Authors: Mitya M. Barreto, Nichole A. Harris
Affiliation: Department of Radiology, University Hospitals Cleveland Medical Center
Abstract Preview: Purpose: To evaluate dosimeter dependence of measured AGD, and to develop a dosimeter independent method for evaluating the AGD, for CEDM exposures.
Methods: Three solid-state dosimeters (Raysafe-X...
Authors: Wesley E. Bolch, Chansoo Choi, Robert Joseph Dawson, Bangho Shin, Yitian Wang
Affiliation: University of Florida
Abstract Preview: Purpose: The skeleton plays a critical role in dosimetry, containing red bone marrow (RBM) and bone endosteum (BE), which are closely linked to radiation-induced leukemia and bone cancer. While severa...
Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Marios Myronakis
Affiliation: Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory
Abstract Preview: Purpose:
Dual-layer kV imager (DLI) architecture enables the capability for single-shot dual-energy (DE) intrafraction imaging. As noise from individual DLI layers are primarily uncorrelated, simpl...
Authors: Ivan L. Cordrey, Dharmin D. Desai, Ellis Lee Johnson
Affiliation: Cumberland Medical Center - Cancer Center, University of Kentucky, Varian Advanced Oncology Solutions
Abstract Preview: Purpose: HyperArc (HA) is known to produce a high quality SRS plan. Adding Surface Area Informed Optimization (SAIO) to HA has been shown to improve plan quality metrics R50% and the Conformality Inde...
Authors: Majd Antaki, Rohini Bhatia, Gayoung Kim, Yosef Landman, Junghoon Lee, Akila N. Viswanathan
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Physics and Advanced Development Elekta
Abstract Preview: Purpose: Brachytherapy is a standard radiation therapy approach for cervical cancer, which directly delivers radiation source to the tumor using catheters. Treatment planning requires identification o...
Authors: Zahra Ahmadi Ganjeh, Stefan Both, Peter Dendooven, Jeffrey Free, Brian Zapien Campos
Affiliation: Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Particle Therapy Research Center (PARTREC), Department of Radiation Oncology, University Medical Center Groningen, University of Groningen
Abstract Preview: Purpose: Positron emission tomography (PET) has been investigated for range monitoring in intensity-modulated proton therapy (IMPT), but real-time feedback been limited due to the focus on long-lived ...
Authors: Giacomo Avesani, Matthew D Blackledge, Silvia Bottazzi, Alison Tree, Nina Tunariu
Affiliation: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Institute of Cancer Research, The Royal Marsden NHS Foundation Trust
Abstract Preview: Purpose: To evaluate changes in median apparent diffusion coefficient (ADC) within metastatic oligoprogressing lesions from prostate cancer treated with stereotactic body radiotherapy (SBRT) and compa...
Authors: Michael Burke, David J. Carlson, Yiu-Hsin Chang, Huixiao Chen, Zhe (Jay) Chen, Emily A. Draeger, Dae Yup Han, Vanessa Hill, Ann-Teresa Jasman, John Kim, Svetlana Kuznetsova, MinYoung Lee, Daniel Longo, Henry S. Park, Adam Shulman, Lauren Tressel, Weili Zhong
Affiliation: Department of Therapeutic Radiology, Yale University School of Medicine
Abstract Preview: Purpose:
The complexity of biology-guided radiotherapy (BgRT), particularly with systems like RefleXion X1, necessitates robust pre-treatment quality assurance (QA) to ensure patient safety, treatm...
Authors: Wesley E. Bolch, Lotem Buchbinder Shadur, Natalia Estefania Carrasco-Rojas, Chansoo Choi, Robert Joseph Dawson, Shaheen Dewji, John Francis, Emmanual Mate-Kole, Wyatt Smither, Yitian Wang
Affiliation: Georgia Tech, University of Florida, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology
Abstract Preview: Purpose: Develop a software application capable of assessing the radiation contamination of military service members and members of the general public for fast, on-site radiological triage. The softwa...
Authors: Awens Alphonse, Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Tino Romaguera, Hina Saeed, Nishan Shrestha, Somol Sunny
Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida
Abstract Preview: Purpose: Prostate stereotactic body radiation therapy (SBRT) requires precise dose delivery to the target volume and organ-at-risk (OAR) sparing. This study compares MR-Linac (MRL) and CyberKnife (CK)...
Authors: Hsiao-Mei Fu, Shih-Ming Hsu, Chia-Ting Lee, Shih-Hua Liu, Tsung-Yu Yen
Affiliation: National Yang Ming Chiao Tung University, Mackay Memorial Hospital
Abstract Preview: Purpose: The Automatic Lower Dose Objective (ALDO) is a unique function designed to achieve 98% relative coverage across all targets in automated SRS treatment planning (HyperArc planning). This study...
