Authors: Odunola Grace Babawale, B. Gino Fallone, Alireza Gazor, Andrei D. Ghila, Patricia A. K. Oliver, Michael W. Reynolds, Keith D. Wachowicz, Tania Rosalia Wood, Shima Y. Tari, Eugene Yip, Jihyun Yun
Affiliation: Nova Scotia Health, Dept. of Medical Physics and Dalhousie University, Dept. of Physics and Atmospheric Science, Dept. of Radiation Oncology, Dept. of Medical Physics, Cross Cancer Institute and Dept. of Oncology, University of Alberta; MagnetTx Oncology Solutions, www.magnetTX.com, Department of Medical Physics, Arthur J. E. Child Comprehensive Cancer Centre, Dept. of Medical Physics, Cross Cancer Institute and Dept. of Oncology, University of Alberta, Department of Medical Physics, BC Cancer, Medical Physics Division, Department of Oncology, University of Alberta and Department of Medical Physics, Cross Cancer Institute
Abstract Preview: Purpose: To evaluate the dose to a moving target and its surroundings in a magnetic field using 4D-Monte-Carlo (MC) simulation.
Methods: The study utilizes a previously validated MC model of our li...
Authors: Ramin Abolfath, Sedigheh Fardirad, Abbas Ghasemizad, Houda Kacem, Marie Catherine Vozenin
Affiliation: University of Guilan, Universite de Lausanne, University Hospital, Geneva, Howard University
Abstract Preview: Purpose: Lower production of H2O2 in water is a hallmark of ultra-high dose rate (UHDR) compared to the conventional dose rate (CDR). The current computational models are in the opposite of the experi...
Authors: Sung Woon Choi, Dong Wook Kim, Jin Sung Kim, Na Hye Kwon, Paulo Jorge Ribeiro Da Fonte
Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Coimbra Institute of Engineering, Polytechnic University of Coimbra
Abstract Preview: Purpose: In hadrontherapy, such as proton and carbon ion therapy, it is desirable, for quality assurance reasons, to have an online beam energy measurement independent from the machine parameters. Sin...
Authors: Raneem Atta, Alejandro Bertolet, Mislav Bobić, Wesley E. Bolch, Robert Joseph Dawson, Carlos Huesa-Berral, Harald Paganetti, Eric Wehrenberg-Klee
Affiliation: Massachusetts General Hospital, University of Florida, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Representations of intra-organ vasculature have a variety of uses in the field of computational dosimetry but generally rely on models derived from population-averaged reference individuals. ...
Authors: Wesley E. Bolch, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Lazaro Fuentes Alfonso, Shreya P. Pathak, Julia D. Withrow
Affiliation: University of Florida
Abstract Preview: Purpose: To develop tetrahedral mesh-based tissue models within the breasts of the International Commission on Radiological Protection (ICRP) adult female mesh-type reference computational phantom (AF...
Authors: Mu-Han Lin
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: The rapid expansion of AI in Radiation Oncology is reshaping patient care, treatment planning, and institutional investments. Yet, with no standardized framework for evaluating cost-effectiveness, saf...
Authors: John P. Aris, Wesley E. Bolch, Robert Joseph Dawson, Bonnie N. C. President, Yitian Wang
Affiliation: Johns Hopkins University, University of Florida
Abstract Preview: Purpose: Generation of a mesh-based microscale lung model is essential for accurate dosimetry analysis. Lungs exchange air with the environment and may be exposed to alpha-particle-emitting radionucli...
Authors: Shae Gans, Carri K. Glide-Hurst, Mark Pankuch, Chase Ruff, Niek Schreuder, Nicholas R. Summerfield, Yuhao Yan
Affiliation: Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Northwestern Medicine Proton Center, Northwestern Medicine Chicago Proton Center, Leo Cancer Care
Abstract Preview: Purpose: Novel upright patient positioners coupled with diagnostic-quality vertical CT at treatment isocenter introduce a significant opportunity for improved image-guided particle therapy. Treating p...
