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Results for "dct unet": 99 found

A Diffusion-Based AI Framework for Continuous Deformable Image Registration and Time-Resolved Dynamic CT Generation

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Gregory Szalkowski, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: Respiratory motion management is crucial for accurate radiation delivery to moving targets while protecting healthy tissue, relying on time-resolved volumetric imaging and continuous deformab...

A Foundational Model for Medical Imaging Modality Translation in Head and Neck Radiotherapy

Authors: Jie Deng, Yunxiang Li, Xiao Liang, Weiguo Lu, Jiacheng Xie, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas

Abstract Preview: Purpose: Recently, foundational models trained on large datasets have shown remarkable performance across various tasks. Developing a foundational model for medical image modality translation in head-...

A Method to Expedite Quality Assurance for Head and Neck Ctvs with Lymph Node Level Auto-Autocontouring and Identification

Authors: Beth M. Beadle, Adrian Celaya, Laurence Edward Court, David Fuentes, Anna Lee, Tze Yee Lim, Dragan Mirkovic, Amy Moreno, Raymond Mumme, Tucker J. Netherton, Callistus M. Nguyen, Jaganathan A Parameshwaran, Jack Phan, Carlos Sjogreen, Sara L. Thrower, Congjun Wang, He C. Wang, Xin Wang

Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Radiation Oncology, Stanford University, The University of Texas MD Anderson Cancer Center, MD Anderson Cancer Center, MD Anderson, Rice University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Quality assurance of target volumes from radiotherapy clinical trials is a labor and resource intensive task. The purpose of this work is to quantify the accuracy of a tool that automatically...

A Modular Approach to Reversible and Stackable Medical Imaging Translation Models: CBCT-Based Synthetic MRI with Multiple U-Nets in Series (MUNETs)

Authors: Eric Chang, Nguyen Phuong Dang, Andrew Lim, Lauren Lukas, Lijun Ma, Yutaka Natsuaki, Zhengzheng Xu, Hualin Zhang

Affiliation: Radiation Oncology, Keck School of Medicine of USC

Abstract Preview: Purpose: Harnessed the power of AI and Deep Learning (DL), Generalized Neural Network models for medical image transformation are trained to predict target images from reference images, often requirin...

A Pilot Study to Implement a Definitive Breast SBRT Technique

Authors: Charmainne Cruje, Maria Dumol, Nawroz Fatima, Marisa Finlay, Kalaina Johnson, Raman Mohla, Jasleen Uppal

Affiliation: Trillium Health Partners, Carlo Fidani Regional Cancer Centre

Abstract Preview: Purpose: To evaluate the robustness of a breast SBRT protocol in achieving target coverage by utilizing online- and retrospectively-matched CBCT-to-CT images.
Methods: The first pilot patient was s...

A Realistic Computer Simulation Study Assessing How Beam Hardening Affects the Accuracy of CT Lung Attenuation Values

Authors: Zijia Guo, Michael F. McNitt-Gray, Frederic Noo, Karl Stierstorfer

Affiliation: Siemens Healthineers, University of Utah, David Geffen School of Medicine at UCLA

Abstract Preview: Purpose: Accurately assessing lung parenchyma health is critically important in the management of patients with chronic obstructive pulmonary disease. CT attenuation values are valuable for this purpo...

A Self-Supervised Deep Learning Approach for Automatic Identification and Metal Artifact Reduction in Cone-Beam CT for Brachytherapy

Authors: Rani Anne', Wenchao Cao, Yingxuan Chen, Wookjin Choi, Firas Mourtada, Yevgeniy Vinogradskiy

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: In-room mobile cone-beam CT (CBCT) is emerging to enhance high-dose-rate (HDR) brachytherapy workflow using on-demand imaging. However, metal artifacts from X-ray markers inside gynecological...

A Tumor Tracking Method in Surface-Guided Radiotherapy

Authors: Penghao Gao, Zejun Jiang

Affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Artificial Intelligence Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: Real-time tumor tracking can effectively compensate for the impact of respiratory motion on dose distribution. We propose a patient-specific external-internal correlation model driven by opti...

AI-Based SBRT Dose Prediction Directly from Diagnostic PET/CT: Applications for Multi-Disciplinary Lung Cancer Care

Authors: Pradeep Bhetwal, Wookjin Choi, Adam Dicker, Rupesh Ghimire, Yingcui Jia, Lauren Nkwonta, Yevgeniy Vinogradskiy, Wentao Wang, Maria Werner-Wasik

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: Multi-disciplinary clinics are becoming standard of care for patients with lung cancer treated with SBRT. To improve clinical decision support in a multi-disciplinary clinic, it would be bene...

Abdomen CT Multi-Organ Segmentation Using Multi-Granularity Feature Extraction

Authors: Zilei Fu, Yi Guo, Wanli Huo, Hongdong Liu, Laishui Lyu, Zhao Peng, Yaping Qi, Senting Wang

Affiliation: Department of Radiotherapy, cancer center, The First Affiliated Hospital of Fujian Medical University, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University, Division of lonizing Radiation Metrology, National Institute of Metrology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, China Jiliang University, Department of Oncology, Xiangya Hospital, Central South University

Abstract Preview: Purpose: Medical image boundaries are commonly characterized by smooth gray-level transitions, resulting in pixel-level segmentation errors near these blurred boundaries. To address this, we developed...

Advancing Cardiac Sparing with Upright Patient Geometry and Deep Learning

Authors: Shae Gans, Carri K. Glide-Hurst, Mark Pankuch, Chase Ruff, Niek Schreuder, Nicholas R. Summerfield, Yuhao Yan

Affiliation: Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Northwestern Medicine Proton Center, Northwestern Medicine Chicago Proton Center, Leo Cancer Care

Abstract Preview: Purpose: Novel upright patient positioners coupled with diagnostic-quality vertical CT at treatment isocenter introduce a significant opportunity for improved image-guided particle therapy. Treating p...

Analysis of Inter-Organ Noise Variability for Clinical CT Images across 3133 Image Series

Authors: Lavsen Dahal, Francesco Ria, Ehsan Samei, Justin B. Solomon, Liesbeth Vancoillie, Yakun Zhang

Affiliation: Duke University, Carilion Clinic, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System

Abstract Preview: Purpose: Clinical diagnostic task-based optimization of CT procedures require precise and organ-specific assessments. This study investigates inter-organ noise variability to highlight the limitations...

