Authors: Sixue Dong, Weigang Hu, Jiazhou Wang, Zhen Zhang
Affiliation: Fudan University Shanghai Cancer Center
Abstract Preview: Purpose: This study aimed to evaluate the dosimetric benefits and treatment efficiency of different beam configurations in 4π non-coplanar VMAT for SBRT in recurrent head and neck tumors
Method...
Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Beatriz Guevara, Lauren E Henke, Angela Jia, Rojano Kashani, Kyle O'Carroll, Alex T. Price, Adithya Reddy, Atefeh Rezaei, Daniel E Spratt, Runyon C. Woods
Affiliation: University Hospitals Seidman Cancer Center
Abstract Preview: Purpose: To evaluate the effect of unedited AI-generated contours used for online adaptive radiotherapy (FLOW-ART) on the plan quality of prostate treatments as compared to non-adaptive (non-ART) proc...
Authors: Drexell Hunter Boggs, Carlos E. Cardenas, Allison Dalton, John B Fiveash, Joel A. Pogue, Richard A. Popple, Farnaz Rahim Li
Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham
Abstract Preview: Purpose: External-beam Accelerated Partial Breast Irradiation (APBI) using stereotactic-body radiotherapy (SBRT) is increasingly adopted as an alternative to whole-breast radiation, offering targeted ...
Authors: Ramesh Boggula, Lincoln Houghton
Affiliation: Karmanos Cancer Institute, Wayne State University
Abstract Preview: Purpose: To evaluate an approach that selectively applies adaptive re-planning only when needed to reduce clinical workload while maintaining treatment quality. Daily adaptive radiotherapy (ART) has t...
Authors: Edward D. Brandner, Weihua Fu, M. Saiful Huq, Ronald John Lalonde, Kiran Mehta, Hima Bindu Musunuru, Yongqian Zhang
Affiliation: UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman CancerCenter
Abstract Preview: Purpose: Treatment of diffuse and extensive involvement of the skull by malignancy presents a difficult challenge for radiation therapy. This study reports preliminary experience of a modified volumet...
Authors: Chuan He, Anh H. Le, Iris Z. Wang
Affiliation: Roswell Park Comprehensive Cancer Center, Cedars-Sinai
Abstract Preview: Purpose: To develop a non-measured and DVH-based (NMDB) IMRT QA framework integrating machine learning (ML) to classify lung SBRT VMAT plans prone to delivery errors
Methods: 560 Eclipse AcurosXB l...
Authors: Charmainne Cruje, Maria Dumol, Nawroz Fatima, Marisa Finlay, Kalaina Johnson, Raman Mohla, Jasleen Uppal
Affiliation: Trillium Health Partners, Carlo Fidani Regional Cancer Centre
Abstract Preview: Purpose: To evaluate the robustness of a breast SBRT protocol in achieving target coverage by utilizing online- and retrospectively-matched CBCT-to-CT images.
Methods: The first pilot patient was s...
Authors: Josephine Chen, CheukKai Becket Hui, Yildirim D. Mutaf
Affiliation: Kaiser Permanente
Abstract Preview: Purpose:
To demonstrate the effectiveness of a target clustering program in generating cluster configurations and isocenter placements for multiple brain lesions in SRS treatment planning, with the...
Authors: Lu Jiang, Shusen Jing, Qihui Lyu, Dan Ruan, Ke Sheng, Qifan Xu
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose: In radiotherapy, the conformity and compactness of dose distribution are vital to patient outcomes. The introduction of highly complex planning, such as 4π radiotherapy, has provided a system...
Authors: Steve Braunstein, Angela Jakary, Hui Lin, Bo Liu, Janine Lupo, Tiffany Ngan, Ke Sheng, Nate Tran
Affiliation: Radiation Oncology, University of California San Francisco, Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, Department of Radiation Oncology, University of California San Francisco, Department of Radiology and Biomedical Imaging, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose: Current RT clinical target volumes (CTVs) for Glioblastoma (GBM) employ 2cm isotropic expansions of gross tumor volumes. However, studies showed patients still experience progression beyond t...
Authors: Yabo Fu, Yang Lei, Yu Lei, Haibo Lin, Ruirui Liu, Tian Liu, Kenneth Rosenzweig, Charles B. Simone, Shouyi Wei, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York Proton Center
Abstract Preview: Purpose: Beam orientation optimization (BOO) in intensity-modulated radiation therapy (IMRT) is traditionally a complex, non-convex problem tackled with heuristic methods. This study benchmarks global...
Authors: Andrew Huang, Jonathan Huang, Andrew S Kennedy, Ellie Grace Kong, Ajay Zheng
Affiliation: New York Proton Center, Centennial Medical Center, Executive Medical Physics Associates, Sarah Cannon Cancer Institute, Belmont University
Abstract Preview: Purpose:
Lung stereotactic body radiotherapy (SBRT) is the standard of care for early-stage lung cancer. Respiratory phase gating can be applied to mitigate motion-induced effects. The purpose of t...
