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Results for "cell size": 62 found

A Multi-Regional and Multi-Omics Approach to Predict Penumonitis in Patients with Locally Advanced Non-Small Cell Lung Cancer in Nrg Oncology Trial RTOG 0617

Authors: Katelyn M. Atkins, Indrin J. Chetty, Elizabeth M. McKenzie, Taman Upadhaya, Samuel C. Zhang

Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center

Abstract Preview: Purpose:
We explored a multi-regional and multi-omics approach to extract CT-based radiomics and 3D dosiomics features to predict radiation pneumonitis (RP) in patients with locally advanced Non-Sm...

A Practical Experimental Software Validation Method for Voxel-Based Personalised Dosimetry in Radiopharmaceutical Therapy

Authors: Thomas Gee, Sofia Michopoulou, Amit Nautiyal

Affiliation: University Hospital Southampton

Abstract Preview: Purpose: Dosimetry software that is accessible to departments offers new opportunities to improve patient-specific dosimetry. Prior to clinical decision-making, it is essential to validate dosimetry s...

A Retrospective Assessment of Proton Radiation Response in Brain Tumor Patients Using Diffusion-Weighted MR Imaging

Authors: Liu Hong, Wen C. Hsi, Faraz Kalantari, Romy Megahed, Ganesh Narayanasamy, Maida Ranjbar, Pouya Sabouri, Zhong Su

Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)

Abstract Preview: Purpose: Quantitative apparent diffusion coefficients (ADC) in diffusion-weighted MRI (dMRI) reflect water diffusivity and thus provide tissue cellular density information. Functional diffusion mappin...

Analysis of High School and Middle Science Teachers Learning about Medical Physics through Year-Long Educational Program

Authors: Ashley Cetnar, Lin Ding, Jeffrey E. Woollard

Affiliation: The Ohio State University, The Ohio State University - James Cancer Hospital

Abstract Preview: Purpose: A cohort of middle school and high school science teachers were selected to learn about physics in medicine, develop lesson plans for their students, participate in a Physics in Medicine fiel...

Assessing Dose Enhancement and Shadowing Effects in Head and Neck Cases with Titanium Mandibular Implants

Authors: Sarah A. Ashmeg, Travis James McCaw, Joseph Shields, Matthew Spector, Christopher Tyerech, Christopher T Wilke

Affiliation: UPMC Hillman Cancer Center, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, UPMC Hillman Cancer Center, Department of Radiation Oncology, University of Pennsylvania, UPMC

Abstract Preview: Purpose: Patients with oral cavity cancer often undergo surgical extirpation prior to radiation, and surgical implants are utilized to reconstruct the resulting defect. This study dosimetrically evalu...

BEST IN PHYSICS MULTI-DISCIPLINARY: Quantitative MRI Oximetry: Combining EPR and OE-MRI for Volumetric Mapping of Hypoxia in Tumors

Authors: Victor B. Kassey, Maciej M. Kmiec, Periannan Kuppusamy, Sergey V. Petryakov, Conner Ubert

Affiliation: Dartmouth College

Abstract Preview: Purpose: Tumor hypoxia—a state of reduced oxygen supply—is well known to affect treatment response, particularly in radiotherapy and chemotherapy. Oxygen-enhanced magnetic resonance imaging (OE-MRI) u...

Benchmarking Patient Doses for Barium Fluoroscopy Procedures: A Single-Institution Study

Authors: Wilfred R Furtado, Gary Y. Ge, Jie Zhang

Affiliation: Department of Radiology, University of Kentucky, University of Kentucky

Abstract Preview: Purpose: The United Kingdom and several other countries already have well-established diagnostic reference levels (DRLs) for gastrointestinal fluoroscopic procedures, whereas the United States does no...

Commissioning and Validation of Monaco Proton Treatment Planning System on a Compact Proton Therapy System

Authors: Shupeng Chen, Xiaoda Cong, Raymond Dalfsen, Rohan Deraniyagala, Xuanfeng Ding, James E. Dolan, Xiaoqiang Li, Jian Liang, Peilin Liu, An Qin, Martin Soukup, Craig Stevens, Xiangkun Xu, Weili Zheng

Affiliation: Corewell Health William Beaumont University Hospital, Corewellhealth William Beaumont University Hospital, William Beaumont University Hospital, Elekta, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Corewellhealth William Beaumont Hospital, Department of Radiation Oncology, Corewell Health William Beaumont University Hospital

Abstract Preview: Purpose: To facilitate clinical use of the proton feature of Monaco treatment planning system(TPS), we commissioned and validated it on a compact proton therapy system.
Methods: Pencil Beam Scannin...

