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Results for "proton pencil": 56 found

A 2D Discrete Ionization Chamber Array for Proton Pencil Beam Scanning Flash Dosimetry

Authors: Fu-Xiong Chang, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Nancy Y Lee, Chih-Hsun Lin, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Pingfang Tsai, Shouyi Wei, Irini Yacoub, Yunjie Yang, Ajay Zheng, Jun Zhou

Affiliation: New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Liverage Biomedical Inc., Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Institute of Physics, Academia Sinica

Abstract Preview: Purpose: FLASH therapy presents an opportunity to alter the radiotherapy paradigm and significantly enhancing normal organ protection while maintaining the effectiveness of tumor control. The temporal...

A Causal Machine Learning Analysis of Dosimetric and Clinical Predictors of Osteoradionecrosis in Head and Neck Cancer Radiotherapy

Authors: Jingyuan Chen, Sheng Li, Tianming Liu, Wei Liu, Zhengliang Liu, Zhong Liu, Daniel Ma, Samir H. Patel, Guangya Wang, Yunze Yang

Affiliation: University of Miami, Mayo Clinic, School of Data Science, University of Virginia, School of Computing, University of Georgia, Department of Radiation Oncology, Mayo Clinic, Institute of Western China Economic Research, Southwestern University of Finance and Economics

Abstract Preview: Purpose:
Traditional patient outcome analyses relied heavily on conventional statistical models that primarily elucidate correlation rather than causal relationships. In this study, we aim to ident...

A Comparison of the Impact to Mean Doses to Organs at Risk of Small Versus Large Spot Sizes in Pelvic Proton Therapy

Authors: Jamie s Baker, Sam Beddar, Mahsa Dehghanpour, Ariel MT Hoang, Emma Holliday, Rachael M. Martin Paulpeter, Joshua S. Niedzielski, Luis Augusto Perles, Josie S Ruzek, Gabriel O. Sawakuchi

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, niversity of Texas MD Anderson Cancer Center School of Health Professions, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, University of Texas MD Anderson Cancer Center School of Health Professions

Abstract Preview: Purpose: This study aims to evaluate the dosimetric impact on organs at risk (OAR) of small versus large spot sizes when treating pelvic cancer patients with pencil beam scanning (PBS) proton therapy....

A Dosimetric Investigation into the Potential of Aperture-Based Techniques to Improve the Clinical Outcomes of Single-Energy Proton Bragg Peak Flash Therapy for Ocular Cancers

Authors: Arpit M. Chhabra, J Isabelle Choi, Minglei Kang, Haibo Lin, Hang Qi, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Xingyi Zhao, Ajay Zheng

Affiliation: New York Proton Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Pencil beam scanning (PBS) proton therapy effectively treats ocular cancer by minimizing exit doses to normal tissues. However, challenges remain in sparing nearby organs-at-risk(OARs). Ul...

A Dosimetric Study of Range-Compensated Proton Arc Therapy

Authors: Alonso N. Gutierrez, Daniel E. Hyer, Blake R. Smith

Affiliation: Miami Cancer Institute, Baptist Health South Florida, Iowa Health Care, University of Iowa

Abstract Preview: Purpose: To perform a feasibility study of optimizing and producing a compact range compensator to deliver single-energy pencil beam scanning (PBS) proton arc therapy treatments. Omitting energy chang...

A Monte Carlo Framework for Automated Quality Assurance of Dynamically Collimated Pencil Beam Scanning Clinical Treatment Deliveries

Authors: Laura Bennett, Wesley S. Culberson, Albert Du, Kevin J. Erhart, Ryan T. Flynn, Ryan Gardner, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Eric Jensen, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake

Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Ion Beam Applications (IBA), University of Iowa, Iowa Health Care, .decimal

Abstract Preview: Purpose: To develop and experimentally validate a novel Monte Carlo (MC) framework designed to enable calculation-based quality assurance (QA) for collimated intensity modulated proton therapy treatme...