Analysis of Orthopedic Metal Artifact Reduction’s (O-MAR’s) Effectiveness on Correcting Typical Anatomical Structure Average Volumetric Hounsfield Unit (AVHU) Values Due to High-Density Metal Artifacts

Authors: John T Barrett, Mehnaz Haque, Chulhaeng Huh, Shands James, Thomas B. Lavin, Anobel Maghsoodpour, Farshad Mostafaei, Austin Sanders

Affiliation: Department of Radiation Oncology, Augusta University, Department of Radiation Oncology, Medical College of Georgia, Augusta University, Georgia Radiation Therapy Center, Wellstar-MCG Health, Department of Radiation Oncology, Doctors Hospital of Augusta, Department of Radiology and Imaging, Augusta University

Abstract Preview: Purpose: This study assesses Philips’ O-MAR effectiveness in adjusting AVHU values of common anatomical materials affected by various high-density metal artifacts at varying distances.

Methods:...

Assessing the Risks of Synthetic MRI Data in Deep Learning: A Study on U-Net Segmentation Accuracy

Authors: Chuangxin Chu, Haotian Huang, Tianhao Li, Jingyu Lu, Zhenyu Yang, Fang-Fang Yin, Tianyu Zeng, Chulong Zhang, Yujia Zheng

Affiliation: The Hong Kong Polytechnic University, Nanyang Technological University, Australian National University, Medical Physics Graduate Program, Duke Kunshan University, North China University of Technology, Duke Kunshan University

Abstract Preview: Purpose: Deep learning segmentation models, such as U-Net, rely on high-quality image-segmentation pairs for accurate predictions. However, the recent increasing use of generative networks for creatin...

Assessment of the Radiological Features of 3D-Printed Polylactic Acid Composites for Creating Personalized Dosimetric Phantoms

Authors: Ashish Binjola, Raj Kishore Bisht, Natanasabapathi Gopishankar, Pratik Kumar, Daya Nand Kishore Sharma, Sukhvir Kishore Singh, Subramani Vellaiyan

Affiliation: Medical Physics Unit, All India Institute of Medical Sciences, All India Institute of Medical Sciences, Department of Radiological Safety, Institute of Nuclear Medicine and Allied Sciences, Department of Radiation Oncology, All India Institute of Medical Sciences

Abstract Preview: Purpose: Additive manufacturing is increasingly being explored to create dosimetry phantoms. Commercial anthropomorphic phantoms represent an average patient and lack anatomical variations due to obes...

Automated Full-Body Tumor Segmentation from PET/CT Images

Authors: Austin Castelo, Xinru Chen, Caroline Chung, Laurence Edward Court, Jaganathan A Parameshwaran, Zhan Xu, Jinzhong Yang, Yao Zhao

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose:
To develop a deep learning-based segmentation model to automatically delineate tumors from full-body PET/CT images.
Methods:
PET/CT image pairs of 91 patients were collected for this...

Automated Multimodal Image Registration for Prostate Bed Radiation Treatment

Authors: Quan Chen, Xue Feng, Chunhui Han, Gaofeng Huang, Trevor Ketcherside, Yi Lao, Yun Rose Li, An Liu, Bo Liu, Kun Qing, William T. Watkins

Affiliation: Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, Department of Radiation Oncology, City of Hope National Medical Center, Mayo Clinic Arizona, Carina Medical LLC

Abstract Preview: Purpose: New treatment platforms such as Ethos (Varian Medical Systems) allow the introduction of multi-modal imaging into adaptive radiotherapy workflow to facilitate an up-to-date view of patients’ ...

Automated Tool for Radiotherapy Initial Patient Setup: A Robust Approach Based on Vertebral Identification

Authors: Hailun Pan, Yingli Yang, Jie Zhang, Yibin Zhang

Affiliation: Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Radiology, Ruijin Hospital, Department of Radiation Oncology, Ruijin Hospital, , Shanghai Jiaotong University School Of Medicine, Shanghai United imaging Healthcare Advanced Technology Research Institute

Abstract Preview: Purpose: Accurate patient positioning is critical in radiotherapy (RT) to ensure effective treatment delivery and minimize harming surrounding healthy tissues. Vertebral misalignment during RT setup h...

Automatic 4D Lung PET-CT Segmentation Using Hybrid Deep Neural Network

Authors: Hongyi Jiang, Fang-Fang Yin

Affiliation: Duke University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
Imaging moving tissues using PET-CT can be difficult. Separating signal into phases during construction reduces signal count and increases influence of noise. Algorithms that use signal fr...

Automatic Tumor Segmentation and Catheter Detection from MRI for Cervical Cancer Brachytherapy Using Uncertainty-Aware Dual Convolution-Transformer Unet

Authors: Majd Antaki, Rohini Bhatia, Gayoung Kim, Yosef Landman, Junghoon Lee, Akila N. Viswanathan

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Physics and Advanced Development Elekta

Abstract Preview: Purpose: Brachytherapy is a standard radiation therapy approach for cervical cancer, which directly delivers radiation source to the tumor using catheters. Treatment planning requires identification o...

Biomechanically Informed Diagnostic-to-Synthetic CT Transformation for Expedited Radiation Therapy Planning

Authors: Liyuan Chen, Steve Jiang, Chenyang Shen

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center

Abstract Preview: Purpose: Delays in radiation therapy (RT) initiation caused by conventional CT simulation processes can hinder timely treatment delivery and patient outcomes. This study proposes a Virtual Treatment S...

Box-Prompt Zero-Shot Smart Segmentation in Radiation Oncology Using a SAM-Based Model: Smartsam

Authors: Kristen A. Duke, Samer Jabor, Neil A. Kirby, Parker New, Niko Papanikolaou, Arkajyoti Roy, Yuqing Xia

Affiliation: St. Mary's University, The University of Texas San Antonio, UT Health San Antonio

Abstract Preview: Purpose:
The Segment Anything Model (SAM) is a foundational box-prompt-based model for natural image segmentation. However, its applicability to zero-shot 3D medical image segmentation, particularl...

CT-Free PET Imaging: Synthetic CT Generation for Efficient and Accurate PET-Based Planning

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
PET is used in radiotherapy workflows for accurate target delineation. However, a separate CT scan is typically required for attenuation correction in PET imaging and for registering PET-d...

CT-on-Rails Longitudinal Image Quality Stability for Intensity Modulated Adaptive Proton Therapy

Authors: Austen N. Curcuru, Arash Darafsheh, Winter Green, Yao Hao, Baozhou Sun, Tiezhi Zhang, Tianyu Zhao, Xiandong Zhao

Affiliation: WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Washington University in St. Louis, University of South Florida, Baylor College of Medicine

Abstract Preview: Purpose: Intensity modulated proton therapy (IMPT) requires precise setup imaging due to the sharp dose gradients and rapid distal fall-off seen in proton therapy dose distributions. Additionally, onl...

Clinical Assessment of Synthetic CT in MR-Only Brain Radiotherapy

Authors: Ergun E. Ahunbay, Colette Gage, Abdul Kareem Parchur, Eric S. Paulson

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: AI-generated synthetic CT (sCT) images address challenges with prior sCT approaches, including atlas- and threshold-based methods. Commercial AI-based sCT tools have been introduced. This wor...

