Authors: Alejandro Bertolet, Michael D. Farwell, Sarah Gitto, Victor V. Onecha, Daniel Pryma, Aladdin Riad
Affiliation: Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Department of Radiology, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Responses to ionizing radiation (IR) strongly correlate with the absorbed dose. At the cellular level, this is typically described by a linear-quadratic relationship provided the cell populat...
Authors: Nina Burbure, Tawfik Giaddui, Shidong Li, Curtis Miyamoto, Jeremy Price, Bin Wang
Affiliation: FCCC at Temple University Hospital, Dept. of Radiation Oncology, Fox Chase Cancer Center at Temple University Hospital
Abstract Preview: Purpose: Higher rates of local failures and toxicities challenged radiation therapy of centrally located lung cancer (CLLC). We assessed the treatment response by measuring the early changes of PET+ n...
Authors: Anthony Hong Cheol Lim, Alexander R ODell, Alexander Stanforth, Chris C. Wang
Affiliation: Georgia Institute of Technology, Emory University
Abstract Preview: Purpose: The purpose of this work is to investigate the variation of proton RBE, with respect to depth, in the context of clinical SOBP. Employing a novel approach, this study conducts a Monte Carlo s...
Authors: ISAAC Amoah, Jackie Austin, Charlotte Block, Kaylee Brilz, Dylan Bui, Andrew E. Ekpenyong, Jayce Hughes, Pralhad Itani, Natasha Ratnapradipa, Sara Strom, Jacob Woolf
Affiliation: Creighton University
Abstract Preview: Purpose:
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with a median survival of approximately 15 months despite the current standard of care, which includes s...
Authors: Nobuki Imano, Yuzuha Kadooka, Daisuke Kawahara, Misato Kishi, Yuji Murakami, Shumpei Onishi
Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Neurosurgery, Hiroshima University Hospital
Abstract Preview: Purpose: Radiomics has proven useful in predicting overall survival in glioblastoma (GBM) patients, but consistent molecular correlations remain unidentified, leaving its biological basis unclear. Thi...
Authors: Xiaolong Fu, Runping Hou, Md Tauhidul Islam, Lei Xing
Affiliation: Department of Radiation Oncology, Stanford University, Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
Abstract Preview: Purpose: To introduce a novel schematic image representation of radiomics data, called OmicsMap, for high-performance deep radiomics analysis. OmicsMap transforms tabular radiomics data into an image ...
Authors: Scott James Bright, Vered Domankevich-Bachar, Mandira Manandhar, Poliana Marinello, Yogesh Rai, Marco Freitas Reis, Alexandre Rubinstein, Gabriel O. Sawakuchi, Ronen Segal, Walison Augusto Silva Brito, Mark Wasley, Amy Wu
Affiliation: MD Anderson Cancer Center, Alpha Tau Medical Ltd, Alpha Tau Medical LTD, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Immunologically cold breast cancers are aggressive and difficult to treat due to their lack of immune cell infiltration. The combination of high-LET radiation with DNA repair inhibitors offer...
Authors: Mark E Artz, Jiyeon Park, Lori Rice, Mohammad Saki, Sanjeev Shukla, Michael Vieceli
Affiliation: University of Florida Health Proton Therapy Institute, Department of Radiation Oncology, University of Florida College of Medicine, UF Health Proton Therapy Institute, Department of Urology, University of Florida College of Medicine
Abstract Preview: Purpose: To investigate how varying levels of DNA repair mutations affect the LET sensitivity of prostate cancer cells.
Methods: The prostate cancer cell lines Du145 (low DNA repair mutations), PC3...
Authors: ISAAC Amoah, Jackie Austin, Charlotte Block, Kaylee Brilz, Dylan Bui, Andrew E. Ekpenyong, Jayce Hughes, Natasha Ratnapradipa, Sara Strom, Jacob Woolf
Affiliation: Creighton University
Abstract Preview: Purpose: Cancers of the brain and nervous system account for 1 in 100 cancer diagnoses in the US every year. Surgery, radiotherapy, and chemotherapy constitute the standard of care. For Glioblastoma (...