Commissioning of a 3D-CRT Planning Software for a Machine with Only Flattening-Filter Free Energy

Authors: Michalis Aristophanous, Steven Blum, Laura I. Cervino, Antonio L. Damato, Karen Episcopia, Chi Huang, Shih-Chi Lin, Michelle K. Savacool

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Varian Ethos (Varian Medical Systems, Palo Alto, CA) is a 6 MV flattening-filter-free (FFF) only machine, posing a challenge in creating homogeneous dose distributions when using manual 3D-CR...

Comparison of the Sun Nuclear Multi-Met Winston Lutz Test and Varian's Machine Performance Check for Isocenter Alignment for Rotational Accuracy

Authors: Junsheng Cao, Luis A. Maduro Bustos, Khushdeep Singh

Affiliation: Overlook Medical Center, Atlantic Health System at Morristown Medical Center

Abstract Preview: Purpose: To evaluate the agreement between the Sun Nuclear Multi-Met Winston Lutz test (WL) and Varian’s Machine Performance Check (MPC) in assessing isocenter alignment, couch, and collimator rotatio...

Development and Validation of an MR-Compatible Anthropomorphic Motion Phantom for Liver Motion Assessment and MR-Linac Gating System Optimization

Authors: Tsuicheng D. Chiu, Weiguo Lu, Aaron Thomlinson, You Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center

Abstract Preview: Purpose: To develop and validate an MR-compatible anthropomorphic motion phantom to assess liver motion, real-time dosimetry, and gating system performance under controlled and reproducible respirator...

Development of Cross-Platform Application for Radiation Contamination Assessment

Authors: Wesley E. Bolch, Lotem Buchbinder Shadur, Natalia Estefania Carrasco-Rojas, Chansoo Choi, Robert Joseph Dawson, Shaheen Dewji, John Francis, Emmanual Mate-Kole, Wyatt Smither, Yitian Wang

Affiliation: Georgia Tech, University of Florida, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology

Abstract Preview: Purpose: Develop a software application capable of assessing the radiation contamination of military service members and members of the general public for fast, on-site radiological triage. The softwa...

Development of Sphere Phantoms for Quantitative Evaluation of Computed Tomography Systems Resolution

Authors: Hyo-Min Cho, Changwoo Lee

Affiliation: Korea Research Institute of Standards and Science

Abstract Preview: Purpose: We develop sphere phantoms to assess spatial resolution of computed tomography (CT) systems and validate its usability using table-top X-ray experiment systems.
Methods: We manufactured sp...

Development of a Fast Quality Assurance Software Tool for Helical Online Adaptive Radiation Therapy

Authors: Guang-Pei Chen, Mi Huang, Haidy G. Nasief, Eric S. Paulson

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Recently, kV imaging has been integrated into the Accuray Radixact platform, facilitating online adaptive and scan-plan-treat workflows with helical delivery in the near future. In order to s...

Differential Hole-Size Lattice Patterns for Escalating SFRT Dose to Large, Deep-Seated, and Unresectable Masses

Authors: Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumor’s center, surrounded by smaller diameter spheres. W...

Dosimetric Assessment of Multicriteria Optimization for Accelerated Partial Breast Irradiation (APBI)

Authors: Alyssa Gadsby, William J. Godwin, Jennifer L. Harper, Daniel G. McDonald, Jean L. Peng, Alek K. Rapchak, Sean A Roles, Austin M. Skinner, Stephanie Tan

Affiliation: Medical University of South Carolina

Abstract Preview: Purpose: Multi-Criteria Optimization (MCO) theoretically allows for increased dose control during optimization. This study is the first to compare standard optimization (SO) and MCO for accelerated pa...

Dosimetric Uncertainties Associated with Photon Small Field Dosimetry

Authors: Kazi Towmim Afrin, Imad M. Ali, Jordan West

Affiliation: University of Oklahoma Health Sciences Center, University of Oklahoma

Abstract Preview: Purpose: To evaluate quantitatively the dosimetric uncertainties associated with dose calculation and measurement of small photon fields used in stereotactic photon therapy.
Methods: The output fac...

