Authors: Jingyuan Chen, Sheng Li, Tianming Liu, Wei Liu, Zhengliang Liu, Zhong Liu, Daniel Ma, Samir H. Patel, Guangya Wang, Yunze Yang
Affiliation: University of Miami, Mayo Clinic, School of Data Science, University of Virginia, School of Computing, University of Georgia, Department of Radiation Oncology, Mayo Clinic, Institute of Western China Economic Research, Southwestern University of Finance and Economics
Abstract Preview: Purpose:
Traditional patient outcome analyses relied heavily on conventional statistical models that primarily elucidate correlation rather than causal relationships. In this study, we aim to ident...
Authors: Huay Din, Grace Jianan Gang, Grace Hyun Kim, Michael F. McNitt-Gray, Joseph W. Stayman, Yijie Yuan
Affiliation: Johns Hopkins University, John Hopkins University, University of Pennsylvania, David Geffen School of Medicine at UCLA
Abstract Preview: Purpose:
Radiomics rely on quantitative features to discern underlying biological signatures. However, feature dependence on the imaging systems themselves hampers the creation of reproducible and ...
Authors: Carlo Greco, Joep Stroom, Sandra Vieira
Affiliation: Champalimaud Center for the Unknown
Abstract Preview: Purpose: RTP safety margins are generally based on geometrical uncertainties alone and not directly on clinical outcome. Here we use clinical dose-constraint data to generate dosimetric margins for OA...
Authors: Yan Chu, Madison Emily Grayson, Radhe Mohan, Pablo P. Yepes
Affiliation: UT Health Science Center at Houston, Rice University, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Radiation-induced lymphopenia (RIL) is a common adverse effect of radiation therapy, negatively impacting overall survival and anti-PD1 immunotherapy efficacy. Our lab previously developed a ...
Authors: Md Mainul Abrar, Harsh Arya, Yujie Chi, Yijing Liu, Joshua Rajan, Pan Zui
Affiliation: University of Texas at Arlington, The University of Texas at Arlington, Department of Physics, University of Texas at Arlington
Abstract Preview: Purpose: Understanding the biological effects of alpha radiation at varying dose rates and energies is essential for advancing therapeutic strategies. This study demonstrates the capabilities of an in...
Authors: Evan Calabrese, Hangjie Ji, Kyle J. Lafata, Casey Y. Lee, Eugene Vaios, Chunhao Wang, Lana Wang, Zhenyu Yang, Jingtong Zhao
Affiliation: Duke University, Department of Radiation Oncology, Duke University, Duke Kunshan University, North Carolina State University
Abstract Preview: Purpose: To develop a biologically guided deep learning (DL) model for predicting brain metastasis(BM) local control outcomes following stereotactic radiosurgery (SRS). By integrating pre-SRS MR image...
Authors: Jonathan J. Chen, Alexei V. Chvetsov, Yulun He, Ramesh Rengan, Andrew Stacey, Kent Wallner
Affiliation: University of Washington and Fred Hutchinson Cancer Center, University of Washington
Abstract Preview: Purpose: To show that the RBE of low-energy photon sources used in COMS (Collaborative Ocular Melanoma Study) eye plaques compensates for protracted irradiation and attenuation of low-energy photons i...
Authors: Christoph Bert, Leon BrĂźckner, Luitpold Distel, Julian Freier, Peter Hommelhoff, Bastian LĂśhrl
Affiliation: Department of Radiation Oncology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nßrnberg, Department Physik, Friedrich-Alexander Universität Erlangen-Nßrnberg
Abstract Preview: Purpose: Low energy electron (LEE) bunches in the kilo electronvolt (keV) range are thought to have a high relative biological effectiveness (RBE). To investigate this, it is necessary to establish re...
Authors: Alexei V. Chvetsov, Pavitra Ramesh, Alexei V. Trofimov
Affiliation: Massachusetts General Hospital, University of Washington
Abstract Preview: Purpose: To investigate the effect of dose and depth dependence of relative biological effectiveness (RBE) on hypofractionated proton therapy for ocular melanoma using equivalent uniform RBE-weighted ...
Authors: Sean P. Boyer, Shae Gans, Mingcheng Gao, Draik B. Hecksel, Mark Pankuch
Affiliation: Northwestern Medicine Proton Center, Northwestern Medicine Chicago Proton Center
Abstract Preview: Purpose: Protons deposit a large portion of their energy at the end of their range in a region known as the Bragg peak, which may increase the relative biological effective (RBE) dose in this region. ...
Authors: John Ford, Yu Fujiwara, Isao Murata, Zavier Ndum Ndum
Affiliation: Osaka University, Texas A&M University
Abstract Preview: Purpose: This study investigates how particle energy affects radiation quality and biological effectiveness with the inclusion of medical implants. Our research group used microdosimetric analysis to ...