Authors: Eduardo Florian, Hiram Gay, Geoffrey D. Hugo, Otto Hurtarte, Milton Ixquiac, Erick Orlando Montenegro, Franky Eduardo Reyes, Francisco Javier Reynoso, Edgar Aparicio Ruiz, Baozhou Sun, Jacaranda Van Rheenen, Kevin Vega, Angel Velarde, Vicky de Falla
Affiliation: WashU Medicine, Liga Nacional Contra el Cancer, Liga Nacional Contra el Cancer/INCAN, Liga Nacional Contra el Cancer / INCAN, Liga Nacional Contra el Cancer and Universidad de San Carlos de Guatemala, Washington Univ. in St. Louis, Liga Nacional Contra el Cáncer / INCAN, Washington University in St. Louis, Varian, Baylor College of Medicine
Abstract Preview: Purpose:
IMRT has become the standard of care in high-income countries (HICs) due to reduced toxicity and improved treatment outcomes.
The purpose of this work is validating the KBP model shared...
Authors: Lei Dong, Yin Gao, Taoran Li, Michael Salerno, Boon-Keng Kevin Teo, Melissa Vila
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: A novel solution, RapidArc Dynamic-RAD (Varian Medical Systems, Palo Alto, USA) has been implemented to integrate VMAT with modulation of IMRT-like static-angle ports, including use of a dyna...
Authors: Kai-Cheng Chuang, Oana I. Craciunescu, Christopher Kelsey, Joseph Kowalski, Nicole Larrier, Xinyi Li, Sheridan G. Meltsner, Anna E. Rodrigues, Yang Sheng, Qiuwen Wu
Affiliation: Duke University, Duke University Medical Center
Abstract Preview: Purpose: To clinically implement a Volumetric Modulated Arc Therapy (VMAT) procedure for Total Body Irradiation (TBI) with off-the-shelf tools.
Methods: Patient is treated on linac couch with a hyb...
Authors: Theodore Higgins Arsenault, Beatriz Guevara, Rojano Kashani, Raymond F. Muzic, Gisele Castro Pereira, Alex T. Price
Affiliation: University Hospitals Seidman Cancer Center, Case Western Reserve University Department of Biomedical Engineering
Abstract Preview: Purpose: Accurate dose prediction in radiotherapy is essential for treatment planning. This study evaluates four nnUnet-based models using the OpenKBP head and neck dataset: a baseline model (Model 1)...
Authors: Gourav Jhanwar, Mojtaba Tefagh, Masoud Zarepisheh
Affiliation: The University of Edinburgh, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose:
Radiotherapy treatment planning involves solving computationally-intensive and time-consuming optimization problems. Central to these problems is a large matrix known as the dose-influence...
Authors: Baher Elgohari, M. Saiful Huq, Ronald John Lalonde, Fang Li, Noor Mail, Jeonghoon Park, Tyler Wilhite
Affiliation: UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, UPMC Hillman Cancer Center, UPMC, Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose:
To compare toxicity between consecutive-daily (QD) with every-other-day (QoD) delivery of lung stereotactic-body-radiation (SBRT) for central non-small-cell lung cancer (NSCLC).
Methods...
Authors: Yaspal Badyal, Rabten Datsang, Tianjun Ma, William Song
Affiliation: MVision AI, Virginia Commonwealth University
Abstract Preview: Purpose: Deep learning (DL)-based dose distribution predictions for prostate cancer show significant potential for OAR sparing compared to manually optimized treatment plans. We aim to generate clinic...
Authors: Mingli Chen, Huan Amanda Liu, Weiguo Lu, Lin Ma
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Mayo Clinic
Abstract Preview: Purpose: To reduce the back-and-forth in planning process between physicians and dosimetrists resulting from trade-off exploration, we proposed a novel deep learning framework called DeepTuning.
Me...
Authors: Michael Burke, David J. Carlson, Yiu-Hsin Chang, Huixiao Chen, Zhe (Jay) Chen, Emily A. Draeger, Dae Yup Han, Vanessa Hill, Ann-Teresa Jasman, John Kim, Svetlana Kuznetsova, MinYoung Lee, Daniel Longo, Henry S. Park, Adam Shulman, Lauren Tressel, Weili Zhong
Affiliation: Department of Therapeutic Radiology, Yale University School of Medicine
Abstract Preview: Purpose:
The complexity of biology-guided radiotherapy (BgRT), particularly with systems like RefleXion X1, necessitates robust pre-treatment quality assurance (QA) to ensure patient safety, treatm...
Authors: Chase Cochran, Damodar Pokhrel, William St Clair
Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine
Abstract Preview: Purpose: Currently, intraocular disease is primarily treated via COMS-plaques brachytherapy. Various stereotactic approaches via photons/proton beam have also been implemented (CyberKnife/GammaKnife/p...
Authors: Kaelyn Becker, Xenia Ray
Affiliation: University of California, San Diego, University of California San Diego
Abstract Preview: Purpose: Ethos 2.0 with HyperSight (Varian Medical Systems) imaging enables nearly fully automated offline adaptive radiotherapy including automated deformation of targets and recalculation on the Hou...
