Authors: Rex A. Cardan, Richard A. Popple
Affiliation: University of Alabama at Birmingham
Abstract Preview: Purpose:
Compliance with TG 263 naming conventions for target structures in radiation oncology remains a challenging task due to the complexity and variability of the protocol. Traditional validati...
Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis
Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Womenâs Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute
Abstract Preview: Purpose: A challenge for dual energy CBCT is that noise and residual errors in material decomposition steps can become amplified when forming low energy, high contrast virtual mono-energetic images (V...
Authors: Suman Gautam, Tianjun Ma, William Song
Affiliation: Virginia Commonwealth University
Abstract Preview: Purpose: We propose an artificial intelligence (AI)-based method to rapidly predict the patient-speciïŹc quality assurance (PSQA) results for magnetic resonance (MR)-guided online adaptive radiation th...
Authors: Yu Chang, Mei Chen
Affiliation: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Abstract Preview: Purpose: Spot weights optimization, as a critical step in the proton therapy, is often time-consuming and labor-intensive. Deep learning, with its powerful learning and computational efficiency, can e...
Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Gregory Szalkowski, Qingying Wang, Kangning Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: Respiratory motion management is crucial for accurate radiation delivery to moving targets while protecting healthy tissue, relying on time-resolved volumetric imaging and continuous deformab...
Authors: Alonso N. Gutierrez, Daniel E. Hyer, Blake R. Smith
Affiliation: Miami Cancer Institute, Baptist Health South Florida, Iowa Health Care, University of Iowa
Abstract Preview: Purpose: To perform a feasibility study of optimizing and producing a compact range compensator to deliver single-energy pencil beam scanning (PBS) proton arc therapy treatments. Omitting energy chang...
Authors: Benito De Celis Alonso, Braian Adair Maldonado Luna, Gerardo Uriel Perez Rojas, RenĂ© Eduardo RodrĂguez-PĂ©rez, Kamal Singhrao
Affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Faculty of Physics and Mathematics, Benemérita Universidad Autónoma de Puebla
Abstract Preview: Purpose: Artificial Intelligence (AI)-generated synthetic CT (sCT) images can be used to provide electron densities for dose calculation for online adaptive MRI-guided stereotactic body radiotherapy (...
Authors: Wenhua Cao, Xianjin Dai, PhD, Hadis Moazami Goudarzi, Gino Lim, Miaolan Xie, Lei Xing, Lewei Zhao
Affiliation: University of Chicago Booth School of Business, Department of Radiation Oncology, Stanford University, Department of Industrial Engineering, University of Houston, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Proton Arc Therapy (PAT) delivers a continuous dose of radiation during gantry rotation. 4Ï is a non-coplanar technique used for advanced proton therapy delivery. This work proposes a hybrid ...
Authors: Jeffrey Bax, Ian A. Cunningham, Aaron Fenster, Lori Gardi, Sule Karagulleoglu Kunduraci, Alla Reznik, David Tessier
Affiliation: Robarts Research Institute, Imaging Research Laboratories, Robarts Research Institute, Lakehead University
Abstract Preview: Purpose: Image-guided biopsy is critical for early diagnosis of prostate cancer (PCa), the most common cancer in men worldwide. While the prostate-specific PET (P-PET) system offers enhanced sensitivi...
Authors: Alejandro Bertolet, Michael D. Farwell, Sarah Gitto, Victor V. Onecha, Daniel Pryma, Aladdin Riad
Affiliation: Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Department of Radiology, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Responses to ionizing radiation (IR) strongly correlate with the absorbed dose. At the cellular level, this is typically described by a linear-quadratic relationship provided the cell populat...
Authors: Katelyn M. Atkins, Indrin J. Chetty, Elizabeth M. McKenzie, Taman Upadhaya, Samuel C. Zhang
Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center
Abstract Preview: Purpose:
We explored a multi-regional and multi-omics approach to extract CT-based radiomics and 3D dosiomics features to predict radiation pneumonitis (RP) in patients with locally advanced Non-Sm...
Authors: Louis Archambault, Luc Beaulieu, Alexis Horik, Sajjad Ahmad Khan
Affiliation: Département de Physique, de Génie Physique et D'optique, et Centre de Recherche sur le Cancer, Université Laval, Département de physique, de génie physique et d'optique, Université Laval
Abstract Preview: Purpose: This study presents a novel 2D scintillation dosimeter leveraging long scintillating fibers for quality assurance (QA) in radiotherapy. The primary goal is to optimize critical parameters suc...
Authors: Hongyu An, Phillip Cuculich, H Michael Gach, Yao Hao, Trevor McKeown, Clifford Robinson, Yuhao Wang, Deshan Yang
Affiliation: Washington University School of Medicine in St. Louis, Washington University School of Medicine, Duke University, Department of Radiation Oncology, Duke University, Washington University in St. Louis, Department of Radiation Oncology, Washington University School of Medicine in St. Louis
Abstract Preview: Purpose: Cardiorespiratory motion management is crucial in stereotactic arrhythmia radiotherapy to define target margins and minimize cardiac toxicity. While respiratory 4DCT (r4DCT) images can infer ...
Authors: Yankun Lang, Lei Ren, Leshan Sun, Liangzhong Xiang, Yifei Xu, Jie Zhang
Affiliation: University of Maryland School of Medicine, University of California, Irvine
Abstract Preview: Purpose: To achieve the full-view image from a single-view sinogram using a two-stage deep learning model for electroacoustic-tomography (EAT), which is an emerging imaging technique with significant ...
Authors: David Brizel, Kyle J. Lafata, Jian-Guo Liu, Yvonne M Mowery, Yvonne M Mowery, William Paul Segars, Jack B Stevens
Affiliation: Department of Physics, Duke University, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Duke University, Department of Radiation Oncology, Duke University, University of Pittsburgh
Abstract Preview: Purpose: To develop a technique to quantify tumor topology using a unifying mathematical framework that integrates texture and morphology and to evaluate its feasibility as a prognostic biomarker for ...
Authors: Penghao Gao, Zejun Jiang
Affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Artificial Intelligence Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
Abstract Preview: Purpose: Real-time tumor tracking can effectively compensate for the impact of respiratory motion on dose distribution. We propose a patient-specific external-internal correlation model driven by opti...
Authors: Stephen R. Bowen, Chunyan Duan, Daniel S. Hippe, Qiantuo Liu, Jing Sun, Jiajie Wang, Shouyi Wang, Faisal Yaseen, Xiaojing Zhu
Affiliation: Tongji University, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Shanghai University of Electric Power, Fred Hutchinson Cancer Center, University of Texas at Arlington
Abstract Preview: Purpose: Accurate prediction of patient response to radiotherapy plays a crucial role in monitoring disease progression and assessing treatment efficacy, enabling clinicians to develop personalized th...
Authors: Walaa Abdelfadeel, Reagan Thomas Dugan, Tiffany Kinsey, Cameron Kofler, Zheng Feng Lu, Ingrid S. Reiser, Gregory Stacy, Sara Wallace
Affiliation: University of Chicago Medicine, University of Chicago
Abstract Preview: Purpose: To develop an accurate, vendor-neutral method for estimating geometric magnification at the plane of the hip joint on standing anterior-posterior (AP) radiographs for digital templating of to...
