Authors: Mitya M. Barreto, Nichole A. Harris
Affiliation: Department of Radiology, University Hospitals Cleveland Medical Center
Abstract Preview: Purpose: To evaluate dosimeter dependence of measured AGD, and to develop a dosimeter independent method for evaluating the AGD, for CEDM exposures.
Methods: Three solid-state dosimeters (Raysafe-X...
Authors: Dale W. Litzenberg, Ikechi S Ozoemelam, Rowan Paplanus, Michael Pillainayagam, Donald A. Roberts
Affiliation: University of Michigan, Oregon Health & Science University
Abstract Preview: Purpose: Clinical linear accelerators use dual foil scattering systems designed to achieve large uniform fields (up to 25×25cm²), which can reduce beam fluence by up to 93% compared to the unmodified ...
Authors: Julien Bancheri, Jan P. Seuntjens
Affiliation: Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre & University of Toronto
Abstract Preview: Purpose: To obtain an analytical expression for the charge collection efficiency of parallel-plate ionization chambers in high dose-per-pulse (DPP) beams that takes into account the square pulse time ...
Authors: Jeremy T. Booth, Nicholas Hardcastle, Freeman Jin, Alicja Kaczynska, Paul J. Keall, Chandrima Sengupta
Affiliation: Northern Sydney Cancer Centre, Royal North Shore Hospital, Physical Sciences, Peter MacCallum Cancer Centre, Image X Institute, Faculty of Medicine and Health, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney
Abstract Preview: Purpose: An ESTRO survey reported that 71% of radiotherapy centers across 41 countries want to implement real-time image guided radiation therapy (IGRT) to improve patient outcomes. To address this gl...
Authors: Larry A. DeWerd, Sean Jollota, Karen Rex Pius Vincent
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison
Abstract Preview: Purpose: Absolute measurements, often used to establish primary standards, offer lower measurement uncertainty. For 192Ir high-dose-rate (HDR) brachytherapy, the interim primary standard for air-kerma...
Authors: Denis Bergeron, Ryan P Fitzgerald, Ravneet Kaur, Rao Khan
Affiliation: John Hopkins University, NIST Radiation Physics Division, Howard University, National Institute of Standards and Technology
Abstract Preview: Purpose: There is growing interest in short-lived alpha-emitting radionuclides for cancer therapy due to their ability to selectively target and destroy cancer cells while sparing healthy tissue. Howe...
Authors: Harsh Arya, Yan Chang, Yujie Chi, Varghese Anto Chirayath, Joshua Rajan, Pan Zui
Affiliation: University of Texas at Arlington, Department of Physics, University of Texas at Arlington
Abstract Preview: Purpose: In targeted alpha therapy (TAT), absorbed dose rates can vary significantly spatially and temporally, impacting therapeutic efficacy as well as carcinogenic potential. This study reports the ...
Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Marios Myronakis
Affiliation: Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory
Abstract Preview: Purpose:
Dual-layer kV imager (DLI) architecture enables the capability for single-shot dual-energy (DE) intrafraction imaging. As noise from individual DLI layers are primarily uncorrelated, simpl...
Authors: Philip Cutter, Mark D'Souza, Arman Sarfehnia
Affiliation: Toronto Metropolitan University, Sunnybrook Health Sciences Centre, Sunnybrook Health Science Center
Abstract Preview: Purpose: Water calorimetry (WC) serves as an important standard for measuring absorbed dose to water, an essential metric in radiation therapy. WC directly and absolutely quantifies energy deposition ...
Authors: Hungcheng Hank Chen, Laura A. Doyle, Helena Frisbie-Firsching, Amy S. Harrison, Jackson D Reeves, Lindsay B Romak, Jon Strasser
Affiliation: Christiana Care
Abstract Preview: Purpose: Brass mesh bolus (BMB) is a high-density woven metal mesh which is an excellent alternative to tissue equivalent bolus in photon beams, offering improved surface conformality. Unlike utilizat...
Authors: Mateb Ali Alghamwa, Haya Aljuaid, Siyong Kim, Tianjun Ma, William Song
Affiliation: Virginia Commonwealth University
Abstract Preview: Purpose: The integration of Plastic Scintillation Detectors (PSDs) into 0.35T MR-Linac systems represents a significant advancement in radiotherapy, offering substantial benefits due to their tissue-e...
Authors: Gulakhshan M Hamad, Sina Mossahebi, Yannick P. Poirier, Amit Sawant
Affiliation: University of Maryland School of Medicine, Maryland University Baltimore
Abstract Preview: Purpose:
The combination of ultra-high dose rate (UHDR) proton therapy, known for normal tissue sparing, with spatially-fractionated radiotherapy (SFRT), promising enhanced tumor control and tissue...
