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Results for "multi organ": 48 found

A Dual Energy CT-Guided Intelligent Radiation Therapy Platform

Authors: Jiayi Chen, Manju Liu, Ning Wen, Haoran Zhang, Yibin Zhang

Affiliation: Department of Radiation Oncology, Ruijin Hospital, Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Duke Kunshan University, Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Abstract Preview: Purpose: This study introduces a novel Dual Energy CT (DECT)-Guided Intelligent Radiation Therapy (DEIT) platform designed to streamline and optimize the radiotherapy process. The DEIT system combines...

A Multi-Criteria Optimization Method Based on Reinforcement Learning and Adaptive Boosting in Radiation Therapy

Authors: Liqin HU, Tao He, Jing JIA, Pengcheng LONG, Wei Meng, Yang Yuan

Affiliation: SuperAccuracy Science & Technology Co. Ltd.

Abstract Preview: Purpose: A multi-criteria optimization method based on reinforcement learning and adaptive boosting(RLAB MCO) has been developed to enhance radiotherapy plan quality by offering reasonable and effecti...

A Practical Experimental Software Validation Method for Voxel-Based Personalised Dosimetry in Radiopharmaceutical Therapy

Authors: Thomas Gee, Sofia Michopoulou, Amit Nautiyal

Affiliation: University Hospital Southampton

Abstract Preview: Purpose: Dosimetry software that is accessible to departments offers new opportunities to improve patient-specific dosimetry. Prior to clinical decision-making, it is essential to validate dosimetry s...

AI Auto-Contouring for CT-Based High-Dose-Rate Interstitial Brachytherapy of Cervical Cancer: Implications for Organ-at-Risk (OAR) Contouring and Dosimetric Analysis

Authors: Indrin J. Chetty, Jing Cui, Mitchell Kamrava, Tiffany M. Phillips, Jennifer M. Steers, Brad Stiehl

Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center

Abstract Preview: Purpose: Auto-contouring for HDR interstitial brachytherapy can be confounded by large deformation in anatomy and image quality. Here we evaluated the performance of an AI-based auto-contouring softwa...

AI-Based SBRT Dose Prediction Directly from Diagnostic PET/CT: Applications for Multi-Disciplinary Lung Cancer Care

Authors: Pradeep Bhetwal, Wookjin Choi, Adam Dicker, Rupesh Ghimire, Yingcui Jia, Lauren Nkwonta, Yevgeniy Vinogradskiy, Wentao Wang, Maria Werner-Wasik

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: Multi-disciplinary clinics are becoming standard of care for patients with lung cancer treated with SBRT. To improve clinical decision support in a multi-disciplinary clinic, it would be bene...

Abdomen CT Multi-Organ Segmentation Using Multi-Granularity Feature Extraction

Authors: Zilei Fu, Yi Guo, Wanli Huo, Hongdong Liu, Laishui Lyu, Zhao Peng, Yaping Qi, Senting Wang

Affiliation: Department of Radiotherapy, cancer center, The First Affiliated Hospital of Fujian Medical University, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University, Division of lonizing Radiation Metrology, National Institute of Metrology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, China Jiliang University, Department of Oncology, Xiangya Hospital, Central South University

Abstract Preview: Purpose: Medical image boundaries are commonly characterized by smooth gray-level transitions, resulting in pixel-level segmentation errors near these blurred boundaries. To address this, we developed...

An Automated Tool for the Categorization of a Clinical Database By Anatomic Region for Big Data Applications

Authors: Yasin Abdulkadir, Justin Hink, James M. Lamb, Jack Neylon

Affiliation: Department of Radiation Oncology, University of California, Los Angeles

Abstract Preview: Purpose: Curation remains a significant barrier to the use of ‘big data’ radiotherapy planning databases of 100,000 patients or more. Anatomic site of treatment is an important stratification for almo...

Automated Full-Body Tumor Segmentation from PET/CT Images

Authors: Austin Castelo, Xinru Chen, Caroline Chung, Laurence Edward Court, Jaganathan A Parameshwaran, Zhan Xu, Jinzhong Yang, Yao Zhao

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose:
To develop a deep learning-based segmentation model to automatically delineate tumors from full-body PET/CT images.
Methods:
PET/CT image pairs of 91 patients were collected for this...

