Strategy for Multiple Courses of Stereotactic Re-Irradiation of Metastatic Brain Cancer Patients with Previous WBRT

Authors: Garrett Russell Hamilton, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Recurrent brain metastasis is very common, and patients who previously received whole-brain radiotherapy (WBRT) may receive an additional course(s) of stereotactic radiosurgery (SRS) to selec...

Tumor Dose Escalation for Recurrent Head and Neck SRT Via a Hyperarc-Based Rapidplan Model

Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Demonstrating the feasibility of dose escalation for stereotactic recurrent head and neck (RHN) cancers through the deployment of a Hyper-Arc Based RapidPlan (HARP) model through an Eclipse S...