Authors: Shifeng Chen, Mariana Guerrero, Brian A. Hrycushko, Kai Huang, Kai Jiang, Narottam Lamichhane, Paul M. Medin, Elizabeth Nichols
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Maryland School of Medicine, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Radiation Oncology, University of Maryland Medical Center
Abstract Preview: Purpose: Unloaded needle catheters, if not handled properly, pose a risk for channel misconnection in interstitial high dose rate (iHDR) brachytherapy. This study aims to investigate the dosimetric im...
Authors: Shari Damast, Svetlana Kuznetsova, Christopher J. Tien
Affiliation: Yale University School of Medicine, Department of Therapeutic Radiology, Yale University School of Medicine
Abstract Preview: Purpose: Current contour similarity evaluation approaches (Dice Similarity Coefficient, Mean Distance to Agreement) are limited to geometric agreement without assessment of ultimate dosimetric impact....
Authors: Rani Anne', Wenchao Cao, Yingxuan Chen, Wookjin Choi, Firas Mourtada, Yevgeniy Vinogradskiy
Affiliation: Thomas Jefferson University
Abstract Preview: Purpose: In-room mobile cone-beam CT (CBCT) is emerging to enhance high-dose-rate (HDR) brachytherapy workflow using on-demand imaging. However, metal artifacts from X-ray markers inside gynecological...
Authors: Indrin J. Chetty, Jing Cui, Mitchell Kamrava, Tiffany M. Phillips, Jennifer M. Steers, Brad Stiehl
Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center
Abstract Preview: Purpose: Auto-contouring for HDR interstitial brachytherapy can be confounded by large deformation in anatomy and image quality. Here we evaluated the performance of an AI-based auto-contouring softwa...
Authors: Larry A. DeWerd, Sean Jollota, Karen Rex Pius Vincent
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison
Abstract Preview: Purpose: Absolute measurements, often used to establish primary standards, offer lower measurement uncertainty. For 192Ir high-dose-rate (HDR) brachytherapy, the interim primary standard for air-kerma...
Authors: Anna Becker, Tomislav Bokulic, Mauro Carrara, Krzysztof Chelminski, Larry A. DeWerd, Alexis Dimitriadis, Benjamin Kellogg, Malcolm R. McEwen, Zakithi L.M Msimang, Mark J. Rivard, Thorsten Sander, Thorsten Schneider, Jamema Swamidas, Egor Titovich, Paula Toroi, Carlos E. de Almeida, Jacco de Pooter, Liset de la Fuente Rosales, Deborah G. van der Merwe
Affiliation: Radiation and Nuclear Safety Authority, University of Zagreb, National Physical Laboratory, IAEA, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Rio de Janeiro State University, Dosimetry Laboratory, Dosimetry and Medical Radiation Physics Section, Division of Human Health, International Atomic Energy Agency, Physikalisch-Technische Bundesanstalt, National Metrology Institute, University of the Witwatersrand, Dosimetry and Medical Radiation Physics Section, Division of Human Health, International Atomic Energy Agency, National Research Council, Warren Alpert Medical School of Brown University
Abstract Preview: Purpose: The recently published IAEA-TRS-492 international code of practice (CoP) aims at improving traceability, accuracy, and consistency in Brachytherapy Dosimetry. To assess current approaches to ...
Authors: Ivan M. Buzurovic, Matthew W. Jacobson, Marjan Khosravi
Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, University of Massachusetts Lowell, Department of Physics, Lowell, MA/Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology
Abstract Preview: Purpose: Annual quality assurance (QA) of high dose rate (HDR) brachytherapy (BT) gynecological (GYN) applicators is critical to ensure accurate and consistent source position and dose delivery. In th...
Authors: Michael Kudla, Stephanie Merkl
Affiliation: BC Cancer - Kelowna
Abstract Preview: Purpose: 3D modeling for 3D printed GYN high dose rate (HDR) brachytherapy templates can be a time-consuming, error-prone process. To simplify the creation these templates, a software application has ...
