Search Submissions πŸ”Ž

Results for "post sbrs": 53 found

A Comparison of Non-Adaptive Versus Online Adaptive Radiotherapy for Prostate Cancer Using FLOW-RT-- Fast, AI-Driven but Learning-Enabled, Online Adaptive Workflow for Radiotherapy

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Beatriz Guevara, Lauren E Henke, Angela Jia, Rojano Kashani, Kyle O'Carroll, Alex T. Price, Adithya Reddy, Atefeh Rezaei, Daniel E Spratt, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: To evaluate the effect of unedited AI-generated contours used for online adaptive radiotherapy (FLOW-ART) on the plan quality of prostate treatments as compared to non-adaptive (non-ART) proc...

A New Way to Assess Dynamic Response of Centrally Located Lung Cancer (CLLC) to SBRT and Conventional Radiation Therapy (CRT)

Authors: Nina Burbure, Tawfik Giaddui, Shidong Li, Curtis Miyamoto, Jeremy Price, Bin Wang

Affiliation: FCCC at Temple University Hospital, Dept. of Radiation Oncology, Fox Chase Cancer Center at Temple University Hospital

Abstract Preview: Purpose: Higher rates of local failures and toxicities challenged radiation therapy of centrally located lung cancer (CLLC). We assessed the treatment response by measuring the early changes of PET+ n...

A Novel Non-Measured and DVH-Based IMRT QA Framework with Machine Learning for Instant Classification of Susceptible Lung SBRT VMAT Plans

Authors: Chuan He, Anh H. Le, Iris Z. Wang

Affiliation: Roswell Park Comprehensive Cancer Center, Cedars-Sinai

Abstract Preview: Purpose: To develop a non-measured and DVH-based (NMDB) IMRT QA framework integrating machine learning (ML) to classify lung SBRT VMAT plans prone to delivery errors
Methods: 560 Eclipse AcurosXB l...

A Pilot Study to Implement a Definitive Breast SBRT Technique

Authors: Charmainne Cruje, Maria Dumol, Nawroz Fatima, Marisa Finlay, Kalaina Johnson, Raman Mohla, Jasleen Uppal

Affiliation: Trillium Health Partners, Carlo Fidani Regional Cancer Centre

Abstract Preview: Purpose: To evaluate the robustness of a breast SBRT protocol in achieving target coverage by utilizing online- and retrospectively-matched CBCT-to-CT images.
Methods: The first pilot patient was s...

Advancing Ionizing Radiation Acoustic Imaging: A Deep Learning Approach for Denoising and Quantitative Reconstruction

Authors: Kyle Cuneo, Issam M. El Naqa, Dale W. Litzenberg, Yiming Liu, Xueding Wang, Lise Wei, Wei Zhang, Jiaren Zou

Affiliation: University of Michigan, H. Lee Moffitt Cancer Center

Abstract Preview: Purpose: To quantitatively map 3D dose deposition during radiotherapy, empowering real-time adaptive radiation treatment.

Methods: The research features reconstructing dose deposition from acou...

Assessing an Improvement to Hyperarc SRS Planning: Comparing the Efficiency Index of Hyperarc Alone Vs Hyperarc + Surface Area Informed Optimization

Authors: Ivan L. Cordrey, Dharmin D. Desai, Ellis Lee Johnson

Affiliation: Cumberland Medical Center - Cancer Center, University of Kentucky, Varian Advanced Oncology Solutions

Abstract Preview: Purpose: HyperArc (HA) is known to produce a high quality SRS plan. Adding Surface Area Informed Optimization (SAIO) to HA has been shown to improve plan quality metrics R50% and the Conformality Inde...

Assessing the Impact of Intrafraction Shifts on Critical OAR Doses in a Standardized Spine SBRT Program

Authors: Daniel A. Alexander, Anish Butala, Anthony Austin Kassaee, Neil Malhotra, Ian Messing, Gabrielle W Peters, Ryan M. Scheuermann

Affiliation: Department of Radiation Oncology and Applied Sciences, University of Pennsylvania

Abstract Preview: Purpose: Stereotactic Body Radiation Therapy (SBRT) for spinal metastases uses CBCT-based localization and highly conformal treatment delivery to increase the biologically equivalent dose to the targe...

