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Results for "generated phantoms": 105 found

4D CBCT Dynamic Images Recovery Using a 4D Neural Network

Authors: Ziheng Deng, Yao Hao, Runping Hou, Deshan Yang, Jun Zhao, Yufu Zhou

Affiliation: Department of Radiation Oncology, Duke University, School of Biomedical Engineering, Shanghai Jiao Tong University, Washington University School of Medicine, Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine

Abstract Preview: Purpose: 4D CBCT has been developed to provide dynamic images for image-guided radiation therapy. However, as projection data are sorted into sparse and clustered phase-specific bins, 4D CBCT images a...

A Beagle Dog Mesh-Type Phantom for Application to Nuclear Medicine and Internal Dosimetry

Authors: Wesley E. Bolch, Natalia Estefania Carrasco-Rojas, Chansoo Choi, Robert Joseph Dawson, Aitor Gallastegui Menoyo, Rowan James Milner, Bangho Shin, Maria M. Von Chamier

Affiliation: University of Florida

Abstract Preview: Purpose: To develop a tetrahedralizable mesh-type phantom of a male beagle dog to later perform Monte Carlo radiation transport simulations and calculate organ doses using monoenergetic photons, elect...

A Clarification on the Bandwidth Difference Method for MRI B0 Homogeneity Assessment

Authors: Christina Brunnquell, Daniel Vergara, Joseph Everett Wishart

Affiliation: University of Minnesota, University of Washington

Abstract Preview: Purpose: To propose and validate a correction to the bandwidth difference method presented in Task Group Report No. 325 for quantifying static magnetic field homogeneity (ΔB0).
Methods: A clarifica...

A Deep Learning Approach to the Prediction of Gamma Passing Rates in VMAT Radiotherapy Plans for Adaptive Treatment.

Authors: Jenghwa Chang, Kuan Huang, Lyu Huang, Jason Lima, Jian Liu, Farzin Motamedi

Affiliation: Northwell, Department of Computer Science and Technology, Kean University, Physics and Astronomy, Hofstra University, Hofstra University Medical Physics Program

Abstract Preview: Title: A Deep Learning Approach to the Prediction of Gamma Passing Rates in VMAT Radiotherapy Plans for Adaptive Treatment.
Purpose: This study aims to develop a deep learning algorithm to predict ...

A Deep Learning Method for Direct Vmi Inference Using a Dual-Layer Radiotherapy Kv-CBCT Imager

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: A challenge for dual energy CBCT is that noise and residual errors in material decomposition steps can become amplified when forming low energy, high contrast virtual mono-energetic images (V...

A Dual Energy CT-Guided Intelligent Radiation Therapy Platform

Authors: Jiayi Chen, Manju Liu, Ning Wen, Haoran Zhang, Yibin Zhang

Affiliation: Department of Radiation Oncology, Ruijin Hospital, Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Duke Kunshan University, Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Abstract Preview: Purpose: This study introduces a novel Dual Energy CT (DECT)-Guided Intelligent Radiation Therapy (DEIT) platform designed to streamline and optimize the radiotherapy process. The DEIT system combines...

A Novel Integrated Framework for Rapid Automatic Calculation of Organ Absorbed Dose from kV-CBCT Imaging during Radiotherapy

Authors: Marios Myronakis, Kyriaki Theodorou

Affiliation: Medical Physics Department, Medical School, University of Thessaly

Abstract Preview: Purpose: The development of an integrated application framework for rapid, seamless, and automated calculation of absorbed organ dose for individual patients undergoing kV CBCT imaging over the course...

A Refined Model of Reference Mesh-Type Female Breast Model Vasculature and Glandular Structures for Internal Circulating Lymphocyte Dosimetry

Authors: Wesley E. Bolch, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Lazaro Fuentes Alfonso, Shreya P. Pathak, Julia D. Withrow

Affiliation: University of Florida

Abstract Preview: Purpose: To develop tetrahedral mesh-based tissue models within the breasts of the International Commission on Radiological Protection (ICRP) adult female mesh-type reference computational phantom (AF...

A Virtual 4DCT Generator Based on a Digital Phantom with Joint Cardiac and Respiratory Motions

Authors: Phillip Cuculich, Geoffrey D. Hugo, Xiwen Li, Michael T. Prusator, Clifford Robinson, Pamela Samson, Xue Wu

Affiliation: Washington University School of Medicine in St Louis, Washington University School of Medicine in St. Louis, University of Utah, WashU Medicine

Abstract Preview: Purpose:
For development of novel motion management methods it is useful to have a digital phantom capable of realistic simulation of respiratory 4DCT acquisition of the thorax, including cycle-to-...

Advancing Flash Radiotherapy: Intercomparison of Parameters between Two Institutions to Optimize Clinical Applications.

Authors: Amir Abdollahi, Celine Karle, Michele M. Kim, Constantinos Koumenis, Andrea Mairani, Erato Stylianou Markidou

Affiliation: Heidelberg Ion-Beam Therapy Center - Department of Radiation Oncology, German Cancer Research Centre(DKFZ), University of Pennsylvania, Physics Dep. University of Cyprus

Abstract Preview: Purpose: The aim is to compare FLASH dose-rate RT generated with protons and carbon (HIT) and compare to protons (UPenn) to provide evidence for equipotency of FLASH vs. standard RT to tumor growth co...

An Adaptive Non-Local Means Filtering Method for Denoising CBCT Images Under Low X-Ray Fluence Conditions

Authors: Cem Altunbas, Farhang Bayat

Affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Taussig Cancer Center, Cleveland Clinic

Abstract Preview: Purpose:
Low dose imaging and scatter rejection hardware in CBCT reduces X-ray fluence incident on the imager, increasing noise, causing photon starvation artifacts in CBCT images. In this work, we...

An Automated System for MRI Coil Performance Evaluation

Authors: Michael Cuddy, Samuel J. Fahrenholtz, Khushnood Hamdani, Saman Jirjes, Robert G. Paden, Jeremiah W. Sanders, William F. Sensakovic, Wolfgang Stefan, Jeffrey Xiao, Yuxiang Zhou

Affiliation: Mayo, Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Title: An automated system for MRI coil performance evaluation

Purpose: To develop an automated quality control (QC) system for MRI coils to assess element-level signal-to-noise ratio (SNR), ar...

An Image Registration-Based Motion Correction Procedure to Recover Joint Cardiac and Respiratory Motion from Respiratory 4DCT

Authors: Phillip Cuculich, Geoffrey D. Hugo, Xiwen Li, Michael T. Prusator, Clifford Robinson, Pamela Samson, Xue Wu

Affiliation: Washington University School of Medicine in St Louis, Washington University School of Medicine in St. Louis, University of Utah, WashU Medicine

Abstract Preview: Purpose: Stereotactic arrhythmia radiotherapy (STAR) requires compensation for both respiratory and cardiac motions of the heart. Respiratory 4DCT scans implicitly include cardiac motion and cycle-to-...