Authors: Chang Heon Choi, Yoonsuk Huh, Jin Jegal, Seonghee Kang, Jung-in Kim, Inbum Lee, Hyojun Park
Affiliation: Department of Radiation Oncology, Seoul National University Hospital
Abstract Preview: Purpose: This study evaluates SpekPy, a Python-based tool for modeling kilovoltage (kV) x-ray spectra, by comparing its calculated energy spectra, half-value layer (HVL), and air kerma with experiment...
Authors: Baozhu Lu, Timothy C. Zhu, Yifeng Zhu
Affiliation: University of Pennsylvania
Abstract Preview: Purpose: Cherenkov intensity can be quantitatively correlated to surface dose but need certain corrections for accurate dose measurements. This study aims to investigate the impact of incident beam an...
Authors: Ruirui Dong, Gernot Echner, Peter Haering, Clarence King, Carlos Murillo, Gavin Poludniowski, Nicholas Sammut, Joao Seco, Steffen Seeber, Maria Francesca Spadea, Elpida Theodoridou
Affiliation: KIT, Department of Physics and Astronomy, Heidelberg University, Karolinska Institutet, DKFZ, University of Malta
Abstract Preview: Purpose:
The goal is to develop the first benchtop X-ray FLASH system based on a conventional small animal irradiator. The small animal irradiator will be modeled using a Monte Carlo toolkit for bo...
Authors: Ana Laura Burin, Maysa Müller Ferreira Gesserame, David Alexander Urbina Leal, Ilca Marli Moitinho Amaral Medeiros, Silas Leonel Pereira Miranda, Thuany Corrêa Nogueira, Maria da Penha Alburquerque Potiens, Pedro Henrique Ricardo, Maria Eduarda Zaganin Rigo, Orlando Rodrigues, Priscila Santos Rodrigues, Wilmmer Alexander Arcos Rosero, Maria Elisa Chuery Martins Rostelato, Sabrina Spigaroli Sgrignoli, Ana Catarina Koka de Souza Silva, Cristhian Ferreira Talacimon, Paulo Victor dos Santos Tavares, Lara El Hajj Teodoro, Carlos Alberto Zeituni, José Neres de Almeida
Affiliation: IPEN - USP
Abstract Preview: Purpose: Perform three-dimensional dosimetry of radioactive gold nanoparticles (¹⁹⁸AuNPs) using Fricke xylenol gel (FXG), aiming to determine the dose distribution and evaluate the method's effectiven...
Authors: Thomas R. Bortfeld, Prof. Elisabetta De Bernardi, Tianxue Du, Beatrice Foglia, Chiara Gianoli, Takamitsu Masuda, Katia Parodi, Marco Pinto, Boon-Keng Kevin Teo, Yunhe Xie
Affiliation: Department Of Radiation Oncology, Massachusetts General Hospital (MGH), School of Medicine and Surgery, University of Milano-Bicocca, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, National Institutes for Quantum Science and Technology (QST), University of Pennsylvania, Department of Experimental Physics - Medical Physics, Ludwig-Maximilians-Universität (LMU) München
Abstract Preview: Purpose: The full potential offered by protons in clinical practice is limited by range uncertainties. One possibility for monitoring is through secondary prompt gammas (PG). PG emission along the pen...
Authors: Petr Bruza, David J. Gladstone, Austin Sloop, Rongxiao Zhang
Affiliation: Thayer School of Engineering, Dartmouth College, Dartmouth Health
Abstract Preview: Purpose: UHDR-specific probes are becoming available on the market but often demand high costs and long order times. The reduced sensitivity of these probes often imposes challenges when measuring con...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Renan Felix dos Santos, Gustavo Freire Pereira da Silva, Alessandra Tomal
Affiliation: University of São Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de Física Gleb Wataghin
Abstract Preview: Purpose: Evaluate the feasibility of a bench-top PCCT using Geant4 Monte Carlo simulations. The study applied the Geant4 framework on determining the electronic density of materials as a function of C...
Authors: Salman M. Arnab, Yves Chevalier, Samuel Gagné, Adrian F. Howansky, Luc Laperrière, Xiangyi Wu, Wei Zhao
Affiliation: Stony Brook Medicine, Analogic Canada
Abstract Preview: Purpose: A direct-indirect dual-layer flat-panel-detector (DI-DLFPD) is under development for patient motion artifact-free contrast-enhanced digital mammography (CEDM). DI-DLFPD comprises a direct fro...
Authors: María Fernández, Inés Flores, Nuria Montero, Manuel Ruiz, Francisco San Miguel
Affiliation: Hospital Central de la Defensa 'Gómez Ulla', Hospital Central de la Defensa "Gomez Ulla", CSVE, Hospital Central de la Defensa 'Gómez Ulla', CSVE
Abstract Preview: Purpose:
During external radiotherapy treatments in the prostate, there can be PTV movements between fractions and during each treatment fraction. In a typical prostate treatment in our institution...
