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Results for "correction pet": 53 found

A Novel Proton Lattice Modality Using Minibeams

Authors: Hao Gao, Yuting Lin, Nimita Shinde, Weijie Zhang

Affiliation: Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: LATTICE, a form of spatially fractionated radiation therapy (SFRT), delivers high-dose peaks and low-dose valleys to the target volume and has been clinically used for large target volumes. H...

A Perturbative Approach to Determine the Charge Collection Efficiency in High Dose-per-Pulse Beams

Authors: Julien Bancheri, Jan P. Seuntjens

Affiliation: Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre & University of Toronto

Abstract Preview: Purpose: To obtain an analytical expression for the charge collection efficiency of parallel-plate ionization chambers in high dose-per-pulse (DPP) beams that takes into account the square pulse time ...

A Self-Supervised Deep Learning Approach for Automatic Identification and Metal Artifact Reduction in Cone-Beam CT for Brachytherapy

Authors: Rani Anne', Wenchao Cao, Yingxuan Chen, Wookjin Choi, Firas Mourtada, Yevgeniy Vinogradskiy

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: In-room mobile cone-beam CT (CBCT) is emerging to enhance high-dose-rate (HDR) brachytherapy workflow using on-demand imaging. However, metal artifacts from X-ray markers inside gynecological...

AI-Assisted 3D Microscale Mesh Models of Human Lungs from Iodine-Stained Serial-Sectioned Histology Images and Their Dosimetry Applications

Authors: John P. Aris, Wesley E. Bolch, Robert Joseph Dawson, Bonnie N. C. President, Yitian Wang

Affiliation: Johns Hopkins University, University of Florida

Abstract Preview: Purpose: Generation of a mesh-based microscale lung model is essential for accurate dosimetry analysis. Lungs exchange air with the environment and may be exposed to alpha-particle-emitting radionucli...

Accuracy Analysis of "Sphere-Mask" Optical Positioning System in Radiotherapy of Breast Cancer

Authors: Xiu tong Lin, Tao Sun

Affiliation: Department of Radiation physics and technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Radiation physics and technology, Shandong Second Provincial General Hospital

Abstract Preview: Purpose: To compare the positioning accuracy and time efficiency of "Sphere-Mask" Optical Positioning System (OPS) and traditional laser light positioning method in breast cancer radiotherapy, and to ...

Assessment of the Impact of CT Respiratory Motion on PET SUV Quantification through Virtual Imaging

Authors: Ehsan Abadi, Darrin Byrd, Paul E. Kinahan, Katie Marie Olivas, Ehsan Samei

Affiliation: Duke University, Center for Virtual Imaging Trials, Duke University, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System, University of Washington

Abstract Preview: Purpose: To evaluate the impact of respiratory motion during CT acquisitions on PET image quantification using an integrated PET-CT simulation pipeline.
Methods: A validated CT simulator (DukeSim) ...

Automated Framework for Predicting Tumour Growth in Vestibular Schwannomas Using Contrast-Enhanced T1-Weighted MRI

Authors: Mehdi Amini, Minerva Becker, Simina Chiriac, Alexandre Cusin, Dimitrios Daskalou, Ghasem Hajianfar, Sophie Neveu, Marcella Pucci, Yazdan Salimi, Pascal Senn, Habib Zaidi

Affiliation: Geneva University Hospital, Division of Radiology, Diagnostic Department, Geneva University Hospitals, Service of Otorhinolaryngology-Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals

Abstract Preview: Purpose: Personalized prediction of vestibular schwannoma (VS) tumour growth is crucial for guiding patient management decisions toward observation versus intervention. This study proposes an automate...

Biomechanically Informed Diagnostic-to-Synthetic CT Transformation for Expedited Radiation Therapy Planning

Authors: Liyuan Chen, Steve Jiang, Chenyang Shen

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center

Abstract Preview: Purpose: Delays in radiation therapy (RT) initiation caused by conventional CT simulation processes can hinder timely treatment delivery and patient outcomes. This study proposes a Virtual Treatment S...