An Open-Access Toolkit to Generate Realistic CT and Low-Field MR Images Based on an Xcat Phantom

Authors: Debora de Souza Antonio, Romy Guthier, Konrad Pawel Nesteruk, Erno Sajo, William Paul Segars, Gregory C. Sharp, Atchar Sudhyadhom, Hengyong Yu

Affiliation: Massachusetts General Hospital, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Massachusetts General Hospital and Harvard Medical School, University of Massachusetts Lowell

Abstract Preview: Purpose: To develop an open-access toolkit for rapidly generating simultaneously realistic CT scans and low-field MR images of the abdominal region, based on patient data, while employing an XCAT phan...

Analysis of Noise Power Spectra in MR Parallel Imaging

Authors: Sulaiman D. Aldoohan, Gerardo Garcia

Affiliation: University of Toledo Medical Center

Abstract Preview: Purpose: To evaluate the noise power spectra (NPS) of images acquired using parallel imaging with varying acceleration factors in 1-D and 3-D spaces and to compare the level of the power of the noise ...

Assessment of Viscoelastic Changes in Ex Vivo Liver Tissue Using Pulsed Magnetomotive Ultrasound during Magnetic Hyperthermia

Authors: David Alejandro Collazos Burbano, Antonio Adilton Oliveira Carneiro, Paul L. Carson, Jose Eduardo Freire, Theo Zeferino Pavan, Joao Henrique Uliana, Nicholas Zufelato

Affiliation: University of SĂŁo Paulo, University of Michigan, University of Sao Paulo

Abstract Preview: Purpose: Develop a theranostic platform that integrates magnetic hyperthermia (MH), ultrasound, and magnetic nanoparticles (MNPs) to improve diagnosis, treatment, and monitoring of hyperthermia proced...

Automatic 4D Lung PET-CT Segmentation Using Hybrid Deep Neural Network

Authors: Hongyi Jiang, Fang-Fang Yin

Affiliation: Duke University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
Imaging moving tissues using PET-CT can be difficult. Separating signal into phases during construction reduces signal count and increases influence of noise. Algorithms that use signal fr...

BEST IN PHYSICS IMAGING: Dosimetric Impact of Iodinated Contrast Agent on Fibroglandular Tissue in Contrast-Enhanced Digital Mammography

Authors: Hannah Grover, Andrew J. Sampson

Affiliation: Oregon Health & Science University, UT Health San Antonio

Abstract Preview: Purpose: The goal of this work was to quantify the dosimetric impact of iodinated contrast on fibroglandular breast tissue to better inform clinical risk and benefit assessments when determining the m...

Backward Photon Monte Carlo Propagator (BPMCP): Proof of Concept of a Fully Physics-Driven SPECT Reconstruction

Authors: Alejandro Bertolet, Carlos Huesa-Berral, Victor V. Onecha

Affiliation: Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: Radioembolization for liver tumors using 90Y microspheres uses SPECT as confirmatory dosimetry, although 90Y is a pure ÎČ-emitter, and SPECT-imaging is only available through subsequent bremss...

CNN-Based Reconstruction for 3D Scintillation Dosimetry of Proton Pencil Beams

Authors: Sam Beddar, Jason Michael Holmes, Daniel G. Robertson, James J. Sohn, Ethan D. Stolen

Affiliation: Department of Radiation Oncology, Mayo Clinic, MD Anderson Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Department of Radiation and Cellular Oncology, University of Chicago

Abstract Preview: Purpose: Camera-based scintillation dosimetry incorporating large volumes have shown promise for fast and comprehensive evaluation of external beam treatment fields. While some efforts have been made ...

CT-on-Rails Longitudinal Image Quality Stability for Intensity Modulated Adaptive Proton Therapy

Authors: Austen N. Curcuru, Arash Darafsheh, Winter Green, Yao Hao, Baozhou Sun, Tiezhi Zhang, Tianyu Zhao, Xiandong Zhao

Affiliation: WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Washington University in St. Louis, University of South Florida, Baylor College of Medicine

Abstract Preview: Purpose: Intensity modulated proton therapy (IMPT) requires precise setup imaging due to the sharp dose gradients and rapid distal fall-off seen in proton therapy dose distributions. Additionally, onl...

Characterization of Image Intensified Cherenkov Cameras for Development of Direct CMOS-Based Detection Systems

Authors: Petr Bruza, Eric R. Fossum, Alexander Geiersbach, David J. Gladstone, Karthik Raj Venkatesan

Affiliation: Dartmouth College, Thayer School of Engineering, Dartmouth College

Abstract Preview: Purpose: Current Cherenkov imaging sensors rely on image intensifiers to generate sufficient signal for photon detection. While image intensifiers (IIs) exhibit good Cherenkov photon signal response, ...

Characterization of Novel Shielded and Unshielded Silicon Diode Detectors for Photon and Electron Dosimetry in Radiation Therapy

Authors: Mohamad Ahmad Alissa, Carson Brame, Damian Czarnecki, Olivier Evrard, Charbel A. Habib, Jeff Hildreth, Andy Murray, Andreas Schönfeld, Ann-Britt Schönfeld, David Towle, Gerd Wessing

Affiliation: CDT-West - Centrum fĂŒr Diagnostik und Therapie, Radiologie Vechta, Technische Hochschule Mittelhessen, MyMichigan Health, Sun Nuclear Corp., Mirion Technologies

Abstract Preview: Purpose: To characterize the performance of novel shielded and unshielded silicon diode detectors in relative photon and electron beam dosimetry.

Methods: The novel shielded and unshielded sili...

Characterizing the Stability of Upright CT for Proton Therapy

Authors: Brian Burger, Carri K. Glide-Hurst, John W. Hayes, Carson Hoffman, Minglei Kang, Jessica R. Miller, Jordan M. Slagowski, Yuhao Yan

Affiliation: Department of Human Oncology, University of Wisconsin-Madison, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Leo Cancer Care

Abstract Preview: Purpose: The combination of upright CT and patient positioner for particle therapy present tremendous potential for high precision IGRT and online adaptive radiation therapy (ART), where reliable CT p...

Checking of Sensitivity of Volumetric Modulated Arc Therapy Quality Assurance System with a Cavity Generation Method

Authors: Kaile Li, Esmail Parsai

Affiliation: Alexander T. Augusta Military Medical Center, Alexander T. Augusta Miliary Medical Center

Abstract Preview: Purpose: To evaluate the sensitivity of the portal dosimetry system with the Arc CHECK system at identical Volumetric Modulated Arc Therapy (VMAT) setup
Methods: An Arc CHECK system from Sun Nuclea...

Clinical Experience with an Independent Dose Calculation Software for ZAP-X Stereotactic Radiosurgery

Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang

Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center

Abstract Preview: Purpose: ZapMU is the first independent monitor unit check software freely available supporting ZAP-X. In this study, the clinical experience with ZapMU for independent second check of dose calculatio...

Combining Proton Flash and Spatially Fractionated Radiotherapy – Experimental and Simulation Based Dosimetric Characterization

Authors: Gulakhshan M Hamad, Sina Mossahebi, Yannick P. Poirier, Amit Sawant

Affiliation: University of Maryland School of Medicine, Maryland University Baltimore

Abstract Preview: Purpose:
The combination of ultra-high dose rate (UHDR) proton therapy, known for normal tissue sparing, with spatially-fractionated radiotherapy (SFRT), promising enhanced tumor control and tissue...