Authors: Catherine Coolens, Janny Yeyoung Kim, Michael Milosevic, Noha Sinno
Affiliation: Princess Margaret Hospital, University of Toronto
Abstract Preview: Purpose: In solid tumors, Interstitial fluid pressure (IFP) acts as a barrier to molecular transport to the tumor center and serves as a predictor of cancer patients’ treatment responsiveness. The nov...
Authors: Ramin Abolfath, Alexander Baikalov, Stefan Bartzsch, Nolan M. Esplen, Alan Eduardo Lopez Hernandez, Emil Schueler
Affiliation: MD Anderson Cancer Center, PI Experimental Medical Physics, Institute of Radiation Medicine (IRM), Helmholtz Munich, Germany, Howard University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: FLASH radiation therapy (FLASH-RT) leverages ultra-high dose rates (UHDR) to spare normal tissue as compared to conventional (CONV)-RT while preserving tumor control; this is termed the FLASH...
Authors: Hongjing Sun, Weibing Yang, Timothy C. Zhu, Yifeng Zhu
Affiliation: University of Pennsylvania
Abstract Preview: Purpose: This study aims to compare the commissioning results of TrueBeam and Halcyon linear accelerators with Monte Carlo (MC) simulations conducted using TOPAS. The ultimate goal is to leverage MC s...
Authors: Mercy Iyabode Akerele, Yuni K. Dewaraja, Richard Laforest, Justin K. Mikell, Wendy Siman, Allan Thomas, Daniel Thorek
Affiliation: University of Michigan, Washington University School of Medicine in St. Louis, Washington University School of Medicine, University of Colorado Anschutz Medical Campus, School of Medicine, Washington University in St. Louis, Mallinckrodt Institute of Radiology, Washington University School of Medicine
Abstract Preview: Purpose: Post-therapy quantitative 90Y SPECT and PET measurements show ~25% lower activity than vendor-reported values for glass microspheres. We hypothesize this discrepancy is due to bremsstrahlung ...
Authors: Jason Ellsworth, Mark Mishra, Jason K Molitoris, Lei Ren, Dario B. Rodrigues, Paul Turner, Graeme Woodworth
Affiliation: University of Maryland School of Medicine, Department of Neurosurgery, University of Maryland School of Medicine, University of Maryland, Department of Radiation Oncology, University of Maryland School of Medicine, Pyrexar Medical
Abstract Preview: Purpose: Hyperthermia therapy (HT) involves increasing tumor temperatures to 40-44°C and is a potent radio- and chemosensitizer for treating solid tumors. Current clinical strategies to heat deep-seat...
Authors: Belen Juste, Choonsik Lee, Matthew Mille, Rafael Miró, Sergio Morato Rafet, Agustin Santos, Gumersindo Verdú
Affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Universitat Politècnica de València, Servicio de Radiofísica y Protección Radiológica, Consorcio Hospitalario Provincial de Castellón, National Cancer Institute
Abstract Preview: Purpose: To evaluate the differences in CT scan radiation dose estimation between personalized dose reconstruction, based on real patient CT images, and generalized phantom-based dose calculations.
Authors: Daniel Ball, Alex Dresner, Geoffrey S. Ibbott, Leonard H. Kim, Christopher Tyerech, Sebastián Vega
Affiliation: MD Anderson Cancer Center at Cooper, Cooper Medical School of Rowan University, The American Board of Radiology, Department of Radiation Oncology, University of Pennsylvania, Rowan University, Philips Healthcare MR Oncology
Abstract Preview: Purpose:
In vivo dosimetry is valuable to radiation therapy for its ability to report the actual dose received by patients but is currently limited to surface and intracavitary measurements, leavin...
Authors: Rafael Carballeira, Tianyuan Dai, David J. Gladstone, Philip Von Voigts-Rhetz, Rongxiao Zhang
Affiliation: Shandong Cancer Hospital, Dartmouth College, IntraOp, Thayer School of Engineering, Dartmouth College, University of Missouri
Abstract Preview: Purpose: To analyze phase space (PHSP) data generated for Mobetron in FLASH radiotherapy and assess key dosimetric characteristics, including the energy spectrum, scattering angle distribution, and pe...
Authors: Bryan Bednarz, Larry A. DeWerd, Sean Jollota, Ahtesham Ullah Khan, Ohyun Kwon, Jeff Radtke
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison
Abstract Preview: Purpose: The accurate quantification of absorbed dose is essential for alpha-emitting radionuclides used in radiopharmaceutical therapy (RPT). This study presents the first direct comparison of physic...