Auto-Segmentation Scripting to Generate Optimization Structures for Spine SBRT Planning

Authors: Jon Hansen

Affiliation: Washington University in St Louis

Abstract Preview: Purpose: Commercially available auto-segmentation software was utilized to generate institution-specific optimization structures for spine stereotactic body radiation therapy (SBRT). Implementation of...

Bayesian Mixture Modelling of Apparent Diffusion Coefficients from Whole-Body MRI Reveals Significant Changes in Metastatic Lesions Treated with Stereotactic Body Radiotherapy Compared to Untreated Controls

Authors: Giacomo Avesani, Matthew D Blackledge, Silvia Bottazzi, Alison Tree, Nina Tunariu

Affiliation: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Institute of Cancer Research, The Royal Marsden NHS Foundation Trust

Abstract Preview: Purpose: To evaluate changes in median apparent diffusion coefficient (ADC) within metastatic oligoprogressing lesions from prostate cancer treated with stereotactic body radiotherapy (SBRT) and compa...

Benefits on Respiratory Gating Delivery of Lung SBRT

Authors: Andrew Huang, Jonathan Huang, Andrew S Kennedy, Ellie Grace Kong, Ajay Zheng

Affiliation: New York Proton Center, Centennial Medical Center, Executive Medical Physics Associates, Sarah Cannon Cancer Institute, Belmont University

Abstract Preview: Purpose:
Lung stereotactic body radiotherapy (SBRT) is the standard of care for early-stage lung cancer. Respiratory phase gating can be applied to mitigate motion-induced effects. The purpose of t...

Biologically Guided Deep Learning for MRI-Based Brain Metastasis Outcome Prediction after Stereotactic Radiosurgery

Authors: Evan Calabrese, Hangjie Ji, Kyle J. Lafata, Casey Y. Lee, Eugene Vaios, Chunhao Wang, Lana Wang, Zhenyu Yang, Jingtong Zhao

Affiliation: Duke University, Department of Radiation Oncology, Duke University, Duke Kunshan University, North Carolina State University

Abstract Preview: Purpose: To develop a biologically guided deep learning (DL) model for predicting brain metastasis(BM) local control outcomes following stereotactic radiosurgery (SRS). By integrating pre-SRS MR image...

CBCT and Exactrac Dynamic Agreement for Patient Positioning during Spine SRS/SBRT Treatments

Authors: Martha J. Malin, Matthew Schelin

Affiliation: NYU Langone Health

Abstract Preview: Purpose: To evaluate the agreement between ExacTrac Dynamic (ETD) and CBCT-based positioning for spine SRS/SBRT treatments during initial patient setup and repositioning after intrafraction motion.

Clinical Feasibility of a Deep-Learning-Based Auto Contouring through Qualitative and Dosimetric Assessments

Authors: Sara Endo, Takeshi Fujisawa, Hidehiro Hojo, Masaki Nakamura, Hidenobu Tachibana

Affiliation: Department of Radiation Oncology, National Cancer Center Hospital East, Radiation Safety and Quality Assurance Division, National Cancer Center Hospital East

Abstract Preview: Purpose: To assess the clinical feasibility of deep learning (DL)-based automated contouring through qualitative and quantitative assessments.

Methods: Sixty cases were chosen, including 3 OARs...

Clinical Implementation of a Film Based Psqa System for SBRT on a 1.5T MR-Linac

Authors: Dylan Yamabe Breitkreutz, Lee Chin, Brige P. Chugh, Mark D'Souza, Brian M. Keller, Anthony Kim, Michelle K. Nielsen, Arjun Sahgal

Affiliation: Sunnybrook Health Sciences Centre

Abstract Preview: Purpose: The Elekta Unity MR-linac delivers highly conformal SBRT treatments using IMRT. These treatment plans require patient-specific quality assurance (PSQA) measurements to detect discrepancies be...

Comparison Study of Shift Frequency and Magnitude By Prostate Fiducial Tracking System: Triggered Image and Calypso

Authors: David J. Carlson, Yiu-Hsin Chang, Zhe (Jay) Chen, Hyosung Cho, Dae Yup Han, MinYoung Lee, Weili Zhong

Affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, Yonsei University

Abstract Preview: Purpose:
To compare the intra-fractional motion tracking sensitivity of prostate fiducial markers using triggered imaging and calypso tracking for prostate cancer cases.
Methods:
This study w...