Compact Representation of External Beam Photon Phase Space Data Via Implicit Neural Representation Learning

Authors: Serdar Charyyev, Cynthia Fu-Yu Chuang, Veng Jean Heng, Lianli Liu, Lei Xing, Yong Yang

Affiliation: Department of Radiation Oncology, Stanford University

Abstract Preview: Purpose: To replace large finite-size photon phase space files with a compact neural network capable of generating an infinite number of particles.
Methods: Three separate models were developed to ...

Comprehensive Commissioning of an O-Ring-Shaped Image-Guided Radiotherapy System with a Gimbal-Mounted Linear Accelerator

Authors: Tetsuo Fukuda, Hideaki Hirashima, Kohei Kawata, Yukako Kishigami, Takashi Mizowaki, Mitsuhiro Nakamura, Yohei Sawada, Maika Urago

Affiliation: Kyoto University, kyotoUnivercity, Hitachi high-tech, Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University

Abstract Preview: Purpose: To present the comprehensive commissioning results of the O-ring shaped linac, OXRAY.
Materials and Methods: OXRAY enables a novel three-dimensional unicursal noncoplanar irradiation metho...

Comprehensive Evaluation of High-Performance Cone-Beam Computed Tomography on C-Arm and Ring-Gantry Linacs for Adaptive Radiation Therapy

Authors: Laura I. Cervino, Karen Episcopia, Hsiang-Chi Kuo, Sangkyu Lee, Seng Boh Gary Lim, Shih-Chi Lin, Grace Tang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: This study evaluated the performance of the HyperSight Cone-Beam Computed Tomography (CBCT) system on a TrueBeam C-arm LINAC (TB) and two Ethos ring-gantry LINACs (ES) for adaptive radiation ...

Computed Tomography Organ Dose Library Derived from Newly Developed Newborn-Infant-Toddler Computational Phantoms

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Adam Leon Kesner, Cameron B. Kofler, Juan Camilo Ocampo Ramos, Yitian Wang, Stefan Wehmeier

Affiliation: University of Chicago, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: To develop a slice-specific computed tomography (CT) organ dose library using Monte Carlo radiation transport simulations on a newly created set of newborn, infant, and toddler computational ...

Conformal Flash for Large Treatment Fields

Authors: Julien Forthomme, Carolina Llina Fuentes, Valentin Hamaide, Lucian Hotoiu, Rudi Labarbe, Rasmus Nilsson, Arnaud Pin, Francois Vander Stappen, Erik Traneus

Affiliation: RaySearch Laboratories AB, Ion Beam Applications SA

Abstract Preview: Purpose: Conformal FLASH achieves ultra-high-dose-rate (UHDR) proton therapy (>40 Gy/sec) by scanning a mono-energetic pencil beam through accessories (range shifter, Conformal Energy Modulator, apert...

Correcting for the Cherenkov-to-Dose Conversion for Tset Patients Using Monte Carlo Simulations

Authors: Baozhu Lu, Timothy C. Zhu, Yifeng Zhu

Affiliation: University of Pennsylvania

Abstract Preview: Purpose: Cherenkov intensity can be quantitatively correlated to surface dose but need certain corrections for accurate dose measurements. This study aims to investigate the impact of incident beam an...

Cross-Calibration and Comparison of CT Number to Electron Density Using Two Calibration Phantoms

Authors: Afrouz Ataei, Xinhui Duan, Andrew R. Godley, Mi-Ae Park, Mahbubur Rahman, Liqiang Ren, Chenyang Shen, Gary Xu

Affiliation: Department of Radiology, UT Southwestern Medical Center, UT Southwestern Medical Center, Rush University, Imaging Services, UT Southwestern Medical Center

Abstract Preview: Purpose:
Electron density (ED) phantoms are crucial for calibrating CT number (HU) to relative ED in treatment planning. This study evaluates the differences in HU-to-ED calibrations between two co...

Decreasing the Dependence of CT Number on the Position in the Field-of-View Using Photon Counting Detector CT

Authors: Yanle Hu, Shuai Leng, Cynthia H. McCollough, Maryam Sadeghian, Joe Swicklik

Affiliation: Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose: The dependence of CT number on position in the field-of-view (FOV) imposes challenges in radiotherapy treatment planning. This study aims to decrease this dependence using photon counting det...

Deep Learning-Based Segmentation Using Cine Epid Images for Real-Time Tumor Monitoring

Authors: Fumiaki Komatsu, Shunsuke Moriya, Ryosuke Nakamura, Takeji Sakae, Toshiyuki Terunuma, Tetsuya Tomita

Affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Institute of Medicine, University of Tsukuba, Proton Medical Research Center, University of Tsukuba, Department of Radiology, University of Tsukuba Hospital

Abstract Preview: Purpose: To develop a deep learning (DL) model capable of accurately tracking lung tumors independent of beam angle variations.
Methods: A thoracic dynamic phantom simulating lung motion in the sup...

Deformable Scintillator Array Dosimetry for In Vivo Volumetric Dose and Dose-Rate Validation of Uhdr Proton Therapy

Authors: Petr Bruza, Megan Clark, David J. Gladstone, Joseph Harms, Anthony E. Mascia, Brian W Pogue, Roman Vasyltsiv, Zhiyan Xiao, Rongxiao Zhang, Yongbin Zhang

Affiliation: Cincinnati Children's Proton Therapy Center, University of Missouri, Dartmouth College, Thayer School of Engineering, Dartmouth College, Washington University in St. Louis, University of Wisconsin - Madison

Abstract Preview: Purpose: With developing FLASH trials requiring diligent delivery monitoring, current proton therapy in-vivo dosimetry (IVD) cannot provide comprehensive verification, including dose and dose-rate vol...

Detector Physics-Incorporated Diffusion Denoising Models for Digital Breast Tomosynthesis with Dual-Layer Flat Panel Detectors

Authors: Alexander Bookbinder, Matthew Tivnan, Xiangyi Wu, Wei Zhao

Affiliation: Stony Brook Medicine, Massachusetts General Hospital

Abstract Preview: Purpose: To investigate and benchmark a system-adaptive diffusion-based digital breast tomosynthesis (DBT) denoising model for a direct-indirect dual-layer flat panel detector (DI-DLFPD) with a k-edge...

Determining the Effect of Motion during Gamma Knife Stereotactic Radiosurgery on Anterior and Posterior Lesions Using an Anthropomorphic Phantom

Authors: Guang-Pei Chen, Nitish Chopra, Juan A. Garcia-Alvarez, Mi Huang, Slade J. Klawikowski, Haidy G. Nasief, George A. Noid, Abdul Parchur, Eric S. Paulson, Christina M. Sarosiek, Christopher Schultz

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: During routine delivery of mask-based Gamma Knife (GK) SRS, motion is tracked via the position of a reflective sticker placed on the patient’s nose relative to two stationary reflectors on th...

