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Results for "ranged head": 106 found

4π Non-Coplanar Stereotactic Body Radiation Therapy: Dosimetric Evaluation of VMAT Configurations in for Recurrent Head and Neck Tumors

Authors: Sixue Dong, Weigang Hu, Jiazhou Wang, Zhen Zhang

Affiliation: Fudan University Shanghai Cancer Center

Abstract Preview: Purpose: This study aimed to evaluate the dosimetric benefits and treatment efficiency of different beam configurations in 4π non-coplanar VMAT for SBRT in recurrent head and neck tumors

Method...

A Comparative Analysis of Hand Calculations and Macro Monte Carlo Simulations for Electron Beam Dosimetry

Authors: Mohamed Eldib, Adam Mahl, Moyed Miften, Rachel Petragallo, Kelly L. Stuhr

Affiliation: University of Colorado - Anschutz Medical Campus, University of Colorado School of Medicine, University of Colorado Denver, Department of Radiation Oncology, University of Colorado

Abstract Preview: Purpose: To compare electron beam dose calculations performed manually with those computed using the Macro Monte Carlo simulation for standard fields on both phantom and patient setups, with the aim o...

A Fast Low-Dose Method for Beam Blocker-Based CBCT Scatter Correction

Authors: Yidong Yang, Haolin Zhan

Affiliation: Department of Engineering and Applied Physics, University of Science and Technology of China, University of Science and Technology of China

Abstract Preview: Purpose: To develop a fast low-dose method for beam blocker-based CBCT scatter correction and evaluate image quality in phantom study.
Methods: The full number of scatter projections were collected...

A Motion Analysis of Cardiac Substructures for Guiding Stereotactic Arrhythmia Radiotherapy Motion Management

Authors: Hongyu An, Phillip Cuculich, H Michael Gach, Yao Hao, Trevor McKeown, Clifford Robinson, Yuhao Wang, Deshan Yang

Affiliation: Washington University School of Medicine in St. Louis, Washington University School of Medicine, Duke University, Department of Radiation Oncology, Duke University, Washington University in St. Louis, Department of Radiation Oncology, Washington University School of Medicine in St. Louis

Abstract Preview: Purpose: This study investigated cardiac motion characteristics of ventricular tachycardia patients to support patient-specific motion management for stereotactic arrhythmia radiotherapy (STAR) treatm...

A New Way to Assess Dynamic Response of Centrally Located Lung Cancer (CLLC) to SBRT and Conventional Radiation Therapy (CRT)

Authors: Nina Burbure, Tawfik Giaddui, Shidong Li, Curtis Miyamoto, Jeremy Price, Bin Wang

Affiliation: FCCC at Temple University Hospital, Dept. of Radiation Oncology, Fox Chase Cancer Center at Temple University Hospital

Abstract Preview: Purpose: Higher rates of local failures and toxicities challenged radiation therapy of centrally located lung cancer (CLLC). We assessed the treatment response by measuring the early changes of PET+ n...

A Novel Linac Onboard Dual-Layer Kv Imager Provides Increased Clinical CBCT Contrast and Metal Artifact Reduction Using Virtual Monoenergetic Images

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Dual-energy imaging offers benefits, including metal artifact reductions (MAR) and improved contrast, that enhance visualization. Currently, dual-energy imaging is largely limited to CT scann...

A Novel Setup for Flash Radiotherapy Beam Delivery at Isocenter Using Downstream Electron Scattering

Authors: Dale W. Litzenberg, Ikechi S Ozoemelam, Rowan Paplanus, Michael Pillainayagam, Donald A. Roberts

Affiliation: University of Michigan, Oregon Health & Science University

Abstract Preview: Purpose: Clinical linear accelerators use dual foil scattering systems designed to achieve large uniform fields (up to 25×25cmÂČ), which can reduce beam fluence by up to 93% compared to the unmodified ...

Adapting Newer Treatment Planning Strategy for Uveal Melanoma Cases Using Gamma Knife Radiosurgery

Authors: Deepak Agrawal, Subhash Gupta, Shashanksharad Kale, Gopishankar Natanasabapathi, Manoj Phalak, Dhanabalan Rajasekaran, Surendra Kumar Saini, Subramani Vellaiyan

Affiliation: All India Institute of Medical Sciences (AIIMS), All India Institute of Medical Sciences

Abstract Preview: Purpose:
To evaluate planning strategy for uveal melanoma tumor (UM) in gamma knife stereotactic radiosurgery (GKSRS) using Lightning inverse planning software for treatment planning.
Methods:

Advancements and Cost-Effectiveness of Proton Therapy in the Global Oncology Landscape

Authors: Aman Anand, Jonathan B. Ashman, Martin Bues, Brady S. Laughlin, Lisa McGee, Justin Pettit, Fan Yang, Libing Zhu

Affiliation: Department of Radiation Oncology Mayo Clinic, Mayo Clinic Arizona, Mayo Clinic

Abstract Preview: Purpose: Proton therapy (PT) offers significant clinical and economic benefits across various cancers, whereas it also has faced skepticism due to its historically high costs and perceived overuse in ...

An Automated Approach to Monitoring Clinical Protocols Against a Master Protocol

Authors: Jeremy Christophel, Zhihua Qi

Affiliation: Henry Ford Health

Abstract Preview: Purpose: To demonstrate a method to compare DICOM metadata from clinical scanners with institutional protocols as validation that clinical use matches the master protocol.
Methods: DICOM metadata i...

Analysis of Noise Power Spectra in MR Parallel Imaging

Authors: Sulaiman D. Aldoohan, Gerardo Garcia

Affiliation: University of Toledo Medical Center

Abstract Preview: Purpose: To evaluate the noise power spectra (NPS) of images acquired using parallel imaging with varying acceleration factors in 1-D and 3-D spaces and to compare the level of the power of the noise ...

Analysis of Structure Errors in Region of Interest Contouring for Radiotherapy Planning: A Study Using the RT-Contour QA Platform

Authors: Sijuan Huang, Zi LIU, Jing MA, Xin Yang

Affiliation: Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, 510060, China

Abstract Preview: Purpose: To reduce the pressure of manual review of abnormal situations in manually/automatically delineated regions of interest (ROI), improve its accuracy and basis.
Methods: 220 radiotherapy pat...

Assessing the Feasibility of LD-V1 Film for Annual Kilovoltage Imaging Dose Measurements

Authors: Maria F. Chan, Seng Boh Gary Lim, Shih-Chi Lin, Dustin W. Lynch, Usman Mahmood, Jeonghoon Park

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To explore the feasibility of using GafChromic LD-V1 film for annual imaging dose assessment across kV radiography, fluoroscopy, and cone beam computed tomography (CBCT) imaging protocols, as...

Automated Determination of Deteriorations in Proton Therapy Plan Quality Using Daily Cone Beam CT As a Predictor of Need for Adaptive Replans for Head and Neck Cases

Authors: Matthew J Ferris, Jason K Molitoris

Affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, University of Maryland

Abstract Preview: Purpose: Anatomy changes often happen in head-and-neck (HN) patients treated with proton radiation therapy. These changes can result in deteriorations of target dose coverage and increased dose to org...