Authors: Zachary Buchwald, Zach Eidex, Richard L.J. Qiu, Justin R. Roper, Mojtaba Safari, Hui-Kuo Shu, Xiaofeng Yang, David Yu
Affiliation: Emory University and Winship Cancer Institute, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose: Gadolinium-based contrast agents (GBCA) are commonly used for patients with gliomas to delineate and characterize the brain tumors using T1-weighted (T1W) MRI. However, there is a rising conc...
Authors: Weigang Hu
Affiliation: Fudan University Shanghai Cancer Center
Abstract Preview: Purpose: The purpose of this study is to introduce a VQVAE-based framework that addresses the limitations of conventional dose prediction methods, which rely on fixed deep learning models that produce...
Authors: John P. Aris, Wesley E. Bolch, Robert Joseph Dawson, Bonnie N. C. President, Yitian Wang
Affiliation: Johns Hopkins University, University of Florida
Abstract Preview: Purpose: Generation of a mesh-based microscale lung model is essential for accurate dosimetry analysis. Lungs exchange air with the environment and may be exposed to alpha-particle-emitting radionucli...
Authors: Sean P. Devan, Cory S. Knill, Charles K. Matrosic, Zheng Zhang
Affiliation: University of Michigan
Abstract Preview: Purpose: Physicists troubleshooting machine issues during patient treatments often face high-pressure situations, balancing error codes, resource constraints, and time-sensitive decisions. To streamli...
Authors: Zilei Fu, Yi Guo, Wanli Huo, Hongdong Liu, Laishui Lyu, Zhao Peng, Yaping Qi, Senting Wang
Affiliation: Department of Radiotherapy, cancer center, The First Affiliated Hospital of Fujian Medical University, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University, Division of lonizing Radiation Metrology, National Institute of Metrology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, China Jiliang University, Department of Oncology, Xiangya Hospital, Central South University
Abstract Preview: Purpose: Medical image boundaries are commonly characterized by smooth gray-level transitions, resulting in pixel-level segmentation errors near these blurred boundaries. To address this, we developed...
Authors: Zachary Diamond, Pretesh Patel, Sibo Tian, Xiaofeng Yang, David Yu, Ahmal Jawad Zafar, Jun Zhou
Affiliation: Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose:
We propose a method to optimize adaptive proton FLASH therapy (ADP-FLASH) using modularized pin-ridge filters (pRFs) by recycling module pins from the initial plan, reducing pRF adjustment...
Authors: Kyle Cuneo, Issam M. El Naqa, Dale W. Litzenberg, Yiming Liu, Xueding Wang, Lise Wei, Wei Zhang, Jiaren Zou
Affiliation: University of Michigan, H. Lee Moffitt Cancer Center
Abstract Preview: Purpose: To quantitatively map 3D dose deposition during radiotherapy, empowering real-time adaptive radiation treatment.
Methods: The research features reconstructing dose deposition from acou...
Authors: Zachary Buchwald, Chih-Wei Chang, Zach Eidex, Richard L.J. Qiu, Mojtaba Safari, Shansong Wang, Xiaofeng Yang, David Yu
Affiliation: Emory University and Winship Cancer Institute, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose: MRI offers excellent soft tissue contrast for diagnosis and treatment but suffers from long acquisition times, causing patient discomfort and motion artifacts. To accelerate MRI, supervised d...
Authors: Ye Chen, Koki Kasamatsu, Taeko Matsuura, Taichi Murakami
Affiliation: Hokkaido University, National Institutes for Quantum Science and Technology (QST)
Abstract Preview: Purpose: In proton therapy, CT-based estimation of the stopping power ratio (SPR) is a significant source of range uncertainty. Protoacoustics have been developed to estimate the range in vivo, but fe...
Authors: Stephen D. Davis, Alonso N. Gutierrez, Noah S. Kalman, Yongsook C. Lee, Michael Leyva, Alejandro Rene Llanes Lopez, Carlos M. Rivera, Ranjini P. Tolakanahalli
Affiliation: Miami Cancer Institute, Baptist Health South Florida, Miami Cancer Institute, Miami Cancer Institute, Baptist Health
Abstract Preview: Purpose: Accurate treatment time calculation is a critical component of superficial radiotherapy (SRT), particularly for the SRT-100 Vision, where dose delivery depends on applicator geometry, treatme...
Authors: Sijuan Huang, Zi LIU, Jing MA, Xin Yang
Affiliation: Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, 510060, China
Abstract Preview: Purpose: To reduce the pressure of manual review of abnormal situations in manually/automatically delineated regions of interest (ROI), improve its accuracy and basis.
Methods: 220 radiotherapy pat...
Authors: Joyoni Dey, Hunter Cole Meyer, Murtuza Taqi
Affiliation: Louisiana State University
Abstract Preview: Purpose: We propose using super-resolution methods for X-ray grating interferometry without an analyzer with detectors that fail to meet the Nyquist sampling rate needed for traditional image recovery...
Authors: Zachary Carr, Katie W. Hulme, Zaiyang Long, Nathan A. Quails, Ashley Tao
Affiliation: Gundersen Health System, Ohio State University Wexner Medical Center, Mayo Clinic, Ohio State Wexner Medical Center, The Cleveland Clinic
Abstract Preview: Purpose: Meaningful interpretation of deviation index (DI) in clinical practice relies on appropriately set target exposure indices (EIT). EIT values for a given exam-view can be derived from the medi...
Authors: Quan Chen, Xue Feng, Chunhui Han, Gaofeng Huang, Trevor Ketcherside, Yi Lao, Yun Rose Li, An Liu, Bo Liu, Kun Qing, William T. Watkins
Affiliation: Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, Department of Radiation Oncology, City of Hope National Medical Center, Mayo Clinic Arizona, Carina Medical LLC
Abstract Preview: Purpose: New treatment platforms such as Ethos (Varian Medical Systems) allow the introduction of multi-modal imaging into adaptive radiotherapy workflow to facilitate an up-to-date view of patientsâ ...
Authors: Ramesh Boggula, Nikhil Jordan Shad
Affiliation: Wayne State University
Abstract Preview: Purpose: To evaluate the effectiveness of OpenAI in reviewing large volumes of radiation delivery reports from Mobius3D/FX. The goal was to assess whether automating this process could identify potent...
Authors: Hailun Pan, Yingli Yang, Jie Zhang, Yibin Zhang
Affiliation: Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Radiology, Ruijin Hospital, Department of Radiation Oncology, Ruijin Hospital, , Shanghai Jiaotong University School Of Medicine, Shanghai United imaging Healthcare Advanced Technology Research Institute
Abstract Preview: Purpose: Accurate patient positioning is critical in radiotherapy (RT) to ensure effective treatment delivery and minimize harming surrounding healthy tissues. Vertebral misalignment during RT setup h...
Authors: Laurence Edward Court, Raphael Douglas, David Fuentes, Anuja Jhingran, Barbara Marquez, Raymond Mumme, Christine Peterson, Julianne M. Pollard-Larkin, Surendra Prajapati, Dong Joo Rhee, Thomas J. Whitaker
Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Safe deployment of auto-contouring models requires the inclusion of automated quality assurance (QA). One approach is to use an independent auto-contouring model and compare the contours geom...