Development of Cross-Platform Application for Radiation Contamination Assessment

Authors: Wesley E. Bolch, Lotem Buchbinder Shadur, Natalia Estefania Carrasco-Rojas, Chansoo Choi, Robert Joseph Dawson, Shaheen Dewji, John Francis, Emmanual Mate-Kole, Wyatt Smither, Yitian Wang

Affiliation: Georgia Tech, University of Florida, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology

Abstract Preview: Purpose: Develop a software application capable of assessing the radiation contamination of military service members and members of the general public for fast, on-site radiological triage. The softwa...

Development of Treatment Planning System for Carbon Ion Radiotherapy in Yonsei Cancer Center

Authors: Min Cheol Han, Chae-Seon Hong, Changhwan Kim, Dong Wook Kim, Hojin Kim, Jin Sung Kim, HO Lee, Sac Lee, Yongdo Yun

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine

Abstract Preview: Purpose: Carbon ion radiotherapy (CIRT) offers the advantage of a greater relative biological effectiveness (RBE) weighted dose, which must be integrated into the treatment planning system (TPS). This...

Development of a Robust 3D-Ultrasound (3DUS) Quality Assurance (QA) Framework for a Real-Time Needle-Tracking System in HDR GYN Brachytherapy

Authors: Diandra Ayala-Peacock, Lindsey Hendricks Bloom, Oana I. Craciunescu, Julie A. Raffi, Megan K. Russ, Ryan Sanford, Rajesh Venkarataman

Affiliation: Clinical Imaging Physics Group, Department of Radiology, Duke University Health System, Duke University Medical Center, Duke University, Eigen Health, Duke Univesity

Abstract Preview: Purpose: To establish a robust QA framework to characterize and ensure accuracy, reliability, and reusability of a transrectal ultrasound (TRUS)-based needle tracking system (NTS) for clinical HDR GYN...

Developments of a Low-Cost Multi-Target Winston-Lutz Phantom and Software for SRS Linac Machines

Authors: Nellie Brovold, Wenbo Gu, Huan Amanda Liu, Lin Ma

Affiliation: University of Pennsylvania, Mayo Clinic

Abstract Preview: Purpose: To develop a low-cost comprehensive QA phantom and software for single-iso multi-target SRS Linac machines. This phantom can perform 1) Winston-Lutz QA test for on-axis and off-axis targets, ...

Dosimetric Accuracy Evaluation of Brainlab Elements 4.0 Treatment Planning System

Authors: Bhuvaneswari Narayanan, Niko Papanikolaou, Daniel L. Saenz

Affiliation: UT Health San Antonio, University of Texas HSC San Antonio

Abstract Preview: Purpose: To evaluate dosimetric accuracy of Brainlab Elements (BLE) 4.0 treatment planning system (TPS) for linac based SRS and Spine SBRT treatment.
Methods: RT Safe cranial and thorax phantoms wi...

Dosimetric Evaluation of Radiation Treatment Planning Algorithms in IMRT and VMAT Techniques: Analysis with Central and Peripheral Lung Tumors

Authors: Sumanta Manna, Atul Mishra, Surendra Prasad Mishra, Kailash Kumar Mittal, Anoop Kumar Srivastava, Neha Yadav

Affiliation: Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Department of radiation Oncology, Apollomedics Super Speciality Hospitals, Department of Radiation Oncology, Uttar Pradesh University of Medical Sciences, Department of Radiation Oncology, Kalyan Singh Super Specialty Cancer Institute

Abstract Preview: Purpose: This study aimed to assess the dosimetric performance of Volumetric Modulated Arc Therapy (VMAT), step-and-shoot Intensity-Modulated Radiation Therapy (ss-IMRT), and dynamic Intensity-Modulat...

Dosimetric Evaluation of the Aldo Function for Multiple Brain Metastases in Automated Stereotactic Radiosurgery Treatment Planning

Authors: Hsiao-Mei Fu, Shih-Ming Hsu, Chia-Ting Lee, Shih-Hua Liu, Tsung-Yu Yen

Affiliation: National Yang Ming Chiao Tung University, Mackay Memorial Hospital

Abstract Preview: Purpose: The Automatic Lower Dose Objective (ALDO) is a unique function designed to achieve 98% relative coverage across all targets in automated SRS treatment planning (HyperArc planning). This study...

EBT4 Film Dosimetry and the Significance of the Œ Fwhm Rule for Gamma Knife Output Factors

Authors: Jingying Lin, Stevan Pecic, Strahinja Stojadinovic

Affiliation: University of Belgrade, The University of Texas Southwestern Medical Center

Abstract Preview: Purpose: This study aims to determine the magnitude of polarization-induced dosimetric error for EBT4 films at different scanning orientations, and to provide guidance on selecting appropriate regions...

Emulating Human Perception of Low-Dose CT Image Quality Via Deep Generative Models

Authors: Jongduk Baek, Jooho Lee, Adam S. Wang

Affiliation: Stanford University, Yonsei University

Abstract Preview: Purpose: Optimizing the balance between radiation dose and image quality in computed tomography (CT) is important for minimizing patient X-ray exposure while maintaining diagnostic accuracy. While rad...

Enhanced Surface Dose Accuracy in Proton Treatment Planning: Optimizing External Volume HU Thresholding.

Authors: Michael Butkus, Camilo M. Correa Alfonso, Olga M. Dona Lemus, James Arthur Perez-Sanchez

Affiliation: University of Miami

Abstract Preview: Purpose: Accurate skin dose calculation is essential for treating superficial lesions such as those of the breast, chest wall, and scalp. Clinical treatment planning systems often rely on approximatio...

Establishing Tumor Size-Dependent Contrast Requirements for Multi-Target Biology-Guided Radiation Therapy (BgRT)

Authors: Muhammad Ramish Ashraf, Girish Bal, Daniel Pham, Murat Surucu

Affiliation: RefleXion Medical, Department of Radiation Oncology, Stanford University School of Medicine, Stanford University

Abstract Preview: Purpose: To determine minimum target size and FDG contrast thresholds for reliable Biology-guided Radiation Therapy (BgRT) delivery using a systematic phantom study.
Methods: A custom 3D-printed ph...

Evaluating the Impact of Reconstruction Algorithm on Wide-Angle Digital Breast Tomosynthesis System Optimization for Microcalcification Detection

Authors: Xiaoyu Duan, Xinyu Hu, Runqiu Li, Xiang Li

Affiliation: Dukekunshan University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
Accurate detection of small-sized microcalcifications (ΌCalcs) (< 500 ”m) is critical for early breast cancer diagnosis, requiring optimal imaging systems and reconstruction algorithms. Ho...

Evaluation of Film and 3D Printed Patient-Specific Phantom for Minibeam Radiation Therapy (MBRT) Dosimetry

Authors: Darwin Abraham Garcia, Michael P. Grams, Scott C Lester, Maryam Mashayekhi, Douglas John Moseley, Robert W Mutter, Sean S Park, Chrystian Quintero Mateus

Affiliation: Mayo Clinic - Rochester, Mayo Clinic

Abstract Preview: Purpose: MBRT delivers sub-millimeter wide regions of high “peak” (~10s Gy) and low “valley” (~1 Gy) doses to treat cancer. MBRT commissioning is performed in flat, uniform plastic water. Thus, differ...