Dosimetry Commissioning of a Commercial Cabinet X-Ray Irradiator for Small Animal Irradiation

Authors: Sang Hyun Cho, Amrit Kaphle, Sunil Krishnan, Neerajan Nepal

Affiliation: The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center

Abstract Preview: Purpose: To determine the basic dosimetry parameters and characteristics of a commercial cabinet x-ray unit for small animal irradiation as well as the specific dosimetry parameters for concurrent irr...

Evaluation of Time Delays in a Surface-Guided Radiotherapy-Based Gating System Using Exactrac Dynamic and Truebeam Linear Accelerator

Authors: Hiroki Katayama, Hiroki Kawasaki, Motonori Kitaoka, Yosuke Takahashi, Takashi Tanii, Masato Tsuzuki

Affiliation: Kagawa University Hospital

Abstract Preview: Purpose:
Surface-guided radiotherapy (SGRT) with ExacTrac Dynamic (ETD) allows motion tracking and beam gating during treatment delivery. Accurate evaluation of beam-on and beam-off delays is essen...

Evaluation of an Adaptive Denoising Diffusion Probabilistic Model (DDPM) for Fast MRI in Radiotherapy Planning of Pediatric Brain Tumors

Authors: Chia-Ho Hua, Jirapat Likitlersuang, Jinsoo Uh

Affiliation: St. Jude Children's Research Hospital

Abstract Preview: Purpose: AI-based fast MRI, which reconstructs images from undersampled k-space data, has not yet been tailored for RT planning. This study aims to evaluate the fast MRI performance of our recently pr...

Evaluation of the Isopoint System for Coincidence of Radiation and Physical Isocenter Checks of Linear Accelerators

Authors: Peter Balter, Thomas Alexander Cuthbert, Weiliang Du, Song Gao, Nicholas Zacharopoulos

Affiliation: Aktina Medical Corp, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: The purpose of this study is to evaluate the accuracy and reproducibility of a commercial product for verifying the size, location, and coincidence of physical isocenter (P_iso) and radiation...

Evaluation of the Latest Plastic Scintillating Detector System with Probe Sizes of 0.5 × 0.5 mm2 and 1.0 × 1.0 mm2 for Small Field Dosimetry

Authors: Milad BaradaranGhahfarokhi, Ashley Elizabeth Bonner, James R. Burns, Annie Cooney, George X. Ding, Kenneth L. Homann, Guozhen Luo

Affiliation: Corewell Health William Beaumont University Hospital, Vanderbilt University Medical Center

Abstract Preview: Purpose: The goal of this study was to evaluate the performance of a new plastic scintillating detector (PSD) system with 0.5×0.5 mm2 and 1.0×1.0 mm2 probes (referred to as Medscint0.5 and Medscint1.0...

Fast Synthetic-CT-Free Dose Calculation in MR Guided RT

Authors: Claus Belka, Stefanie Corradini, George Dedes, Nikolaos Delopoulos, Christopher Kurz, Guillaume Landry, Ahmad Neishabouri, Domagoj Radonic, Adrian Thummerer, Niklas Wahl, Fan Xiao

Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, LMU Munich, Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)

Abstract Preview: Purpose: In MR-guided online adaptive radiotherapy, MRI lacks tissue attenuation information necessary for accurate dose calculations. Instead of using deep learning methods to generate synthetic CT i...

Feasibility Study on Creating a Digital Twin of Digital Subtraction Angiography Data Utilizing Monte Carlo and Computational Fluid Dynamic Simulations

Authors: Ciprian N. Ionita, Parisa Naghdi, Ahmad Rahmatpour

Affiliation: University at Buffalo, SUNY: University at Buffalo

Abstract Preview: Purpose: Quantitative angiography (QA) evaluates neurovascular hemodynamics, but is affected by X-ray parameters, vessel foreshortening, and imaging chain factors like detector efficiency, pixel size,...

Fine-Tuning AI-Based Generative Models for Small-Sample Glioma MRI Generation.