Authors: Jonathan J. Chen, Alexei V. Chvetsov, Yulun He, Ramesh Rengan, Andrew Stacey, Kent Wallner
Affiliation: University of Washington and Fred Hutchinson Cancer Center, University of Washington
Abstract Preview: Purpose: To show that the RBE of low-energy photon sources used in COMS (Collaborative Ocular Melanoma Study) eye plaques compensates for protracted irradiation and attenuation of low-energy photons i...
Authors: Alexei V. Chvetsov, Pavitra Ramesh, Alexei V. Trofimov
Affiliation: Massachusetts General Hospital, University of Washington
Abstract Preview: Purpose: To investigate the effect of dose and depth dependence of relative biological effectiveness (RBE) on hypofractionated proton therapy for ocular melanoma using equivalent uniform RBE-weighted ...
Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal, Chris C. Wang
Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology
Abstract Preview: Purpose: Radiobiological simulation via TOPAS-nBio requires significant computational resources and time to provide meaningful results. This study aims to decrease simulation time and computational re...
Authors: James Brugarolas, Meixu Chen, Raquibul Hannan, Payal Kapur, Jing Wang, Kai Wang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, University of Maryland Medical Center
Abstract Preview: Purpose: Accurate prognosis of clear cell renal cell carcinoma (ccRCC) is essential for guiding personalized treatment planning. In this study, we present a multi-modal ensemble model (MMEM) that inte...
Authors: Nobuki Imano, Daisuke Kawahara, Misato Kishi, Yuji Murakami
Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima University
Abstract Preview: Purpose: This study aims to develop a comprehensive Multi-score by integrating Radiomics-score (Rad-score), Gene-score derived from gene expression levels, and tumor environment Rad-score (TE-Rad-scor...
Authors: Alejandro Bertolet, Jose Antonio Lopez-Valverde, Victor V. Onecha, Daniel Puerta
Affiliation: Dana Farber Cancer Institute/Brigham and Women's Hospital, Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Besides its superior dose conformity, proton therapy induces greater damage to tissue than conventional radiotherapies. This increased damage is usually quantified through the concept of rela...
Authors: Weigang Hu, Zhenhao Li, Jiazhou Wang, Xiaojie Yin, Zhen Zhang
Affiliation: Fudan University Shanghai Cancer Center
Abstract Preview: Purpose:
This study aims to develop and validate a novel deep learning method to generate synthetic PET images for rectal cancer from MRI data. By incorporating metabolic information from the synth...
Authors: Makunda Aryal, Qiongge Li, Sook Kien Ng, Christopher F. Njeh, Edwin Quashie, Senthamizhchelvan Srinivasan, Yun Wang
Affiliation: Indiana University Medical School, Memorial Health Care System, Indiana University, Inova Hospital, Indiana University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose: Linear-Quadratic-Linear (LQL) model is a modification of the traditional Linear-Quadratic model used in radiobiology to describe cell survival in response to radiation. The LQL model extends ...
Authors: Daria Gaykalova, Ranee Mehra, Jason K Molitoris, Hajar Moradmand, Lei Ren, Amit Sawant, Phuoc Tran
Affiliation: University of Maryland School of Medicine, Maryland University Baltimore, University of Maryland, Department of Radiation Oncology, University of Maryland School of Medicine
Abstract Preview: Purpose: Radiomics extracts quantitative imaging biomarkers from medical images. However, maintaining the reproducibility and stability of selected features across institutions and parameter settings ...
Authors: Jason Chiang, Magnus Dahlbom, Veronica Hankil, Xinyi Li, Catherine (Caffi) Meyer, Kyung Hyun Sung
Affiliation: UCLA, University of California, Los Angeles
Abstract Preview: Purpose:
Yttrium-90 (90Y) radioembolization is a well-established therapy for large or multifocal liver tumors. Accurate dosimetry is critical but remains challenging, as low particle density risks...