Authors: Dharmin D. Desai, Ellis Lee Johnson, Philip J. Kallenberg, Kapil M. Mishra
Affiliation: Spectrum Medical Physics, University of Kentucky, Varian Advanced Oncology Solutions
Abstract Preview: Purpose: The “Ask For It” (AFI) manual optimization strategy has been shown to generate high quality SRS plans within Eclipse. The purpose of this work is to directly compare manually generated Eclips...
Authors: Deidre Batchelar, Michael Kudla, Stephanie Merkl, Tony Teke
Affiliation: BC Cancer - Kelowna
Abstract Preview: Purpose: Preplanning 3D-printed templates for cervical and vaginal brachytherapy is an iterative process, often taking hours to for an individual patient.
This study demonstrates an end-to-end auto...
Authors: David Chighvinadze, Chieh-Wen Liu, Sugandima Weragoda, Ping Xia
Affiliation: Cleveland Clinic Sandusky, Cleveland Clinic
Abstract Preview: Purpose: To explore the feasibility of using coplanar beams with collimator angle optimization for brain SRS plans with Halcyon system.
Methods: This study used a dataset of 26 patients with 2-3 br...
Authors: Christopher Bartee, Justin Riley DeFrancisco, Marcos Feijoo, Siyong Kim, Tianjun Ma
Affiliation: Blue Physics LLC, Virginia Commonwealth University
Abstract Preview: Purpose: Irradiation with FLASH has been shown to decrease normal tissue toxicity while maintaining similar tumor control. To advance FLASH into the clinic, more preclinical investigations are first n...
Authors: Shinichiro Mori, Isabella Pfeiffer, Chester R. Ramsey, Alexander Usynin
Affiliation: Thompson Proton Center, National Institutes for Quantum Science and Technology, Thompson Cancer Survival Center
Abstract Preview: Purpose: Four-dimensional CT imaging (4DCT) has become a standard tool for managing respiratory motion in radiation therapy. However, many treatment delivery systems and most diagnostic CT scanners la...
Authors: Stella Flampouri, Edgar Gelover, William Andrew LePain, Roelf L. Slopsema, Alexander Stanforth, Mingyao Zhu
Affiliation: Emory Healthcare, Emory University
Abstract Preview: Purpose: Little consideration was given to the change in dose rate (DR) observed when moving to pencil beam scanning (PBS). This study reports on DR in clinical prostate PBS plans. While dose distribu...
Authors: Niels Bassler, Jonathan Bortfeldt, Carlos Granja, Guyue Hu, Margarita Kozak, Julie Lascaud, Kirsten Lauber, Grigory Liubchenko, Jasper Nijkamp, Cristina Oancea, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Brita Singers Sørensen, Matthias Würl
Affiliation: Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital, Advacam
Abstract Preview: Purpose: To apply in-vivo proton radiography (pRad) to aid image registration and treatment plan refinement for a novel precision image-guided small animal proton irradiation platform.
Methods:...
Authors: Jianrong Dai, Jun Dang, Enzhuo Quan, Yong Sang, Jianan Wu
Affiliation: Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, National Cancer Center / National Clinical Research Center for Cancer / Cancer Hospital & Shenzhen Hospital / Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Abstract Preview: Purpose: The current conformity index (CI) formula is distorted for radiotherapy plans with multiple, non-enclosing targets. We redefined the volume of reference isodose (VTV) parameter in the CI form...
Authors: Rex A. Cardan, Carlos E. Cardenas, John B Fiveash, Joel A. Pogue, Richard A. Popple, Farnaz Rahim Li, Rodney J. Sullivan, Natalie N. Viscariello, Christopher Willey
Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham
Abstract Preview: Purpose: vBrain radiosurgery toxicity-rate is estimated via clinically-relevant isodose volume (IDV) thresholds according to HyTEC (e.g., V12Gy≤10cc). HyperArcTM (HA) automated planning allows accurat...
Authors: Steve B. Jiang, Chien-Yi Liao, Dan Nguyen, Daniel Yang, Hengrui Zhao
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose:
Post-operative radiotherapy for prostate cancer requires precise contouring of the clinical target volume (CTV) to account for microscopic disease that is invisible in the image. However, ...
Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang
Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center
Abstract Preview: Purpose: Using mixed fractionation schemes is a common technique in treating CNS lesions. This article describes an innovative plan-and-split approach for more efficient planning on the ZAP-X and thus...