Commissioning Silicone Tissue-Compensating Bolus for Electron Beam Therapy

Authors: Carla D. Bradford, Linda Ding, Yansong Geng, Alan Hartford, I-Lin Kuo, Salvatore LaRosa, Joshua N Wancura

Affiliation: University of Massachusetts Chan Medical School

Abstract Preview: Purpose: When treating nasal skin cancers, electron beam radiotherapy dose distributions can be improved by using custom bolus to compensate for uneven surfaces. Here we describe our experience commis...

Comparative Evaluation of Nn-Unet Models for Radiotherapy Dose Prediction Using the Head and Neck Cancer Patients

Authors: Theodore Higgins Arsenault, Beatriz Guevara, Rojano Kashani, Raymond F. Muzic, Gisele Castro Pereira, Alex T. Price

Affiliation: University Hospitals Seidman Cancer Center, Case Western Reserve University Department of Biomedical Engineering

Abstract Preview: Purpose: Accurate dose prediction in radiotherapy is essential for treatment planning. This study evaluates four nnUnet-based models using the OpenKBP head and neck dataset: a baseline model (Model 1)...

Comparison of AI-Based and Ants for Longitudinal Deformable Image Registration in Head and Neck Cancer

Authors: Aditya P. Apte, Joseph O. Deasy, Jue Jiang, Nancy Lee, Sudharsan Madhavan, Nishant Nadkarni, Lopamudra Nayak, Harini Veeraraghavan, Wei Zhao

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To track early response to radiotherapy using digital twins, it is crucial to quantify tumor volume and mass changes. Traditional tumor detection methods, particularly in image registration, ...

Correcting for Lung Ventilation in Model-Based CT

Authors: Ryan Andosca, Igor Barjaktarevic, Peter Boyle, Jie Deng, Minji Victoria Kim, Michael Vincent Lauria, Daniel A. Low, Claudia R. Miller, Drew Moghanaki, Louise Naumann, Jack Neylon, Dylan P. O'Connell, Ricky R Savjani

Affiliation: Department of Pulmonology, University of California Los Angeles, University of California, Los Angeles, Department of Radiation Oncology, University of California, Los Angeles, UCLA, UCLA Radiation Oncology

Abstract Preview: Purpose: To develop a Hounsfield Unit ventilation-based correction method for use with model-based CT when used as a replacement for 4DCT.
Methods: The model-based CT we employ is termed 5DCT, whic...

Cross-Slice Attention for Unsupervised 3D Pelvic CBCT to CT Translation

Authors: Xu Chen, Jun Lian, Yunkui Pang, Pew-Thian Yap

Affiliation: University of North Carolina at Chapel Hill, Huaqiao University

Abstract Preview: Purpose: Unsupervised CBCT-to-CT translation in the pelvic region is essential for accurate radiotherapy delivery and adaptive image-guided interventions. However, current models for cross-modality tr...

Data-Driven Forward Projector for Optimization of the Proton Stopping Power Calibration in Treatment Planning Based on Sparse Proton Radiographies

Authors: Hector Andrade-Loarca, Ines Butz, Chiara Gianoli, Prof. Gitta Kutyniok, Jianfei Li, Katia Parodi, Prof. Vincenzo Patera, Angelo Schiavi, Prof. Ozan Öktem

Affiliation: Sapienza University of Rome, Department of Mathematics, Royal Institute of Technology, School of Computation, Information and Technology, Technische Universitaet Muenchen, Department of Medical Physics, Ludwig-Maximilians-Universität Mßnchen (LMU Munich), Department of Mathematics, Ludwig-Maximilians-Universität (LMU) Mßnchen, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen

Abstract Preview: Purpose: To explore and demonstrate the feasibility of accurate and fast prediction of the water equivalent thickness (WET) distribution of tissue traversed by a proton imaging pencil beam, aiming at ...

Data-Driven Gating in Ga-68 PET/CT: Impacts on Patient Selection and Dosimetry Predictions in Radiopharmaceutical Therapy

Authors: Zhuo Chen, Tinsu Pan, Allan Thomas

Affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, WashU Medicine, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Misregistration between data-driven gated (DDG)-PET and CT can limit the benefits of motion correction and improved localization and quantitation. DDG-CT offers a solution to these issues. He...

Deep Learning Aided Oropharyngeal Cancer Autoplanning

Authors: Mark Bowers, Gabriel Carrizo, Jimmy Caudell, Vladimir Feygelman, Kevin Greco, Christian Hahn, Jihye Koo, Kujtim Latifi, Fredrik Lofman, Jacopo Parvizi, Muqeem Qayyum, Caleb Sawyer

Affiliation: RaySearch Laboratories, Moffitt Cancer Center

Abstract Preview: Purpose: Head and neck (H&N) radiotherapy planning is complex, with multiple competing objectives. We endeavored to improve efficiency of planning by developing a deep learning (DL) model trained to p...

Deep Learning-Based Auto Segmentation of Oars in Head and Neck Radiation Therapy

Authors: Laila A Gharzai, Bharat B Mittal, Poonam Yadav

Affiliation: Northwestern Feinberg School of Medicine, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine

Abstract Preview: Purpose: Multiple studies have shown the increasing role of deep learning in segmenting regions of interest. This work presents the feasibility of auto-segmenting the critical structures for head and ...

Deep Learning-Based Dose Distribution Prediction for Automation of Treatment Planning

Authors: Yaspal Badyal, Rabten Datsang, Tianjun Ma, William Song

Affiliation: MVision AI, Virginia Commonwealth University

Abstract Preview: Purpose: Deep learning (DL)-based dose distribution predictions for prostate cancer show significant potential for OAR sparing compared to manually optimized treatment plans. We aim to generate clinic...

Deep Learning-Based Segmentation Using Cine Epid Images for Real-Time Tumor Monitoring

Authors: Fumiaki Komatsu, Shunsuke Moriya, Ryosuke Nakamura, Takeji Sakae, Toshiyuki Terunuma, Tetsuya Tomita

Affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Institute of Medicine, University of Tsukuba, Proton Medical Research Center, University of Tsukuba, Department of Radiology, University of Tsukuba Hospital

Abstract Preview: Purpose: To develop a deep learning (DL) model capable of accurately tracking lung tumors independent of beam angle variations.
Methods: A thoracic dynamic phantom simulating lung motion in the sup...