Authors: Peter Balogh, Wesley E. Bolch, Mir Md Nasim Hossain, Nien-Wen Hu, Walter Murfee, Wyatt Smither, Julia D. Withrow
Affiliation: New Jersey Institute of Technology, University of Florida
Abstract Preview: Purpose: To develop 3D computational, tissue-representative models incorporating physiologically relevant microvascular network patterns for calculating local alpha particle and electron dosimetry eff...
Authors: Zahra Ahmadi Ganjeh, Stefan Both, Peter Dendooven, Jeffrey Free, Brian Zapien Campos
Affiliation: Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Particle Therapy Research Center (PARTREC), Department of Radiation Oncology, University Medical Center Groningen, University of Groningen
Abstract Preview: Purpose: Positron emission tomography (PET) has been investigated for range monitoring in intensity-modulated proton therapy (IMPT), but real-time feedback been limited due to the focus on long-lived ...
Authors: Scott James Bright, Vered Domankevich-Bachar, Mandira Manandhar, Poliana Marinello, Yogesh Rai, Marco Freitas Reis, Alexandre Rubinstein, Gabriel O. Sawakuchi, Ronen Segal, Walison Augusto Silva Brito, Mark Wasley, Amy Wu
Affiliation: MD Anderson Cancer Center, Alpha Tau Medical Ltd, Alpha Tau Medical LTD, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Immunologically cold breast cancers are aggressive and difficult to treat due to their lack of immune cell infiltration. The combination of high-LET radiation with DNA repair inhibitors offer...
Authors: Brian Burger, Carri K. Glide-Hurst, John W. Hayes, Carson Hoffman, Minglei Kang, Jessica R. Miller, Jordan M. Slagowski, Yuhao Yan
Affiliation: Department of Human Oncology, University of Wisconsin-Madison, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Leo Cancer Care
Abstract Preview: Purpose: The combination of upright CT and patient positioner for particle therapy present tremendous potential for high precision IGRT and online adaptive radiation therapy (ART), where reliable CT p...
Authors: Serdar Charyyev, Cynthia Fu-Yu Chuang, Veng Jean Heng, Lianli Liu, Lei Xing, Yong Yang
Affiliation: Department of Radiation Oncology, Stanford University
Abstract Preview: Purpose: To replace large finite-size photon phase space files with a compact neural network capable of generating an infinite number of particles.
Methods: Three separate models were developed to ...
Authors: Alan Rui Li, Qihui Lyu, Dan Ruan, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
The Sparse Primary Sampling (SPS) grid was shown in a previous computational study to improve image quality by correcting scatter-induced effects and artifacts in Cone-beam Computed Tomogr...
Authors: Shengwen Deng, Sven L. Gallo, Robert S. Jones, David W. Jordan, Arashdeep Kaur, Aishwarya M. Kulkarni, Quibai Li, William R.M. Pedersen
Affiliation: Department of Radiology, University Hospitals Cleveland Medical Center; School of Medicine, Case Western Reserve University, Department of Radiology, Radiation Safety, University Hospitals Cleveland Medical Center, Department of Radiology, Radiation Safety, University Hospitals Cleveland Medical Center; School of Medicine, Case Western Reserve University; Department of Radiology, Louis Stokes Cleveland VA Medical Center
Abstract Preview: Purpose:
Y-90 (Yttrium) SIRT radioembolization takes advantage of delivering localized radiation to the liver. Pre-treatment dosimetry is highly dependent on accurate MAA mapping, which may have an...
Authors: Brett Bocian, Patrick James Jensen, Luis Augusto Perles, Christopher J. Tien
Affiliation: Yale University School of Medicine, University of Miami, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center
Abstract Preview: Purpose: Guidelines for dose prescriptions in endometrial cancer are based upon depth from the cylinder, traditionally 5 mm or 0 mm (i.e., surface). There are no current single-channel vaginal cylinde...
Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Adam Leon Kesner, Cameron B. Kofler, Juan Camilo Ocampo Ramos, Yitian Wang, Stefan Wehmeier
Affiliation: University of Chicago, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson
Abstract Preview: Purpose: To develop a slice-specific computed tomography (CT) organ dose library using Monte Carlo radiation transport simulations on a newly created set of newborn, infant, and toddler computational ...
Authors: Seung Yeon Kim, Grant A. McAuley, Ju A Park, Jerry D Slater
Affiliation: Loma Linda University
Abstract Preview: Purpose: The production of proton minibeams in standard PBS nozzles is challenging due to the effects of finite source beam divergence and multiple Coulomb scattering. Herein we investigate the use of...
Authors: Boon-Keng Kevin Teo
Affiliation: University of Pennsylvania
Abstract Preview: N/A...
Authors: Xinyi Fu, Dan Ruan, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California, San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Digitally reconstructed radiographs (DRRs) are easy to generate and widely used to establish research protocols in pulmonary diagnosis and image-guided radiotherapy tasks. A question remai...
Authors: Chase Cochran, Damodar Pokhrel, William St Clair
Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine
Abstract Preview: Purpose: Currently, intraocular disease is primarily treated via COMS-plaques brachytherapy. Various stereotactic approaches via photons/proton beam have also been implemented (CyberKnife/GammaKnife/p...
Authors: Adedamola Adeniyi, Bryan Bednarz, Malick Bio Idrissou, Reinier Hernandez, Ohyun Kwon, Brian W. Miller, Zachary S Morris, Maya Takashima, Jamey Weichert
Affiliation: Departments of Radiation Oncology and Medical Imaging, University of Arizona, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Radiology, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin–Madison
Abstract Preview: Purpose: As radiopharmaceutical therapy (RPT) becomes more prevalent in clinical applications, understanding dose-response relationships in the tumor microenvironment (TME) and normal tissues is essen...
Authors: Jung Han Nam, Wonmo Sung
Affiliation: Department of Biomedical Engineering and Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Department of Biomedical Engineering and Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract Preview: Purpose: This study aims to develop a whole-body blood flow framework based on the ICRP 145 standard vascular phantom to simulate the spatiotemporal trajectories of blood cells in the human vasculatur...
Authors: Thomas R. Bortfeld, Prof. Elisabetta De Bernardi, Tianxue Du, Beatrice Foglia, Chiara Gianoli, Takamitsu Masuda, Katia Parodi, Marco Pinto, Boon-Keng Kevin Teo, Yunhe Xie
Affiliation: Department Of Radiation Oncology, Massachusetts General Hospital (MGH), School of Medicine and Surgery, University of Milano-Bicocca, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, National Institutes for Quantum Science and Technology (QST), University of Pennsylvania, Department of Experimental Physics - Medical Physics, Ludwig-Maximilians-Universität (LMU) München
Abstract Preview: Purpose: The full potential offered by protons in clinical practice is limited by range uncertainties. One possibility for monitoring is through secondary prompt gammas (PG). PG emission along the pen...
Authors: Kazi Towmim Afrin, Imad M. Ali, Jordan West
Affiliation: University of Oklahoma Health Sciences Center, University of Oklahoma
Abstract Preview: Purpose: To evaluate quantitatively the dosimetric uncertainties associated with dose calculation and measurement of small photon fields used in stereotactic photon therapy.
Methods: The output fac...
Authors: Yuzhen Ding, Hongying Feng, Jason Michael Holmes, Baoxin Li, Wei Liu, Daniel Ma, Lisa McGee, Samir H. Patel, Jean Claude M. Rwigema, Sujay A. Vora
Affiliation: Arizona State University, Department of Radiation Oncology, Mayo Clinic, Mayo Clinic Arizona, Mayo Clinic
Abstract Preview: Purpose:
Intensity-modulated proton therapy (IMPT) is a preferred treatment modality for head and neck (H&N) cancer patients, offering precise tumor targeting while sparing surrounding organs at ri...