Authors: Majd Antaki, Rohini Bhatia, Gayoung Kim, Yosef Landman, Junghoon Lee, Akila N. Viswanathan
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Physics and Advanced Development Elekta
Abstract Preview: Purpose: Brachytherapy is a standard radiation therapy approach for cervical cancer, which directly delivers radiation source to the tumor using catheters. Treatment planning requires identification o...
Authors: Hua-Chieh Shao, Chenyang Shen, Jiacheng Xie, Shunyu Yan, You Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas
Abstract Preview: Purpose: Motion-resolved CBCT imaging, which reconstructs a dynamic sequence of CBCTs reflecting intra-scan motion (one CBCT per x-ray projection), is highly desired for regular/irregular motion chara...
Authors: Casey E. Bojechko, Lance C Moore
Affiliation: University of California, San Diego, University of California San Diego
Abstract Preview: Purpose: EPID images collected during treatment can serve as an in-vivo error detection mechanism. Previous works have shown that comparing in-vivo EPID images to AI-predicted EPID images for IMRT pla...
Authors: Cem Dede, Clifton David Fuller, Renjie He, Laia Humbert Vidan, Stephen Y. Lai, Amy Moreno, Mohamed Naser, Kareem Abdul Wahid, Natalie A West
Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Head and neck cancers (HNC) treated with radiation therapy can result in radiation-induced bone injury. In CT, changes in radiodensity correlate to changes in bone integrity. Most studies use...
Authors: Sam Beddar, Jason Michael Holmes, Daniel G. Robertson, James J. Sohn, Ethan D. Stolen
Affiliation: Department of Radiation Oncology, Mayo Clinic, MD Anderson Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Department of Radiation and Cellular Oncology, University of Chicago
Abstract Preview: Purpose: Camera-based scintillation dosimetry incorporating large volumes have shown promise for fast and comprehensive evaluation of external beam treatment fields. While some efforts have been made ...
Authors: Sen Bai, Guyu Dai, Dong Gao, Lecheng Jia, Guangjun Li, Yanfang Liu, Ying Song, Qing Xiao, Wei Zhang
Affiliation: United Imaging Healthcare, West China Hospital of Sichuan University, Shenzhen United Imaging Research Institute of Innovative Medical Equipment
Abstract Preview: Purpose:
Electronic portal imaging device (EPID) is currently the most widely used in-vivo dosimetry (IVD) device. However, the effective detector area shortage hinders further applications. This s...
Authors: Ergun E. Ahunbay, Colette Gage, Abdul Kareem Parchur, Eric S. Paulson
Affiliation: Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: AI-generated synthetic CT (sCT) images address challenges with prior sCT approaches, including atlas- and threshold-based methods. Commercial AI-based sCT tools have been introduced. This wor...
Authors: Sam Armstrong, Jamison Louis Brooks, Nicole Johnson, Douglas John Moseley, Cassie Sonnicksen, Erik J. Tryggestad
Affiliation: Mayo Clinic
Abstract Preview: Purpose: To evaluate the feasibility of a shallow learning-based quality assurance (QA) tool designed to assist human reviewers in assessing organ-at-risk (OAR) contours for head and neck radiotherapy...
Authors: Theodore Higgins Arsenault, Beatriz Guevara, Rojano Kashani, Raymond F. Muzic, Gisele Castro Pereira, Alex T. Price
Affiliation: University Hospitals Seidman Cancer Center, Case Western Reserve University Department of Biomedical Engineering
Abstract Preview: Purpose: Accurate dose prediction in radiotherapy is essential for treatment planning. This study evaluates four nnUnet-based models using the OpenKBP head and neck dataset: a baseline model (Model 1)...
Authors: Meghan Lubner, Krista McClure, Aria M. Salyapongse, Timothy P. Szczykutowicz, Giuseppe Toia, Ming Yan, Zhye Yin, Meghan Yue
Affiliation: GE HealthCare, Departments of Radiology and Medical Physics, University Wisconsin-Madison, GE Healthcare, University of Wisconsin-Madison, UW-Madison, University of Wisconsin Madison, Department of Radiology
Abstract Preview: Purpose: To evaluate virtual unenhanced (VUE) and true unenhanced (TUE) human subject images on a prototype deep silicon photon-counting detector (PCD) CT with prototype algorithms.
Methods: 5 subj...
Authors: Hao Peng, Yajun Yu
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) is a new treatment paradigm pioneered by our institution. But the early decision-making process in PULSAR is challe...
Authors: Fangfen Dong, Jiaming Li, Xiaobo Li, Weipei Wang, Zhixin Wang, Bing Wu, Benhua Xu, Yong Yang, Yifa Zhao
Affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital/Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors/Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematologi, Zhangpu County Hospital, School of Medical Imaging, Fujian Medical University
Abstract Preview: Purpose: To explore the construction and clinical application value of a deep learning-based positioning error prediction model, providing a reference for optimizing iSCOUT system-guided precision rad...
Authors: Xu Chen, Jun Lian, Yunkui Pang, Pew-Thian Yap
Affiliation: University of North Carolina at Chapel Hill, Huaqiao University
Abstract Preview: Purpose: Unsupervised CBCT-to-CT translation in the pelvic region is essential for accurate radiotherapy delivery and adaptive image-guided interventions. However, current models for cross-modality tr...
Authors: Derek Tang, Susu Yan
Affiliation: Massachusetts General Hospital
Abstract Preview: Purpose: To evaluate the performance of a multi-task automated-segmentation and synthetic CT generation model (sCT) and investigate its application in an adaptive proton therapy workflow.
Methods: ...
Authors: Hector Andrade-Loarca, Ines Butz, Chiara Gianoli, Prof. Gitta Kutyniok, Jianfei Li, Katia Parodi, Prof. Vincenzo Patera, Angelo Schiavi, Prof. Ozan Ăktem
Affiliation: Sapienza University of Rome, Department of Mathematics, Royal Institute of Technology, School of Computation, Information and Technology, Technische Universitaet Muenchen, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t MĂŒnchen (LMU Munich), Department of Mathematics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen
Abstract Preview: Purpose: To explore and demonstrate the feasibility of accurate and fast prediction of the water equivalent thickness (WET) distribution of tissue traversed by a proton imaging pencil beam, aiming at ...
Authors: Benjamin Haibe-Kains, Ruiyan Ni, Alexandra Rink
Affiliation: Department of Medical Biophysics, University of Toronto, University Health Network
Abstract Preview: Purpose: Accurate auto-segmentation for targets and organs-at-risk (OARs) using deep learning reduces the delineating time in radiotherapy. In high-dose-rate brachytherapy, specific clinical criteria ...
Authors: Fumiaki Komatsu, Shunsuke Moriya, Ryosuke Nakamura, Takeji Sakae, Toshiyuki Terunuma, Tetsuya Tomita
Affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Institute of Medicine, University of Tsukuba, Proton Medical Research Center, University of Tsukuba, Department of Radiology, University of Tsukuba Hospital
Abstract Preview: Purpose: To develop a deep learning (DL) model capable of accurately tracking lung tumors independent of beam angle variations.