Evaluation of Hypersight CBCT Scanning Techniques for Motion Management in Online Adaptive Radiotherapy: A Comparative Study of Slow, Fast, and Averaged Scans

Authors: Fan Liu, Adam C. Riegel, Yi-Fang Wang

Affiliation: Columbia University Irving Medical Center

Abstract Preview: Purpose: HyperSight, Varian Medical Systems' latest CBCT technology, integrates rapid 6-second data acquisition with advanced iterative reconstruction, enabling precise real-time contouring and dose c...

Evaluation of Ion Chamber Performance and Suitability for Flash Proton Therapy Dosimetry

Authors: Seohyeon An, Yoonsun Chung, Seonghoon Jeong, Seongmoon Jung, Chae-Eon Kim, In Jung Kim, Sung Hun Kim, Se Byeong Lee, Sang-il Pak, Jong In Park

Affiliation: POHANG ACCELERATOR LABORATORY, Hanyang University, Korea Research Institute of Standards and Science (KRISS), Ilsan Paik Hospital, National Cancer Center, National Cancer Center Korea, Korea Research Institute of Standards and Science

Abstract Preview: Purpose: To evaluate the performance of three ion chambers—Advanced Markus (AMC), PinPoint, and Roos—under FLASH proton beam conditions and assess the response of the nozzle monitor chamber for their ...

Evaluation of Phosphorus-32 Source Uniformity Using Python Algorithm and Monte Carlo Simulation

Authors: Ana Laura Burin, Ilca Marli Moitinho Amaral Medeiros, Priscila Santos Rodrigues, Maria Elisa Chuery Martins Rostelato, Sabrina Spigaroli Sgrignoli, Ana Catarina Koka de Souza Silva, Carla Daruich Souza, Cristhian Ferreira Talacimon, Lara El Hajj Teodoro, Carlos Alberto Zeituni

Affiliation: IPEN - USP, IPEN - Instituto de Pesquisas Energéticas e Nucleares

Abstract Preview: Purpose: The uniform distribution of phosphorus-32 (32P) in beta sources is essential to ensure the accuracy of radiotherapy treatments, such as those for paravertebral cancer. This study evaluated th...

Evaluation of Plan Quality and Optimal Isocenter Arrangement for Total Marrow and Lymphoid Irradiation on a Ring-Gantry Linac with Dual-Layer Mlc Using the Knowledge-Based Planning Technique

Authors: Chunhui Han, An Liu, Anthony Magliari, Lesley Rosa

Affiliation: Office of Medical Affairs, Varian, A Siemens Healthineers Company, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: To evaluate the performance of a knowledge-based planning (KBP) optimization model for total marrow and lymphoid irradiation (TMLI) on a ring-gantry linac with a dual-layer MLC and to evaluat...

Evaluation of Target Localization Accuracy As a Function of CBCT Acquisition Speed

Authors: Kuan Ling Chen, Jiajin Fan, Maduka M. Kaluarachchi, Wei Nie

Affiliation: Inova Schar Cancer Institute

Abstract Preview: Purpose: This study evaluates the impact of CBCT acquisition speed on the accuracy of moving target alignment during image-guided radiotherapy. Additionally, the influence of target motion speed and r...

Evaluation of a Commercially Available Solution for Dose Verification Using Daily AI Generated Pseudo-CT from CBCT.

Authors: Chloe DiTusa, Panayiotis Mavroidis, Christopher W. Schneider, Sotirios Stathakis

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center, University of North Carolina

Abstract Preview: Purpose: To evaluate and compare dose calculation differences between Monaco and AdaptBox by TheraPanacea on AI-generated pseudo-CTs (pCTs) from a CBCT.

Methods: Dose calculations in water phan...

Evaluation of the Dosimetric Characteristics of Multi-Layers of Brass Mesh Bolus for Electron Treatment

Authors: Yunzhi Ma, Ling Zhuang

Affiliation: Northwestern Medicine

Abstract Preview: Purpose: Multiple layers of brass mesh bolus (RPD, Inc., Albertville, MN) may be needed to provide better body conformity and sufficient dose build up on patient surface during electron treatment. Thi...

Evaluation of the Imaging Performance of PET-Linac As Compared to a Diagnostic PET/CT System for Small Tumors

Authors: Muhammad Ramish Ashraf, Girish Bal, Daniel Pham, Murat Surucu

Affiliation: RefleXion Medical, Department of Radiation Oncology, Stanford University School of Medicine, Stanford University

Abstract Preview: Purpose: To systematically evaluate the relationship between Activity Concentration (AC) obtained from the RefleXion PET-Linac with the maximum standardized uptake value (SUVmax) derived from a diagno...

Feasibility of Using 68ga-PSMA for Biology-Guided Radiotherapy (BgRT) Treatment

Authors: Girish Bal, Thomas I. Banks, Bin Cai, Neil Desai, Aurelie Garant, Orhan Oz, Elizeva Phillips, Rameshwar Prasad, Chenyang Shen, Robert Timmerman

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: This study reports findings from the first-in-human imaging-only trial evaluating the feasibility of using the novel PET tracer 68Ga-PSMA-11 (Illuccix) to guide external beam radiotherapy on ...

Field Output Correction Factors of Novel Shielded and Unshielded Silicon Diode Detectors

Authors: Mohamad Ahmad Alissa, Carson Brame, Damian Czarnecki, Olivier Evrard, Charbel A. Habib, Jeff Hildreth, Andy Murray, Andreas Schönfeld, Ann-Britt Schönfeld, David Towle, Gerd Wessing

Affiliation: CDT-West - Centrum fĂŒr Diagnostik und Therapie, Radiologie Vechta, Technische Hochschule Mittelhessen, MyMichigan Health, Sun Nuclear Corp., Mirion Technologies

Abstract Preview: Purpose: To characterize field output correction factors of novel shielded and unshielded silicon diode detectors.
Methods: Novel shielded and unshielded Silicon Diode Detectors (SDD) were characte...

Free-Breathing Spirometer-Gated Proton Pencil Beam Scanning Delivery Maintains Tumor Coverage with Improved Organ-at-Risk Sparing: A Motion Phantom Validation

Authors: Uriel Aura, Qing Chen, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Meng Wei Ho, Sheng Huang, Minglei Kang, Stanislav Lazarev, Nancy Y Lee, Yang Lei, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Anna Zhai, Ajay Zheng

Affiliation: DYN'R Medical System, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Tianjin Medical University Cancer Institute&Hospital, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: Managing tumor motion during pencil beam scanning proton therapy remains challenging. This study investigated the feasibility and dosimetric benefits of Free-Breathing Respiratory-Gated Deliv...

GPU Accelerated Monte Carlo Simulation for Tset Dose Calculation

Authors: Veng Jean Heng, Jan P. Seuntjens, Timothy C. Zhu, Yifeng Zhu

Affiliation: Department of Radiation Oncology, Stanford University, Princess Margaret Cancer Centre & University of Toronto, University of Pennsylvania

Abstract Preview: Purpose: We have developed a GPU-accelerated Monte Carlo (MC) simulation to determine the cumulative dose distribution of patients undergoing Total Skin Electron Therapy (TSET) using the Stanford tech...