Authors: Ming Chao, Hao Guo, Tenzin Kunkyab, Yang Lei, Tian Liu, Kenneth Rosenzweig, Robert Samstein, Junyi Xia, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai
Abstract Preview: Purpose:
This study aims to develop and validate an Eclipse Scripting Application Programming Interface (ESAPI)-based planning toolbox that incorporates preset human expertise to improve planning e...
Authors: Michael Buckstein, Yang Lei, Tian Liu, Charlotte Elizabeth Read, Jing Wang, Kaida Yang, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai
Abstract Preview: Purpose: Inter-fraction anatomic variations in liver SBRT can cause significant discrepancies between planned and delivered doses. We developed a CBCT-based accumulative algorithm to directly compare ...
Authors: Xiance Jin
Affiliation: 1st Affiliated Hospital of Wenzhou Medical University
Abstract Preview: Purpose:
Deep learning deformable registration models was proposed to predict optimal dose distributions a with a few of optimal planned doses using a few-shot learning for cervical cancer.
Meth...
Authors: Yi Li
Affiliation: Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University
Abstract Preview: Purpose: Advances in radiotherapy technology are crucial for improving cervical cancer (CC) treatment. This study explores a novel X-ray and γ-ray dual-modality radiation (TaiChiB) system, comparing i...
Authors: Alyssa Gadsby, William J. Godwin, Jennifer L. Harper, Daniel G. McDonald, Jean L. Peng, Alek K. Rapchak, Sean A Roles, Austin M. Skinner, Stephanie Tan
Affiliation: Medical University of South Carolina
Abstract Preview: Purpose: Multi-Criteria Optimization (MCO) theoretically allows for increased dose control during optimization. This study is the first to compare standard optimization (SO) and MCO for accelerated pa...
Authors: Aliasghar Rohani, Rui Zhang
Affiliation: Louisiana State University, Baton Rouge, Louisiana, Department of Radiation Oncology, Mary Bird Perkins Cancer Center
Abstract Preview: Purpose: This study aimed to evaluate the impact of simultaneous optimization of multi-photon beam energy and fluence on IMRT and VMAT treatment planning.
Methods: An Elekta linear accelerator (lin...
Authors: Awens Alphonse, Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Tino Romaguera, Hina Saeed, Nishan Shrestha, Somol Sunny
Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida
Abstract Preview: Purpose: Prostate stereotactic body radiation therapy (SBRT) requires precise dose delivery to the target volume and organ-at-risk (OAR) sparing. This study compares MR-Linac (MRL) and CyberKnife (CK)...
Authors: Awens Alphonse, Nebi Demez, Noufal Manthala Padannayil, Haley Park, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Nishan Shrestha, Somol Sunny
Affiliation: Florida Atlantic University, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida
Abstract Preview: Purpose: This study evaluates the dosimetric effects of patient positioning errors, including setup inaccuracies and yaw deviations, on dual-isocenter volumetric modulated arc therapy (VMAT) plans for...
Authors: Sumanta Manna, Atul Mishra, Surendra Prasad Mishra, Kailash Kumar Mittal, Anoop Kumar Srivastava, Neha Yadav
Affiliation: Department of Radiation Oncology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Department of radiation Oncology, Apollomedics Super Speciality Hospitals, Department of Radiation Oncology, Uttar Pradesh University of Medical Sciences, Department of Radiation Oncology, Kalyan Singh Super Specialty Cancer Institute
Abstract Preview: Purpose: This study aimed to assess the dosimetric performance of Volumetric Modulated Arc Therapy (VMAT), step-and-shoot Intensity-Modulated Radiation Therapy (ss-IMRT), and dynamic Intensity-Modulat...
Authors: Megan E. Daly, Ryan D. Hernandez, Abriel J. Horak, Soo Kyoung Kim, Peter C. Park, Dwaine O. Spence, Payton H. Stone, Cari L. Wright
Affiliation: UC Davis Cancer Center
Abstract Preview: Purpose: To evaluate a fallback planning workflow used for cross-modality treatment planning and delivery between helical Tomotherapy and volumetric modulated arc therapy (VMAT) using conventional L-s...
Authors: Abby E. Besemer, Carolyn Eckrich, John M. Floberg, Michael J. Lawless, Jessica R. Miller, Joseph B. Schulz, Jordan M. Slagowski, Autumn E. Walter-Denzin
Affiliation: University of Wisconsin-Madison Department of Medical Physics, University of Wisconsin-Madison Department of Human Oncology, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, Stanford University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: The aim of this treatment planning study was to evaluate the feasibility of escalating dose with HDR prostate brachytherapy to imaging-identified intraprostatic macroscopic lesions while mode...
Authors: Makunda Aryal, Gregory Bartlett, David D. Campos, Ke Colin Huang, Sook Kien Ng, Christopher F. Njeh, Oluwaseyi Oderinde, Edwin Quashie, Ashok Tiwari, Yong Yue
Affiliation: Purdue University, Department of Radiation Oncology, Indiana University, Indiana University, Indiana University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose:
Linear accelerator-based single-isocenter Stereotactic Radiosurgery (SRS) is widely used for treating brain metastases due to its efficiency, reduced treatment time, and lower imaging dose...