Authors: Chieh-Ya Chiu, Shen-Hao Li, Hsin-Hon Lin, Shu-Wei Wu
Affiliation: Department of Medical Imaging and Radiological Sciences, Chang Gung University, Proton and Radiation Therapy Center, Chang Gung Memorial Hospital Linkou
Abstract Preview: Purpose: Monte Carlo simulation enables precise calculation of dose distribution in proton therapy through tracing the radiation particles with patient tissues. However, achieving clinical-level preci...
Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal, Chris C. Wang
Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology
Abstract Preview: Purpose: Radiobiological simulation via TOPAS-nBio requires significant computational resources and time to provide meaningful results. This study aims to decrease simulation time and computational re...
Authors: John Ford, Yu Fujiwara, Isao Murata, Zavier Ndum Ndum
Affiliation: Osaka University, Texas A&M University
Abstract Preview: Purpose: This study investigates how particle energy affects radiation quality and biological effectiveness with the inclusion of medical implants. Our research group used microdosimetric analysis to ...
Authors: Michael Butkus, Camilo M. Correa Alfonso, Olga M. Dona Lemus, James Arthur Perez-Sanchez
Affiliation: University of Miami
Abstract Preview: Purpose: Accurate skin dose calculation is essential for treating superficial lesions such as those of the breast, chest wall, and scalp. Clinical treatment planning systems often rely on approximatio...
Authors: David Alcorta, Lindsay Bolino, Olivia Canter, Seifallah Emam, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, David Loiselle, Mark Oldham, Victoria J. P. Radosova
Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke Univerity, Department of Radiation Oncology, Duke University Medical Center
Abstract Preview: Purpose: To simulate how Cherenkov light (CL) produced during radiation therapy can activate targeted photodynamic molecules. To experimentally determine dose and concentration thresholds for biologic...
Authors: Ramin Abolfath, Alejandro Bertolet, Kofi M. Deh, Rao Khan, Vanessa Sanders, Daniel Suarez-Garcia
Affiliation: Massachusetts General Hospital and Harvard Medical School, University of Sevilla, Brookhaven National Laboratory, Howard University
Abstract Preview: Purpose: To compare the efficacy of 225Ac to 90Y for local cancer therapy by quantifying DNA damage using Monte Carlo simulations.
Methods: The TOPAS n-Bio toolkit was used to simulate the irradiat...
Authors: Julie Colnot, Eric Deutsch, Christelle Huet, Danahé LeBlanc, Pauline Maury, Charlotte Robert, Imane Saïd Mansour, Cathyanne Schott, Francois Therriault-Proulx
Affiliation: INSERM U1030, Gustave Roussy, University Paris-Saclay, LDRI, IRSN, Medscint, THERYQ / INSERM U1030, Gustave Roussy, University Paris-Saclay, Université Paris-Saclay, Gustave Roussy, Inserm U1030, Radiothérapie Moléculaire et Innovation Thérapeutique
Abstract Preview: Purpose: FLASH radiotherapy, using ultra-high dose rates (UHDR, >100 Gy/s), spares healthy tissues while maintaining tumor control compared to conventional radiotherapy (CONV). However, UHDR dosimetry...
Authors: Lawrence F. Bronk, Fada Guan, Xun Jia, Youfang Lai, Miao Qi
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: DNA double-strand breaks (DSBs) are widely regarded as critical indicators of cellular response to ionizing radiation. This study aims to establish a direct, unbiased and universal correlatio...
Authors: Denis Bergeron, Larry A. DeWerd, Sean Jollota, Peyton Alexandra Lalain, Likhitha Polepalli
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, National Institute of Standards and Technology
Abstract Preview: Purpose: 90Y is a challenging radionuclide to measure because it is a pure beta-emitter and is typically quantified using a radionuclide calibrator. These devices, such as the Capintec model used in t...
