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Results for "absorbed doses": 49 found

A Dosimetric Analysis of Lu-177-Based Radiopharmaceutical Therapy for Optimizing Therapeutic Ratio

Authors: Travis James McCaw, Ravi Patel, Abdelhamid Saoudi, Joseph Shields

Affiliation: UPMC Hillman Cancer Center, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, UPMC

Abstract Preview: Purpose: The current treatment approach for Lu-177-based radiopharmaceutical therapy involves multiple administrations, each delivering a constant activity of 200 mCi. This study evaluates whether the...

A Monte Carlo Dosimetry-Based Cell Survival Model Incorporating Spatial and Temporal Heterogeneity for Rpt Preclinical Studies

Authors: Alejandro Bertolet, Michael D. Farwell, Sarah Gitto, Victor V. Onecha, Daniel Pryma, Aladdin Riad

Affiliation: Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Department of Radiology, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: Responses to ionizing radiation (IR) strongly correlate with the absorbed dose. At the cellular level, this is typically described by a linear-quadratic relationship provided the cell populat...

A Novel Integrated Framework for Rapid Automatic Calculation of Organ Absorbed Dose from kV-CBCT Imaging during Radiotherapy

Authors: Marios Myronakis, Kyriaki Theodorou

Affiliation: Medical Physics Department, Medical School, University of Thessaly

Abstract Preview: Purpose: The development of an integrated application framework for rapid, seamless, and automated calculation of absorbed organ dose for individual patients undergoing kV CBCT imaging over the course...

A Practical Experimental Software Validation Method for Voxel-Based Personalised Dosimetry in Radiopharmaceutical Therapy

Authors: Thomas Gee, Sofia Michopoulou, Amit Nautiyal

Affiliation: University Hospital Southampton

Abstract Preview: Purpose: Dosimetry software that is accessible to departments offers new opportunities to improve patient-specific dosimetry. Prior to clinical decision-making, it is essential to validate dosimetry s...

A Refined Model of Reference Mesh-Type Female Breast Model Vasculature and Glandular Structures for Internal Circulating Lymphocyte Dosimetry

Authors: Wesley E. Bolch, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Lazaro Fuentes Alfonso, Shreya P. Pathak, Julia D. Withrow

Affiliation: University of Florida

Abstract Preview: Purpose: To develop tetrahedral mesh-based tissue models within the breasts of the International Commission on Radiological Protection (ICRP) adult female mesh-type reference computational phantom (AF...

An Alpha Irradiation System for Radiobiological Studies with Versatile Dose Rate Control

Authors: Harsh Arya, Yan Chang, Yujie Chi, Varghese Anto Chirayath, Joshua Rajan, Pan Zui

Affiliation: University of Texas at Arlington, Department of Physics, University of Texas at Arlington

Abstract Preview: Purpose: In targeted alpha therapy (TAT), absorbed dose rates can vary significantly spatially and temporally, impacting therapeutic efficacy as well as carcinogenic potential. This study reports the ...

An Experimentally Derived Microscale Blood and Lymphatic Vasculature Model for Applications to Radiopharmaceutical Dosimetry

Authors: Peter Balogh, Wesley E. Bolch, Mir Md Nasim Hossain, Nien-Wen Hu, Walter Murfee, Wyatt Smither, Julia D. Withrow

Affiliation: New Jersey Institute of Technology, University of Florida

Abstract Preview: Purpose: To develop 3D computational, tissue-representative models incorporating physiologically relevant microvascular network patterns for calculating local alpha particle and electron dosimetry eff...

Assessing Long-Term Stability of Parylene-Coated, 3D-Printed Plastic Vessels for Water Calorimetry-Based Radiation Dosimetry

Authors: Philip Cutter, Mark D'Souza, Arman Sarfehnia

Affiliation: Toronto Metropolitan University, Sunnybrook Health Sciences Centre, Sunnybrook Health Science Center

Abstract Preview: Purpose: Water calorimetry (WC) serves as an important standard for measuring absorbed dose to water, an essential metric in radiation therapy. WC directly and absolutely quantifies energy deposition ...