Comprehensive Analysis of Plan Modulation in SRS/SBRT Plans: A Single Institution Study of 461 Cases

Authors: Yunfeng Cui, Will Giles, Xinyi Li, Ke Lu, Jennifer C. O'Daniel, Anna E. Rodrigues, Chunhao Wang, Lana Wang, Yibo Xie, Sua Yoo, Jingtong Zhao

Affiliation: Duke University, Duke University Medical Center

Abstract Preview: Purpose:
To establish quantitative measurement of plan modulation for SRS/SBRT treated with Volumetric Modulated Arc Therapy (VMAT) on C-arm LINACs.
Methods:
A total of 461 plans were analyze...

Decision Support for Adaptive Vs Non-Adaptive SBRT for Left-Sided Adrenal Tumors

Authors: Robbie Beckert, Austen N. Curcuru, Farnoush Forghani, Yi Huang, Geoffrey D. Hugo, Hyun Kim, Eric Laugeman, Luke Christian Marut, Thomas R. Mazur, Allen Mo, Emily Sigmund

Affiliation: Washington University in St. Louis School of Medicine, WashU Medicine, Washington University School of Medicine in St. Louis, Wash U Medicine, Washington University in St. Louis, Department of Radiation Oncology, Washington University School of Medicine in St. Louis

Abstract Preview: Purpose: Adaptive SBRT is resource intensive, requiring additional personnel for online planning, and should be reserved for cases where it is most beneficial. The purpose of this research is to creat...

Deep Learning-Based Ventricular Auto-Segmentation for Dosimetric Analysis in Intraventricular Tumor SRS

Authors: John Byun, Juan J Cardona, Steven D Chang, Cynthia Fu-Yu Chuang, Xuejun Gu, Yusuke Hori, Hao Jiang, Fred Lam, Lianli Liu, Weiguo Lu, David Park, Erqi Pollom, Elham Rahimy, Deyaaldeen Abu Reesh, Scott Soltys, Gregory Szalkowski, Lei Wang

Affiliation: Department of Radiation Oncology, Stanford University, Department of Neurosurgery, Stanford School of Medicine, Department of Neurosurgery, Stanford University, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose:
Intraventricular tumors pose significant challenges in neurosurgery due to their complex location. Therefore, brain SRS could be a better treatment option. At our institution, some patient...

Development and Clinical Validation of a Tissue Maximum Ratio (TMR)-Based Monitor Units Second Check Script for Dynamic Conformal-Based Hyperarc Brain Radiosurgery Plans Via Scatter Correction Factors

Authors: Jacob Gooslin, Ellis Lee Johnson, Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: HyperArc radiosurgery permits treatment of multiple brain lesions using a single-isocenter improving treatment planning efficiency and workflow. A key stereotactic planning aspect is an indep...

Development of a Novel 3D-Printed Heterogeneous Phantom for Liver SBRT Dose Verification in Hepatocellular Carcinoma (HCC) Treatment.

Authors: Dr. Sheaka Alobaidli, Anju K V, Dr. Chiranjib Konar, Sreejesh MS, Dr. Vijayaprabhu N, Dr. Deepti Sharma, Dr. Hanuman Prasad Yadav

Affiliation: Amity Institute of Applied Sciences, Kuwait Cancer Control Center, Institute of Liver and Biliary Sciences, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Amity institute of Applied Sciences, Amity University, Institute of Liver and Biliary Sciences(ILBS)

Abstract Preview: Purpose:
The accuracy of dose delivery in stereotactic body radiotherapy (SBRT) is critical for effectively treating hepatocellular carcinoma (HCC). This study aims to develop patient-specific 3D-p...

Developments of a Low-Cost Multi-Target Winston-Lutz Phantom and Software for SRS Linac Machines

Authors: Nellie Brovold, Wenbo Gu, Huan Amanda Liu, Lin Ma

Affiliation: University of Pennsylvania, Mayo Clinic

Abstract Preview: Purpose: To develop a low-cost comprehensive QA phantom and software for single-iso multi-target SRS Linac machines. This phantom can perform 1) Winston-Lutz QA test for on-axis and off-axis targets, ...

Direct-to-Unit Dose Calculations for Stereotactic Radiosurgery on a C-Arm Linac with Modern on-Board Imaging Solutions

Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Haley K Perlow, Alex T. Price, Atefeh Rezaei, Prashant Vempati, Runyon C. Woods

Affiliation: University Hospitals Seidman Cancer Center

Abstract Preview: Purpose: The HyperSight imaging feature on C-arm linacs(HS-CBCT) offers increased CT number accuracy over conventional on-board imaging. The C-arm geometry allows for noncoplanar treatments common to ...