Deep Learning-Based Ventricular Auto-Segmentation for Dosimetric Analysis in Intraventricular Tumor SRS

Authors: John Byun, Juan J Cardona, Steven D Chang, Cynthia Fu-Yu Chuang, Xuejun Gu, Yusuke Hori, Hao Jiang, Fred Lam, Lianli Liu, Weiguo Lu, David Park, Erqi Pollom, Elham Rahimy, Deyaaldeen Abu Reesh, Scott Soltys, Gregory Szalkowski, Lei Wang

Affiliation: Department of Radiation Oncology, Stanford University, Department of Neurosurgery, Stanford School of Medicine, Department of Neurosurgery, Stanford University, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Intraventricular tumors pose significant challenges in neurosurgery due to their complex location. Therefore, brain SRS could be a better treatment option. At our institution, some patient...

Determination of HU Override for Small Metal Implants in Proton Therapy

Authors: Matthew Stephen Andriotty, Taoran Cui, Harold Y Hu, Ke Nie, Tan Phan, Xiao Wang, Ning J. Yue, Chengzhu Zhang

Affiliation: Rutgers Cancer Institute of New Jersey, Basis Scottsdale

Abstract Preview: Purpose: Metallic implants are often non-isocentric, and their exact volumes/orientations/shapes are difficult to capture and contour accurately on CT images even if that information is known beforeha...

Determining the Optimal CT Tube Voltage for Imaging Bone Structures in Radiotherapy.

Authors: Mohamed Bahaaeldin Mohamed Afifi, Nahla Nagy Ahmad Ataalla, Ahmed A. Eldib

Affiliation: Fox Chase Cancer Center, Radiological Sciences and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University.

Abstract Preview: Purpose: Optimizing CT imaging parameters is crucial for balancing radiation dose, contrast resolution, and accurate Hounsfield unit representation, particularly in radiotherapy treatment planning. Th...

Development and Validation of a Deep Learning-Based Auto-Segmentation Module for Vestibular Schwannoma

Authors: John Byun, Steven D Chang, Cynthia Fu-Yu Chuang, Xuejun Gu, Melanie Hayden Gephart, Yusuke Hori, Fred Lam, Gordon Li, Lianli Liu, Weiguo Lu, David Park, Erqi Pollom, Elham Rahimy, Deyaaldeen Abu Reesh, Scott Soltys, Gregory Szalkowski, Lei Wang, Xianghua Ye, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Neurosurgery, Stanford University, Department of Radiation Oncology, Stanford University, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: Accurate and automated delineation of vestibular schwannoma (VS) volume is crucial for disease management, as both treatment approaches (stereotactic radiosurgery and invasive surgery) and mo...

Development of a Comprehensive Thoracic Re-Irradiation Database and Investigation of Time-Dependent Dose-Recovery Dynamics for Toxicity Modeling

Authors: Victoria Doss, Tsion Gebre, Rachel B. Ger, Esi A Hagan, Elaina Hales, Russell K Hales, Xun Jia, Heng Li, Dezhi Liu, Todd R. McNutt, Meti Negassa, Anas Obaideen, Tinker Trent, K. Ranh Voong, Cecilia FPM de Sousa

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: As cancer care advances, more patients require re-irradiation, yet evidence-based data is lacking. This study aimed to develop a thoracic re-irradiation database and explore time-dependent re...

Development of a Visualization Tool for LET and Proton Spot Mapping for PB Treatment Planning

Authors: Chang Chang, Mohammad Kanber, Stephen Kenneth Northway

Affiliation: East Carolina University, California Protons Cancer Therapy Center, California Proton Cancer Therapy Center

Abstract Preview: Purpose:
Proton therapy treatment planning involves the consideration of unique physical quantities such as Linear Energy Transfer (LET) and spot location maps that do not exist in photon treatment...

Direct-to-Unit Dose Calculations for Stereotactic Radiosurgery on a C-Arm Linac with Modern on-Board Imaging Solutions

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Haley K Perlow, Alex T. Price, Atefeh Rezaei, Prashant Vempati, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: The HyperSight imaging feature on C-arm linacs(HS-CBCT) offers increased CT number accuracy over conventional on-board imaging. The C-arm geometry allows for noncoplanar treatments common to ...

Dual-Branch Attention-Driven Network for Enhanced Sparse-View CBCT Reconstruction Using Planning CT As Prior Knowledge

Authors: Xiaoyi Dai, Manju Liu, Weiwei Sang, Pulin Sun, Fan Xia, Zhenyu Yang, Fang-Fang Yin, Chulong Zhang, Rihui Zhang

Affiliation: Jiahui International Hospital, Radiation Oncology, Duke Kunshan University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
Current deep learning-based sparse-view CBCT reconstruction methods are prone to hallucinatory artifacts, as they rely on inferred image details that may not correspond to true anatomical ...

Dual-Domain Neural Network Cone-Beam CT Correction for Online Adaptive Proton Therapy

Authors: Daniel H. Bushe, Arthur Lalonde, Hoyeon Lee, Harald Paganetti, Brian Winey

Affiliation: Universite de Montreal, Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, University of Hong Kong

Abstract Preview: Purpose: Improving the precision and fidelity of daily volumetric imaging is essential for enabling adaptive proton therapy (APT). While cone-beam CT (CBCT) provides daily volumetric imaging, their ut...

Enhancing Synthetic Pelvic CT Images from CBCT Using Vision Transformer with Adaptive Fourier Neural Operators

Authors: Rashmi Bhaskara, Oluwaseyi Oderinde

Affiliation: Purdue University

Abstract Preview: Purpose: This study proposes a novel approach to overcoming CBCT image quality limitations by developing an improved synthetic CT (sCT) generation method based on a CycleGAN architecture using Vision ...

Evaluating the Capabilities of Hypersight CBCT for Advanced Dual-Energy CBCT Imaging in Online Adaptive Radiotherapy

Authors: Yi-Fang Wang, Yading Yuan

Affiliation: Columbia University Irving Medical Center, Department of Radiation Oncology, Columbia University Irving Medical Center

Abstract Preview: Purpose: HyperSight, the latest CBCT technology from Varian Medical Systems, integrates rapid 6-second data acquisition with advanced iterative reconstruction and upgraded hardware. Previous studies h...

Evaluation of Thoracic Direct Dose Calculation Using Truebeam Linac with Hypersight Imaging CBCT Solution

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Alex T. Price, Sagar Regmi, Atefeh Rezaei, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: To investigate the feasibility and accuracy of using a Hounsfield Unit(HU) calibrated cone-beam computed tomography(CBCT) for direct dose calculation in thoracic treatment settings. In combin...

FMEA for Direct to Unit Adaptive Radiotherapy

Authors: Haleem Azmy, Robbie Beckert, Farnoush Forghani, Dean Hobbis, Dan Hong, Hyun Kim, Eric Laugeman, Silpa Raju-Salicki, Domenic Sievert

Affiliation: Washington University in St. Louis School of Medicine, WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Washington University School of Medicine, Wash U Medicine, Washington University in St. Louis

Abstract Preview: Purpose: A novel radiation therapy (RT) workflow has recently emerged with the advent of online adaptive RT systems, direct-to-unit (DTU). DTU utilizes online adaptive platforms (MR and CT based) to o...

