Authors: Pierre Gardair, Johnathan E Leeman, Claire Keun Sun Park, Atchar Sudhyadhom
Affiliation: Brigham and Women’s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Harvard Medical School
Abstract Preview: Purpose: Dose is a poor surrogate for radiobiological damage but no in vivo technology exists to directly measure damage such as DNA strand breaks and free radical generation (FRG). Recent advances in...
Authors: Fei Han, James M. Lamb, Michael Vincent Lauria, Daniel A. Low, Tessa Elizabeth Maurer, Danilo Maziero, Claudia R. Miller, Drew Moghanaki, Louise Naumann, Nicolas Viot
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, Siemens Healthineers, UCLA, University of California Los Angeles
Abstract Preview: Purpose: Patients with lung disease outside radiotherapy are barred from high dose protocols used for motion modeling, but MRI could offer no-dose alternatives. Image-based ventilation is a promising ...
Authors: Claire Keun Sun Park, Atchar Sudhyadhom, Veena Venkatachalam, Noah Warner
Affiliation: Harvard–MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School
Abstract Preview: Purpose: Modern radiotherapy achieves sub-millimeter spatial accuracy but fails to account for patient- and spatially-specific variations in biological response. Free radical generation (FRG), particu...
Authors: Hamid Abdollahi Nasehabad, Mehrangiz Amiri, Mohammad Reza Deevband, Faraz Kalantari, Milad Peer-Firozjaei, Ali Shabestani Monfared, Ehsan Tajikmansoury
Affiliation: Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Department of Radiology, University of British Columbia, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, 1. Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Abstract Preview: Purpose:
Targeted radionuclide therapy (TRNT) with 213Bi- labeled radiopharmaceuticals is a promising approach in targeted alpha and beta therapy for cancer. This study aims to assess double-strand...
Authors: Wesley S. Culberson, Larry A. DeWerd, Ahtesham Ullah Khan, Zachary James Welchel
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison
Abstract Preview: Purpose: Flattening filter free (FFF) linac beams exhibit a centrally peaked beam profile due to the forward-directed bremsstrahlung production from MeV electrons, leading to volume averaging effects ...
Authors: Hansong Bai, Peter Jermain, Xun Jia, Heng Li, Devin Miles, Daniel Sforza, Michael H. Shang, Daniel Robert Strauss, Keith Unger, Lingshu Yin
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, MedStar Georgetown University Hospital, Johns Hopkins University, Department of Radiation Medicine, MedStar Georgetown University Hospital
Abstract Preview: Purpose: To investigate DNA Double Strand Break (DSB) induced by FLASH proton irradiation in a repair-free plasmid DNA model under different free radical scavenging conditions in plateau and Bragg pea...
Authors: Yao Hao, Yuting Peng, Francisco Javier Reynoso, Tianyu Zhao, Xiandong Zhao
Affiliation: Varian, University of South Florida, Washington University School of Medicine, Washington University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose: Ultra-high dose-rate (FLASH) dose rate (> 40 Gy/s) may result in a radio-protective effect in healthy tissue compared with conventional dose rate (CDR). This effect has been observed in vivo ...