A New Algorithm for Charged Particle Therapy Beam Energy Measurement By Time-of-Flight

Authors: Sung Woon Choi, Dong Wook Kim, Jin Sung Kim, Na Hye Kwon, Paulo Jorge Ribeiro Da Fonte

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Coimbra Institute of Engineering, Polytechnic University of Coimbra

Abstract Preview: Purpose: In hadrontherapy, such as proton and carbon ion therapy, it is desirable, for quality assurance reasons, to have an online beam energy measurement independent from the machine parameters. Sin...

A Quantitative Metric for Evaluating Treatment Plan Robustness in Intensity Modulated Proton Therapy

Authors: Grant Evans, Maxwell Arthur Kassel, Charles Shang, Stephen Shang

Affiliation: South Florida Proton Therapy Institute, SFPRF

Abstract Preview: Purpose: Proton pencil beam scanning therapy is particularly sensitive to field translational shifts and beam range variations, which can degradation of dose distribution and compromise the treatment....

Accuracy Assessment of Bragg Peak Imaging Using Protoacoustics at a Clinical Dose

Authors: Michael Caulfield, Ye Chen, Yoshihiro Ishi, Yasutoshi Kuriyama, Taeko Matsuura, Naoki Miyamoto, Taichi Murakami, Tomonori Uesugi, Kohei Yokokawa

Affiliation: Hokkaido University, Kyoto University, University of Alberta

Abstract Preview: Purpose: Protoacoustics has the potential for real-time and direct imaging of the Bragg peak. This study investigated the accuracy of the Bragg peak imaging based on the water phantom experiment at a ...

Adaptive Proton Flash Therapy through Iterative Modular Pin Recycling

Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou

Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose:
We propose a method to optimize adaptive proton FLASH therapy (ADP-FLASH) using modularized pin-ridge filters (pRFs) by recycling module pins from the initial plan, reducing pRF adjustment...

BEST IN PHYSICS THERAPY: Fast and Convenient Proton Pencil Beam Energy QA with Multi-Layer Faraday Cup (MLFC)

Authors: Paul Boisseau, Eric S. Diffenderfer, Andrew Friberg, Wenbo Gu, Matthew Nichols, Kan Ota, Xiaokun Teng, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou

Affiliation: Department of Radiation Oncology, University of Pennsylvania, Pyramid Technical Consultants, Inc., University of Pennsylvania

Abstract Preview: Purpose: Traditional quality assurance procedures for proton pencil beam energies involve water tank setups or multiple solid water phantoms and are time-consuming. This study demonstrates that an inn...

CNN-Based Reconstruction for 3D Scintillation Dosimetry of Proton Pencil Beams

Authors: Sam Beddar, Jason Michael Holmes, Daniel G. Robertson, James J. Sohn, Ethan D. Stolen

Affiliation: Department of Radiation Oncology, Mayo Clinic, MD Anderson Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Department of Radiation and Cellular Oncology, University of Chicago

Abstract Preview: Purpose: Camera-based scintillation dosimetry incorporating large volumes have shown promise for fast and comprehensive evaluation of external beam treatment fields. While some efforts have been made ...

Case-By-Case Analysis of Proton Spot Spacing and Dosimetric Variability in Proton Arc Lung Cancer Planning

Authors: Nebi Demez, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Umesh Rana, Nishan Shrestha, Somol Sunny

Affiliation: Florida Atlantic University, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: DynamicARC is an advanced proton therapy technique that leverages pencil beam scanning to deliver dose to the patient while the gantry rotates around the patient. This study investigates the ...

Clonogenic Assays for Three Prostate Cancer Cell Lines with Varying Levels of DNA Repair Mutations Treated with LET-Optimized Pencil Beam Scanning Protons and Evaluation of Dose Rate Effect

Authors: Mark E Artz, Jiyeon Park, Lori Rice, Mohammad Saki, Sanjeev Shukla, Michael Vieceli

Affiliation: University of Florida Health Proton Therapy Institute, Department of Radiation Oncology, University of Florida College of Medicine, UF Health Proton Therapy Institute, Department of Urology, University of Florida College of Medicine

Abstract Preview: Purpose: To investigate how varying levels of DNA repair mutations affect the LET sensitivity of prostate cancer cells.
Methods: The prostate cancer cell lines Du145 (low DNA repair mutations), PC3...