Fast Synthetic-CT-Free Dose Calculation in MR Guided RT

Authors: Claus Belka, Stefanie Corradini, George Dedes, Nikolaos Delopoulos, Christopher Kurz, Guillaume Landry, Ahmad Neishabouri, Domagoj Radonic, Adrian Thummerer, Niklas Wahl, Fan Xiao

Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, LMU Munich, Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO)

Abstract Preview: Purpose: In MR-guided online adaptive radiotherapy, MRI lacks tissue attenuation information necessary for accurate dose calculations. Instead of using deep learning methods to generate synthetic CT i...

Financial Viability Analysis of on-Table Simulation Enabled Halcyon Using Time Driven Activity-Based Costing

Authors: Xinyuan Chen, Geoffrey D. Hugo, Alex T. Price, Pamela Samson, Tianyu Zhao

Affiliation: University Hospitals Seidman Cancer Center, University of South Florida, Washington University School of Medicine, WashU Medicine

Abstract Preview: Purpose: This study evaluates the financial viability of on-table simulation (CBCTp) enabled Halcyon system in radiation therapy. By leveraging Time-Driven Activity-Based Costing (TDABC), the analysis...

Financial Viability of on-Table Simulation Enabled Halcyon System Using Time Driven Activity-Based Costing Analysis.

Authors: Xinyuan Chen

Affiliation: Washington University School of Medicine

Abstract Preview: Purpose: This study evaluates the financial viability of on-table simulation (CBCTp) enabled Halcyon system in radiation therapy. By leveraging Time-Driven Activity-Based Costing (TDABC), the analysis...

Follow-the-Leader Framework for Adaptable Target Segmentation in Radiotherapy

Authors: Mingli Chen, Xuejun Gu, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: This study introduces a novel template-guided deep learning framework for primary gross tumor volume (GTVp) segmentation, addressing challenges posed by diverse tumor types and enabling a uni...

Foundation Model-Augmented Learning for Automatic Delineation in Precision Radiotherapy

Authors: Xianjin Dai, PhD, Michael Gensheimer, Praveenbalaji Rajendran, Lei Xing, Yong Yang

Affiliation: Department of Radiation Oncology, Stanford University, Massachusetts General Hospital, Harvard Medical School

Abstract Preview: Purpose: Recent advances in the automatic delineation of radiotherapy treatment targets, which incorporate linguistic clinical data extracted by large language models (LLMs) into traditional visual-on...

Free-Breathing VMAT and IMRT Versus Deep Inspiration Breath- Hold 3D-CRT Techniques for Left-Breast Cancer: A Practical Solution for Developing Countries

Authors: Md. Yousuf Ali, Parvin Akhter Banu, Ehteshamul Hoque, Qazi Mushtaq Hussain, Md Jobairul Islam, Md. Abdul Mannan, Sadia Afrin Sarah, Mostafa Aziz Sumon, Ahammad Al Mamun Sweet, AFM Kamal Uddin

Affiliation: Labaid Cancer Hospital & Superspeciality Centre

Abstract Preview: Purpose: Radiotherapy for left-sided breast cancer can induce cardiac injury. Deep Inspiration Breath Hold (DIBH) is a technique that minimizes cardiac exposure during treatment. This study compares d...

GPU-Accelerated Beamlet and Full Dose Calculations for Efficient Radiation Therapy Planning

Authors: Girish Bal, Jan Kralj, Ayan Mitra, PhD, Ling Shao, Matjaz Subic, Yevgen Voronenko

Affiliation: RefleXion Medical, Cosylab

Abstract Preview: Purpose: This work enhances the efficiency of radiation therapy treatment planning by optimizing the beamlet dose matrix and full patient dose computations using GPU acceleration. The Collapsed-Cone C...

Generating Brain Pseudo-CT from PET-Only Images Using Deep Learning Method

Authors: Pouya Azarbar, Nima Kasraie, Mahsa Shahrbabki Mofrad, Peyman Sheikhzadeh

Affiliation: UT Southwestern Medical Center, Shahid Beheshti University of Medical science, Imam Khomeini Hospital Complex,Tehran University of Medical Sciences, Tehran University of Medical Science

Abstract Preview: Purpose: PET imaging become crucial in diagnosing and managing various diseases, but its key limitation is the lack of detailed anatomical information. Integrating CT-scans with PET images enhances cl...

Generation of Virtual Lung PET Images from CT Data Via Deep Learning for Accelerated Tumor Detection and Preliminary Diagnosis

Authors: Pouya Azarbar, Nima Kasraie, Peyman Sheikhzadeh

Affiliation: UT Southwestern Medical Center, Shahid Beheshti University of Medical science, Imam Khomeini Hospital Complex,Tehran University of Medical Sciences

Abstract Preview: Purpose: Positron Emission Tomography (PET) is crucial for diagnosing and monitoring diseases due to its functional imaging capabilities. However, its high cost, significant radiation exposure, and li...

Glandular Dose Map in Voxelized Phantoms across Advanced Breast Imaging Modalities Obtained from Monte Carlo Simulations

Authors: Rodrigo T Massera, Sofia Giaccone Thomaz, Alessandra Tomal, Giovanna Tramontin

Affiliation: Universidade Estadual de Campinas. Instituto de FĂ­sica Gleb Wataghin, Department of Imaging & Pathology, unit of Medical Physics & Quality Assessment, KU Leuven

Abstract Preview: Purpose: Monte Carlo simulations are increasingly used in breast dosimetry for their precision in estimating difficult-to-measure quantities, such as glandular dose. With ionizing radiation in breast ...

High-Quality Patchnet (HQ-PatchNet) for Synthetic CT Generation in Head & Neck Imaging

Authors: So Hyun Ahn, Chris Beltran, Byongsu Choi, Jeong Heon Kim, Jin Sung Kim, Bo Lu, Justin Chunjoo Park, Bongyong Song, Jun Tan

Affiliation: Mayo Clinic, Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Ewha Medical Research Institute, Ewha Womans University College of Medicine, UC San Diego, Yonsei University College of Medicine

Abstract Preview: Purpose:
Cone-beam computed tomography (CBCT) is widely used in IGRT for patient positioning but suffers from low resolution and poor soft tissue contrast. Synthetic CT (sCT) generated from CBCT ad...

Impact analysis of effective dose conversion factors from CT scanner models

Authors: Max Chen, Sean Marquardt, Ben Yang, Kai Yang

Affiliation: Cary Academy, Massachusetts General Hospital, Winchester High School

Abstract Preview: Purpose: To analyze the impact of scanner model variation on the effective dose conversion factor (“k-factor”), which is most commonly used for CT effective dose calculation.

