Authors: Benjamin R. Awad, Bulent Aydogan, Howard J Halpern, Erik Pearson, Gage H. Redler, Jordan M. Slagowski, Rajit Tummala, Autumn E. Walter-Denzin, Jimmy Zydlo
Affiliation: University of Wisconsin-Madison Department of Human Oncology, University of Oxford, The University of Chicago, Moffitt Cancer Center, California State University, Fresno, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: Small animal models are crucial in cancer research to develop, validate, and translate basic scientific hypotheses into clinical advancements. This study aims to make small animal intensity-m...
Authors: Jonathan Dowell, Grace Francis, Wei Luo, Shane McCarthy, Janelle A. Molloy, Markus Murphy
Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Iridesce Solutions, Inc.
Abstract Preview: Purpose: A novel radiation therapy quality assurance (RT QA) device has been designed, constructed and tested. The nüFilmTM machine QA system provides a method for collecting light, mechanical and rad...
Authors: Hao Gao, Yuting Lin, Nimita Shinde, Weijie Zhang
Affiliation: Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: LATTICE, a form of spatially fractionated radiation therapy (SFRT), delivers high-dose peaks and low-dose valleys to the target volume and has been clinically used for large target volumes. H...
Authors: James Robert Castle, Joshua Misa, Damodar Pokhrel, William St. Clair
Affiliation: University of Kentucky, Department of Radiation Medicine
Abstract Preview: Purpose: We propose a novel methodology for lattice deployment in spatially fractionated radiotherapy (SFRT), using principal component analysis (PCA) to improve sphere packing within the tumor. Impro...
Authors: Brianna Baek, David J. Carlson, Zhe (Jay) Chen, Dae Yup Han, Bon Tack Koo, Hyojun Park
Affiliation: Columbia University, Canyon Crest Academy, Department of Therapeutic Radiology, Yale University School of Medicine, Department of Radiation Oncology, Chung-Ang University Gwang Myeong Hospital
Abstract Preview: Purpose: To find an optimized treatment technique and shielding design for minimizing the dose to a fetus, a Monte-Carlo simulation was performed to evaluate the dosimetric contribution.
Methods: G...
Authors: Muhammad Ramish Ashraf, Dixin Chen, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner
Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: Precise beam collimation is essential in preclinical radiotherapy studies to ensure accurate dose delivery. Manual design and fabrication of organ-specific collimators usually consist of mult...
Authors: Maria Jose Almada, Bruno Forti, Andres Lima, Carlos Daniel Venencia
Affiliation: Instituto Zunino - Fundacion Marie Curie
Abstract Preview: Purpose:
To automate the planning of radiotherapy treatments for bone metastases using a script in the ECLIPSE planning system version 15.6 with a graphical interface.
Methods:
A script was d...
Authors: Jorge Naoki Dominguez Kondo, Qihui Lyu
Affiliation: University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Targeted alpha therapy (TAT) has emerged as a highly potent therapeutic method in oncology, but its development is limited by the lack of imaging methods to quantify its dosimetry. Convent...
Authors: Sen Bai, Guyu Dai, Dong Gao, Lecheng Jia, Guangjun Li, Yanfang Liu, Ying Song, Qing Xiao, Wei Zhang
Affiliation: United Imaging Healthcare, West China Hospital of Sichuan University, Shenzhen United Imaging Research Institute of Innovative Medical Equipment
Abstract Preview: Purpose:
Electronic portal imaging device (EPID) is currently the most widely used in-vivo dosimetry (IVD) device. However, the effective detector area shortage hinders further applications. This s...
Authors: Lei Dong, Yin Gao, Taoran Li, Michael Salerno, Boon-Keng Kevin Teo, Melissa Vila
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: A novel solution, RapidArc Dynamic-RAD (Varian Medical Systems, Palo Alto, USA) has been implemented to integrate VMAT with modulation of IMRT-like static-angle ports, including use of a dyna...
Authors: David J. Carlson, Yiu-Hsin Chang, Huixiao Chen, Zhe (Jay) Chen, Blake Gaderlund, Ray Yang
Affiliation: RefleXion Medical, Department of Therapeutic Radiology, Yale University School of Medicine
Abstract Preview: Purpose: To address the root cause of dosimetric discrepancy for small central targets (<2cm) especially sensitive to geometric alignment of beamlets, by modeling higher-order oscillations of the coll...