Commissioning a Fixed Beamline Ultra-High Dose Rate Proton Therapy System

Authors: Ahmet S. Ayan, Austin M. Faught, Eunsin Lee, Julia Pakela

Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Ohio State University, The Ohio State University

Abstract Preview: Purpose: To present commissioning of a fixed beamline ultra-high dose rate proton pencil beam scanning system, the world’s first multi-room Varian ProBeam360⁰
Methods: The fixed beamline pencil bea...

Commissioning and Validation of Monaco Proton Treatment Planning System on a Compact Proton Therapy System

Authors: Shupeng Chen, Xiaoda Cong, Raymond Dalfsen, Rohan Deraniyagala, Xuanfeng Ding, James E. Dolan, Xiaoqiang Li, Jian Liang, Peilin Liu, An Qin, Martin Soukup, Craig Stevens, Xiangkun Xu, Weili Zheng

Affiliation: Corewell Health William Beaumont University Hospital, Corewellhealth William Beaumont University Hospital, William Beaumont University Hospital, Elekta, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Corewellhealth William Beaumont Hospital, Department of Radiation Oncology, Corewell Health William Beaumont University Hospital

Abstract Preview: Purpose: To facilitate clinical use of the proton feature of Monaco treatment planning system(TPS), we commissioned and validated it on a compact proton therapy system.
Methods: Pencil Beam Scannin...

Conformal Flash for Large Treatment Fields

Authors: Julien Forthomme, Carolina Llina Fuentes, Valentin Hamaide, Lucian Hotoiu, Rudi Labarbe, Rasmus Nilsson, Arnaud Pin, Francois Vander Stappen, Erik Traneus

Affiliation: RaySearch Laboratories AB, Ion Beam Applications SA

Abstract Preview: Purpose: Conformal FLASH achieves ultra-high-dose-rate (UHDR) proton therapy (>40 Gy/sec) by scanning a mono-energetic pencil beam through accessories (range shifter, Conformal Energy Modulator, apert...

Data-Driven Forward Projector for Optimization of the Proton Stopping Power Calibration in Treatment Planning Based on Sparse Proton Radiographies

Authors: Hector Andrade-Loarca, Ines Butz, Chiara Gianoli, Prof. Gitta Kutyniok, Jianfei Li, Katia Parodi, Prof. Vincenzo Patera, Angelo Schiavi, Prof. Ozan Öktem

Affiliation: Sapienza University of Rome, Department of Mathematics, Royal Institute of Technology, School of Computation, Information and Technology, Technische Universitaet Muenchen, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Department of Mathematics, Ludwig-Maximilians-Universität (LMU) München, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München

Abstract Preview: Purpose: To explore and demonstrate the feasibility of accurate and fast prediction of the water equivalent thickness (WET) distribution of tissue traversed by a proton imaging pencil beam, aiming at ...

Deep Learning-Based Prompt Gamma Imaging for Proton Range Verification Using Patient Data Simulation

Authors: Mostafa Cham, Matthias K Gobbert, Zhuoran Jiang, Sina Mossahebi, Ruth Obe, Stephen W. Peterson, Jerimy C. Polf, Lei Ren, Ehsan Shakeri, Vijay Raj Sharma

Affiliation: University of Maryland School of Medicine, UMBC, University of Maryland Baltimore County, University of Maryland, Baltimore County, Stanford University, University of Maryland, School of Medine, Department of Physics, University of Cape Town, M3D, Inc, Department of Infomation Systems, UMBC

Abstract Preview: Purpose: Compton camera (CC)-based prompt gamma imaging (PGI) offers real-time proton range verification. However, its limited-angle measurements cause severe distortions in PGI, affecting its clinica...

