Authors: Fu-Xiong Chang, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Nancy Y Lee, Chih-Hsun Lin, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Pingfang Tsai, Shouyi Wei, Irini Yacoub, Yunjie Yang, Ajay Zheng, Jun Zhou
Affiliation: New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Liverage Biomedical Inc., Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Institute of Physics, Academia Sinica
Abstract Preview: Purpose: FLASH therapy presents an opportunity to alter the radiotherapy paradigm and significantly enhancing normal organ protection while maintaining the effectiveness of tumor control. The temporal...
Authors: Arpit M. Chhabra, J Isabelle Choi, Minglei Kang, Haibo Lin, Hang Qi, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Xingyi Zhao, Ajay Zheng
Affiliation: New York Proton Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose:
Pencil beam scanning (PBS) proton therapy effectively treats ocular cancer by minimizing exit doses to normal tissues. However, challenges remain in sparing nearby organs-at-risk(OARs). Ul...
Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou
Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose:
We propose a method to optimize adaptive proton FLASH therapy (ADP-FLASH) using modularized pin-ridge filters (pRFs) by recycling module pins from the initial plan, reducing pRF adjustment...
Authors: Amir Abdollahi, Celine Karle, Michele M. Kim, Constantinos Koumenis, Andrea Mairani, Erato Stylianou Markidou
Affiliation: Heidelberg Ion-Beam Therapy Center - Department of Radiation Oncology, German Cancer Research Centre(DKFZ), University of Pennsylvania, Physics Dep. University of Cyprus
Abstract Preview: Purpose: The aim is to compare FLASH dose-rate RT generated with protons and carbon (HIT) and compare to protons (UPenn) to provide evidence for equipotency of FLASH vs. standard RT to tumor growth co...
Authors: Ronald C Chen, Hao Gao, Nicolas Gerard, Harold Li, Yuting Lin, Jarrick Nys, Jufri Setianegara, Mark Szczepanski, Aoxiang Wang
Affiliation: 4Physikalisch-Technische Werkstätten (PTW), Department of Biomedical Engineering, Huazhong University of Science and Technology, Ion Beam Applications (IBA), Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Modern synchrocyclotrons can produce magnetically-scanned protons at ultra-high dose-rates (FLASH). However, their pulsed nature leads to high doses-per-pulse (DPP) which can cause non-neglig...
Authors: Gulakhshan M Hamad, Sina Mossahebi, Yannick P. Poirier, Amit Sawant
Affiliation: University of Maryland School of Medicine, Maryland University Baltimore
Abstract Preview: Purpose:
The combination of ultra-high dose rate (UHDR) proton therapy, known for normal tissue sparing, with spatially-fractionated radiotherapy (SFRT), promising enhanced tumor control and tissue...
Authors: Ahmet S. Ayan, Austin M. Faught, Eunsin Lee, Julia Pakela
Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Ohio State University, The Ohio State University
Abstract Preview: Purpose: To present commissioning of a fixed beamline ultra-high dose rate proton pencil beam scanning system, the world’s first multi-room Varian ProBeam360⁰
Methods: The fixed beamline pencil bea...
Authors: Julien Forthomme, Carolina Llina Fuentes, Valentin Hamaide, Lucian Hotoiu, Rudi Labarbe, Rasmus Nilsson, Arnaud Pin, Francois Vander Stappen, Erik Traneus
Affiliation: RaySearch Laboratories AB, Ion Beam Applications SA
Abstract Preview: Purpose: Conformal FLASH achieves ultra-high-dose-rate (UHDR) proton therapy (>40 Gy/sec) by scanning a mono-energetic pencil beam through accessories (range shifter, Conformal Energy Modulator, apert...
Authors: Petr Bruza, Megan Clark, David J. Gladstone, Joseph Harms, Anthony E. Mascia, Brian W Pogue, Roman Vasyltsiv, Zhiyan Xiao, Rongxiao Zhang, Yongbin Zhang
Affiliation: Cincinnati Children's Proton Therapy Center, University of Missouri, Dartmouth College, Thayer School of Engineering, Dartmouth College, Washington University in St. Louis, University of Wisconsin - Madison
Abstract Preview: Purpose: With developing FLASH trials requiring diligent delivery monitoring, current proton therapy in-vivo dosimetry (IVD) cannot provide comprehensive verification, including dose and dose-rate vol...