Automating Protocol-Specific Chart Checking in Radiotherapy

Authors: Jiajin Fan, Ulrich Langner, Qiongge Li, Jian Liu, Wei Nie, Edwin Quashie

Affiliation: Brown University Health, Hofstra University Medical Physics Program, Inova Hospital, Inova Schar Cancer Institute, Indiana University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose:
Chart checking in radiotherapy ensures treatment plans meet clinical and safety standards. For patients in clinical trials, protocol-specific requirements add complexity, making manual rev...

BEST IN PHYSICS MULTI-DISCIPLINARY: Evaluation of Spot-Level N-12 PET Imaging for Online Range Verification in Multi-Field Intensity Modulated Proton Therapy

Authors: Zahra Ahmadi Ganjeh, Stefan Both, Peter Dendooven, Jeffrey Free, Brian Zapien Campos

Affiliation: Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Particle Therapy Research Center (PARTREC), Department of Radiation Oncology, University Medical Center Groningen, University of Groningen

Abstract Preview: Purpose: Positron emission tomography (PET) has been investigated for range monitoring in intensity-modulated proton therapy (IMPT), but real-time feedback been limited due to the focus on long-lived ...

BEST IN PHYSICS RADIOPHARMACEUTICALS, THERANOSTICS AND NUCLEAR MEDICINE: Characterization and Dose Rate Calibration of a Semiconductor-Based Radiation Imaging Survey Meter

Authors: Steven Brown, Mike Hopkins, Jerimy C. Polf, Scott Sawyer, Benjamin L. Viglianti

Affiliation: H3D, inc, University of Michigan, M3D, Inc, M3D Imaging

Abstract Preview: Purpose: We characterized the sensitivity, energy dependence, and calibrated dose rate for a radiation imaging survey meter (RAVIN Cam; M3d inc., Ann Arbor MI) based on cadmium zinc telluride (CZT) cr...

Beam Characteristics of a Proposed Dielectric Wall Proton Accelerator Design

Authors: Julien Bancheri, Chau Giang Bui, Christopher M Lund, Morgan J Maher, Jamiel Nasser, Amy Parent, Monica Serban, Jan P. Seuntjens, Jason Z Yuan

Affiliation: University of Toronto, Medical Physics Unit, McGill University, Princess Margaret Cancer Centre, Princess Margaret Cancer Centre & University of Toronto

Abstract Preview: Purpose: Proton therapy (PT) has demonstrated greater precision and superior healthy tissue sparing compared to photon radiotherapy for various sites; however, PT systems are expensive, which limits g...

Best- and Worst-Case Scenario: Uncertainty Bounds Informed By Daily Scanning in Weekly CBCT-Based Accumulated Dose for Head and Neck Cancer

Authors: Peter Balter, Kristy K. Brock, Clifton David Fuller, Tze Yee Lim, James Long, Brigid A. McDonald, Androniki Mitrou, Andrew J. Schaefer, Stina Svensson

Affiliation: The University of Texas MD Anderson Cancer Center, RaySearch Laboratories, Rice University, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences

Abstract Preview: Purpose: CBCT-based accumulated dose can provide up-to-date dose information on responding anatomy. To optimize resources, it is necessary to determine how many scans provide adequate information for ...

Characterization of Novel Shielded and Unshielded Silicon Diode Detectors for Photon and Electron Dosimetry in Radiation Therapy

Authors: Mohamad Ahmad Alissa, Carson Brame, Damian Czarnecki, Olivier Evrard, Charbel A. Habib, Jeff Hildreth, Andy Murray, Andreas Schönfeld, Ann-Britt Schönfeld, David Towle, Gerd Wessing

Affiliation: CDT-West - Centrum fĂŒr Diagnostik und Therapie, Radiologie Vechta, Technische Hochschule Mittelhessen, MyMichigan Health, Sun Nuclear Corp., Mirion Technologies

Abstract Preview: Purpose: To characterize the performance of novel shielded and unshielded silicon diode detectors in relative photon and electron beam dosimetry.

Methods: The novel shielded and unshielded sili...

Characterizing an Osld Dosimetry System for Use in a Multi-Clinic Environment

Authors: Amar K. Basavatia, Lee C. Goddard, Rachel Grimm, Wolfgang A. Tomé

Affiliation: Montefiore Medical Center

Abstract Preview: Purpose: To characterize the “MyOSL Chip” OSLD system for clinical use and compare the response of multiple readers to allow for utilization in a multi-clinic environment.
Methods: Dose calibration...

Comparison of CBCT Dose Calculation Accuracy between Truebeam Hypersight Image Reconstruction Algorithms

Authors: Sarah Aubert, Harald Keller, Jeff D. Winter

Affiliation: Princess Margaret Cancer Centre

Abstract Preview: Purpose: Support for treatment planning directly on CBCT imaging on C-arm linacs will enable adaptive radiation therapy (ART) capacity with increased treatment technique flexibility. The HyperSight im...

Computed Tomography Organ Dose Library Derived from Newly Developed Newborn-Infant-Toddler Computational Phantoms

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Adam Leon Kesner, Cameron B. Kofler, Juan Camilo Ocampo Ramos, Yitian Wang, Stefan Wehmeier

Affiliation: University of Chicago, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: To develop a slice-specific computed tomography (CT) organ dose library using Monte Carlo radiation transport simulations on a newly created set of newborn, infant, and toddler computational ...

Correlation of Dose Volume Metrics with Skin Systemic Sclerosis 12 Months Post Radiotherapy for Head & Neck Cancer

Authors: Gregory A Azzam, Danielle Cerbon, Laura Huang, Panayiotis Mavroidis, Diana Molinares, Stuart E Samuels, Sotirios Stathakis

Affiliation: Mary Bird Perkins Cancer Center, University of Miami Sylvester Comprehensive Cancer Center, Mount Vernan Rehabilitation Medicine Associates, Department of Radiation Oncology, University of Miami, University of North Carolina

Abstract Preview: Purpose: This study examines the correlation of different dose volume metrics of the skin, sternocleidomastoid (SCM) muscle and subcutaneous tissue (subcut) structures with the skin systemic sclerosis...

Deep Dive of Clinical 5DCT Patient Results

Authors: Ryan Andosca, Peter Boyle, Minji Victoria Kim, Michael Vincent Lauria, Daniel A. Low, Claudia R. Miller, Drew Moghanaki, Louise Naumann, Dylan P. O'Connell, Ricky R Savjani

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, UCLA, University of California, Los Angeles, UCLA Radiation Oncology

Abstract Preview: Purpose: To demonstrate the performance of the model-based CT scanning protocol, 5DCT, as an alternative to 4DCT.
Methods: 5DCT imaging results for 242 patients were analyzed. Implementation of the...

Deep Learning-Based Auto Segmentation of Oars in Head and Neck Radiation Therapy

Authors: Laila A Gharzai, Bharat B Mittal, Poonam Yadav

Affiliation: Northwestern Feinberg School of Medicine, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine

Abstract Preview: Purpose: Multiple studies have shown the increasing role of deep learning in segmenting regions of interest. This work presents the feasibility of auto-segmenting the critical structures for head and ...