Authors: Ignacio Espinoza, Ignacio Narea, Beatriz Sanchez-Nieto
Affiliation: Institute of Physics, Pontificia Universidad Católica de Chile
Abstract Preview: Purpose: This study aims to evaluate the tumor response to combined radiochemotherapy on MCF7 spheroids using an open-source multiscale computational framework. The model provides a platform to simula...
Authors: Clemens Grassberger, David (Bo) McClatchy, Harald Paganetti
Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Massachusetts General Hospital
Abstract Preview: Purpose: While randomized controlled trials (RCTs) are the gold standard for demonstrating efficacy, nearly 50% of late-stage clinical trials fail to meet their endpoint. Tools to study the design of ...
Authors: Beatriz Allyne Dia Carandang, Chitho P Feliciano, Teresa Sy-Ortin
Affiliation: Department of Physical Sciences and Mathematics, University of the Philippines Manila, Health Physics Research Section, Atomic Research Division, Department of Science and Technology-Philippine Nuclear Research Institute (DOST-PNRI), Graduate School, University of Santo Tomas
Abstract Preview: Purpose: To investigate the X-ray radiation-induced bystander effect (RIBE), where unirradiated cells mimic the responses of directly irradiated cells, in MCF-7 breast cancer cells in vitro to underst...
Authors: Scott James Bright, Hadil Elldakli, Mojtaba Hoseini-Ghahfarokhi, Rishab Kolachina, Poliana Marinello, Yogesh Rai, Marco Freitas Reis, Gabriel O. Sawakuchi, Walison Augusto Silva Brito, Mark Wasley
Affiliation: MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, MD Anderson Cancer Center, Medical College of Georgia
Abstract Preview: Purpose:
Glutaminase 1 (GLS1) is an intracellular enzyme crucial for generating antioxidants such as glutathione (GSH). GSH neutralizes reactive oxygen species (ROS) induced by radiotherapy. About ...
Authors: Alexei V. Chvetsov, Sunan Cui, Sunyoung Jang, Robert D. Stewart
Affiliation: University of Washington and Fred Hutchinson Cancer Center, Penn State College of Medicine, University of Washington
Abstract Preview: Purpose: To evaluate spatial variation of relative biological effectiveness (RBE) in COMS (Collaborative Ocular Melanoma Study) eye plaques with low energy 125I and 103Pd photon sources as a function ...
Authors: Lili Chen, Dusica Cvetkovic, Tristan K. Gaddis, Chang Ming Charlie Ma, Dae-Myoung Yang
Affiliation: Fox Chase Cancer Center
Abstract Preview: Purpose:
Recent studies have shown that combining photosensitizers with radiation therapy can enhance tumor control while reducing damage to normal tissues, a technique known as Radiodynamic Therap...
Authors: Todd A Aguilera, Bassel Dawod, Sebastian Diegeler, Eslam Elghonaimy, Purva Gopal, Jiaqi Liu, Hao Peng, Arely Perez Rodriguez, Nina N. Sanford, Robert Timmerman, Megan B Wachsmann, Haozhao Zhang
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center
Abstract Preview: Purpose: This study pioneers the integration of CODEX (co-detection by indexing)-based spatial profiling and advanced computational techniques to investigate the tumor immune microenvironment (TIME) i...
Authors: Ryan Gentzler, Xin He, James Larner, J.T. Morgan, Cam Nguyen, Wendy Stewart, Krishni Wijesooriya, Grant Williams
Affiliation: Department of Physics, University of Virginia, Department of Radiation Oncology, University of Virginia, Division of Hematology & Oncology, Department of Medicine, University of Virginia
Abstract Preview: Purpose: Some recent studies have shown Overall Survival (OS) of advanced-stage lung cancer patients treated with chemo-radiation therapy (CRT) is correlated with heart dose [1-5], while in other stud...