Breastplan-Helper: Publicly Shared Source Scripting Toolset to Assist in 3D Breast Planning

Authors: Ryan Clark, Anthony Magliari, Luis Felipe Oliveira E Silva, Yang Sheng, Jason R Vickress, Qingrong Jackie Wu, Giulianne Rivelli Rodrigues Zaratim

Affiliation: Verspeeten Family Cancer Center, Office of Medical Affairs, Varian, A Siemens Healthineers Company, Confiar Radioterapia, Duke University Medical Center

Abstract Preview: Purpose: Develop a toolset to replace several of the tedious steps required to manually generate 3D breast treatment plans using static gantry forward planned tangent beams.

Methods: Eclipse Sc...

CT-Free PET Imaging: Synthetic CT Generation for Efficient and Accurate PET-Based Planning

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
PET is used in radiotherapy workflows for accurate target delineation. However, a separate CT scan is typically required for attenuation correction in PET imaging and for registering PET-d...

Calibration of Dynamic Collimation System Trimmers to Proton Beam Axis Using Gantry-Angle-Specific Corrections: A Look-up Table Solution

Authors: Wesley S. Culberson, Albert Du, Ryan T. Flynn, Ryan Gardner, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Blake R. Smith, Nhan Vu, Karsten K. Wake

Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Iowa, Iowa Health Care

Abstract Preview: Purpose: In proton therapy, the substantial size of the gantry introduces sag, causing the proton isocenter to drift as a function of gantry angle. While the scanning magnets correct the beam’s isocen...

Characterization, Commissioning, and Clinical Evaluation of a Commercial Beo Optically Stimulated Luminescence (OSL) System

Authors: Brett G Erickson, Joseph P. Kowalski, Xinyi Li, Qiuwen Wu, Sua Yoo

Affiliation: Duke University, Mayo Clinic - Department of Radiation Oncology, Duke University Medical Center

Abstract Preview: Purpose: Characterization and commissioning of the BeO-based myOSLchip system was performed (per TG191) to assess its feasibility as a full replacement for the recalled Landauer aluminum oxide OSL in ...

Characterizing an Osld Dosimetry System for Use in a Multi-Clinic Environment

Authors: Amar K. Basavatia, Lee C. Goddard, Rachel Grimm, Wolfgang A. Tomé

Affiliation: Montefiore Medical Center

Abstract Preview: Purpose: To characterize the “MyOSL Chip” OSLD system for clinical use and compare the response of multiple readers to allow for utilization in a multi-clinic environment.
Methods: Dose calibration...

Characterizing and Modeling Higher-Order Motions of Collimator Subsystem on a 60RPM Gantry Linac for Improved Small Target Dosimetry

Authors: David J. Carlson, Yiu-Hsin Chang, Huixiao Chen, Zhe (Jay) Chen, Blake Gaderlund, Ray Yang

Affiliation: RefleXion Medical, Department of Therapeutic Radiology, Yale University School of Medicine

Abstract Preview: Purpose: To address the root cause of dosimetric discrepancy for small central targets (<2cm) especially sensitive to geometric alignment of beamlets, by modeling higher-order oscillations of the coll...

Clinical Application of Biology-Guided Radiotherapy (BgRT) to Patient Having a Cardiac Implantable Electronic Device (CIED)

Authors: Girish Bal, Thomas I. Banks, Bin Cai, Yesenia Gonzalez, Zohaib Iqbal, Paul M. Medin, Rameshwar Prasad, Chenyang Shen, Robert Timmerman, Yuanyuan Zhang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: Each year more than one million pacemakers and 200k cardioverter-defibrillators are implanted in patients worldwide. The presence of a CIED introduces challenges to the delivery of radiation ...

Clinical Validation of AI-Driven Segmentation Model for Pediatric Craniospinal Irradiation: Marked Reduction in Contouring Time and Enhanced Workflow Efficiency

Authors: Alexander Choi, William Ross Green, Christine Hill-Kayser, Gary D. Kao, Michael LaRiviere, Rafe A. McBeth, Steven Philbrook

Affiliation: Department of Radiation Oncology, University of Pennsylvania

Abstract Preview: Purpose: To validate the potential of clinical deployment of an in-house AI-driven auto-segmentation tool for pediatric craniospinal irradiation (CSI) in proton therapy, with goals of reducing manual ...