Demographic Attributes of the Train-Test Sets and Their Impact on AI Performance: Medical Imaging Applications

Authors: Maryellen L. Giger, Fahd Hatoum, Robert Tomek, Heather M. Whitney

Affiliation: The University of Chicago

Abstract Preview: Purpose: To assess the importance of applying stratified sampling across demographic attributes (including age, sex, race, and ethnicity) when constructing training and testing datasets for ML-based d...

Deployable Twin-Calorimeter System for Absolute Dose Measurements By Clinical Physicists

Authors: Jean Dessureault, Malcolm R. McEwen, Bryan R. Muir, James Renaud

Affiliation: National Research Council

Abstract Preview: Purpose: To develop and commission a mailable calorimeter that enables clinical medical physicists to quickly and efficiently address innovative dosimetry challenges directly at the point of use.
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Design and Testing of an External Control System for Beam Control and Pre-Delivery Optimization for Conventional- and Ultra-High-Dose-per-Pulse Flash Irradiations

Authors: Alexander Baikalov, Luke Connell, Nicholas Coupey, Nolan M. Esplen, Rebecca Lim, Chinh Nguyen, Emil Schueler

Affiliation: Northwell, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: FLASH radiotherapy delivered using electron linear accelerators (LINAC) requires precise control and minimal variation of dose rate and We developed a robust external beam control system (EBC...

Development of Patient-Specific Lead Ball Compensator for Total Body Irradiation

Authors: Chang Heon Choi, Minjae Choi, Yoonsuk Huh, Jin Jegal, Jung-in Kim, So-Yeon Park

Affiliation: Department of Radiation Oncology, Veterans Health Service Medical Center, Department of Radiation Oncology, Seoul National University Hospital

Abstract Preview: Purpose: Total Body Irradiation (TBI) aims to achieve a uniform dose distribution across the entire body. However, in conventional TBI setups that use extended source-to-surface distance (SSD) and lea...

Diffusion Model-Based Motion Correction in Portable Computed Tomography for Brain: Human Observer Study

Authors: Rajiv Gupta, Rehab Naeem Khalid, Min Lang, Michael H Lev, Quirin Strotzer, Matthew Tivnan, Maryam Vejdani-Jahromi, Dufan Wu, Siyeop Yoon, Chen Zhennong

Affiliation: Massachusetts General Hospital

Abstract Preview: Purpose: Patient motion is a major source of artifacts in portable brain CT due to the slow scanning speed. A diffusion model was developed to reduce these motion artifacts. This work aims to assess t...

Dose Reconstruction from Prompt-Gamma Imaging Towards Real-Time Adaptive Proton Therapy

Authors: Thomas R. Bortfeld, Prof. Elisabetta De Bernardi, Tianxue Du, Beatrice Foglia, Chiara Gianoli, Takamitsu Masuda, Katia Parodi, Marco Pinto, Boon-Keng Kevin Teo, Yunhe Xie

Affiliation: Department Of Radiation Oncology, Massachusetts General Hospital (MGH), School of Medicine and Surgery, University of Milano-Bicocca, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t MĂŒnchen (LMU Munich), Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen, National Institutes for Quantum Science and Technology (QST), University of Pennsylvania, Department of Experimental Physics - Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen

Abstract Preview: Purpose: The full potential offered by protons in clinical practice is limited by range uncertainties. One possibility for monitoring is through secondary prompt gammas (PG). PG emission along the pen...

Dosimetric Analysis of Lymphopenia after Lung Irradiation and Modeling the Probability of Normal Tissue Complications

Authors: Tianyuan Dai, Xiaoying Fan, Shuting Wang, Yong Yin

Affiliation: Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: Decreased lymphocytes increase the risk of infections and other problems. Radiation exposure can cause the development of severe lymphopenia. In this study, we used a dynamic blood flow model...

Dosimetric Evaluation of a Helical Tomotherapy to L-Shaped Linac Plan Conversion Workflow

Authors: Megan E. Daly, Ryan D. Hernandez, Abriel J. Horak, Soo Kyoung Kim, Peter C. Park, Dwaine O. Spence, Payton H. Stone, Cari L. Wright

Affiliation: UC Davis Cancer Center

Abstract Preview: Purpose: To evaluate a fallback planning workflow used for cross-modality treatment planning and delivery between helical Tomotherapy and volumetric modulated arc therapy (VMAT) using conventional L-s...

Early Imaging Identification of Osteoradionecrosis and Classification Using the Novel Clinrad System

Authors: Serageldin Attia, Zayne Belal, Cem Dede, Clifton David Fuller, Andrew Hope, Laia Humbert Vidan, Kate Hutcheson, Zaphanlene Kaffey, Stephen Y. Lai, Abdallah Mohamed, Amy Moreno, Jillian Rigert, Erin Watson

Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Princess Margaret Cancer Centre, University Health Network, 610 University Ave., The University of Texas MD Anderson Cancer Center, UT MD Anderson, Princess Margaret Cancer Centre, UT MD Anderson Cancer Center, Hospital of the University of Pennsylvania, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Head and Neck Surgery, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology

Abstract Preview: Purpose: Osteoradionecrosis (ORN) of the jaw is a debilitating radiation-induced toxicity lacking standardized classification criteria or treatment guidelines. Early identification of tissue injury co...

Efficient Robustness Optimization in Intensity Modulated Proton Therapy for Head and Neck Cancer Via Visual State Space Attention Generative Adversarial Networks (VSSA-GAN)

Authors: Nan Li, Yaoying Liu, Shouping Xu, Gaolong Zhang

Affiliation: Department of Radiation Oncology, School of Physics, Beihang University, School of physics, Beihang University, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Abstract Preview: Purpose: In intensity-modulated proton therapy (IMPT) for head and neck cancer, CBCT registration ensures accurate setup, minimizing dose errors. Unlike IMRT, IMPT plans directly define tumor volumes ...

Enhanced Surface Dose Accuracy in Proton Treatment Planning: Optimizing External Volume HU Thresholding.

Authors: Michael Butkus, Camilo M. Correa Alfonso, Olga M. Dona Lemus, James Arthur Perez-Sanchez

Affiliation: University of Miami

Abstract Preview: Purpose: Accurate skin dose calculation is essential for treating superficial lesions such as those of the breast, chest wall, and scalp. Clinical treatment planning systems often rely on approximatio...

Enhancing Dose Conformity in Halcyon SRS Plans: A Novel Approach Using Optimized Collimator Angles and Sub-Arcs.

Authors: David Chighvinadze, Chieh-Wen Liu, Sugandima Weragoda, Ping Xia

Affiliation: Cleveland Clinic Sandusky, Cleveland Clinic

Abstract Preview: Purpose: To explore the feasibility of using coplanar beams with collimator angle optimization for brain SRS plans with Halcyon system.
Methods: This study used a dataset of 26 patients with 2-3 br...

Evaluating Commercial Auto-Segmentation Software: Is Performance on Pediatric Organs-at-Risk Accurate?