Authors: Xiangli Cui, Chunyan Fu, Man Hu, Wanli Huo, Jingyu Liu, Jianguang Zhang, Yingying Zhang, Shanyang Zhao

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University, Departments of Radiation Oncology, Zibo Wanjie Cancer Hospital, Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province, College of Information Engineering, China Jiliang University, Department of Oncology, Xiangya Hospital, Central South University, College of Information Engineering, China Jiliang University, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences

Abstract Preview: Purpose: To quantify the impact of fine-tuning strategies for pre-trained AI image generation models on glioma MRI image quality and observer performance, and to determine the optimal fine-tuning conf...

First in-Vivo Proton Radiography Experiments for an Image-Guided Small Animal Irradiation Platform with a TimePix3-Based Detector Setup

Authors: Niels Bassler, Jonathan Bortfeldt, Carlos Granja, Guyue Hu, Margarita Kozak, Julie Lascaud, Kirsten Lauber, Grigory Liubchenko, Jasper Nijkamp, Cristina Oancea, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Brita Singers Sørensen, Matthias Würl

Affiliation: Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital, Advacam

Abstract Preview: Purpose: To apply in-vivo proton radiography (pRad) to aid image registration and treatment plan refinement for a novel precision image-guided small animal proton irradiation platform.

Methods:...

Geometric Alignment of MV-CBCT and Dual-Layer Kv-CBCT Projections Using Deep Learning

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Applications of combined kV-MV CBCT include metal artifact correction and material identification. Difficulties arise, however, when the imagers have misaligned geometric perspectives of the ...

Global Medical Physics Graduate Clinical Training and Development Program

Authors: Eric Addison, Stephen M. Avery, Alhassan Mohammed Baidoo, Lyna Dinh, Megan Doherty, Andrew Friberg, Sonya Gwak, Francis Hasford, Stephen Inkoom, Shannon E. O'Reilly, Ayoola Okuribido, Edem Sosu, Samuel Nii Adu Tagoe

Affiliation: University of Wisconsin, Komfo Anokye Teaching Hospital, Ghana Atomic Energy Commission, Korle Bu Teaching Hospital, University of Pennsylvania, University of Ghana, Sweden Ghana Medical Centre

Abstract Preview: Purpose: This first-of-its-kind Global Medical Physics Training and Development Program (GMPTDP) seeks to serve as an opportunity for graduate students to enhance their clinical training with a global...

HDR End-to-End Testing of Horizontal Leipzig Skin Applicators with Ir-192 Calibrated Oslds

Authors: ChangSeon Kim, Andrew Lukban, Mario Serrano-Sosa, Nadia M. Vassell

Affiliation: Mount Sinai Beth Israel

Abstract Preview: Purpose: Commissioning of Flexitron HDR horizontal Leipzig applicators typically includes indirect or direct output verification, using a well chamber specific Revised Correspondence Factor (CFrev) or...

Hyperbaric Oxygen Therapy Prior to SRS Does Not Enhance Radiosensitivity in the Murine Glioblastoma Model

Authors: Beverly Allen, Jay C. Buckey, David J. Gladstone, P. Jack Hoopes, David I Hunter, Armin Tavakkoli

Affiliation: Thayer School of Engineering, Dartmouth College, Geisel School of Medicine, Dartmouth College, Geisel School of Medicine, Thayer School of Engineering

Abstract Preview: Purpose: Hyperbaric oxygen (HBO) therapy immediately prior to radiation therapy has been proposed as treatment to enhance radiosensitivity of hypoxic tumors. A murine glioblastoma model was utilized t...

Identifying Candidates for Endobronchial Valve (EBV) Treatment for Patients with Moderate to Severe Emphysema: Exploring the Use of Estimated Lung Elasticity Using a Biomechanically Based Model Derived from CT Image Data

Authors: Ryan Andosca, Peter Boyle, Grace Hyun Kim, Minji Victoria Kim, Michael Vincent Lauria, Michael F. McNitt-Gray, Gabriel Melendez-Corres, Jack Neylon, Brad Stiehl, Pang Yu Teng

Affiliation: David Geffen School of Medicine at UCLA, University of California, Los Angeles, UCLA Department of Radiology, Department of Radiation Oncology, University of California, Los Angeles, UCLA, Cedars-Sinai Medical Center

Abstract Preview: Purpose: Endobronchial Valves (EBV) are one of the few treatment options for patients with moderate to severe emphysema. Eligibility is typically assessed from CT image data analysis including Emphyse...

