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Results for "mda 231": 41 found

A Causal Machine Learning Analysis of Dosimetric and Clinical Predictors of Osteoradionecrosis in Head and Neck Cancer Radiotherapy

Authors: Jingyuan Chen, Sheng Li, Tianming Liu, Wei Liu, Zhengliang Liu, Zhong Liu, Daniel Ma, Samir H. Patel, Guangya Wang, Yunze Yang

Affiliation: University of Miami, Mayo Clinic, School of Data Science, University of Virginia, School of Computing, University of Georgia, Department of Radiation Oncology, Mayo Clinic, Institute of Western China Economic Research, Southwestern University of Finance and Economics

Abstract Preview: Purpose:
Traditional patient outcome analyses relied heavily on conventional statistical models that primarily elucidate correlation rather than causal relationships. In this study, we aim to ident...

A Comparison of the Impact to Mean Doses to Organs at Risk of Small Versus Large Spot Sizes in Pelvic Proton Therapy

Authors: Jamie s Baker, Sam Beddar, Mahsa Dehghanpour, Ariel MT Hoang, Emma Holliday, Rachael M. Martin Paulpeter, Joshua S. Niedzielski, Luis Augusto Perles, Josie S Ruzek, Gabriel O. Sawakuchi

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, niversity of Texas MD Anderson Cancer Center School of Health Professions, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, University of Texas MD Anderson Cancer Center School of Health Professions

Abstract Preview: Purpose: This study aims to evaluate the dosimetric impact on organs at risk (OAR) of small versus large spot sizes when treating pelvic cancer patients with pencil beam scanning (PBS) proton therapy....

Assessment of Alpha-Fetoprotein As a Prognostic Factor of Overall Survival for HCC Patients Undergoing 90Y-Glass Trans-Arterial Radioembolization

Authors: Srinivas Cheenu Kappadath, James Long, Armeen Mahvash, Anna Marks, Ajalaya Teyateeti

Affiliation: Mahidol University, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center

Abstract Preview: Purpose:
Alpha-fetoprotein (AFP) has been implicated as prognostic factor of overall survival (OS) for hepatocellular carcinoma (HCC). We present a statistical approach to determine optimal AFP-cut...

Assessment of Plan Quality Metrics for Iroc Houston SRS Phantom Performance Evaluation

Authors: Derek Matthew Garcia, Mallory Glenn, Stephen F. Kry, Ruitao Lin, Dennis S. Mackin, Tucker J. Netherton

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, University of Texas’ MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Houston

Abstract Preview: Purpose: This study aims to investigate the feasibility of implementing clinically relevant quality metrics for evaluating IROC SRS phantom plans, including conformity index (CI) and homogeneity index...

Automated Full-Body Tumor Segmentation from PET/CT Images

Authors: Austin Castelo, Xinru Chen, Caroline Chung, Laurence Edward Court, Jaganathan A Parameshwaran, Zhan Xu, Jinzhong Yang, Yao Zhao

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose:
To develop a deep learning-based segmentation model to automatically delineate tumors from full-body PET/CT images.
Methods:
PET/CT image pairs of 91 patients were collected for this...

BEST IN PHYSICS RADIOPHARMACEUTICALS, THERANOSTICS AND NUCLEAR MEDICINE: The Development and Validation of an in-Vitro Alpha Irradiation Platform with Versatile Radiation Control

Authors: Md Mainul Abrar, Harsh Arya, Yujie Chi, Yijing Liu, Joshua Rajan, Pan Zui

Affiliation: University of Texas at Arlington, The University of Texas at Arlington, Department of Physics, University of Texas at Arlington

Abstract Preview: Purpose: Understanding the biological effects of alpha radiation at varying dose rates and energies is essential for advancing therapeutic strategies. This study demonstrates the capabilities of an in...

BEST IN PHYSICS THERAPY: Immunomodulatory Effects of Selective PARP1 Inhibition in Combination with Photon and Alpha Particle Therapy in Immunologically Cold Breast Cancer

Authors: Scott James Bright, Vered Domankevich-Bachar, Mandira Manandhar, Poliana Marinello, Yogesh Rai, Marco Freitas Reis, Alexandre Rubinstein, Gabriel O. Sawakuchi, Ronen Segal, Walison Augusto Silva Brito, Mark Wasley, Amy Wu

Affiliation: MD Anderson Cancer Center, Alpha Tau Medical Ltd, Alpha Tau Medical LTD, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Immunologically cold breast cancers are aggressive and difficult to treat due to their lack of immune cell infiltration. The combination of high-LET radiation with DNA repair inhibitors offer...