Authors: Gregory T. Armstrong, James E. Bates, Lei Dong, Ralph Ermoian, Jie Fu, Christine Hill-Kayser, Rebecca M. Howell, Sharareh Koufigar, John T. Lucas, Thomas E. Merchant, Tucker J. Netherton, Sogand Sadeghi

Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, St. Jude Children's Research Hospital, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Department of Radiation Oncology, St. Jude Children’s Research Hospital, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, University of Washington/ Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: This study evaluates the adaptability and limitations of commercially available (MIM, RayStation) tools trained on predominately adult datasets (ages 20–60+ years) for delineating organs at r...

Evaluating LiF:Mg,Ti TLD Reliability at Body Temperature for Long-Term Dose Monitoring

Authors: Larry A. DeWerd, Keith A. Kunugi, Autumn Rasmussen

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison

Abstract Preview: Purpose: Ensuring the validity of the thermoluminescent dosimeter (TLD) response requires verifying that signal fading—defined by a reduction in stored signal—is well-known and corrected for under the...

Evaluating the Impact of Spot Spacing on Dosimetric Outcomes in Dynamic Arc Proton Therapy for Prostate SBRT

Authors: Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Umesh Rana, Hina Saeed, Nishan Shrestha, Somol Sunny

Affiliation: Florida Atlantic University, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: DynamicARC is a novel pencil beam scanning (PBS) proton therapy technique with the potential to provide more conformal dose distributions and reduce treatment time. This study investigates th...

Evaluating the Impact of an Average Versus Machine-Specific Dosimetric Leaf Gap on Dose Calculation

Authors: Michael Ashenafi, Nicholas Becerra Espinosa, Mario Ramos Gallardo, Matthew Pacella, Sean M. Tanny

Affiliation: Department of Radiation Oncology, University of Rochester

Abstract Preview: Purpose: The newest version of a large commercial treatment planning system (TPS) has introduced a new physical MLC model. We compare the impact of using an averaged dosimetric leaf gap (DLG) value ve...

Evaluation of an Offline Adaptive CBCT Planning Workflow for Halcyon with Hypersight

Authors: Michelle Alonso-Basanta, Joshua Bryer, Lei Dong, Barbara Garcia, Elissa Khoudary, Brandon M. Koger, Taoran Li, Michael Salerno, Karen Tang, Boon-Keng Kevin Teo

Affiliation: University of Pennsylvania

Abstract Preview: Purpose: The Varian HyperSight imaging solution features a workflow for planning on CBCT images (CBCTp). This study evaluates the feasibility of CBCTp images in the setting of an offline adaptive plan...

Extremity Imaging with Cone-Beam CT (CBCT) Scanner Dedicated for Hip Imaging – What Are the Effective Doses?

Authors: Jeff Boob, Jaydev K. Dave, Tim Minch, Bhavyata Tanna

Affiliation: Dr. Ronald E. McNair Academic High School, Mayo Clinic, CurveBeam AI

Abstract Preview: Purpose: To compute effective doses associated with imaging of the extremities with a HiRise (CurveBeam AI, Hatfield, PA) cone-beam CBCT scanner specifically designed for weight-bearing imaging of the...

Field Output Correction Factors of Novel Shielded and Unshielded Silicon Diode Detectors

Authors: Mohamad Ahmad Alissa, Carson Brame, Damian Czarnecki, Olivier Evrard, Charbel A. Habib, Jeff Hildreth, Andy Murray, Andreas Schönfeld, Ann-Britt Schönfeld, David Towle, Gerd Wessing

Affiliation: CDT-West - Centrum fĂŒr Diagnostik und Therapie, Radiologie Vechta, Technische Hochschule Mittelhessen, MyMichigan Health, Sun Nuclear Corp., Mirion Technologies

Abstract Preview: Purpose: To characterize field output correction factors of novel shielded and unshielded silicon diode detectors.
Methods: Novel shielded and unshielded Silicon Diode Detectors (SDD) were characte...

Finding the Best Match of 4D-CT Phases to Delineate Volumes for Bgrt

Authors: Resat Aydin, Joseph Barbiere, Brett Lewis, Roland Teboh

Affiliation: HUMC, Hackensack University Medical Center

Abstract Preview: Purpose:
Accurately compensating for respiratory-induced tumor motion is critical in BgRT, where precise delineation of volumes ensures effective dose delivery. We propose an integrated approach th...

From Concept to Clinic: A Phase-Based Approach for Implementing Auto-Segmentation in Radiation Therapy

Authors: Elizabeth L. Covington, Robert T. Dess, Charles S. Mayo, Michelle L. Mierzwa, Dan Polan, Jennifer Shah, Claire Zhang

Affiliation: University of Michigan, Department of Radiation Oncology, University of Michigan

Abstract Preview: Purpose: Auto-segmentation improves contour consistency and standardization in radiation therapy but may introduce variations from current practices, potentially impacting treatment outcomes and toxic...

Growing As Leaders Together – Results from the Medical Physics Leadership Academy Fundamentals of Leadership Cohort Program

Authors: Ashley Cetnar, Emily Y. Hirata, Cassandra Stambaugh

Affiliation: University of California San Francisco, Tufts Medical Center, The Ohio State University - James Cancer Hospital

Abstract Preview: Purpose: To provide results from the first four years of the Medical Physics Leadership Academy (MPLA) Fundamental of Leadership Cohort program
Methods: The MPLA Cohorts program began with the Fund...

High Resolution Head Motion Correction Based on Pilot Tone Signals – a Calibration-Free Method

Authors: Cheng-Chieh Cheng, Jeffrey P Guenette, Yajun Li, Bruno Madore, Lei Qin

Affiliation: Brigham and Women's Hospital, National Sun Yat-sen University, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Pilot tone (PT), a compact RF sensor, has been integrated into clinical practice for motion detection. Prior studies proposed mapping PT signals to head positions using a calibration step tha...

Identifying Candidates for Endobronchial Valve (EBV) Treatment for Patients with Moderate to Severe Emphysema: Exploring the Use of Estimated Lung Elasticity Using a Biomechanically Based Model Derived from CT Image Data

Authors: Ryan Andosca, Peter Boyle, Grace Hyun Kim, Minji Victoria Kim, Michael Vincent Lauria, Michael F. McNitt-Gray, Gabriel Melendez-Corres, Jack Neylon, Brad Stiehl, Pang Yu Teng

Affiliation: David Geffen School of Medicine at UCLA, University of California, Los Angeles, UCLA Department of Radiology, Department of Radiation Oncology, University of California, Los Angeles, UCLA, Cedars-Sinai Medical Center

Abstract Preview: Purpose: Endobronchial Valves (EBV) are one of the few treatment options for patients with moderate to severe emphysema. Eligibility is typically assessed from CT image data analysis including Emphyse...

Image-Guided Adaptive Proton Therapy for Head and Neck Cancer Using a Novel Gantry-Less System

Authors: Philip Blumenfeld, Jon Feldman, Yair Hillman, Michael Marash, Aron Popovtzer, Alexander Pryanichnikov, Shimshon Winograd, Marc Wygoda, Vered Zivan

Affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), P-Cure Ltd./Inc., Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem

Abstract Preview: Purpose:
Image-guided adaptive proton therapy (IGAPT) allows tailored dose adjustments to account for anatomical and physiological changes during treatment. Recent efforts have developed a cost-eff...