Image-Guided Adaptive Proton Therapy for Head and Neck Cancer Using a Novel Gantry-Less System

Authors: Philip Blumenfeld, Jon Feldman, Yair Hillman, Michael Marash, Aron Popovtzer, Alexander Pryanichnikov, Shimshon Winograd, Marc Wygoda, Vered Zivan

Affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), P-Cure Ltd./Inc., Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem

Abstract Preview: Purpose:
Image-guided adaptive proton therapy (IGAPT) allows tailored dose adjustments to account for anatomical and physiological changes during treatment. Recent efforts have developed a cost-eff...

Impact of Proton Beam Arrangements on LETd and RBE in Organs at Risk for Nasopharyngeal Cancer

Authors: Mauricio Acosta, Zachary Fellows, Alonso N. Gutierrez, Noah S. Kalman, Kristen A. McConnell, Rob Rohe, Andrew J. Wroe, Sreenija A Yarlagadda

Affiliation: Miami Cancer Institute, Baptist Health South Florida

Abstract Preview: Purpose:
Beam selection is crucial in proton therapy to ensure optimal physical and biological dose conformity to the target while maximizing sparing of normal tissue. This work investigates the im...

Impact of Tumor-to-Normal Ratio and Glass Microsphere Particle Density on Local Progression-Free Survival Following Lobar Yttrium-90 Radioembolization

Authors: Jason Chiang, Magnus Dahlbom, Veronica Hankil, Xinyi Li, Catherine (Caffi) Meyer, Kyung Hyun Sung

Affiliation: UCLA, University of California, Los Angeles

Abstract Preview: Purpose:
Yttrium-90 (90Y) radioembolization is a well-established therapy for large or multifocal liver tumors. Accurate dosimetry is critical but remains challenging, as low particle density risks...

Impact of a Dedicated Working Group on Standardization of CT-Guided Adaptive Radiation Therapy

Authors: Anthony J. Doemer, Aharon Feldman, Ian Gallagher, Yimei Huang, Brett M. Miller, Benjamin Movsas, Kundan S Thind

Affiliation: Henry Ford Health

Abstract Preview: Purpose: CT-guided adaptive radiation therapy (CTgART) is a technical, resource intensive, procedure that involves many different radiation oncology team members. To ensure consistent, high-quality CT...

Improve the Risk Prediction of Radiation-Induced Esophagitis in Lung IMRT By an Anisotropic Dose Convolution Neural Network

Authors: Ibtisam Almajnooni, Elisabeth Weiss, Lulin Yuan

Affiliation: Virginia Commonwealth University

Abstract Preview: Purpose: We developed a deep learning neural network (DLNN) to predict the risk of radiation-induced esophagitis (RE) during lung cancer radiation therapy based on the spatial dose distribution, for t...

Initial Three-Year Machine Performance Assessment of a Superficial Radiation Therapy Unit

Authors: Vibha Chaswal, Stephen D. Davis, Alonso N. Gutierrez, Noah S. Kalman, Yongsook C. Lee, William Romaguera, Ranjini P. Tolakanahalli, D. Jay J. Wieczorek

Affiliation: Miami Cancer Institute, Baptist Health South Florida

Abstract Preview: Purpose: To report machine performance of our superficial radiation therapy unit (SRT-100 Vision, Sensus Healthcare, Boca Raton, FL) for the first three years after commissioning of the unit.
Metho...

Innovative Design and Simulation of a Pediatric-Dedicated SPECT: Enhancing Imaging Performance for a Healthier Scans in Children

Authors: Mohammadreza Ay, Nahal Daneshgar, Nima Kasraie, Abbas Monsef, Zeinab Peymani, Hadi Rezaei, Peyman Sheikhzadeh

Affiliation: University of Minnesota Medical School, Radiation Oncology, Department of Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Shiraz University of Medical Sciences, Department of Medical Physics, Tehran University of Medical Sciences, Department of Medical Physics and Biomedical Engineering, UT Southwestern Medical Center, Imam Khomeini Hospital Complex,Tehran University of Medical Sciences

Abstract Preview: Purpose:
This study aims to design and simulate an innovative pediatric-dedicated SPECT scanner optimized for children’s unique anatomical and safety needs by enhancing sensitivity in data acquisit...