Dosimetric Comparison of 6X and 10X Flattening Filter-Free Photon Beams on a Truebeam Linac Using the Eclipse TPS

Authors: Carlos E. Cardenas, Udbhav S. Ram, Marcin Wierzbicki

Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham, Juravinski Cancer Centre

Abstract Preview: Purpose:
This study aims to systematically evaluate the dosimetric properties and delivery efficiency of 6X-FFF and 10X-FFF beams for lung SBRT on the Varian TrueBeam STx using the Eclipse TPS 16.1...

Early GU Toxicity Prediction in Prostate SBRT Using Delivered Dosimetry Via Long Short-Term Memory Model

Authors: Amar Kishan, Jun Lian, Yunkui Pang, Jonathan Pham, X. Sharon Qi, Michael Steinberg, Luca F Valle, Pew-Thian Yap

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of North Carolina at Chapel Hill

Abstract Preview: Purpose: Stereotactic body radiotherapy (SBRT) is a highly effective treatment for prostate cancer, yet predicting genitourinary (GU) toxicity has primarily relied on planned dosimetry. This study inv...

Enhanced Prediction of Iroc Stereotactic Radiosurgery Phantom Audit Results with Treatment Parameters, Complexity Metrics, DVH, and Dosiomics Using Machine Learning

Authors: Lian Duan, Stephen F. Kry, Hunter S. Mehrens, Christine Peterson, Paige A. Taylor

Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center

Abstract Preview: Purpose: To develop predictive models for IROC SRS head phantom audits and to identify important factors influencing institutional performance.
Methods: The IROC SRS head phantom includes two TLDs ...

Enhancing Urethral Visualization for Prostate SBRT Using Post-Void T2-Weighted Imaging on a Low-Field 0.35T MR-Linac System

Authors: Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Tino Romaguera, Nishan Shrestha, Somol Sunny

Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: Accurate delineation of the urethra is critical for optimizing tumor control and minimizing urethral toxicity in prostate stereotactic body radiation therapy (SBRT). The purpose of this study...

Evaluation of MRI Distortion across a Multi-Site Health System and the Importance of MRI Distortion QA in Stereotactic Radiosurgery (SRS)

Authors: Emel Calugaru, Jenghwa Chang, Sean T Grace, Nicholas Harvey, Jessica Jung, Ching-Ling Teng

Affiliation: Northwell, Hofstra University, Hofstra University Medical Physics Program

Abstract Preview: Purpose: To evaluate the consistency of MRI distortion corrections across Northwell Health system and evaluate the necessity and importance of distortion QA for MRIs used for stereotactic radiosurgery...

Evaluation of Potential Dosimetric Risks from Intra-Fractional Motion in Single-Isocenter Stereotactic Radiosurgery

Authors: Brian D. Casto, Mathew Y Kang, Lichung Ku, Samuel J Wang, Joseph B. Ying, Walker Ray Zimmerman

Affiliation: Salem Health Cancer Center, Salem Health

Abstract Preview: Purpose: Varian HyperArc is an advanced radiotherapy module designed to efficiently deliver high-quality multi-target stereotactic radiosurgery (SRS) treatment plans on Varian linacs. However, the int...

Feasibility of Using a Dynamic-Platform with High-Resolution Patient-Specific QA Device for Periodic and Patient-Specific-QA in Respiratory-Gated Radiotherapy Lung SBRT Treatment

Authors: Tae Kyu Lee

Affiliation: Allina Health

Abstract Preview: Purpose: To assess the feasibility of a dynamic-platform integrated with high-resolution patient-specific-quality-assurance (PSQ device for periodic quality assurance (PQA) and PSQA in respiratory-gat...

Functional Liver Image Guided Radiation Planning Using MRI with a Contrast Agent

Authors: Kenneth L. Homann, Natalie A Lockney, Hong Zhang

Affiliation: Department of Radiation Oncology, Vanderbilt University Medical Center, Vanderbilt University Medical Center

Abstract Preview: Purpose: The aim of this study is to develop a treatment planning methodology utilizing liver functional imaging via contrast-enhanced Magnetic Resonance Imaging (MRI) in patients undergoing stereotac...