Brain Structural Covariance Networks in Nicotine-Dependent Users: A Graph Analysis

Authors: Humberto Monsivais, Brian A. Taylor, Francesco Versace

Affiliation: Purdue University, Department of Behavioral Science, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: To identify possible signatures of altered brain morphometry in nicotine-dependency via a structural covariance network approach.

Methods: Fifty-one healthy controls (HC:27M, mean age=...

Can We Use Smaller Margin for the Planned Target Volume with Adaptive Radiotherapy?

Authors: Mahmoud H Abdelgawad, Shahabeddin mostafanazhad Aslmarand, Lili Chen, Xiaoming Chen, Ahmed A. Eldib, Teh Lin, Chang Ming Charlie Ma, Robert A. Price

Affiliation: Physics department, Faculty of science, Al-Azhar University, Fox Chase Cancer Center

Abstract Preview: Purpose: Many modern radiotherapy clinics are moving to online adaptive radiotherapy. A recent upgrade of the CBCT-based adaptive radiotherapy system introduced ultra-high-speed image acquisition. Thi...

Clinical I-131 Dosimetry: Audit, Review, and Evaluation

Authors: Colin Adam Doyle, Celeste Winters

Affiliation: Department of Diagnostic Radiology, Oregon Health & Science University, School of Medicine, Oregon Health & Science University

Abstract Preview: Purpose: To audit our radioactive iodine (I-131) dosimetry protocol, review dosimetry methods used at other facilities, investigate the clinical impact of I-131 dosimetry at our facility, and test the...

Clinically Tenable Lung Dose Estimates in Y-90 Radioembolization from Truncated Maa-SPECT/CT with Unknown Lung Mass

Authors: Dan Giardina, John Karageorgiou, Chris Malone, Naganathan Mani, Allan Thomas

Affiliation: Washington University School of Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine

Abstract Preview: Purpose: Relative to planar imaging, MAA-SPECT/CT offers more reliable lung shunt fraction (LSF) and lung mean dose (LMD) estimates in 90Y radioembolization. But lung truncation in SPECT/CT can limit ...

Deep Learning Based Automatic Cerebrovascular Segmentation in Multi-Center TOF-MRA Datasets

Authors: Gayoung Kim, Junghoon Lee

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University

Abstract Preview: Purpose: 3D time-of-flight magnetic resonance angiography (TOF-MRA) is widely used for visualizing cerebrovascular structures. Accurate segmentation of cerebrovascular structures is critical for relia...

Development and Validation of a Principal Component Analysis Statistical Shape Pediatric/Adolescent Breast Model for Pre-CT Era Breast Dose Reconstruction in Late Effect Studies of Female Childhood Cancer Survivors

Authors: Gregory T. Armstrong, James E. Bates, Kristy K. Brock, Laurence Edward Court, Matt Ehrhardt, Danielle Friedman, Aashish C. Gupta, Donald Hancock, Rebecca M. Howell, Cindy Im, Tera S Jones, Choonsik Lee, Wendy Leisenring, Taylor Meyers, Lindsay Morton, Chaya Moskowitz, Joe Neglia, Vikki Nolan, Caleb O'Connor, Kevin C. Oeffinger, Constance A. Owens, Arnold C. Paulino, Chelsea C. Pinnix, Sander Roberti, Cecile Ronckers, Susan A. Smith, Kumar Srivastava, Lucie Turcotte

Affiliation: Department of Medicine, Duke University School of Medicine, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, The University of Texas MD Anderson Cancer Center, Department of Oncology, St. Jude Children’s Research Hospital, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, Division of Childhood Cancer Epidemiology, University Medicine at Johannes Gutenberg University Mainz, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Pediatrics, University of Minnesota, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Biostatistics, St. Jude Children’s Research Hospital, Clinical Research Division, Fred Hutchinson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences

Abstract Preview: Purpose: To (1) develop and validate a novel anatomically realistic pediatric/adolescent population-based breast model, (2) incorporate model into an age-scalable female reference phantom, and (3) dem...