BEST IN PHYSICS IMAGING: Dosimetric Impact of Iodinated Contrast Agent on Fibroglandular Tissue in Contrast-Enhanced Digital Mammography

Authors: Hannah Grover, Andrew J. Sampson

Affiliation: Oregon Health & Science University, UT Health San Antonio

Abstract Preview: Purpose: The goal of this work was to quantify the dosimetric impact of iodinated contrast on fibroglandular breast tissue to better inform clinical risk and benefit assessments when determining the m...

Biokinetic Modeling and Dosimetry of Radiopharmaceutical Extravasation in Lu-177-PSMA Therapy for Metastatic Castration-Resistant Prostate Cancer

Authors: Shaheen Dewji, Emmanuel Mate-Kole, Sergio F Ruiz, Chris C. Wang

Affiliation: Georgia Institute of Technology, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology

Abstract Preview: Purpose: Extravasations are clinical events when a substance is administered intravenously and the fluid starts to leak into surrounding tissue instead of the target vessel. In the case of radiopharma...

Calorimetric Measurement of Absorbed Dose By a Flash Beamline

Authors: Luke Connell, Stephen F. Kry, Malcolm R. McEwen, Bryan R. Muir, James Renaud, Emil Schueler, Hayden Scott, Paige A. Taylor

Affiliation: National Research Council, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: To demonstrate the capability of a robust calorimeter to accurately determine the absorbed dose delivered by an electron FLASH beamline.

Methods: Electron FLASH beams of 6 MeV and 9 Me...

Commissioning, Validation and Pilot Study of New Rpld System for Dosimetry Audits in Bulgaria

Authors: Gueorgui Gueorguiev, Katia Sergieva, Filip Simeonov, Tsvetelina Todorova, Bozhidar Vladimirov

Affiliation: National Centre of Radiobiology and Radiation Protection, Queen Giovanna University Hospital

Abstract Preview: Purpose: Dosimetry audit is an essential tool enhancing confidence in the accuracy of treatment delivery and in prevention of radiation treatment incidents. Current work depicts how novel nationwide r...

Computed Tomography Organ Dose Library Derived from Newly Developed Newborn-Infant-Toddler Computational Phantoms

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Adam Leon Kesner, Cameron B. Kofler, Juan Camilo Ocampo Ramos, Yitian Wang, Stefan Wehmeier

Affiliation: University of Chicago, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: To develop a slice-specific computed tomography (CT) organ dose library using Monte Carlo radiation transport simulations on a newly created set of newborn, infant, and toddler computational ...

Deployable Twin-Calorimeter System for Absolute Dose Measurements By Clinical Physicists

Authors: Jean Dessureault, Malcolm R. McEwen, Bryan R. Muir, James Renaud

Affiliation: National Research Council

Abstract Preview: Purpose: To develop and commission a mailable calorimeter that enables clinical medical physicists to quickly and efficiently address innovative dosimetry challenges directly at the point of use.
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Development of Cross-Platform Application for Radiation Contamination Assessment

Authors: Wesley E. Bolch, Lotem Buchbinder Shadur, Natalia Estefania Carrasco-Rojas, Chansoo Choi, Robert Joseph Dawson, Shaheen Dewji, John Francis, Emmanual Mate-Kole, Wyatt Smither, Yitian Wang

Affiliation: Georgia Tech, University of Florida, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology

Abstract Preview: Purpose: Develop a software application capable of assessing the radiation contamination of military service members and members of the general public for fast, on-site radiological triage. The softwa...

Development of Preclinical Multiscale Dosimetry for Beta-Particle Emitting Radionuclide in Radiopharmaceutical Therapy

Authors: Adedamola Adeniyi, Bryan Bednarz, Malick Bio Idrissou, Reinier Hernandez, Ohyun Kwon, Brian W. Miller, Zachary S Morris, Maya Takashima, Jamey Weichert

Affiliation: Departments of Radiation Oncology and Medical Imaging, University of Arizona, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Radiology, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin–Madison

Abstract Preview: Purpose: As radiopharmaceutical therapy (RPT) becomes more prevalent in clinical applications, understanding dose-response relationships in the tumor microenvironment (TME) and normal tissues is essen...