Authors: Ciprian N. Ionita, Parisa Naghdi, Ahmad Rahmatpour
Affiliation: University at Buffalo, SUNY: University at Buffalo
Abstract Preview: Purpose: Quantitative angiography (QA) evaluates neurovascular hemodynamics, but is affected by X-ray parameters, vessel foreshortening, and imaging chain factors like detector efficiency, pixel size,...
Authors: Niels Bassler, Jonathan Bortfeldt, Francesco Evangelista, Giulio Lovatti, Jasper Nijkamp, Rasmus Nilsson, Munetaka Nitta, Katia Parodi, Marco Pinto, Per R. Poulsen, Brita Singers Sørensen, Peter Thirolf, Erik Traneus, Taiga Yamaya
Affiliation: RaySearch Laboratories AB, National Institutes for Quantum Science and Technology, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital
Abstract Preview: Purpose: Within the SIRMIO project (Small Animal Proton Irradiator for Research in Molecular Image-Guided Radiation Oncology), we aimed to perform the first in vivo proton beam treatment with a dedica...
Authors: Niels Bassler, Jonathan Bortfeldt, Davide Boscaini, Francesco Evangelista, Guyue Hu, Ze Huang, Margarita Kozak, Julie Lascaud, Giulio Lovatti, Eero Lönnqvist, Jasper Nijkamp, Munetaka Nitta, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Babak Sharifi, Brita Singers Sørensen, Peter Thirolf
Affiliation: Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital
Abstract Preview: Purpose: To perform the first in vivo application of a novel small animal radiation research platform combining on-board image-guidance with multi-field intensity modulated spot scanning delivery [1] ...
Authors: Niels Bassler, Jonathan Bortfeldt, Carlos Granja, Guyue Hu, Margarita Kozak, Julie Lascaud, Kirsten Lauber, Grigory Liubchenko, Jasper Nijkamp, Cristina Oancea, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Brita Singers Sørensen, Matthias Würl
Affiliation: Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital, Advacam
Abstract Preview: Purpose: To apply in-vivo proton radiography (pRad) to aid image registration and treatment plan refinement for a novel precision image-guided small animal proton irradiation platform.
Methods:...
Authors: Dirk A Bartkoski, Michael Kleckner, Dongyeon Lee, Reza Reiazi, Mohammad Reza Salehpour
Affiliation: The University of Texas MD Anderson Cancer Center, Convergent-RnR
Abstract Preview: Purpose:
To develop and validate G4BraggReflection, a novel physics process within Geant4, designed to incorporate diffraction properties resulting in Bragg reflection into Monte Carlo simulations....
Authors: Hamid Abdollahi Nasehabad, Mehrangiz Amiri, Mohammad Reza Deevband, Faraz Kalantari, Milad Peer-Firozjaei, Ali Shabestani Monfared, Ehsan Tajikmansoury
Affiliation: Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Department of Radiology, University of British Columbia, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, 1. Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Abstract Preview: Purpose:
Targeted radionuclide therapy (TRNT) with 213Bi- labeled radiopharmaceuticals is a promising approach in targeted alpha and beta therapy for cancer. This study aims to assess double-strand...
Authors: Michael Dohopolski, Jiaqi Liu, Hao Peng, Robert Timmerman, Zabi Wardak, Haozhao Zhang
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose:
This study introduces a gradient-based radiomics framework to enhance outcome prediction in Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR) for brain metastases...
Authors: Ulrike Dydak, Chia-Tien Hsu, Chang Geun Lee, Cora Mizimakoski, Humberto Monsivais, Jae Hong Park
Affiliation: Purdue University
Abstract Preview: Purpose: Overexposure to manganese (Mn) from inhaling welding fumes can lead to cognitive and motor deficits. We developed a whole-brain Mn-mapping approach to detect subtle but significant increases ...
Authors: Caroline Esposito, Keith T Griffin, Jae Won Jung, Choonik Lee, Choonsik Lee, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock
Affiliation: East Carolina University, University of Michigan, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: The National Cancer Institute’s Pediatric Proton and Photon Therapy Comparison Cohort aims to collect and analyze data from cancer centers across the United States and Canada to quantify diff...