Authors: David Alcorta, Lindsay Bolino, Olivia Canter, Seifallah Emam, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, David Loiselle, Mark Oldham, Victoria J. P. Radosova
Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke Univerity, Department of Radiation Oncology, Duke University Medical Center
Abstract Preview: Purpose: To simulate how Cherenkov light (CL) produced during radiation therapy can activate targeted photodynamic molecules. To experimentally determine dose and concentration thresholds for biologic...
Authors: Daisuke Kawahara, Yoichi Watanabe
Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, University of Minnesota Medical School
Abstract Preview: Purpose: To theoretically demonstrate that FLASH dose delivery leads to higher normal tissue sparing than conventional dose rates.
Methods: A two-component kinetic model was built for target and da...
Authors: Alejandro Bertolet, Jose Antonio Lopez-Valverde, Victor V. Onecha, Daniel Puerta
Affiliation: Dana Farber Cancer Institute/Brigham and Women's Hospital, Departamento de FĂsica AtĂłmica, Molecular y Nuclear, Universidad de Granada, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Besides its superior dose conformity, proton therapy induces greater damage to tissue than conventional radiotherapies. This increased damage is usually quantified through the concept of rela...
Authors: Niels Bassler, Jonathan Bortfeldt, Francesco Evangelista, Giulio Lovatti, Jasper Nijkamp, Rasmus Nilsson, Munetaka Nitta, Katia Parodi, Marco Pinto, Per R. Poulsen, Brita Singers Sørensen, Peter Thirolf, Erik Traneus, Taiga Yamaya
Affiliation: RaySearch Laboratories AB, National Institutes for Quantum Science and Technology, Department of Medical Physics, Ludwig-Maximilians-Universität Mßnchen (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital
Abstract Preview: Purpose: Within the SIRMIO project (Small Animal Proton Irradiator for Research in Molecular Image-Guided Radiation Oncology), we aimed to perform the first in vivo proton beam treatment with a dedica...
Authors: Barry Andricks, Stratton Black, Scott R. Floyd, Ashutosh Kotwal, Eric L. Martin, Stepan Mikhailov, Mark Oldham, Niccolo Terrando, Andrew Thompson, Ying Wu
Affiliation: Department of Physics, Duke University, Medical Physics Graduate Program, Duke University, Duke University, Department of Radiation Oncology, Duke University Medical Center, Triangle Universities Nuclear Laboratory
Abstract Preview: Purpose: To evaluate and quantify the effects of high energy electron radiation delivered at FLASH and conventional dose rates on the reproductive capability of adult C. elegans nematodes.
Methods:...
Authors: Xu Cao, Wesley S. Culberson, Aleksandra Ilina, Kendall Jarvis, Brian W Pogue, Matthew Reed, William Scott Thomas, Nathaniel Van Asselt, Albert van der Kogel
Affiliation: University of Wisconsin: Madison, University of Wisconsin: Madison School of Veterinary Medicine, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of WisconsinâMadison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose: While FLASH radiotherapy is known to reduce skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR). Currently it is not clear whether this ...
Authors: Claire Keun Sun Park, Atchar Sudhyadhom, Veena Venkatachalam, Noah Warner
Affiliation: HarvardâMIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Brigham and Womenâs Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Brigham and Womenâs Hospital and Dana Farber Cancer Institute, Harvard Medical School
Abstract Preview: Purpose: Modern radiotherapy achieves sub-millimeter spatial accuracy but fails to account for patient- and spatially-specific variations in biological response. Free radical generation (FRG), particu...
Authors: Xu Cao, Wesley S. Culberson, Aubrey Parks, Brian W Pogue, Matthew Reed, William Scott Thomas
Affiliation: University of Wisconsin: Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose: Under Ultra-High Dose Rate (UHDR) irradiation, radical-radical interactions are likely enhanced due higher density production in time and space and this alters the cascade of reactions that s...
Authors: Xiangli Cui, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences
Abstract Preview: Purpose:
Respiratory motion introduces substantial dose uncertainties in lung cancer radiotherapy, particularly affecting dose distribution in Simultaneous Integrated Boost-Stereotactic Body Radiot...
Authors: Xiangli Cui, Wei Han, Jie Li, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences
Abstract Preview: Purpose: To investigate the influence of tissue heterogeneity on proton beam linear energy transfer (LET) and relative biological effectiveness (RBE) using nine RBE models. This study quantifies the i...
Authors: Ignacio Espinoza, Ignacio Narea, Beatriz Sanchez-Nieto
Affiliation: Institute of Physics, Pontificia Universidad CatĂłlica de Chile
Abstract Preview: Purpose: This study aims to evaluate the tumor response to combined radiochemotherapy on MCF7 spheroids using an open-source multiscale computational framework. The model provides a platform to simula...
Authors: Amy Berrington de Gonzalez, Keith T Griffin, Jae Won Jung, Cari M Kitahara, Choonik Lee, Choonsik Lee, Aimee L McNamara, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock
Affiliation: University of Michigan, East Carolina University, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School, Institute of Cancer Research
Abstract Preview: Purpose: Radiotherapy dose reconstruction enables retrospective epidemiological studies that connect late health effects to the organ-absorbed radiation doses received during treatment. Though clinica...