Methods: A thoracic dynamic phantom simulating lung motion in the sup...
Authors: Xiaoyu Duan, Xiang Li, Wenbo Wan, Lei Zhang, Yiwen Zhang
Affiliation: Duke University, Medical Physics Graduate Program, Duke Kunshan University
Abstract Preview: Purpose: Breast screening has been proved to reduce breast cancer mortality by early detection and treatment for patients. Mammography is the most common and widely used technique for breast cancer sc...
Authors: Petr Bruza, Megan Clark, David J. Gladstone, Joseph Harms, Anthony E. Mascia, Brian W Pogue, Roman Vasyltsiv, Zhiyan Xiao, Rongxiao Zhang, Yongbin Zhang
Affiliation: Cincinnati Children's Proton Therapy Center, University of Missouri, Dartmouth College, Thayer School of Engineering, Dartmouth College, Washington University in St. Louis, University of Wisconsin - Madison
Abstract Preview: Purpose: With developing FLASH trials requiring diligent delivery monitoring, current proton therapy in-vivo dosimetry (IVD) cannot provide comprehensive verification, including dose and dose-rate vol...
Authors: Xinhui Duan, Roderick W. McColl, Mi-Ae Park, Liqiang Ren, Gary Xu, Kuan Zhang, Yue Zhang
Affiliation: UT Southwestern Medical Center, Department of Radiology, UT Southwestern Medical Center, Imaging Services, UT Southwestern Medical Center
Abstract Preview: Purpose:
Image-based deep-learning noise-reduction techniques have been developed for photon-counting CT (PCCT) to improve image quality with reduced radiation dose. The denoising strength is typic...
Authors: Mustafa Bashir, Diana Kadi, Kyle J. Lafata, Jacob A. Macdonald, Mark Martin, Yuqi Wang, Marilyn Yamamoto
Affiliation: Duke University, Department of Radiation Oncology, Duke University, Department of Electrical and Computer Engineering, Duke University, Department of Radiology, Duke Unversity
Abstract Preview: Purpose: To develop a high-throughput, automated-data-interrogation pipeline for integrating imaging and clinical information to identify key determinants of liver volume (LV), enabling population-sca...
Authors: Michael Burke, David J. Carlson, Yiu-Hsin Chang, Huixiao Chen, Zhe (Jay) Chen, Emily A. Draeger, Dae Yup Han, Vanessa Hill, Ann-Teresa Jasman, John Kim, Svetlana Kuznetsova, MinYoung Lee, Daniel Longo, Henry S. Park, Adam Shulman, Lauren Tressel, Weili Zhong
Affiliation: Department of Therapeutic Radiology, Yale University School of Medicine
Abstract Preview: Purpose:
The complexity of biology-guided radiotherapy (BgRT), particularly with systems like RefleXion X1, necessitates robust pre-treatment quality assurance (QA) to ensure patient safety, treatm...
Authors: Wenchao Cao, Yingxuan Chen, Haisong Liu, Wenyin Shi, Wentao Wang, Lydia J. Wilson, Zhenghao Xiao
Affiliation: Thomas Jefferson University
Abstract Preview: Purpose: Multi-target stereotactic radiosurgery (SRS) planning poses challenges due to complex geometries, small target volumes, and steep dose gradients. Achieving a balance between target coverage a...
Authors: Guang-Pei Chen, Mi Huang, Haidy G. Nasief, Eric S. Paulson
Affiliation: Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: Recently, kV imaging has been integrated into the Accuray Radixact platform, facilitating online adaptive and scan-plan-treat workflows with helical delivery in the near future. In order to s...
Authors: Ming Chao, Hao Guo, Tenzin Kunkyab, Yang Lei, Tian Liu, Kenneth Rosenzweig, Robert Samstein, James Tam, Junyi Xia, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai
Abstract Preview: Purpose:
The aim of the study is to develop a trade-off prediction model to efficiently guide the treatment planning process for patients with stage III non-small cell lung cancer (NSCLC).
Metho...
Authors: Theodore Higgins Arsenault, Kenneth W. Gregg, Lauren E Henke, Rojano Kashani, Haley K Perlow, Alex T. Price, Atefeh Rezaei, Prashant Vempati, Runyon C. Woods
Affiliation: University Hospitals Seidman Cancer Center
Abstract Preview: Purpose: The HyperSight imaging feature on C-arm linacs(HS-CBCT) offers increased CT number accuracy over conventional on-board imaging. The C-arm geometry allows for noncoplanar treatments common to ...
Authors: Amar K. Basavatia, Sandeepan Ganguly, Lee C. Goddard, Wolfgang A. Tomé
Affiliation: Montefiore Medical Center
Abstract Preview: Purpose: To investigate the dosimetric impact of WGTG51-e Report 385, recently updated CoP for clinical electron beams. This study uses a chamber specific effective point of measurement (EPOM) shift t...
Authors: Min Su
Affiliation: Mount Sinai School of Medicine
Abstract Preview: Purpose: To evaluate dosimetric impact of patient setup yaw error to target coverage for pelvis/prostate radiation external beam IMRT-VMAT treatment.
Methods: 9 Pelvis/prostate IMRT-VMAT treatment ...
Authors: Min Su
Affiliation: Mount Sinai School of Medicine
Abstract Preview: Purpose: To evaluate dosimetric impact of target coverage and organ at risk (OARs) sparing for whole breast patient setup roll/yaw change in 3D-conformal radiotherapy.
Methods: 8 whole breast cases...
Authors: Daniel H. Bushe, Arthur Lalonde, Hoyeon Lee, Harald Paganetti, Brian Winey
Affiliation: Universite de Montreal, Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, University of Hong Kong
Abstract Preview: Purpose: Improving the precision and fidelity of daily volumetric imaging is essential for enabling adaptive proton therapy (APT). While cone-beam CT (CBCT) provides daily volumetric imaging, their ut...
Authors: Jingying Lin, Stevan Pecic, Strahinja Stojadinovic
Affiliation: University of Belgrade, The University of Texas Southwestern Medical Center
Abstract Preview: Purpose: This study aims to determine the magnitude of polarization-induced dosimetric error for EBT4 films at different scanning orientations, and to provide guidance on selecting appropriate regions...
Authors: Lei Ren, Jie Zhang
Affiliation: University of Maryland School of Medicine
Abstract Preview: Purpose: 4D-CBCT is valuable for imaging anatomy affected by respiratory motions to guide radiotherapy delivery. However, 4D-CBCT often has undersampled projections acquired in each respiratory phase ...
Authors: Lian Duan, Stephen F. Kry, Hunter S. Mehrens, Christine Peterson, Paige A. Taylor
Affiliation: The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center
Abstract Preview: Purpose: To develop predictive models for IROC SRS head phantom audits and to identify important factors influencing institutional performance.
Methods: The IROC SRS head phantom includes two TLDs ...
Authors: Rashmi Bhaskara, Oluwaseyi Oderinde
Affiliation: Purdue University
Abstract Preview: Purpose: This study proposes a novel approach to overcoming CBCT image quality limitations by developing an improved synthetic CT (sCT) generation method based on a CycleGAN architecture using Vision ...