Investigation of Flash Proton Irradiation Induced DNA Double Strand Breaks Under Different Free Radical Scavenger Environments

Authors: Hansong Bai, Peter Jermain, Xun Jia, Heng Li, Devin Miles, Daniel Sforza, Michael H. Shang, Daniel Robert Strauss, Keith Unger, Lingshu Yin

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, MedStar Georgetown University Hospital, Johns Hopkins University, Department of Radiation Medicine, MedStar Georgetown University Hospital

Abstract Preview: Purpose: To investigate DNA Double Strand Break (DSB) induced by FLASH proton irradiation in a repair-free plasmid DNA model under different free radical scavenging conditions in plateau and Bragg pea...

Isocenter Optimization for Linear Accelerator-Based Radiosurgical Treatment Planning for Multiple Brain Metastases

Authors: J. Daniel Bourland, Christina K Cramer, Justin M. Napolitano, James D. Ververs

Affiliation: Wake Forest University School of Medicine

Abstract Preview: Purpose:
Brain metastases (BM) can be treated with linear accelerator (LINAC)-based stereotactic radiosurgery (SRS). Treatment planning for this modality has evolved over time; treatment plans typi...

Latent Diffusion for 3D CT Reconstruction from Biplanar X-Rays

Authors: Guha Balakrishnan, Osama R. Mawlawi, Yiran Sun, Ashok Veeraraghavan

Affiliation: RICE University, UT MD Anderson Cancer Center

Abstract Preview: Purpose:
Previous deep learning (DL) techniques such as X2CT-GAN [1] has shown great promise in reconstructing realistic CT volume from biplanar X-rays, however they introduce numerous artifacts in...

Modeling Alpha-Particle Dose from Diffusing Alpha-Emitters Radiation Therapy in Tissue with Inhomogeneous Diffusion

Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang

Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...

Monte Carlo Verification of Field-Size Dependent Backscatter Effect in Superficial HDR Brachytherapy

Authors: Mandar S. Bhagwat, Casey Y. Lee

Affiliation: Duke University, Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: TG43-based dose calculation leads to inaccurate field-size dependent dose calculation in superficial HDR brachytherapy, due to full-scatter condition accounted in TG43, but not during treatme...

Next Generation Nanoparticles for Fractionated MRI-Guided Radiation Therapy

Authors: Stephanie Bennett, Ross I. Berbeco, Guillaume Bort, Needa Brown, Lena Carmes, Sandrine Dufort, Michael John Lavelle, Geraldine Le Duc, Francois Lux, Toby Morris, Zeinaf Muradova, Andrea Protti, Olivier Tillement

Affiliation: University de Lyon, NH TherAGuIX, University of Massachsetts Lowell and Dana-Farber Cancer Institute Boston, Department of Radiation & Cellular Oncology, University of Chicago, University of Central Florida, Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, NH TherAguix, Universite de Lyon, Brigham and Women's Hospital, Dana-Farber Cancer Institute

Abstract Preview: Purpose: AGuIX is a theranostic Gd-based nanoparticle currently under phase-2 clinical testing where patients receive 2-3 doses at 1-week intervals prior to imaging and irradiation. AGuIX-Bi is a new ...

On the Spectral Changes of Magna-Field Photon Beams Used in Total Body Irradiation

Authors: Larry A. DeWerd, Ahtesham Ullah Khan

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison

Abstract Preview: Purpose: Total body irradiation (TBI) technique uses high energy photon beams with extended source-to-surface distances (SSDs) to irradiate the entire patient to prepare them for bone marrow or stem c...

Optimal Lattice Design for Spatially Fractionated Radiotherapy (SFRT) of Brain Metastasis in Gamma Knife (GK)

Authors: Brankica Andelic, Young-Bin Cho, Tara M. Gray, Andrew Robert Hadfield, Hakan Nordstrom

Affiliation: Elekta, Cleveland Clinic

Abstract Preview: Purpose: Spatially Fractionated Radiotherapy (SFRT) requires highly modulated dose distribution inside a tumor volume optimized using sets of planning structure of spheres in a lattice arrangement. To...

