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Results for "size distribution": 59 found

A Framework for Automated Selection of Dose-Volume Objectives to Improve Radiation-Induced Immune Suppression (RIIS)-Related Overall Survival (OS) Following Chemo-Radiotherapy

Authors: Gabriel Lucas Andrade de Sousa, Einsley-Marie Janowski, Cam Nguyen, Krishni Wijesooriya

Affiliation: Department of Radiation Oncology, University of Virginia, Department of Physics, University of Virginia

Abstract Preview: Purpose: Optimizing radiation therapy (RT) to spare the immune system may improve Overall Survival (OS) in cancer patients. This study develops a computational algorithm to identify optimal dose-volum...

A Multi-Regional and Multi-Omics Approach to Predict Penumonitis in Patients with Locally Advanced Non-Small Cell Lung Cancer in Nrg Oncology Trial RTOG 0617

Authors: Katelyn M. Atkins, Indrin J. Chetty, Elizabeth M. McKenzie, Taman Upadhaya, Samuel C. Zhang

Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center

Abstract Preview: Purpose:
We explored a multi-regional and multi-omics approach to extract CT-based radiomics and 3D dosiomics features to predict radiation pneumonitis (RP) in patients with locally advanced Non-Sm...

A Novel 2D Scintillation Dosimeter Using Long Scintillating Fibers.

Authors: Louis Archambault, Luc Beaulieu, Alexis Horik, Sajjad Ahmad Khan

Affiliation: Département de Physique, de Génie Physique et D'optique, et Centre de Recherche sur le Cancer, Université Laval, Département de physique, de génie physique et d'optique, Université Laval

Abstract Preview: Purpose: This study presents a novel 2D scintillation dosimeter leveraging long scintillating fibers for quality assurance (QA) in radiotherapy. The primary goal is to optimize critical parameters suc...

A Novel Semi-Analytic Approach for Dose Calculation in Proton Minibeam Radiotherapy

Authors: Hao Gao, Wangyao Li, Yuting Lin, Chao Wang, Wei Wu

Affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Proton minibeam radiation therapy (pMBRT) delivers a unique peak-and-valley dose pattern using collimators with narrow slits, offering improved normal tissue sparing compared to conventional ...

Accuracy Assessment of Bragg Peak Imaging Using Protoacoustics at a Clinical Dose

Authors: Michael Caulfield, Ye Chen, Yoshihiro Ishi, Yasutoshi Kuriyama, Taeko Matsuura, Naoki Miyamoto, Taichi Murakami, Tomonori Uesugi, Kohei Yokokawa

Affiliation: Hokkaido University, Kyoto University, University of Alberta

Abstract Preview: Purpose: Protoacoustics has the potential for real-time and direct imaging of the Bragg peak. This study investigated the accuracy of the Bragg peak imaging based on the water phantom experiment at a ...

Assessing Dose Enhancement and Shadowing Effects in Head and Neck Cases with Titanium Mandibular Implants

Authors: Sarah A. Ashmeg, Travis James McCaw, Joseph Shields, Matthew Spector, Christopher Tyerech, Christopher T Wilke

Affiliation: UPMC Hillman Cancer Center, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, UPMC Hillman Cancer Center, Department of Radiation Oncology, University of Pennsylvania, UPMC

Abstract Preview: Purpose: Patients with oral cavity cancer often undergo surgical extirpation prior to radiation, and surgical implants are utilized to reconstruct the resulting defect. This study dosimetrically evalu...

Assessing the Impact of Weighting Dose Volume Histograms By Variable Relative Biological Effectiveness for Radiation-Induced Lymphopenia Risk Prediction

Authors: Yan Chu, Madison Emily Grayson, Radhe Mohan, Pablo P. Yepes

Affiliation: UT Health Science Center at Houston, Rice University, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Radiation-induced lymphopenia (RIL) is a common adverse effect of radiation therapy, negatively impacting overall survival and anti-PD1 immunotherapy efficacy. Our lab previously developed a ...

Automated Classification of Treatment Sites from Physician Consult Notes Using a Large Language Model

Authors: Klea Hoxha, Dylan P. O'Connell, Ricky R Savjani

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, UCLA Radiation Oncology

Abstract Preview: Purpose: Ambiguities in physician simulation orders lead to workflow disruptions during CT simulation. Often, information that could provide
helpful context to simulation therapists and planners is...