Authors: Chih-Chiang Chang, Chingyun Cheng, Ben Durkee, Minglei Kang, Elissa Khoudary, Yangguang Ma, Xuanqin Mou, YuFei Wang, Tengda Zhang, Wang Zhengda
Affiliation: Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, School of Software Engineering, Xi’an Jiaotong University, School of information and communications engineering, Faculty of electronic and information engineering, Xi’an Jiaotong University, Department of Medical Physics, Columbia University, University of Pennsylvania, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: This study presents a voxel-based analysis method based on deformable image registration to accurately quantify respiratory-induced motion and deformation of both targets and organs at risk (...
Authors: Kristina Bjegovic, Luke Connell, Emil Schueler, Leshan Sun, Lucy Whitmore, Liangzhong Xiang
Affiliation: University of California, Irvine, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: The use of FLASH-RT in the clinic would greatly reduce off-target radiation toxicity in normal tissues. However, due to the hypo-fractionated delivery of prescribed doses at FLASH dose rates,...
Authors: Daisuke Kawahara, Takaaki Matsuura, Yuji Murakami, Ryunosuke Yanagida
Affiliation: Hiroshima High-Precision Radiotherapy Cancer Center, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima
Abstract Preview: Purpose: In recent years, automation in radiation therapy planning using AI has gained significant attention to reduce the workload of treatment planners. Adaptive Radiation Therapy (ART), as a new fo...
Authors: Lili Chen, Xiaoming Chen, Chang Ming Charlie Ma, Joshua Meyer
Affiliation: Fox Chase Cancer Center
Abstract Preview: Purpose: Fast CBCT (HyperSight) acquisition technique together with a surface-guided breath-hold (SGBH) would allow a better image quality for accurate target/organ delineation. It facilitates breath-...
Authors: Albert Admasu, Kayla Alfonso, Maria de la Luz De Ornelas, Nesrin Dogan, Eric Mellon, Yunze Yang
Affiliation: University of Miami, Department of Radiation Oncology, University of Miami, University of Miami Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose: Rotational uncertainties in single-isocenter multi-target (SIMT) stereotactic radiosurgery (SRS) HyperArc treatments can cause additional target displacement, potentially degrading overall pl...
Authors: David L. Barbee, Jose R. Teruel Antolin, Jinyu Xue
Affiliation: NYU Langone Health
Abstract Preview: Purpose: This work introduces a method of regional dose evaluation of normal brain tissue using local target-specific evaluation and compares to global dose evaluation for linac-based single-isocenter...
Authors: Kevin Albuquerque, Ti Bai, Yesenia Gonzalez, Brian A. Hrycushko, Zohaib Iqbal, Paul M. Medin, Shanshan Tang
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Cervical cancer remains one of the most common and significant gynecological (GYN) malignancies globally, often presenting at advanced stages where radiation therapy and high-dose-rate (HDR) ...
Authors: Angela J Da Silva, Andrew Groll, Gopinath Kuduvalli, Thomas Laurence, David W. Meer, Manoj Narayanan, Mingshan Sun, Don Vernekohl, Ray Yang
Affiliation: RefleXion Medical
Abstract Preview: Purpose: To implement post-treatment review of delivered dose fractions on RefleXion X1 accounting for independent detection of transmitted beamlets and transient dose fluctuations of individual pulse...
Authors: Katrinus Keijnemans, Eric S. Paulson, An Tai
Affiliation: Department of Radiotherapy, University Medical Center Utrecht, Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: Time-weighted mid-position images (MidPs), derived from four-dimensional computed tomography (4DCT) via deformable image registration (DIR), are frequently selected for treatment planning due...
Authors: Owen Thomas Dillon, Andrew Kanawati, Tess Reynolds
Affiliation: Westmead Hospital, Image X Institute, Faculty of Medicine and Health, The University of Sydney
Abstract Preview: Purpose: Metal artefacts from implanted hardware and surgical tools remain a limitation for widespread adoption of intraoperative CBCT imaging. Gantry-based non-circular imaging trajectories have emer...
Authors: Lu Jiang, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Conventional radiotherapy treatment planning is guided by a set of generic objectives that are unspecific to patient anatomy. Treatment planning thus heavily relies on the planner’s experi...
Authors: Jae Won Jung, Choonsik Lee, Jason C. Mace, Sergio Morato Rafet
Affiliation: East Carolina University, Carilion Clinic, National Cancer Institute
Abstract Preview: Purpose: Dosimetry for radionuclides used in nuclear medicine can be accurately calculated if sufficient data is available. However, in most cases crucial information cannot or will not be known a pri...