Optimization of Impulsed Acquisition Protocols on 1.5T MRI Using Simulation-Based Bayesian Experimental Design for Cell Size Imaging

Authors: Yan Dai, Jie Deng, Xun Jia, Wen Li, Junzhong Xu

Affiliation: Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiology, Vanderbilt University Medical Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Cell size is a vital parameter in evaluating the tumor microenvironment, including cell apoptosis and radiotherapy(RT)-induced immune cell infiltration. The IMPULSED(Imaging Microstructural P...

Phantom-Based Dosimetric Comparison of Multiple CT Metal Artifact Reduction Algorithms for Head-and-Neck Radiotherapy

Authors: Loren Bell, Charles S Cathcart, Brett William Eckroate, Harold Y Hu, Joshua Kilian-Meneghin, Ke Nie, Fredrick Warburton, Zhenyu Xiong, Keying (Karen) Xu, Ning J. Yue, Yin Zhang, Lili Zhou

Affiliation: RWJBarnabas Health, Basis Scottsdale, Rutgers Cancer Institute of New Jersey

Abstract Preview: Purpose: This study compares the dosimetric impact of multiple metal artifact reduction (MAR) algorithms from different CT simulator vendors using an anthropomorphic head phantom for head-and-neck (H/...

Physics-Informed Neural Network for In Vivo Dosimetry during Proton Therapy Using Protoacoustic Tomography

Authors: Kristina Bjegovic, Yong Chen, Gilberto Gonzalez, Yankun Lang, Lei Ren, Leshan Sun, Liangzhong Xiang, Yifei Xu

Affiliation: University of Maryland School of Medicine, University of California, Irvine, University of Oklahoma Health Sciences Center, University of Oklahoma Health Science Center

Abstract Preview: Purpose: Proton therapy is becoming an increasingly popular choice for cancer treatment due to its precision, reduced side effects, and effectiveness. While dosimetry is fundamental to the success of ...

Preclinical Assessment of Novel Targeted Chelate-Based Radiopharmaceuticals for Aggressive Cancer Detection

Authors: David Alcorta, Joseph Farina, Timothy Haystead, Yiping He, Philip Hughes, David Loiselle, Marybeth Nedrud, Victoria J. P. Radosova, Jianpeng Yu

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke University School of Medicine, Duke Cancer Institute

Abstract Preview: Purpose: Targeted radiopharmaceuticals have become of widespread interest in the scientific community given their ability to detect and treat metastatic disease. We aim to validate the use of novel ch...

Quality Assurance Program for Dual Energy Subtraction Imaging-Based Markerless Tumor Tracking

Authors: Hyejoo Kang, Andrew Keeler, Mathias Lehmann, Jason Patrick Luce, Ha Nguyen, John C. Roeske

Affiliation: Varian Imaging Laboratory, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago

Abstract Preview: Purpose: Markerless tumor tracking (MTT) using dual-energy (DE) subtraction imaging is being considered as a non-invasive method to track tumors during lung cancer treatment. Prior to clinical impleme...

Radiation Dose Variability and Predictability Versus PTV Volume and Anatomical Site

Authors: Lars Ewell, Russell J. Hamilton

Affiliation: Banner University Medical Group, Bannerhealth

Abstract Preview: Purpose: To estimate the variability and predictability of radiation dose as a function of the planning target volume (PTV) size and the anatomical sites of head & neck, brain and prostate.
Methods...

Retrospective Planning Study for the Evaluation of Biological Effectiveness of Spatially Fractionated Radiation Therapy with Gamma-Knife Radiosurgery on Brain Metastases

Authors: Brankica Andelic, Young-Bin Cho, Tara M. Gray, Bingqi Guo, Andrew Robert Hadfield, Hakan Nordstrom, Jacob Scott, John Suh, Nara Yoon

Affiliation: Adelphi University, Elekta, Cleveland Clinic

Abstract Preview: Purpose: To investigate the biological effect of Spatially Fractionated Radiation Therapy (SFRT) within Gamma-Knife (GK) using retrospective planning for brain metastases patients. This study presents...

Speckle Image-Based Point Spread Function Reconstruction in Clinical Diagnostic X-Ray Systems

Authors: Jonthomas Michael Box, Isaac B. Rutel

Affiliation: University of Oklahoma Health Sciences Center

Abstract Preview: Purpose: This study assesses the feasibility of using speckle images and a modified phase retrieval algorithm to reconstruct the point spread function (PSF) of a diagnostic x-ray system. While speckle...