Authors: Amy Tien Yee Chang, Chi Wai Cheung, Tin Lok Chiu, Chen-Yu Huang, Chi Wa Kong, Pei-Xiong Li, Pak Hang Nam, Bin Yang, Siu Ki Yu
Affiliation: Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Medical Physics Department, Hong Kong Sanatorium and Hospital
Abstract Preview: Purpose: This study introduces BrachyPlanCheck, an independent Monte Carlo (MC)-based dose calculation tool for 192Ir brachytherapy retrospective study or algorithm commissioning.
Methods: BrachyPl...
Authors: Yibin Ling, Qihui Lyu, Ke Sheng
Affiliation: University of California Berkeley, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
High Dose Rate (HDR) brachytherapy enables radiation to concentrate on the tumor by sending the high-dose-rate radioactive source directly to the treatment site. On the other hand, the sha...
Authors: Milad BaradaranGhahfarokhi, Manuel A. Morales Paliza
Affiliation: Vanderbilt University Medical Center
Abstract Preview: Purpose: The purpose of this study was to commission Varian HDR surface applicators using a high-resolution diode array and film dosimetry. This work evaluates dosimetric characteristics of these appl...
Authors: Brett Bocian, Patrick James Jensen, Luis Augusto Perles, Christopher J. Tien
Affiliation: Yale University School of Medicine, University of Miami, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center
Abstract Preview: Purpose: Guidelines for dose prescriptions in endometrial cancer are based upon depth from the cylinder, traditionally 5 mm or 0 mm (i.e., surface). There are no current single-channel vaginal cylinde...
Authors: Zachary R. Grelewicz, Kevin C. Jones, Yixiang Liao, Andrew Ogilvy, Julius V. Turian
Affiliation: Rush University Medical Center
Abstract Preview: Purpose: To demonstrate the accuracy and QA application of a time-resolved 3D gamma camera, we measured the path traversed by the Ir-192 High-Dose-Rate (HDR) brachytherapy source passing through a rin...
Authors: Benjamin Haibe-Kains, Ruiyan Ni, Alexandra Rink
Affiliation: Department of Medical Biophysics, University of Toronto, University Health Network
Abstract Preview: Purpose: Accurate auto-segmentation for targets and organs-at-risk (OARs) using deep learning reduces the delineating time in radiotherapy. In high-dose-rate brachytherapy, specific clinical criteria ...
Authors: Lucy Jiang, Chengyu Shi
Affiliation: Department of Radiation Oncology, City of Hope Orange County, Amity Regional High School (10th Grade)
Abstract Preview: Purpose: Early-stage breast cancer is common among females, with typically high local tumor control rates (LCR). Brachytherapy is a common way to achieve LCR following surgery. However, the patients m...
Authors: Chase Cochran, Damodar Pokhrel, William St Clair
Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine
Abstract Preview: Purpose: Currently, intraocular disease is primarily treated via COMS-plaques brachytherapy. Various stereotactic approaches via photons/proton beam have also been implemented (CyberKnife/GammaKnife/p...
Authors: Woong Cho, Jin-Beom Chung, Moo-Jae Han, Sang Won Kang, Boram Lee
Affiliation: Department of Radiation Oncology, Seoul National University Boramae Medical Center, Department of Radiation Oncology, Seoul National University Bundang Hospital, Department of Radiation Oncology, Inha University Hospital
Abstract Preview: Purpose: This study aims to establish a digital quality assurance (QA) system for high-dose-rate (HDR) brachytherapy by evaluating self-developed polycrystalline semiconductor dosimeters (PSDs).
Me...
Authors: Dylan Richeson, Dorin A. Todor
Affiliation: Inova Schar Cancer Institute, Virginia Commonwealth University
Abstract Preview: Purpose: High dose-rate (HDR) brachytherapy is prone to errors that can lead to incorrect dose delivery and potential medical events. One common issue is applicator length discrepancies, either due to...
