Authors: Weiguo Lu, Hua-Chieh Shao, Guoping Xu, You Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose:
Neural network-based lesion segmentation remains a significant challenge due to the low contrast between lesions and surrounding tissues (high ambiguity) and the variability of lesion shap...
Authors: Cem Altunbas, Farhang Bayat
Affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Taussig Cancer Center, Cleveland Clinic
Abstract Preview: Purpose:
Low dose imaging and scatter rejection hardware in CBCT reduces X-ray fluence incident on the imager, increasing noise, causing photon starvation artifacts in CBCT images. In this work, we...
Authors: Peter Balogh, Wesley E. Bolch, Mir Md Nasim Hossain, Nien-Wen Hu, Walter Murfee, Wyatt Smither, Julia D. Withrow
Affiliation: New Jersey Institute of Technology, University of Florida
Abstract Preview: Purpose: To develop 3D computational, tissue-representative models incorporating physiologically relevant microvascular network patterns for calculating local alpha particle and electron dosimetry eff...
Authors: David J. Gladstone, P. Jack Hoopes, David I Hunter, Brian W Pogue, Jacob Pierce Sunnerberg, Armin Tavakkoli
Affiliation: Thayer School of Engineering, Dartmouth College, University of Wisconsin - Madison, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Geisel School of Medicine, Dartmouth College
Abstract Preview: Purpose: The FLASH effect, characterized by normal tissue sparing under ultra-high dose rate (UHDR) radiation delivery, remains mechanistically unclear. This study investigated the relationship betwee...
Authors: Aditya P. Apte, Joseph O. Deasy, Sharif F. Elguindi, Aditi Iyer, Jue Jiang, Eve Marie LoCastro, Jung Hun Oh, Amita Shukla-Dave, Harini Veeraraghavan
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: We present publicly shareable applications (apps) for AI-based radiotherapy segmentation workflows with pyCERR on Seven Bridges Cancer Genomics Cloud-based platform (CGC-SB)
Methods: Runni...
Authors: Srinivas Cheenu Kappadath, Brian Michael Kelley, Benjamin P. Lopez
Affiliation: UT MD Anderson Cancer Center
Abstract Preview: Purpose:
Imaging systems are subject to errors from finite spatial resolution and voxel size. This work demonstrates their effect on dose algorithm {Monte Carlo (MC), dose-volume kernel (DVK), and ...
Authors: Joshua Misa, Damodar Pokhrel, William St. Clair
Affiliation: University of Kentucky, Department of Radiation Medicine
Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumorâs center, surrounded by smaller diameter spheres. W...
Authors: Fatemeh Akbari, Artemis Dalby, Nelson A. Miksys, Prarthana Pasricha, Rowan M. Thomson
Affiliation: Ackerman Cancer Center, Carleton University
Abstract Preview: Purpose: To investigate dose evaluations for GammaTile brachytherapy, a novel treatment for brain malignancies. The analysis focuses on the impact of tissue heterogeneities, including the presence of ...
Authors: Dennis A. Cheek, Wei Luo, Cameron Thayer-Freeman, Brien Timothy Washington
Affiliation: UT Southwestern Medical Center, University of Kentucky, Department of Radiation Medicine, University of Kentucky
Abstract Preview: Purpose: To investigate the effect of variation in the α/ÎČ of cervical cancer on clinical outcome for cervix cancer patients treated with radiation therapy.
Methods: A distribution of experimentall...
Authors: Jing Cai, Zhi Chen, Hong Ge, Yu-Hua Huang, Bing Li, Zihan Li, Ge Ren
Affiliation: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital
Abstract Preview: Purpose: Algorithms based on subregional respiratory dynamics (SRD) capture spatiotemporal heterogeneity in the ventilation process, though rely on empirical modelings to map surrogate ventilation. Gi...
Authors: Jadon Buller, Zhuoran Jiang, Yankun Lang, Lei Ren, Leshan Sun, Liangzhong Xiang, Yifei Xu
Affiliation: University of Maryland School of Medicine, University of California, Irvine, University of California, Stanford University
Abstract Preview: Purpose: Electroacoustic tomography (EAT) and Protoacoustic (PA) imaging are novel modalities for treatment verification of electroporation and proton therapy. However, the limited acquisition angle i...
Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Alex T. Price, Sagar Regmi, Atefeh Rezaei, Runyon C. Woods
Affiliation: University Hospitals Seidman Cancer Center
Abstract Preview: Purpose: To investigate the feasibility and accuracy of using a Hounsfield Unit(HU) calibrated cone-beam computed tomography(CBCT) for direct dose calculation in thoracic treatment settings. In combin...
Authors: Caiden Atienza, Pim T. S. Borman, Martin F. Fast, Daniel E. Hyer, Bas W. Raaymakers, Jeffrey E. Snyder, Prescilla Uijtewaal, Peter Woodhead
Affiliation: Department of Radiotherapy, University Medical Center Utrecht, Yale New Haven Health, University of Iowa
Abstract Preview: Purpose:
On conventional C-arm linacs, VMAT is the preferred delivery modality due to its superior efficiency and highly conformal dose distributions. MR-linacs offer superior soft-tissue imaging t...
Authors: Beverly Allen, Jay C. Buckey, David J. Gladstone, P. Jack Hoopes, David I Hunter, Armin Tavakkoli
Affiliation: Thayer School of Engineering, Dartmouth College, Geisel School of Medicine, Dartmouth College, Geisel School of Medicine, Thayer School of Engineering
Abstract Preview: Purpose: Hyperbaric oxygen (HBO) therapy immediately prior to radiation therapy has been proposed as treatment to enhance radiosensitivity of hypoxic tumors. A murine glioblastoma model was utilized t...