Authors: Xu Cao, Wesley S. Culberson, Aubrey Parks, Brian W Pogue, William Scott Thomas
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose:
The hydrated electron is a critical reactive species generated during the radiolysis of water when ionizing radiation interacts with biological tissues. It plays a pivotal role in mediatin...
Authors: Marwa Y. Abdel Tawwab, Amin E Amin, Abdullah M. ElSharif, Somaia Metwally Elsayed, Magdy M. Khalil
Affiliation: School of Applied Health Science, Badr University in Cairo (BUC), Cairo, Egypt, Medical Physics, Radiation Oncology Department, Faculty of Medicine, Ain Shams University, Medical Biophysics, Department of Physics, Faculty of Science, Helwan University
Abstract Preview: Purpose: Prostate cancer radiotherapy typically employs conventional fractionation schedules over approximately eight weeks. This study investigates the effect of variations in the ι/β ratio on dose c...
Authors: Nobuki Imano, Daisuke Kawahara, Akito S Koganezawa, Yuji Murakami, Ikuno Nishibuchi, Takuya Wada
Affiliation: Department of Information and Electronic Engineering, Faculty of Science and Engineering, Teikyo University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University
Abstract Preview: Purpose: Adaptive radiotherapy (ART) compensates for treatment plans based on anatomical changes while not considering biological effects such as interruptions during treatment. This study aims to dev...
Authors: Alexei V. Chvetsov, Sunan Cui, Sunyoung Jang, Robert D. Stewart
Affiliation: University of Washington and Fred Hutchinson Cancer Center, Penn State College of Medicine, University of Washington
Abstract Preview: Purpose: To evaluate spatial variation of relative biological effectiveness (RBE) in COMS (Collaborative Ocular Melanoma Study) eye plaques with low energy 125I and 103Pd photon sources as a function ...
Authors: David Alcorta, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, Mark Oldham, Victoria J. P. Radosova
Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center
Abstract Preview: Purpose: This study attempts to simulate the activation of targeted photodynamic molecules using visible laser light and characterize the direct Reactive Oxygen Species (ROS) generated by Cherenkov an...
Authors: Xinxin Deng, Issam M. El Naqa, Jimm Grimm, Lijun Ma, Vitali Moiseenko, Timothy E. Schultheiss, Gopal Subedi, Wolfgang A. TomĂŠ, Ellen D. Yorke, Albert van der Kogel
Affiliation: Montefiore Medical Center, Wellstar Kennestone Hospital Cancer Center, H. Lee Moffitt Cancer Center, Department of Human Oncology, University of WisconsinâMadison, Department of Radiation Oncology, Wellstar Health System, Radiation Oncology, Keck School of Medicine of USC, Georgia Institute of Technology, University of California San Diego, City Of Hope National Medical Centre, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Reirradiation is increasingly utilized in clinical practice but dose-time recovery factors for human subjects remain uncertain. We constructed a reirradiation recovery model for spinal cord e...
Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey
Affiliation: Thompson Proton Center
Abstract Preview: Purpose: Linear energy transfer (LET) and variable relative biological effectiveness (RBE) evaluation are important steps in the future of proton therapy, moving beyond RBE=1.1 for all treatment plann...
Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang
Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill
Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...
Authors: Brankica Andelic, Young-Bin Cho, Tara M. Gray, Bingqi Guo, Andrew Robert Hadfield, Hakan Nordstrom, Jacob Scott, John Suh, Nara Yoon
Affiliation: Adelphi University, Elekta, Cleveland Clinic
Abstract Preview: Purpose: To investigate the biological effect of Spatially Fractionated Radiation Therapy (SFRT) within Gamma-Knife (GK) using retrospective planning for brain metastases patients. This study presents...
Authors: Muhammad Ramish Ashraf, Dixin Chen, Aaron Garza, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner, Murat Surucu
Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: FLASH radiotherapy, supported by robust preclinical evidence showing an improved therapeutic index, is advancing toward clinical trials. Clinical FLASH treatments will likely require scanning...
Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Kathryn D Held, Nicolas Henthorn, Jay LaVerne, Thongchai Masilela, Stephen J. McMahon, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin, Michael Taylor, John Warmenhoven
Affiliation: Massachusetts General Hospital, Queen's University Belfast, Massachusetts General Hospital and Harvard Medical School, University of California San Francisco, University of Manchester, Notre Dame University
Abstract Preview: Purpose: TOPAS-nBio brings a cutting-edge Monte Carlo (MC) simulation framework to the research community to test hypotheses of radiation effects at the nanometer/cell scale. Here, we present the deve...
Authors: John T Barrett, Dan Heo, Chulhaeng Huh, Farshad Mostafaei
Affiliation: Department of Radiation Oncology, Medical College of Georgia, Augusta University, Department of Radiation Oncology, Augusta University
Abstract Preview: Purpose: This study aimed to compare the tumor control probability (TCP) of radiation therapy (RT) and magnetic hyperthermia combined with RT (MHRT) in the human prostate cancer cells based on radiobi...