Authors: Yang Lei, Tian Liu, Ren-Dih Sheu, Meysam Tavakoli, Jing Wang, Kaida Yang, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Emory University
Abstract Preview: Purpose:
The study aimed to improve target and organ at risk (OAR) segmentation in low-dose-rate brachytherapy (LDR-BT) for prostate cancer treatment, by integrating clinical guidelines into deep l...
Authors: Olubunmi Odunola Aregbe, Clara Ferreira, Margaret Reynolds, David A. Sterling, Jianling Yuan
Affiliation: University of Minnesota, University of Minnesota Physicians, Department of Radiation Oncology, University of Minnesota, Minneapolis
Abstract Preview: Purpose: To analyze volume changes in the high-risk clinical target volume (HR-CTV) during high-dose rate (HDR) brachytherapy for cervical cancer patients. The study aims to evaluate the trend and cor...
Authors: Adnan Jafar, Xun Jia, Michael B. Roumeliotis
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University
Abstract Preview: Purpose: HDR brachytherapy (HDRBT) treatment planning is challenging due to the need for high-quality plans under time pressure, considering anatomy and applicator geometry. This study proposes an exp...
Authors: Himanshu Bhat, Bruce Lewis Daniel, Junghoon Lee, Michael B. Roumeliotis, Ehud J. Schmidt, Ravi Seethamraju, Khadija Sheikh, Pan Su, Akila N. Viswanathan
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Siemens Medical Solutions USA Inc., Stanford Medical School, Department of Cardiology, Johns Hopkins University
Abstract Preview: Purpose: To perform frequent MRI during EBRT and brachytherapy (BT) to evaluate RT-induced fibrosis and remnant tumor changes, identified using ultrashort echo-time (UTE) and multiparametric (mpMRI), ...
Authors: Hilary P Bagshaw, Mark K Buyyounouski, Serdar Charyyev, Xianjin Dai, PhD, Yu Gao, Thomas R. Niedermayr, Lei Xing
Affiliation: Department of Radiation Oncology, Stanford University
Abstract Preview: Purpose: Real-time transrectal ultrasound imaging is the gold standard for needle placement and treatment planning of real-time based-ultrasound-based high dose-rate (HDR) prostate brachytherapy. Cumu...
Authors: Bryan Bednarz, John M. Floberg, Joseph B. Schulz, Jordan M. Slagowski
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Radiation Oncology, Stanford University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: Catheter placement for high-dose-rate brachytherapy (HDR BT) is clinician dependent and potentially suboptimal for delivering simultaneous integrated boosts to intraprostatic gross tumor volu...
Authors: Alexei V. Chvetsov, Sunan Cui, Sunyoung Jang, Robert D. Stewart
Affiliation: University of Washington and Fred Hutchinson Cancer Center, Penn State College of Medicine, University of Washington
Abstract Preview: Purpose: To evaluate spatial variation of relative biological effectiveness (RBE) in COMS (Collaborative Ocular Melanoma Study) eye plaques with low energy 125I and 103Pd photon sources as a function ...
Authors: Pedro Derosa, Joseph P. Dugas, Neven Simicevic, Hsinshun Terry Wu
Affiliation: Louisiana Tech Univeristy, Willis Knighton Cancer Center, Willis-Knighton Cancer Center
Abstract Preview: Purpose: To design and implement a collaborative educational effort between a regional university and unaffiliated cancer center introducing medical physics to an unaware undergraduate population at a...
Authors: Amar K. Basavatia, Lee C. Goddard, Wolfgang A. Tomé, Christian Velten, Ping Yan, Ravindra Yaparpalvi, Maria Stefania diMayorca
Affiliation: Montefiore Medical Center
Abstract Preview: Purpose: High dose rate (HDR) brachytherapy planning is a high-risk procedure performed under significant time pressure, with human failure being the leading cause of error. To elevate training for me...
Authors: Mojtaba Behzadipour, Suman Gautam, Tianjun Ma, Ikchit Singh Sangha, Bongyong Song, William Song, Kumari Sunidhi
Affiliation: UC San Diego, Virginia Commonwealth University
Abstract Preview: Purpose: This study aims to develop a knowledge-based voxel-wise dose prediction system using a convolutional neural network (CNN) for high-dose-rate (HDR) prostate brachytherapy and to evaluate its p...