Image Guidance for Mitigating the Impact of Table Walkout on Delivered Dose in Non-Coplanar Stereotactic Radiotherapy

Authors: William E Burrell, Philip F. Durham, Anne N Hubbard, Yohan Akeakamai Walter, Hsinshun Terry Wu

Affiliation: Willis Knighton Cancer Center

Abstract Preview: Purpose: Linear accelerator (LINAC)-based single-isocenter, multi-target (SIMT) treatment has streamlined the stereotactic radiosurgery (SRS) workflow. However, off-isocenter treatment carries multipl...

Impact of IMRT Beam Scatter and Electronic Noise on Real-Time Kv and Fluoroscopy Image Quality

Authors: Wei Luo, Cameron Thayer-Freeman, Yifeng Zhao

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky

Abstract Preview: Purpose: Real-time Kilovoltage (kV) imaging has emerged as a powerful clinical aid, providing high-precision localization of moving targets during treatment. However, the Megavoltage (MV) treatment be...

Improving Post-SRS Brain Metastasis Radionecrosis Diagnosis Accuracy Via Deep Feature Space Analysis

Authors: Evan Calabrese, Scott R. Floyd, Kyle J. Lafata, Zachary J. Reitman, Eugene Vaios, Chunhao Wang, Lana Wang, Deshan Yang, Zhenyu Yang, Jingtong Zhao

Affiliation: Duke University, Department of Radiation Oncology, Duke University, Duke Kunshan University

Abstract Preview: Purpose:
This study proposes a novel neural ordinary differential equation (NODE) framework to distinguish post-SRS radionecrosis from recurrence in brain metastases (BMs). By integrating imaging f...

Key Tumor Volume Zones for Advancing the Radiomics-Based Distant Recurrence Prediction

Authors: Ryan Alden, Tithi Biswas, Kaushik Halder, Felix Maria-Joseph, Michael Mix, Rihan Podder, Tarun Kanti Podder

Affiliation: SUNY Upstate Medical University, IIT-Roorkee, University of Florida

Abstract Preview: Purpose: Radiomics feature-based model for predicting distant recurrence can potentially provide critical insight for clinical decision-making and assistance in treatment strategies. This study focuse...

Knowledge-Based Deep Residual U-Net for Synthetic CT Generation Using a Single MR Volume for Frameless Radiosurgery

Authors: Justus Adamson, John Ginn, Yongbok Kim, Ke Lu, Trey Mullikin, Xiwen Shu, Chunhao Wang, Zhenyu Yang, Jingtong Zhao

Affiliation: Duke University, Duke Kunshan University

Abstract Preview: Purpose:
To develop a knowledge-based deep model for synthetic CT (sCT) generation from a single MR volume in frameless radiosurgery (SRS), eliminating the need for CT simulation prior to the SRS d...

MR-Based Functional Liver Imaging and Dosimetry to Predict Albi Change Post-SBRT

Authors: Madhava Aryal, James M. Balter, Yue Cao, Daniel T Chang, Kyle Cuneo, Joseph R. Evans, Theodore Lawrence, John Rice, Randall K. Ten Haken, Lise Wei

Affiliation: University of Michigan, Department of Radiation Oncology University of Michigan

Abstract Preview: Purpose: This study aims to identify predictors of global liver function change measured by albumin-bilirubin (ALBI) score following stereotactic body radiation therapy (SBRT) in hepatocellular carcin...

Minimizing Positioning Errors in Intracranial SRS: The Role of Verification Imaging after 6-Dof Corrections

Authors: Anthony J. Doemer, Yimei Huang, Benjamin Movsas, Ellen Park, Mira Shah, Salim Siddiqui, Karen C. Snyder, Kundan S Thind, Bo Zhao

Affiliation: Henry Ford Health

Abstract Preview: Purpose: The 6 degrees-of-freedom (6-DoF) robotic couch is considered essential for linac-based stereotactic radiosurgery (SRS), particularly for irregularly shaped targets adjacent to critical organs...

Multi-Path Deep Learning Model for Predicting Post-Radiotherapy Functional Liver Imaging in Patients with Hepatocellular Carcinoma

Authors: Smith Apisarnthanarax, Stephen R. Bowen, Sunan Cui, Jie Fu, Clemens Grassberger, Yulun He, Yejin Kim, Matthew J. Nyflot, Sharon Pai

Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Washington, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Department of Physics, University of Washington, University of Washington and Fred Hutchinson Cancer Center

Abstract Preview: Purpose: 99mTc-sulfur colloid SPECT imaging enables quantitative assessment of voxel-wise liver function in patients with hepatocellular carcinoma (HCC). Accurately predicting post-radiotherapy (RT) l...