Development of an MRI Guided Precision Small Animal Radiotherapy System

Authors: Yaowen Cao, Yunwen Huang, Yidong Yang, Xiaogang Yuan, Ning Zhao, Cheng Zheng

Affiliation: Department of Life Sciences and Medicine, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China, University of Science and Technology of China

Abstract Preview: Purpose: MRI has better soft tissue contrast than cone beam CT which is commonly used in image guided radiotherapy. This study aims to develop a low-field MRI system for precision small animal radiati...

Do We Need Pediatric-Specific Models for Radiotherapy Auto-Contouring? a Comparative Study of Pediatric and Adult-Trained Tools

Authors: Gregory T. Armstrong, James E. Bates, Christine V. Chung, Lei Dong, Ralph Ermoian, Jie Fu, Christine Hill-Kayser, Rebecca M. Howell, Meena S. Khan, Sharareh Koufigar, John T. Lucas, Thomas E. Merchant, Taylor Meyers, Tucker J. Netherton, Constance A. Owens, Arnold C. Paulino, Sogand Sadeghi

Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, St. Jude Children's Research Hospital, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Department of Radiation Oncology, St. Jude Children’s Research Hospital, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, University of Washington/ Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences

Abstract Preview: Purpose: Clinical workflows often rely on auto-segmentation tools trained on adult data, which may exhibit suboptimal performance in pediatric imaging due to inherent anatomical variations and smaller...

Dose Mapping of Radioactive Gold Nanoparticles Using Three-Dimensional Dosimetry

Authors: Ana Laura Burin, Maysa Müller Ferreira Gesserame, David Alexander Urbina Leal, Ilca Marli Moitinho Amaral Medeiros, Silas Leonel Pereira Miranda, Thuany Corrêa Nogueira, Maria da Penha Alburquerque Potiens, Pedro Henrique Ricardo, Maria Eduarda Zaganin Rigo, Orlando Rodrigues, Priscila Santos Rodrigues, Wilmmer Alexander Arcos Rosero, Maria Elisa Chuery Martins Rostelato, Sabrina Spigaroli Sgrignoli, Ana Catarina Koka de Souza Silva, Cristhian Ferreira Talacimon, Paulo Victor dos Santos Tavares, Lara El Hajj Teodoro, Carlos Alberto Zeituni, José Neres de Almeida

Affiliation: IPEN - USP

Abstract Preview: Purpose: Perform three-dimensional dosimetry of radioactive gold nanoparticles (¹⁹⁸AuNPs) using Fricke xylenol gel (FXG), aiming to determine the dose distribution and evaluate the method's effectiven...

Dosimetry Commissioning of a Commercial Cabinet X-Ray Irradiator for Small Animal Irradiation

Authors: Sang Hyun Cho, Amrit Kaphle, Sunil Krishnan, Neerajan Nepal

Affiliation: The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center

Abstract Preview: Purpose: To determine the basic dosimetry parameters and characteristics of a commercial cabinet x-ray unit for small animal irradiation as well as the specific dosimetry parameters for concurrent irr...

Early Imaging Identification of Osteoradionecrosis and Classification Using the Novel Clinrad System

Authors: Serageldin Attia, Zayne Belal, Cem Dede, Clifton David Fuller, Andrew Hope, Laia Humbert Vidan, Kate Hutcheson, Zaphanlene Kaffey, Stephen Y. Lai, Abdallah Mohamed, Amy Moreno, Jillian Rigert, Erin Watson

Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Princess Margaret Cancer Centre, University Health Network, 610 University Ave., The University of Texas MD Anderson Cancer Center, UT MD Anderson, Princess Margaret Cancer Centre, UT MD Anderson Cancer Center, Hospital of the University of Pennsylvania, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Head and Neck Surgery, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology

Abstract Preview: Purpose: Osteoradionecrosis (ORN) of the jaw is a debilitating radiation-induced toxicity lacking standardized classification criteria or treatment guidelines. Early identification of tissue injury co...

Establishing Energy Thresholds for Targeted Cherenkov Light Photoactivation

Authors: David Alcorta, Lindsay Bolino, Olivia Canter, Seifallah Emam, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, David Loiselle, Mark Oldham, Victoria J. P. Radosova

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke Univerity, Department of Radiation Oncology, Duke University Medical Center

Abstract Preview: Purpose: To simulate how Cherenkov light (CL) produced during radiation therapy can activate targeted photodynamic molecules. To experimentally determine dose and concentration thresholds for biologic...

