Authors: Carlo Greco, Joep Stroom, Sandra Vieira
Affiliation: Champalimaud Center for the Unknown
Abstract Preview: Purpose: RTP safety margins are generally based on geometrical uncertainties alone and not directly on clinical outcome. Here we use clinical dose-constraint data to generate dosimetric margins for OA...
Authors: Santosh K. Agarwalla, Nrusingh C. Biswal, Shree C, Harikrishnan Suresh Kumar, Jajati K. Nayak, Prema P., Sarath K S, Tamil Selvan S, Hem D. Shukla
Affiliation: Variable Energy Cyclotron Centre, Department of Physics, Fakir Mohan University, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Sciences, Amrita Vishwa Vidyapeetham
Abstract Preview: Purpose: The rapid oxygen depletion in tissues during irradiation is the most accepted mechanism of the FLASH effect. However, the Normal Tissue Complication Probability (NTCP) and Tumor Control Proba...
Authors: Andrew Huang, Jonathan Huang, Andrew S Kennedy, Ellie Grace Kong, Ajay Zheng
Affiliation: New York Proton Center, Centennial Medical Center, Executive Medical Physics Associates, Sarah Cannon Cancer Institute, Belmont University
Abstract Preview: Purpose:
Lung stereotactic body radiotherapy (SBRT) is the standard of care for early-stage lung cancer. Respiratory phase gating can be applied to mitigate motion-induced effects. The purpose of t...
Authors: Tianyuan Dai, Xiaoying Fan, Shuting Wang, Yong Yin
Affiliation: Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
Abstract Preview: Purpose: Decreased lymphocytes increase the risk of infections and other problems. Radiation exposure can cause the development of severe lymphopenia. In this study, we used a dynamic blood flow model...
Authors: Dennis A. Cheek, Wei Luo, Cameron Thayer-Freeman, Brien Timothy Washington
Affiliation: UT Southwestern Medical Center, University of Kentucky, Department of Radiation Medicine, University of Kentucky
Abstract Preview: Purpose: To investigate the effect of variation in the ฮฑ/ฮฒ of cervical cancer on clinical outcome for cervix cancer patients treated with radiation therapy.
Methods: A distribution of experimentall...
Authors: Xiangli Cui, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences
Abstract Preview: Purpose:
Respiratory motion introduces substantial dose uncertainties in lung cancer radiotherapy, particularly affecting dose distribution in Simultaneous Integrated Boost-Stereotactic Body Radiot...
Authors: Daisuke Kawahara, Yoichi Watanabe
Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, University of Minnesota Medical School
Abstract Preview: Purpose: Combination therapies with immunotherapy (IT) and radiotherapy (RT) are widely used, but the optimal IT timing is unclear. This study leverages a computational cellular automaton (CA) model, ...
Authors: Rachel B. Ger, Xun Jia, Youfang Lai, Todd R. McNutt, Xingyi Zhao
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University
Abstract Preview: Purpose: Radiotherapy (RT) plays an essential role for head and neck (HN) cancer treatment but often results in xerostomia due to salivary gland damage. It is important to mechanistically model the ra...
Authors: Martin Frank, Oliver Jรคkel, Niklas Wahl
Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Karlsruhe Institute of Technology (KIT)
Abstract Preview: Purpose: Machine learning (ML) models on normal tissue complication and tumor control probability ((N)TCP) exploiting e.g. dosiomic and radiomic features are playing an increasingly important role in ...
Authors: Nicholas Joseph Casteloes, Brian T Collins, Sean P Collins, Shiva K. Das, Panayiotis Mavroidis, Michael Repka, Simeng Suy
Affiliation: University of South Florida, University of North Carolina
Abstract Preview: Purpose: To correlate four rectal symptoms with the dose to rectum in patients, who received SBRT with Cyberknife for prostate cancer. Also, to fit those dosimetric and outcome data by using a normal ...
Authors: Nicholas Joseph Casteloes, Brian T Collins, Sean P Collins, Shiva K. Das, Panayiotis Mavroidis, Michael Repka, Simeng Suy
Affiliation: University of South Florida, University of North Carolina
Abstract Preview: Purpose: To correlate two urinary symptoms with dose to bladder and urethra in patients who received SBRT with Cyberknife. Also, to use a normal tissue complication (NTCP) model to fit the dosimetric ...