Methods: The stand...

In-Vivo Image Quality of Head/Neck and CNS with an Advanced C-Arm Linac CBCT Solution

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Christian Erik Petersen, Alex T. Price, Atefeh Rezaei, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: CBCT is subject to more artifacts due to increased photon scatter, especially in areas of increased tissue heterogeneities compared to fan-beam CTs (FBCTs). Improved imaging panels combined w...

Incorporating Physicians’ Contouring Style into Auto-Segmentation of Clinical Target Volume for Post-Operative Prostate Cancer Radiotherapy Using a Language Encoder

Authors: Steve B. Jiang, Chien-Yi Liao, Dan Nguyen, Daniel Yang, Hengrui Zhao

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Post-operative radiotherapy for prostate cancer requires precise contouring of the clinical target volume (CTV) to account for microscopic disease that is invisible in the image. However, ...

Initial Comparison of 3D CBCT Performance: New Mobile C-Arm Vs. O-Arm Unit

Authors: Wendy Siman, Wei Zhou

Affiliation: University of Colorado Anschutz Medical Campus, School of Medicine

Abstract Preview: Purpose:
To compare the image quality and radiation dose of 3D cone-beam CT modes of a mobile C-arm and an O-arm unit for intraoperative imaging.
Methods:
A 50-Âľm tungsten wire was imaged at ...

Integrating Multiple Modalities with Pretrained Swin Foundation Model for Head and Neck Tumor Segmentation

Authors: Jue Jiang, Aneesh Rangnekar, Shiqin Tan, Harini Veeraraghavan

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Weill Cornell Graduate School of Medical Sciences

Abstract Preview: Purpose: Clinicians often use information from FDG-PET and CT to interpret and delineate gross tumor (GTVp) and nodal (GTVn) volumes for radiotherapy planning in head and neck (HN) cancer patients. He...

Integrating Neuroanatomic Knowledge in Clinical Target Volumes for Glioma Patients Using Deep Learning

Authors: Ali Ajdari, Thomas R. Bortfeld, Christopher Bridge, Gregory Buti, Marcela Giovenco, Fredrik Lofman, Gregory C. Sharp, Helen A Shih, Tugba Yilmaz

Affiliation: Massachusetts General Hospital, RaySearch Laboratories, Department Of Radiation Oncology, Massachusetts General Hospital (MGH), Massachusetts General Hospital & Harvard Medical School, Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: Defining radiation target volumes with accurate integration of the neuroanatomy is one of the major difficulties in designing glioma treatments. We developed a deep learning network for norma...

Investigate Deep-Learned MRI Reconstruction with Data Consistency Mechanism and Task-Informed Loss

Authors: Mark Anastasio, Hua Li, Zhuchen Shao

Affiliation: Washington University School of Medicine, University of Illinois Urbana-Champaign

Abstract Preview: Purpose: Ill-conditioned reconstruction problems in medical imaging, such as those arising from undersampled k-space data in MRI, can result in degraded image quality and clinical task-orientated perf...

Investigation of Metallic Artefact Reduction Capabilities of Hypersight Enabled Platforms

Authors: Harald Keller, Iymad Mansour, Jeff D. Winter

Affiliation: Princess Margaret Cancer Centre

Abstract Preview: Purpose: The growing number of adaptive therapy applications is motivating image segmentation and direct dose calculation on CBCT. The purpose of this investigation is to evaluate the recently release...

Investigation of the Diagnostic Quality of Chest X-Rays Simulated from CT

Authors: Matthew R. Hoerner, Allison Shields

Affiliation: Yale University School of Medicine, Yale University

Abstract Preview: Purpose: To investigate the quality and clinical utility of chest x-rays synthesized from CT scans (sCXR).
Methods: Five helical chest CT exams were chosen for evaluation: this cohort represented a...

Knowledge-Based Deep Residual U-Net for Synthetic CT Generation Using a Single MR Volume for Frameless Radiosurgery

Authors: Justus Adamson, John Ginn, Yongbok Kim, Ke Lu, Trey Mullikin, Xiwen Shu, Chunhao Wang, Zhenyu Yang, Jingtong Zhao

Affiliation: Duke University, Duke Kunshan University

Abstract Preview: Purpose:
To develop a knowledge-based deep model for synthetic CT (sCT) generation from a single MR volume in frameless radiosurgery (SRS), eliminating the need for CT simulation prior to the SRS d...

Lung-Equivalent Compressible Material As Core Component for a Miniaturized Breathing Phantom Prototype

Authors: Silvia Calusi, Lucia Cavigli, Alberto Dalla Mora, Laura Di Sieno, Giacomo Insero, Riccardo Lisci, Livia Marrazzo, Cosimo Nardi, Stefania Pallotta, Andrea Profili, Fulvio Ratto, Giovanni Romano, Michaela Servi, Immacolata Vanore, Yary Volpe

Affiliation: Italian National Research Council IFAC-CNR, Institute of Applied Physics, Department of Physics, Politecnico di Milano, Department of Agricultural Food and Forestry System, University of Florence, Medical Physics Unit, Azienda Ospedaliero-Universitaria Careggi, Department of Industrial Engineering, University of Florence, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence

Abstract Preview: Purpose: To develop a multi-purpose lung phantom prototype to replicate respiratory dynamics and morphological features observed in clinical radiological (CT and MR) imaging of lung parenchyma.
Met...

Medical Data Handler: A Research-Oriented Graphical User Interface for Dicom Processing, Image Analysis, and Data Management

Authors: Andrew R. Godley, Steve B. Jiang, Mu-Han Lin, Austen Matthew Maniscalco, Dan Nguyen, Yang Kyun Park

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Preparing DICOM datasets for research and education is challenging due to the complexity of the format and the necessity for patient-specific handling. Existing workflows demand substantia...

Multi-Organ Segmentation of Pelvic Cone-Beam Computed Tomography (CBCT) with Transformer Models to Enhance Adaptive Radiotherapy for Prostate Cancer

Authors: Ming Chao, Thomas Chum, Tenzin Kunkyab, Yang Lei, Tian Liu, Richard G Stock, Hasan Wazir, Junyi Xia, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai

Abstract Preview: Purpose:
This study aims to develop effective strategies for multi-organ segmentation of pelvic cone-beam computed tomography (CBCT) images based on transformer models to facilitate adaptive radiat...