Deep Learning–Based Dose Prediction for Automated Proton Radiation Therapy Planning of Breast Cancer

Authors: Ahssan Balawi, Peter Jermain, Timothy Kearney, Sonali Rudra, Michael H. Shang, Markus Wells, Mohammad Zarenia

Affiliation: Department of Radiation Medicine, MedStar Georgetown University Hospital

Abstract Preview: Purpose: To investigate the applicability and accuracy of a deep learning (DL) model in predicting radiation dose distribution for breast cancer patients treated with pencil-beam-scanning proton radio...

Design and Testing of a 3D-Winston-Lutz Phantom to Quantify Isocentricity of Pencil Beam Scanning Proton Therapy Machines

Authors: Imad M. Ali, Nesreen Alsbou, Baraa Kalani

Affiliation: Oklahoma State University, University of Central Oklahoma, University of Oklahoma Health Sciences Center

Abstract Preview: Purpose: To develop a three-dimensional Winston-Lutz phantom to quantify the isocentricity of the gantry, couch, and on-board imager of the MEVION-S250i proton therapy machine.
Methods: A 3D-scinti...

Design of a Small Animal Proton Flash Irradiation System with High Achievable Dose and Dose Rate Using a Synchrotron Proton Beamline

Authors: Zongsheng Hu, Yuting Li, Radhe Mohan, Emil Schueler, Uwe Titt

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: In previous work, we developed an irradiation system for pre-clinical ultra-high-dose-rate(FLASH) radiotherapy experiments based on synchrotron proton beamline. However, the beam current limi...

Determining Optimal Delivery Pattern for Reference Dosimetry in Pencil Beam Scanning Proton Therapy

Authors: Clifford Ghee Ann Chua, Calvin Wei Yang Koh, Kah Seng Lew, Zubin Master, Sung Yong Park, Hong Qi Tan, Andrew Wibawa

Affiliation: National Cancer Centre Singapore

Abstract Preview: Purpose: To investigate the impact of spot position deviation on reference dosimetry measurements using different delivery patterns and to determine the optimal delivery pattern for reference dosimetr...

Development of a GPU-Based Dose Calculation Engine for MRI-Guided Proton Therapy

Authors: Yaowen Cao, Haonian Gong, Yue Gu, Meiqi Liu, Hsiao-Ming Lu, Yuxiang Wang, Yidong Yang, Xiaogang Yuan

Affiliation: Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China

Abstract Preview: Purpose: Magnetic resonance imaging (MRI)-guided proton therapy is an innovative technology that combines superior soft tissue imaging capabilities of MRI with the high dose conformity of proton thera...

Dose Reconstruction from Prompt-Gamma Imaging Towards Real-Time Adaptive Proton Therapy

Authors: Thomas R. Bortfeld, Prof. Elisabetta De Bernardi, Tianxue Du, Beatrice Foglia, Chiara Gianoli, Takamitsu Masuda, Katia Parodi, Marco Pinto, Boon-Keng Kevin Teo, Yunhe Xie

Affiliation: Department Of Radiation Oncology, Massachusetts General Hospital (MGH), School of Medicine and Surgery, University of Milano-Bicocca, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, National Institutes for Quantum Science and Technology (QST), University of Pennsylvania, Department of Experimental Physics - Medical Physics, Ludwig-Maximilians-Universität (LMU) München

Abstract Preview: Purpose: The full potential offered by protons in clinical practice is limited by range uncertainties. One possibility for monitoring is through secondary prompt gammas (PG). PG emission along the pen...

Dosimetric Characterization of Sun Nuclear EDGE Diodes in the Plateau Region of Proton Pencil Beam Scanning (PBS) Fields

Authors: Wesley S. Culberson, Ryan Gardner, Patrick M Hill, Mark Pankuch, Karsten K. Wake

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Northwestern Medicine Proton Center

Abstract Preview: Purpose: To assess the dosimetric capabilities of Sun Nuclear (Melbourne, FL) EDGE Diode Detectors™ for measurements in the plateau region of pencil beam scanning (PBS) fields. Many clinical dosimeter...