Streamlining Hippocampal-Sparing Whole-Brain VMAT Planning: Enhancing Efficiency and Plan Quality with an Automated Workflow

Authors: Eric C. Ford, Yulun He, Minsun Kim, Dustin Melancon, Juergen Meyer, Dong Joo Rhee, Yinghua Tao

Affiliation: Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, MD Anderson Cancer Center, University of Washington

Abstract Preview: Purpose: To develop and evaluate an automated-planning technique capable of generating high-quality treatment plans for hippocampal-sparing-whole-brain radiation therapy.
Methods: An auto-planning ...

Task-Specific Deep-Neural-Network Architecture Optimization for CBCT Scatter Correction

Authors: Hoyeon Lee

Affiliation: University of Hong Kong

Abstract Preview: Purpose: Deep-learning approaches are widely investigated for Cone-Beam CT (CBCT) scatter correction to improve the quality of the linear-accelerator mounted CBCT. This study aims to optimize the deep...

The Analysis of the Bifurcation from Immune-Limited to Immune-Escape Mode in Tumor Size

Authors: Young-Bin Cho, Jacob Scott, Nara Yoon

Affiliation: Adelphi University, Cleveland Clinic

Abstract Preview: Purpose: The immune system plays a critical role in determining cancer prognosis. Based on our prior study (Cho et al., 2023) about the bystander effect induced by immune responses in spatially design...

The Effect of Radiotherapy Structure Shape Features on the Accuracy of Their Digital Representation and Manipulation

Authors: Annie Cooney, Kenneth L. Homann, Somayeh Taghizadehghahremanloo, Adam D. Yock, Hong Zhang

Affiliation: Assistant Professor, Vanderbilt University Medical Center

Abstract Preview: Purpose:
Digital radiotherapy data has been standardized using the DICOM format. However, different radiotherapy software environments interpret identical data differently due to inherent software ...

To Establish Local Diagnostic Reference Levels (DRLs) for Head and Neck Computed Tomography (CT) Exams in Abuja, Nigeria, and to Investigate the Performance of Brain Metastasis (BM) and Brain Lesion (BL) Segmentation Techniques Using U-Net Models.

Authors: Nuraddeen Nasiru Garba, Kalpana M Kanal, Abdullahi Mohammed, Rabiu Nasiru, Muhammad SHAFIU Shehu, Daniel Vergara, Joseph Everett Wishart

Affiliation: AHMADU BELLO UNIVERSITY, ZARIA, University of Washington

Abstract Preview: Purpose: To establish local Diagnostic Reference Levels (DRLs) for head and neck computed tomography (CT) exams in Abuja, Nigeria, and to investigate the performance of brain metastasis (BM) and brain...

Using Machine Learning to Predict Esophagitis Risk in Lung Cancer Radiotherapy Based on Clinical and Dosimetric Factors

Authors: Ibtisam Almajnooni, Siyong Kim, Nathaniel Miller, Elisabeth Weiss, Lulin Yuan

Affiliation: Virginia Commonwealth University

Abstract Preview: Purpose: Radiation-induced esophagitis (RE) is a common concern in lung cancer IMRT. Recent studies have indicated that the risk of radiation side effects varies greatly with patients’ baseline clinic...

Using a Generative Adversarial Network (GAN) for Source Particle Generation in Monte Carlo Radiation Therapy Simulations

Authors: Jiankui Yuan, Dandan Zheng, Tingliang Zhuang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, University of Rochester, Varian Medical Systems, Advanced Oncology Solutions

Abstract Preview: Purpose: In Monte Carlo (MC) radiation therapy dose calculations, latent variance exists when directly applying phase-space files (PSF) with a finite number of source particles, while the latter is pr...

dosimetric Characterization of Tungsten Eye Shields Using Monte Carlo Simulation

Authors: Omer Abdulaziz Ali, Robin Hill, Nathan Huntelerslag

Affiliation: Waikato Hospital, Hamilton, New Zealand, Central Coast Cancer Centre, Gosford, Australia

Abstract Preview: Purpose: Characterizing transmission through eye shields is essential to understanding dose distribution in underlying tissues. This study aims to utilize Monte Carlo (MC) simulations to model and cha...