Generation of Patient-Specific Phantom for Head & Neck Proton Therapy Based on Xcat

Authors: Cheng-En Hsieh, Shen-Hao Li, Hsin-Hon Lin, Shu-Wei Wu, An-Ci Yang

Affiliation: Department of Medical Imaging and Radiological Sciences, Chang Gung University, Proton and Radiation Therapy Center, Chang Gung Memorial Hospital, Proton and Radiation Therapy Center, Chang Gung Memorial Hospital Linkou

Abstract Preview: Purpose:
The aim of this study is to develop a framework of generating patient-specific phantom tailored for head and neck proton therapy. From these phantoms, digital reference objects based on th...

Glandular Dose Map in Voxelized Phantoms across Advanced Breast Imaging Modalities Obtained from Monte Carlo Simulations

Authors: Rodrigo T Massera, Sofia Giaccone Thomaz, Alessandra Tomal, Giovanna Tramontin

Affiliation: Universidade Estadual de Campinas. Instituto de FĂ­sica Gleb Wataghin, Department of Imaging & Pathology, unit of Medical Physics & Quality Assessment, KU Leuven

Abstract Preview: Purpose: Monte Carlo simulations are increasingly used in breast dosimetry for their precision in estimating difficult-to-measure quantities, such as glandular dose. With ionizing radiation in breast ...

Imaging Preclinical Proton Flash Radiation Using a Small Animal PET System

Authors: Xun Jia, Heng Li, Wen Li, Devin Miles, Daniel Sforza, Lingshu Yin, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: FLASH therapy holds great potential to revolutionize radiotherapy by minimizing toxicities of normal tissues. The extraordinarily high dose rate of FLASH proton beam makes precise delivery to...

Impact of Tissue Heterogeneity on Proton LET and RBE Distributions: A Monte Carlo Study

Authors: Xiangli Cui, Wei Han, Jie Li, Lingling Liu

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences

Abstract Preview: Purpose: To investigate the influence of tissue heterogeneity on proton beam linear energy transfer (LET) and relative biological effectiveness (RBE) using nine RBE models. This study quantifies the i...

Impact of Tracking By Jaws or Mlc on Treatment Accuracy in Synchrony Modality for Tomohelical Technique

Authors: Mireille Conrad, Cédric De Marco, Marie Fargier-Voiron, Maud Jaccard, Oscar Matzinger, Anthony Nagy, Stéphane Nevesny, Nicolas Joel Lionel Perichon

Affiliation: Clinique De Genolier

Abstract Preview: Purpose: Real-time tracking is implemented on Radixact by detecting the target position with 2D-kV image either directly (for lung tumors), or indirectly (using fiducials as surrogates), and by adapti...

Impact of Translucent Sheet Bolus and Melanin Concentration on Recorded Optical Signal during Cherenkov Imaging in External Beam Radiation Therapy

Authors: Jacqueline M. Andreozzi, Savannah Decker, Diego Hernandez, Iman R. Washington

Affiliation: UC San Diego, Department of Radiation Oncology, Moffitt Cancer Center, University of South Florida, Moffitt Cancer Center

Abstract Preview: Purpose: Recent advances in external beam radiation therapy have begun to explore the utility of Cherenkov radiation imaging as a beam delivery visualization tool. When sheet bolus is used during trea...

Improved SNR and Estimation Accuracy for Deuterium-MRI Acquired with Chemical Shift Imaging at 7 Tesla

Authors: Muhammed AR Anjum, Andrew J. Fagan

Affiliation: Mayo Clinic

Abstract Preview: Purpose:
This study describes a novel post-processing method to boost image SNR for deuterium-MRI acquired using chemical shift imaging (CSI) at 7T. Deuterium MRI via exogenous administration of a ...

Improvement of Spine Phantom for MR Imaging of the Spine

Authors: Richard Dortch, Thammathida Ketsiri, Zhiqiang Li, Shiv P. Srivastava

Affiliation: Barrow Neurological Institute, Dignity Health Cancer Institute, St. Joseph's Hospital & Medical Center

Abstract Preview: Purpose: Imaging the spinal cord post-surgery is challenging due to metal surgical implants, which induce signal loss and geometric distortions. Together, this hinders the visualization of the spinal ...

In-Vivo Dosimetry in Positron-Guided Radiation Therapy

Authors: Davide Brivio, Erno Sajo, Ryan Williams, Piotr Zygmanski

Affiliation: University of Massachusetts Lowell, Brigham and Women's Hospital, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School

Abstract Preview: Purpose: To develop a non-invasive 3D in-vivo dosimetry tool exploring the relationship between positron annihilations and dose per voxel using Monte Carlo simulation. The Positron Guided Radiation Th...

Initial Phantom Studies Towards Implementation of Sequential Dual Energy CBCT on an Adaptive Radiotherapy Linac Platform

Authors: James M. Balter, Alexander Moncion, Ikechi S Ozoemelam

Affiliation: University of Michigan

Abstract Preview: Purpose: Sequential dual-energy cone beam computed tomography (DE-CBCT) integrated with an online adaptive platform could potentially improve soft tissue visualization for more accurate anatomical del...

Intra-Organ Blood Vessel Mapping in Mice for Improved Pre-Clinical Radiation Dosimetry

Authors: Daylin Barroso, Chris Beekman, Wesley E. Bolch, Natalia Estefania Carrasco-Rojas, Robert Joseph Dawson, Walter Murfee, Harald Paganetti, Andrew Robert Sforza, Julia D. Withrow

Affiliation: Massachusetts General Hospital - Harvard Medical School, Massachusetts General Hospital, University of Florida

Abstract Preview: Purpose: To develop methods for quantifying the interaction of radiation with blood in the mouse whole body (MOBY) phantom for dosimetric applications. The most important of these are modeling the dis...

Investigating Microcalcification Detectability in a Static Breast Cone Beam CT Via Monte Carlo Simulation

Authors: Ahad Ollah Ezzati, Xiaoyu Hu, Xun Jia, Youfang Lai, Kai Yang, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Massachusetts General Hospital, Johns Hopkins University

Abstract Preview: Purpose: Gantry motion and patient breathing during a breast cone beam CT (bCBCT) scan is one of the major challenges for microcalcification (ÎŒCalcs) detection. By deploying a large number of individu...

Lesion Detection in Contrast Enhanced Cone Beam Breast CT with a Photon Counting Detector: A Monte Carlo Study

Authors: Ahad Ollah Ezzati, Xiaoyu Hu, Xun Jia, Youfang Lai, Kai Yang, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Massachusetts General Hospital, Johns Hopkins University

Abstract Preview: Purpose: Contrast-enhanced breast cone-beam computed tomography (bCBCT) provides high-resolution, 3D imaging of breast tissues with improved differentiation between normal and abnormal tissues. Curren...