Authors: Jacob S. Buatti, Kristen A. Duke, Malena Fassnacht, Neil A. Kirby, Parker New, Niko Papanikolaou, Arkajyoti Roy, Yuqing Xia, Michelle de Oliveira
Affiliation: The University of Texas San Antonio, UT Southwestern Medical Center, UT Health San Antonio
Abstract Preview: Purpose:
Quantifying and visualizing uncertainty is critical for building clinical trust in AI-generated dose distributions. This study evaluates Monte Carlo Dropout (MCD), Snapshot Ensemble (SE), ...
Authors: Emel Calugaru, Jenghwa Chang, Sean T Grace, Nicholas Harvey, Jessica Jung, Ching-Ling Teng
Affiliation: Northwell, Hofstra University, Hofstra University Medical Physics Program
Abstract Preview: Purpose: To evaluate the consistency of MRI distortion corrections across Northwell Health system and evaluate the necessity and importance of distortion QA for MRIs used for stereotactic radiosurgery...
Authors: Haleem Azmy, Robbie Beckert, Farnoush Forghani, Dean Hobbis, Dan Hong, Hyun Kim, Eric Laugeman, Silpa Raju-Salicki, Domenic Sievert
Affiliation: Washington University in St. Louis School of Medicine, WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Washington University School of Medicine, Wash U Medicine, Washington University in St. Louis
Abstract Preview: Purpose: A novel radiation therapy (RT) workflow has recently emerged with the advent of online adaptive RT systems, direct-to-unit (DTU). DTU utilizes online adaptive platforms (MR and CT based) to o...
Authors: Louis Archambault, Nicolas Drouin, Alexis Horik, Simon Thibault
Affiliation: Département de Physique, de Génie Physique et D'optique, et Centre de Recherche sur le Cancer, Université Laval, Département de Physique, de Génie Physique et D'optique, et Centre d'optique, photonique et laser, Université Laval
Abstract Preview: Purpose: To develop a novel type of real-time 3D dosimeter for the quality assurance of linear accelerators used in external beam radiotherapy.
Methods: An experimental setup was constructed using ...
Authors: Girish Bal, Thomas I. Banks, Bin Cai, Neil Desai, Aurelie Garant, Orhan Oz, Elizeva Phillips, Rameshwar Prasad, Chenyang Shen, Robert Timmerman
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical
Abstract Preview: Purpose: This study reports findings from the first-in-human imaging-only trial evaluating the feasibility of using the novel PET tracer 68Ga-PSMA-11 (Illuccix) to guide external beam radiotherapy on ...
Authors: Niels Bassler, Jonathan Bortfeldt, Carlos Granja, Guyue Hu, Margarita Kozak, Julie Lascaud, Kirsten Lauber, Grigory Liubchenko, Jasper Nijkamp, Cristina Oancea, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Brita Singers SĂžrensen, Matthias WĂŒrl
Affiliation: Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t MĂŒnchen (LMU Munich), Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital, Advacam
Abstract Preview: Purpose: To apply in-vivo proton radiography (pRad) to aid image registration and treatment plan refinement for a novel precision image-guided small animal proton irradiation platform.
Methods:...
Authors: Qianyi Xu, Inhwan Yeo
Affiliation: INOVA Schar Cancer Institute, Thomas Jefferson University
Abstract Preview: Purpose:
Four-dimensional computed tomography(4DCT) is prone to a geometrical error when respiration changes upon patient shift. 4DCT with a longer-length detector(16cm), uninvolving the shift, has...
Authors: Hamid Abdollahi Nasehabad, Mehrangiz Amiri, Mohammad Reza Deevband, Faraz Kalantari, Milad Peer-Firozjaei, Ali Shabestani Monfared, Ehsan Tajikmansoury
Affiliation: Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Department of Radiology, University of British Columbia, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, 1. Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Abstract Preview: Purpose:
Targeted radionuclide therapy (TRNT) with 213Bi- labeled radiopharmaceuticals is a promising approach in targeted alpha and beta therapy for cancer. This study aims to assess double-strand...
Authors: Rashmi Bhaskara, Shravan Bhavsar, Ananth Grama, Oluwaseyi Oderinde, Shourya Verma
Affiliation: Purdue University
Abstract Preview: Generating Synthetic Positron Emission Tomography from Computed Tomography using Lightweight Diffusion Model for Head and Neck Cancer
Purpose: To generate synthetic PET tumor avidity segments direc...
Authors: ChangSeon Kim, Andrew Lukban, Mario Serrano-Sosa, Nadia M. Vassell
Affiliation: Mount Sinai Beth Israel
Abstract Preview: Purpose: Commissioning of Flexitron HDR horizontal Leipzig applicators typically includes indirect or direct output verification, using a well chamber specific Revised Correspondence Factor (CFrev) or...
Authors: Manju Liu, Weiwei Sang, Yanyan Shi, Zhenyu Yang, Fang-Fang Yin, Chulong Zhang, Lihua Zhang, Rihui Zhang
Affiliation: Jiahui International Hospital, Jiahui International Hospital, Radiation Oncology, Duke Kunshan University, Medical Physics Graduate Program, Duke Kunshan University
Abstract Preview: Purpose: This study aims to transform cone-beam computed tomography (CBCT) images acquired from deep inspiration breath-hold (DIBH) breast cancer patients into high-fidelity synthetic CT (sCT) images....
Authors: James M. Lamb, Dishane Chand Luximon, Jack Neylon, Rachel Petragallo, Moritz Ritter, Timothy Ritter
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, ETH Zurich, VCU Health System, Department of Radiation Oncology, University of Colorado
Abstract Preview: Purpose: Anomalies in cone beam computed tomography (CBCT) radiotherapy image guidance can signal treatment deviations. Repetitive review of setup image registrations by humans is inefficient, prone t...
Authors: Hilary P Bagshaw, Mark K Buyyounouski, Serdar Charyyev, Xianjin Dai, PhD, Yu Gao, Thomas R. Niedermayr, Lei Xing
Affiliation: Department of Radiation Oncology, Stanford University
Abstract Preview: Purpose: Real-time transrectal ultrasound imaging is the gold standard for needle placement and treatment planning of real-time based-ultrasound-based high dose-rate (HDR) prostate brachytherapy. Cumu...
Authors: Marissa Brown, Geoffrey D. Clarke, Luke Norton
Affiliation: University of Texas Health Science Center at San Antonio
Abstract Preview: Purpose: To evaluate how different learning strategies affect convolutional neural network (CNN) estimates of the liver's intravoxel incoherent motion (IVIM) parameters.
Methods: A 3-stage U-Net wa...
Authors: Mahya Ahmadzadeh, Nagarajan Kandasamy, Keyur Shah, Gregory C. Sharp, Santhosh Vadivel, John MacLaren Walsh
Affiliation: Electrical and Computer Engineering Department, Massachusetts General Hospital, Emory University, Drexel University
Abstract Preview: Purpose: In image-guided radiotherapy (IGRT), cone beam CTs (CBCTs) suffer from distortions that degrade registration with planning CTs. While CycleGANs can generate synthetic CTs (sCTs) from CBCTs, e...