Authors: Gregory A Azzam, Danielle Cerbon, Laura Huang, Panayiotis Mavroidis, Diana Molinares, Stuart E Samuels, Sotirios Stathakis
Affiliation: Mary Bird Perkins Cancer Center, University of Miami Sylvester Comprehensive Cancer Center, Mount Vernan Rehabilitation Medicine Associates, Department of Radiation Oncology, University of Miami, University of North Carolina
Abstract Preview: Purpose: This study aims at performing a normal tissue complication probability (NTCP) modeling by fitting the doses to the skin, sternocleidomastoid (SCM) muscle and subcutaneous tissue (subcut) stru...
Authors: Jeremy T. Booth, Martin Andrew Ebert, Robert Finnegan, Annette Haworth, George Hruby, Burhan Javed, Kazi Ridita Mahtaba, Leyla Moghaddasi, Yutong Zhao
Affiliation: Northern Sydney Cancer Centre, Royal North Shore Hospital, The University of Sydney, The University of Western Australia, Genesis Care, Rockhampton Hospital
Abstract Preview: Purpose:
To evaluate the efficacy of an atlas-based tumor control probability (TCP) model in predicting prostate cancer (PCa) recurrence by retrospectively integrating patient-specific primary radi...
Authors: Ramesh Boggula, Yash Somnay, Hualin Zhang
Affiliation: Radiation Oncology, Keck School of Medicine of USC, Wayne State University
Abstract Preview: Purpose: Spatially fractionated radiation therapy (SFRT) allows delivery of therapeutic doses to bulky tumors otherwise limited by dose-volume effects that threaten organ-at-risk tolerances. For negle...
Authors: Matthew Case, Richard Castillo, Sunil Dutta, Edgar Gelover, Katja M. Langen, Alexander Stanforth, Mingyao Zhu
Affiliation: Emory University
Abstract Preview: Purpose: To evaluate the application of LETd and track-end (TE) objective functions during the optimization of breast proton therapy plans to decrease the risk of lung toxicity and rib fractures.
M...
Authors: Brian M. Anderson, Simon A. Brundage, Xuguang Scott Chen, Shiva K. Das, Felice Dong, Spencer Lynch, Panayiotis Mavroidis, Ryan Morse Morse, Heidi Urquidi
Affiliation: University of North Carolina Chapel Hill, University of North Carolina at Chapel Hill, University of North Carolina
Abstract Preview: Purpose: This study aims at correlating different dosimetric indices of nodal GTV with the regional recurrencies observed after head and neck radiotherapy. Also, to perform a tumor control probability...
Authors: Wen C. Hsi, Tae Kyu Lee, Biniam Yo Tesfamicael
Affiliation: Allina Health, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Oklahoma Proton Center
Abstract Preview: Purpose: When minimal dose-variations induced by inter-fractional anatomical-changes and positioning-deviation were found for having limited impact on clinic-outcomes of oropharyngeal head-and-neck (H...
Authors: Ana Maria Barragan Montero, John A. Lee, Eliot Peeters, Romain Schyns, Edmond S. Sterpin, Sophie Wuyckens
Affiliation: UCLouvain, Universite Catholique de Louvain
Abstract Preview: Purpose:
Although the likelihood of a point being tumorous decreases with distance from the GTV, CTVs are still defined as binary masks. Recently, the concept of clinical target distribution (CTD),...
Authors: John T Barrett, Dan Heo, Chulhaeng Huh, Farshad Mostafaei
Affiliation: Department of Radiation Oncology, Medical College of Georgia, Augusta University, Department of Radiation Oncology, Augusta University
Abstract Preview: Purpose: This study aimed to compare the tumor control probability (TCP) of radiation therapy (RT) and magnetic hyperthermia combined with RT (MHRT) in the human prostate cancer cells based on radiobi...
Authors: Rama Bhawani, Mary Joan, Ajay Katake, Munish Kumar, Chhape Ram, Megha Sharma, Balbir Singh, Vikram Singh
Affiliation: SLBSGMC & HOSPITAL, MOHANDAI OSWAL HOSPITAL, WOCKHARDT HOSPITAL, Christian Medical College and Hospital,, AMERICAN ONCOLOGY INSTITUTE
Abstract Preview: Purpose: This study aims to evaluate the utility of voxel-based radiobiological modelling in assessing IMRT radiotherapy treatment plans concerning radiation-induced acute mucosal toxicity, specifical...