Authors: ISAAC Amoah, Jackie Austin, Charlotte Block, Kaylee Brilz, Dylan Bui, Andrew E. Ekpenyong, Jayce Hughes, Pralhad Itani, Natasha Ratnapradipa, Sara Strom, Jacob Woolf
Affiliation: Creighton University
Abstract Preview: Purpose:
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with a median survival of approximately 15 months despite the current standard of care, which includes s...
Authors: Scott James Bright, Vered Domankevich-Bachar, Mandira Manandhar, Poliana Marinello, Yogesh Rai, Marco Freitas Reis, Alexandre Rubinstein, Gabriel O. Sawakuchi, Ronen Segal, Walison Augusto Silva Brito, Mark Wasley, Amy Wu
Affiliation: MD Anderson Cancer Center, Alpha Tau Medical Ltd, Alpha Tau Medical LTD, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Immunologically cold breast cancers are aggressive and difficult to treat due to their lack of immune cell infiltration. The combination of high-LET radiation with DNA repair inhibitors offer...
Authors: Mark E Artz, Jiyeon Park, Lori Rice, Mohammad Saki, Sanjeev Shukla, Michael Vieceli
Affiliation: University of Florida Health Proton Therapy Institute, Department of Radiation Oncology, University of Florida College of Medicine, UF Health Proton Therapy Institute, Department of Urology, University of Florida College of Medicine
Abstract Preview: Purpose: To investigate how varying levels of DNA repair mutations affect the LET sensitivity of prostate cancer cells.
Methods: The prostate cancer cell lines Du145 (low DNA repair mutations), PC3...
Authors: ISAAC Amoah, Jackie Austin, Charlotte Block, Kaylee Brilz, Dylan Bui, Andrew E. Ekpenyong, Jayce Hughes, Natasha Ratnapradipa, Sara Strom, Jacob Woolf
Affiliation: Creighton University
Abstract Preview: Purpose: Cancers of the brain and nervous system account for 1 in 100 cancer diagnoses in the US every year. Surgery, radiotherapy, and chemotherapy constitute the standard of care. For Glioblastoma (...
Authors: Ruirui Dong, Gernot Echner, Peter Haering, Clarence King, Carlos Murillo, Gavin Poludniowski, Nicholas Sammut, Joao Seco, Steffen Seeber, Maria Francesca Spadea, Elpida Theodoridou
Affiliation: KIT, Department of Physics and Astronomy, Heidelberg University, Karolinska Institutet, DKFZ, University of Malta
Abstract Preview: Purpose:
The goal is to develop the first benchtop X-ray FLASH system based on a conventional small animal irradiator. The small animal irradiator will be modeled using a Monte Carlo toolkit for bo...
Authors: Beatriz Allyne Dia Carandang, Chitho P Feliciano, Teresa Sy-Ortin
Affiliation: Department of Physical Sciences and Mathematics, University of the Philippines Manila, Health Physics Research Section, Atomic Research Division, Department of Science and Technology-Philippine Nuclear Research Institute (DOST-PNRI), Graduate School, University of Santo Tomas
Abstract Preview: Purpose: To investigate the X-ray radiation-induced bystander effect (RIBE), where unirradiated cells mimic the responses of directly irradiated cells, in MCF-7 breast cancer cells in vitro to underst...
Authors: Scott James Bright, Hadil Elldakli, Mojtaba Hoseini-Ghahfarokhi, Rishab Kolachina, Poliana Marinello, Yogesh Rai, Marco Freitas Reis, Gabriel O. Sawakuchi, Walison Augusto Silva Brito, Mark Wasley
Affiliation: MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, MD Anderson Cancer Center, Medical College of Georgia
Abstract Preview: Purpose:
Glutaminase 1 (GLS1) is an intracellular enzyme crucial for generating antioxidants such as glutathione (GSH). GSH neutralizes reactive oxygen species (ROS) induced by radiotherapy. About ...
Authors: Lili Chen, Dusica Cvetkovic, Tristan K. Gaddis, Chang Ming Charlie Ma, Dae-Myoung Yang
Affiliation: Fox Chase Cancer Center
Abstract Preview: Purpose:
Recent studies have shown that combining photosensitizers with radiation therapy can enhance tumor control while reducing damage to normal tissues, a technique known as Radiodynamic Therap...