Authors: Rico Castillo, Katherine Gonzalez, Casey C. Heirman, Kyle J. Lafata, Casey Y. Lee, Xiang Li, Yvonne M Mowery, Yvonne M Mowery, Daniel Murphy, Allison Pittman, Ashlyn G. Rickard
Affiliation: Duke University, Department of Radiation Oncology, Duke University, University of Pittsburgh
Abstract Preview: Purpose: To evaluate the ability of a deep learning model to identify pathomic features in lymph nodes of preclinical head and neck squamous cell carcinoma (HNSCC) models as surrogates for predicting ...
Authors: Rachel B. Ger, Xun Jia, Youfang Lai, Todd R. McNutt, Xingyi Zhao
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University
Abstract Preview: Purpose: Radiotherapy (RT) plays an essential role for head and neck (HN) cancer treatment but often results in xerostomia due to salivary gland damage. It is important to mechanistically model the ra...
Authors: Liang Cui, Xingyu Lu, Hang Shang, LingHong Zhou
Affiliation: Southern Medical University
Abstract Preview: Purpose: This study examines how varying dose rates of radiotherapy impact normal tissues outside the target area and analyzes the protective effects and regulatory mechanisms of ultra-high dose rate ...
Authors: Stephanie Bennett, Ross I. Berbeco, Guillaume Bort, Needa Brown, Lena Carmes, Sandrine Dufort, Michael John Lavelle, Geraldine Le Duc, Francois Lux, Toby Morris, Zeinaf Muradova, Andrea Protti, Olivier Tillement
Affiliation: University de Lyon, NH TherAGuIX, University of Massachsetts Lowell and Dana-Farber Cancer Institute Boston, Department of Radiation & Cellular Oncology, University of Chicago, University of Central Florida, Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, NH TherAguix, Universite de Lyon, Brigham and Women's Hospital, Dana-Farber Cancer Institute
Abstract Preview: Purpose: AGuIX is a theranostic Gd-based nanoparticle currently under phase-2 clinical testing where patients receive 2-3 doses at 1-week intervals prior to imaging and irradiation. AGuIX-Bi is a new ...
Authors: Ramesh Boggula, Yash Somnay, Hualin Zhang
Affiliation: Radiation Oncology, Keck School of Medicine of USC, Wayne State University
Abstract Preview: Purpose: Spatially fractionated radiation therapy (SFRT) allows delivery of therapeutic doses to bulky tumors otherwise limited by dose-volume effects that threaten organ-at-risk tolerances. For negle...
Authors: Lili Chen, Andy T. Clark, Dusica Cvetkovic, Chang Ming Charlie Ma, Dae-Myoung Yang
Affiliation: Fox Chase Cancer Center
Abstract Preview: Purpose: Radiodynamic therapy (RDT) shows promise as a strategy to inhibit the metastasis of premetastatic small cell lung cancer (SCLC). This study evaluates the therapeutic effect of RDT in inhibiti...
Authors: Rico Castillo, Katherine Gonzalez, Casey C. Heirman, Kyle J. Lafata, Xiang Li, Yvonne M Mowery, Yvonne M Mowery, Allison Pittman, Ashlyn G. Rickard, Breylon Riley
Affiliation: Duke University, Department of Radiation Oncology, Duke University, University of Pittsburgh
Abstract Preview: Purpose: To evaluate the relationships between quantitative imaging biomarkers and chemoradiation resistance in head and neck squamous cell carcinoma (HNSCC) using preclinical mouse models.
Met...
Authors: Joana Antunes, Scott James Bright, David B. Flint, Mojtaba Hoseini-Ghahfarokhi, Mandira Manandhar, Poliana Marinello, Gabriel O. Sawakuchi, Tingshi Su
Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Laboratory of Instrumentation and Experimental Particle Physics; Faculty of Science of University of Lisbon, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, MD Anderson Cancer Center
Abstract Preview: Purpose: To study the accuracy of relative biological effectiveness (RBE) models to predict the RBE of a comprehensive panel of pancreatic cancer cell lines.
Methods: Clonogenic cell survival w...