Search Submissions 🔎

Results for "immune suppression": 4 found

A Framework for Automated Selection of Dose-Volume Objectives to Improve Radiation-Induced Immune Suppression (RIIS)-Related Overall Survival (OS) Following Chemo-Radiotherapy

Authors: Gabriel Lucas Andrade de Sousa, Einsley-Marie Janowski, Cam Nguyen, Krishni Wijesooriya

Affiliation: Department of Radiation Oncology, University of Virginia, Department of Physics, University of Virginia

Abstract Preview: Purpose: Optimizing radiation therapy (RT) to spare the immune system may improve Overall Survival (OS) in cancer patients. This study develops a computational algorithm to identify optimal dose-volum...

Lymph Node Dose Is Associated with Immune Suppression and Poor Overall Survival in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

Authors: Ryan Gentzler, Xin He, James Larner, J.T. Morgan, Cam Nguyen, Wendy Stewart, Krishni Wijesooriya, Grant Williams

Affiliation: Department of Physics, University of Virginia, Department of Radiation Oncology, University of Virginia, Division of Hematology & Oncology, Department of Medicine, University of Virginia

Abstract Preview: Purpose: Some recent studies have shown Overall Survival (OS) of advanced-stage lung cancer patients treated with chemo-radiation therapy (CRT) is correlated with heart dose [1-5], while in other stud...

Radio-Immune Response Model for the Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR)

Authors: Young-Bin Cho, Robert Timmerman

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Cleveland Clinic

Abstract Preview: Purpose: Immunologically hot (MC38) and cold (LLC) tumor in mouse were treated with radiation and/or immunotherapy agent for the study of Personalized Ultrafractionated Stereotactic Adaptive Radiother...

The Analysis of the Bifurcation from Immune-Limited to Immune-Escape Mode in Tumor Size

Authors: Young-Bin Cho, Jacob Scott, Nara Yoon

Affiliation: Adelphi University, Cleveland Clinic

Abstract Preview: Purpose: The immune system plays a critical role in determining cancer prognosis. Based on our prior study (Cho et al., 2023) about the bystander effect induced by immune responses in spatially design...