Authors: Jason Chiang, Magnus Dahlbom, Veronica Hankil, Xinyi Li, Catherine (Caffi) Meyer, Kyung Hyun Sung
Affiliation: UCLA, University of California, Los Angeles
Abstract Preview: Purpose:
Yttrium-90 (90Y) radioembolization is a well-established therapy for large or multifocal liver tumors. Accurate dosimetry is critical but remains challenging, as low particle density risks...
Authors: Daylin Barroso, Chris Beekman, Wesley E. Bolch, Natalia Estefania Carrasco-Rojas, Robert Joseph Dawson, Walter Murfee, Harald Paganetti, Andrew Robert Sforza, Julia D. Withrow
Affiliation: Massachusetts General Hospital - Harvard Medical School, Massachusetts General Hospital, University of Florida
Abstract Preview: Purpose: To develop methods for quantifying the interaction of radiation with blood in the mouse whole body (MOBY) phantom for dosimetric applications. The most important of these are modeling the dis...
Authors: Konstantinos Chatzipapas, George C. Kagadis, Panagiotis Konstas, Dimitris N. Mihailidis, Dimitris Visvikis
Affiliation: LaTIM, INSERM UMR1101, University of Pennsylvania, LaTIM, INSERM, University of Brest, University of Patras
Abstract Preview: Purpose: This study investigates the temporal evolution of radiolytic species (H3O+, OH•, OH-) in water under electron and proton irradiation using the mesoscopic chemistry model that allows longer te...
Authors: Gregory A Azzam, Michael Butkus, Nesrin Dogan, Robert Kaderka, Nhan Vu, Yihang Xu
Affiliation: University of Miami, Department of Radiation Oncology, University of Miami, University of Miami Sylvester Comprehensive Cancer Center, University of Miami, Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose: Knowledge-based planning (KBP) has demonstrated potential for improving planning quality and efficiency. Adoption of KBP in particle therapy has been slow due to limited number of plans to tr...
Authors: Silvia Calusi, Lucia Cavigli, Alberto Dalla Mora, Laura Di Sieno, Giacomo Insero, Riccardo Lisci, Livia Marrazzo, Cosimo Nardi, Stefania Pallotta, Andrea Profili, Fulvio Ratto, Giovanni Romano, Michaela Servi, Immacolata Vanore, Yary Volpe
Affiliation: Italian National Research Council IFAC-CNR, Institute of Applied Physics, Department of Physics, Politecnico di Milano, Department of Agricultural Food and Forestry System, University of Florence, Medical Physics Unit, Azienda Ospedaliero-Universitaria Careggi, Department of Industrial Engineering, University of Florence, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence
Abstract Preview: Purpose: To develop a multi-purpose lung phantom prototype to replicate respiratory dynamics and morphological features observed in clinical radiological (CT and MR) imaging of lung parenchyma.
Met...
Authors: John P. Aris, Wesley E. Bolch, Chansoo Choi, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Abdul-Vehab Dozic, Amy M. Geyer, Harald Paganetti, Shreya P. Pathak, Julia D. Withrow
Affiliation: St. Luke's Health System, Massachusetts General Hospital, University of Florida
Abstract Preview: Purpose: The goal of this study was to enhance the accuracy of renal dosimetry in radiopharmaceutical therapy (RPT) by developing a more detailed and precise kidney model. In RPT, accurate dose estima...
Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang
Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...
Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang
Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center
Abstract Preview: Purpose: Using mixed fractionation schemes is a common technique in treating CNS lesions. This article describes an innovative plan-and-split approach for more efficient planning on the ZAP-X and thus...