Development of a Bayesian Network for a Comprehensive Uncertainty Assessment in Personalized Dosimetry after Targeted Radionuclide Therapy

Authors: NadÚge Anizan, David Broggio, Eric Chojnacki, Estelle Davesne, Didier Franck, Stéphanie Lamart, Alexandre Pignard

Affiliation: Institut Bergonié, Service de Physique Médicale, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSE-SANTE/SDOS, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSN-RES/SEMIA/LSMA

Abstract Preview: Purpose: To develop an innovative method enabling a comprehensive uncertainty budget associated to personalized absorbed doses for 177Lu-PSMA therapy and providing probability distributions of all dos...

Dosimetric Comparison & Error Analysis of Aapm TG51 & WGTG51-e Protocol with Icru-90 Key-Data for High-Energy Clinical Electron Beam

Authors: Amar K. Basavatia, Sandeepan Ganguly, Lee C. Goddard, Wolfgang A. Tomé

Affiliation: Montefiore Medical Center

Abstract Preview: Purpose: To investigate the dosimetric impact of WGTG51-e Report 385, recently updated CoP for clinical electron beams. This study uses a chamber specific effective point of measurement (EPOM) shift t...

EBT4 Film Dosimetry and the Significance of the Œ Fwhm Rule for Gamma Knife Output Factors

Authors: Jingying Lin, Stevan Pecic, Strahinja Stojadinovic

Affiliation: University of Belgrade, The University of Texas Southwestern Medical Center

Abstract Preview: Purpose: This study aims to determine the magnitude of polarization-induced dosimetric error for EBT4 films at different scanning orientations, and to provide guidance on selecting appropriate regions...

Evaluating 177Lu-PSMA-I&t Reconstruction Parameter Influences on Image Quality and Quantification

Authors: Martin Auerbach, Jeremie Calais, Johannes Czernin, Magnus Dahlbom, Zachary Ells, Adrien Holzgreve, Koichiro Kimura, Karam Masri, Catherine (Caffi) Meyer, David Sennung

Affiliation: Department of Nuclear Medicine, UCLA, UCLA, University of California, Los Angeles

Abstract Preview: Purpose: Lutetium-177 PSMA SPECT/CT imaging offers the possibility of qualitative image analysis for tumor response assessment and quantitative image analysis for individualized dosimetry. However, th...

Evaluating DNA Damage Efficacy for 90y and 225ac Based Radiotherapy

Authors: Ramin Abolfath, Alejandro Bertolet, Kofi M. Deh, Rao Khan, Vanessa Sanders, Daniel Suarez-Garcia

Affiliation: Massachusetts General Hospital and Harvard Medical School, University of Sevilla, Brookhaven National Laboratory, Howard University

Abstract Preview: Purpose: To compare the efficacy of 225Ac to 90Y for local cancer therapy by quantifying DNA damage using Monte Carlo simulations.
Methods: The TOPAS n-Bio toolkit was used to simulate the irradiat...

Evaluating the Radiological Safety of 64Cu-Macrin in PET/MRI Studies through Radiopharmaceutical Dosimetry

Authors: Alejandro Bertolet, Mislav Bobić, Carlos Huesa-Berral, Aileen O'Shea, Ralph Weissleder

Affiliation: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: To develop a pipeline for estimating the absorbed dose to various organs from positron emission tomography (PET) combined with magnetic resonance imaging (MRI). We use this pipeline to evalua...

Evaluation of Phosphorus-32 Source Uniformity Using Python Algorithm and Monte Carlo Simulation

Authors: Ana Laura Burin, Ilca Marli Moitinho Amaral Medeiros, Priscila Santos Rodrigues, Maria Elisa Chuery Martins Rostelato, Sabrina Spigaroli Sgrignoli, Ana Catarina Koka de Souza Silva, Carla Daruich Souza, Cristhian Ferreira Talacimon, Lara El Hajj Teodoro, Carlos Alberto Zeituni

Affiliation: IPEN - USP, IPEN - Instituto de Pesquisas Energéticas e Nucleares

Abstract Preview: Purpose: The uniform distribution of phosphorus-32 (32P) in beta sources is essential to ensure the accuracy of radiotherapy treatments, such as those for paravertebral cancer. This study evaluated th...