Authors: Vibha Chaswal, Stephen D. Davis, Alonso N. Gutierrez, Noah S. Kalman, Yongsook C. Lee, William Romaguera, Ranjini P. Tolakanahalli, D. Jay J. Wieczorek
Affiliation: Miami Cancer Institute, Baptist Health South Florida
Abstract Preview: Purpose: To report machine performance of our superficial radiation therapy unit (SRT-100 Vision, Sensus Healthcare, Boca Raton, FL) for the first three years after commissioning of the unit.
Metho...
Authors: Wookjin Choi, James M. Lamb, David Romanofski, David H. Thomas, Yevgeniy Vinogradskiy
Affiliation: Drexel, Department of Radiation Oncology, University of California, Los Angeles, Thomas Jefferson University
Abstract Preview: Purpose: To develop an intelligent Black Box Recorder for radiation therapy (RT) that monitors patient treatments using a vision language model.
Methods: The system captures synchronized screen rec...
Authors: Mark Anastasio, Hua Li, Zhuchen Shao
Affiliation: Washington University School of Medicine, University of Illinois Urbana-Champaign
Abstract Preview: Purpose: Ill-conditioned reconstruction problems in medical imaging, such as those arising from undersampled k-space data in MRI, can result in degraded image quality and clinical task-orientated perf...
Authors: Yukio Fujita, Syoma Ide, Fumiki Ito, Kei Ito, Satoshi Kito, Keiko Murofushi, Yujiro Nakajima, Yuhi Suda, Kentaro Taguchi, Naoki Tohyama, Fumiya Tsurumaki, Riku Watanabe
Affiliation: Komazawa University Graduate School, Komazawa University, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Abstract Preview: Purpose: Spine stereotactic body radiotherapy (SBRT) demands high precision due to the target's proximity to the spinal cord and steep dose gradients, which complicate treatment planning. Consequently...
Authors: Amanda J. Deisher, Andrew YK Foong, Witold Matysiak, Jing Qian, Xueyan Tang, Erik J. Tryggestad, Mi Zhou
Affiliation: Mayo Clinic
Abstract Preview: Purpose: Phase gating is commonly employed to mitigate the impact of tumor motion in radiotherapy. Due to the machine-specific time delay between triggering and radiation delivery, the triggering sign...
Authors: Justus Adamson, John Ginn, Yongbok Kim, Ke Lu, Trey Mullikin, Xiwen Shu, Chunhao Wang, Zhenyu Yang, Jingtong Zhao
Affiliation: Duke University, Duke Kunshan University
Abstract Preview: Purpose:
To develop a knowledge-based deep model for synthetic CT (sCT) generation from a single MR volume in frameless radiosurgery (SRS), eliminating the need for CT simulation prior to the SRS d...
Authors: Nesrin Dogan, Panagiota Galanakou, Robert Kaderka
Affiliation: University of Miami, Sylvester Comprehensive Cancer Center, University of Miami Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose:
To develop knowledge-based treatment planning (KBP) for volumetric modulated arc therapy (VMAT) in chest wall treatments with regional nodal involvement. Given the challenges posed due to ...
Authors: Ben Piacitelli, Celeste Winters
Affiliation: OHSU, Department of Diagnostic Radiology, Oregon Health & Science University
Abstract Preview: Purpose: To compare recovery coefficients measured with Lu-177 and Tc-99m with the goal of assessing accuracy of the Tc-99m surrogate method and comparing RC reproducibility between scanners of the sa...
Authors: Min Cheol Han, Jin Sung Kim, Seok Ho Lee, Gahee Son, Yongdo Yun
Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Hanyang University, Department of Integrative Medicine, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine
Abstract Preview: Purpose: This study aims to develop the MC-DOLCE, a Monte Carlo (MC)-based system capable of calculating physical and biological dose distributions, as well as linear energy transfer (LET) distributio...
Authors: Alanah M. Bergman, Marc W Deyell, Tania Karan, Jakob Marshall, Justin Poon, Devin Schellenberg, Steven Thomas, Richard Thompson
Affiliation: University of British Columbia, University of Alberta, BC Cancer
Abstract Preview: Purpose: A conservative approach to account for random errors due to intra-fraction cardiac and respiratory motion during cardiac radioablation (CR) is to define a margin equal to the amplitude of car...
Authors: Alyssa Capizzi, John J Dombrowski, Nabil N. Khater
Affiliation: Saint Louis University
Abstract Preview: Purpose: To evaluate a mask-less adaptable headrest (MAHR) prototype for head-and-neck IMRT designed to reduce random and systematic shifts of patientsâ setups. MAHR complements current image-guidance...
Authors: Anthony J. Doemer, Yimei Huang, Benjamin Movsas, Ellen Park, Mira Shah, Salim Siddiqui, Karen C. Snyder, Kundan S Thind, Bo Zhao
Affiliation: Henry Ford Health
Abstract Preview: Purpose: The 6 degrees-of-freedom (6-DoF) robotic couch is considered essential for linac-based stereotactic radiosurgery (SRS), particularly for irregularly shaped targets adjacent to critical organs...
Authors: Tess Armstrong, Nema Bassiri, Alonso N. Gutierrez, Michael Kasper, Natalia Lutsik, Eric Mellon, Kathryn E. Mittauer, Siamak P. Nejad-Davarani, Shyam Pokharel, Suresh Rana, Hui Wang, Joseph Weygand
Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, Miami Cancer Institute, Baptist Health South Florida, ViewRay, Inc., Miami Cancer Institute, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida, Department of Radiation Oncology, University of Miami
Abstract Preview: Purpose: Radiation treatments on the MR-linac (MRL) enable daily acquisition of anatomical and physiological images for adaptive treatment planning. The apparent diffusion coefficient (ADC) estimated ...
Authors: Caroline Cheney, Nicole M. Lafata, Zaiyang Long, Dustin W. Lynch, Erin B. Macdonald, Andy Madore, Douglas E. Pfeiffer, Colin Schaeffer, Alexander W. Scott
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, UVA Health, Duke University Health System, Mayo Clinic, Henry Ford Health, Boulder Community Health, Varian, Cedars-Sinai Medical Center
Abstract Preview: Purpose: This work evaluates the significance of performing established radiography automatic exposure control (AEC) tests by comparing testing methodology, outcomes, and failure rates across multiple...
Authors: Steve B. Jiang, Mu-Han Lin, Yu-Chen Lin, Austen Matthew Maniscalco, Dan Nguyen, David Sher, Xinran Zhong
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, UT Dallas
Abstract Preview: Purpose:
Sequential boost radiotherapy (RT) poses a challenge in allocating dose across multiple plans while protecting organs at risk (OARs). Clinicians must decide whether OAR sparing should occu...
Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose:
Deep learning-based automatic medical image segmentation is increasingly employed in clinical practice, significantly reducing manual workload. However, verifying segmentation results rema...
Authors: Wenchao Cao, Yingxuan Chen, Haisong Liu, Richard A. Popple, Wenyin Shi, Rodney J. Sullivan, Wentao Wang, Lydia J. Wilson, Zhenghao Xiao
Affiliation: Thomas Jefferson University, The University of Alabama at Birmingham, University of Alabama at Birmingham
Abstract Preview: Purpose: Objectively evaluating brain sparing as a plan-quality indicator for patients receiving stereotactic radiosurgery (SRS) to multiple metastases (multi-met) is complicated by variability in tar...
