Authors: Yao Hao, Pamela Samson, Ziyu Shu, David Zhang, Tiezhi Zhang, Jingxuan Zhu
Affiliation: Stony Brook University, Washington University in St. Louis, Washington University School of Medicine, WashU Medicine
Abstract Preview: Purpose: The aim of this study is to validate the feasibility of using millimeter wave (mmWave) radar for phase binning 4D-CT by concurrent, non-contact phase tracking of respiratory and cardiac wavef...
Authors: Jingyuan Chen, Sheng Li, Tianming Liu, Wei Liu, Zhengliang Liu, Zhong Liu, Daniel Ma, Samir H. Patel, Guangya Wang, Yunze Yang
Affiliation: University of Miami, Mayo Clinic, School of Data Science, University of Virginia, School of Computing, University of Georgia, Department of Radiation Oncology, Mayo Clinic, Institute of Western China Economic Research, Southwestern University of Finance and Economics
Abstract Preview: Purpose:
Traditional patient outcome analyses relied heavily on conventional statistical models that primarily elucidate correlation rather than causal relationships. In this study, we aim to ident...
Authors: Alonso N. Gutierrez, Daniel E. Hyer, Blake R. Smith
Affiliation: Miami Cancer Institute, Baptist Health South Florida, Iowa Health Care, University of Iowa
Abstract Preview: Purpose: To perform a feasibility study of optimizing and producing a compact range compensator to deliver single-energy pencil beam scanning (PBS) proton arc therapy treatments. Omitting energy chang...
Authors: Edward D. Brandner, Weihua Fu, M. Saiful Huq, Ronald John Lalonde, Kiran Mehta, Hima Bindu Musunuru, Yongqian Zhang
Affiliation: UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman CancerCenter
Abstract Preview: Purpose: Treatment of diffuse and extensive involvement of the skull by malignancy presents a difficult challenge for radiation therapy. This study reports preliminary experience of a modified volumet...
Authors: Laura Bennett, Wesley S. Culberson, Albert Du, Kevin J. Erhart, Ryan T. Flynn, Ryan Gardner, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Eric Jensen, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake
Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Ion Beam Applications (IBA), University of Iowa, Iowa Health Care, .decimal
Abstract Preview: Purpose: To develop and experimentally validate a novel Monte Carlo (MC) framework designed to enable calculation-based quality assurance (QA) for collimated intensity modulated proton therapy treatme...
Authors: Wenhua Cao, Hadis Moazami Goudarzi, Madison Emily Grayson, Zongsheng Hu, Gino Lim, Steven Hsesheng Lin, Radhe Mohan
Affiliation: The University of Texas MD Anderson Cancer Center, Department of Industrial Engineering, University of Houston, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Proton Arc Therapy (PAT) offers significant potential in treating complex cancer cases by delivering a continuous radiation dose as the gantry rotates. This study aims to investigate the pote...
Authors: John Bennet, Indrin J. Chetty, Tai H. Dou
Affiliation: Department of Radiation Oncology,Cedars Sinai Medical Center, Department of Radiation Oncology, Cedars Sinai Medical Center, Department of Radiation Oncology,Cedars-Sinai Medical Center
Abstract Preview: Purpose:
To investigate the effect of complexity of stereotactic radiosurgery (SRS) volumetric modulated arc therapy plans on gamma pass rates (GPR) using a novel high-resolution ion chamber array ...
Authors: Joyoni Dey, Hunter Cole Meyer, Murtuza Taqi
Affiliation: Louisiana State University
Abstract Preview: Purpose: We propose using super-resolution methods for X-ray grating interferometry without an analyzer with detectors that fail to meet the Nyquist sampling rate needed for traditional image recovery...
Authors: Richard Lesieur, Olivia Magneson, David E. Solis, Sotirios Stathakis
Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center
Abstract Preview: Purpose: This study evaluates the deliverability and precision of multileaf collimator (MLC) positioning in treatment plans generated by two different Treatment Planning Systems (TPS), Monaco and Pinn...
Authors: David J. Gladstone, P. Jack Hoopes, David I Hunter, Brian W Pogue, Jacob Pierce Sunnerberg, Armin Tavakkoli
Affiliation: Thayer School of Engineering, Dartmouth College, University of Wisconsin - Madison, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Geisel School of Medicine, Dartmouth College
Abstract Preview: Purpose: The FLASH effect, characterized by normal tissue sparing under ultra-high dose rate (UHDR) radiation delivery, remains mechanistically unclear. This study investigated the relationship betwee...
Authors: Yabo Fu, Yang Lei, Yu Lei, Haibo Lin, Ruirui Liu, Tian Liu, Kenneth Rosenzweig, Charles B. Simone, Shouyi Wei, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York Proton Center
Abstract Preview: Purpose: Beam orientation optimization (BOO) in intensity-modulated radiation therapy (IMRT) is traditionally a complex, non-convex problem tackled with heuristic methods. This study benchmarks global...
