Authors: Alejandro Bertolet, Michael D. Farwell, Sarah Gitto, Victor V. Onecha, Daniel Pryma, Aladdin Riad
Affiliation: Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Department of Radiology, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Responses to ionizing radiation (IR) strongly correlate with the absorbed dose. At the cellular level, this is typically described by a linear-quadratic relationship provided the cell populat...
Authors: Denis Bergeron, Ryan P Fitzgerald, Ravneet Kaur, Rao Khan
Affiliation: John Hopkins University, NIST Radiation Physics Division, Howard University, National Institute of Standards and Technology
Abstract Preview: Purpose: There is growing interest in short-lived alpha-emitting radionuclides for cancer therapy due to their ability to selectively target and destroy cancer cells while sparing healthy tissue. Howe...
Authors: Harsh Arya, Yan Chang, Yujie Chi, Varghese Anto Chirayath, Joshua Rajan, Pan Zui
Affiliation: University of Texas at Arlington, Department of Physics, University of Texas at Arlington
Abstract Preview: Purpose: In targeted alpha therapy (TAT), absorbed dose rates can vary significantly spatially and temporally, impacting therapeutic efficacy as well as carcinogenic potential. This study reports the ...
Authors: Jorge Naoki Dominguez Kondo, Qihui Lyu
Affiliation: University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose:
Targeted alpha therapy (TAT) has emerged as a highly potent therapeutic method in oncology, but its development is limited by the lack of imaging methods to quantify its dosimetry. Convent...
Authors: Lars R Furenlid, Chiao Huang, Matthew A. Kupinski, Brian W. Miller
Affiliation: University of Arizona, Departments of Radiation Oncology and Medical Imaging, University of Arizona
Abstract Preview: Purpose: To sample correlated k-constants in tissue-compartment model for pharmacokinetic study in targeted alpha therapy.
Methods: This work simulated the biodistribution of PSMA-11 tracers labele...
Authors: Hamid Abdollahi Nasehabad, Mehrangiz Amiri, Mohammad Reza Deevband, Faraz Kalantari, Milad Peer-Firozjaei, Ali Shabestani Monfared, Ehsan Tajikmansoury
Affiliation: Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Department of Radiology, University of British Columbia, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, 1. Department of Radiobiology and Medical Physics, Babol University of Medical Sciences, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Abstract Preview: Purpose:
Targeted radionuclide therapy (TRNT) with 213Bi- labeled radiopharmaceuticals is a promising approach in targeted alpha and beta therapy for cancer. This study aims to assess double-strand...
Authors: Magdalena Bazalova-Carter, Ross I. Berbeco, James Day, Xinchen Deng, Chelsea Amanda Saffron Dunning, Dianne M. Ferguson, Matthew W. Jacobson, Toby Morris, Marios Myronakis, Jericho Daniel O'Connell, Fides Schwartz, Jainil Shah, Aaron Sodickson
Affiliation: Brigham and Womens Hospital, University of Massachsetts Lowell and Dana-Farber Cancer Institute Boston, Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, University of Washington, University of Victoria, Siemens Healthineers, Dana Farber/Brigham and Women's Cancer Center, Brigham and Women's Hospital
Abstract Preview: Purpose: While CT imaging has advanced with improved machine design, we propose further gains can be achieved by enhancing sensitivity to contrast agents. Current CT sensitivity is limited to 1% bismu...
Authors: Vinay K Banka, Mikalai Budzevich, William R. Gibbons, Mark L. McLaughlin, Jacob Moriarty, Eduardo G. Moros, David L. Morse, Christopher J. Tichacek, Thad J. Wadas
Affiliation: Modulation Therapeutics Inc, Moffitt Cancer Center, University of Iowa
Abstract Preview: Purpose: A targeted alpha therapy drug, 225Ac-MTI-201, has been developed targeting the Melanocortin 1 Receptor for metastatic uveal melanoma and is currently in FIH clinical trials. Since alpha emiss...
Authors: Lars R Furenlid, Chiao Huang, Matthew A. Kupinski, Brian W. Miller
Affiliation: University of Arizona, Departments of Radiation Oncology and Medical Imaging, University of Arizona
Abstract Preview: Purpose: To sample random numbers of decay of radiotracers in a pharmacokinetic compartment model for Monte-Carlo simulation of imaging in targeted alpha therapy.
Methods: Time-activity curves (TAC...
Authors: Jonathon W. Mueller
Affiliation: Moffitt Cancer Center
Abstract Preview: N/A...