Extremity Imaging with Cone-Beam CT (CBCT) Scanner Dedicated for Hip Imaging – What Are the Effective Doses?

Authors: Jeff Boob, Jaydev K. Dave, Tim Minch, Bhavyata Tanna

Affiliation: Dr. Ronald E. McNair Academic High School, Mayo Clinic, CurveBeam AI

Abstract Preview: Purpose: To compute effective doses associated with imaging of the extremities with a HiRise (CurveBeam AI, Hatfield, PA) cone-beam CBCT scanner specifically designed for weight-bearing imaging of the...

Fetal Radiation Exposure Monitoring of Pregnant Employees across Multiple Departments and Areas in a Hospital

Authors: Janet Ching-Mei Feng, Janet Gutierrez, Aylin Ozus, Patricia Svolos

Affiliation: Bellaire High, McGovern Medical School, University of Texas Health Science Center at Houston, Environmental Health & Safety, University of Texas Health Science Center at Houston, UTHealth McGovern Medical School

Abstract Preview: Purpose: Exposure to radiation may become harmful to the fetus depending on the gestational age and absorbed dose. The Nuclear Regulatory Commission states the radiation exposure to the embryo/fetus o...

Icrp Mesh-Type Reference Computational Phantoms Representing Pregnant Women and Fetuses

Authors: Wesley E. Bolch, Chansoo Choi, Chan Hyeong Kim, Suhyeon Kim, Bangho Shin, Yeon Soo Yeom

Affiliation: Hanyang University, University of Florida, 2) Department of Radiation Convergence Engineering, Yonsei University

Abstract Preview: Purpose: Task Group 103 of International Commission on Radiological Protection (ICRP) recently released new-generation adult and pediatric mesh-type reference computational phantoms (MRCPs) via ICRP P...

Improvements from Monte Carlo Simulations over Pencil Beam Algorithms for Normal Tissue Dose Reconstruction in Proton Therapy Patients

Authors: Amy Berrington de Gonzalez, Keith T Griffin, Jae Won Jung, Cari M Kitahara, Choonik Lee, Choonsik Lee, Aimee L McNamara, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock

Affiliation: University of Michigan, East Carolina University, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School, Institute of Cancer Research

Abstract Preview: Purpose: Radiotherapy dose reconstruction enables retrospective epidemiological studies that connect late health effects to the organ-absorbed radiation doses received during treatment. Though clinica...

Investigation of Treatment Planning System (TPS) Algorithms for Helical Tomotherapy Total Body Irradiation (TBI)

Authors: John T Barrett, Chulhaeng Huh, Farshad Mostafaei, Michelle Rocque, Austin Sanders

Affiliation: Department of Radiation Oncology, Medical College of Georgia, Augusta University, Department of Radiation Oncology, Augusta University, Georgia Radiation Therapy Center, Wellstar-MCG Health

Abstract Preview: Purpose: This study involved the use of Accuray’s TPS (Precision) and RayStation TPS for planning TBI treatments. TBI was delivered using Accuray’s Radixact machine, and dose calculation algorithm, do...

Investigation on Quantifying Chemical Species Post Electron and Proton Irradiation Using the Geant4-DNA 'UHDR' Example

Authors: Konstantinos Chatzipapas, George C. Kagadis, Panagiotis Konstas, Dimitris N. Mihailidis, Dimitris Visvikis

Affiliation: LaTIM, INSERM UMR1101, University of Pennsylvania, LaTIM, INSERM, University of Brest, University of Patras

Abstract Preview: Purpose: This study investigates the temporal evolution of radiolytic species (H3O+, OH‱, OH-) in water under electron and proton irradiation using the mesoscopic chemistry model that allows longer te...