Automated Multimodal Image Registration for Prostate Bed Radiation Treatment

Authors: Quan Chen, Xue Feng, Chunhui Han, Gaofeng Huang, Trevor Ketcherside, Yi Lao, Yun Rose Li, An Liu, Bo Liu, Kun Qing, William T. Watkins

Affiliation: Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, Department of Radiation Oncology, City of Hope National Medical Center, Mayo Clinic Arizona, Carina Medical LLC

Abstract Preview: Purpose: New treatment platforms such as Ethos (Varian Medical Systems) allow the introduction of multi-modal imaging into adaptive radiotherapy workflow to facilitate an up-to-date view of patients’ ...

Automated Parametric Custom Collimator Creation for Preclinical Irradiation Studies

Authors: Muhammad Ramish Ashraf, Dixin Chen, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner

Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: Precise beam collimation is essential in preclinical radiotherapy studies to ensure accurate dose delivery. Manual design and fabrication of organ-specific collimators usually consist of mult...

Deep Learning-Based Auto-Segmentation in Cervical High-Dose-Rate Brachytherapy with Clinical Considerations

Authors: Benjamin Haibe-Kains, Ruiyan Ni, Alexandra Rink

Affiliation: Department of Medical Biophysics, University of Toronto, University Health Network

Abstract Preview: Purpose: Accurate auto-segmentation for targets and organs-at-risk (OARs) using deep learning reduces the delineating time in radiotherapy. In high-dose-rate brachytherapy, specific clinical criteria ...

Developing a Dataset for Investigations into the Impact of CT Acquisition and Reconstruction Conditions on Quantitative Imaging Using Paired Image Quality and Radiomics Phantom Data

Authors: Morgan A. Daly, David J. Goodenough, Andrew M. Hernandez, John M. Hoffman, Joshua Levy, Michael F. McNitt-Gray, Ali Uneri, Bino Varghese

Affiliation: University of California, George Washington University, David Geffen School of Medicine at UCLA, Johns Hopkins Univ, University of Southern California, The Phantom Laboratory

Abstract Preview: Purpose: Quantitative imaging is affected by CT acquisition and reconstruction conditions, limiting robustness in multi-site or -scanner studies. This work aimed to develop a dataset that will enable ...

Development of a Knowledge-Based Planning Model for Optimal Trade-Off Guidance in Locally Advanced Non-Small Cell Lung Cancer

Authors: Ming Chao, Hao Guo, Tenzin Kunkyab, Yang Lei, Tian Liu, Kenneth Rosenzweig, Robert Samstein, James Tam, Junyi Xia, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai

Abstract Preview: Purpose:
The aim of the study is to develop a trade-off prediction model to efficiently guide the treatment planning process for patients with stage III non-small cell lung cancer (NSCLC).
Metho...

Dosimetric Assessment of Multicriteria Optimization for Accelerated Partial Breast Irradiation (APBI)

Authors: Alyssa Gadsby, William J. Godwin, Jennifer L. Harper, Daniel G. McDonald, Jean L. Peng, Alek K. Rapchak, Sean A Roles, Austin M. Skinner, Stephanie Tan

Affiliation: Medical University of South Carolina

Abstract Preview: Purpose: Multi-Criteria Optimization (MCO) theoretically allows for increased dose control during optimization. This study is the first to compare standard optimization (SO) and MCO for accelerated pa...

Dosimetric Assessment of Simultaneous Multi-Energy and Fluence Optimization for IMRT and VMAT

Authors: Aliasghar Rohani, Rui Zhang

Affiliation: Louisiana State University, Baton Rouge, Louisiana, Department of Radiation Oncology, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: This study aimed to evaluate the impact of simultaneous optimization of multi-photon beam energy and fluence on IMRT and VMAT treatment planning.
Methods: An Elekta linear accelerator (lin...

Dosinme: A 3D Visualization Platform for Internal Dosimetry and Radionuclide Behavior in Computational Human Phantoms

Authors: Lotem Buchbinder Shadur, Shaheen Dewji, Martin Graffigna, Alejandro Rafael Martinez, Emmanuel Mate-Kole, Antonio McClain, Samuel Taylor, Jeffrey Wang

Affiliation: Student, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology

Abstract Preview: Purpose: DosInMe is an internal dosimetry visualization tool developed by the Radiological Engineering, Detection, and Dosimetry Laboratory at Georgia Tech to assist researchers and professionals in v...

Efficient Denoising of Low-Statistic Influence Matrices Using a Diffusion Transformer-Based Framework for Adaptive Proton Therapy

Authors: Yuzhen Ding, Hongying Feng, Jason Michael Holmes, Baoxin Li, Wei Liu, Daniel Ma, Lisa McGee, Samir H. Patel, Jean Claude M. Rwigema, Sujay A. Vora

Affiliation: Arizona State University, Department of Radiation Oncology, Mayo Clinic, Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose:
Intensity-modulated proton therapy (IMPT) is a preferred treatment modality for head and neck (H&N) cancer patients, offering precise tumor targeting while sparing surrounding organs at ri...