Comparative Study between Sparse Primary Sampling Grid Scatter Correction and Low-Count Monte Carlo-Based Scatter Reduction with 3-D Richardson-Lucy Denoising

Authors: Alan Rui Li, Qihui Lyu, Dan Ruan, Ke Sheng

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose:
The Sparse Primary Sampling (SPS) grid was shown in a previous computational study to improve image quality by correcting scatter-induced effects and artifacts in Cone-beam Computed Tomogr...

Comparison of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) and Singlet Oxygen Explicit Dosimetry (SOED) in BPD-Mediated PDT for Mice

Authors: Robert H Hadfield, Madelyn Johnson, Baozhu Lu, Hongjing Sun, Vikas Vikas, Brian C. Wilson, Weibing Yang, Timothy C. Zhu

Affiliation: University of Glasgow, University of Toronto, University of Pennsylvania

Abstract Preview: Purpose:
Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) has been developed as a real-time in vivo dosimetry technique for Photodynamic Therapy (PDT). This study investigates the feasibi...

Data-Driven Gating in Ga-68 PET/CT: Impacts on Patient Selection and Dosimetry Predictions in Radiopharmaceutical Therapy

Authors: Zhuo Chen, Tinsu Pan, Allan Thomas

Affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, WashU Medicine, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Misregistration between data-driven gated (DDG)-PET and CT can limit the benefits of motion correction and improved localization and quantitation. DDG-CT offers a solution to these issues. He...

Deformable Scintillator Array Dosimetry for In Vivo Volumetric Dose and Dose-Rate Validation of Uhdr Proton Therapy

Authors: Petr Bruza, Megan Clark, David J. Gladstone, Joseph Harms, Anthony E. Mascia, Brian W Pogue, Roman Vasyltsiv, Zhiyan Xiao, Rongxiao Zhang, Yongbin Zhang

Affiliation: Cincinnati Children's Proton Therapy Center, University of Missouri, Dartmouth College, Thayer School of Engineering, Dartmouth College, Washington University in St. Louis, University of Wisconsin - Madison

Abstract Preview: Purpose: With developing FLASH trials requiring diligent delivery monitoring, current proton therapy in-vivo dosimetry (IVD) cannot provide comprehensive verification, including dose and dose-rate vol...

Design of Next Generation Hemispherical Brain PET System Aiming for 1mm Resolution

Authors: Go Akamatsu, Yuma Iwao, Kurumi Narita, Hideaki Tashima, Taiga Yamaya, Eiji Yoshida

Affiliation: National Institutes for Quantum Science and Technology

Abstract Preview: Purpose: In brain positron emission tomography (PET), higher spatial resolution is better for visualizing detailed structures such as small nuclei and the layered structure of the cerebral cortex. The...

Development and Clinical Validation of a Tissue Maximum Ratio (TMR)-Based Monitor Units Second Check Script for Dynamic Conformal-Based Hyperarc Brain Radiosurgery Plans Via Scatter Correction Factors

Authors: Jacob Gooslin, Ellis Lee Johnson, Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: HyperArc radiosurgery permits treatment of multiple brain lesions using a single-isocenter improving treatment planning efficiency and workflow. A key stereotactic planning aspect is an indep...

Development of a Cadmium Zinc Telluride (CdZnTe) Detector-Based Neutron Imaging System

Authors: Soo Hyun Byun, Troy Farncombe, Edcer Jerecho DC Laguda

Affiliation: McMaster University

Abstract Preview: Purpose: We present the adaptation of a Cadmium Zinc Telluride (CdZnTe) detector, initially designed for SPECT-MR applications, to neutron imaging. This study explores a novel technique that utilizes ...

Diffusion Model-Based Motion Correction in Portable Computed Tomography for Brain: Human Observer Study

Authors: Rajiv Gupta, Rehab Naeem Khalid, Min Lang, Michael H Lev, Quirin Strotzer, Matthew Tivnan, Maryam Vejdani-Jahromi, Dufan Wu, Siyeop Yoon, Chen Zhennong

Affiliation: Massachusetts General Hospital

Abstract Preview: Purpose: Patient motion is a major source of artifacts in portable brain CT due to the slow scanning speed. A diffusion model was developed to reduce these motion artifacts. This work aims to assess t...