Authors: Shahed Badiyan, Girish Bal, Thomas I. Banks, Bin Cai, Tu Dan, Aurelie Garant, Andrew R. Godley, Steve Jiang, Orhan Oz, Arnold Pompos, Rameshwar Prasad, Chenyang Shen, David Sher, Robert Timmerman, Kenneth Westover
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical
Abstract Preview: Purpose: Biology-guided radiotherapy (BgRT) is a novel FDA-cleared technology for treating lung and bone tumors based on 18F-FDG PET uptake. This study summarizes the first-year experience treating 29...
Authors: Ibtisam Almajnooni, Victor Cobilean, Milos Manic, Harindra Sandun Mavikumbure, Elisabeth Weiss, Lulin Yuan
Affiliation: Virginia Commonwealth University
Abstract Preview: Purpose: This study aims to optimize the 3D U-Net architecture for dose prediction in lung cancer radiation therapy (RT) plans, particularly in scenarios with limited clinical data, as well as to quan...
Authors: Hulya Ozdemir Buss, Jeffrey Geiger, Kim Howard, Julius G. Ojwang, Neelu Soni
Affiliation: Mercy Hospital Springfield
Abstract Preview: Purpose: The Radixact Synchrony system integrates real-time motion tracking and compensates to improve treatment accuracy for moving targets. This study presents a streamlined and efficient quality as...
Authors: James M. Balter, Lando S. Bosma, Jorge Tapias Gomez, Nishant Nadkarni, Mert R Sanbuncu, William Paul Segars, Ergys D. Subashi, Neelam Tyagi, Harini Veeraraghavan
Affiliation: University of Michigan, The University of Texas MD Anderson Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Cornell University, University Medical Center Utrecht, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Develop patient-specific virtual digital twin (VDT) cohorts modeling physically realistic spatio-temporal gastrointestinal (GI) organs (stomach and duodenum) digestive motion.
Methods: Pat...
Authors: Wouter Crijns, Frederik Maes, Loes Vandenbroucke, Liesbeth Vandewinckele
Affiliation: Department of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven; Department of Radiation Oncology, UZ Leuven, Department ESAT/PSI, KU Leuven; Medical Imaging Research Center, UZ Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven
Abstract Preview: Purpose: To explore intentional deep overfit learning (IDOL) to exploit the initial treatment plan to predict an adaptive radiotherapy plan.
Methods: A conditional generative adversarial network is...
Authors: Osama R. Mawlawi, Yiran Sun
Affiliation: RICE University, UT MD Anderson Cancer Center
Abstract Preview: Purpose: Conventional PET reconstruction methods often produce noisy images with artifacts due to data/model mismatches and inconsistencies. Recently, deep learning-based conditional denoising diffusi...
Authors: John Ginn, Zhuoyun Huang, Yongbok Kim, Ke Lu, Chunhao Wang, Yibo Xie, Zhenyu Yang, Jingtong Zhao
Affiliation: Duke University, Duke Kunshan University
Abstract Preview: Purpose: This study aims to develop and validate a machine learning model for predicting V60%, a critical dosimetric metric in LINAC-based Single-Isocenter-Multiple-Targets (SIMT) stereotactic radiosu...
Authors: Leslie Harrell, Sanjay Maraboyina, Romy Megahed, Maida Ranjbar, Xenia Ray, Pouya Sabouri
Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), University of California San Diego
Abstract Preview: Purpose: Real-time adaptive radiation therapy (ART) dynamically modifies patientsâ treatment plan during delivery to account for anatomical and physiological variations. Addressing ART planning time v...
Authors: Eric Aliotta, Michalis Aristophanous, Joseph O. Deasy, Bill Diplas, Milan Grkovski, James Han, Vaios Hatzoglou, Jeho Jeong, Nancy Y Lee, Ramesh Paudyal, Nadeem Riaz, Heiko Schoder, Amita Shukla-Dave
Affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: To forecast radiotherapy treatment response for head and neck cancer (HNC) using multimodality imaging and personalized radiobiological modeling.
Methods: Multi-modality imaging data from ...
Authors: Hua-Chieh Shao, You Zhang, Ruizhi Zuo
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose: Cone-beam CT (CBCT) provides on-board patient anatomy for image guidance and treatment adaptation in radiotherapy. However, to compensate for respiration-induced anatomical motion, motion-res...
Authors: Maria Jose Medrano, Grant Stevens, Liyan Sun, Justin Ruey Tse, Adam S. Wang, Sen Wang
Affiliation: Department of Radiology, Stanford University, GE HealthCare, Stanford University
Abstract Preview: Purpose: Patient exposure to ionizing radiation is a major concern in CT imaging. Size-specific dose estimation methods can prospectively estimate organ-level radiation doses based on patient sizes an...
Authors: Em Harkness, Francesco Ria, Ehsan Samei
Affiliation: Duke University, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System
Abstract Preview: Purpose:
A recently introduced mathematical method quantifies performance-based clinical risk to create a risk-to-risk assessment with radiation risk, rendering the so-called total risk. However, t...
Authors: Jon Burns, Andrew Groll, Gopinath Kuduvalli, Thomas Laurence, Manoj Narayanan, Jeffrey Schmall, Sanchit Sharma
Affiliation: RefleXion Medical
Abstract Preview: Purpose: To simplify BgRT testing we have developed techniques that use 3D resin printed structures that can be filled with Ge-68 epoxy. This approach allows the development of highly complex, clinica...
Authors: Steve B. Jiang, Dan Nguyen, Chenyang Shen, Fan-Chi F. Su, Jiacheng Xie, Shunyu Yan, Daniel Yang, Ying Zhang, You Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas
Abstract Preview: Purpose: Fast dose verification is essential for the safety and efficiency of MR-guided adaptive radiotherapy (ART) as patients anxiously waiting on the treatment couch. Conventional tools often requi...
Authors: Steve B. Jiang, Austen Matthew Maniscalco, Dan Nguyen, Chenyang Shen, Jiacheng Xie, Shunyu Yan, Ying Zhang, You Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas
Abstract Preview: Purpose: Although treatment planning systems (TPSs) can handle dose calculation and plan optimization automatically, planning for radiotherapy still requires extensive efforts and expertise from a mul...
Authors: Daisuke Kawahara, Takaaki Matsuura, Yuji Murakami, Ryunosuke Yanagida
Affiliation: Hiroshima High-Precision Radiotherapy Cancer Center, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima
Abstract Preview: Purpose: In recent years, automation in radiation therapy planning using AI has gained significant attention to reduce the workload of treatment planners. Adaptive Radiation Therapy (ART), as a new fo...
Authors: Courtney R. Buckey, Quan Chen, Suzanne J. Chungbin, Edward L. Clouser, Yi Rong, Jun Tan, Jennifer Yan, Xiang Sheng Yan
Affiliation: Mayo Clinic Arizona, Mayo Clinic
Abstract Preview: Purpose:
To identify planning techniques that consistently result in robust VMAT-TBI plans that allow for larger patient setup errors.
Methods:
Conventional planning method often results in p...