Authors: Panagiotis Iliopoulos, Marios Myronakis, Kyriaki Theodorou
Affiliation: Medical Physics Department, Medical School, University of Thessaly
Abstract Preview: Purpose: To estimate individualized absorbed dose at Organs at Risk (OARs) from kV Cone Beam CT (CBCT) imaging in the pelvic area, prior radiotherapy, and assess excess risk for secondary malignancies...
Authors: Alexei V. Trofimov
Affiliation: Massachusetts General Hospital
Abstract Preview: N/A...
Authors: Richard A. Amos
Affiliation: University College London
Abstract Preview: N/A...
Authors: Wesley E. Bolch, Chansoo Choi, Robert Joseph Dawson, Michael Lassmann, Maikol Salas-Ramirez, Bangho Shin, Johannes Tran-Gia, Yitian Wang
Affiliation: Department of Nuclear Medicine, University Hospital Würzburg, University of Florida
Abstract Preview: Purpose: Conduct a parameterized library of mesh-type skeletal models across the lumbar vertebrae. In radiopharmaceutical dosimetry, the hematopoietic active bone marrow is typically a dose-limiting n...
Authors: Qijie Huang, Gourav Jhanwar, Saad Nadeem, Vicki Trier Taasti, Mojtaba Tefagh, Seppo Tuomaala, Masoud Zarepisheh
Affiliation: Varian Medical Systems Inc, Department of Clinical Medicine - Danish Center for Particle Therapy, Aarhus University Hospital, Memorial Sloan Kettering Cancer Center, The University of Edinburgh
Abstract Preview: Purpose:
We have developed PortPy (Planning and Optimization for Radiation Therapy in Python), a first-of-its-kind open-source package designed to accelerate research and development in radiotherap...
Authors: Julien Bancheri, Chau Giang Bui, David G Cooke, Christopher M Lund, Morgan J Maher, Jan P. Seuntjens, Jason Z Yuan
Affiliation: Princess Margaret Cancer Centre & University of Toronto, Medical Biophysics, University of Toronto, University of Toronto, Medical Physics Unit, McGill University, Department of Physics, McGill University
Abstract Preview: Purpose: The dielectric wall accelerator (DWA) offers a low-cost solution for proton therapy, using non-resonant waveguides to accelerate particles. Radial waveguides (RWGs), consisting of a dielectri...
Authors: Go Akamatsu, Han Gyu Kang, Chie Seki, Hitomi Sudo, Hideaki Tashima, Chie Toramatsu, Hidekatsu Wakizaka, Iwao Yamaya, Taiga Yamaya
Affiliation: National Institutes for Quantum Science and Technology
Abstract Preview: Purpose:
Tumor oxygen status, which provides important information to optimize particle therapy, may constantly change during a treatment period of several weeks. However, it is impractical to perf...
Authors: Ruiyan Du, He Huang, Mingzhu Li, Ying Li, Hongyu Lin, Wei Liu, Shihuan Qin, Yiming Ren, Hui Xu, Lian Zhang, Xiao Zhang, Zunhao Zhang
Affiliation: Department of Radiation Oncology, Mayo Clinic, Medical AI Lab, The First Hospital of Hebei Medical University, Hebei Provincial Engineering Research Center for AI-Based Cancer Treatment Decision-Making, The First Hospital of Hebei Medical University, Department of Oncology, The First Hospital of Hebei Medical University
Abstract Preview: Purpose: Monte Carlo (MC) dose calculation is the gold standard in clinical CyberKnife radiation therapy (RT), considering its steep dose gradients and high-freedom non-coplanar beam angles, but extre...
Authors: Ye Zhang
Affiliation: Paul Scherrer Institut
Abstract Preview: N/A...
Authors: Yankui Chang, Shijun Li, Xi Pei, Ripeng Wang, Xuanhe Wang, X. George Xu, Qing Zhang, Jingfang Zhao
Affiliation: University of Science and Technology of China, Shanghai proton and heavy ion center, School of Nuclear Science and Technology, University of Science and Technology of China, Anhui Wisdom Technology Co., Ltd.