Direct in-Vivo Real-Time Singlet Oxygen Detection in Photofrin-Mediated Photodynamic Therapy (PDT) Using Multispectral Singlet Oxygen Dosimetry (MSOLD)

Authors: Theresa Busch, Robert H Hadfield, Madelyn Johnson, Baozhu Lu, Hongjing Sun, Brian C. Wilson, Weibing Yang, Timothy C. Zhu

Affiliation: University of Glasgow, University of Toronto, University of Pennsylvania

Abstract Preview: Purpose: Direct detection of singlet-state oxygen (¹O₂) is crucial for advancing type II photodynamic therapy (PDT), but its short lifetime makes in vivo measurement highly challenging. Although Photo...

Dose Rate Measurements of Scanning Carbon Ion Beams Using a Plastic Scintillator Detector

Authors: Motohiro Kawashima, Adrian Kugara, Masao Nakao, Shuichi Ozawa, Mutsumi Tashiro, Maria Varnava

Affiliation: Gunma University Heavy Ion Medical Center, Hiroshima High-Precision Radiotherapy Cancer Center

Abstract Preview: Purpose: This study aimed to evaluate the time-dependent dose rate characteristics of a scanning carbon ion beam using a fast-response plastic scintillator detector (PSD), with a focus on its potentia...

Dosimetric Impact of Monte Carlo Physics Models in Electronic Brachytherapy Simulations

Authors: David Ayala Alvarez, Facundo Ballester, Luc Beaulieu, Francisco Berumen-Murillo, Jean-Simon Cote, Ernesto Mainegra-Hing, Iymad Mansour, Gaël Ndoutoume-Paquet, Jan P. Seuntjens, Rowan M. Thomson, Christian Valdes, Javier Vijande, Peter G. Watson

Affiliation: Département de physique, de génie physique et d'optique, Université Laval, Princess Margaret Cancer Centre & University of Toronto, McGill University, Department of Physics and Medical Physics Unit, McGill University, IFIC-UV, University of Valencia, National Research Council Canada, Carleton University, 5Service de Physique Médicale et de Radioprotection, Centre Intégré de Cancérologie, CHU de Québec- Université Laval et Centre de recherche du CHU de Québec, Nuclear Medicine Department, Hospital Regional de Antofagasta, Université Laval, Carleton Laboratory for Radiotherapy Physics, Department of Physics, Carleton University

Abstract Preview: Purpose: Low-energy X-ray beams used in electronic brachytherapy (eBT) pose unique dosimetric challenges due to high depth-dose gradients, material-dependent detector responses, and the absence of sta...

Dual-Domain Neural Network Cone-Beam CT Correction for Online Adaptive Proton Therapy

Authors: Daniel H. Bushe, Arthur Lalonde, Hoyeon Lee, Harald Paganetti, Brian Winey

Affiliation: Universite de Montreal, Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, University of Hong Kong

Abstract Preview: Purpose: Improving the precision and fidelity of daily volumetric imaging is essential for enabling adaptive proton therapy (APT). While cone-beam CT (CBCT) provides daily volumetric imaging, their ut...

Evaluation of MRI Distortion across a Multi-Site Health System and the Importance of MRI Distortion QA in Stereotactic Radiosurgery (SRS)

Authors: Emel Calugaru, Jenghwa Chang, Sean T Grace, Nicholas Harvey, Jessica Jung, Ching-Ling Teng

Affiliation: Northwell, Hofstra University, Hofstra University Medical Physics Program

Abstract Preview: Purpose: To evaluate the consistency of MRI distortion corrections across Northwell Health system and evaluate the necessity and importance of distortion QA for MRIs used for stereotactic radiosurgery...

First In Vivo Proton Beam Irradiation of Mice with Quasi-Real-Time Range Verification with the Sirmio PET Scanner

Authors: Niels Bassler, Jonathan Bortfeldt, Francesco Evangelista, Giulio Lovatti, Jasper Nijkamp, Rasmus Nilsson, Munetaka Nitta, Katia Parodi, Marco Pinto, Per R. Poulsen, Brita Singers Sørensen, Peter Thirolf, Erik Traneus, Taiga Yamaya

Affiliation: RaySearch Laboratories AB, National Institutes for Quantum Science and Technology, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital

Abstract Preview: Purpose: Within the SIRMIO project (Small Animal Proton Irradiator for Research in Molecular Image-Guided Radiation Oncology), we aimed to perform the first in vivo proton beam treatment with a dedica...

