Authors: Dale W. Litzenberg, Ikechi S Ozoemelam, Rowan Paplanus, Michael Pillainayagam, Donald A. Roberts
Affiliation: University of Michigan, Oregon Health & Science University
Abstract Preview: Purpose: Clinical linear accelerators use dual foil scattering systems designed to achieve large uniform fields (up to 25×25cm²), which can reduce beam fluence by up to 93% compared to the unmodified ...
Authors: Luke Connell, Stephen F. Kry, Malcolm R. McEwen, Bryan R. Muir, James Renaud, Emil Schueler, Hayden Scott, Paige A. Taylor
Affiliation: National Research Council, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: To demonstrate the capability of a robust calorimeter to accurately determine the absorbed dose delivered by an electron FLASH beamline.
Methods: Electron FLASH beams of 6 MeV and 9 Me...
Authors: Ruirui Dong, Gernot Echner, Peter Haering, Clarence King, Carlos Murillo, Gavin Poludniowski, Nicholas Sammut, Joao Seco, Steffen Seeber, Maria Francesca Spadea, Elpida Theodoridou
Affiliation: KIT, Department of Physics and Astronomy, Heidelberg University, Karolinska Institutet, DKFZ, University of Malta
Abstract Preview: Purpose:
The goal is to develop the first benchtop X-ray FLASH system based on a conventional small animal irradiator. The small animal irradiator will be modeled using a Monte Carlo toolkit for bo...
Authors: Daisuke Kawahara, Yoichi Watanabe
Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, University of Minnesota Medical School
Abstract Preview: Purpose: To theoretically demonstrate that FLASH dose delivery leads to higher normal tissue sparing than conventional dose rates.
Methods: A two-component kinetic model was built for target and da...
Authors: Xu Cao, Wesley S. Culberson, Aleksandra Ilina, Kendall Jarvis, Brian W Pogue, Matthew Reed, William Scott Thomas, Nathaniel Van Asselt, Albert van der Kogel
Affiliation: University of Wisconsin: Madison, University of Wisconsin: Madison School of Veterinary Medicine, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin–Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose: While FLASH radiotherapy is known to reduce skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR). Currently it is not clear whether this ...
Authors: Beatriz Allyne Dia Carandang, Chitho P Feliciano, Teresa Sy-Ortin
Affiliation: Department of Physical Sciences and Mathematics, University of the Philippines Manila, Health Physics Research Section, Atomic Research Division, Department of Science and Technology-Philippine Nuclear Research Institute (DOST-PNRI), Graduate School, University of Santo Tomas
Abstract Preview: Purpose: To investigate the X-ray radiation-induced bystander effect (RIBE), where unirradiated cells mimic the responses of directly irradiated cells, in MCF-7 breast cancer cells in vitro to underst...
Authors: Xun Jia, Youfang Lai
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University
Abstract Preview: Purpose: Ultrahigh dose rate FLASH (>40 Gy/s) radiotherapy (RT) has attracted significant attention. The mechanism remains unclear, hindering clinical translation. This study investigated the behavior...
Authors: Denise Dunn, Scott R. Floyd, Tyler V. Kay, Anna Lynnette-Price, Eric L. Martin, Stepan Mikhailov, Taylor Nguyen, Mark Oldham, Victoria J. P. Radosova, Zachary J. Reitman, Ramona Rodriguiz, Andrew Thompson, William Wetsel, Seth Wilcox, Ying Wu
Affiliation: Duke University Mouse Behavior Core, Department of Physics, Duke University, Medical Physics Graduate Program, Duke University, Duke University Medical Physics Program, Duke University, Duke University Mouse Behavioral and Neuroendocrine Analysis Core Facility, Department of Radiation Oncology, Duke University Medical Center
Abstract Preview: Purpose: FLASH radiation therapy (RT) shows promise for reducing normal tissue damage, though its mechanisms remain unclear. Using an in-vivo model with the High Intensity Gamma-ray Source (HIGS) lina...
Authors: James Chun Lam Chow, Harry E Ruda
Affiliation: University of Toronto, Princess Margaret Cancer Centre
Abstract Preview: Purpose: FLASH radiotherapy (FLASH-RT) with dose rate greater than 40 Gy/s, has demonstrated potential in reducing normal tissue toxicity while maintaining tumor control. However, accurate and reliabl...
Authors: Rafael Carballeira, David J. Gladstone, Philippe Liger, Rongxiao Zhang
Affiliation: TheryQ, Dartmouth College, University of Missouri, Thayer School of Engineering, Dartmouth College
Abstract Preview: Purpose: To model a FLASH electron beam system (FLASHLAB) via first principle Monte Carlo methods, navigating installation configurations, shielding and regulatory radiation safety considerations for ...
Authors: Deng-Yuan Chang, Matthew L. Scarpelli
Affiliation: Purdue University
Abstract Preview: Purpose: Tumor-associated macrophages (TAMs) can be assessed by Ferumoxytol-MRI in breast cancer because they are negatively correlated with the prognosis of patient outcome. However, some studies hav...
Authors: Paolo Pellicioli, Mohammad Rezaee, Ehsan Tajikmansoury, John W. Wong
Affiliation: Institute of Anatomy, University of Bern, Baltzerstrasse, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Abstract Preview: Purpose: Half-value layer (HVL) is a critical parameter for commissioning and quality assurance of preclinical x-ray irradiators. However, measuring HVL in cabinet systems presents challenges due to s...
Authors: Esteban Arzaga-Barajas, Paola Jazmin Guadarrama Huerta, Jose Alejandro Jimenez, Guerda Massillon-JL, Maria Adela Poitevin-Chacón, Alejandro Rodriguez-Laguna
Affiliation: UNAM, Medica Sur
Abstract Preview: Purpose: To perform patient-specific quality assurance (PSQA) tests for four SBRT treatments of patients diagnosed with vertebral, ilium, pelvic lymph node and lung tumors.
Methods: MAGIC gel consi...
Authors: Njood Alsaihati, Francesco Ria, Ehsan Samei, Justin B. Solomon, Martina Talarico, Jered Wells
Affiliation: Duke University, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System
Abstract Preview: Purpose: Radiation dose and associated risk in X-ray imaging is principally informed by patient size, further used in Computed Tomography (CT) to achieve prescribed image quality levels through tube c...
Authors: Jenghwa Chang, Chingyun Cheng, J Isabelle Choi, Muhammad Hamza, Minglei Kang, Tyler Kaulfers, Grant Lattery, Haibo Lin, Charles B. Simone, Xingyi Zhao
Affiliation: Peking University, Hofstra University Medical Physics Program, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Physics and Astronomy, Hofstra University, Physics Resident at Montefiore Einstein, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: In terms of high dose rate FLASH, the question remains on how to properly deliver treatment and what clinical sites are feasible to deliver such treatment. The novel Bragg peak (BP-FLASH) and...
Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Kathryn D Held, Nicolas Henthorn, Jay LaVerne, Thongchai Masilela, Stephen J. McMahon, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin, Michael Taylor, John Warmenhoven
Affiliation: Massachusetts General Hospital, Queen's University Belfast, Massachusetts General Hospital and Harvard Medical School, University of California San Francisco, University of Manchester, Notre Dame University
Abstract Preview: Purpose: TOPAS-nBio brings a cutting-edge Monte Carlo (MC) simulation framework to the research community to test hypotheses of radiation effects at the nanometer/cell scale. Here, we present the deve...