Breastplan-Helper: Publicly Shared Source Scripting Toolset to Assist in 3D Breast Planning

Authors: Ryan Clark, Anthony Magliari, Luis Felipe Oliveira E Silva, Yang Sheng, Jason R Vickress, Qingrong Jackie Wu, Giulianne Rivelli Rodrigues Zaratim

Affiliation: Verspeeten Family Cancer Center, Office of Medical Affairs, Varian, A Siemens Healthineers Company, Confiar Radioterapia, Duke University Medical Center

Abstract Preview: Purpose: Develop a toolset to replace several of the tedious steps required to manually generate 3D breast treatment plans using static gantry forward planned tangent beams.

Methods: Eclipse Sc...

Commissioning of Varian HDR Surface Applicators Using High-Resolution Diode Array and Film Dosimetry

Authors: Milad BaradaranGhahfarokhi, Manuel A. Morales Paliza

Affiliation: Vanderbilt University Medical Center

Abstract Preview: Purpose: The purpose of this study was to commission Varian HDR surface applicators using a high-resolution diode array and film dosimetry. This work evaluates dosimetric characteristics of these appl...

Commissioning of a 3D-CRT Planning Software for a Machine with Only Flattening-Filter Free Energy

Authors: Michalis Aristophanous, Steven Blum, Laura I. Cervino, Antonio L. Damato, Karen Episcopia, Chi Huang, Shih-Chi Lin, Michelle K. Savacool

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Varian Ethos (Varian Medical Systems, Palo Alto, CA) is a 6 MV flattening-filter-free (FFF) only machine, posing a challenge in creating homogeneous dose distributions when using manual 3D-CR...

Compact Representation of External Beam Photon Phase Space Data Via Implicit Neural Representation Learning

Authors: Serdar Charyyev, Cynthia Fu-Yu Chuang, Veng Jean Heng, Lianli Liu, Lei Xing, Yong Yang

Affiliation: Department of Radiation Oncology, Stanford University

Abstract Preview: Purpose: To replace large finite-size photon phase space files with a compact neural network capable of generating an infinite number of particles.
Methods: Three separate models were developed to ...

Differential Hole-Size Lattice Patterns for Escalating SFRT Dose to Large, Deep-Seated, and Unresectable Masses

Authors: Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumor’s center, surrounded by smaller diameter spheres. W...

Dosimetric Impact of Calculation Grid Size in ZAP-X Stereotactic Radiosurgery

Authors: Michael Evan Chaga, Timothy Chen, Darra M. Conti, Shabbar Danish, Jing Feng, Wenzheng Feng, Joseph Hanley, Tingyu Wang

Affiliation: Hackensack Meridian Health, Jersey Shore University Medical Center

Abstract Preview: Purpose: ZAP-X is the newest cranial stereotactic radiosurgery (SRS) platform. Small-volume structures usually found in the head and neck may be susceptible to dose-volume averaging, which has not bee...

Dosimetric Impact of Catheter Length Changes in HDR Brachytherapy for Accelerated Partial Breast Irradiation

Authors: Dylan Richeson, Dorin A. Todor

Affiliation: Inova Schar Cancer Institute, Virginia Commonwealth University

Abstract Preview: Purpose: High dose-rate (HDR) brachytherapy is prone to errors that can lead to incorrect dose delivery and potential medical events. One common issue is applicator length discrepancies, either due to...

Evaluating the Impact of Reconstruction Algorithm on Wide-Angle Digital Breast Tomosynthesis System Optimization for Microcalcification Detection

Authors: Xiaoyu Duan, Xinyu Hu, Runqiu Li, Xiang Li

Affiliation: Dukekunshan University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
Accurate detection of small-sized microcalcifications (μCalcs) (< 500 µm) is critical for early breast cancer diagnosis, requiring optimal imaging systems and reconstruction algorithms. Ho...

Evolution of Log File-Based Patient-Specific QA across Multiple Linac Replacements

Authors: Gweneth Andersen, Colleen M. Foote, David (Bo) McClatchy, Hannah McFarland

Affiliation: Massachusetts General Hospital

Abstract Preview: Purpose: To quantify the impact of MLC model differences and LINAC age on treatment plan evaluation by log file-based patient-specific QA (PSQA) through the lifetime of the machines.
Methods: 3D ga...