Authors: Jeffrey Andrews, Nathan E. Becker, Juanita Crook, Andrew Jirasek, Matthew Jonathan Muscat
Affiliation: UBC, BC Cancer Agency, BC Cancer
Abstract Preview: Purpose: To map dosimetry and imaging information to ultrasound and multi-parametric magnetic resonance (mpMR) guided trans-perineal core-needle biopsies, performed during two-fraction prostate high-d...
Authors: Michael G. Mitch, Csilla I. Szabo-Foster
Affiliation: National Institute of Standards and Technology
Abstract Preview: Purpose: The U.S. air-kerma strength standard for low-dose-rate (LDR) low-energy photon-emitting brachytherapy sources provides measurement traceability for calibrations at the AAPM Accredited Dosimet...
Authors: Sam Beddar, Brett Bocian, David B. Flint, Benjamin Abraham Insley, Patrick James Jensen, Rachael M. Martin Paulpeter, Joshua S. Niedzielski, Luis Augusto Perles, Reza Reiazi, Gabriel O. Sawakuchi
Affiliation: University of Miami, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Empyrean Medical Systems, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: The Harrison-Anderson-Mick (HAM) applicator is an Ir-192 High-Dose-Rate (HDR) intraoperative radiotherapy device. It features a silicone body with embedded catheters that guide the Ir-192 sou...
Authors: Palanisamy Karunanithi, Karthikeyan Perumal, Siva Subramanian Vadivel
Affiliation: Dr. Kamakshi Memorial Hospital
Abstract Preview: Purpose:
Recent advancements in high dose-rate (HDR) brachytherapy include the image guidance, new applicators, and dose calculation algorithms. Brachytherapy has steep dose gradient, hence relativ...
Authors: Akire Trestrail
Affiliation: University of Wisconsin
Abstract Preview: Purpose: To investigate the feasibility of using 125I as a HDR directional brachytherapy source.
Methods: Monte Carlo (MC) simulations were performed using the EGSnrc software toolkit. Dose rate di...
Authors: Cindy Pham, Anurag Sharma, John Starner, Ching-Ling Teng, Michael A. Trager, Gabriella Wernicke
Affiliation: Northwell, Northwell Health, Radiation Medicine, Northwell Health
Abstract Preview: Purpose: Precisely identifying orientation of implanted seeds on post-implant CTs is challenging. This research addresses the dosimetric uncertainties stemming from uncertainties in identifying seed o...
Authors: Fatemeh Akbari, Deidre Batchelar, Luc Beaulieu, Nathan E. Becker, Juanita Crook, Dakota Mckeown, Matthew Jonathan Muscat, Rowan M. Thomson
Affiliation: Département de physique, de génie physique et d'optique, Université Laval, BC Cancer Agency, UBC, Carleton University, BC Cancer - Kelowna, BC Cancer
Abstract Preview: Purpose:
To study the effects of inter-seed attenuation and tissue inhomogeneities on dose-volume metrics of critical structures in prostate low-dose-rate (LDR) permanent seed implant brachytherapy...
Authors: Francis A Asamoah, David D. Campos, Jordan A Holmes, Ke Colin Huang, Omar Ishaq, Sook Kien Ng, Arpan Prabhu, Edwin Quashie, Yong Yue
Affiliation: Indiana University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose: Evaluate a novel rectal spacer workflow with spacer injection during brachytherapy to streamline logistics, reduce hospital visits and costs, and compare the benefits of SpaceOAR Vue and Barr...
Authors: Robert A. Rodgers
Affiliation: Vanderbilt University School of Medicine
Abstract Preview: Purpose: Preparing for radioactive material (RAM) program audits or inspections can be stressful. A five-step method to ensure program compliance is described. This method is adaptable to implementing...