Lu-PSMA-Dose, a French Retrospective Multicentric Dosimetry Study of 177Lu-PSMA Treatments for Metastatic Castration-Resistant Prostate Cancer

Authors: NadÚge Anizan, Jean-Noël Badel, Thomas Baudier, David Broggio, Désirée Deandreis, Ludovic Ferrer, Didier Franck, Camilo Garcia, Jean Gasteuil, Anne-Laure Giraudet, Olivier Humbert, Laetitia Imbert, Malick Koulibaly, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard, Caroline Rousseau, Guido Rovera, David Sarrut, Paul Schwartz, Nicolas Varmenot

Affiliation: Institut de CancĂ©rologie de l’Ouest, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de Physique MĂ©dicale, Institut BergoniĂ©, Service de Physique MĂ©dicale, CHRU de Nancy Brabois, Service de MĂ©decine NuclĂ©aire, Centre de lutte contre le cancer LĂ©on BĂ©rard, UniversitĂ© de Lyon, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, UniversitĂ© Nice CĂŽte d’Azur, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de MĂ©decine NuclĂ©aire, Institut de CancĂ©rologie de l’Ouest, Service de Physique MĂ©dicale, Service de MĂ©decine NuclĂ©aire, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon; Centre de lutte contre le cancer LĂ©on BĂ©rard, Institut BergoniĂ©, Service de MĂ©decine NuclĂ©aire

Abstract Preview: Purpose: The main objective of the Lu-PSMA-Dose study, sponsored by ASNR, is to estimate retrospectively the individual absorbed dose delivered to patients treated with 177Lu-PSMA for metastatic castr...

Measurement of 90 Y Bremsstrahlung Dose with Thermoluminescent Dosimeters

Authors: David P. Adam, Bryan Bednarz, Tyler J Bradshaw, Wesley S. Culberson, Clifford G. Hammer, Sean Jollota, Ohyun Kwon, Jordan Teague

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiology, University of Wisconsin - Madison

Abstract Preview: Purpose: To quantify absorbed dose to water from 90YCl using thermoluminescent dosimeters (TLDs) and to acquire partial volume corrections for 90YCl positron emission tomography (PET).
Methods: Six...

Mesh-Based Multiregion Model of Adult Human Kidneys for Dosimetric Evaluation of Radiopharmaceutical Therapy

Authors: John P. Aris, Wesley E. Bolch, Chansoo Choi, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Abdul-Vehab Dozic, Amy M. Geyer, Harald Paganetti, Shreya P. Pathak, Julia D. Withrow

Affiliation: St. Luke's Health System, Massachusetts General Hospital, University of Florida

Abstract Preview: Purpose: The goal of this study was to enhance the accuracy of renal dosimetry in radiopharmaceutical therapy (RPT) by developing a more detailed and precise kidney model. In RPT, accurate dose estima...

Monte Carlo Derived Correction Factors for Ion Chambers Used in the Calibration of Gamma Knife Perfexion Model: Impact of Phantom Materials and Chamber Orientation on Dosimetric Accuracy

Authors: Catherine Coolens, Robert K. Heaton, Lalageh Mirzakhanian, Tasnim Rahman, Jan P. Seuntjens

Affiliation: Princess Margaret Cancer Centre & University of Toronto, McGill University, Princess Margaret Cancer Centre, Princess Margaret Hospital, University of Toronto

Abstract Preview: Purpose: Commissioning of a Gamma KnifeÂź (GK) (Elekta, Sweden) unit requires precise dosimetric reference measurements, particularly for small fields. The IAEA TRS-483/AAPM TG-155 code of practice (20...

Monte Carlo Simulation and Dosimetric Verification of 3D Range Modulators for a Multi-Field-Optimization Flash-IMPT Plan

Authors: Michael M Folkerts, Miriam Krieger, Pierre Lansonneur, Gerard Paquet, Petar Penchev, Christoph Schuy, Yuri Simeonov, Uli Weber, Klemens Zink

Affiliation: GSI Helmholtzzentrum fuer Schwerionenforschung, Institute of Medical Physics and Radiation Protection (IMPS), University of Applied Sciences, Varian Medical Systems

Abstract Preview: Purpose:
Ultra-high dose-rate proton irradiation may spare the healthy tissue (FLASH-effect). The 3D-range-modulator (3D-RM) method reduces the treatment time compared to conventional IMPT and can ...