Efficient FAST-Forward Planning Strategy for X-Ray Based Online Adaptive Radiotherapy

Authors: Prasanna Alluri, Mona Arbab, Xingzhe Li, Chang-Shiun Lin, Mu-han Lin, David D.M. Parsons, Asal Rahimi, Justin D. Visak, Narine Wandrey

Affiliation: UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX

Abstract Preview: Purpose: Intelligence-Optimization-Engine (IOE) v1.0 relied heavily on planner expertise and patient-specific IMRT beam arrangements, requiring frequent revisions. While VMAT workflows offered potenti...

Enhanced Pelvic Organ Segmentation Using LLM-Driven Prompts for Prostate Cancer Low-Dose-Rate Brachytherapy

Authors: Yang Lei, Tian Liu, Ren-Dih Sheu, Meysam Tavakoli, Jing Wang, Kaida Yang, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Emory University

Abstract Preview: Purpose:
The study aimed to improve target and organ at risk (OAR) segmentation in low-dose-rate brachytherapy (LDR-BT) for prostate cancer treatment, by integrating clinical guidelines into deep l...

Feasibility Study of Group Sparse-Based Beam Angle Optimization for Multi-Field Carbon Ion Radiotherapy

Authors: Min Cheol Han, Hojin Kim, Jin Sung Kim, Hyejin Lee, Sac Lee, Yongdo Yun

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine

Abstract Preview: Purpose: Carbon ion radiotherapy (CIRT) is characterized by high relative biological effectiveness (RBE), which must be integrated into the treatment planning process. This study aims to develop a nov...

Fully Automated Zero-Shot Organ Segmentation in Male Pelvic MR Images for MR-Guided Radiation Therapy

Authors: Jihun Kim, Jin Sung Kim, Jun Won Kim, Yong Tae Kim, Chanwoong Lee, Jihyn Pyo, Young Hun Yoon

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine

Abstract Preview: Purpose: Although segmentation foundation models have recently demonstrated promising zero-shot performance on natural images, its clinical application to magnetic resonance (MR) images still requires...

Impact analysis of effective dose conversion factors from CT scanner models

Authors: Max Chen, Sean Marquardt, Ben Yang, Kai Yang

Affiliation: Cary Academy, Massachusetts General Hospital, Winchester High School

Abstract Preview: Purpose: To analyze the impact of scanner model variation on the effective dose conversion factor (“k-factor”), which is most commonly used for CT effective dose calculation.

Methods: The stand...

Improvements of Lateral Penumbra at Various Depth Regions in Scanned Proton Treatment System with a Multi-Leaf Collimator: Dose Verifications and Plan Comparisons

Authors: Takahiro Kato, Teiji Nishio, Masataka Oita, Robabeh Rahimi, Yuki Tominaga, Yushi Wakisaka

Affiliation: University of Maryland, Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Medical Co. Hakuhokai, Osaka Proton Therapy Clinic, Medical Physics Laboratory, Division of Health Science, Osaka University Graduate School of Medicine, Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University

Abstract Preview: Purpose: This study evaluated dose verifications and lateral penumbra improvements for scanned proton therapy plans with and without a multi-leaf collimator (MLC) under various air gaps.
Methods: E...

Investigation of the Impact of Dlg Changes on Plan Quality and Patient Specific QA

Authors: Nicole C. Detorie, Steven M. Kirsner, Remy Y. Manigold

Affiliation: Scripps Cancer Center

Abstract Preview: Purpose:
Dosimetric Leaf Gap (DLG) is an important factor in obtaining the proper beam model in the Eclipse treatment planning system. The purpose of this study was to investigate the dosimetric im...