Impact of Arc Number Variation on VMAT Lattice Radiotherapy Plans

Authors: Minbin Chen, Gang Liu, Manju Liu, Weiwei Sang, Pulin Sun, Mingyuan Ye, Fang-Fang Yin, Lihua Zhang, Haiming Zhu

Affiliation: Jiahui International Hospital, Radiation Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, The First People's Hospital of Kunshan

Abstract Preview: Purpose: This study aims to evaluate the effects of varying the number of arcs on treatment plans created using Volumetric Modulated Arc Therapy (VMAT) for Lattice radiotherapy (LRT).
Methods: Thre...

Impact of Computed Tomography Noise Reference Levels in a Pediatric Hospital

Authors: Samuel L. Brady, Joseph G. Meier

Affiliation: Cincinnati Childrens Hospital Med Ctr

Abstract Preview: Purpose:
To establish noise reference levels for our pediatric hospital.
Methods:
Water equivalent diameter (Dw) and image noise was automatically measured by using a global noise algorithm i...

Impact of Diacetylene Polymer Chemistry on Real-Time Radiochromic Film Dosimetry

Authors: Rohith Kaiyum, Ozzy Mermut, Alexandra Rink

Affiliation: Department of Medical Biophysics, University of Toronto, Department of Physics and Astronomy, York University

Abstract Preview: Purpose: To investigate the relationship between chemical features and real-time response to ionizing radiation dose of radiochromic diacetylene crystals.
Methods: A number of radiochromic diacetyl...

Impact of Time-of-Flight Reconstruction and Motion Correction on PET-Based Dosimetry in 90y Radioembolization for Hepatocellular Carcinoma

Authors: Spencer Behr, Joseph Grudzinski, Youngho Seo, Jaehoon Shin, Yiran Wang, Frederick J. Wilson

Affiliation: University of California San Francisco, University of California, San Francisco, Voximetry, Inc., Voximetry, Inc

Abstract Preview: Purpose: Voxel-level imaging-based dosimetry enables a significant improvement in accurate and personalized treatment planning in radiopharmaceutical therapy, potentially leading to optimized disease ...

Integrating Large Kernel Attention Mechanism into Deep Learning Model for Automatic and Auccrate Segmentation of Gross Tumor Volume in Lung Cancer Patients

Authors: Xuezhen Feng, Li-Sheng Geng, Haoze Li, Xi Liu, Tianyu Xiong, Ruijie Yang

Affiliation: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, School of Physics, Beihang University, School of Nuclear Science and Technology, University of South China, Department of Radiation Oncology, Peking University Third Hospital

Abstract Preview: Purpose: This study aimed to develop a deep learning-based algorithm for automatically delineate gross tumor volume (GTV) for lung cancer patients, alleviating the workload of radiologists and improvi...

Investigating the Multimodal Fusion Techniques to Improve Prediction Accuracy of Biochemical Recurrence of Prostate Cancer

Authors: Clint Bahler, Ruchika Reddy Chimmula, Harrison Louis Love, Oluwaseyi Oderinde, Courtney Yong

Affiliation: Purdue University, Department of Urology, Indiana University School of Medicine, Advanced Molecular Imaging in Radiotherapy (AdMIRe) Research Laboratory, School of Health Sciences, Purdue University

Abstract Preview: Purpose: Prostate cancer (PCa) is a common malignancy in men, and predicting biochemical recurrence (BCR) is crucial for guiding treatment decisions. Integrating multimodal data, including clinical, i...

Investigation of the Diagnostic Quality of Chest X-Rays Simulated from CT

Authors: Matthew R. Hoerner, Allison Shields

Affiliation: Yale University School of Medicine, Yale University

Abstract Preview: Purpose: To investigate the quality and clinical utility of chest x-rays synthesized from CT scans (sCXR).
Methods: Five helical chest CT exams were chosen for evaluation: this cohort represented a...

Investigations on Intensity-Modulated Proton Therapy Robust-Optimization Strategies and Their Dosimetric Effects on Head and Neck Cancers

Authors: Shen Fu, Zhangmin LI, Zuofeng LI, Yuanshui Zheng

Affiliation: GuangZhou Concord Cancer Center, Guangzhou Concord Cancer Center

Abstract Preview: Purpose: To investigate the influence of different robustness optimization strategies and parameters in proton therapy plans for head and neck tumors on target coverage and OAR (organ at risk) sparing...

Joint Optimization of Patient-Specific Range Modulators and Beam Intensities for Conformal Flash Proton Therapy

Authors: Hao Gao, Jiayue Han, Wangyao Li, Yuting Lin, Jufri Setianegara, Aoxiang Wang, Yanan Zhu

Affiliation: Department of Biomedical Engineering, Huazhong University of Science and Technology, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Proton therapy leverages Bragg-peak-based dose delivery to achieve ultra-high-dose-rate FLASH with patient-specific range modulators (PSRM). Current proton FLASH (pFLASH) planning typically i...

Learning from Failures – Case Studies into Failing Patient Specific Quality Assurance Plans

Authors: Christopher S. Melhus, Elizabeth Meyer, Cassandra Stambaugh

Affiliation: Tufts Medical Center

Abstract Preview: Purpose: To investigate the clinical treatment planning parameters that impact patient-specific quality assurance (PSQA) passing rates for hippocampal avoidance whole brain (HAWB) treatment plans.
...

Material Decomposition with Propagation-Based X-Ray Phase Contrast: A Comparison of Multi-Energy and Multi-Distance Imaging

Authors: Giavanna Luisa Jadick, Patrick J La Riviere

Affiliation: University of Chicago

Abstract Preview: Purpose: We assess two multi-measurement acquisition schemes for material decomposition with x-ray phase-contrast imaging (XPCI); demonstrating for the first time that multi-distance imaging can match...

Mid-Range Planning for Efficient and Robust Proton Arc Therapy

Authors: Mingli Chen, Xuejun Gu, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Zi Yang, Kangning Zhang, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: Delivery efficiency and robustness are critical in spot-scanning proton arc therapy (SPAT), yet the conventional use of redundant energy layers (ELs) prolongs switching times and reduces effi...

Multi-Center Diffusion-Weighted MRI Validation for 0.35T MR-Linac: A Repeatability and Reproducibility Study

Authors: Tess Armstrong, Nema Bassiri, Alonso N. Gutierrez, Michael Kasper, Natalia Lutsik, Eric Mellon, Kathryn E. Mittauer, Siamak P. Nejad-Davarani, Shyam Pokharel, Suresh Rana, Hui Wang, Joseph Weygand

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, Miami Cancer Institute, Baptist Health South Florida, ViewRay, Inc., Miami Cancer Institute, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida, Department of Radiation Oncology, University of Miami

Abstract Preview: Purpose: Radiation treatments on the MR-linac (MRL) enable daily acquisition of anatomical and physiological images for adaptive treatment planning. The apparent diffusion coefficient (ADC) estimated ...