Authors: Kai-Cheng Chuang, Oana I. Craciunescu, Christopher Kelsey, Joseph Kowalski, Nicole Larrier, Xinyi Li, Sheridan G. Meltsner, Anna E. Rodrigues, Yang Sheng, Qiuwen Wu
Affiliation: Duke University, Duke University Medical Center
Abstract Preview: Purpose: To clinically implement a Volumetric Modulated Arc Therapy (VMAT) procedure for Total Body Irradiation (TBI) with off-the-shelf tools.
Methods: Patient is treated on linac couch with a hyb...
Authors: Niko Ahjoniemi, Antti Kulmala, Katja Peltola
Affiliation: Clinical Research Institute HUS, Helsinki University Hospital
Abstract Preview: Purpose: To determine the backlash of a multileaf collimator (MLC) using four measurement methods: motor encoder (primary readout), linear potentiometer (secondary readout), amorphous silicon panel (p...
Authors: Peter Balter, Andres V Cibrian, Song Gao
Affiliation: The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: The purpose of this study is to demonstrate a means of detecting misaligned jaw face angles on the Varian TrueBeam based on a beam symmetry metric for electron beam profiles.
Methods: Duri...
Authors: Ting Chen, Siming Lu, Tanxia Qu, Hesheng Wang
Affiliation: NYU Langone Health
Abstract Preview: Purpose: This study, the first in a two-part series, aims to determine the isocenter position and size for the MR Linac UNITY, focusing on the central axis (CAX) alignment of its Multi-Leaf Collimator...
Authors: Zihao Liu, Qiwei Wu, Yanfei Xiong, Yidong Yang, Ning Zhao
Affiliation: Department of Engineering and Applied Physics, School of Physical Sciences, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China, University of Science and Technology of China
Abstract Preview: Purpose: To develop an inverse planning framework that optimizes beam angles and intensities for small animal radiotherapy and to validate its accuracy and effectiveness.
Methods: The inverse plann...
Authors: Joshua Misa, Damodar Pokhrel, William St. Clair
Affiliation: University of Kentucky, Department of Radiation Medicine
Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumor’s center, surrounded by smaller diameter spheres. W...
Authors: Makunda Aryal, Gregory Bartlett, David D. Campos, Ke Colin Huang, Sook Kien Ng, Christopher F. Njeh, Oluwaseyi Oderinde, Edwin Quashie, Ashok Tiwari, Yong Yue
Affiliation: Purdue University, Department of Radiation Oncology, Indiana University, Indiana University, Indiana University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose:
Linear accelerator-based single-isocenter Stereotactic Radiosurgery (SRS) is widely used for treating brain metastases due to its efficiency, reduced treatment time, and lower imaging dose...
Authors: Cambridge L Bui-Nguyen, Alexander S. Nguyen, Liqiang (Lee) Tao
Affiliation: Varian AOS @Epic Care, UC Berkeley
Abstract Preview: Purpose: Dynamic Winston-Lutz (WL) testing provides a comprehensive framework for evaluating the accuracy of isocenter alignment. This study investigates the impact of dynamic beam modulation, such as...
Authors: David Chighvinadze, Chieh-Wen Liu, Sugandima Weragoda, Ping Xia
Affiliation: Cleveland Clinic Sandusky, Cleveland Clinic
Abstract Preview: Purpose: To explore the feasibility of using coplanar beams with collimator angle optimization for brain SRS plans with Halcyon system.
Methods: This study used a dataset of 26 patients with 2-3 br...
Authors: Ben Archibald-Heeren, Grace Gwe-Ya Kim, Kelly Kisling, Xenia Ray
Affiliation: UC San Diego, Icon Cancer Centres, University of California, San Diego, University of California San Diego
Abstract Preview: Purpose: To evaluate improvements in external beam plans for gynecological cancers from a novel planning solution: RapidArc Dynamic (RAD) (Varian Medical Systems, Palo Alto, CA) which optimizes VMAT w...
