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Results for "preclinical trials": 4 found

Development of Preclinical Multiscale Dosimetry for Beta-Particle Emitting Radionuclide in Radiopharmaceutical Therapy

Authors: Adedamola Adeniyi, Bryan Bednarz, Malick Bio Idrissou, Reinier Hernandez, Ohyun Kwon, Brian W. Miller, Zachary S Morris, Maya Takashima, Jamey Weichert

Affiliation: Departments of Radiation Oncology and Medical Imaging, University of Arizona, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Radiology, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin–Madison

Abstract Preview: Purpose: As radiopharmaceutical therapy (RPT) becomes more prevalent in clinical applications, understanding dose-response relationships in the tumor microenvironment (TME) and normal tissues is essen...

Intra-Organ Blood Vessel Mapping in Mice for Improved Pre-Clinical Radiation Dosimetry

Authors: Daylin Barroso, Chris Beekman, Wesley E. Bolch, Natalia Estefania Carrasco-Rojas, Robert Joseph Dawson, Walter Murfee, Harald Paganetti, Andrew Robert Sforza, Julia D. Withrow

Affiliation: Massachusetts General Hospital - Harvard Medical School, Massachusetts General Hospital, University of Florida

Abstract Preview: Purpose: To develop methods for quantifying the interaction of radiation with blood in the mouse whole body (MOBY) phantom for dosimetric applications. The most important of these are modeling the dis...

Optimal Choice of Companion Radiotracer for TAT 225Ac-Mti-201.

Authors: Vinay K Banka, Mikalai Budzevich, William R. Gibbons, Mark L. McLaughlin, Jacob Moriarty, Eduardo G. Moros, David L. Morse, Christopher J. Tichacek, Thad J. Wadas

Affiliation: Modulation Therapeutics Inc, Moffitt Cancer Center, University of Iowa

Abstract Preview: Purpose: A targeted alpha therapy drug, 225Ac-MTI-201, has been developed targeting the Melanocortin 1 Receptor for metastatic uveal melanoma and is currently in FIH clinical trials. Since alpha emiss...

Slit Scanning Delivery Simulation for Flash Radiotherapy

Authors: Muhammad Ramish Ashraf, Dixin Chen, Aaron Garza, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner, Murat Surucu

Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: FLASH radiotherapy, supported by robust preclinical evidence showing an improved therapeutic index, is advancing toward clinical trials. Clinical FLASH treatments will likely require scanning...