Multicentric Characterization of Organ-Based Tube Current Modulation in Thoracic and Abdominopelvic Computed Tomography: A Dosimetric and Image Quality Study

Authors: Corentin Desport, Dominique Iacchetti, Nicolas Kien, Ramiro Moreno, Melodie Munier, Séléna Pondard

Affiliation: Fibermetrix, Alara Expertise, Alara Group

Abstract Preview: Purpose: To evaluate the efficiency of organ-based tube current modulation (OBTCM) in thoracic and abdominopelvic Computed Tomography (CT) for different radiology departments and manufacturers. This s...

Multiparametric and Low-Field MRI for Biomimetic MRI-Readable Gel Dosimeters

Authors: Kaitlyn M Betz, David Dunkerley, Eric Johnson, Kalina V Jordanova, Kathryn E. Keenan, Samuel D Oberdick, Gregory P. Penoncello, Stephen E Russek

Affiliation: Dept of Radiology, Stanford, University of Colorado School of Medicine, NIST, College of Wooster

Abstract Preview: Purpose: Examine use of low-field MRI and multiparametric analysis for 3D MRI-readable biomimetic gel dosimetry. Low-field MRIs are compact, inexpensive, and portable. They could be located within rad...

On Estimating Effective Doses Associated with Different Imaging Protocols for Weight-Bearing Imaging of the Hip with a Dedicated Cone Beam CT (CBCT) Scanner

Authors: Jeff Boob, Jaydev K. Dave, Tim Minch, Bhavyata Tanna

Affiliation: Dr. Ronald E. McNair Academic High School, Mayo Clinic, CurveBeam AI

Abstract Preview: Purpose: To estimate effective doses associated with different imaging protocols for hip imaging with a cone beam CT (CBCT) scanner specifically designed for weight-bearing acquisitions.
Methods: A...

On the Sensitivity Evaluation of End-to-End Test in Radiotherapy

Authors: Yussuf A. Abdelal, Sebastien A. Gros, Luke Layman, Anil Sethi

Affiliation: Stritch School of Medicine, Cardinal Bernardin Cancer Center, Loyola University Chicago, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago

Abstract Preview: Purpose:
End-to-end (E2E) test is a vital QA check of the overall radiotherapy process from simulation imaging to treatment delivery. Although clinical passing criteria are available, guidelines on...

Optimizing Atlas Counts for MRI-Guided Atlas-Based Autosegmentation of Swallowing Muscles in Head and Neck Radiotherapy

Authors: Zayne Belal, Rachel Drummey, Clifton David Fuller, Stephen Y. Lai, Brigid A. McDonald, Setareh Sharafi, Sonja Stieb, Kareem Abdul Wahid

Affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Hospital of the University of Pennsylvania, Department of Radiology, Johns Hopkins University, KSA-KSB, Cantonal Hospital Aarau, College Of Osteopathic Medicine, NOVA Southeastern University, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose:
Radiotherapy-induced dysphagia can significantly impair head and neck (H&N) cancer patients’ quality of life. Despite the dose-dependent relationship between radiotherapy and dysphagia, sw...

Optimizing Fractionation Schedules for De-Escalation Radiotherapy in Head and Neck Cancers Using Deep Reinforcement Learning

Authors: Zhongjie Lu

Affiliation: Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine

Abstract Preview: Purpose: Patients with locally-advanced head and neck squamous cell carcinomas(HNSCCs), particularly those related to human papillomavirus(HPV), often achieve good locoregional control(LRC), yet they ...

Optimizing Quality Assurance CT Frequency and Setup Uncertainty in Brain Proton Therapy Patients for Reduced Normal Tissue Dose

Authors: Rachel B. Ger, Heng Li, Anh Tran

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Proton therapy patients undergo quality assurance CT scans (QACTs) during treatment to verify dosimetric accuracy and utilize robustness scenarios for setup and range uncertainties. For intra...

Performance Evaluation of Patient Demographics Model-Based Liver Volumetry

Authors: Yasaman Anbari, Srinivas Cheenu Kappadath, Benjamin P. Lopez, Armeen Mahvash, Ali Yousefi

Affiliation: University of Houston, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Patient-demographics-model-based liver volumetry is well-established for determining the future liver remnant following hepatectomy. We used gold-standard CT liver segmentation to validate th...

Planning Study of Spatially Fractionated Radiotherapy (SFRT) for Treating Recurrent Glioblastoma Multiforme (GBM)

Authors: Hyunuk Jung, Fiona Li, Brian Marples, Michael Milano, Sean M. Tanny, Dandan Zheng, Yuwei Zhou

Affiliation: Department of Radiation Oncology, University of Rochester, University of Rochester Medical Center, University of Rochester

Abstract Preview: Purpose:
Recurrent GBM remains one of the most challenging cancers, with limited treatment options. We investigated potential planning parameters of SFRT, a novel radiotherapy technique that delive...

Post-Implant Dosimetry (PID) between 1D and 2D Cs-131 Seed Models for Post-Op Cavities in Recurrent GBM Patients

Authors: Cindy Pham, Anurag Sharma, John Starner, Ching-Ling Teng, Michael A. Trager, Gabriella Wernicke

Affiliation: Northwell, Northwell Health, Radiation Medicine, Northwell Health

Abstract Preview: Purpose: Precisely identifying orientation of implanted seeds on post-implant CTs is challenging. This research addresses the dosimetric uncertainties stemming from uncertainties in identifying seed o...

Predicting CBCT-Based Adaptive Radiation Therapy Session Duration Using Machine Learning

Authors: Leslie Harrell, Sanjay Maraboyina, Romy Megahed, Maida Ranjbar, Xenia Ray, Pouya Sabouri

Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), University of California San Diego

Abstract Preview: Purpose: Real-time adaptive radiation therapy (ART) dynamically modifies patients’ treatment plan during delivery to account for anatomical and physiological variations. Addressing ART planning time v...

Protocol for In Vivo Dosimetry Using Myoslchip System: Characterization and Clinical Application

Authors: Jeremy S. Bredfeldt, Daniel W. Cail, Maria A. Czerminska, Cindy I. Hancox, David Hu, Benjamin Karasko, Claire Keun Sun Park

Affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Brigham and Women's Hospital, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School

Abstract Preview: Purpose: To develop a robust clinical protocol for in vivo dosimetry in radiotherapy using the myOSLchip Optically Stimulated Luminescent Dosimeter (OSLD) system by performing characterization and eva...

Proton CT-Imaging and Radiography Using 3D-Detector with Plastic Scintillators for on-Board Proton Imaging

Authors: Salahuddin Ahmad, Imad M. Ali, Zaid Alkalani, Nesreen Alsbou

Affiliation: University of Oklahoma, University of Central Oklahoma, University of Oklahoma Health Sciences Center

Abstract Preview: Purpose: To design and evaluate a 3D-detector for proton CT-imaging and radiography, utilizing volumetric plastic scintillator detector exposed to high-energy therapeutic beams from proton therapy sys...

Proton Minibeam Radiotherapy: Commissioning, Treatment Planning, and Delivery

Authors: Stephen M Corner, Daiki Hara, Jiasen Ma, Robert W Mutter, Mark D. Pepin, Nicholas B. Remmes, Hok Seum Wan Chan Tseung

Affiliation: Mayo Clinic - Rochester

Abstract Preview: Purpose: Proton minibeam radiotherapy (pMBRT) is a form of spatially fractionated radiation therapy leveraging submillimeter beams to improve the therapeutic ratio. We report on collimator design, com...