On Estimating Effective Doses Associated with Different Imaging Protocols for Weight-Bearing Imaging of the Hip with a Dedicated Cone Beam CT (CBCT) Scanner

Authors: Jeff Boob, Jaydev K. Dave, Tim Minch, Bhavyata Tanna

Affiliation: Dr. Ronald E. McNair Academic High School, Mayo Clinic, CurveBeam AI

Abstract Preview: Purpose: To estimate effective doses associated with different imaging protocols for hip imaging with a cone beam CT (CBCT) scanner specifically designed for weight-bearing acquisitions.
Methods: A...

Optimizing Dosimetry in Rpt Clinics: Tackling Initial Hurdles and Ensuring Image Accuracy.

Authors: Siju C. George, Alonso N. Gutierrez, Vivek Mishra, Ranjini P. Tolakanahalli

Affiliation: Miami Cancer Institute, Baptist Health South Florida, Miami Cancer Institute

Abstract Preview: Purpose: This presentation focuses on optimizing dosimetry in RPT clinics by tackling initial setup challenges and ensuring the accuracy of SPECT/CT imaging for dosimetry. It will address the qualific...

Organ Dose Estimation from Successive CBCT Imaging for Patients Undergoing Radiation Therapy for Prostate Cancer

Authors: Panagiotis Iliopoulos, Marios Myronakis, Kyriaki Theodorou

Affiliation: Medical Physics Department, Medical School, University of Thessaly

Abstract Preview: Purpose: To estimate individualized absorbed dose at Organs at Risk (OARs) from kV Cone Beam CT (CBCT) imaging in the pelvic area, prior radiotherapy, and assess excess risk for secondary malignancies...

Personalized Dosimetric Workflow for 177Lu-PSMA Treatments Considering the Cross-Irradiation from Bone Metastases to Red Bone Marrow

Authors: NadÚge Anizan, David Broggio, Désirée Deandreis, Didier Franck, Camilo Garcia, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard

Affiliation: Gustave Roussy, Service de Physique Médicale, Institut Bergonié, Service de Physique Médicale, Gustave Roussy, Service de Médecine Nucléaire, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSE-SANTE/SDOS

Abstract Preview: Purpose: This work aimed at developing an innovative workflow for 177Lu-PSMA personalized dosimetry to lesions and organs at risk (OAR) simultaneously, considering the cross-irradiation from bone meta...

Preclinical Assessment of 68ga-Dotatate As a Surrogate for 177lu-Dotatate Dose Distribution in Radionuclide Therapy

Authors: Payman Hejazi, Faraz Kalantari, Milad Peer-Firozjaei, Romina Pourhashem, Ehsan Tajikmansoury

Affiliation: Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Medical Physics, Semnan University of Medical Sciences, Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine

Abstract Preview: Purpose:
Pretreatment biodistribution imaging play a crucial role in optimizing tumors and organ absorbed doses estimation in radionuclide therapy. Surrogating radionuclides for more efficient trea...

Preclinical Dosimetric Evaluation for Small Animal Study to Investigate Normal Tissue-Sparing Effects in the Electron Ultra-High Dose-Rate (FLASH) Environment

Authors: Ashok Bhandari, Andrew Joseph Fanning, Kyle J. Gallagher, Brendan Graff, Christopher Jenkins, Kyuhak Oh, Ying Yan, Su-Min Zhou

Affiliation: University of Nebraska Medical Center

Abstract Preview: Purpose: This study aimed to design a robust experimental setup to ensure accurate dose delivery using ultra-high-dose-rate for small animal experiments by conducting dosimetric evaluations prior to a...

Pulse-Based Method of Electrometer Calibration for High Instantaneous Currents Produced in Ultra-High Dose per-Pulse Electron Beams

Authors: Wesley S. Culberson, Miguel Angel Flores Mancera, Jeff Radtke

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison

Abstract Preview: Purpose: Electrometers are fundamental instruments for absorbed dose determination, and their accuracy is strongly dependent on their calibration. The standard procedure of electrometer calibration is...

Radiation Sub-Segmentectomy in 90y Radioembolization: Post-Therapy Dosimetry, Treatment Response, and Pathological Necrosis

Authors: Guilherme Rosa Ferreira, Dan Giardina, John Karageorgiou, Chris Malone, Allan Thomas

Affiliation: Washington University School of Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine

Abstract Preview: Purpose: Radiation segmentectomy has become a primary strategy in 90Y radioembolization, with localized treated volumes that can include up to two liver segments. The goal is complete pathological nec...