Evaluating the Performance and Limitations of an Automated Treatment Planning Tool for Intact Breast Radiotherapy across Diverse Patient Populations

Authors: Shatha Al Afifi, Hana Baroudi, Leonard Che Fru, Laurence Edward Court, Suzanne B. Evans, Kent A. Gifford, Adam D. Melancon, Melissa P. Mitchell, Issa Mohamad, Patricia Murina, Manickam Muruganandham, Tucker J. Netherton, Callistus M. Nguyen, Joshua S. Niedzielski, Deborah L. Schofield, Simona Shaitelman, Willie Shaw, Sanjay S. Shete, Adam Shulman, Brendon Smith, Sheeba Thengumpallil, Carlos Daniel Venencia, Conny Vrieling

Affiliation: University of Cape Town, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, University of the Free State, UT MD Anderson Cancer Center, King Hussein Cancer Center, Instituto Zunino - Fundacion Marie Curie, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Dra., Hirslanden Clinique des Grangettes, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Therapeutic Radiology, Yale University School of Medicine, Yale University, The University of Texas, MD Anderson, Houston TX

Abstract Preview: Purpose:
Automated contouring and planning tools are usually trained on single-institution datasets, seldom tested across diverse patient populations. This introduces a risk of population bias, res...

Evaluating the Theranostic Potential of a Novel Shark Derived Anti-MET Vnar Antibody in NSCLC

Authors: Andrew M Baschnagel, Jonathan W. Engle, Jessica E. Griffin, Gihan Gunaratne, Reinier Hernandez, Randall J Kimple, Aaron M. LeBeau, Natalie Y. Luo, Rachel Minne, Caroline M. Mork, Kwangok P Nickel, Jayden West, Madalynn R. Wopat

Affiliation: University of Wisconsin, University of Wisconsin, Department of Pathology and Laboratory Medicine, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, University of Wisconsin - Department of Human Oncology, UW Madison, University of Wisconsin, Department of Medical Physics

Abstract Preview: Purpose: The Mesenchymal-Epithelial Transition gene (MET), a targetable cell surface receptor responsible for stimulating cell growth and proliferation, is altered in approximately 10% of non-small ce...

Evaluation of Synaptive MRI Geometric Distortion with Sun Nuclear MR Distortion and Image Fusion Head Phantom

Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Jing Feng, Wenzheng Feng, Joseph Hanley, Jeff Stainsby, Tingyu Wang

Affiliation: Synaptive Medical, Hackensack Meridian Health, Jersey Shore University Medical Center

Abstract Preview: Purpose:
The Synaptive MRI is a 0.5T superconducting head only system (first US install 2023). This is the first study that evaluates the geometric accuracy using a Sun Nuclear MR Distortion and Im...

Feasibility of Producing GRID Therapy Dosimetry Using a Compact Linac Treatment Head with Pencil Beam Scanning

Authors: Yiran Liu, Zhengzheng Liu, Fang-Fang Yin

Affiliation: Duke Kunshan Univeristy, Huazhong University of Science and Technology, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: To investigate the feasibility of producing high dose rate GRID therapy using a compact linear accelerator (LINAC) treatment head with scanning beam and stationary grid collimator.
Methods...

Free-Breathing VMAT and IMRT Versus Deep Inspiration Breath- Hold 3D-CRT Techniques for Left-Breast Cancer: A Practical Solution for Developing Countries

Authors: Md. Yousuf Ali, Parvin Akhter Banu, Ehteshamul Hoque, Qazi Mushtaq Hussain, Md Jobairul Islam, Md. Abdul Mannan, Sadia Afrin Sarah, Mostafa Aziz Sumon, Ahammad Al Mamun Sweet, AFM Kamal Uddin

Affiliation: Labaid Cancer Hospital & Superspeciality Centre

Abstract Preview: Purpose: Radiotherapy for left-sided breast cancer can induce cardiac injury. Deep Inspiration Breath Hold (DIBH) is a technique that minimizes cardiac exposure during treatment. This study compares d...