Proton Pencil Beam Scanning Ultra-High Dose Rate 3D Lattice Radiotherapy: A Proof-of-Concept Flash Sfrt Study

Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng

Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...

Quality Assurance Program for Dual Energy Subtraction Imaging-Based Markerless Tumor Tracking

Authors: Hyejoo Kang, Andrew Keeler, Mathias Lehmann, Jason Patrick Luce, Ha Nguyen, John C. Roeske

Affiliation: Varian Imaging Laboratory, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago

Abstract Preview: Purpose: Markerless tumor tracking (MTT) using dual-energy (DE) subtraction imaging is being considered as a non-invasive method to track tumors during lung cancer treatment. Prior to clinical impleme...

Quantification of Global Dosimetry Audit Performance: Assessing the Sensitivity and Specificity of Dosimetry Audits to Establish Reciprocity Among Different International Clinical Trials Credentialing Organizations

Authors: Fre'Etta Brooks, Catharine H Clark, Patricia Diez, Peter B. Greer, Hideaki Hirashima, Rebecca M. Howell, Mohammad Hussein, Stephen F. Kry, Joerg Lehmann, Jessica Lye, Mitsuhiro Nakamura, Christopher L. Nelson, Rushil Patel, Christine Peterson, Julianne M. Pollard-Larkin

Affiliation: Kyoto University, The University of Texas MD Anderson Cancer Center, Radiotherapy Trials Quality Assurance Group, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Medical Physics & Biomedical Engineering, University College London, Metrology for Medical Physics, National Physical Laboratory, Austin Health, University of Washington Medical Center, University of Newcastle

Abstract Preview: Purpose: To assess the consistency of end-to-end dosimetry audits currently used by different international clinical trial QA organizations with the goal of harmonizing audits and reducing audit overl...

Quantifying the Impact of Tissue Inhomogeneities on Calculated Dosimetry within LDR Brachytherapy

Authors: Fatemeh Akbari, Deidre Batchelar, Luc Beaulieu, Nathan E. Becker, Juanita Crook, Dakota Mckeown, Matthew Jonathan Muscat, Rowan M. Thomson

Affiliation: Département de physique, de génie physique et d'optique, Université Laval, BC Cancer Agency, UBC, Carleton University, BC Cancer - Kelowna, BC Cancer

Abstract Preview: Purpose:
To study the effects of inter-seed attenuation and tissue inhomogeneities on dose-volume metrics of critical structures in prostate low-dose-rate (LDR) permanent seed implant brachytherapy...

Quantitative Image Review Metric for Vertebral Body Misalignment

Authors: Luis E. Fong de los Santos, Douglas John Moseley, Satomi Shiraishi, Cenji Yu

Affiliation: Mayo Clinic

Abstract Preview: Purpose: To quantitatively detect errors in vertebral body localization using normalized cross correlation (NCC)

Methods: Volumetric images of a thoracic end-to-end SBRT phantom with a removabl...

Radiation Sub-Segmentectomy in 90y Radioembolization: Post-Therapy Dosimetry, Treatment Response, and Pathological Necrosis

Authors: Guilherme Rosa Ferreira, Dan Giardina, John Karageorgiou, Chris Malone, Allan Thomas

Affiliation: Washington University School of Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine

Abstract Preview: Purpose: Radiation segmentectomy has become a primary strategy in 90Y radioembolization, with localized treated volumes that can include up to two liver segments. The goal is complete pathological nec...

Radiopharmaceutical-Free Assessment of Tumor Vasculature Condition in Particle Therapy By Means of Range-Verification PET: A Feasibility Rat Study

Authors: Go Akamatsu, Han Gyu Kang, Chie Seki, Hitomi Sudo, Hideaki Tashima, Chie Toramatsu, Hidekatsu Wakizaka, Iwao Yamaya, Taiga Yamaya

Affiliation: National Institutes for Quantum Science and Technology

Abstract Preview: Purpose:
Tumor oxygen status, which provides important information to optimize particle therapy, may constantly change during a treatment period of several weeks. However, it is impractical to perf...

Real-Time Proton and Carbon Ion Monte Carlo Dose Calculation through GPU-Acceleration and DL-Based Denoising Algorithms

Authors: Yankui Chang, Shijun Li, Xi Pei, Ripeng Wang, Xuanhe Wang, X. George Xu, Qing Zhang, Jingfang Zhao

Affiliation: University of Science and Technology of China, Shanghai proton and heavy ion center, School of Nuclear Science and Technology, University of Science and Technology of China, Anhui Wisdom Technology Co., Ltd.

Abstract Preview: Purpose:
This paper describes disruptive methods using both GPU-based MC simulation and deep-learning (DL)-based MC denoising algorithms, as well as clinical tests involving more than 560 patient p...

Remote Evaluation of Flash Beamlines for Electron, Proton, and MV Photons

Authors: Alexander Baikalov, Luke Connell, Nolan M. Esplen, Michele M. Kim, Stephen F. Kry, Emil Schueler, Hayden Scott, Ryan Sun, Paige A. Taylor, Uwe Titt

Affiliation: The University of Texas MD Anderson Cancer Center, University of Pennsylvania, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: to develop an affordable, portable device for accurately measuring FLASH dose rates from protons, electrons, and photons. 4 detectors were utilized to measure the temporal structure of proton...

Reproducibility of Target Position during Surface-Guided Breath-Hold Adaptive SBRT of Liver Cancer

Authors: Lili Chen, Xiaoming Chen, Chang Ming Charlie Ma, Joshua Meyer

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose: Fast CBCT (HyperSight) acquisition technique together with a surface-guided breath-hold (SGBH) would allow a better image quality for accurate target/organ delineation. It facilitates breath-...

Retrospective Analysis of Shape and Dosage Changes in Structures during Radiotherapy for Head and Neck Cancer Patients Based on Velocity

Authors: Daming LI, Jinsen Xie, Zhe Zhang

Affiliation: Peking University Shenzhen Hospital Radiotherapy Department, School of Nuclear Science and Technology, University of South China

Abstract Preview: Purpose: To analyze the actual doses received during radiotherapy for head and neck cancers (HNC) using Velocity, providing insights for adaptive radiotherapy decision-making.
Methods: Thirty-three...

Retrospective Evaluation of Combined Photon SBRT and Radium-223 SPECT Based Radiopharmaceutical Therapy Tumor Dosimetry in Clinical Trial Patient Cases

Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang

Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill

Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...

Robust Evaluation of the Pronumbra Immobilization System for Proton Therapy HN Treatment

Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey

Affiliation: Thompson Proton Center

Abstract Preview: Purpose: The CQ Medical kVue Pronumbra Head & Neck (HN) System is a new immobilization device for proton therapy. The mask includes 4 large knobs that attach to the board with built-in shims. These kn...

Robustness Evaluation of Dynamic Arc Proton Therapy: A Comparative Analysis of Small and Large Spot Sizes in Lung and Prostate Cancer Planning

Authors: Awens Alphonse, Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Hina Saeed, Gagandeep Saini, Nishan Shrestha, Somol Sunny

Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: This study evaluates the robustness of DynamicARC proton therapy plans for lung and prostate cancer, comparing small spot size (SS) and large spot size (LS) plans under nominal and worst-case...