First in-Vivo Application of a Novel Precision Small Animal Irradiation Platform with Proton IMPT Delivery and Advanced on-Board Image-Guidance

Authors: Niels Bassler, Jonathan Bortfeldt, Davide Boscaini, Francesco Evangelista, Guyue Hu, Ze Huang, Margarita Kozak, Julie Lascaud, Giulio Lovatti, Eero Lönnqvist, Jasper Nijkamp, Munetaka Nitta, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Babak Sharifi, Brita Singers Sørensen, Peter Thirolf

Affiliation: Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital

Abstract Preview: Purpose: To perform the first in vivo application of a novel small animal radiation research platform combining on-board image-guidance with multi-field intensity modulated spot scanning delivery [1] ...

First in-Vivo Proton Radiography Experiments for an Image-Guided Small Animal Irradiation Platform with a TimePix3-Based Detector Setup

Authors: Niels Bassler, Jonathan Bortfeldt, Carlos Granja, Guyue Hu, Margarita Kozak, Julie Lascaud, Kirsten Lauber, Grigory Liubchenko, Jasper Nijkamp, Cristina Oancea, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Brita Singers Sørensen, Matthias Würl

Affiliation: Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital, Advacam

Abstract Preview: Purpose: To apply in-vivo proton radiography (pRad) to aid image registration and treatment plan refinement for a novel precision image-guided small animal proton irradiation platform.

Methods:...

Generalized 2D Cine Multi-Modal MRI-Based Dynamic Volumetric Reconstruction Using Motion-Aligned Implicit Neural Network with Spatial Prior Embedding

Authors: Ming Chao, Karyn A Goodman, Yang Lei, Tian Liu, Jing Wang, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai

Abstract Preview: Purpose: Real-time volumetric MRI is essential for motion management in MRI-guided radiotherapy (MRIgRT), yet acquiring high-quality 3D images remains challenging due to time constraints and motion ar...

Geometric Alignment of MV-CBCT and Dual-Layer Kv-CBCT Projections Using Deep Learning

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Applications of combined kV-MV CBCT include metal artifact correction and material identification. Difficulties arise, however, when the imagers have misaligned geometric perspectives of the ...

High Resolution Head Motion Correction Based on Pilot Tone Signals – a Calibration-Free Method

Authors: Cheng-Chieh Cheng, Jeffrey P Guenette, Yajun Li, Bruno Madore, Lei Qin

Affiliation: Brigham and Women's Hospital, National Sun Yat-sen University, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Pilot tone (PT), a compact RF sensor, has been integrated into clinical practice for motion detection. Prior studies proposed mapping PT signals to head positions using a calibration step tha...

Impact of Beamline Mis-Adjustment Following Central Beamline Replacement for Halcyon Linear Accelerator

Authors: Emily Y. Hirata, Xiaoyu Sherry Liu, Evan Porter, Manju Sharma

Affiliation: University of California San Francisco, University of California, San Francisco, University of California

Abstract Preview: Purpose: Introduced in 2018, the Varian Halcyon platform has increased in popularity due to its reduced cost, user-friendly design, and operational efficiency. As this platform ages, major repairs, in...

Impact of Time-of-Flight Reconstruction and Motion Correction on PET-Based Dosimetry in 90y Radioembolization for Hepatocellular Carcinoma

Authors: Spencer Behr, Joseph Grudzinski, Youngho Seo, Jaehoon Shin, Yiran Wang, Frederick J. Wilson

Affiliation: University of California San Francisco, University of California, San Francisco, Voximetry, Inc., Voximetry, Inc

Abstract Preview: Purpose: Voxel-level imaging-based dosimetry enables a significant improvement in accurate and personalized treatment planning in radiopharmaceutical therapy, potentially leading to optimized disease ...

Implementing TG-191 for Robust Calibration of Scintillation Imaging As a Clinical dosimetry Tool

Authors: Petr Bruza, Megan Clark, David J. Gladstone, Lesley A Jarvis, Allison Matous

Affiliation: Thayer School of Engineering, Dartmouth College, Dartmouth Cancer Center, Dartmouth Health

Abstract Preview: Purpose: Scintillation imaging has demonstrated unique advantages to existing clinical in vivo dosimetry (IVD) techniques by enabling full-field visualization, direct comparison to the treatment plan,...