Authors: Xiangli Cui, Wei Han, Jie Li, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences
Abstract Preview: Purpose: To investigate the influence of tissue heterogeneity on proton beam linear energy transfer (LET) and relative biological effectiveness (RBE) using nine RBE models. This study quantifies the i...
Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Christian Erik Petersen, Alex T. Price, Atefeh Rezaei, Runyon C. Woods
Affiliation: University Hospitals Seidman Cancer Center
Abstract Preview: Purpose: CBCT is subject to more artifacts due to increased photon scatter, especially in areas of increased tissue heterogeneities compared to fan-beam CTs (FBCTs). Improved imaging panels combined w...
Authors: NadÚge Anizan, Jean-Noël Badel, Thomas Baudier, David Broggio, Désirée Deandreis, Ludovic Ferrer, Didier Franck, Camilo Garcia, Jean Gasteuil, Anne-Laure Giraudet, Olivier Humbert, Laetitia Imbert, Malick Koulibaly, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard, Caroline Rousseau, Guido Rovera, David Sarrut, Paul Schwartz, Nicolas Varmenot
Affiliation: Institut de CancĂ©rologie de lâOuest, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de Physique MĂ©dicale, Institut BergoniĂ©, Service de Physique MĂ©dicale, CHRU de Nancy Brabois, Service de MĂ©decine NuclĂ©aire, Centre de lutte contre le cancer LĂ©on BĂ©rard, UniversitĂ© de Lyon, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, UniversitĂ© Nice CĂŽte dâAzur, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de MĂ©decine NuclĂ©aire, Institut de CancĂ©rologie de lâOuest, Service de Physique MĂ©dicale, Service de MĂ©decine NuclĂ©aire, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSAâLyon, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSAâLyon; Centre de lutte contre le cancer LĂ©on BĂ©rard, Institut BergoniĂ©, Service de MĂ©decine NuclĂ©aire
Abstract Preview: Purpose: The main objective of the Lu-PSMA-Dose study, sponsored by ASNR, is to estimate retrospectively the individual absorbed dose delivered to patients treated with 177Lu-PSMA for metastatic castr...
Authors: Dirk A Bartkoski, Leonard Che Fru, Benjamin Abraham Insley, Michael Kleckner, Dongyeon Lee, Reza Reiazi, Mohammad Reza Salehpour, Aviad Schori, Ramesh C. Tailor
Affiliation: Empyrean Medical Systems, The University of Texas MD Anderson Cancer Center, Convergent-RnR, The University of Texas, MD Anderson, Houston TX
Abstract Preview: Purpose: A Geant4-based model was created for a G4BraggReflection process to simulate radiation transport within a novel radiotherapy system developed by Convergent Radiotherapy and Radiosurgery (CRnR...
Authors: Michael M Folkerts, Miriam Krieger, Pierre Lansonneur, Gerard Paquet, Petar Penchev, Christoph Schuy, Yuri Simeonov, Uli Weber, Klemens Zink
Affiliation: GSI Helmholtzzentrum fuer Schwerionenforschung, Institute of Medical Physics and Radiation Protection (IMPS), University of Applied Sciences, Varian Medical Systems
Abstract Preview: Purpose:
Ultra-high dose-rate proton irradiation may spare the healthy tissue (FLASH-effect). The 3D-range-modulator (3D-RM) method reduces the treatment time compared to conventional IMPT and can ...
Authors: Michael B. Altman, Marlene Campos Guerrero, Stephanie Markovina, Aaron Silvus
Affiliation: Washington University School of Medicine
Abstract Preview: Purpose: Currently, fluid injections or needle biopsies in small animals are conducted with limited optical guidance introducing an inherent risk of infecting or injuring the animal and limits precisi...
Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng
Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...
Authors: Aditya P. Apte, Joseph O. Deasy, Sharif Elguindi, Aditi Iyer, Jue Jiang, Eve Marie LoCastro, Jung Hun Oh, Amita Shukla-Dave, Harini Veeraraghavan
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: We present port of popular Computational Environment for Radiological Research software platform to Python programming language to cater to cloud-based analyses.
Methods: The components of...
Authors: Steve B. Jiang, Austen Matthew Maniscalco, Dan Nguyen, Chenyang Shen, Jiacheng Xie, Shunyu Yan, Ying Zhang, You Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas
Abstract Preview: Purpose: Although treatment planning systems (TPSs) can handle dose calculation and plan optimization automatically, planning for radiotherapy still requires extensive efforts and expertise from a mul...
Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang
Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill
Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...
Authors: Garrett Russell Hamilton, Joshua Misa, Damodar Pokhrel, William St. Clair
Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine
Abstract Preview: Purpose: Recurrent brain metastasis is very common, and patients who previously received whole-brain radiotherapy (WBRT) may receive an additional course(s) of stereotactic radiosurgery (SRS) to selec...
Authors: David L. Barbee, Jose R. Teruel Antolin, Jinyu Xue
Affiliation: NYU Langone Health
Abstract Preview: Purpose: This work introduces a method of regional dose evaluation of normal brain tissue using local target-specific evaluation and compares to global dose evaluation for linac-based single-isocenter...
Authors: Ana Maria Barragan Montero, John A. Lee, Eliot Peeters, Romain Schyns, Edmond S. Sterpin, Sophie Wuyckens
Affiliation: UCLouvain, Universite Catholique de Louvain
Abstract Preview: Purpose:
Although the likelihood of a point being tumorous decreases with distance from the GTV, CTVs are still defined as binary masks. Recently, the concept of clinical target distribution (CTD),...