Secondary Neutron Dosimetry of Cieds Exposed to Neutron-Producing Photon Radiation Therapy

Authors: Angela Gearhardt, Stephen F. Kry, Christopher Ryan Peeler, Julianne M. Pollard-Larkin

Affiliation: The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences; The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: A growing number of radiation therapy (RT) patients have cardiovascular implantable electronic devices (CIEDs). Patients with CIEDs must be carefully managed because the devices are susceptib...

Sources of Magnetic Susceptibility Artifacts in MR Imaging of the Jaw and Facial Nerves

Authors: Avneesh Chhabra, Zhiyue J. Wang, Qing Yuan

Affiliation: University of Texas Southwestern Medical Center

Abstract Preview: Purpose: Magnetic susceptibility artifacts from dental arches and hardware often compromise MRI neurography of jaw and facial nerves. This study aims to characterize these artifacts and provide insigh...

Spatial Variation and Dosimetry of X-Ray Contamination in Total Skin Electron Beam Therapy

Authors: William G. Breen, Dalton Griner, Scott C Lester, Joseph John Lucido, Beth A. Schueler, Jack C. Thull

Affiliation: Mayo Clinic

Abstract Preview: Purpose: Designing a total skin electron (TSE) beam therapy protocol requires finding the optimal balance between penetration depth, field uniformity, and x-ray contamination (XC). To better understan...

Synthetic Spheres: Ultrasound Image Quality Assessment with a Uniform Phantom

Authors: Ted Lynch

Affiliation: Sun Nuclear, a Mirion Medical Company

Abstract Preview: Purpose: A novel ultrasound quality assurance method is presented that constructs “synthetic spheres” at arbitrary locations within the image frame by combining correlation length measurements from a ...

Target Region-Specific Dose-Volume Parameters for Estimate of Brain Toxicity in Single-Isocenter Multiple-Metastases Linac-Based Stereotactic Radiosurgery

Authors: David L. Barbee, Jose R. Teruel Antolin, Jinyu Xue

Affiliation: NYU Langone Health

Abstract Preview: Purpose: This work introduces a method of regional dose evaluation of normal brain tissue using local target-specific evaluation and compares to global dose evaluation for linac-based single-isocenter...

Technical Feasibility and Accuracy of Dynamic Longitudinal Couch Motion during Beam Delivery

Authors: Chonthicha Bunchuailuea, David Geeler, Martin Sabel, Claas Wessels

Affiliation: Varian Medical Systems

Abstract Preview: Purpose: Elongated treatment sites, such as craniospinal treatments, pose multiple challenges in today’s practices, requiring multiple CBCTs for position verifications per fraction, which might increa...

Towards Optimal Target Dose Conformity and Dose Drop-Off: Evaluation of a New Optimization Approach for Biology-Guided Radiotherapy Treatment Planning

Authors: Grant Gibbard, Chunhui Han, An Liu

Affiliation: RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: To evaluate the efficacy of a new approach to streamline treatment planning for biology-guided radiotherapy (BgRT) of fluorodeoxyglucose (FDG)-avid bony lesions on a BgRT machine with real-ti...

Uncertainty in Contralateral Breast Dose Reconstruction for Breast Cancer Radiotherapy Patients in the United States between 1990 and 2012

Authors: Amy Berrington de Gonzalez, David Borrego, Rochelle Curtis, Gretchen L Gierach, Jae Won Jung, Choonik Lee, Choonsik Lee, Matthew Mille, Lene Veiga, Jacqueline Vo

Affiliation: University of Michigan, East Carolina University, Radiation Protection Division, Office of Radiation and Indoor Air, U.S. Environmental Protection Agency, National Cancer Institute, Institute of Cancer Research

Abstract Preview: Purpose: Radiotherapy is vital for treating breast cancer, but its long-term health effects remain a concern. Accurate dose reconstruction is crucial for evaluating risks in retrospective epidemiologi...

Use of Radiopaque Rectal Spacer for IGRT – a Preliminary Analysis of Alignment Accuracy and Interobserver Variability

Authors: Joseph A. Miccio, Nicholas J. Potter, Zain Siddiqui

Affiliation: Penn State Health Milton S. Hershey Medical Center

Abstract Preview: Purpose: Fiducial markers are the gold standard for prostate alignment during CT-based image-guided radiotherapy (IGRT). Radiopaque hydrogel rectal spacers reduce rectal toxicity by displacing the rec...

Using a-Si 1200 Epid Portal Dosimetry for VMAT Commissioning

Authors: Ryan Burri, Nazanin Hoshyar, Jerry W. McCoy, Yulin Song, Huma Syed

Affiliation: Bay Pines VA Medical Center

Abstract Preview: Purpose: The study aimed to streamline traditionally manual, iterative, and time-consuming VMAT commissioning process. The goal was to identify an optimal set of MLC dosimetric parameters that minimiz...

Validation and Benchmarking of Mirdct Software for Organ Dose Estimation in Routine CT Protocols

Authors: Jared Baggett, Wesley E. Bolch, Lukas M. Carter, Robert Joseph Dawson, Laura Dinwiddie, Gunjan Kayal, Adam Leon Kesner, Harry Marquis, Juan Camilo Ocampo Ramos, Stefan Wehmeier

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, University of Florida, MD Anderson

Abstract Preview: Purpose: Accurate organ dose estimation in computed tomography (CT) has gained attention due to the increasing global utilization of CT imaging. MIRDct, a specialized CT dosimetry software, has recent...

Variations in Automatic Dose Response Curves across Fluoroscope Types and Manufacturers for Abdominal Imaging

Authors: Hadley Anna DeBrosse, Edward J. Stafford, Kevin A. Wunderle

Affiliation: Ohio State University, The Ohio State University

Abstract Preview: Purpose: To investigate automatic dose response curves from fluoroscopes across multiple manufacturers for an abdominal imaging protocol.
Methods: ADRC response for multiple fluoroscopes were evalu...

Visualization of Irradiation Field in Carbon-Ion Therapy By Openpet: Preliminary Analysis of Clinical Data

Authors: Go Akamatsu, Hiroaki Ikawa, Yuma Iwao, Han Gyu Kang, Masashi Koto, Hideyuki Mizuno, Akram Mohammadi, Makoto Shinoto, Minoru Tajiri, Hideaki Tashima, Chie Toramatsu, Taiga Yamaya

Affiliation: National Institutes for Quantum Science and Technology

Abstract Preview: Purpose: In-beam positron emission tomography (PET), in which positron emitters produced through fragmentation reactions are visualized, is a practical method for range verification in particle therap...

When Protons Are Unavailable: Study of High Quality Knowledge-Based Planning Models for the Treatment of Unilateral Head and Neck Patients

Authors: Kenny Guida, Daniel Johnson, Wesley Tucker

Affiliation: University of Kansas Medical Center, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Intensity modulated proton therapy (IMPT) has emerged as a standard of care for unilateral head and neck (HN) cancers due to superior OAR sparing. With the increase of proton centers national...