Feasibility of Commercial Independent-Dose-Calculation for Pencil-Beam-Scanning Proton Therapy

Authors: Wen C. Hsi, Kayla Schneider

Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiation Oncology, University of Arkansas for Medical Sciences

Abstract Preview: Purpose:
Measurement-based patient-specific quality-assurance (PSQA) conducted with a 2D dosimeter to verify delivered dose of each field over 3 measurement-depths is time-consuming with limited se...

First-Time Live Imaging of Radiopharmaceutical Administration with a Hybrid Compton Camera

Authors: Ramesh Boggula, Jay W. Burmeister

Affiliation: Wayne State University, Karmanos Cancer Center, Gershenson ROC, Wayne State University School of Medicine

Abstract Preview: Purpose: This study evaluated the performance of a hybrid Compton camera for real-time imaging during the administration of Lu-177-based radiopharmaceuticals, including Pluvicto and Lutathera. The aim...

GPU Accelerated Monte Carlo Simulation for Tset Dose Calculation

Authors: Veng Jean Heng, Jan P. Seuntjens, Timothy C. Zhu, Yifeng Zhu

Affiliation: Department of Radiation Oncology, Stanford University, Princess Margaret Cancer Centre & University of Toronto, University of Pennsylvania

Abstract Preview: Purpose: We have developed a GPU-accelerated Monte Carlo (MC) simulation to determine the cumulative dose distribution of patients undergoing Total Skin Electron Therapy (TSET) using the Stanford tech...

Geographic Disparities in Medical Physics Training and Employment: Implications for Rural Workforce Recruitment

Authors: Seth Amofa, Erli Chen, Samuel A. Einstein, Ekinadoese Imudia Frias, Nupur Karmaker, Yinus Kawthara, Dulguun Myagmarsuren, Travis C. Salzillo, Joseph Weygand, Afua A. Yorke

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, University of Washington, Federal University Oye-Ekiti, Cheshire Medical Center, Dartmouth College, Penn State College of Medicine, Dept. of Medical Physics and Biomedical Engineering, Gono Bishwabidyalay, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Virginia Tech Carilion School of Medicine

Abstract Preview: Purpose: Recent developments in the medical physics job market have made it increasingly difficult for radiotherapy centers, particularly in rural areas, to recruit qualified therapeutic medical physi...

Gpt-Radplan: An Eclipse TPS Plugin for Automated Treatment Planning Based on Large Language Models

Authors: Peng Dong, Elizabeth Kidd, Sheng Liu, Thomas R. Niedermayr, Oscar Pastor-Serrano, Lei Xing, Yong Yang, James Zou

Affiliation: Department of Biomedical Data Science, Stanford University, Department of Radiation Oncology, Stanford University, Stanford University

Abstract Preview: Purpose: Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires iterative adjustments of optimization parameters to balance conflicting objectives. In thi...

Head and Neck Treatment Evaluation with Cone Beam Computed Tomotherapy

Authors: Varsha Jain, Jun Kang, Paul Sulivan, Kate E. Verma, Yevgeniy Vinogradskiy

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose:
Patients undergoing treatment for head and neck(H&N) cancers experience significant body contour changes throughout treatment. Body contour changes are due to tumor shrinkage, weight loss,...

Impact of Proton Beam Arrangements on LETd and RBE in Organs at Risk for Nasopharyngeal Cancer

Authors: Mauricio Acosta, Zachary Fellows, Alonso N. Gutierrez, Noah S. Kalman, Kristen A. McConnell, Rob Rohe, Andrew J. Wroe, Sreenija A Yarlagadda

Affiliation: Miami Cancer Institute, Baptist Health South Florida

Abstract Preview: Purpose:
Beam selection is crucial in proton therapy to ensure optimal physical and biological dose conformity to the target while maximizing sparing of normal tissue. This work investigates the im...

Impact of Tumor-to-Normal Ratio and Glass Microsphere Particle Density on Local Progression-Free Survival Following Lobar Yttrium-90 Radioembolization

Authors: Jason Chiang, Magnus Dahlbom, Veronica Hankil, Xinyi Li, Catherine (Caffi) Meyer, Kyung Hyun Sung

Affiliation: UCLA, University of California, Los Angeles

Abstract Preview: Purpose:
Yttrium-90 (90Y) radioembolization is a well-established therapy for large or multifocal liver tumors. Accurate dosimetry is critical but remains challenging, as low particle density risks...