Authors: Jean Dessureault, Malcolm R. McEwen, Bryan R. Muir, James Renaud
Affiliation: National Research Council
Abstract Preview: Purpose: To develop and commission a mailable calorimeter that enables clinical medical physicists to quickly and efficiently address innovative dosimetry challenges directly at the point of use.
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Authors: Zongsheng Hu, Yuting Li, Radhe Mohan, Emil Schueler, Uwe Titt
Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: In previous work, we developed an irradiation system for pre-clinical ultra-high-dose-rate(FLASH) radiotherapy experiments based on synchrotron proton beamline. However, the beam current limi...
Authors: Luke Connell, Nolan M. Esplen, Elise Konradsson, Albert C. Koong, Ziyi Li, Steven Hsesheng Lin, Kevin Liu, Billy W Loo, Devarati Mitra, Radhe Mohan, Emil Schueler, Takeshi Takaoka, Uwe Titt, Xiaochun Wang, Ming Yang
Affiliation: The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: This study aimed to assess radiation-induced gastrointestinal (GI) toxicity in mice subjected to abdominal irradiation using protons at ultra-high-dose-rate (UHDR) and conventional dose-rates...
Authors: Chin-Cheng Chen, Chingyun Cheng, Longfei Diao, Benjamin Durkee, Minglei Kang, Haibo Lin, LeLe Liu, Yangguang Ma, Xuanqin Mou, YunTong Pei, Charles B. Simone, YuFei Wang, Xueqing Yan, Xingyi Zhao, Wang Zhengda
Affiliation: Peking University, St. Jude Children's Research Hospital, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, School of Software Engineering, Xi’an Jiaotong University, School of information and communications engineering, Faculty of electronic and information engineering, Xi’an Jiaotong University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: This study evaluates the effectiveness of apertures in improving lateral dose falloff in proton pencil beam scanning (PBS) single-energy Bragg peak (SEBP) FLASH radiotherapy (RT). The approac...
Authors: Christopher Bartee, Justin Riley DeFrancisco, Marcos Feijoo, Siyong Kim, Tianjun Ma
Affiliation: Blue Physics LLC, Virginia Commonwealth University
Abstract Preview: Purpose: Irradiation with FLASH has been shown to decrease normal tissue toxicity while maintaining similar tumor control. To advance FLASH into the clinic, more preclinical investigations are first n...
Authors: Jack Biondo, Audrey Magness, Anthony E. Mascia, Zhiyan Xiao, Yongbin Zhang
Affiliation: Cincinnati Children's Proton Therapy Center
Abstract Preview: Purpose: Proton FLASH-RT has shown promise reducing normal tissue toxicity while maintaining tumor control. However, in vivo experiments critically depend on achieving ultra-high dose rate (UHDR) and ...
Authors: Seohyeon An, Yoonsun Chung, Seonghoon Jeong, Seongmoon Jung, Chae-Eon Kim, In Jung Kim, Sung Hun Kim, Se Byeong Lee, Sang-il Pak, Jong In Park
Affiliation: POHANG ACCELERATOR LABORATORY, Hanyang University, Korea Research Institute of Standards and Science (KRISS), Ilsan Paik Hospital, National Cancer Center, National Cancer Center Korea, Korea Research Institute of Standards and Science
Abstract Preview: Purpose: To evaluate the performance of three ion chambers—Advanced Markus (AMC), PinPoint, and Roos—under FLASH proton beam conditions and assess the response of the nozzle monitor chamber for their ...
Authors: Davide Brivio, Lia Carroll, Juliane Daartz, Jan PO Schuemann, Piotr Zygmanski
Affiliation: Massachusetts General Hospital, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: We employ High-Energy Current (HEC) detectors for real-time monitoring of proton beams at conventional to FLASH dose rates. This would help overcome the need for fast and accurate dosimeters ...