Authors: Blessing Chinelo Akah, Daniel W. Neck, David J. Perrin, Sotirios Stathakis
Affiliation: Mary Bird Perkins Cancer Center
Abstract Preview: Purpose: To assess the reliability of the Aktina Isopoint software in evaluating different components of the linear accelerator for optimized quality assurance and linac performance
Methods: The Ak...
Authors: Peter Balter, Thomas Alexander Cuthbert, Weiliang Du, Song Gao, Nicholas Zacharopoulos
Affiliation: Aktina Medical Corp, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: The purpose of this study is to evaluate the accuracy and reproducibility of a commercial product for verifying the size, location, and coincidence of physical isocenter (P_iso) and radiation...
Authors: Anthony Hong Cheol Lim, Rayyan L Mahmood, Alexander Stanforth, Chris C. Wang, Mingyao Zhu
Affiliation: Georgia Institute of Technology, Emory University
Abstract Preview: Purpose: The purpose of this project is to test the feasibility of proton minibeam lattice radiotherapy within an existing clinical setting.
Methods:
The TOPAS code is used to model a scenario i...
Authors: Robert A. Corns, Mohammad Kanber
Affiliation: East Carolina University, East Carolina University Brody School of Medicine
Abstract Preview: Purpose:
Accurate determination of the radiation isocenter is crucial for precise radiotherapy treatments, directly impacting patient safety and treatment quality. This study presents a computation...
Authors: Gregory J Bootsma, Tunok Mondol
Affiliation: University Health Network, Princess Margaret Cancer Center
Abstract Preview: Purpose:
To evaluate the impact of prototype fluence field modulation (FFM) cone-beam CT (CBCT) on dose reduction and image quality using Monte Carlo simulations. This study particularly looks at t...
Authors: Blessing Chinelo Akah, Brad Barhorst, Daniel W. Neck, David J. Perrin, Chad Robertson, Sotirios Stathakis
Affiliation: Mary Bird Perkins Cancer Center
Abstract Preview: Purpose: To evaluate the performance and radiation isocenter of Elekta and Varian linear accelerator using Aktina Isopoint.
Methods: The Aktina Isopoint was used to measure the physical and radiati...
Authors: Peymon Ghazi
Affiliation: MALCOVA Inc.
Abstract Preview: Purpose: To develop a near scatter‐free breast CT imaging system that expands coverage of the posterior breast anatomy and enhances contrast resolution for solid masses and microcalcifications, while ...
Authors: Weiliang Du
Affiliation: The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Winston-Lutz (WL) tests are often used to localize the radiation isocenter of a linac. The selection of gantry and collimator angles can affect the accuracy of the resulting isocenter. The ef...
Authors: Dante PI Capaldi, Lu Jiang, Qihui Lyu, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Preclinical small animal studies help understand radiation-induced biological responses, toxicities, and mechanisms, facilitating the translation of new therapies to patient treatment. Int...
Authors: William T. Hrinivich, Junghoon Lee, Lina Mekki
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Biomedical Engineering, Johns Hopkins University, Johns Hopkins University
Abstract Preview: Purpose: Volumetric modulated arc therapy (VMAT) planning is a computationally expensive process. In this work, we propose a reinforcement learning (RL) framework to automatically optimize dose rate a...
Authors: Shixiong Huang, Daming Li
Affiliation: The Affiliated Nanhua Hospital, University of South China, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital
Abstract Preview: Purpose: To assess the feasibility of using target current pulse signals to evaluate the output dose of medical standing wave electronic linear accelerators.
Methods: The Target I signal of the acc...
Authors: Courtney R. Buckey, Quan Chen, Suzanne J. Chungbin, Edward L. Clouser, Yi Rong, Jun Tan, Jennifer Yan, Xiang Sheng Yan
Affiliation: Mayo Clinic Arizona, Mayo Clinic
Abstract Preview: Purpose:
To identify planning techniques that consistently result in robust VMAT-TBI plans that allow for larger patient setup errors.
Methods:
Conventional planning method often results in p...
Authors: Yijian Cao, Sean T Grace, Marissa Joyce Vaccarelli
Affiliation: Northwell
Abstract Preview: Purpose:
This study investigates the dosimetric efficacy of significantly limiting gantry angles in prostate radiation therapy to as a promising strategy to maintain plan quality while enhancing ma...