Authors: Austen N. Curcuru, Arash Darafsheh, Winter Green, Yao Hao, Baozhou Sun, Tiezhi Zhang, Tianyu Zhao, Xiandong Zhao
Affiliation: WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Washington University in St. Louis, University of South Florida, Baylor College of Medicine
Abstract Preview: Purpose: Intensity modulated proton therapy (IMPT) requires precise setup imaging due to the sharp dose gradients and rapid distal fall-off seen in proton therapy dose distributions. Additionally, onl...
Authors: Kaile Li, Esmail Parsai
Affiliation: Alexander T. Augusta Military Medical Center, Alexander T. Augusta Miliary Medical Center
Abstract Preview: Purpose: To evaluate the sensitivity of the portal dosimetry system with the Arc CHECK system at identical Volumetric Modulated Arc Therapy (VMAT) setup
Methods: An Arc CHECK system from Sun Nuclea...
Authors: Tetsuo Fukuda, Hideaki Hirashima, Kohei Kawata, Yukako Kishigami, Takashi Mizowaki, Mitsuhiro Nakamura, Yohei Sawada, Maika Urago
Affiliation: Kyoto University, kyotoUnivercity, Hitachi high-tech, Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University
Abstract Preview: Purpose: To present the comprehensive commissioning results of the O-ring shaped linac, OXRAY.
Materials and Methods: OXRAY enables a novel three-dimensional unicursal noncoplanar irradiation metho...
Authors: Angela Gathers, Christina Henson, Sakuntala Jagabattuni, Mark A. Newpower
Affiliation: University of Oklahoma HSC, Department of Otolaryngology, University of Oklahoma HSC, University of Oklahoma Health Sciences Center
Abstract Preview: Purpose: A previous departmental study showed an increase in ototoxicity (hearing loss) rates in head & neck cancer (HNC) patients treated with Intensity Modulated Proton Therapy (IMPT) vs. x-ray radi...
Authors: Parker Anderson, Elizabeth L. Bossart, Jonathan Cyriac, Nesrin Dogan, Robert Kaderka, Yihang Xu
Affiliation: University of Miami, University of Miami, Sylvester Comprehensive Cancer Center, University of Miami Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose:
Knowledge-based planning (KBP) can enhance the treatment planning process in cancer radiotherapy (RT). By training a KBP model with high-quality treatment plans developed by experts, dose-...
Authors: Ming Chao, Hao Guo, Tenzin Kunkyab, Yang Lei, Tian Liu, Kenneth Rosenzweig, Robert Samstein, James Tam, Junyi Xia, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai
Abstract Preview: Purpose:
The aim of the study is to develop a trade-off prediction model to efficiently guide the treatment planning process for patients with stage III non-small cell lung cancer (NSCLC).
Metho...
Authors: Dr. Sheaka Alobaidli, Anju K V, Dr. Chiranjib Konar, Sreejesh MS, Dr. Vijayaprabhu N, Dr. Deepti Sharma, Dr. Hanuman Prasad Yadav
Affiliation: Amity Institute of Applied Sciences, Kuwait Cancer Control Center, Institute of Liver and Biliary Sciences, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Amity institute of Applied Sciences, Amity University, Institute of Liver and Biliary Sciences(ILBS)
Abstract Preview: Purpose:
The accuracy of dose delivery in stereotactic body radiotherapy (SBRT) is critical for effectively treating hepatocellular carcinoma (HCC). This study aims to develop patient-specific 3D-p...
Authors: Grant Evans, Maxwell Arthur Kassel, Charles Shang, Michael H. Shang, Stephen Shang, Timothy R Williams
Affiliation: South Florida Proton Therapy Institute, SFPRF, Department of Radiation Medicine, MedStar Georgetown University Hospital
Abstract Preview: Purpose:
Daily image guidance for head and neck intensity-modulated proton therapy (IMPT) presents significant challenges due to large target volumes and anatomical changes. Geometric deviations al...
Authors: Stephen D. Davis, Alonso N. Gutierrez, Noah S. Kalman, Michael Leyva, Alejandro Rene Llanes Lopez, William Romaguera, Ranjini P. Tolakanahalli, Deborah Wang
Affiliation: Miami Cancer Institute, Baptist Health South Florida, Miami Cancer Institute, Miami Cancer Institute, Baptist Health
Abstract Preview: Purpose: To evaluate whether a modulated electron bolus (MEB) technique improves both nominal and shifted dose distributions in nasal electron therapy as compared to a non‑modulated, uniform‑thickness...