Improve the Risk Prediction of Radiation-Induced Esophagitis in Lung IMRT By an Anisotropic Dose Convolution Neural Network

Authors: Ibtisam Almajnooni, Elisabeth Weiss, Lulin Yuan

Affiliation: Virginia Commonwealth University

Abstract Preview: Purpose: We developed a deep learning neural network (DLNN) to predict the risk of radiation-induced esophagitis (RE) during lung cancer radiation therapy based on the spatial dose distribution, for t...

Influence of Treatment Site on Lung Shunt Fraction Estimation in 90y-Radioembolization Planning: Comparison of Planar and SPECT Imaging-Based Quantification

Authors: Lukas M. Carter, Jazmin Schwartz

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Accurate lung shunt fraction (LSF) estimation is essential for the safety and efficacy of 90Y-radioembolization therapy. This study compares planar gamma camera imaging and tomographic SPECT-...

Investigating X-Ray Flash Effect on Plasmid DNA with Combined Microscopic Monte Carlo and Analytical Simulations

Authors: Xun Jia, Youfang Lai

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University

Abstract Preview: Purpose: Ultrahigh dose rate FLASH (>40 Gy/s) radiotherapy (RT) has attracted significant attention. The mechanism remains unclear, hindering clinical translation. This study investigated the behavior...

Investigation of Flash Proton Irradiation Induced DNA Double Strand Breaks Under Different Free Radical Scavenger Environments

Authors: Hansong Bai, Peter Jermain, Xun Jia, Heng Li, Devin Miles, Daniel Sforza, Michael H. Shang, Daniel Robert Strauss, Keith Unger, Lingshu Yin

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, MedStar Georgetown University Hospital, Johns Hopkins University, Department of Radiation Medicine, MedStar Georgetown University Hospital

Abstract Preview: Purpose: To investigate DNA Double Strand Break (DSB) induced by FLASH proton irradiation in a repair-free plasmid DNA model under different free radical scavenging conditions in plateau and Bragg pea...

Mapping Dosimetry, Excision Probability, and Mpmri Pixel Data to Core-Needle Biopsy Tissue from HDR Prostate Brachytherapy

Authors: Jeffrey Andrews, Nathan E. Becker, Juanita Crook, Andrew Jirasek, Matthew Jonathan Muscat

Affiliation: UBC, BC Cancer Agency, BC Cancer

Abstract Preview: Purpose: To map dosimetry and imaging information to ultrasound and multi-parametric magnetic resonance (mpMR) guided trans-perineal core-needle biopsies, performed during two-fraction prostate high-d...

Modeling Alpha-Particle Dose from Diffusing Alpha-Emitters Radiation Therapy in Tissue with Inhomogeneous Diffusion

Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang

Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...

Multi-Scale, Multi-Task Framework with Jacobian Descent for Multi-Plan Dose Prediction in Sequential Boost Radiotherapy

Authors: Steve B. Jiang, Mu-Han Lin, Yu-Chen Lin, Austen Matthew Maniscalco, Dan Nguyen, David Sher, Xinran Zhong

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center, UT Dallas

Abstract Preview: Purpose:
Sequential boost radiotherapy (RT) poses a challenge in allocating dose across multiple plans while protecting organs at risk (OARs). Clinicians must decide whether OAR sparing should occu...

Optimal Lattice Design for Spatially Fractionated Radiotherapy (SFRT) of Brain Metastasis in Gamma Knife (GK)

Authors: Brankica Andelic, Young-Bin Cho, Tara M. Gray, Andrew Robert Hadfield, Hakan Nordstrom

Affiliation: Elekta, Cleveland Clinic

Abstract Preview: Purpose: Spatially Fractionated Radiotherapy (SFRT) requires highly modulated dose distribution inside a tumor volume optimized using sets of planning structure of spheres in a lattice arrangement. To...

Optimization of Impulsed Acquisition Protocols on 1.5T MRI Using Simulation-Based Bayesian Experimental Design for Cell Size Imaging

Authors: Yan Dai, Jie Deng, Xun Jia, Wen Li, Junzhong Xu

Affiliation: Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiology, Vanderbilt University Medical Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Cell size is a vital parameter in evaluating the tumor microenvironment, including cell apoptosis and radiotherapy(RT)-induced immune cell infiltration. The IMPULSED(Imaging Microstructural P...