Improving Output Stability with Angular Correction Factor on Pencil Beam Scanning Proton System

Authors: Akbar Anvari, Carnell J. Hampton, Melanie R. Piantino, Kai Yang

Affiliation: Levine Cancer Institute, Atrium Health

Abstract Preview: Purpose: To evaluate the effectiveness of angular correction factor for output stability on Mevion S250i Hyper scanning machine, which allows user to apply correction factors for output at selected ga...

Innovative Workflow for Enhanced in-Vivo Dosimetry Using Gafchromic Film

Authors: Salim Balik, Nguyen Phuong Dang, Hualin Zhang

Affiliation: Radiation Oncology, Keck School of Medicine of USC

Abstract Preview: Purpose: An accurate and convenient monitoring of radiation dose delivery during treatment is essential for ensuring patient safety and treatment efficacy. This project aims to develop innovative algo...

Interplay of Relative Biological Effectiveness and Dose Rate in Eye Plaque Brachytherapy with Low Energy Photons

Authors: Alexei V. Chvetsov, Sunan Cui, Sunyoung Jang, Robert D. Stewart

Affiliation: University of Washington and Fred Hutchinson Cancer Center, Penn State College of Medicine, University of Washington

Abstract Preview: Purpose: To evaluate spatial variation of relative biological effectiveness (RBE) in COMS (Collaborative Ocular Melanoma Study) eye plaques with low energy 125I and 103Pd photon sources as a function ...

Investigating the Use of a DWI Phantom for Routine QA of an MR-Linac at Room Temperature

Authors: Nicholas Carlson, Joel J. St-Aubin

Affiliation: University of Iowa Hospitals and Clinics, University of Iowa

Abstract Preview: Purpose: To establish baselines metrics and determine longitudinal accuracy and reproducibility of Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values for a 1.5T Elekta Un...

Lu-177 Recovery Coefficients Using Tc-99m Surrogate Method: Intra- & Inter-Scanner Comparison

Authors: Ben Piacitelli, Celeste Winters

Affiliation: OHSU, Department of Diagnostic Radiology, Oregon Health & Science University

Abstract Preview: Purpose: To compare recovery coefficients measured with Lu-177 and Tc-99m with the goal of assessing accuracy of the Tc-99m surrogate method and comparing RC reproducibility between scanners of the sa...

Measurement of 90 Y Bremsstrahlung Dose with Thermoluminescent Dosimeters

Authors: David P. Adam, Bryan Bednarz, Tyler J Bradshaw, Wesley S. Culberson, Clifford G. Hammer, Sean Jollota, Ohyun Kwon, Jordan Teague

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiology, University of Wisconsin - Madison

Abstract Preview: Purpose: To quantify absorbed dose to water from 90YCl using thermoluminescent dosimeters (TLDs) and to acquire partial volume corrections for 90YCl positron emission tomography (PET).
Methods: Six...

Minimizing Positioning Errors in Intracranial SRS: The Role of Verification Imaging after 6-Dof Corrections

Authors: Anthony J. Doemer, Yimei Huang, Benjamin Movsas, Ellen Park, Mira Shah, Salim Siddiqui, Karen C. Snyder, Kundan S Thind, Bo Zhao

Affiliation: Henry Ford Health

Abstract Preview: Purpose: The 6 degrees-of-freedom (6-DoF) robotic couch is considered essential for linac-based stereotactic radiosurgery (SRS), particularly for irregularly shaped targets adjacent to critical organs...

Moving Towards Independent Assays of 90y Glass Microsphere Activity: Monte Carlo Simulation with Experimental Data

Authors: Mercy Iyabode Akerele, Yuni K. Dewaraja, Richard Laforest, Justin K. Mikell, Wendy Siman, Allan Thomas, Daniel Thorek

Affiliation: University of Michigan, Washington University School of Medicine in St. Louis, Washington University School of Medicine, University of Colorado Anschutz Medical Campus, School of Medicine, Washington University in St. Louis, Mallinckrodt Institute of Radiology, Washington University School of Medicine

Abstract Preview: Purpose: Post-therapy quantitative 90Y SPECT and PET measurements show ~25% lower activity than vendor-reported values for glass microspheres. We hypothesize this discrepancy is due to bremsstrahlung ...