Dosimetric Evaluation of Radiation Treatment Planning Algorithms in IMRT and VMAT Techniques: Analysis with Central and Peripheral Lung Tumors

Authors: Sumanta Manna, Atul Mishra, Surendra Prasad Mishra, Kailash Kumar Mittal, Anoop Kumar Srivastava, Neha Yadav

Affiliation: Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Department of radiation Oncology, Apollomedics Super Speciality Hospitals, Department of Radiation Oncology, Uttar Pradesh University of Medical Sciences, Department of Radiation Oncology, Kalyan Singh Super Specialty Cancer Institute

Abstract Preview: Purpose: This study aimed to assess the dosimetric performance of Volumetric Modulated Arc Therapy (VMAT), step-and-shoot Intensity-Modulated Radiation Therapy (ss-IMRT), and dynamic Intensity-Modulat...

Dosimetric Validation and Algorithmic Limitations of Pencil Beam Scanning Proton Therapy for Thin Chest-Wall Treatments

Authors: J Isabelle Choi, Meng Wei Ho, Isabel Lin, Hang Qi, Qi Zeng, Ajay Zheng

Affiliation: New York Proton Center, Scarsdale High School

Abstract Preview: Purpose: Proton therapy is a promising treatment modality for breast cancer due to its unique dosimetric advantage. Accurate dose calculation is critical to ensure effective treatment outcomes. The fo...

Dosimetry Comparison of Surface-Guided and Orthogonal X-Ray Film-Based Setups for Proton Pencil-Beam Scanning in Breast Cancer Treatment

Authors: Darren Kaplan, Chenguang Liu, Mark Pankuch

Affiliation: Northwestern Medicine Proton Center

Abstract Preview: Purpose: This study evaluates the hypothesis that surface-guided radiation therapy for the breast or chest wall using proton PBS provides comparable target coverage and OARs sparing to x-ray-based IGR...

Enhancement of Adaptive Collimation Precision on Pencil Beam Scanning Proton System

Authors: Akbar Anvari, Carnell J. Hampton, Melanie R. Piantino, Kai Yang

Affiliation: Levine Cancer Institute, Atrium Health

Abstract Preview: Purpose: To evaluate aperture collimation on a C-shape gantry-mounted proton accelerator. Mevion S250i Hyper scanning machine implemented aperture collimation utilizing adaptive aperture (AA). The AA ...

Enhancing Dosimetric Conformity in Single-Energy Bragg Peak Flash Therapy Using Aperture-Based Techniqu

Authors: Chin-Cheng Chen, Chingyun Cheng, Longfei Diao, Benjamin Durkee, Minglei Kang, Haibo Lin, LeLe Liu, Yangguang Ma, Xuanqin Mou, YunTong Pei, Charles B. Simone, YuFei Wang, Xueqing Yan, Xingyi Zhao, Wang Zhengda

Affiliation: Peking University, St. Jude Children's Research Hospital, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, School of Software Engineering, Xi’an Jiaotong University, School of information and communications engineering, Faculty of electronic and information engineering, Xi’an Jiaotong University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: This study evaluates the effectiveness of apertures in improving lateral dose falloff in proton pencil beam scanning (PBS) single-energy Bragg peak (SEBP) FLASH radiotherapy (RT). The approac...

Evaluating Discrete Proton Arcs Converted to Pencil Beam Scanning Plans for Glioma and Chordoma in Raystation with a Mevion s250i Hyperscan Proton Therapy System

Authors: Mark A. Newpower, Jill Taylor

Affiliation: University of Oklahoma Health Sciences Center

Abstract Preview: Purpose: RayStation 2024A allows planners to optimize intensity modulated proton therapy (IMPT) plans using discrete arcs which can then be converted to traditional pencil beam scanning (PBS) beams fo...

Evaluating the Impact of Beam Spot Spacing on Dose Rates and Field Uniformity for Small Animal Proton Ultra-High Dose Rate Irradiation

Authors: Jack Biondo, Audrey Magness, Anthony E. Mascia, Zhiyan Xiao, Yongbin Zhang

Affiliation: Cincinnati Children's Proton Therapy Center

Abstract Preview: Purpose: Proton FLASH-RT has shown promise reducing normal tissue toxicity while maintaining tumor control. However, in vivo experiments critically depend on achieving ultra-high dose rate (UHDR) and ...

