Authors: Jiayi Chen, Manju Liu, Ning Wen, Haoran Zhang, Yibin Zhang
Affiliation: Department of Radiation Oncology, Ruijin Hospital, Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Duke Kunshan University, Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Abstract Preview: Purpose: This study introduces a novel Dual Energy CT (DECT)-Guided Intelligent Radiation Therapy (DEIT) platform designed to streamline and optimize the radiotherapy process. The DEIT system combines...
Authors: Liu Hong, Wen C. Hsi, Faraz Kalantari, Romy Megahed, Ganesh Narayanasamy, Maida Ranjbar, Pouya Sabouri, Zhong Su
Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)
Abstract Preview: Purpose: Quantitative apparent diffusion coefficients (ADC) in diffusion-weighted MRI (dMRI) reflect water diffusivity and thus provide tissue cellular density information. Functional diffusion mappin...
Authors: Yunxiang Li, Xinlong Zhang, You Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Acquiring high-resolution (HR) proton density (PD) images is time-consuming, while lower-resolution (LR) PD scans are faster but can lack sufficient details. We propose CycleHR, a T2-contrast...
Authors: Hungcheng Hank Chen, Laura A. Doyle, Helena Frisbie-Firsching, Amy S. Harrison, Jackson D Reeves, Lindsay B Romak, Jon Strasser
Affiliation: Christiana Care
Abstract Preview: Purpose: Brass mesh bolus (BMB) is a high-density woven metal mesh which is an excellent alternative to tissue equivalent bolus in photon beams, offering improved surface conformality. Unlike utilizat...
Authors: Ergun E. Ahunbay, Abdul Parchur, Eric S. Paulson, Ilaria Rinaldi, Angelo Schiavi, Li Zhao
Affiliation: Sapienza University of Rome, Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: Online adaptive replanning is often necessary in Intensity Modulated Proton Therapy (IMPT) due to the sensitivity of proton dose distributions to daily anatomical changes. A rapid, automated ...
Authors: Matthew J Ferris, Jason K Molitoris
Affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, University of Maryland
Abstract Preview: Purpose: Anatomy changes often happen in head-and-neck (HN) patients treated with proton radiation therapy. These changes can result in deteriorations of target dose coverage and increased dose to org...
Authors: Mark E Artz, Julie Bradley, Hardev Singh Grewal, Perry B. Johnson, Christina Klassen, Raymond Mailhot Vega, Nancy Mendenhall, Jiyeon Park, Emma V. Viviers, Yawei Zhang
Affiliation: UF Health Proton Therapy Institute, University of Florida
Abstract Preview: Purpose: Verification CTs (VFCT) are used in radiotherapy to assess patient dose during treatment. However, they are time-consuming and contribute additional radiation exposure to the patient. This st...
Authors: Wen C. Hsi, Pouya Sabouri, Zhong Su
Affiliation: University of Arkansas for Medical Sciences, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)
Abstract Preview: Purpose:
Traditional single-energy CT (SECT) contrast scans cannot be used for proton dose calculations due to significantly higher HU caused by iodine. Dual-layer dual-energy CT (DL-DECT) can dire...
Authors: Maria F. Chan, Indra J. Das, Xiuxiu He, Seng Boh Gary Lim, Jeonghoon Park, Yunjie Yang
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: There is a need for accurate and flexible in-vivo dosimetry systems, particularly for special procedures. Effective dosimetry is crucial for dose verification and maintaining records. A new r...
Authors: Serdar Charyyev, Cynthia Fu-Yu Chuang, Veng Jean Heng, Lianli Liu, Lei Xing, Yong Yang
Affiliation: Department of Radiation Oncology, Stanford University
Abstract Preview: Purpose: To replace large finite-size photon phase space files with a compact neural network capable of generating an infinite number of particles.
Methods: Three separate models were developed to ...
Authors: Matthew Stephen Andriotty, Taoran Cui, Harold Y Hu, Ke Nie, Tan Phan, Xiao Wang, Ning J. Yue, Chengzhu Zhang
Affiliation: Rutgers Cancer Institute of New Jersey, Basis Scottsdale
Abstract Preview: Purpose: Metallic implants are often non-isocentric, and their exact volumes/orientations/shapes are difficult to capture and contour accurately on CT images even if that information is known beforeha...
Authors: Indra J. Das, Ahtesham Ullah Khan, Andrew J. White
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine
Abstract Preview: Purpose: Small field dosimetry presents challenges due to lateral disequilibrium and the selection of suitable detectors. Volume averaging and density corrections hamper accurate profile measurements....