Authors: Nan Li, Yaoying Liu, Shouping Xu, Gaolong Zhang
Affiliation: Department of Radiation Oncology, School of Physics, Beihang University, School of physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Abstract Preview: Purpose: In intensity-modulated proton therapy (IMPT) for head and neck cancer, CBCT registration ensures accurate setup, minimizing dose errors. Unlike IMRT, IMPT plans directly define tumor volumes ...
Authors: Stella Flampouri, Edgar Gelover, William Andrew LePain, Roelf L. Slopsema, Alexander Stanforth, Mingyao Zhu
Affiliation: Emory Healthcare, Emory University
Abstract Preview: Purpose: Little consideration was given to the change in dose rate (DR) observed when moving to pencil beam scanning (PBS). This study reports on DR in clinical prostate PBS plans. While dose distribu...
Authors: Chia-Lung Chien, Wen C. Hsi, Romy Megahed, Kayla Schneider
Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiation Oncology, University of Arkansas for Medical Sciences
Abstract Preview: Purpose:
The dosimetric variations induced by inter-fractional anatomical changes in intensity-modulated proton therapy could impact the clinic outcomes for head-and-neck (HN) cancer patients. This...
Authors: Pat Esposito, Ashley Klein, Carmine Verna, Ling Zhuang
Affiliation: Northwestern Medicine
Abstract Preview: Purpose: To evaluate dosimetric parameters and treatment delivery efficiency between volumetric modulated arc therapy (VMAT) and hybrid dynamic conformal arc (HDCA) on SRS and SBRT planning through st...
Authors: Chunhui Han, An Liu, Anthony Magliari, Lesley Rosa
Affiliation: Office of Medical Affairs, Varian, A Siemens Healthineers Company, Department of Radiation Oncology, City of Hope National Medical Center
Abstract Preview: Purpose: To evaluate the performance of a knowledge-based planning (KBP) optimization model for total marrow and lymphoid irradiation (TMLI) on a ring-gantry linac with a dual-layer MLC and to evaluat...
Authors: Yang Sheng, Qingrong Jackie Wu, Qiuwen Wu, Xin Wu, Dongrong Yang
Affiliation: Duke University Medical Center
Abstract Preview: Purpose:
Treatment planning for intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) relies on inverse planning, an iterative and non-intuitive process of adjust...
Authors: Shen Fu, Jun Hou, Zuofeng LI, Taize Yuan, Qingyuan Zhang, Yuanshui Zheng
Affiliation: GuangZhou Concord Cancer Center, Guangzhou Concord Cancer Center, 广州泰和肿瘤医院
Abstract Preview: Purpose: A visual feedback system is beneficial for patients to maintain consistent respiratory signal during gated radiotherapy, especially for intensity modulated proton therapy (IMPT) where motion ...
Authors: Ryan Clark, Jon Cornelisse, Kenny Guida, Anthony Magliari, Lesley Rosa, Megan Smith, Shane R Stecklein
Affiliation: Office of Medical Affairs, Varian, A Siemens Healthineers Company, Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Post-mastectomy radiation therapy (PMRT) can pose a challenge for planners of all levels of experience. For cases where 3D conformal therapy yields undesirable results (i.e., dose heterogenei...
Authors: Xun Jia, Youfang Lai
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University
Abstract Preview: Purpose: Ultrahigh dose rate FLASH (>40 Gy/s) radiotherapy (RT) has attracted significant attention. The mechanism remains unclear, hindering clinical translation. This study investigated the behavior...
Authors: Omer Gal, Alonso N. Gutierrez, Matthew D. Hall, Rupesh Kotecha, Minesh P. Mehta, Andrew J. Wroe, Jen Yu
Affiliation: Miami Cancer Institute, Baptist Health South Florida
Abstract Preview: Purpose: Linear energy transfer (LET) is directly related to relative-biological-effectiveness dose in proton therapy. This study aims to investigate how the treatment field hinge angles affect LET of...
Authors: Gregory A Azzam, Michael Butkus, Nesrin Dogan, Robert Kaderka, Nhan Vu, Yihang Xu
Affiliation: University of Miami, Department of Radiation Oncology, University of Miami, University of Miami Sylvester Comprehensive Cancer Center, University of Miami, Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose: Knowledge-based planning (KBP) has demonstrated potential for improving planning quality and efficiency. Adoption of KBP in particle therapy has been slow due to limited number of plans to tr...
Authors: Yang Sheng, Qingrong Jackie Wu, Qiuwen Wu, Xin Wu, Dongrong Yang
Affiliation: Duke University Medical Center
Abstract Preview: Purpose:
This study aims to leverage large language model (LLMs) to develop a human-in-the-loop agentic framework, enhancing the efficiency of treatment planning in radiotherapy.
Methods:
A L...