Evaluating the Impact of Spot Spacing on Dosimetric Outcomes in Dynamic Arc Proton Therapy for Prostate SBRT

Authors: Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Umesh Rana, Hina Saeed, Nishan Shrestha, Somol Sunny

Affiliation: Florida Atlantic University, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: DynamicARC is a novel pencil beam scanning (PBS) proton therapy technique with the potential to provide more conformal dose distributions and reduce treatment time. This study investigates th...

Evaluation of Dose-Rate Metrics in Intensity Modulated Proton Therapy for Prostate Cancer Treatments

Authors: Stella Flampouri, Edgar Gelover, William Andrew LePain, Roelf L. Slopsema, Alexander Stanforth, Mingyao Zhu

Affiliation: Emory Healthcare, Emory University

Abstract Preview: Purpose: Little consideration was given to the change in dose rate (DR) observed when moving to pencil beam scanning (PBS). This study reports on DR in clinical prostate PBS plans. While dose distribu...

Evaluation of Fast Monte Carlo Secondary Dose Calculation for Intensity Modulated Proton Therapy in Heterogeneous Materials

Authors: Ergun E. Ahunbay, Abdul Kareem Parchur, Eric S. Paulson, Ilaria Rinaldi, Angelo Schiavi, Li Zhao

Affiliation: Sapienza University of Rome, Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Secondary dose calculations (SDC) facilitate patient-specific quality assurance for online adaptive intensity-modulated proton therapy (IMPT). However, there is currently a lack of commercial...

Evaluation of Four Different Dose Calculation Algorithms for Commissioning of a New Tyoe of Scanned Proton Therapy System

Authors: Nobukazu Fuwa, Masato Horita, Takahiro Kato, Ryo Tanokura, Yuki Tominaga

Affiliation: Medical Co. Hakuhokai, Osaka Proton Therapy Clinic, Central Japan International Medical Center, Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University

Abstract Preview: Purpose:
We have installed a new type of scanned proton therapy system (Varian ProBeam 360°TM). This study aimed to evaluate the four different dose calculation algorithms.
Methods:
Sixteen b...

Feasibility Study of Single Gantry Angle Proton Minibeam Lattice Radiotherapy

Authors: Anthony Hong Cheol Lim, Rayyan L Mahmood, Alexander Stanforth, Chris C. Wang, Mingyao Zhu

Affiliation: Georgia Institute of Technology, Emory University

Abstract Preview: Purpose: The purpose of this project is to test the feasibility of proton minibeam lattice radiotherapy within an existing clinical setting.
Methods:
The TOPAS code is used to model a scenario i...

Feasibility of Commercial Independent-Dose-Calculation for Pencil-Beam-Scanning Proton Therapy

Authors: Wen C. Hsi, Kayla Schneider

Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiation Oncology, University of Arkansas for Medical Sciences

Abstract Preview: Purpose:
Measurement-based patient-specific quality-assurance (PSQA) conducted with a 2D dosimeter to verify delivered dose of each field over 3 measurement-depths is time-consuming with limited se...

Feasibility of Producing GRID Therapy Dosimetry Using a Compact Linac Treatment Head with Pencil Beam Scanning

Authors: Yiran Liu, Zhengzheng Liu, Fang-Fang Yin

Affiliation: Duke Kunshan Univeristy, Huazhong University of Science and Technology, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: To investigate the feasibility of producing high dose rate GRID therapy using a compact linear accelerator (LINAC) treatment head with scanning beam and stationary grid collimator.
Methods...

Free-Breathing Spirometer-Gated Proton Pencil Beam Scanning Delivery Maintains Tumor Coverage with Improved Organ-at-Risk Sparing: A Motion Phantom Validation

Authors: Uriel Aura, Qing Chen, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Meng Wei Ho, Sheng Huang, Minglei Kang, Stanislav Lazarev, Nancy Y Lee, Yang Lei, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Anna Zhai, Ajay Zheng

Affiliation: DYN'R Medical System, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Tianjin Medical University Cancer Institute&Hospital, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: Managing tumor motion during pencil beam scanning proton therapy remains challenging. This study investigated the feasibility and dosimetric benefits of Free-Breathing Respiratory-Gated Deliv...