Authors: Carlos E. Cardenas, Udbhav S. Ram, Marcin Wierzbicki
Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham, Juravinski Cancer Centre
Abstract Preview: Purpose:
This study aims to systematically evaluate the dosimetric properties and delivery efficiency of 6X-FFF and 10X-FFF beams for lung SBRT on the Varian TrueBeam STx using the Eclipse TPS 16.1...
Authors: Li Tong, Chuyan Wang, Zhengkui Wang, Yingli Yang, Jie Zhang
Affiliation: Shanghai United imaging Healthcare Advanced Technology Research Institute, Shanghai United Imaging Healthcare Co., LTD, Department of Radiology, Ruijin Hospital, Institute for Medical Imaging Technology, Ruijin Hospital
Abstract Preview: Purpose:
Pelvic radiotherapy (RT)-induced bone marrow (BM) damage affects patient prognosis by causing hematologic toxicity. However, consensus on BM-sparing (BMS) RT is still lacking, owing to the...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Renan Felix dos Santos, Gustavo Freire Pereira da Silva, Alessandra Tomal
Affiliation: University of São Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de Física Gleb Wataghin
Abstract Preview: Purpose: Evaluate the feasibility of a bench-top PCCT using Geant4 Monte Carlo simulations. The study applied the Geant4 framework on determining the electronic density of materials as a function of C...
Authors: Niels Bassler, Jonathan Bortfeldt, Davide Boscaini, Francesco Evangelista, Guyue Hu, Ze Huang, Margarita Kozak, Julie Lascaud, Giulio Lovatti, Eero Lönnqvist, Jasper Nijkamp, Munetaka Nitta, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Babak Sharifi, Brita Singers Sørensen, Peter Thirolf
Affiliation: Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital
Abstract Preview: Purpose: To perform the first in vivo application of a novel small animal radiation research platform combining on-board image-guidance with multi-field intensity modulated spot scanning delivery [1] ...
Authors: Qianyi Xu, Inhwan Yeo
Affiliation: INOVA Schar Cancer Institute, Thomas Jefferson University
Abstract Preview: Purpose:
Four-dimensional computed tomography(4DCT) is prone to a geometrical error when respiration changes upon patient shift. 4DCT with a longer-length detector(16cm), uninvolving the shift, has...
Authors: Xiangli Cui, Wei Han, Jie Li, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences
Abstract Preview: Purpose: To investigate the influence of tissue heterogeneity on proton beam linear energy transfer (LET) and relative biological effectiveness (RBE) using nine RBE models. This study quantifies the i...
Authors: Amy Berrington de Gonzalez, Keith T Griffin, Jae Won Jung, Cari M Kitahara, Choonik Lee, Choonsik Lee, Aimee L McNamara, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock
Affiliation: University of Michigan, East Carolina University, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School, Institute of Cancer Research
Abstract Preview: Purpose: Radiotherapy dose reconstruction enables retrospective epidemiological studies that connect late health effects to the organ-absorbed radiation doses received during treatment. Though clinica...
Authors: Davide Brivio, Erno Sajo, Ryan Williams, Piotr Zygmanski
Affiliation: University of Massachusetts Lowell, Brigham and Women's Hospital, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School
Abstract Preview: Purpose: To develop a non-invasive 3D in-vivo dosimetry tool exploring the relationship between positron annihilations and dose per voxel using Monte Carlo simulation. The Positron Guided Radiation Th...
Authors: Hania A. Al-Hallaq, Duncan Henry Bohannon, Chih-Wei Chang, Anees H. Dhabaan, Vishal Dhere, H Scott McGinnis, Pretesh Patel, Sagar Patel, Keyur Shah, Xiaofeng Yang, Jun Zhou
Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose: Two-fraction proton SABR is an attractive alternative to brachytherapy for localized prostate cancer. However, potential interfractional anatomical changes necessitate online adaptation, espe...
Authors: Catherine Coolens, Robert K. Heaton, Lalageh Mirzakhanian, Tasnim Rahman, Jan P. Seuntjens
Affiliation: Princess Margaret Cancer Centre & University of Toronto, McGill University, Princess Margaret Cancer Centre, Princess Margaret Hospital, University of Toronto
Abstract Preview: Purpose: Commissioning of a Gamma Knife® (GK) (Elekta, Sweden) unit requires precise dosimetric reference measurements, particularly for small fields. The IAEA TRS-483/AAPM TG-155 code of practice (20...