Abstract Preview: Purpose:
This paper describes disruptive methods using both GPU-based MC simulation and deep-learning (DL)-based MC denoising algorithms, as well as clinical tests involving more than 560 patient p...
Authors: Angela Gearhardt, Stephen F. Kry, Christopher Ryan Peeler, Julianne M. Pollard-Larkin
Affiliation: The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: A growing number of radiation therapy (RT) patients have cardiovascular implantable electronic devices (CIEDs). Patients with CIEDs must be carefully managed because the devices are susceptib...
Authors: Anahita Bakhtiari Moghaddam, Don F. DeJongh, Ethan DeJongh, Jennifer Hardt, Oliver Jäkel, Lukas Martin, Alexander Pryanichnikov, Joao Seco, Christina Stengl, Niklas Wahl
Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), ProtonVDA LLC, Department of Physics and Astronomy, Heidelberg University, Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT)
Abstract Preview: Purpose:
To evaluate the feasibility and performance of single-plane position tracking for proton and helium pencil beam radiography using a prototype imaging system, with the goal of providing a c...
Authors: Joana Antunes, Scott James Bright, David B. Flint, Mojtaba Hoseini-Ghahfarokhi, Mandira Manandhar, Poliana Marinello, Gabriel O. Sawakuchi, Tingshi Su
Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Laboratory of Instrumentation and Experimental Particle Physics; Faculty of Science of University of Lisbon, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, MD Anderson Cancer Center
Abstract Preview: Purpose: To study the accuracy of relative biological effectiveness (RBE) models to predict the RBE of a comprehensive panel of pancreatic cancer cell lines.
Methods: Clonogenic cell survival w...
Authors: Michael Dingfelder
Affiliation: East Carolina University
Abstract Preview: Purpose:
To study and accurately evaluate the influence of the Fermi Density effect on stopping powers and cross sections of charged particles in liquid water used in Monte Carlo radiation transpor...
Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Thongchai Masilela, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin
Affiliation: University of California San Francisco, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital
Abstract Preview: Purpose: To present the results of 15 years of developments of the TOPAS TOol for PArticle Simulation framework, and to highlight recent and new developments.
Methods: Fundamental understanding...
Authors: Lennart Volz
Affiliation: GSI Helmholtz Center for Heavy Ion Research GmbH
Abstract Preview: N/A...
Authors: Victoria Susan Ainsworth, Wilfred F. Ngwa, Erno Sajo
Affiliation: University of Massachusetts Lowell, Johns Hopkins University
Abstract Preview: Purpose: In nanoparticle-enhanced radiotherapy, the dose enhancement is function of the particle size. At therapeutic concentrations, the number density of nanoparticles gives rise to a high rate of i...
Authors: Eric S. Diffenderfer, Lei Dong, Alejandro Garcia, Wenbo Gu, Michele M. Kim, Alexander Lin, Kai Mei, Peter B. Noël, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: We present a novel 3D-printed range-modulating devices with spatially modulated density for FLASH particle therapy. By varying density distributions, spread-out Bragg peaks(SOBPs) can be gene...
Authors: Jiankui Yuan, Dandan Zheng, Tingliang Zhuang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, University of Rochester, Varian Medical Systems, Advanced Oncology Solutions
Abstract Preview: Purpose: In Monte Carlo (MC) radiation therapy dose calculations, latent variance exists when directly applying phase-space files (PSF) with a finite number of source particles, while the latter is pr...
Authors: Go Akamatsu, Hiroaki Ikawa, Yuma Iwao, Han Gyu Kang, Masashi Koto, Hideyuki Mizuno, Akram Mohammadi, Makoto Shinoto, Minoru Tajiri, Hideaki Tashima, Chie Toramatsu, Taiga Yamaya
Affiliation: National Institutes for Quantum Science and Technology
Abstract Preview: Purpose: In-beam positron emission tomography (PET), in which positron emitters produced through fragmentation reactions are visualized, is a practical method for range verification in particle therap...