Optimizing Quality Assurance CT Scan Frequency in Proton Therapy: Reducing Excess Dose While Maintaining Treatment Accuracy

Authors: Curtiland Deville, Rachel B. Ger, Heng Li, Todd R. McNutt

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Proton therapy patients receive quality assurance CT scans (QACTs) during treatment to verify dosimetric accuracy and determine adaptive therapy needs as proton treatments are highly sensitiv...

Optimizing the Design for a Directional Brachytherapy Source

Authors: Akire Trestrail

Affiliation: University of Wisconsin

Abstract Preview: Purpose: To investigate the feasibility of using 125I as a HDR directional brachytherapy source.
Methods: Monte Carlo (MC) simulations were performed using the EGSnrc software toolkit. Dose rate di...

PET Guided Radiation Therapy for Large Planning Target Volume Expansions of Small PET-Active Gross Tumor Volumes

Authors: Sarah Dumont, Trevor Ketcherside, An Liu, William T. Watkins, Qiuyun Xu

Affiliation: RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose:
The RefleXion X1 SCINTIX algorithm convolves beam fluence with real-time PET distributions for tracking and plan adaptation, but radiotherapy Planning Target Volumes (PTVs) are often signi...

Parameterized Dosimetric Models of the Lumbar Vertebrae for Patient-Informed Active Marrow Dosimetry in Radiopharmaceutical Therapy

Authors: Wesley E. Bolch, Chansoo Choi, Robert Joseph Dawson, Michael Lassmann, Maikol Salas-Ramirez, Bangho Shin, Johannes Tran-Gia, Yitian Wang

Affiliation: Department of Nuclear Medicine, University Hospital Würzburg, University of Florida

Abstract Preview: Purpose: Conduct a parameterized library of mesh-type skeletal models across the lumbar vertebrae. In radiopharmaceutical dosimetry, the hematopoietic active bone marrow is typically a dose-limiting n...

Phantom-Based Dosimetric Comparison of Multiple CT Metal Artifact Reduction Algorithms for Head-and-Neck Radiotherapy

Authors: Loren Bell, Charles S Cathcart, Brett William Eckroate, Harold Y Hu, Joshua Kilian-Meneghin, Ke Nie, Fredrick Warburton, Zhenyu Xiong, Keying (Karen) Xu, Ning J. Yue, Yin Zhang, Lili Zhou

Affiliation: RWJBarnabas Health, Basis Scottsdale, Rutgers Cancer Institute of New Jersey

Abstract Preview: Purpose: This study compares the dosimetric impact of multiple metal artifact reduction (MAR) algorithms from different CT simulator vendors using an anthropomorphic head phantom for head-and-neck (H/...

Planning and Delivering Homogenous Dose to Craniospinal Irradiation on Linear Accelerator

Authors: Issra Rashed, Jennie Wilder, Jingeng Zhu

Affiliation: Rush Riverside Cancer Institute, Advanced Oncology Solutions (AOS) Varian, a Siemens Healthineers company

Abstract Preview: Purpose: Develop a method to plan and deliver homogeneous dose to Craniospinal(CS) irradiation on Linear Accelerator.
Methods: Three treatment planning volumes (PTV) are created in sequence from su...

Preclinical Assessment of Novel Targeted Chelate-Based Radiopharmaceuticals for Aggressive Cancer Detection

Authors: David Alcorta, Joseph Farina, Timothy Haystead, Yiping He, Philip Hughes, David Loiselle, Marybeth Nedrud, Victoria J. P. Radosova, Jianpeng Yu

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke University School of Medicine, Duke Cancer Institute

Abstract Preview: Purpose: Targeted radiopharmaceuticals have become of widespread interest in the scientific community given their ability to detect and treat metastatic disease. We aim to validate the use of novel ch...

Quality Monitoring of Temporal Performance Degradation in Clinical Use of AI Auto-Segmentation

Authors: Ali Ammar, Quan Chen, Jingwei Duan, Yi Rong, Nathan Y. Yu, Libing Zhu

Affiliation: Mayo Clinic Arizona, University of Alabama at Birmingham

Abstract Preview: Purpose: Clinical performance of deep learning-based auto-segmentation (DLAS) can degrade over time due to AI “aging” from unseen data input compared to the initial model training data. This study aim...