Authors: Kaitlyn M Betz, David Dunkerley, Eric Johnson, Kalina V Jordanova, Kathryn E. Keenan, Samuel D Oberdick, Gregory P. Penoncello, Stephen E Russek
Affiliation: Dept of Radiology, Stanford, University of Colorado School of Medicine, NIST, College of Wooster
Abstract Preview: Purpose: Examine use of low-field MRI and multiparametric analysis for 3D MRI-readable biomimetic gel dosimetry. Low-field MRIs are compact, inexpensive, and portable. They could be located within rad...
Authors: Peymon Ghazi
Affiliation: MALCOVA Inc.
Abstract Preview: Purpose: To develop a near scatter‐free breast CT imaging system that expands coverage of the posterior breast anatomy and enhances contrast resolution for solid masses and microcalcifications, while ...
Authors: Mohammed Alzaabi, Abderaouf Behouch, Nabil Maalej, Aamir Raja, Briya Tariq
Affiliation: Khalifa University
Abstract Preview: Purpose: Spectral Photon Counting CT (SPCCT) has emerged as a transformative technology in CT imaging capable of producing images from distinct energy windows, allowing improved material characterizat...
Authors: Carina Gassner, Guyue Hu, Thomas Kröncke, Christopher Kurz, Guillaume Landry, Katharina Niepel, Katia Parodi, Franka Risch, Florian Schwarz
Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Diagnostic and Interventional Radiology, University Hospital Augsburg, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich)
Abstract Preview: Purpose: To evaluate the performance of a clinical photon-counting CT (PCCT) scanner in terms of proton relative stopping power (RSP) estimation using PCCT data and to compare the impact of different ...
Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey, Taylor Ransom
Affiliation: Thompson Proton Center, University of Tennessee
Abstract Preview: Purpose: Proton pencil beam scanning can reduce normal tissue dose but is highly sensitive to setup, anatomical changes, and range variations. These uncertainties may compromise target coverage and or...
Authors: Lizbeth Ayala-Dominguez, Aaron L Carrel, Diego Hernando, Gabrielle L Hoffmann, Amber Possell, Ivan M. Rosado-Mendez, Jiayi Tang, Andrew Wentland
Affiliation: Department of Pediatrics, University of Wisconsin-Madison, Department of Radiology, University of Wisconsin-Madison, Department of Medical Physics, University of Wisconsin-Madison, Departments of Medical Physics and Radiology, University of Wisconsin-Madison
Abstract Preview: Purpose: Metabolic dysfunction-associated steatotic liver disease (MAFLD) is the leading cause of chronic liver disease in children. While biopsy remains the diagnostic standard, non-invasive imaging ...
Authors: Yao Hao, Yuting Peng, Francisco Javier Reynoso, Tianyu Zhao, Xiandong Zhao
Affiliation: Varian, University of South Florida, Washington University School of Medicine, Washington University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose: Ultra-high dose-rate (FLASH) dose rate (> 40 Gy/s) may result in a radio-protective effect in healthy tissue compared with conventional dose rate (CDR). This effect has been observed in vivo ...
Authors: Michael Dingfelder
Affiliation: East Carolina University
Abstract Preview: Purpose:
To study and accurately evaluate the influence of the Fermi Density effect on stopping powers and cross sections of charged particles in liquid water used in Monte Carlo radiation transpor...
Authors: Eric S. Diffenderfer, Lei Dong, Alejandro Garcia, Wenbo Gu, Michele M. Kim, Alexander Lin, Kai Mei, Peter B. Noël, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: We present a novel 3D-printed range-modulating devices with spatially modulated density for FLASH particle therapy. By varying density distributions, spread-out Bragg peaks(SOBPs) can be gene...
Authors: Harold Y Hu, Yanle Hu, Shuai Leng, Maryam Sadeghian, Joe Swicklik
Affiliation: Mayo Clinic Arizona, Basis Scottsdale, Mayo Clinic
Abstract Preview: Purpose: Radiotherapy CT simulation often requires two scans: a non-contrast scan for dose calculation and a contrast-enhanced scan for target delineation. Photon-counting-detector (PCD) CT allows the...
Authors: Duncan Henry Bohannon, Pretesh Patel, Sibo Tian, Yinan Wang, Xiaofeng Yang, Ahmal Jawad Zafar, Jun Zhou
Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose:
4D robust optimization, incorporating additional images (e.g., maximum inhale/exhale phases), is commonly used to account for target motion in proton treatment planning. However, the incre...