Authors: Tirthraj Adhikari, Timothy J Allen, Abdullah A. Alshreef, Clara Ferreira
Affiliation: Medical School Department of Radiation Oncology University of Minnesota, University of Minnesota, Loma Linda University Medical Center
Abstract Preview: Purpose: GammaTile Brachytherapy with 131Cs is an effective treatment for glioblastomas, offering local control with minimal radiation necrosis. While the line source model is preferred for dose distr...
Authors: Elizabeth K. Butker, Cara Cimmino, Jenna L. Fair, David Matthew Giles, Bruce Hershatter, Shadab Momin, Sagar Patel, John Pattaras, Kamran Salari Salari, Aaron Weiss
Affiliation: Department of Radiation Oncology and Winship Cancer Institute, Emory University, Emory University School of Medicine
Abstract Preview: Purpose: Prostate cancer patients may experience a local-only failure after radiation. While high-dose-rate (HDR) brachytherapy may have more favorable toxicity profile and cancer control compared to ...
Authors: Rajeev K. Badkul, Ronald C Chen, Ying Hou, Harold Li, Chaoqiong Ma, Jufri Setianegara
Affiliation: Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose:
Postimplant urinary toxicity is common in prostate low-dose-rate (LDR) brachytherapy. We developed a machine learning (ML) model to explore the correlation between spatial dose distributio...
Authors: Kim Creach, Kim Howard, Julius G. Ojwang, Richard A. Shaw, Neelu Soni
Affiliation: Mercy Hospital Springfield
Abstract Preview: Purpose: To present a standardized MRI-CT hybrid workflow for High-Dose-Rate (HDR) Image-Guided Adaptive Brachytherapy (IGBT) in cervical cancer, aligned with AAPM TG-303, as a model to assist with im...
Authors: Åsa K. Carlsson Tedgren, Taran Hellebust, Antonio Herreros, Jacob Johansen, Christian Kirisits, Panagiotis Papagiannis, Mark J. Rivard, Frank-Andre Siebert, Frank Verhaegen, Javier Vijande, Jan Wiersma, Marisol de Brabandere, Ruud van Leeuwen
Affiliation: UKSH, Campus Kiel, Klinik für Strahlentherapie (Radioonkologie), Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Radiation Physics, Department of Medicine and Health (IMH), Linköping University, Radiation Oncology Department, Hospital Clínic-Universitat de Barcelona, IDIBAPS, IFIC-UV, Radiation Oncology, Amsterdam UMC location University of Amsterdam, Department of Radiation Oncology, Radboud University Medical Center, Department of Oncology, Aarhus University Hospital, University Hospital Gasthuisberg, Dept. of Radiation Oncology, Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Department of Radiation Oncology (MAASTRO), GROW – School for Oncology and Reproduction, Maastricht University Medical Centre+, Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Warren Alpert Medical School of Brown University
Abstract Preview: Purpose: This study, which was carried out by the GEC-ESTRO BRAPHYQS working group, reports the increasing divergence between clinical reference air kerma rate (RAKR) measurements and vendor-provided ...
Authors: Kevin Albuquerque, Ti Bai, Yesenia Gonzalez, Brian A. Hrycushko, Zohaib Iqbal, Paul M. Medin, Shanshan Tang
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Cervical cancer remains one of the most common and significant gynecological (GYN) malignancies globally, often presenting at advanced stages where radiation therapy and high-dose-rate (HDR) ...
Authors: Clara Ferreira, Tomas Agustin Montenegro, Courtney C. Oare
Affiliation: University of Minnesota
Abstract Preview: Purpose: This work provides a simulated proof of concept for the use of intravitreal gold nanoparticle (AuNP) during eye plaque brachytherapy as a radiation shield to critical structures in the eye us...
Authors: Michael Baine, Yang Lei, Yu Lei, Ruirui Liu, Tian Liu, Jing Wang
Affiliation: Icahn School of Medicine at Mount Sinai, University of Nebraska Medical Center
Abstract Preview: Purpose: Accurate 3D deformable registration of MRI and ultrasound (US) is essential for real-time image guidance during high-dose-rate (HDR) prostate brachytherapy. However, MRI-US registration of th...