NTCP Modeling and Dose-Volume Correlations for Rectal Symptoms Following Prostate Cyberknife SBRT.

Authors: Nicholas Joseph Casteloes, Brian T Collins, Sean P Collins, Shiva K. Das, Panayiotis Mavroidis, Michael Repka, Simeng Suy

Affiliation: University of South Florida, University of North Carolina

Abstract Preview: Purpose: To correlate four rectal symptoms with the dose to rectum in patients, who received SBRT with Cyberknife for prostate cancer. Also, to fit those dosimetric and outcome data by using a normal ...

NTCP Modeling of Dose to Bladder and Urethra with Urinary Symptoms Following Prostate Cyberknife SBRT.

Authors: Nicholas Joseph Casteloes, Brian T Collins, Sean P Collins, Shiva K. Das, Panayiotis Mavroidis, Michael Repka, Simeng Suy

Affiliation: University of South Florida, University of North Carolina

Abstract Preview: Purpose: To correlate two urinary symptoms with dose to bladder and urethra in patients who received SBRT with Cyberknife. Also, to use a normal tissue complication (NTCP) model to fit the dosimetric ...

Next Generation Nanoparticles for Fractionated MRI-Guided Radiation Therapy

Authors: Stephanie Bennett, Ross I. Berbeco, Guillaume Bort, Needa Brown, Lena Carmes, Sandrine Dufort, Michael John Lavelle, Geraldine Le Duc, Francois Lux, Toby Morris, Zeinaf Muradova, Andrea Protti, Olivier Tillement

Affiliation: University de Lyon, NH TherAGuIX, University of Massachsetts Lowell and Dana-Farber Cancer Institute Boston, Department of Radiation & Cellular Oncology, University of Chicago, University of Central Florida, Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, NH TherAguix, Universite de Lyon, Brigham and Women's Hospital, Dana-Farber Cancer Institute

Abstract Preview: Purpose: AGuIX is a theranostic Gd-based nanoparticle currently under phase-2 clinical testing where patients receive 2-3 doses at 1-week intervals prior to imaging and irradiation. AGuIX-Bi is a new ...

Off- Axis Winston Lutz on C-Arm Linac Using in-House Phantom

Authors: Colton Baley, Bhuvaneswari Narayanan, Niko Papanikolaou, Daniel L. Saenz

Affiliation: UT Health San Antonio, Texas Oncology, University of Texas HSC San Antonio

Abstract Preview: Purpose: To evaluate the accuracy of off-axis winston lutz (WLT) for linac based stereotactic radiosurgery (SRS) treatments using in-house phantom.

Methods: Traditional WLT that uses cone and s...

Presenting a Novel Treatment Scheme for Debulking Unresectable Large Tumors: Feasibility, Safety and Patient Reported Early Clinical Outcomes of SBRT Immediately Post-Spatially Fractionated Radiotherapy Delivery

Authors: James Knight II, Joshua Misa, Damodar Pokhrel, William St Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Highly-heterogenous sieve-like dose distribution via SFRT to large/bulky tumors (β‰₯6 cm) could enhance tumor cell-death via both direct/indirect cell-kill mechanisms. Adding highly-conformal S...

Proactive Quality Assurance for Adaptive Radiotherapy: Real-Time Mlc Verification with Myqa SRS

Authors: James L. Giltz, Michael J. Merrick

Affiliation: Alyzen Medical Physics, University of Kentucky

Abstract Preview: Purpose: To evaluate the capability of MyQA SRS in performing high-resolution machine QA to verify multileaf collimator (MLC) behavior and integrity for adaptive radiotherapy (ART). This study demonst...

Prostate SBRT Motion Study and PTV Margin Evaluation with Exactrac Fiducial Tracking

Authors: Ahmad K. Al-Basheer, Andrew Clarke Grice, Kelly E. Hosier, Mark Logsdon, Evan A. Silverstein, Chris Tunnicliff, Chuan Wu

Affiliation: Sutter Medical Foundation, Sutter Health

Abstract Preview: Purpose: For Prostate SBRT Boost treatments, determine whether a uniform 2mm CTV to PTV margin is sufficient to give 95% dose coverage to the CTV in 90% of patients via a modified Van Herk Margin Form...

