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Results for "psma spect": 8 found

A Practical Experimental Software Validation Method for Voxel-Based Personalised Dosimetry in Radiopharmaceutical Therapy

Authors: Thomas Gee, Sofia Michopoulou, Amit Nautiyal

Affiliation: University Hospital Southampton

Abstract Preview: Purpose: Dosimetry software that is accessible to departments offers new opportunities to improve patient-specific dosimetry. Prior to clinical decision-making, it is essential to validate dosimetry s...

Commissioning, Validation and Pilot Study of New Rpld System for Dosimetry Audits in Bulgaria

Authors: Gueorgui Gueorguiev, Katia Sergieva, Filip Simeonov, Tsvetelina Todorova, Bozhidar Vladimirov

Affiliation: National Centre of Radiobiology and Radiation Protection, Queen Giovanna University Hospital

Abstract Preview: Purpose: Dosimetry audit is an essential tool enhancing confidence in the accuracy of treatment delivery and in prevention of radiation treatment incidents. Current work depicts how novel nationwide r...

Evaluating 177Lu-PSMA-I&t Reconstruction Parameter Influences on Image Quality and Quantification

Authors: Martin Auerbach, Jeremie Calais, Johannes Czernin, Magnus Dahlbom, Zachary Ells, Adrien Holzgreve, Koichiro Kimura, Karam Masri, Catherine (Caffi) Meyer, David Sennung

Affiliation: Department of Nuclear Medicine, UCLA, UCLA, University of California, Los Angeles

Abstract Preview: Purpose: Lutetium-177 PSMA SPECT/CT imaging offers the possibility of qualitative image analysis for tumor response assessment and quantitative image analysis for individualized dosimetry. However, th...

Lu-PSMA-Dose, a French Retrospective Multicentric Dosimetry Study of 177Lu-PSMA Treatments for Metastatic Castration-Resistant Prostate Cancer

Authors: NadÚge Anizan, Jean-Noël Badel, Thomas Baudier, David Broggio, Désirée Deandreis, Ludovic Ferrer, Didier Franck, Camilo Garcia, Jean Gasteuil, Anne-Laure Giraudet, Olivier Humbert, Laetitia Imbert, Malick Koulibaly, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard, Caroline Rousseau, Guido Rovera, David Sarrut, Paul Schwartz, Nicolas Varmenot

Affiliation: Institut de CancĂ©rologie de l’Ouest, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de Physique MĂ©dicale, Institut BergoniĂ©, Service de Physique MĂ©dicale, CHRU de Nancy Brabois, Service de MĂ©decine NuclĂ©aire, Centre de lutte contre le cancer LĂ©on BĂ©rard, UniversitĂ© de Lyon, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, UniversitĂ© Nice CĂŽte d’Azur, Centre Antoine Lacassagne, Service de MĂ©decine NuclĂ©aire, Gustave Roussy, Service de MĂ©decine NuclĂ©aire, Institut de CancĂ©rologie de l’Ouest, Service de Physique MĂ©dicale, Service de MĂ©decine NuclĂ©aire, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, AutoritĂ© de SĂ»retĂ© NuclĂ©aire et de Radioprotection (ASNR), PSE-SANTE/SDOS, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon, CREATIS CNRS UMR 5220; INSERM U 1044; UniversitĂ© de Lyon; INSA‑Lyon; Centre de lutte contre le cancer LĂ©on BĂ©rard, Institut BergoniĂ©, Service de MĂ©decine NuclĂ©aire

Abstract Preview: Purpose: The main objective of the Lu-PSMA-Dose study, sponsored by ASNR, is to estimate retrospectively the individual absorbed dose delivered to patients treated with 177Lu-PSMA for metastatic castr...

Personalized Dosimetric Workflow for 177Lu-PSMA Treatments Considering the Cross-Irradiation from Bone Metastases to Red Bone Marrow

Authors: NadÚge Anizan, David Broggio, Désirée Deandreis, Didier Franck, Camilo Garcia, Stéphanie Lamart, Sébastien Leygnac, Alexandre Pignard

Affiliation: Gustave Roussy, Service de Physique Médicale, Institut Bergonié, Service de Physique Médicale, Gustave Roussy, Service de Médecine Nucléaire, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSE-SANTE/SDOS/LEDI, Autorité de Sûreté Nucléaire et de Radioprotection (ASNR), PSE-SANTE/SDOS

Abstract Preview: Purpose: This work aimed at developing an innovative workflow for 177Lu-PSMA personalized dosimetry to lesions and organs at risk (OAR) simultaneously, considering the cross-irradiation from bone meta...

Poisson Decay in Pharmacokinetics with Imaging in Targeted Alpha Therapy

Authors: Lars R Furenlid, Chiao Huang, Matthew A. Kupinski, Brian W. Miller

Affiliation: University of Arizona, Departments of Radiation Oncology and Medical Imaging, University of Arizona

Abstract Preview: Purpose: To sample random numbers of decay of radiotracers in a pharmacokinetic compartment model for Monte-Carlo simulation of imaging in targeted alpha therapy.
Methods: Time-activity curves (TAC...

SPECT/CT Multimodal Segmentation of Bone Marrow for Theranostic Dosimetry

Authors: Tommaso Frigerio, Joshua Genender, John M. Hoffman, Catherine (Caffi) Meyer

Affiliation: UCLA, David Geffen School of Medicine at UCLA

Abstract Preview: Purpose: Accurate bone marrow segmentation is required for bone marrow dosimetry to monitor for dangers in PSMA-Lu177 radioligand therapy. We introduce a hybrid (AI/semantic knowledge) segmentation pi...

Using Multi-Peak Reconstructions for Dosimetry of Fast and Quantitative Lutetium-177 SPECT/CT

Authors: Julia Brosch-Lenz, Munir Ghesani, Francesc Massanes, Michael Morris, Babak Saboury, Eliot Siegel, Alexander Hans Vija

Affiliation: Institute of Nuclear Medicine, Siemens Medical Solutions USA Inc., Molecular Imaging

Abstract Preview: Purpose: Quantitative imaging of the radiopharmaceutical distribution is crucial for treatment evaluation and dosimetry. However, as patient numbers for Lutetium-177-(177Lu)-labelled therapies continu...