Authors: Hao Peng, Yajun Yu
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) is a novel ablative radiation dosing scheme developed by our institution. This study aims to establish a regression...
Authors: Jenghwa Chang, Kuan Huang, Lyu Huang, Jason Lima, Jian Liu, Farzin Motamedi
Affiliation: Northwell, Department of Computer Science and Technology, Kean University, Physics and Astronomy, Hofstra University, Hofstra University Medical Physics Program
Abstract Preview: Title: A Deep Learning Approach to the Prediction of Gamma Passing Rates in VMAT Radiotherapy Plans for Adaptive Treatment.
Purpose: This study aims to develop a deep learning algorithm to predict ...
Authors: Wenhua Cao, Xianjin Dai, PhD, Hadis Moazami Goudarzi, Gino Lim, Miaolan Xie, Lei Xing, Lewei Zhao
Affiliation: University of Chicago Booth School of Business, Department of Radiation Oncology, Stanford University, Department of Industrial Engineering, University of Houston, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Proton Arc Therapy (PAT) delivers a continuous dose of radiation during gantry rotation. 4Ο is a non-coplanar technique used for advanced proton therapy delivery. This work proposes a hybrid ...
Authors: Petr Bruza, Eric R. Fossum, Alexander Geiersbach, David J. Gladstone, Karthik Raj Venkatesan
Affiliation: Dartmouth College, Thayer School of Engineering, Dartmouth College
Abstract Preview: Purpose: Current Cherenkov imaging sensors rely on image intensifiers to generate sufficient signal for photon detection. While image intensifiers (IIs) exhibit good Cherenkov photon signal response, ...
Authors: Kai-Cheng Chuang, Oana I. Craciunescu, Christopher Kelsey, Joseph Kowalski, Nicole Larrier, Xinyi Li, Sheridan G. Meltsner, Anna E. Rodrigues, Yang Sheng, Qiuwen Wu
Affiliation: Duke University, Duke University Medical Center
Abstract Preview: Purpose: To clinically implement a Volumetric Modulated Arc Therapy (VMAT) procedure for Total Body Irradiation (TBI) with off-the-shelf tools.
Methods: Patient is treated on linac couch with a hyb...
Authors: Theodore Higgins Arsenault, Beatriz Guevara, Rojano Kashani, Raymond F. Muzic, Gisele Castro Pereira, Alex T. Price
Affiliation: University Hospitals Seidman Cancer Center, Case Western Reserve University Department of Biomedical Engineering
Abstract Preview: Purpose: Accurate dose prediction in radiotherapy is essential for treatment planning. This study evaluates four nnUnet-based models using the OpenKBP head and neck dataset: a baseline model (Model 1)...
Authors: Benjamin Haibe-Kains, Ruiyan Ni, Alexandra Rink
Affiliation: Department of Medical Biophysics, University of Toronto, University Health Network
Abstract Preview: Purpose: Accurate auto-segmentation for targets and organs-at-risk (OARs) using deep learning reduces the delineating time in radiotherapy. In high-dose-rate brachytherapy, specific clinical criteria ...
Authors: Daniel A. Alexander, Jeffrey D. Bradley, Steven J. Feigenberg, Cole Friedes, Casey Hollawell, William Levin, Maksym Sharma, Boon-Keng Kevin Teo, Ying Xiao, Nikhil Yegya-Raman, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology and Applied Sciences, Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: To investigate lung function changes following definitive chemoradiation dose using CT-derived measurements in patients with locally advanced NSCLC at 6-months post-treatment compared to pre-...
Authors: Nan Li, Yaoying Liu, Shouping Xu, Gaolong Zhang
Affiliation: Department of Radiation Oncology, School of Physics, Beihang University, School of physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Abstract Preview: Purpose: In intensity-modulated proton therapy (IMPT) for head and neck cancer, CBCT registration ensures accurate setup, minimizing dose errors. Unlike IMRT, IMPT plans directly define tumor volumes ...
Authors: Kuan Ling Chen, Jiajin Fan, Maduka M. Kaluarachchi, Wei Nie
Affiliation: Inova Schar Cancer Institute
Abstract Preview: Purpose: This study evaluates the impact of CBCT acquisition speed on the accuracy of moving target alignment during image-guided radiotherapy. Additionally, the influence of target motion speed and r...