Authors: Sina Mossahebi, Pouya Sabouri, Kayla Schneider, James W Snider
Affiliation: University of Maryland School of Medicine, Proton International, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiation Oncology, University of Arkansas for Medical Sciences
Abstract Preview: Purpose:
Conventional patient-specific QA (PSQA) for intensity-modulated proton therapy (IMPT) requires extensive measurements, straining resources in single-room proton centers. This study evaluat...
Authors: Shahed Badiyan, Chien-Yi Liao, Mu-Han Lin, David D.M. Parsons, Justin D. Visak, Brien Timothy Washington, Kenneth Westover, Yuanyuan Zhang
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX
Abstract Preview: Purpose: Adaptive radiotherapy (ART) programs are resource-intensive due to their technical complexities, requiring highly skilled planners. Leveraging integrated automated treatment planning system (...
Authors: Wesley S. Culberson, Albert Du, Ryan T. Flynn, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake
Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Iowa, Iowa Health Care
Abstract Preview: Purpose:
To perform end-to-end treatment planning and delivery verification of energy-specific collimated treatments optimized to achieve the maximum obtainable high-dose conformity using the dynam...
Authors: MacKenzie Rachelle Coon, Justin Geise, Judith Noemi Rivera, Matthew L. Scarpelli, Jessica Leigh Veenstra, Chandler Zaugg
Affiliation: Purdue University, Indiana University
Abstract Preview: Purpose: Glioblastoma (GBM) is among the most aggressive and treatment-resistant cancers due to its immunosuppressive tumor microenvironment. Immunotherapy holds promise for GBM treatment, but its eff...
Authors: Indra J. Das, Ahtesham U. Khan, Andrew J. White, Poonam Yadav
Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine
Abstract Preview: Purpose: During intensity modulated radiotherapy (IMRT) planning, low MU segments (< 3 MU) are commonly avoided due to documented dosimetric nonlinearity and poor reproducibility. This work aims to ex...
Authors: Qihui Lyu, Dan Ruan, Ke Sheng, Jingjie Yu
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California, San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose: The robotic arm radiotherapy platform enables flexible delivery of non-coplanar and non-isocentric radiotherapy with variable Source-to-Isocenter Distances (SIDs). However, the high degrees o...
Authors: Peng Dong, Lei Xing
Affiliation: Department of Radiation Oncology, Stanford University, Stanford University
Abstract Preview: Purpose: Volumetric Modulated Arc Therapy (VMAT) optimization is a complex, non-convex problem with numerous variables and intricate constraints. Traditional optimization methods often lack efficiency...
Authors: Chia-Lung Chien, Wen C. Hsi, Faraz Kalantari, Pouya Sabouri, Man Yam
Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)
Abstract Preview: Purpose:
Reducing treatment delivery time is critical to improving patient throughput and minimizing the risk of intrafraction motion, which can compromise treatment accuracy. This study identifies...
Authors: Julien Bancheri, Chau Giang Bui, David G Cooke, Christopher M Lund, Morgan J Maher, Jan P. Seuntjens, Jason Z Yuan
Affiliation: Princess Margaret Cancer Centre & University of Toronto, Medical Biophysics, University of Toronto, University of Toronto, Medical Physics Unit, McGill University, Department of Physics, McGill University
Abstract Preview: Purpose: The dielectric wall accelerator (DWA) offers a low-cost solution for proton therapy, using non-resonant waveguides to accelerate particles. Radial waveguides (RWGs), consisting of a dielectri...
Authors: Dante PI Capaldi, Lu Jiang, Qihui Lyu, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Preclinical small animal studies help understand radiation-induced biological responses, toxicities, and mechanisms, facilitating the translation of new therapies to patient treatment. Int...
Authors: Guang-Pei Chen, Renae Conlin, Juan A. Garcia-Alvarez, Kirk Morris, Haidy G. Nasief, Eenas A. Omari, Eric S. Paulson
Affiliation: Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: Cumulative dose limits make replacing and calibrating Metal Oxide Semiconductor Field Effect dosimeters (MOSFET-d) used for in-vivo dosimetry a common clinical task. Calibration protocols for...
Authors: Michael Armstrong, Courtney R. Buckey, Quan Chen, Suzanne J. Chungbin, Mirek Fatyga, Yi Rong, Jun Tan, Xiang Sheng Yan
Affiliation: Mayo Clinic Arizona, Mayo Clinic
Abstract Preview: Purpose: To model a commercial rotational table in treatment planning system (TPS) for accurate dose optimization and calculation.
Methods: A commercial rotational table (CDR Equilibrium®) is r...
Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Zi Yang, Kangning Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: Dose prediction (DP) is essential in guiding radiotherapy planning. However, current DP models for intensity-modulated radiation therapy (IMRT) primarily rely on fixed-beam orientations and a...