Quantifying the Impact of Tissue Inhomogeneities on Calculated Dosimetry within LDR Brachytherapy

Authors: Fatemeh Akbari, Deidre Batchelar, Luc Beaulieu, Nathan E. Becker, Juanita Crook, Dakota Mckeown, Matthew Jonathan Muscat, Rowan M. Thomson

Affiliation: Département de physique, de génie physique et d'optique, Université Laval, BC Cancer Agency, UBC, Carleton University, BC Cancer - Kelowna, BC Cancer

Abstract Preview: Purpose:
To study the effects of inter-seed attenuation and tissue inhomogeneities on dose-volume metrics of critical structures in prostate low-dose-rate (LDR) permanent seed implant brachytherapy...

Redesigning the CT Protocol Intranet: Solutions for Improved Access and User Engagement

Authors: Emi Ai Eastman, Vu Nguyen, Alexander W. Scott, Lucien Zang, Yifang (Jimmy) Zhou

Affiliation: Cedars-Sinai Medical Center

Abstract Preview: Purpose:
Three key features were developed to substantially improve a previously in-house developed CT protocol website: a structured backend for efficient protocol creation and edit; the ability t...

Reducing Variable Rbe in Oars for HN, Breast, and Prostate Proton Therapy Using a Scripted Spot-Delete Technique

Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey

Affiliation: Thompson Proton Center

Abstract Preview: Purpose: Linear energy transfer (LET) and variable relative biological effectiveness (RBE) evaluation are important steps in the future of proton therapy, moving beyond RBE=1.1 for all treatment plann...

Retrospective Planning Study for the Evaluation of Biological Effectiveness of Spatially Fractionated Radiation Therapy with Gamma-Knife Radiosurgery on Brain Metastases

Authors: Brankica Andelic, Young-Bin Cho, Tara M. Gray, Bingqi Guo, Andrew Robert Hadfield, Hakan Nordstrom, Jacob Scott, John Suh, Nara Yoon

Affiliation: Adelphi University, Elekta, Cleveland Clinic

Abstract Preview: Purpose: To investigate the biological effect of Spatially Fractionated Radiation Therapy (SFRT) within Gamma-Knife (GK) using retrospective planning for brain metastases patients. This study presents...

Robustness Evaluation of Aperture Shape Controller in Postmastectomy Radiotherapy of Breast Cancer Using Volumetric Modulated Arc Therapy

Authors: Yukio Fujita, Satoshi Ishikura, Fumiki Ito, Yujiro Nakajima, Takumi Sakamoto, Naoki Tohyama, Ryohei Yamauchi

Affiliation: Komazawa University Graduate School, St. Luke's International Hospital

Abstract Preview: Purpose: The aperture shape controller (ASC) is an Eclipse feature that increases muti-leaf collimator (MLC) aperture size. This study aimed to evaluate the effects of ASC settings on the robustness o...

Streamlined Proton Registry Interface for Patient Subtyping and Assessment Integration

Authors: Curtiland Deville, Rachel B. Ger, Elaina Hales, Heng Li, Todd R. McNutt

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Lack of specialized coding knowledge limits the use of data from large SQL repositories. We aimed to develop intuitive user interfaces for a registry that allows users to visualize the relati...

The Development of Large Field MR Guided Radiotherapy for Pelvic Lymph Node SBRT and Its Dosimetry Improvement

Authors: David Byun, Ting Chen, Paulina E. Galavis, Allison McCarthy, Hesheng Wang, Michael J Zelefsky

Affiliation: NYU Langone Health

Abstract Preview: Purpose: To summarize a MR guided adaptive workflow developed for pelvic lymph nodes (PLN) stereotactic radiotherapy using large field size on Elekta Unity© MR Linac system, and to quantitatively anal...

The Root Cause of Large Differences in Calculated Beam Monitor Units between a Treatment Planning System and a QA Software

Authors: George X. Ding, Kenneth L. Homann

Affiliation: Vanderbilt University Medical Center

Abstract Preview: Purpose: It is standard practice that the beam monitor units (MUs) calculated by a commercial treatment planning system (TPS) is verified by a secondary dose calculation (SDC) software that independen...