Matching CT Numbers between a Photon-Counting CT and an Energy-Integrating Detector CT: A Phantom Study

Authors: Afrouz Ataei, Xinhui Duan, Mi-Ae Park, Liqiang Ren

Affiliation: Department of Radiology, UT Southwestern Medical Center, UT Southwestern Medical Center, Rush University

Abstract Preview: Purpose:
Photon-counting CT (PCCT) has become commercially available recently, offering significant potential to enhance patient care. However, it also introduces unique challenges. One such challe...

Micro-Ultrasound Guided Focal Prostate Radiotherapy: Development and Testing of a Novel Device.

Authors: Kevin Barker, David Jeffrey Contella, Chandima Edirisinghe, Aaron Fenster, Douglas A Hoover, Elizabeth Huynh

Affiliation: Robarts Research Institute, University of Western Ontario, London Health Sciences Center, Department of Radiation Oncology, London Health Sciences Centre

Abstract Preview: Purpose: We aim to develop a system that integrates micro-ultrasound into focal prostate cancer radiotherapy. This requires developing a mechatronic stepper capable of performing motorized rotation of...

Off- Axis Winston Lutz on C-Arm Linac Using in-House Phantom

Authors: Colton Baley, Bhuvaneswari Narayanan, Niko Papanikolaou, Daniel L. Saenz

Affiliation: UT Health San Antonio, Texas Oncology, University of Texas HSC San Antonio

Abstract Preview: Purpose: To evaluate the accuracy of off-axis winston lutz (WLT) for linac based stereotactic radiosurgery (SRS) treatments using in-house phantom.

Methods: Traditional WLT that uses cone and s...

On Designing a Vascular Flow Phantom for Contrast-Enhanced Ultrasound Imaging

Authors: Kevin M Brom, Josep Chorro Bas, RosaAnna Chorro Bas, Andres Climent Rubio, Jaydev K. Dave, Tobias Kummer, Larissa Shiue, Donald J Tradup

Affiliation: Mayo Clinic, Prehospital Critical Care Training Group

Abstract Preview: Purpose: To design and evaluate the functionality of a vascular flow phantom for contrast-enhanced ultrasound imaging (CEUS).

Methods: A microcontroller-generated signal was amplified by a cust...

Optimizing Low-Dose Imaging Parameters for Dual-Energy Cone-Beam Computed Tomography in Image-Guided Radiation Therapy

Authors: Sebastien A. Gros, Hyejoo Kang, Andrew Keeler, Luke Layman, Jason Patrick Luce, Ha Nguyen, John C. Roeske

Affiliation: Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago

Abstract Preview: Purpose:
This study aims to optimize virtual monoenergetic (VM) images obtained from dual-energy (DE) cone-beam computer tomography (CBCT) protocols for Image-Guided Radiation Therapy (IGRT). The o...

Organ Dose Estimation from Successive CBCT Imaging for Patients Undergoing Radiation Therapy for Prostate Cancer

Authors: Panagiotis Iliopoulos, Marios Myronakis, Kyriaki Theodorou

Affiliation: Medical Physics Department, Medical School, University of Thessaly

Abstract Preview: Purpose: To estimate individualized absorbed dose at Organs at Risk (OARs) from kV Cone Beam CT (CBCT) imaging in the pelvic area, prior radiotherapy, and assess excess risk for secondary malignancies...

Patient-Specific Quality Assurance in SBRT Treatments Using 3D Polymer Gel Dosimetry

Authors: Esteban Arzaga-Barajas, Paola Jazmin Guadarrama Huerta, Jose Alejandro Jimenez, Guerda Massillon-JL, Maria Adela Poitevin-ChacĂłn, Alejandro Rodriguez-Laguna

Affiliation: UNAM, Medica Sur

Abstract Preview: Purpose: To perform patient-specific quality assurance (PSQA) tests for four SBRT treatments of patients diagnosed with vertebral, ilium, pelvic lymph node and lung tumors.
Methods: MAGIC gel consi...

Physics-Informed Neural Network for In Vivo Dosimetry during Proton Therapy Using Protoacoustic Tomography

Authors: Kristina Bjegovic, Yong Chen, Gilberto Gonzalez, Yankun Lang, Lei Ren, Leshan Sun, Liangzhong Xiang, Yifei Xu

Affiliation: University of Maryland School of Medicine, University of California, Irvine, University of Oklahoma Health Sciences Center, University of Oklahoma Health Science Center

Abstract Preview: Purpose: Proton therapy is becoming an increasingly popular choice for cancer treatment due to its precision, reduced side effects, and effectiveness. While dosimetry is fundamental to the success of ...

Posterior-Mean Diffusion Model for Realistic PET Image Reconstruction

Authors: Osama R. Mawlawi, Yiran Sun

Affiliation: RICE University, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Conventional PET reconstruction methods often produce noisy images with artifacts due to data/model mismatches and inconsistencies. Recently, deep learning-based conditional denoising diffusi...

Predicting Reactive Oxygen Species Generated through Photoactivation of Targeted Laser Therapy in-Silico

Authors: David Alcorta, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, Mark Oldham, Victoria J. P. Radosova

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center

Abstract Preview: Purpose: This study attempts to simulate the activation of targeted photodynamic molecules using visible laser light and characterize the direct Reactive Oxygen Species (ROS) generated by Cherenkov an...

Proton Minibeam Radiotherapy: Commissioning, Treatment Planning, and Delivery

Authors: Stephen M Corner, Daiki Hara, Jiasen Ma, Robert W Mutter, Mark D. Pepin, Nicholas B. Remmes, Hok Seum Wan Chan Tseung

Affiliation: Mayo Clinic - Rochester

Abstract Preview: Purpose: Proton minibeam radiotherapy (pMBRT) is a form of spatially fractionated radiation therapy leveraging submillimeter beams to improve the therapeutic ratio. We report on collimator design, com...

Quantification of Wet Towel As Bolus on Skin Dose for VMAT Partial Breast Irradiation

Authors: Haiqa Arain, Ping Xia, Zhexuan Zhang

Affiliation: Cleveland Clinic

Abstract Preview: Purpose: To quantify water contents and thickness of wet towel (as a flexible bolus) on curved surface dose for partial breast irradiation.

Methods: Two VMAT partial breast plans (3000 cGy in 5...

Radiochemical Monte Carlo Model to Investigate the Oxygen Impacts on Radical Yields Under Proton Flash Irradiation

Authors: Yao Hao, Yuting Peng, Francisco Javier Reynoso, Tianyu Zhao, Xiandong Zhao

Affiliation: Varian, University of South Florida, Washington University School of Medicine, Washington University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose: Ultra-high dose-rate (FLASH) dose rate (> 40 Gy/s) may result in a radio-protective effect in healthy tissue compared with conventional dose rate (CDR). This effect has been observed in vivo ...

Simulating Realistic Digital Phantoms for Virtual Clinical Trials in Radiology and Radiation Oncology Using a Deep-Learning Based Conditional Denoising Diffusion Probabilistic Model (c-DDPM)

Authors: Matthew Brown, Yushi Chang, Jinhyuk Choi, William Silva Mendes, Lei Ren, Aman Sangal, William Paul Segars, Phuoc Tran, Hualiang Zhong

Affiliation: University of Maryland School of Medicine, Department of Radiation Oncology, University of Maryland School of Medicine, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Digital phantoms like XCAT are essential for imaging and treatment optimization in radiology and radiation oncology. However, the lack of realistic textures (HU distribution) in XCAT limits i...