Lu-PSMA-Dose, a French Retrospective Multicentric Dosimetry Study of 177Lu-PSMA Treatments for Metastatic Castration-Resistant Prostate Cancer

Authors: NadÚge Anizan, Jean-Noël Badel, Thomas Baudier, David Broggio, Désirée Deandreis, Ludovic Ferrer, Didier Franck, Camilo Garcia, Jean Gasteuil, Anne-Laure Giraudet, Olivier Humbert, Laetitia Imbert, Malick Koulibaly, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard, Caroline Rousseau, Guido Rovera, David Sarrut, Paul Schwartz, Nicolas Varmenot

Affiliation: Institut de CancĂ©rologie de l’Ouest, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de Physique MĂ©dicale, Institut BergoniĂ©, Service de Physique MĂ©dicale, CHRU de Nancy Brabois, Service de MĂ©decine NuclĂ©aire, Centre de lutte contre le cancer LĂ©on BĂ©rard, UniversitĂ© de Lyon, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, UniversitĂ© Nice CĂŽte d’Azur, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de MĂ©decine NuclĂ©aire, Institut de CancĂ©rologie de l’Ouest, Service de Physique MĂ©dicale, Service de MĂ©decine NuclĂ©aire, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon; Centre de lutte contre le cancer LĂ©on BĂ©rard, Institut BergoniĂ©, Service de MĂ©decine NuclĂ©aire

Abstract Preview: Purpose: The main objective of the Lu-PSMA-Dose study, sponsored by ASNR, is to estimate retrospectively the individual absorbed dose delivered to patients treated with 177Lu-PSMA for metastatic castr...

Multi-Institutional Analysis of CT Dose Index Variability and Radiomics Features

Authors: Caroline Chung, Michael Knopp, Stephen F. Kry, Hunter S. Mehrens, John Rong

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, University of Cincinnati

Abstract Preview: Purpose: To evaluate the variability of CT dose index (CTDIvol) and radiomics features across a large cohort of radiotherapy simulation CT scans from multiple institutions.
Methods: Three IROC phan...

Multi-Organ Segmentation of Pelvic Cone-Beam Computed Tomography (CBCT) with Transformer Models to Enhance Adaptive Radiotherapy for Prostate Cancer

Authors: Ming Chao, Thomas Chum, Tenzin Kunkyab, Yang Lei, Tian Liu, Richard G Stock, Hasan Wazir, Junyi Xia, Jiahan Zhang

Affiliation: Icahn School of Medicine at Mount Sinai

Abstract Preview: Purpose:
This study aims to develop effective strategies for multi-organ segmentation of pelvic cone-beam computed tomography (CBCT) images based on transformer models to facilitate adaptive radiat...

Multi-Scale, Multi-Task Framework with Jacobian Descent for Multi-Plan Dose Prediction in Sequential Boost Radiotherapy

Authors: Steve B. Jiang, Mu-Han Lin, Yu-Chen Lin, Austen Matthew Maniscalco, Dan Nguyen, David Sher, Xinran Zhong

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, UT Dallas

Abstract Preview: Purpose:
Sequential boost radiotherapy (RT) poses a challenge in allocating dose across multiple plans while protecting organs at risk (OARs). Clinicians must decide whether OAR sparing should occu...

Multi-Variat, Multi-Model, and Multi-Patient: From Pure Feasibility to Generalizability in Machine Learning Outcome Prediction Model-Based Treatment Plan Optimization

Authors: Martin Frank, Oliver JĂ€kel, Niklas Wahl

Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Karlsruhe Institute of Technology (KIT)

Abstract Preview: Purpose: Machine learning (ML) models on normal tissue complication and tumor control probability ((N)TCP) exploiting e.g. dosiomic and radiomic features are playing an increasingly important role in ...

Multi-Vendor Validation of a Deep Learning-Based Synthetic CT Generation Model for MR-Only Radiotherapy Planning in the Pelvis

Authors: Gregory Bolard, Rabten Datsang, Sarah Ghandour, Timo Kiljunen, Pauliina Paavilainen, Sami Suilamo, Katlin Tiigi

Affiliation: Turku University Hospital, Virginia Commonwealth University, MVision AI, North Estonia Medical Centre, Docrates Cancer Center, Hopital Riviera-Chablais

Abstract Preview: Purpose: To verify the performance of a vendor-neutral deep learning model for synthetic CT generation from T2-weighted and balanced steady-state MR sequences to support both MR-only simulation and MR...

Multimodal Framework for Predicting Radiation-Induced Severe Acute Esophagitis in Esophageal Cancer

Authors: Yeona Cho, Chloe Min Seo Choi, Joseph O. Deasy, Jue Jiang, Jihun Kim, Jin Sung Kim, Nikhil Mankuzhy, Aneesh Rangnekar, Andreas Rimner, Maria Thor, Harini Veeraraghavan, Abraham Wu

Affiliation: University of Freibrug, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Memorial Sloan Kettering Cancer Center, Yonsei University

Abstract Preview: Purpose: We hypothesized that combining clinical, imaging, and radiotherapy dose-distribution features could increase predictive model accuracy in radiation-induced severe acute esophagitis (SAE) in e...