Improvements from Monte Carlo Simulations over Pencil Beam Algorithms for Normal Tissue Dose Reconstruction in Proton Therapy Patients

Authors: Amy Berrington de Gonzalez, Keith T Griffin, Jae Won Jung, Cari M Kitahara, Choonik Lee, Choonsik Lee, Aimee L McNamara, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock

Affiliation: University of Michigan, East Carolina University, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School, Institute of Cancer Research

Abstract Preview: Purpose: Radiotherapy dose reconstruction enables retrospective epidemiological studies that connect late health effects to the organ-absorbed radiation doses received during treatment. Though clinica...

Improving Output Stability with Angular Correction Factor on Pencil Beam Scanning Proton System

Authors: Akbar Anvari, Carnell J. Hampton, Melanie R. Piantino, Kai Yang

Affiliation: Levine Cancer Institute, Atrium Health

Abstract Preview: Purpose: To evaluate the effectiveness of angular correction factor for output stability on Mevion S250i Hyper scanning machine, which allows user to apply correction factors for output at selected ga...

Log-Based Predictive Modeling of the Dynamic Collimation System (DCS) Trimmer Dynamics for Efficient Proton Pbs Delivery

Authors: Wesley S. Culberson, Albert Du, Ryan T. Flynn, Ryan Gardner, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Eric Jensen, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake

Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Ion Beam Applications (IBA), University of Iowa, Iowa Health Care

Abstract Preview: Purpose: To develop an accurate predictive temporal model for the movement of Dynamic Collimation System (DCS) trimmers during collimated proton pencil beam scanning (PBS) deliveries using log data. T...

Maximum Conformity IMPT Planning with the Dynamic Collimation System

Authors: Wesley S. Culberson, Albert Du, Ryan T. Flynn, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake

Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Iowa, Iowa Health Care

Abstract Preview: Purpose:
To perform end-to-end treatment planning and delivery verification of energy-specific collimated treatments optimized to achieve the maximum obtainable high-dose conformity using the dynam...

Multi-Center Evaluation of an AI Beam Angle Prediction Model for Liver Treatments Using Pencil Beam Scanning Proton Therapy

Authors: Christopher Ackerman, Chang Chang, Yan-Cheng Huang, Robert Kaderka, Che Lin, Hsin-Chih Lo, Iain MacEwan, Yi-Chin Tu, James Urbanic

Affiliation: University of California San DIego, Taiwan AI Labs, National Taiwan University, California Protons Cancer Therapy Center, University of Miami, Sylvester Comprehensive Cancer Center

Abstract Preview: Purpose: To investigate the performance of an existing AI beam angle prediction model on external patient datasets for liver proton treatments. The AI model was trained on datasets exclusively from on...

Neutron Dose Measurements with Multiple Dosimetry Techniques for Fetal Dose Estimation

Authors: Ahmet S. Ayan, Estelle Batin, Austin M. Faught, Peter E. Klages, Eunsin Lee, Collin Nappi, Mina Okello, Meghana Ramani, Zachary X. Richards, Parisa Sadeghi

Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The Ohio State University Wexner Medical Center, Ohio State University, The Ohio State University

Abstract Preview: Purpose: Neutron doses are not modelled in proton treatment planning systems, so measurements were taken with two independent dosimeter types to quantify representative neutron fetal doses in pencil b...

Physics-Informed Neural Network for In Vivo Dosimetry during Proton Therapy Using Protoacoustic Tomography

Authors: Kristina Bjegovic, Yong Chen, Gilberto Gonzalez, Yankun Lang, Lei Ren, Leshan Sun, Liangzhong Xiang, Yifei Xu

Affiliation: University of Maryland School of Medicine, University of California, Irvine, University of Oklahoma Health Sciences Center, University of Oklahoma Health Science Center

Abstract Preview: Purpose: Proton therapy is becoming an increasingly popular choice for cancer treatment due to its precision, reduced side effects, and effectiveness. While dosimetry is fundamental to the success of ...