Single Plane Positioning Tracking Proton and Helium Pencil Beam Radiographs: Phantom Study

Authors: Anahita Bakhtiari Moghaddam, Don F. DeJongh, Ethan DeJongh, Jennifer Hardt, Oliver JĂ€kel, Lukas Martin, Alexander Pryanichnikov, Joao Seco, Christina Stengl, Niklas Wahl

Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), ProtonVDA LLC, Department of Physics and Astronomy, Heidelberg University, Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT)

Abstract Preview: Purpose:
To evaluate the feasibility and performance of single-plane position tracking for proton and helium pencil beam radiography using a prototype imaging system, with the goal of providing a c...

Sources of Variability in Evaluating Ultrasound Imaging Performance Using Randomly-Distributed Hypoechoic Sphere Phantom

Authors: Cristel Baiu, Zheng Feng Lu, Dufan Wu, Baihui Yu

Affiliation: University of Wisconsin, Massachusetts General Hospital, University of Chicago

Abstract Preview: Purpose: IEC TS 62791:2022 specified a clinically meaningful and quantitative framework for evaluating diagnostic ultrasound performance by measuring the lesion signal-to-noise ratio (LSNR) using rand...

Streamlined Calibration of Mosfet Dosimeters for Radixact Systems: Addressing Angular Dependence and Beam Profile Challenges

Authors: Guang-Pei Chen, Renae Conlin, Juan A. Garcia-Alvarez, Kirk Morris, Haidy G. Nasief, Eenas A. Omari, Eric S. Paulson

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Cumulative dose limits make replacing and calibrating Metal Oxide Semiconductor Field Effect dosimeters (MOSFET-d) used for in-vivo dosimetry a common clinical task. Calibration protocols for...

Synthetic CT Generation from a Cycle Diffusion Model Based Framework for Ultrasound-Based Prostate HDR Brachytherapy

Authors: Michael Baine, Charles Enke, Yang Lei, Yu Lei, Ruirui Liu, Su-Min Zhou

Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center, Department of Radiation Oncology, University of Nebraska Medical Center

Abstract Preview: Purpose: This study presents a framework for generating synthetic CT images using a Cycle Diffusion model, which can be utilized to enhance needle conspicuity in ultrasound-guided prostate HDR brachyt...

Synthetic Spheres: Ultrasound Image Quality Assessment with a Uniform Phantom

Authors: Ted Lynch

Affiliation: Sun Nuclear, a Mirion Medical Company

Abstract Preview: Purpose: A novel ultrasound quality assurance method is presented that constructs “synthetic spheres” at arbitrary locations within the image frame by combining correlation length measurements from a ...

Task Specific Image Quality Assessment Using Spectral Photon-Counting CT.

Authors: Azza Mohamed Ahmed, Nadine Francis, Osama Khan, Nabil Maalej, Aamir Raja, Briya Tariq

Affiliation: Khalifa University

Abstract Preview: Purpose: The study aims to evaluate the task-specific diagnostic performance of spectral photon-counting CT (SPCCT) using application-specific phantoms.
Methods:
Parameters such as linearity res...

The Z Dimension Matters: 3D Noise Power Spectrum of a Clinical Photon Counting Detector CT System

Authors: Frank F. Dong, Megan C. Jacobsen, Ke Li, Xinming Liu, Humberto Monsivais, John Rong

Affiliation: Purdue University, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To investigate the noise characteristics of a clinical photon counting detector CT (PCD-CT) system along axial and through-plane (Z) dimensions using 3D NPS measurements.
Methods: This stu...

Time and Energy-Encoded CT Reconstruction

Authors: Shusen Jing, Qihui Lyu, Dan Ruan, Ke Sheng, Qifan Xu

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Conventional computed tomography (CT) measures the collective attenuation of primary photon fluence and then reconstructs the 3D images without using the timing information of individual phot...

Treatment Planning System for Uhdr Mobetron: Refinement and Validation of Phase Space Data Input

Authors: Rafael Carballeira, Tianyuan Dai, David J. Gladstone, Philip Von Voigts-Rhetz, Rongxiao Zhang

Affiliation: Shandong Cancer Hospital, Dartmouth College, IntraOp, Thayer School of Engineering, Dartmouth College, University of Missouri

Abstract Preview: Purpose: To analyze phase space (PHSP) data generated for Mobetron in FLASH radiotherapy and assess key dosimetric characteristics, including the energy spectrum, scattering angle distribution, and pe...

Universal Range Modulators for Flash Proton Therapy: 3D Printing of Stackable Variable Density Units

Authors: Eric S. Diffenderfer, Lei Dong, Alejandro Garcia, Wenbo Gu, Michele M. Kim, Alexander Lin, Kai Mei, Peter B. Noël, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou

Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania

Abstract Preview: Purpose: We present a novel 3D-printed range-modulating devices with spatially modulated density for FLASH particle therapy. By varying density distributions, spread-out Bragg peaks(SOBPs) can be gene...

Validating a Pre-Existing CT HU-to-Mass Density Curve for Direct Dose Calculation on High Quality Cbcts

Authors: Casey E. Bojechko, Tricia Chinnery, Grace Gwe-Ya Kim, Xenia Ray

Affiliation: University of California San Diego

Abstract Preview: Purpose: To evaluate the use of a calibration curve generated from the CT simulator for direct dose calculation on cone beam computed tomography (CBCT) images taken with the on-board imaging system. T...

Validation of Synthetic CT-Based Online Monitoring for Adaptive Proton Therapy

Authors: Ozgur Ates, Chin-Cheng Chen, Chia-Ho Hua, Matthew J. Krasin, Thomas E. Merchant

Affiliation: St. Jude Children's Research Hospital

Abstract Preview: Purpose: To validate the use of synthetic CTs generated from CBCT images for online monitoring, ensuring accurate and reliable daily plan quality assessments in adaptive proton therapy (APT).
Metho...

Validation of a Simulation Tool and in-Silico Assessment of Low Contrast Detectability for Super-Resolution Deep Learning Reconstruction

Authors: Naruomi Akino, Kirsten Lee Boedeker, Ilmar Hein, Akira Nishikori, Daniel W Shin

Affiliation: Canon Medical Systems Corporation, Canon Medical Research USA

Abstract Preview: Purpose: To validate a simulation tool using physics-based image quality metrics in both phantom and patient data, and to assess the low contrast detectability (LCD) of Super Resolution-Deep Learning ...

dosimetric Characterization of Tungsten Eye Shields Using Monte Carlo Simulation

Authors: Omer Abdulaziz Ali, Robin Hill, Nathan Huntelerslag

Affiliation: Waikato Hospital, Hamilton, New Zealand, Central Coast Cancer Centre, Gosford, Australia

Abstract Preview: Purpose: Characterizing transmission through eye shields is essential to understanding dose distribution in underlying tissues. This study aims to utilize Monte Carlo (MC) simulations to model and cha...