Authors: Matthew Stephen Andriotty, Chi Ma, Xiao Wang, Keying (Karen) Xu, Suhong Yu, Ning J. Yue, Yin Zhang
Affiliation: Brigham and Women's Hospital, Rutgers Cancer Institute of New Jersey
Abstract Preview: Purpose: To evaluate the effects of overlapping CT reconstruction on dosimetry calculation for LINAC-based SRS patients simulated on CT simulators from three different vendors.
Methods: CT simulati...
Authors: Dharmin D. Desai, Ellis Lee Johnson, Philip J. Kallenberg, Kapil M. Mishra
Affiliation: Spectrum Medical Physics, University of Kentucky, Varian Advanced Oncology Solutions
Abstract Preview: Purpose: The “Ask For It” (AFI) manual optimization strategy has been shown to generate high quality SRS plans within Eclipse. The purpose of this work is to directly compare manually generated Eclips...
Authors: Sean P. Boyer, Shae Gans, Mingcheng Gao, Draik B. Hecksel, Mark Pankuch
Affiliation: Northwestern Medicine Proton Center, Northwestern Medicine Chicago Proton Center
Abstract Preview: Purpose: Protons deposit a large portion of their energy at the end of their range in a region known as the Bragg peak, which may increase the relative biological effective (RBE) dose in this region. ...
Authors: Prasanna Alluri, Mona Arbab, Xingzhe Li, Chang-Shiun Lin, Mu-han Lin, David D.M. Parsons, Asal Rahimi, Justin D. Visak, Narine Wandrey
Affiliation: UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX
Abstract Preview: Purpose: Intelligence-Optimization-Engine (IOE) v1.0 relied heavily on planner expertise and patient-specific IMRT beam arrangements, requiring frequent revisions. While VMAT workflows offered potenti...
Authors: Rita Buono, Elisabetta Cagni, Roberta Castriconi, Surendra Bahadur Chand, Marco Esposito, Claudio Fiorino, Valeria Landoni, Aldo Mazzilli, Eugenia Moretti, Lorenzo Placidi, Giulia Rambaldi Guidasci, Alessia Tudda
Affiliation: IRCCS San Raffaele Scientific Institute, Department of Advanced Technology, IRCCS Regina Elena National Cancer Institute, ASU FC Medical Physics, University Hospital of Parma AOUP, ICTP, B.P. Koirala Memorial Cancer Hospital, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Fatebenefratelli Isola Tiberina – Gemelli Isola
Abstract Preview: Purpose: To explore the feasibility and educational impact of transferring knowledge-based planning (KBP) models—developed using Italian breast radiotherapy data—to a Nepalese hospital, thereby demons...
Authors: Li Chen, Shouliang Ding, Xiaoyan Huang, Lecheng Jia, Hua Li, Hongdong Liu, Yanfei Liu, Zun Piao, Guangyu Wang
Affiliation: State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Shenzhen United Imaging Research Institute of Innovative Medical Equipment
Abstract Preview: Purpose: Optimal radiotherapy planning is challenging, influenced by anatomical factors such as surrounding organs and tumor characteristics, which complicate dose distribution and target coverage. Wh...
Authors: Robbie Beckert, Weiren Liu, Thomas R. Mazur, Allen Mo, Stephanie Perkins, Hailei Zhang, Tianyu Zhao
Affiliation: Washington University in St. Louis School of Medicine, University of South Florida, WashU Medicine
Abstract Preview: Purpose: Online adaptation may mitigate uncertainties in proton therapy arising from interfractional anatomical changes. While robust optimization accounts for setup and range uncertainties during pla...
Authors: Emily Hansen, Jay Mistry, Alois M. Ndlovu, Niara Rowe, Roland Teboh
Affiliation: Hackensack University Medical Center
Abstract Preview: Purpose: SCINTIX Biology-guided radiotherapy (BgRT) on the RefleXion X1 relies on a new planning system and advanced planning techniques. The first patient SCINTIX BgRT plans are compared to similar c...
Authors: Sunil Mani, Ilakiya Raghavendiran, Vasanthan Sakthivel, Skanda Kabilan Swamy
Affiliation: Edmond Santa Fe High School, Edmnd Deer Creek High, Cancer Specialists of North Florida, Advanced Medical Physics
Abstract Preview: Purpose: Purpose/Objective(s): To evaluate and validate the dose calculation and delivery accuracy for patients planned using diagnostic CT
Methods: A total of forty-two patients with palliative sp...
Authors: Pat Esposito, Ashley Klein, Carmine Verna, Ling Zhuang
Affiliation: Northwestern Medicine
Abstract Preview: Purpose: To evaluate dosimetric parameters and treatment delivery efficiency between volumetric modulated arc therapy (VMAT) and hybrid dynamic conformal arc (HDCA) on SRS and SBRT planning through st...