Authors: Hilary Louisa Byrne, Paul J. Keall, John Kipritidis, Jeremy Lim
Affiliation: Northern Sydney Cancer Centre, University of Sydney, Image X Institute, Faculty of Medicine and Health, The University of Sydney
Abstract Preview: Purpose:
Non-contrast CT ventilation imaging (CTVI) has been developed as a cost-effective and accessible alternative to PET/SPECT V/Q imaging for visualizing lung function. However, the sensitivit...
Authors: Joseph Barbiere, Joseph Hanley, Brett Lewis, Jay Mistry, Alois M. Ndlovu, Roland Teboh
Affiliation: Hackensack University Medical Center, HUMC, Jersey Shore University Medical Center
Abstract Preview: Purpose:
Quantitative PET-CT can evaluate clinical response to radiotherapy. For tumors less than approximately 3cm partial volume effects due to the poor PET resolution makes accurate measurement ...
Authors: Samuel Kadoury, Redha Touati
Affiliation: Polytechnique Montréal
Abstract Preview: Purpose:
Generating synthetic CT images from MR acquisitions for radiotherapy planning allows to integrate soft tissue contrast alongside density information stemming from CT, thus improving tumor ...
Authors: Hoyeon Lee
Affiliation: University of Hong Kong
Abstract Preview: Purpose: Deep-learning approaches are widely investigated for Cone-Beam CT (CBCT) scatter correction to improve the quality of the linear-accelerator mounted CBCT. This study aims to optimize the deep...
Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose:
This work demonstrates how existing software, when creatively adapted, can address a wide range of clinical challenges. By focusing on data exploration and application-specific modificatio...
Authors: Lawrence T. Dauer, Yusuf Emre Erdi, Yiming Gao, Dustin W. Lynch, Usman Mahmood
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Radiation dose to patients in CT examinations (CTDIvol, DLP) is tracked in dose monitoring solutions. Some solutions push for automatically estimating patient organ doses based on exam images...
Authors: Joana Antunes, Scott James Bright, David B. Flint, Mojtaba Hoseini-Ghahfarokhi, Mandira Manandhar, Poliana Marinello, Gabriel O. Sawakuchi, Tingshi Su
Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Laboratory of Instrumentation and Experimental Particle Physics; Faculty of Science of University of Lisbon, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, MD Anderson Cancer Center
Abstract Preview: Purpose: To study the accuracy of relative biological effectiveness (RBE) models to predict the RBE of a comprehensive panel of pancreatic cancer cell lines.
Methods: Clonogenic cell survival w...
Authors: Jeremy S. Bredfeldt, Benito De Celis Alonso, Braian Adair Maldonado Luna, Kevin M. Moerman, Gerardo Uriel Perez Rojas, RenĂ© Eduardo RodrĂguez-PĂ©rez, Kamal Singhrao
Affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Department of Mechanical Engineering, University of Galway, Faculty of Physics and Mathematics, Benemérita Universidad Autónoma de Puebla
Abstract Preview: Purpose: Online adaptive radiotherapy replanning for single-isocenter bone cancer metastasis treatment reduces on-table treatment time and patient discomfort compared to the multi-isocenter standard-o...
Authors: Darren Fang, Amar Kishan, Justin McWilliams, Dan Ruan, Xiaodong Zhong
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, Department of Radiology, University of California, Los Angeles, Department of Radiological Sciences, University of California, Los Angeles
Abstract Preview: Purpose: Prostate radiotherapy can malform penile vasculature, contributing to erectile dysfunction and compromising quality of life. To detect, quantify, and preferably avoid such occurrences, this p...
Authors: Jing Qian, Brandon Reber, David M. Routman, Satomi Shiraishi
Affiliation: Mayo Clinic
Abstract Preview: Purpose: The dose distribution in proton radiotherapy (PRT) is characterized by sharp gradients, posing a challenge for machine learning-based dose prediction. While denoising with diffusion processes...
Authors: Stephen R. Bowen, Shijun Chen, Chunyan Duan, Daniel S. Hippe, Qiantuo Liu, Qianqian Tong, Jiajie Wang, Shouyi Wang, Faisal Yaseen
Affiliation: The University of Texas at Austin, Tongji University, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Fred Hutchinson Cancer Center, University of Texas at Arlington
Abstract Preview: Purpose: Tumor subregion clustering and prediction of region-specific response can augment assessments and adaptive treatment decisions. A modeling framework was constructed to predict chemoradiation ...
Authors: Lu Jiang, Ke Sheng
Affiliation: Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Conventional radiotherapy treatment planning is guided by a set of generic objectives that are unspecific to patient anatomy. Treatment planning thus heavily relies on the plannerâs experi...
Authors: Guangjun Li, Ying Song, Huanan Tang, Tianxiong Wu, Qiuyi Ye, Wei Zhang
Affiliation: West China Second Hospital of Sichuan University, United Imaging Healthcare, West China Hospital of Sichuan University
Abstract Preview: Purpose:
To propose a general low-dose reconstruction model for ultra-sparse-view cone-beam CT (CBCT) and evaluate its clinical application in improving image quality and reducing radiation dose fo...
Authors: Laura I. Cervino, Wendy B. Harris, Paulo Quintero, Hao Zhang
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: To evaluate the impact of the prediction uncertainty from CBCT-based synthetic CT (sCT) generation in abdominal adaptive radiotherapy.
Methods: CT and CBCT images from 65 abdominal pat...
Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose:
Converting MR images to synthetic CT (MR2sCT) is highly desirable as it streamlines the radiotherapy treatment planning workflow. This approach leverages the superior soft tissue visibilit...
Authors: Ozgur Ates, Chin-Cheng Chen, Chia-Ho Hua, Matthew J. Krasin, Thomas E. Merchant
Affiliation: St. Jude Children's Research Hospital
Abstract Preview: Purpose: To validate the use of synthetic CTs generated from CBCT images for online monitoring, ensuring accurate and reliable daily plan quality assessments in adaptive proton therapy (APT).
Metho...
Authors: Harold Y Hu, Yanle Hu, Shuai Leng, Maryam Sadeghian, Joe Swicklik
Affiliation: Mayo Clinic Arizona, Basis Scottsdale, Mayo Clinic
Abstract Preview: Purpose: Radiotherapy CT simulation often requires two scans: a non-contrast scan for dose calculation and a contrast-enhanced scan for target delineation. Photon-counting-detector (PCD) CT allows the...
Authors: Caiden Atienza, Daniel E. Hyer, Samuel D. Rusu, Blake R. Smith, Joel J. St-Aubin
Affiliation: Iowa Health Care, University of Iowa
Abstract Preview: Purpose: Pinnacle3 TPS (Philips Radiation Oncology Systems, Fitchburg, WI, USA) support is set to end by December 31, 2026. This work presents a validated method to archive Pinnacle data, which may be...
Authors: Steve B. Jiang, Ruiqi Li, Hua-Chieh Shao, Kenneth Westover, You Zhang, Tingliang Zhuang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center
Abstract Preview: Purpose:
Respiratory motion is a long-standing challenge for lung SBRT, particularly for centrally-located lung tumors where increased toxicity demands more precise motion management during treatme...