Authors: Xun Jia, Heng Li, Wen Li, Devin Miles, Daniel Sforza, Lingshu Yin, Yuncheng Zhong
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University
Abstract Preview: Purpose: FLASH therapy holds great potential to revolutionize radiotherapy by minimizing toxicities of normal tissues. The extraordinarily high dose rate of FLASH proton beam makes precise delivery to...
Authors: Ning Cao, Sunan Cui, Danielle P. Johnson Erickson, Juergen Meyer, Ramesh Rengan, Ben A Shaver, Jing Zeng
Affiliation: Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, University of Washington and Fred Hutchinson Cancer Center, University of Washington
Abstract Preview: Purpose: To investigate the immune response in primary irradiated tumors and non-irradiated tumors in a mouse melanoma xenograft model, comparing 18Gy of conventional (CONV) and ultra-high dose rate (...
Authors: Jacqueline M. Andreozzi, Savannah Decker, Diego Hernandez, Iman R. Washington
Affiliation: UC San Diego, Department of Radiation Oncology, Moffitt Cancer Center, University of South Florida, Moffitt Cancer Center
Abstract Preview: Purpose: Recent advances in external beam radiation therapy have begun to explore the utility of Cherenkov radiation imaging as a beam delivery visualization tool. When sheet bolus is used during trea...
Authors: Hansong Bai, Peter Jermain, Xun Jia, Heng Li, Devin Miles, Daniel Sforza, Michael H. Shang, Daniel Robert Strauss, Keith Unger, Lingshu Yin
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, MedStar Georgetown University Hospital, Johns Hopkins University, Department of Radiation Medicine, MedStar Georgetown University Hospital
Abstract Preview: Purpose: To investigate DNA Double Strand Break (DSB) induced by FLASH proton irradiation in a repair-free plasmid DNA model under different free radical scavenging conditions in plateau and Bragg pea...
Authors: Yuqi Yang, Fang-Fang Yin
Affiliation: Duke Kunshan University, Medical Physics Graduate Program, Duke Kunshan University
Abstract Preview: Purpose: Reactive oxygen species (ROS) are unstable molecules which play important roles in the cellular process after Flash radiotherapy. The rapid changes in ROS levels during treatment may provide ...
Authors: Hao Gao, Jiayue Han, Wangyao Li, Yuting Lin, Jufri Setianegara, Aoxiang Wang, Yanan Zhu
Affiliation: Department of Biomedical Engineering, Huazhong University of Science and Technology, Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Proton therapy leverages Bragg-peak-based dose delivery to achieve ultra-high-dose-rate FLASH with patient-specific range modulators (PSRM). Current proton FLASH (pFLASH) planning typically i...
Authors: Michael M Folkerts, Miriam Krieger, Pierre Lansonneur, Gerard Paquet, Petar Penchev, Christoph Schuy, Yuri Simeonov, Uli Weber, Klemens Zink
Affiliation: GSI Helmholtzzentrum fuer Schwerionenforschung, Institute of Medical Physics and Radiation Protection (IMPS), University of Applied Sciences, Varian Medical Systems
Abstract Preview: Purpose:
Ultra-high dose-rate proton irradiation may spare the healthy tissue (FLASH-effect). The 3D-range-modulator (3D-RM) method reduces the treatment time compared to conventional IMPT and can ...
Authors: Ana Maria Barragan Montero, Damien Dasnoy, Sylvain Deffet, Valentine Dormal, Colin Gaban, Melanie Ghislaine, Valentin Hamaide, Guillaume Janssens, John A. Lee, Eliot Peeters, Danah Pross, Luciano Rivetti, Benjamin Roberfroid, Romain Schyns, Kevin Souris, Edmond S. Sterpin, Sophie Wuyckens
Affiliation: Ion Beam Applications SA, Hospital Riviera-Chablais, UCLouvain, Multitel, Université Catholique de Louvain, IBA, Faculty of Mathematics and Physics, University of Ljubljana, Universite Catholique de Louvain
Abstract Preview: Purpose: Treatment planning systems (TPSs) are essential for simulating and optimizing radiotherapy treatments. However, clinical TPSs are expensive software commercialized by private companies and of...
Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng
Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...
Authors: Yuting Lin
Affiliation: Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: N/A...
Authors: Alexandru Badalan, Peter Petric, I. Antoniu Popescu, Andrew Kyle Henderson Robertson
Affiliation: Bc Cancer, BC Cancer - Vancouver, BC Cancer
Abstract Preview: Purpose: Ultra-high dose rate (>40 Gy/s) or “FLASH” radiation therapy (RT) has the potential to improve cancer treatment through reduced radiation side effects. While electron FLASH beams can be produ...
Authors: Yao Hao, Yuting Peng, Francisco Javier Reynoso, Tianyu Zhao, Xiandong Zhao
Affiliation: Varian, University of South Florida, Washington University School of Medicine, Washington University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose: Ultra-high dose-rate (FLASH) dose rate (> 40 Gy/s) may result in a radio-protective effect in healthy tissue compared with conventional dose rate (CDR). This effect has been observed in vivo ...
Authors: Alexander Baikalov, Luke Connell, Nolan M. Esplen, Michele M. Kim, Stephen F. Kry, Emil Schueler, Hayden Scott, Ryan Sun, Paige A. Taylor, Uwe Titt
Affiliation: The University of Texas MD Anderson Cancer Center, University of Pennsylvania, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: to develop an affordable, portable device for accurately measuring FLASH dose rates from protons, electrons, and photons. 4 detectors were utilized to measure the temporal structure of proton...
Authors: Muhammad Ramish Ashraf, Dixin Chen, Aaron Garza, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner, Murat Surucu
Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: FLASH radiotherapy, supported by robust preclinical evidence showing an improved therapeutic index, is advancing toward clinical trials. Clinical FLASH treatments will likely require scanning...
Authors: Jenghwa Chang, Chingyun Cheng, J Isabelle Choi, Muhammad Hamza, Minglei Kang, Tyler Kaulfers, Grant Lattery, Haibo Lin, Charles B. Simone, Xingyi Zhao
Affiliation: Peking University, Hofstra University Medical Physics Program, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Physics and Astronomy, Hofstra University, Physics Resident at Montefiore Einstein, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: In terms of high dose rate FLASH, the question remains on how to properly deliver treatment and what clinical sites are feasible to deliver such treatment. The novel Bragg peak (BP-FLASH) and...
Authors: Yujie Chi, Yao Hao, Xun Jia, Youfang Lai, Yuting Peng, Francisco Javier Reynoso, Lingshu Yin, Tianyu Zhao, Xiandong Zhao
Affiliation: Johns Hopkins University, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Physics, University of Texas at Arlington, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, University of South Florida
Abstract Preview: Purpose: FLASH radiation therapy has shown remarkable tissue sparing effects compared to radiation therapy at conventional dose rates (CDR). Yet, its mechanism remains unclear. Radical production modu...
Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Yinan Wang, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou
Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose: Active breath-hold techniques effectively mitigate respiratory motion but poses challenges for patients who are unable to tolerate the procedure. Conventional planning relies on multiple ener...
Authors: Eric S. Diffenderfer, Lei Dong, Alejandro Garcia, Wenbo Gu, Michele M. Kim, Alexander Lin, Kai Mei, Peter B. Noël, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: We present a novel 3D-printed range-modulating devices with spatially modulated density for FLASH particle therapy. By varying density distributions, spread-out Bragg peaks(SOBPs) can be gene...
Authors: Chingyun Cheng, Ben Durkee, Carri K. Glide-Hurst, Minglei Kang, Haibo Lin, Bhudatt R. Paliwal, Charles B. Simone, Zhizhen Wei, Tengda Zhang, Xingyi Zhao
Affiliation: University of Wisconsin, Department of Mechanical Engineering, University of Wisconsin-Madison, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: Transmission Beam (TB), Single-Energy Bragg Peak (SEBP), and Single-Energy Spread-Out Bragg Peak (SESOBP) are primary proton conformal FLASH techniques. However, each comes with significant l...