Noise Sensitivity of Benchmark Whole-Body CT Segmentation Models: Totalsegmentator and Vista3D Performance on an Independent Dataset

Authors: Samuel L. Brady, Shruti Hegde, Alexander Knapp, Usman Mahmood, Joseph G. Meier, Elanchezhian Somasundaram, Zachary Taylor

Affiliation: Cincinnati Children's Hospital Medical Ctr, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Cincinnati Children's Hospital Medical Center, Cincinnati Childrens Hospital Med Ctr

Abstract Preview: Purpose:
To assess how two benchmark multi-organ CT segmentation models respond to varying image noise levels.
Methods:
This study utilized the pediatric CT dataset from The Cancer Imaging Ar...

Novel Approach to Improve Treatment Planning Process for Mixed Fractionation Schemes on ZAP-X

Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang

Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center

Abstract Preview: Purpose: Using mixed fractionation schemes is a common technique in treating CNS lesions. This article describes an innovative plan-and-split approach for more efficient planning on the ZAP-X and thus...

Optimized Dosimetric Planning for Trigeminal Neuralgia Using Cyberknife S7 Precision TPS with Volo Optimizer

Authors: Amy Fitzpatrick, Kim Howard, Julius G. Ojwang, Neelu Soni

Affiliation: Mercy Hospital Springfield

Abstract Preview: Purpose: This study evaluates the dosimetric advantages and workflow improvements of the CyberKnife S7 Precision Treatment Planning System (TPS) with the VOLO optimizer for stereotactic radiosurgery (...

Patient-Specific Imaging Modality Agnostic Virtual Digital Twins Modeling Temporally Varying Digestive Motion

Authors: James M. Balter, Lando S. Bosma, Jorge Tapias Gomez, Nishant Nadkarni, Mert R Sanbuncu, William Paul Segars, Ergys D. Subashi, Neelam Tyagi, Harini Veeraraghavan

Affiliation: University of Michigan, The University of Texas MD Anderson Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Cornell University, University Medical Center Utrecht, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Develop patient-specific virtual digital twin (VDT) cohorts modeling physically realistic spatio-temporal gastrointestinal (GI) organs (stomach and duodenum) digestive motion.
Methods: Pat...

Proton Therapy Treatment Planning for Thoracic Cancer: A Comparative Analysis of Single and Multi-Field Plans

Authors: Gueorgui Gueorguiev, Kavya Thaniyarasu

Affiliation: University of Bologna, National Centre of Radiobiology and Radiation Protection

Abstract Preview: Purpose: This study investigates the clinical viability of double scattering proton therapy treatment planning for thoracic malignancies using single or multiple treatment fields. The aim of this stud...

Quantifying Uncertainties in Radiation Risk and Performance-Based Clinical Risk Assessment in Clinical Computed Tomography

Authors: Em Harkness, Francesco Ria, Ehsan Samei

Affiliation: Duke University, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System

Abstract Preview: Purpose:
A recently introduced mathematical method quantifies performance-based clinical risk to create a risk-to-risk assessment with radiation risk, rendering the so-called total risk. However, t...

Real-Time 3D Dose Verification for MR-Guided Online Adaptive Radiotherapy (ART) Via Geometry-Encoded Deep Learning Framework

Authors: Steve B. Jiang, Dan Nguyen, Chenyang Shen, Fan-Chi F. Su, Jiacheng Xie, Shunyu Yan, Daniel Yang, Ying Zhang, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas

Abstract Preview: Purpose: Fast dose verification is essential for the safety and efficiency of MR-guided adaptive radiotherapy (ART) as patients anxiously waiting on the treatment couch. Conventional tools often requi...

Redefining the Down-Sampling Scheme of U-Net for Precision Biomedical Image Segmentation

Authors: Yizheng Chen, Md Tauhidul Islam, Mingjie Li, Lei Xing

Affiliation: Department of Radiation Oncology, Stanford University

Abstract Preview: Purpose:
Biomedical image segmentation (BIS) is a cornerstone of medical physics, enabling accurate delineation of anatomical structures and abnormalities, which is critical for diagnosis, treatmen...

Reducing Variable Rbe in Oars for HN, Breast, and Prostate Proton Therapy Using a Scripted Spot-Delete Technique

Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey

Affiliation: Thompson Proton Center

Abstract Preview: Purpose: Linear energy transfer (LET) and variable relative biological effectiveness (RBE) evaluation are important steps in the future of proton therapy, moving beyond RBE=1.1 for all treatment plann...