Multi-Scale, Multi-Task Framework with Jacobian Descent for Multi-Plan Dose Prediction in Sequential Boost Radiotherapy

Authors: Steve B. Jiang, Mu-Han Lin, Yu-Chen Lin, Austen Matthew Maniscalco, Dan Nguyen, David Sher, Xinran Zhong

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, UT Dallas

Abstract Preview: Purpose:
Sequential boost radiotherapy (RT) poses a challenge in allocating dose across multiple plans while protecting organs at risk (OARs). Clinicians must decide whether OAR sparing should occu...

NA-Unetr: A Neighborhood Attention Transformer Network for Enhanced 3D Segmentation of the Left Anterior Descending Artery

Authors: Hassan Bagher-Ebadian, Ahmed I Ghanem, Joshua P. Kim, Chengyin Li, Rafi Ibn Sultan, Kundan S Thind, Dongxiao Zhu

Affiliation: Wayne State University, Department of Radiation Oncology, Henry Ford Health-Cancer, Detroit, MI and Alexandria Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Henry Ford Health

Abstract Preview: Purpose: Accurate segmentation of the Left Anterior Descending (LAD) artery in free-breathing 3D treatment planning CT is crucial for radiotherapy but remains challenging due to its small size, comple...

Nnae: Automating Anomaly Detection and Quality Assurance in Medical Image Segmentation

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Deep learning-based automatic medical image segmentation is increasingly employed in clinical practice, significantly reducing manual workload. However, verifying segmentation results rema...

Noise Sensitivity of Benchmark Whole-Body CT Segmentation Models: Totalsegmentator and Vista3D Performance on an Independent Dataset

Authors: Samuel L. Brady, Shruti Hegde, Alexander Knapp, Usman Mahmood, Joseph G. Meier, Elanchezhian Somasundaram, Zachary Taylor

Affiliation: Cincinnati Children's Hospital Medical Ctr, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Cincinnati Children's Hospital Medical Center, Cincinnati Childrens Hospital Med Ctr

Abstract Preview: Purpose:
To assess how two benchmark multi-organ CT segmentation models respond to varying image noise levels.
Methods:
This study utilized the pediatric CT dataset from The Cancer Imaging Ar...

Nomogram Based on Interpretable Multiregional Radiomics of Cone-Beam Breast CT and Clinicopathologic Features for Predicting FISH Status in HER2 2+ Breast Cancer to Differentiate HER2-Low from -Positive: A Multi-Center Study

Authors: Keyi Bian, Marco Caballo, Wenxiu Guo, Haijie Li, Jiao Li, Aidi Liu, Yue Ma, Ioannis Sechopoulos, Yafei Wang, Yaopan Wu, Zhaoxiang Ye, Yuwei Zhang, Yueqiang Zhu, Daan van den Oever

Affiliation: Radboud University Medical Center, Tianjin Medical University Cancer Institute & Hospital, Sun Yat-Sen University Cancer Center

Abstract Preview: Purpose: To develop and validate a nomogram integrating intra- and peritumoral radiomics of contrast-enhanced cone-beam breast CT (CE-CBBCT) and clinicopathologic features for predicting fluorescence ...

Optimization of the U-Net Model for the Radiation Dose Prediction in Lung Cancer RT Plans and Its Uncertainty Quantification

Authors: Ibtisam Almajnooni, Victor Cobilean, Milos Manic, Harindra Sandun Mavikumbure, Elisabeth Weiss, Lulin Yuan

Affiliation: Virginia Commonwealth University

Abstract Preview: Purpose: This study aims to optimize the 3D U-Net architecture for dose prediction in lung cancer radiation therapy (RT) plans, particularly in scenarios with limited clinical data, as well as to quan...

Patient-Specific Coronary Artery Habitat Model for Enhanced Cardiac Sparing

Authors: Blessing Akinro, Soumyanil Banerjee, Ming Dong, Carri K. Glide-Hurst, Prashant Nagpal, Chase Ruff, Nicholas R. Summerfield, Timothy P. Szczykutowicz

Affiliation: Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Departments of Radiology and Medical Physics, University Wisconsin-Madison, Department of Radiology, University of Wisconsin-Madison, Department of Computer Science, Wayne State University, Department of Human Oncology

Abstract Preview: Purpose: Radiation dose to coronary arteries (CAs) during thoracic radiotherapy (RT) is linked to cardiotoxicity. However, precise CA delineation for avoidance is limited by image quality and CA compl...

Prospective Organ-Level Dose Estimation in CT Imaging Using Scout-Net: A Comparison with Established Methods

Authors: Maria Jose Medrano, Grant Stevens, Liyan Sun, Justin Ruey Tse, Adam S. Wang, Sen Wang

Affiliation: Department of Radiology, Stanford University, GE HealthCare, Stanford University

Abstract Preview: Purpose: Patient exposure to ionizing radiation is a major concern in CT imaging. Size-specific dose estimation methods can prospectively estimate organ-level radiation doses based on patient sizes an...

Real-Time Fully Automated IMRT Planning without Optimization Process Using a Two-Step AI Framework

Authors: Daisuke Kawahara, Takaaki Matsuura, Yuji Murakami, Ryunosuke Yanagida

Affiliation: Hiroshima High-Precision Radiotherapy Cancer Center, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima

Abstract Preview: Purpose: In recent years, automation in radiation therapy planning using AI has gained significant attention to reduce the workload of treatment planners. Adaptive Radiation Therapy (ART), as a new fo...

Real-Time Output Gating and Fault Handling for an Uhdr Mobetron

Authors: Petr Bruza, David J. Gladstone, Lesley A Jarvis, Austin Sloop, Kevin J. Willy, Rongxiao Zhang

Affiliation: Thayer School of Engineering, Dartmouth College, Dartmouth Cancer Center, Dartmouth Health

Abstract Preview: Purpose:
Active beam monitoring and output-gated dosimetry are essential systems for safe and accurate radiation delivery. UHDR irradiators such as the Mobetron rely on pre-programmed regimes and t...

Sensitivity of CT Ventilation Imaging to Image Acquisition and Reconstruction Parameters: A Phantom Study

Authors: Hilary Louisa Byrne, Paul J. Keall, John Kipritidis, Jeremy Lim

Affiliation: Northern Sydney Cancer Centre, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney

Abstract Preview: Purpose:
Non-contrast CT ventilation imaging (CTVI) has been developed as a cost-effective and accessible alternative to PET/SPECT V/Q imaging for visualizing lung function. However, the sensitivit...

Simulating Realistic Digital Phantoms for Virtual Clinical Trials in Radiology and Radiation Oncology Using a Deep-Learning Based Conditional Denoising Diffusion Probabilistic Model (c-DDPM)

Authors: Matthew Brown, Yushi Chang, Jinhyuk Choi, William Silva Mendes, Lei Ren, Aman Sangal, William Paul Segars, Phuoc Tran, Hualiang Zhong

Affiliation: University of Maryland School of Medicine, Department of Radiation Oncology, University of Maryland School of Medicine, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Digital phantoms like XCAT are essential for imaging and treatment optimization in radiology and radiation oncology. However, the lack of realistic textures (HU distribution) in XCAT limits i...