Reproducibility of Target Position during Surface-Guided Breath-Hold Adaptive SBRT of Liver Cancer

Authors: Lili Chen, Xiaoming Chen, Chang Ming Charlie Ma, Joshua Meyer

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose: Fast CBCT (HyperSight) acquisition technique together with a surface-guided breath-hold (SGBH) would allow a better image quality for accurate target/organ delineation. It facilitates breath-...

Retrospective Evaluation of Combined Photon SBRT and Radium-223 SPECT Based Radiopharmaceutical Therapy Tumor Dosimetry in Clinical Trial Patient Cases

Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang

Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill

Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...

Stereotactic Body Radiosurgery for Refractory Ventricular Tachycardia: Presenting Efficient Clinic Workflow, Dosimetric Analysis and Patients Reported Clinical Results

Authors: Karam Ayoub, Aaron B Hesselson, Ronald C McGarry, Joshua Misa, Damodar Pokhrel

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Department of Cardiology

Abstract Preview: Purpose: Noninvasive stereotactic body radiosurgery (SBRS) is emerging treatment option for advanced heart failure patients with refractory-ventricular tachycardia (rVT) who experienced recurrent impl...

Study of PSMA-PET/MR Biomarkers for Prostate Stereotactic Radiotherapy Planning

Authors: Guillermo Daniel Alvarez, Daniel Fino, Rocio Luz Gilli, Dorian Alexander Romero

Affiliation: School Foundation of Nuclear Medicine, INTECNUS Foundation, Nuclear Medicine and Radiotherapy Center of Southern Patagonia

Abstract Preview: Purpose: To evaluate the anatomical, functional, and molecular information from PET/MR images with F18-PSMA to identify intraprostatic lesions and delineate a boost in stereotactic body radiotherapy (...

The Development of Large Field MR Guided Radiotherapy for Pelvic Lymph Node SBRT and Its Dosimetry Improvement

Authors: David Byun, Ting Chen, Paulina E. Galavis, Allison McCarthy, Hesheng Wang, Michael J Zelefsky

Affiliation: NYU Langone Health

Abstract Preview: Purpose: To summarize a MR guided adaptive workflow developed for pelvic lymph nodes (PLN) stereotactic radiotherapy using large field size on Elekta UnityΒ© MR Linac system, and to quantitatively anal...

The Use of a Milled NIST Traceable Tld for End-to-End Validation in Mlc and Cone SRS Programs.

Authors: Ross Bland, Zachary A. Christ, Sophy Mangana, Feba Mathew, Stephanie K. Phoenix, Joseph Salloum, Jason D. Stanford, William Zollinger

Affiliation: Forrest General Cancer Center, Northeast Louisiana Cancer Institute, Florida Atlantic University

Abstract Preview: Purpose: The objective of this paper is twofold: 1) to explore the efficacy of using referenced beam models supplied by the vendor (Brainlab) and 2) the efficacy of NIST traceable TLD for end-to-end v...

Three-Dimensional Reconstruction of Triggered Images with Dehazing Algorithm for Precise Intrafraction Motion Detection in Spine SBRT

Authors: Hyosung Cho, Dae Yup Han, Duhee Jeon, Jiwon Park, Hyesun Yang

Affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, Yonsei University

Abstract Preview: Purpose: To precisely detect intrafraction patient motion during spine stereotactic body radiotherapy (SBRT) treatment delivery, we propose an optimized technique for three-dimensional reconstruction ...

Using Single-Energy Bragg Peak (SEBP) Flash Combined with Intensity-Modulated Proton Therapy (IMPT) for Flash Treatment in a Clinical Synchrotron-Based Proton System

Authors: Chingyun Cheng, Ben Durkee, Carri K. Glide-Hurst, Minglei Kang, Haibo Lin, Bhudatt R. Paliwal, Charles B. Simone, Zhizhen Wei, Tengda Zhang, Xingyi Zhao

Affiliation: University of Wisconsin, Department of Mechanical Engineering, University of Wisconsin-Madison, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: Transmission Beam (TB), Single-Energy Bragg Peak (SEBP), and Single-Energy Spread-Out Bragg Peak (SESOBP) are primary proton conformal FLASH techniques. However, each comes with significant l...