Authors: Chunhui Han, An Liu, Anthony Magliari, Lesley Rosa
Affiliation: Office of Medical Affairs, Varian, A Siemens Healthineers Company, Department of Radiation Oncology, City of Hope National Medical Center
Abstract Preview: Purpose: To evaluate the performance of a knowledge-based planning (KBP) optimization model for total marrow and lymphoid irradiation (TMLI) on a ring-gantry linac with a dual-layer MLC and to evaluat...
Authors: Thomas I. Banks, Bin Cai, Andrew R. Godley, Yang Kyun Park, Hao Peng, Rameshwar Prasad, Chenyang Shen, Shunyu Yan, Haozhao Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, University of Texas Southwestern Medical Center
Abstract Preview: Purpose:
The RefleXion® X1 (RefleXion Medical, Inc., Hayward, CA) uniquely integrates KVCT and PET as on-board image guidance for radiotherapy. It has been installed and commissioned for clinical u...
Authors: Miguel Albaladejo, Ana Corbalan, Aitor Ortega, Vicente Puchades, David Ramos, Alfredo Serna-Berna, Jonattan Suarez
Affiliation: Hospital General Universitario Santa Lucia
Abstract Preview: Purpose:
Prostate SBRT treatments are frequently delivered using standard VMAT IGRT technique. The aim of this study is to test the feasibility of Ethos Artificial Intelligence (AI) prostate SBRT b...
Authors: Christine V. Chung, Laurence Edward Court, Meena S. Khan, Ethan B. Ludmir, Rachael M. Martin Paulpeter, Saurabh Shashikumar Nair, Callistus M. Nguyen, Joshua S. Niedzielski, Luis Augusto Perles
Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Spatially Fractionated Radiation Therapy (SFRT) has re-emerged as an efficacious treatment approach for bulky solid tumors. RapidArc Dynamic (RAD) has unique beam delivery capabilities that m...
Authors: Girish Bal, Thomas I. Banks, Bin Cai, Neil Desai, Aurelie Garant, Orhan Oz, Elizeva Phillips, Rameshwar Prasad, Chenyang Shen, Robert Timmerman
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical
Abstract Preview: Purpose: This study reports findings from the first-in-human imaging-only trial evaluating the feasibility of using the novel PET tracer 68Ga-PSMA-11 (Illuccix) to guide external beam radiotherapy on ...
Authors: Md. Yousuf Ali, Parvin Akhter Banu, Ehteshamul Hoque, Qazi Mushtaq Hussain, Md Jobairul Islam, Md. Abdul Mannan, Sadia Afrin Sarah, Mostafa Aziz Sumon, Ahammad Al Mamun Sweet, AFM Kamal Uddin
Affiliation: Labaid Cancer Hospital & Superspeciality Centre
Abstract Preview: Purpose: Radiotherapy for left-sided breast cancer can induce cardiac injury. Deep Inspiration Breath Hold (DIBH) is a technique that minimizes cardiac exposure during treatment. This study compares d...
Authors: Kenneth L. Homann, Natalie A Lockney, Hong Zhang
Affiliation: Department of Radiation Oncology, Vanderbilt University Medical Center, Vanderbilt University Medical Center
Abstract Preview: Purpose: The aim of this study is to develop a treatment planning methodology utilizing liver functional imaging via contrast-enhanced Magnetic Resonance Imaging (MRI) in patients undergoing stereotac...
Authors: Cheryl Anderson, Lara Best, Amanda Cherpak, Jennifer DeGiobbi, Marc C. LeBlanc, R. Lee MacDonald, Peter R. Martin, Natasha McMaster, Murali Rajaraman, James L. Robar, Lucy Ward, Derek Wilke, Kenny Zhan
Affiliation: Department of Radiation Oncology, QE2 Cancer Centre, Nova Scotia Health
Abstract Preview: Purpose: This work investigates the potential benefit of adaptive planning using the Ethos radiotherapy system (Varian Medical Systems) with direct-dose calculation on HyperSight cone beam CT (CBCT) f...
Authors: Xiangli Cui, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences
Abstract Preview: Purpose:
Respiratory motion introduces substantial dose uncertainties in lung cancer radiotherapy, particularly affecting dose distribution in Simultaneous Integrated Boost-Stereotactic Body Radiot...
Authors: Minbin Chen, Gang Liu, Manju Liu, Weiwei Sang, Pulin Sun, Mingyuan Ye, Fang-Fang Yin, Lihua Zhang, Haiming Zhu
Affiliation: Jiahui International Hospital, Radiation Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, The First People's Hospital of Kunshan
Abstract Preview: Purpose: This study aims to evaluate the effects of varying the number of arcs on treatment plans created using Volumetric Modulated Arc Therapy (VMAT) for Lattice radiotherapy (LRT).
Methods: Thre...
Authors: Anupama Chundury, Hyejoo Kang, John C. Roeske, Iris A. Rusu
Affiliation: Loyola University Medical Center, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago
Abstract Preview: Purpose: To quantify the dosimetric impact of six degrees of freedom (6DoF) intrafractional errors on gross tumor volume (GTV) and planning target volumes (PTV) for single-isocenter multi-target stere...