Reconstructing Radiopharmaceutical Distributions Using Coded Aperture Tomography with Photon Counting Detector

Authors: David P. Adam, Xun Jia, Youfang Lai, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University

Abstract Preview: Purpose: Radiopharmaceutical therapy is experiencing a resurgence in interest due to its potential of treating widespread metastatic disease in a patient-specific manner. Accurately measuring and desc...

Retrospective Evaluation of Combined Photon SBRT and Radium-223 SPECT Based Radiopharmaceutical Therapy Tumor Dosimetry in Clinical Trial Patient Cases

Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang

Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill

Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...

S Values for a Monkey Computational Model for Internally Distributed Radiation Sources

Authors: Jae Won Jung, Daniel Lee

Affiliation: Thomas S. Wootton High School, East Carolina University Brody School of Medicine

Abstract Preview: Purpose: Monkeys have played a key role in enhancing our understanding of the behavior of radioactive materials within living organisms in the field of nuclear medicine. However, detailed dosimetric d...

Temporal Drift in Ir-192 Source Strength Measurements: A Braphyqs Multi-Center Analysis

Authors: Åsa K. Carlsson Tedgren, Taran Hellebust, Antonio Herreros, Jacob Johansen, Christian Kirisits, Panagiotis Papagiannis, Mark J. Rivard, Frank-Andre Siebert, Frank Verhaegen, Javier Vijande, Jan Wiersma, Marisol de Brabandere, Ruud van Leeuwen

Affiliation: UKSH, Campus Kiel, Klinik fĂŒr Strahlentherapie (Radioonkologie), Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Radiation Physics, Department of Medicine and Health (IMH), Linköping University, Radiation Oncology Department, Hospital ClĂ­nic-Universitat de Barcelona, IDIBAPS, IFIC-UV, Radiation Oncology, Amsterdam UMC location University of Amsterdam, Department of Radiation Oncology, Radboud University Medical Center, Department of Oncology, Aarhus University Hospital, University Hospital Gasthuisberg, Dept. of Radiation Oncology, Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Reproduction, Maastricht University Medical Centre+, Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Warren Alpert Medical School of Brown University

Abstract Preview: Purpose: This study, which was carried out by the GEC-ESTRO BRAPHYQS working group, reports the increasing divergence between clinical reference air kerma rate (RAKR) measurements and vendor-provided ...

Using Multi-Peak Reconstructions for Dosimetry of Fast and Quantitative Lutetium-177 SPECT/CT

Authors: Julia Brosch-Lenz, Munir Ghesani, Francesc Massanes, Michael Morris, Babak Saboury, Eliot Siegel, Alexander Hans Vija

Affiliation: Institute of Nuclear Medicine, Siemens Medical Solutions USA Inc., Molecular Imaging

Abstract Preview: Purpose: Quantitative imaging of the radiopharmaceutical distribution is crucial for treatment evaluation and dosimetry. However, as patient numbers for Lutetium-177-(177Lu)-labelled therapies continu...

Validation of Radiopharmaceutical Therapy (RPT) Dose Calculation Platforms from Absolute Absorbed Dose Measurement of 225ac

Authors: Bryan Bednarz, Larry A. DeWerd, Sean Jollota, Ahtesham Ullah Khan, Ohyun Kwon, Jeff Radtke

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison

Abstract Preview: Purpose: The accurate quantification of absorbed dose is essential for alpha-emitting radionuclides used in radiopharmaceutical therapy (RPT). This study presents the first direct comparison of physic...

Voxel-Based Micro-Yucatan Minipig Phantoms for Use in Internal Dosimetry

Authors: John P. Aris, Wesley E. Bolch, Natalia Estefania Carrasco-Rojas, Ann M. Chan, Chansoo Choi, Aitor Gallastegui Menoyo, Rowan James Milner, Bangho Shin, Maria M. Von Chamier

Affiliation: University of Florida

Abstract Preview: Purpose: In preclinical studies, minipigs serve as valuable experimental models for predicting absorbed doses due to their anatomical and physiological similarities to humans. However, minipig computa...