GPU-Accelerated Beamlet and Full Dose Calculations for Efficient Radiation Therapy Planning

Authors: Girish Bal, Jan Kralj, Ayan Mitra, PhD, Ling Shao, Matjaz Subic, Yevgen Voronenko

Affiliation: RefleXion Medical, Cosylab

Abstract Preview: Purpose: This work enhances the efficiency of radiation therapy treatment planning by optimizing the beamlet dose matrix and full patient dose computations using GPU acceleration. The Collapsed-Cone C...

Geographic Disparities in Medical Physics Training and Employment: Implications for Rural Workforce Recruitment

Authors: Seth Amofa, Erli Chen, Samuel A. Einstein, Ekinadoese Imudia Frias, Nupur Karmaker, Yinus Kawthara, Dulguun Myagmarsuren, Travis C. Salzillo, Joseph Weygand, Afua A. Yorke

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, University of Washington, Federal University Oye-Ekiti, Cheshire Medical Center, Dartmouth College, Penn State College of Medicine, Dept. of Medical Physics and Biomedical Engineering, Gono Bishwabidyalay, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Virginia Tech Carilion School of Medicine

Abstract Preview: Purpose: Recent developments in the medical physics job market have made it increasingly difficult for radiotherapy centers, particularly in rural areas, to recruit qualified therapeutic medical physi...

JACK KROHMER EARLY-CAREER INVESTIGATOR COMPETITION WINNER: Direct Measurement of an Early Change in Tumor Oxygenation in Response to Radiation with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE-EPRI)

Authors: Jorge De La Cerda, Andrew Joseph Fanning, Tianzhe Li, Xiaofei Liang, Grace Murley, Mark Pagel, William Schuler, Renee Tran, Shuo Wang, Su-Min Zhou

Affiliation: University of Wisconsin Madison, University of Nebraska Medical Center, University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Electron paramagnetic resonance imaging (EPRI) can be used to image partial pressure of oxygen (pO2) in tumor models. The goal of this study is to develop an Oxygen Enhanced EPRI protocol to ...

Lung Mass Variability in Clinical Chest CT Imaging with Automatic Contouring Tool

Authors: Yasaman Anbari, Srinivas Cheenu Kappadath, Benjamin P. Lopez

Affiliation: University of Houston, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To improve lung dosimetry for 90Y-radioembolization planning, CT-based techniques have been proposed for patient-specific lung mass estimation instead of assuming nominal 1 kg lung masses. He...

Multi-Institutional Analysis of CT Dose Index Variability and Radiomics Features

Authors: Caroline Chung, Michael Knopp, Stephen F. Kry, Hunter S. Mehrens, John Rong

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, University of Cincinnati

Abstract Preview: Purpose: To evaluate the variability of CT dose index (CTDIvol) and radiomics features across a large cohort of radiotherapy simulation CT scans from multiple institutions.
Methods: Three IROC phan...

One Year Experience of Biology-Guided Radiotherapy (BgRT) on PET-Linac in an Academic Center

Authors: Shahed Badiyan, Girish Bal, Thomas I. Banks, Bin Cai, Tu Dan, Aurelie Garant, Andrew R. Godley, Steve Jiang, Orhan Oz, Arnold Pompos, Rameshwar Prasad, Chenyang Shen, David Sher, Robert Timmerman, Kenneth Westover

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical

Abstract Preview: Purpose: Biology-guided radiotherapy (BgRT) is a novel FDA-cleared technology for treating lung and bone tumors based on 18F-FDG PET uptake. This study summarizes the first-year experience treating 29...

Optimizing the Collimator Angles in Radiation Isocenter Localization Using Winston-Lutz Tests

Authors: Weiliang Du

Affiliation: The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Winston-Lutz (WL) tests are often used to localize the radiation isocenter of a linac. The selection of gantry and collimator angles can affect the accuracy of the resulting isocenter. The ef...

Patient-Specific Imaging Modality Agnostic Virtual Digital Twins Modeling Temporally Varying Digestive Motion

Authors: James M. Balter, Lando S. Bosma, Jorge Tapias Gomez, Nishant Nadkarni, Mert R Sanbuncu, William Paul Segars, Ergys D. Subashi, Neelam Tyagi, Harini Veeraraghavan

Affiliation: University of Michigan, The University of Texas MD Anderson Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Cornell University, University Medical Center Utrecht, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Develop patient-specific virtual digital twin (VDT) cohorts modeling physically realistic spatio-temporal gastrointestinal (GI) organs (stomach and duodenum) digestive motion.
Methods: Pat...

