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Results for "fractionation schemes": 8 found

Advancing Flash Radiotherapy: Intercomparison of Parameters between Two Institutions to Optimize Clinical Applications.

Authors: Amir Abdollahi, Celine Karle, Michele M. Kim, Constantinos Koumenis, Andrea Mairani, Erato Stylianou Markidou

Affiliation: Heidelberg Ion-Beam Therapy Center - Department of Radiation Oncology, German Cancer Research Centre(DKFZ), University of Pennsylvania, Physics Dep. University of Cyprus

Abstract Preview: Purpose: The aim is to compare FLASH dose-rate RT generated with protons and carbon (HIT) and compare to protons (UPenn) to provide evidence for equipotency of FLASH vs. standard RT to tumor growth co...

Effect of Variation in the α/β of Cervical Cancer on Clinical Outcomes of Radiation Therapy

Authors: Dennis A. Cheek, Wei Luo, Cameron Thayer-Freeman, Brien Timothy Washington

Affiliation: UT Southwestern Medical Center, University of Kentucky, Department of Radiation Medicine, University of Kentucky

Abstract Preview: Purpose: To investigate the effect of variation in the α/β of cervical cancer on clinical outcome for cervix cancer patients treated with radiation therapy.
Methods: A distribution of experimentall...

Formulation of Equivalent Dose in 2-Gy Fractions (EQD2) Based on the Linear-Quadratic-Linear (LQL) Model from First Principles

Authors: Makunda Aryal, Qiongge Li, Sook Kien Ng, Christopher F. Njeh, Edwin Quashie, Senthamizhchelvan Srinivasan, Yun Wang

Affiliation: Indiana University Medical School, Memorial Health Care System, Indiana University, Inova Hospital, Indiana University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose: Linear-Quadratic-Linear (LQL) model is a modification of the traditional Linear-Quadratic model used in radiobiology to describe cell survival in response to radiation. The LQL model extends ...

HyperArcTM Automated Radiosurgery Planning Enables Accurate a Priori Isotoxic Prescription Dose Selection

Authors: Rex A. Cardan, Carlos E. Cardenas, John B Fiveash, Joel A. Pogue, Richard A. Popple, Farnaz Rahim Li, Rodney J. Sullivan, Natalie N. Viscariello, Christopher Willey

Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham

Abstract Preview: Purpose: vBrain radiosurgery toxicity-rate is estimated via clinically-relevant isodose volume (IDV) thresholds according to HyTEC (e.g., V12Gy≤10cc). HyperArcTM (HA) automated planning allows accurat...

Image-Guided Adaptive Proton Therapy for Head and Neck Cancer Using a Novel Gantry-Less System

Authors: Philip Blumenfeld, Jon Feldman, Yair Hillman, Michael Marash, Aron Popovtzer, Alexander Pryanichnikov, Shimshon Winograd, Marc Wygoda, Vered Zivan

Affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), P-Cure Ltd./Inc., Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem

Abstract Preview: Purpose:
Image-guided adaptive proton therapy (IGAPT) allows tailored dose adjustments to account for anatomical and physiological changes during treatment. Recent efforts have developed a cost-eff...

Influence of the α/ß Ratio on Dose Constraints in Radiotherapy of Prostate Cancer

Authors: Marwa Y. Abdel Tawwab, Amin E Amin, Abdullah M. ElSharif, Somaia Metwally Elsayed, Magdy M. Khalil

Affiliation: School of Applied Health Science, Badr University in Cairo (BUC), Cairo, Egypt, Medical Physics, Radiation Oncology Department, Faculty of Medicine, Ain Shams University, Medical Biophysics, Department of Physics, Faculty of Science, Helwan University

Abstract Preview: Purpose: Prostate cancer radiotherapy typically employs conventional fractionation schedules over approximately eight weeks. This study investigates the effect of variations in the α/β ratio on dose c...

Novel Approach to Improve Treatment Planning Process for Mixed Fractionation Schemes on ZAP-X

Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang

Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center

Abstract Preview: Purpose: Using mixed fractionation schemes is a common technique in treating CNS lesions. This article describes an innovative plan-and-split approach for more efficient planning on the ZAP-X and thus...

Optimizing Fractionation Schedules for De-Escalation Radiotherapy in Head and Neck Cancers Using Deep Reinforcement Learning

Authors: Zhongjie Lu

Affiliation: Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine

Abstract Preview: Purpose: Patients with locally-advanced head and neck squamous cell carcinomas(HNSCCs), particularly those related to human papillomavirus(HPV), often achieve good locoregional control(LRC), yet they ...