Prediction of Metastasis-Free Survival in Patients with Prostate Adenocarcinoma Using Primary Tumor and Lymph Node Radiomics from Pre-Treatment PSMA PET/CT Scans.

Authors: Ozan Cem Guler, William Silva Mendes, Sangbo Oh, Cem Onal, Lei Ren, Apurva Singh, Phuoc Tran

Affiliation: University of Maryland School of Medicine, Baskent University Faculty of Medicine, Department of Radiation Oncology, Department of Radiation Oncology, University of Maryland School of Medicine

Abstract Preview: Purpose: To predict metastasis-free survival (MFS) for patients with prostate adenocarcinoma treated with androgen deprivation therapy and external radiotherapy using clinical factors and radiomics ex...

Radiological Assessment of Radiochromic Film Models EBT3 and EBT4 in Proton Beams

Authors: Kuan Ling Chen, Jiajin Fan, Rao Khan, Robabeh Rahimi

Affiliation: University of Maryland, Inova Schar Cancer Institute, Howard University

Abstract Preview: Purpose: This study evaluates the dose response, energy dependency, sensitivity, reproducibility, temporal response, and LET dependency along and in the plane perpendicular to a clinical proton beam f...

Radiopathomic Characterization of Chemoradiation Resistance in Preclinical Models of Head and Neck Cancer

Authors: Rico Castillo, Katherine Gonzalez, Casey C. Heirman, Kyle J. Lafata, Xiang Li, Yvonne M Mowery, Yvonne M Mowery, Allison Pittman, Ashlyn G. Rickard, Breylon Riley

Affiliation: Duke University, Department of Radiation Oncology, Duke University, University of Pittsburgh

Abstract Preview: Purpose: To evaluate the relationships between quantitative imaging biomarkers and chemoradiation resistance in head and neck squamous cell carcinoma (HNSCC) using preclinical mouse models.

Met...

Surface Mapping of Couch Kick Cherenkov Images for Rotation-Independent Treatment Verification in External Beam Radiotherapy

Authors: Petr Bruza, Alexander Geiersbach, David J. Gladstone, Lesley A Jarvis, Allison Matous

Affiliation: Thayer School of Engineering, Dartmouth College, Dartmouth Cancer Center, Dartmouth Health

Abstract Preview: Purpose: During external beam radiation therapy, couch kicks are often necessary to achieve effective treatments, yet they make interpreting Cherenkov images much more challenging. We present a surfac...

Task-Specific Deep-Neural-Network Architecture Optimization for CBCT Scatter Correction

Authors: Hoyeon Lee

Affiliation: University of Hong Kong

Abstract Preview: Purpose: Deep-learning approaches are widely investigated for Cone-Beam CT (CBCT) scatter correction to improve the quality of the linear-accelerator mounted CBCT. This study aims to optimize the deep...

The Use of a Milled NIST Traceable Tld for End-to-End Validation in Mlc and Cone SRS Programs.

Authors: Ross Bland, Zachary A. Christ, Sophy Mangana, Feba Mathew, Stephanie K. Phoenix, Joseph Salloum, Jason D. Stanford, William Zollinger

Affiliation: Forrest General Cancer Center, Northeast Louisiana Cancer Institute, Florida Atlantic University

Abstract Preview: Purpose: The objective of this paper is twofold: 1) to explore the efficacy of using referenced beam models supplied by the vendor (Brainlab) and 2) the efficacy of NIST traceable TLD for end-to-end v...

Using Multi-Peak Reconstructions for Dosimetry of Fast and Quantitative Lutetium-177 SPECT/CT

Authors: Julia Brosch-Lenz, Munir Ghesani, Francesc Massanes, Michael Morris, Babak Saboury, Eliot Siegel, Alexander Hans Vija

Affiliation: Institute of Nuclear Medicine, Siemens Medical Solutions USA Inc., Molecular Imaging

Abstract Preview: Purpose: Quantitative imaging of the radiopharmaceutical distribution is crucial for treatment evaluation and dosimetry. However, as patient numbers for Lutetium-177-(177Lu)-labelled therapies continu...