Performance Evaluation of Patient Demographics Model-Based Liver Volumetry

Authors: Yasaman Anbari, Srinivas Cheenu Kappadath, Benjamin P. Lopez, Armeen Mahvash, Ali Yousefi

Affiliation: University of Houston, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Patient-demographics-model-based liver volumetry is well-established for determining the future liver remnant following hepatectomy. We used gold-standard CT liver segmentation to validate th...

Preclinical Assessment of Novel Targeted Chelate-Based Radiopharmaceuticals for Aggressive Cancer Detection

Authors: David Alcorta, Joseph Farina, Timothy Haystead, Yiping He, Philip Hughes, David Loiselle, Marybeth Nedrud, Victoria J. P. Radosova, Jianpeng Yu

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke University School of Medicine, Duke Cancer Institute

Abstract Preview: Purpose: Targeted radiopharmaceuticals have become of widespread interest in the scientific community given their ability to detect and treat metastatic disease. We aim to validate the use of novel ch...

Role of Medical Physicists in Radiopharmaceutical Regulations: An International Perspective

Authors: Caridad Borras

Affiliation: Radiological Physics and Health Services

Abstract Preview: Purpose: The production, use, and disposal of radiopharmaceuticals must comply with regulations for drugs (medicines) and radiation. The relevant roles and requirements for medical physicists to be in...

Secondary Neutron Dosimetry of Cieds Exposed to Neutron-Producing Photon Radiation Therapy

Authors: Angela Gearhardt, Stephen F. Kry, Christopher Ryan Peeler, Julianne M. Pollard-Larkin

Affiliation: The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: A growing number of radiation therapy (RT) patients have cardiovascular implantable electronic devices (CIEDs). Patients with CIEDs must be carefully managed because the devices are susceptib...

Teach What You See: Incorporating Theranostics Curriculum into Medical Physics Resident Education

Authors: Isaac J. Bailey, Lindsay S. DeWeese, Anna M. Mench, Celeste Winters

Affiliation: Oregon Health & Science University, Department of Diagnostic Radiology, Oregon Health & Science University

Abstract Preview: Purpose: The emergence and recent FDA approval of several new radiopharmaceutical therapies have increased demand for physicists to provide specialized support. However, these topics are not yet inclu...

Validation and Benchmarking of Mirdct Software for Organ Dose Estimation in Routine CT Protocols

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Gunjan Kayal, Adam Leon Kesner, Harry Marquis, Juan Camilo Ocampo Ramos, Stefan Wehmeier

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: Accurate organ dose estimation in computed tomography (CT) has gained attention due to the increasing global utilization of CT imaging. MIRDct, a specialized CT dosimetry software, has recent...

Validation of a Simulation Tool and in-Silico Assessment of Low Contrast Detectability for Super-Resolution Deep Learning Reconstruction

Authors: Naruomi Akino, Kirsten Lee Boedeker, Ilmar Hein, Akira Nishikori, Daniel W Shin

Affiliation: Canon Medical Systems Corporation, Canon Medical Research USA

Abstract Preview: Purpose: To validate a simulation tool using physics-based image quality metrics in both phantom and patient data, and to assess the low contrast detectability (LCD) of Super Resolution-Deep Learning ...

Weekly Changes in Ventilation Response for Photon and Proton Patients during Radiotherapy

Authors: Kristy K. Brock, Austin Castelo, Yulun He, Zhongxing Liao, Rebecca Lim, Radhe Mohan, Caleb O'Connor, Tien T Tang, Uwe Titt

Affiliation: University of Washington, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Conformal dose distributions in proton radiotherapy promise to reduce normal tissue toxicity such as radiation-induced pneumonitis, but this has not been fully realized in clinical trials. To...

What Do We Do with Our Old Pinnacle Data?

Authors: Caiden Atienza, Daniel E. Hyer, Samuel D. Rusu, Blake R. Smith, Joel J. St-Aubin

Affiliation: Iowa Health Care, University of Iowa

Abstract Preview: Purpose: Pinnacle3 TPS (Philips Radiation Oncology Systems, Fitchburg, WI, USA) support is set to end by December 31, 2026. This work presents a validated method to archive Pinnacle data, which may be...