Authors: Andreea Dimofte, Maksym Sharma, Weibing Yang, Timothy C. Zhu
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose:
To assess the effectiveness and dosimetric impact of utilizing a knowledge-based planning model for GI site-specific plans.
Methods:
Six knowledge-based planning models were develope...
Authors: Nobuki Imano, Daisuke Kawahara, Akito S Koganezawa, Yuji Murakami, Ikuno Nishibuchi, Takuya Wada
Affiliation: Department of Information and Electronic Engineering, Faculty of Science and Engineering, Teikyo University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University
Abstract Preview: Purpose: Adaptive radiotherapy (ART) compensates for treatment plans based on anatomical changes while not considering biological effects such as interruptions during treatment. This study aims to dev...
Authors: Shahed Badiyan, Chien-Yi Liao, Mu-Han Lin, Dan Nguyen, Justin D. Visak, Hui Ju Wang, Brien Timothy Washington, Kenneth Westover, Yuanyuan Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Knowledge-based planning (KBP) plays a crucial role in improving treatment plans by leveraging previous clinical data to guide new cases. KBP is applied to the Ethos 2.0 Intelligent Optimizat...
Authors: Eyub Y. Akdemir, Gregory A Azzam, Rupesh Kotecha, Gregory J. Kubicek, Natalia Lutsik, Eric Mellon, Siamak P. Nejad-Davarani, Parag Parikh, Karen C. Snyder
Affiliation: Miami Cancer Institute, Baptist Health South Florida, Department of Radiation Oncology, University of Miami, Henry Ford Health
Abstract Preview: Purpose: Resection cavity volumes shrink gradually over time after surgical resection of brain metastases. Fractionated stereotactic radiosurgery (fSRS) is often delivered to the cavity to prevent rec...
Authors: Bin Cai, Andrew R. Godley, Brian A. Hrycushko, Heejung Kim, Mu-han Lin, David D.M. Parsons, Justin D. Visak, Da Wang, Tingliang Zhuang
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: The standard radiation therapy workflow requires CT-simulation and planning, whether for initial treatments or re-planning due to significant anatomical changes. IPART instead uses one patien...
Authors: Xiaoda Cong, Xuanfeng Ding, Gang Liu, Peilin Liu, Jiajian Shen
Affiliation: Department of Radiation Oncology, Mayo Clinic, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Corewellhealth William Beaumont University Hospital
Abstract Preview: Purpose: This study aims to develop the first SPArc optimization algorithm based on the Dynamic Programming (SPArc-DP), to improve the treatment delivery efficiency for synchrotron-accelerator-based P...
Authors: Awens Alphonse, Nebi Demez, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Gagandeep Saini, Nishan Shrestha, Somol Sunny
Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida
Abstract Preview: Purpose: This study examined the impact of varying the pitch factor in hippocampal-avoidance whole-brain (HP-WB) radiotherapy treatments, utilizing the newly introduced VOLO Ultra optimization for Hel...
Authors: Jimmy Caudell, Eduardo G. Moros, Nour Nasser, Gage H. Redler, George Yang
Affiliation: Moffitt Cancer Center
Abstract Preview: Purpose: Dosimetric evaluation of PTV margin reduction for Head and Neck(H&N) sequential boost plans using the Ethos online adaptive radiotherapy(oART) system to investigate the tradeoff in decreased ...
Authors: Andres Portocarrero Bonifaz, Ian Schreiber
Affiliation: CARTI Cancer Center
Abstract Preview: Purpose: To explore how calculation grid resolution, along with other planning factors, affects head and neck dose calculation accuracy and contributes to potential discrepancies in the Eclipse Treatm...
Authors: Shen Fu, Zhangmin LI, Zuofeng LI, Yuanshui Zheng
Affiliation: GuangZhou Concord Cancer Center, Guangzhou Concord Cancer Center
Abstract Preview: Purpose: To investigate the influence of different robustness optimization strategies and parameters in proton therapy plans for head and neck tumors on target coverage and OAR (organ at risk) sparing...
Authors: Hassan Bagher-Ebadian, Anthony J. Doemer, Ryan Hall, Joshua P. Kim, Bing Luo, Benjamin Movsas, Humza Nusrat, Kundan S Thind
Affiliation: Department of Physics, Toronto Metropolitan University, Henry Ford Health
Abstract Preview: Purpose: This study investigates the development and feasibility of local LLM-based agents to automate radiotherapy treatment planning, aiming to improve planning efficiency and consistency, while pre...
Authors: Yang Sheng, Qingrong Jackie Wu, Qiuwen Wu, Xin Wu, Dongrong Yang
Affiliation: Duke University Medical Center
Abstract Preview: Purpose:
This study aims to leverage large language model (LLMs) to develop a human-in-the-loop agentic framework, enhancing the efficiency of treatment planning in radiotherapy.
Methods:
A L...
Authors: Xianjin Dai, PhD, Wu Liu, Eric Nguyen, Lei Xing, Lewei Zhao
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, Department of Radiation Oncology, Stanford University
Abstract Preview: Purpose: Recent developments in hybrid quantum solvers, which combine quantum and classical processing, enable greater flexibility to tackle problems outside the limited scope of pure quantum computin...