Small but Mighty: A Lightweight and Computationally Efficient Model for Deformable Image Registration

Authors: Hengjie Liu, Dan Ruan, Ke Sheng, DI Xu

Affiliation: Physics and Biology in Medicine, University of California, Los Angeles, Department of Radiation Oncology, University of California, San Francisco, Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, Los Angeles

Abstract Preview: Purpose:
State-of-the-art deep learning-based deformable image registration often uses large, complex models directly adapted from computer vision tasks but achieves only comparable performance to ...

Streamlining Direct-to-Unit Clinical Set-Ups for Radiation Therapy

Authors: Lori Buchholtz, Alison Garda, Chris L. Hallemeier, Kathryn L. Kolsky, Han Liu, Joseph John Lucido, Marisa Schinter, Andrew J. Veres, Sara Walerak

Affiliation: Mayo Clinic

Abstract Preview: Purpose: The C_START initiative aims to streamline and simplify the Direct-to-Unit (DtU) clinical setup and treatment planning process for photon radiation therapy, particularly for emergent cases suc...

Streamlining Orthovoltage QA: Feasibility of IC Profiler Dosimetry and Workflow Optimization

Authors: Huixiao Chen, Zhe (Jay) Chen, MinYoung Lee, Sameer Taneja

Affiliation: Yale School of Medicine, Department of Therapeutic Radiology, Yale University School of Medicine

Abstract Preview: Purpose: Superficial radiation therapy uses low-energy x-rays to treat various types of cancers, including non-melanoma skin cancers, and dermatological conditions such as keloid scars, mycosis fungoi...

Task-Specific Deep-Neural-Network Architecture Optimization for CBCT Scatter Correction

Authors: Hoyeon Lee

Affiliation: University of Hong Kong

Abstract Preview: Purpose: Deep-learning approaches are widely investigated for Cone-Beam CT (CBCT) scatter correction to improve the quality of the linear-accelerator mounted CBCT. This study aims to optimize the deep...

Teaching an Old Dog New Tricks: Unlocking Hidden Potential in Existing Frameworks for Versatile Radiotherapy Applications

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
This work demonstrates how existing software, when creatively adapted, can address a wide range of clinical challenges. By focusing on data exploration and application-specific modificatio...

The European Colonial Legacy’s Influence on Modern-Day Access to Radiological Health Services in Sub-Saharan Africa

Authors: Daniela Branco, John M Bryant, Shalom Kpetsu, Ann T. Nguyen, Gage H. Redler, Peter Allan Sandwall, Eman Suliman, Charles R. Thomas, Joseph Weygand

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, University of South Florida Morsani College of Medicine, Alzahraa University Hospital, Dartmouth College, Moffitt Cancer Center, OhioHealth, Purdue University, University of California San Diego / California Protons, Department of Radiation Oncology, Moffitt Cancer Center

Abstract Preview: Purpose: Access to radiological health services in sub-Saharan Africa (sSA) remains extremely inadequate, with over 90% of the population in most countries lacking access to radiotherapy and facing si...

Time-Efficient Photon Plan Checks with Esapi-Based Software

Authors: Kevin Peter Risolo

Affiliation: University of Pennsylvania

Abstract Preview: Purpose: To quantify the improved efficiency of checking patient treatment plan MU by utilizing RadFormation’s ClearCalc script-based program.
Methods: A total of 58 patients planned for treatment ...

To Establish Local Diagnostic Reference Levels (DRLs) for Head and Neck Computed Tomography (CT) Exams in Abuja, Nigeria, and to Investigate the Performance of Brain Metastasis (BM) and Brain Lesion (BL) Segmentation Techniques Using U-Net Models.

Authors: Nuraddeen Nasiru Garba, Kalpana M Kanal, Abdullahi Mohammed, Rabiu Nasiru, Muhammad SHAFIU Shehu, Daniel Vergara, Joseph Everett Wishart

Affiliation: AHMADU BELLO UNIVERSITY, ZARIA, University of Washington

Abstract Preview: Purpose: To establish local Diagnostic Reference Levels (DRLs) for head and neck computed tomography (CT) exams in Abuja, Nigeria, and to investigate the performance of brain metastasis (BM) and brain...

Transformations of the Coordinate System for Monte Carlo Dose Calculations of Spot Scanning Proton Therapy

Authors: Hongyu Jiang

Affiliation: Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: This study presents a method for transforming coordinates from RayStation’s treatment planning system into the Monte Carlo (MC) coordinate system used in GEANT4 for dose calculations in spot ...

Transformer-Based Proton Dose Prediction with and without Diffusion Process

Authors: Jing Qian, Brandon Reber, David M. Routman, Satomi Shiraishi

Affiliation: Mayo Clinic

Abstract Preview: Purpose: The dose distribution in proton radiotherapy (PRT) is characterized by sharp gradients, posing a challenge for machine learning-based dose prediction. While denoising with diffusion processes...

Ultra-Sparse-View Cone-Beam CT Reconstruction Based Strictly-Structure-Preserved Deep Neural Network in Image-Guided Radiation Therapy

Authors: Guangjun Li, Ying Song, Huanan Tang, Tianxiong Wu, Qiuyi Ye, Wei Zhang

Affiliation: West China Second Hospital of Sichuan University, United Imaging Healthcare, West China Hospital of Sichuan University

Abstract Preview: Purpose:
To propose a general low-dose reconstruction model for ultra-sparse-view cone-beam CT (CBCT) and evaluate its clinical application in improving image quality and reducing radiation dose fo...

Uncertainties on Synthetic-CT Generation from CBCT: Another Layer of Complexity in Abdominal Adaptive Radiotherapy

Authors: Laura I. Cervino, Wendy B. Harris, Paulo Quintero, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To evaluate the impact of the prediction uncertainty from CBCT-based synthetic CT (sCT) generation in abdominal adaptive radiotherapy.

Methods: CT and CBCT images from 65 abdominal pat...

Uncertainty-Guided Cross-Domain Adaptation for Unsupervised Medical Image Segmentation

Authors: Yunxiang Li, Weiguo Lu, Xiaoxue Qian, Hua-Chieh Shao, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Curating high-quality, labeled data for medical image segmentation can be challenging and costly, considering the existence of various image domains with differing modalities/protocols. Cr...

Universal MR-to-Synthetic CT: A Streamlined Framework for MR-Only Radiotherapy Planning

Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Converting MR images to synthetic CT (MR2sCT) is highly desirable as it streamlines the radiotherapy treatment planning workflow. This approach leverages the superior soft tissue visibilit...