Reinforcement Learning Based Machine Parameter Optimization for Two-Arc Prostate VMAT Planning

Authors: William T. Hrinivich, Junghoon Lee, Lina Mekki

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Biomedical Engineering, Johns Hopkins University, Johns Hopkins University

Abstract Preview: Purpose: Volumetric modulated arc therapy (VMAT) planning is a computationally expensive process. In this work, we propose a reinforcement learning (RL) framework to automatically optimize dose rate a...

Research on Multi-Organ Segmentation Based on Cross-Domain Transfer Learning

Authors: Jiali Gong, Yi Guo, Chi Han, Wanli Huo, Hongdong Liu, Zhao Peng, Yaping Qi, Zhaojuan Zhang

Affiliation: Department of Radiotherapy, cancer center, The First Affiliated Hospital of Fujian Medical University, Department of Oncology, Xiangya Hospital, Central South University, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, China Jiliang University, Division of lonizing Radiation Metrology, National Institute of Metrology, Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province, College of Information Engineering, China Jiliang University, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University

Abstract Preview: Purpose: To address overfitting from limited training data in multi-organ segmentation, an efficient transfer learning framework is proposed. It reduces reliance on training samples, enabling a single...

Robust and Radiobiologically Accurate Dose Summation Strategy for Multiple Courses of Stereotactic Re-Irradiation of Metastatic Brain Cancer Patients with Previous WBRT

Authors: Garrett Russell Hamilton, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Recurrent brain metastasis is very common, and patients who previously received whole-brain radiotherapy (WBRT) may receive an additional course(s) of stereotactic radiosurgery (SRS) to selec...

Standardized Immobilization and Setup Procedure Improves Accuracy of Multi-Time Point SPECT/CT Image Registration for Radiopharmaceutical Therapy (RPT) Dosimetry

Authors: Bryan Bednarz, Laura Bennett, Abby E. Besemer, Tyler J Bradshaw, Steve Y Cho, John M. Floberg, Joseph Grudzinski, Elissa Khoudary, Michael J. Lawless

Affiliation: Department of Radiology, University of Wisconsin, University of Wisconsin-Madison Department of Medical Physics, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Voximetry, Inc, University of Pennsylvania, Department of Radiology, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: To assess the impact of using a standardized immobilization setup for multi-time-point SPECT/CT imaging on radiopharmaceutical therapy (RPT) dosimetry image registration.

Methods: Ten ...

Tackling the Challenge of Multi-Target Metastases Treatment: Evaluation of Ethos Treatment Planning System

Authors: Avery Antes, Bulent Aydogan, Rama Chicfeh, Erik Pearson, Neslihan Sarigul

Affiliation: The University Of Chicago, The University of Chicago

Abstract Preview: Purpose: This study evaluates the performance of the Ethos Treatment Planning System (TPS) in managing oligometastatic cancer patients previously treated using multiple isocenter plans.
Methods: Th...

Targeted Multi-Criteria Optimization for Rapid Improvement of Organ-at-Risk Dose in the Setting of Prostate Stereotactic Body Radiation Therapy

Authors: Alyssa Gadsby, William J. Godwin, Daniel G. McDonald, Jean L. Peng, Alek K. Rapchak, Sean A Roles, Austin M. Skinner, Stephanie Tan

Affiliation: Medical University of South Carolina

Abstract Preview: Purpose: To utilize multi-criteria optimization (MCO) in a targeted fashion to quickly and easily improve dose to the rectum when treating the prostate with stereotactic body radiation therapy (SBRT)....

Uncertainty-Guided Cross-Domain Adaptation for Unsupervised Medical Image Segmentation

Authors: Yunxiang Li, Weiguo Lu, Xiaoxue Qian, Hua-Chieh Shao, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Curating high-quality, labeled data for medical image segmentation can be challenging and costly, considering the existence of various image domains with differing modalities/protocols. Cr...

Using Open-Source Reasoning Large Language Models for Radiotherapy Structure Name Harmonization

Authors: Claus Belka, Stefanie Corradini, Christopher Kurz, Guillaume Landry, Matteo Maspero, Adrian Thummerer, Erik van der Bijl

Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Radboud University Medical Center, UMC Utrecht

Abstract Preview: Purpose: To automatically harmonize non-standardized organ-at-risk (OAR) structure names from multi-lingual, multi-institutional radiotherapy datasets using state-of-the-art open-source reasoning larg...