Authors: Nina Burbure, Tawfik G. Giaddui, Shidong Li, Curtis Miyamoto, Jeremy Price, Bin Wang
Affiliation: FCCC at Temple University Hospital
Abstract Preview: Purpose: To evaluate the performance of KBP models for hypo-fractionated prostate and pelvic lymph nodes (LN) VMAT plans.
Methods: A KBP model (TUH KBP) was developed in Eclipse treatment planning ...
Authors: Peng Dong, Lei Xing
Affiliation: Department of Radiation Oncology, Stanford University, Stanford University
Abstract Preview: Purpose: Volumetric Modulated Arc Therapy (VMAT) optimization is a complex, non-convex problem with numerous variables and intricate constraints. Traditional optimization methods often lack efficiency...
Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang
Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center
Abstract Preview: Purpose: Using mixed fractionation schemes is a common technique in treating CNS lesions. This article describes an innovative plan-and-split approach for more efficient planning on the ZAP-X and thus...
Authors: Shahed Badiyan, Girish Bal, Thomas I. Banks, Bin Cai, Tu Dan, Aurelie Garant, Andrew R. Godley, Steve Jiang, Orhan Oz, Arnold Pompos, Rameshwar Prasad, Chenyang Shen, David Sher, Robert Timmerman, Kenneth Westover
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical
Abstract Preview: Purpose: Biology-guided radiotherapy (BgRT) is a novel FDA-cleared technology for treating lung and bone tumors based on 18F-FDG PET uptake. This study summarizes the first-year experience treating 29...
Authors: Kin Yin Cheung, Chen-Yu Huang, Chi Wah Kong, Ka Ki Lau, Pei-Xiong Li, Darren M. C. Poon, Bin Yang, Siu Ki Yu, Jing Yuan, Chi To Yung, Shang Peng Felix Yung
Affiliation: Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Medical Physics Department, Hong Kong Sanatorium and Hospital, Research Department, Hong Kong Sanatorium and Hospital
Abstract Preview: Purpose: This study investigates optimal treatment strategies utilizing MR-linac for extremity lesions, with a specific focus on a 0.6 cm deep lesion in the right palm. The magnetic field-induced dose...
Authors: William N. Duggar, John C. White
Affiliation: UMMC, University of Mississippi Medical Center
Abstract Preview: Purpose:
To evaluate the impact of patient motion on PTV coverage for 95% and 90% target volumes in VMAT breast treatment plans and to determine the appropriate flash margins required to maintain r...
Authors: Wouter Crijns, Frederik Maes, Loes Vandenbroucke, Liesbeth Vandewinckele
Affiliation: Department of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven; Department of Radiation Oncology, UZ Leuven, Department ESAT/PSI, KU Leuven; Medical Imaging Research Center, UZ Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven
Abstract Preview: Purpose: To explore intentional deep overfit learning (IDOL) to exploit the initial treatment plan to predict an adaptive radiotherapy plan.
Methods: A conditional generative adversarial network is...
Authors: Jian Chen, Qiufen Guo, Aihua Li, Jing Liu, Junjie MA, Qian WU, Haonan Xiao, Peng Xie, Xiaohui Yan, Yong Yin, Zhe Zhang
Affiliation: Department of Radiation Oncology, Peking University Shenzhen Hospital, Department of Radiation Oncology and Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Department of Obstetrics and Gynaecology, Liao Cheng People’s Hospital
Abstract Preview: Purpose: Online Adaptive radiation therapy (ART) has been an effective technique to manage patient’s inter-fractional anatomical changes and therefore reduces planning target volume (PTV). However, on...
Authors: Michael Bowers, Patrik Brodin, Madhur Garg, Rafi Kabarriti, William P. Martin, Todd R. McNutt, Julie Shade, Wolfgang A. Tomé, Christian Velten
Affiliation: Johns Hopkins University, Oncospace, Inc., Montefiore Medical Center
Abstract Preview: Purpose: Development of an automated planning tool utilizing AI generated patient-specific dose-volume histogram predictions for rapid H&N plan generation.
Methods: Planning best-practices were dev...
Authors: Mireille Conrad, Cédric De Marco, Marie Fargier-Voiron, Maud Jaccard, Oscar Matzinger, Nicolas Joel Lionel Perichon
Affiliation: Clinique De Genolier
Abstract Preview: Purpose: The Accuray Synchrony real-time motion fiducial tracking solution allows for prostate stereotactic treatment on both Cyberknife and Radixact machines. In our radiotherapy department, two solu...
Authors: Ahmad K. Al-Basheer, Andrew Clarke Grice, Kelly E. Hosier, Mark Logsdon, Evan A. Silverstein, Chris Tunnicliff, Chuan Wu
Affiliation: Sutter Medical Foundation, Sutter Health
Abstract Preview: Purpose: For Prostate SBRT Boost treatments, determine whether a uniform 2mm CTV to PTV margin is sufficient to give 95% dose coverage to the CTV in 90% of patients via a modified Van Herk Margin Form...