Authors: Nobuki Imano, Daisuke Kawahara, Misato Kishi, Yuji Murakami
Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima University
Abstract Preview: Purpose: This study aims to develop a comprehensive Multi-score by integrating Radiomics-score (Rad-score), Gene-score derived from gene expression levels, and tumor environment Rad-score (TE-Rad-scor...
Authors: Himanshu Bhat, Bruce Lewis Daniel, Junghoon Lee, Michael B. Roumeliotis, Ehud J. Schmidt, Ravi Seethamraju, Khadija Sheikh, Pan Su, Akila N. Viswanathan
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Siemens Medical Solutions USA Inc., Stanford Medical School, Department of Cardiology, Johns Hopkins University
Abstract Preview: Purpose: To perform frequent MRI during EBRT and brachytherapy (BT) to evaluate RT-induced fibrosis and remnant tumor changes, identified using ultrashort echo-time (UTE) and multiparametric (mpMRI), ...
Authors: Kenneth L. Homann, Natalie A Lockney, Hong Zhang
Affiliation: Department of Radiation Oncology, Vanderbilt University Medical Center, Vanderbilt University Medical Center
Abstract Preview: Purpose: The aim of this study is to develop a treatment planning methodology utilizing liver functional imaging via contrast-enhanced Magnetic Resonance Imaging (MRI) in patients undergoing stereotac...
Authors: Bingqi Guo, Ping Xia
Affiliation: Cleveland Clinic
Abstract Preview: Purpose:
Spatially fractionated radiation therapy (SFRT) delivers a βGRIDβ or βlatticeβ of high and low doses to tumors to increase tumor control, minimize normal tissue damage, and preserve the im...
Authors: Adnan Jafar, Xun Jia, An Qin
Affiliation: Johns Hopkins University
Abstract Preview: Purpose: 3D whole-brain radiotherapy (WBRT) is widely used due to its simplicity and effectiveness. While modern treatment planning systems, like RayStation, offer automated Field-in-Field planning, p...
Authors: Rex A. Cardan, Carlos E. Cardenas, John B Fiveash, Joel A. Pogue, Richard A. Popple, Farnaz Rahim Li, Rodney J. Sullivan, Natalie N. Viscariello, Christopher Willey
Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham
Abstract Preview: Purpose: vBrain radiosurgery toxicity-rate is estimated via clinically-relevant isodose volume (IDV) thresholds according to HyTEC (e.g., V12Gyβ€10cc). HyperArcTM (HA) automated planning allows accurat...
Authors: Cecelia Brewington, Connor Edwards Miles All Leska-Kent, Kyrillos Grace, Katherine Hyde, Sabee Molloi, Shiva Mostafavi, Liqiang Ren, Alireza Shojazadeh, Justin Truong
Affiliation: Department of Radiology, UT Southwestern Medical Center, University of California, Irvine, University of Texas Southwestern
Abstract Preview: Purpose: To retrospectively assess image quality in coronary CT angiography (CCTA) using a patient-specific post-trigger delay (PTD) protocol, developed using half of the injection time plus a dispers...
Authors: Anupama Chundury, Hyejoo Kang, John C. Roeske, Iris A. Rusu
Affiliation: Loyola University Medical Center, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago
Abstract Preview: Purpose: To quantify the dosimetric impact of six degrees of freedom (6DoF) intrafractional errors on gross tumor volume (GTV) and planning target volumes (PTV) for single-isocenter multi-target stere...
Authors: Bryan Bednarz, John M. Floberg, Joseph B. Schulz, Jordan M. Slagowski
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Radiation Oncology, Stanford University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: Catheter placement for high-dose-rate brachytherapy (HDR BT) is clinician dependent and potentially suboptimal for delivering simultaneous integrated boosts to intraprostatic gross tumor volu...