Population Level Robustness Evaluation for Establishment of Benchmarks for Optimized Plans for Prostate Proton Therapy

Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey, Taylor Ransom

Affiliation: Thompson Proton Center, University of Tennessee

Abstract Preview: Purpose: Proton pencil beam scanning can reduce normal tissue dose but is highly sensitive to setup, anatomical changes, and range variations. These uncertainties may compromise target coverage and or...

Proton Pencil Beam Scanning Ultra-High Dose Rate 3D Lattice Radiotherapy: A Proof-of-Concept Flash Sfrt Study

Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng

Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...

Single Plane Positioning Tracking Proton and Helium Pencil Beam Radiographs: Phantom Study

Authors: Anahita Bakhtiari Moghaddam, Don F. DeJongh, Ethan DeJongh, Jennifer Hardt, Oliver Jäkel, Lukas Martin, Alexander Pryanichnikov, Joao Seco, Christina Stengl, Niklas Wahl

Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), ProtonVDA LLC, Department of Physics and Astronomy, Heidelberg University, Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT)

Abstract Preview: Purpose:
To evaluate the feasibility and performance of single-plane position tracking for proton and helium pencil beam radiography using a prototype imaging system, with the goal of providing a c...

The Biological TCP/NTCP Modelling on Oropharyngeal Head-and-Neck Cancer for Patients Treated with Proton Beam Therapy

Authors: Wen C. Hsi, Tae Kyu Lee, Biniam Yo Tesfamicael

Affiliation: Allina Health, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Oklahoma Proton Center

Abstract Preview: Purpose: When minimal dose-variations induced by inter-fractional anatomical-changes and positioning-deviation were found for having limited impact on clinic-outcomes of oropharyngeal head-and-neck (H...

The CT Calibration for Proton Pencil Beams System

Authors: Xiangli Cui, Wanli Huo, Jie Li, Lingling Liu, Tao Ma, Yuanyuan Wang

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Ion Medical Center, Hefei Cancer Hospital, Chinese Academy of Sciences, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University

Abstract Preview: Purpose: In practice, treatment planning systems (TPS) of proton therapy require a CT calibration curve, which relates Hounsfield units (HU) to relative stopping power (RSP). Single-energy CT as a sta...

The Dosimetric and Dose RATE Characteristics for Bragg Peak Proton MINI-Ridge Filter Flash in Comparison to Conventional Proton and Filter Free Flash for Breast and Prostate

Authors: Jenghwa Chang, Chingyun Cheng, J Isabelle Choi, Muhammad Hamza, Minglei Kang, Tyler Kaulfers, Grant Lattery, Haibo Lin, Charles B. Simone, Xingyi Zhao

Affiliation: Peking University, Hofstra University Medical Physics Program, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Physics and Astronomy, Hofstra University, Physics Resident at Montefiore Einstein, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: In terms of high dose rate FLASH, the question remains on how to properly deliver treatment and what clinical sites are feasible to deliver such treatment. The novel Bragg peak (BP-FLASH) and...

Two Radiochemical Monte Carlo Models to Investigate the Radical Yields Under Proton Flash Irradiations

Authors: Yujie Chi, Yao Hao, Xun Jia, Youfang Lai, Yuting Peng, Francisco Javier Reynoso, Lingshu Yin, Tianyu Zhao, Xiandong Zhao

Affiliation: Johns Hopkins University, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Physics, University of Texas at Arlington, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, University of South Florida

Abstract Preview: Purpose: FLASH radiation therapy has shown remarkable tissue sparing effects compared to radiation therapy at conventional dose rates (CDR). Yet, its mechanism remains unclear. Radical production modu...

Ultrafast Proton Delivery with Pin Ridge Filters (pRFs): A Novel Approach for Motion Management in Proton Therapy

Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Yinan Wang, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou

Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: Active breath-hold techniques effectively mitigate respiratory motion but poses challenges for patients who are unable to tolerate the procedure. Conventional planning relies on multiple ener...