Authors: Jiahao Chen, Yunwen Huang, Yidong Yang, Shanshan Zhang, Ning Zhao, Cheng Zheng
Affiliation: Department of Life Sciences and Medicine, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China, University of Science and Technology of China
Abstract Preview: Purpose: To develop a molecular image-guided radiotherapy technique for accurate and effective radiation treatment using quantitative fluorescence molecular tomography (FMT).
Methods: X-ray cone be...
Authors: Dante PI Capaldi, Lu Jiang, Qihui Lyu, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Preclinical small animal studies help understand radiation-induced biological responses, toxicities, and mechanisms, facilitating the translation of new therapies to patient treatment. Int...
Authors: William T. Hrinivich, Junghoon Lee, Lina Mekki
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Biomedical Engineering, Johns Hopkins University, Johns Hopkins University
Abstract Preview: Purpose: Volumetric modulated arc therapy (VMAT) planning is a computationally expensive process. In this work, we propose a reinforcement learning (RL) framework to automatically optimize dose rate a...
Authors: Carl D. Elliston, Lawrence Koutcher, Michael J. Price, Adam C. Riegel, Michael B Sisti, Tony J.C. Wang, Andy (Yuanguang) Xu
Affiliation: Columbia University Irving Medical Center
Abstract Preview: Purpose: An inverse treatment planning software was recently introduced to Gamma Knife radiosurgery. The purpose of this study is to compare the plan quality of the Gamma Knife ”Lightning” with that o...
Authors: Karam Ayoub, Aaron B Hesselson, Ronald C McGarry, Joshua Misa, Damodar Pokhrel
Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Department of Cardiology
Abstract Preview: Purpose: Noninvasive stereotactic body radiosurgery (SBRS) is emerging treatment option for advanced heart failure patients with refractory-ventricular tachycardia (rVT) who experienced recurrent impl...
Authors: Eric C. Ford, Yulun He, Minsun Kim, Dustin Melancon, Juergen Meyer, Dong Joo Rhee, Yinghua Tao
Affiliation: Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, MD Anderson Cancer Center, University of Washington
Abstract Preview: Purpose: To develop and evaluate an automated-planning technique capable of generating high-quality treatment plans for hippocampal-sparing-whole-brain radiation therapy.
Methods: An auto-planning ...
Authors: Avery Antes, Bulent Aydogan, Rama Chicfeh, Erik Pearson, Neslihan Sarigul
Affiliation: The University Of Chicago, The University of Chicago
Abstract Preview: Purpose: This study evaluates the performance of the Ethos Treatment Planning System (TPS) in managing oligometastatic cancer patients previously treated using multiple isocenter plans.
Methods: Th...
Authors: David L. Barbee, Jose R. Teruel Antolin, Jinyu Xue
Affiliation: NYU Langone Health
Abstract Preview: Purpose: This work introduces a method of regional dose evaluation of normal brain tissue using local target-specific evaluation and compares to global dose evaluation for linac-based single-isocenter...
Authors: Alyssa Gadsby, William J. Godwin, Daniel G. McDonald, Jean L. Peng, Alek K. Rapchak, Sean A Roles, Austin M. Skinner, Stephanie Tan
Affiliation: Medical University of South Carolina
Abstract Preview: Purpose: To utilize multi-criteria optimization (MCO) in a targeted fashion to quickly and easily improve dose to the rectum when treating the prostate with stereotactic body radiation therapy (SBRT)....
Authors: Lei Fu, Eric Gressen, Yingcui Jia, Shari Rudoler, Yevgeniy Vinogradskiy, Qianyi Xu
Affiliation: Thomas Jefferson University
Abstract Preview: Purpose: InTempo imaging in the Accuray CyberKnife System improves the ability to track/correct target motion during treatment. However, no studies have provided information on the impact of InTempo I...
Authors: Yunfeng Cui, Joseph P. Kowalski, Qiuwen Wu, Yibo Xie
Affiliation: Duke University, Duke University Medical Center
Abstract Preview: Purpose: A Varian Ethos/Halcyon linac was recently commissioned in our clinic and was used to treat head and neck cancer patients. The purpose of this study is to compare treatment plan quality and de...
Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang
Affiliation: University of Kentucky, Department of Radiation Medicine
Abstract Preview: Purpose: Demonstrating the feasibility of dose escalation for stereotactic recurrent head and neck (RHN) cancers through the deployment of a Hyper-Arc Based RapidPlan (HARP) model through an Eclipse S...
Authors: Jameson T. Baker, Sean T Grace, Cindy Pham, Michael A. Trager
Affiliation: Northwell
Abstract Preview: Purpose:
In VMAT planning, increasing complexity in MLC motion and modulation may improve dose distributions and OAR sparing while maintaining PTV coverage. However, increasing complexity can creat...
Authors: Avinash Mudireddy, Nathan Shaffer, Joel J. St-Aubin
Affiliation: University of Iowa
Abstract Preview: Purpose: This work demonstrates preliminary results in training a reinforcement learning (RL) network to perform VMAT machine parameter optimization.
Methods: We implemented a policy gradient RL al...