Authors: Hassan Bagher-Ebadian, Anthony J. Doemer, Ryan Hall, Joshua P. Kim, Bing Luo, Benjamin Movsas, Humza Nusrat, Kundan S Thind
Affiliation: Department of Physics, Toronto Metropolitan University, Henry Ford Health
Abstract Preview: Purpose: This study investigates the development and feasibility of local LLM-based agents to automate radiotherapy treatment planning, aiming to improve planning efficiency and consistency, while pre...
Authors: Yang Sheng, Qingrong Jackie Wu, Qiuwen Wu, Xin Wu, Dongrong Yang
Affiliation: Duke University Medical Center
Abstract Preview: Purpose:
This study aims to leverage large language model (LLMs) to develop a human-in-the-loop agentic framework, enhancing the efficiency of treatment planning in radiotherapy.
Methods:
A L...
Authors: Smith Apisarnthanarax, Stephen R. Bowen, Sunan Cui, Jie Fu, Clemens Grassberger, Yulun He, Yejin Kim, Matthew J. Nyflot, Sharon Pai
Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Washington, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Department of Physics, University of Washington, University of Washington and Fred Hutchinson Cancer Center
Abstract Preview: Purpose: 99mTc-sulfur colloid SPECT imaging enables quantitative assessment of voxel-wise liver function in patients with hepatocellular carcinoma (HCC). Accurately predicting post-radiotherapy (RT) l...
Authors: Peng Dong, Lei Xing
Affiliation: Department of Radiation Oncology, Stanford University, Stanford University
Abstract Preview: Purpose: Volumetric Modulated Arc Therapy (VMAT) optimization is a complex, non-convex problem with numerous variables and intricate constraints. Traditional optimization methods often lack efficiency...
Authors: Jon Burns, Angela J Da Silva, Andrew Groll, Gopinath Kuduvalli, Manoj Narayanan, Jeffrey Schmall, Sanchit Sharma, Timothy Pok Chi Yeung
Affiliation: Reflexion Medical Inc,, RefleXion Medical
Abstract Preview: Purpose: Biology-guided radiotherapy uses positron emissions from FDG-avid tumor volumes to provide a of the planned prescribed dose with high accuracy. The purpose of this work is to characterize BgR...
Authors: Lars Ewell, Russell J. Hamilton
Affiliation: Banner University Medical Group, Bannerhealth
Abstract Preview: Purpose: To estimate the variability and predictability of radiation dose as a function of the planning target volume (PTV) size and the anatomical sites of head & neck, brain and prostate.
Methods...
Authors: Joseph Barbiere, Joseph Hanley, Brett Lewis, Jay Mistry, Alois M. Ndlovu, Roland Teboh
Affiliation: Hackensack University Medical Center, HUMC, Jersey Shore University Medical Center
Abstract Preview: Purpose:
Quantitative PET-CT can evaluate clinical response to radiotherapy. For tumors less than approximately 3cm partial volume effects due to the poor PET resolution makes accurate measurement ...
Authors: Ana Maria Barragan Montero, John A. Lee, Eliot Peeters, Romain Schyns, Edmond S. Sterpin, Sophie Wuyckens
Affiliation: UCLouvain, Universite Catholique de Louvain
Abstract Preview: Purpose:
Although the likelihood of a point being tumorous decreases with distance from the GTV, CTVs are still defined as binary masks. Recently, the concept of clinical target distribution (CTD),...
Authors: Jameson T. Baker, Sean T Grace, Cindy Pham, Michael A. Trager
Affiliation: Northwell
Abstract Preview: Purpose:
In VMAT planning, increasing complexity in MLC motion and modulation may improve dose distributions and OAR sparing while maintaining PTV coverage. However, increasing complexity can creat...
Authors: Avinash Mudireddy, Nathan Shaffer, Joel J. St-Aubin
Affiliation: University of Iowa
Abstract Preview: Purpose: This work demonstrates preliminary results in training a reinforcement learning (RL) network to perform VMAT machine parameter optimization.
Methods: We implemented a policy gradient RL al...
Authors: Michael Baine, Yang Lei, Yu Lei, Ruirui Liu, Tian Liu, Jing Wang
Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center
Abstract Preview: Purpose: Accurate 3D deformable registration of MRI and ultrasound (US) is essential for real-time image guidance during high-dose-rate (HDR) prostate brachytherapy. However, MRI-US registration of th...