Towards Arbitrary Phantom Patient Specific IMRT QA on Reflexion X1

Authors: Andrew Groll, Ayan Mitra, PhD, Manoj Narayanan, Sanchit Sharma, Ray Yang, Timothy Pok Chi Yeung

Affiliation: Reflexion Medical Inc,, RefleXion Medical

Abstract Preview: Purpose: To develop a versatile QA tool enabling dose recalculation of a patient’s plan sinogram redeployed onto arbitrary replacement phantom geometry, and extract computed dose along detector planes...

Tracking Deposited Nanoparticle Cluster Sizes in Inhalation Based Nanoparticle-Enhanced Radiotherapy

Authors: Victoria Susan Ainsworth, Wilfred F. Ngwa, Erno Sajo

Affiliation: University of Massachusetts Lowell, Johns Hopkins University

Abstract Preview: Purpose: In nanoparticle-enhanced radiotherapy, the dose enhancement is function of the particle size. At therapeutic concentrations, the number density of nanoparticles gives rise to a high rate of i...

Use of Gold Nanoparticles As Shielding during Eye Plaque Brachytherapy

Authors: Clara Ferreira, Tomas Agustin Montenegro, Courtney C. Oare

Affiliation: University of Minnesota

Abstract Preview: Purpose: This work provides a simulated proof of concept for the use of intravitreal gold nanoparticle (AuNP) during eye plaque brachytherapy as a radiation shield to critical structures in the eye us...

Using Bayesian Analysis to Quantify the Impact of Clinical and Dosimetric Features for Predicting Swallowing Dysfunction in Oropharyngeal Cancer after Radiotherapy

Authors: Matthew D Blackledge, Christopher M. Nutting, Anju Mohanan Kaimal, Justine Tyler, Konstantinos Zormpas-Petridis

Affiliation: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, The Institute of Cancer Research

Abstract Preview: Purpose: Swallowing dysfunction (dysphagia) is a common side effect of radiotherapy for oropharyngeal cancer, significantly affecting patient's quality of life. This study aims to investigate the rela...

Using a Generative Adversarial Network (GAN) for Source Particle Generation in Monte Carlo Radiation Therapy Simulations

Authors: Jiankui Yuan, Dandan Zheng, Tingliang Zhuang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, University of Rochester, Varian Medical Systems, Advanced Oncology Solutions

Abstract Preview: Purpose: In Monte Carlo (MC) radiation therapy dose calculations, latent variance exists when directly applying phase-space files (PSF) with a finite number of source particles, while the latter is pr...

Utilization of Log File Analysis to Determine Deliverability of VMAT Plans As a Function of Plan Complexity

Authors: Jameson T. Baker, Sean T Grace, Cindy Pham, Michael A. Trager

Affiliation: Northwell

Abstract Preview: Purpose:
In VMAT planning, increasing complexity in MLC motion and modulation may improve dose distributions and OAR sparing while maintaining PTV coverage. However, increasing complexity can creat...

Utilizing All Acquired Images from Fluoroscopically-Guided Interventions: Test Application with Event-By-Event Patient Dosimetry Calculations

Authors: Sagine Berry-Tony, Lasya Daggumati, James R Duncan, Melak Senay, Allan Thomas

Affiliation: University of Missouri-Kansas City School of Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Washington University in St. Louis

Abstract Preview: Purpose: Most acquired images in FGIs are not permanently archived. In the context of modern computational prowess, novel improvements to FGI practice likely sit just under the surface of large-scale ...

What Do We Do with Our Old Pinnacle Data?

Authors: Caiden Atienza, Daniel E. Hyer, Samuel D. Rusu, Blake R. Smith, Joel J. St-Aubin

Affiliation: Iowa Health Care, University of Iowa

Abstract Preview: Purpose: Pinnacle3 TPS (Philips Radiation Oncology Systems, Fitchburg, WI, USA) support is set to end by December 31, 2026. This work presents a validated method to archive Pinnacle data, which may be...

dosimetric Characterization of Tungsten Eye Shields Using Monte Carlo Simulation

Authors: Omer Abdulaziz Ali, Robin Hill, Nathan Huntelerslag

Affiliation: Waikato Hospital, Hamilton, New Zealand, Central Coast Cancer Centre, Gosford, Australia

Abstract Preview: Purpose: Characterizing transmission through eye shields is essential to understanding dose distribution in underlying tissues. This study aims to utilize Monte Carlo (MC) simulations to model and cha...