Authors: Daniel A. Alexander, Anish Butala, Anthony Austin Kassaee, Neil Malhotra, Ian Messing, Gabrielle W Peters, Ryan M. Scheuermann
Affiliation: Department of Radiation Oncology and Applied Sciences, University of Pennsylvania
Abstract Preview: Purpose: Stereotactic Body Radiation Therapy (SBRT) for spinal metastases uses CBCT-based localization and highly conformal treatment delivery to increase the biologically equivalent dose to the targe...
Authors: Justus Adamson, Wesley Andrew Cunningham, Caleb Logan Smith
Affiliation: Duke University, Duke University Medical Center
Abstract Preview: Purpose: Radiation induced bowel toxicity is a persistent issue for abdominal Stereotactic Body Radiation Therapy (SBRT). Remote magnetic navigation systems (RMNS) have been developed for use in magne...
Authors: Andrew Huang, Jonathan Huang, Andrew S Kennedy, Ellie Grace Kong, Ajay Zheng
Affiliation: New York Proton Center, Centennial Medical Center, Executive Medical Physics Associates, Sarah Cannon Cancer Institute, Belmont University
Abstract Preview: Purpose:
Lung stereotactic body radiotherapy (SBRT) is the standard of care for early-stage lung cancer. Respiratory phase gating can be applied to mitigate motion-induced effects. The purpose of t...
Authors: Rodrigo Delgadillo, Nesrin Dogan, Benjamin J. Rich, Stuart E Samuels, Levent Sensoy
Affiliation: University of Miami Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose: Daily Cone beam CT (CBCT) images may be useful in detecting early morphological changes during head and neck cancer radiotherapy. The aim of this study was to evaluate the performance of CBCT...
Authors: Baher Elgohari, M. Saiful Huq, Ronald John Lalonde, Fang Li, Noor Mail, Jeonghoon Park, Tyler Wilhite
Affiliation: UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, UPMC Hillman Cancer Center, UPMC, Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose:
To compare toxicity between consecutive-daily (QD) with every-other-day (QoD) delivery of lung stereotactic-body-radiation (SBRT) for central non-small-cell lung cancer (NSCLC).
Methods...
Authors: Luke Connell, Nolan M. Esplen, Elise Konradsson, Albert C. Koong, Ziyi Li, Steven Hsesheng Lin, Kevin Liu, Billy W Loo, Devarati Mitra, Radhe Mohan, Emil Schueler, Takeshi Takaoka, Uwe Titt, Xiaochun Wang, Ming Yang
Affiliation: The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: This study aimed to assess radiation-induced gastrointestinal (GI) toxicity in mice subjected to abdominal irradiation using protons at ultra-high-dose-rate (UHDR) and conventional dose-rates...
Authors: Adebayo Abe, Samuel Olaolu Adeneye, Bidemi I. Akinlade, Inioluwa Damilola Ariyo, Sylvester Entonu, Muhammad Habeebu, Adedayo O. Joseph, Oluwaseyi Oderinde, Oluwadara Ojediran, Margaret Dideolu Taiwo
Affiliation: University of Ibadan, University of Lagos, Missouri University of Science and Technology, Purdue University, NSIA-LUTH Cancer Center, University of Lagos, NSIA-LUTH Cancer Centre
Abstract Preview: Purpose:
Spatially Fractionated Radiation Therapy (SFRT) is an advanced radiotherapy technique designed to deliver highly heterogeneous radiation doses, aiming to optimize tumor control while minim...
Authors: Serageldin Attia, Zayne Belal, Cem Dede, Clifton David Fuller, Andrew Hope, Laia Humbert Vidan, Kate Hutcheson, Zaphanlene Kaffey, Stephen Y. Lai, Abdallah Mohamed, Amy Moreno, Jillian Rigert, Erin Watson
Affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Princess Margaret Cancer Centre, University Health Network, 610 University Ave., The University of Texas MD Anderson Cancer Center, UT MD Anderson, Princess Margaret Cancer Centre, UT MD Anderson Cancer Center, Hospital of the University of Pennsylvania, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Head and Neck Surgery, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology
Abstract Preview: Purpose: Osteoradionecrosis (ORN) of the jaw is a debilitating radiation-induced toxicity lacking standardized classification criteria or treatment guidelines. Early identification of tissue injury co...
Authors: David Alcorta, Lindsay Bolino, Olivia Canter, Seifallah Emam, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, David Loiselle, Mark Oldham, Victoria J. P. Radosova
Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke Univerity, Department of Radiation Oncology, Duke University Medical Center
Abstract Preview: Purpose: To simulate how Cherenkov light (CL) produced during radiation therapy can activate targeted photodynamic molecules. To experimentally determine dose and concentration thresholds for biologic...
Authors: Christopher Bartee, Justin Riley DeFrancisco, Marcos Feijoo, Siyong Kim, Tianjun Ma
Affiliation: Blue Physics LLC, Virginia Commonwealth University
Abstract Preview: Purpose: Irradiation with FLASH has been shown to decrease normal tissue toxicity while maintaining similar tumor control. To advance FLASH into the clinic, more preclinical investigations are first n...
Authors: Shahabeddin mostafanazhad Aslmarand, Lili Chen, Dusica Cvetkovic, Troy A. Dos Santos, Chang Ming Charlie Ma, Dae-Myoung Yang
Affiliation: Fox Chase Cancer Center
Abstract Preview: Purpose:
Pulsed low-dose-rate radiotherapy (PLDR) has been proposed to reduce normal tissue toxicity while maintaining tumor control comparable to conventional radiotherapy (CRT). This study assess...
Authors: Jack Biondo, Audrey Magness, Anthony E. Mascia, Zhiyan Xiao, Yongbin Zhang
Affiliation: Cincinnati Children's Proton Therapy Center
Abstract Preview: Purpose: Proton FLASH-RT has shown promise reducing normal tissue toxicity while maintaining tumor control. However, in vivo experiments critically depend on achieving ultra-high dose rate (UHDR) and ...
Authors: Niels Bassler, Jonathan Bortfeldt, Davide Boscaini, Francesco Evangelista, Guyue Hu, Ze Huang, Margarita Kozak, Julie Lascaud, Giulio Lovatti, Eero Lönnqvist, Jasper Nijkamp, Munetaka Nitta, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Babak Sharifi, Brita Singers Sørensen, Peter Thirolf
Affiliation: Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital
Abstract Preview: Purpose: To perform the first in vivo application of a novel small animal radiation research platform combining on-board image-guidance with multi-field intensity modulated spot scanning delivery [1] ...
Authors: Xiangli Cui, Lingling Liu
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences
Abstract Preview: Purpose:
Respiratory motion introduces substantial dose uncertainties in lung cancer radiotherapy, particularly affecting dose distribution in Simultaneous Integrated Boost-Stereotactic Body Radiot...
Authors: Eyub Y. Akdemir, Gregory A Azzam, Rupesh Kotecha, Gregory J. Kubicek, Natalia Lutsik, Eric Mellon, Siamak P. Nejad-Davarani, Parag Parikh, Karen C. Snyder
Affiliation: Miami Cancer Institute, Baptist Health South Florida, Department of Radiation Oncology, University of Miami, Henry Ford Health
Abstract Preview: Purpose: Resection cavity volumes shrink gradually over time after surgical resection of brain metastases. Fractionated stereotactic radiosurgery (fSRS) is often delivered to the cavity to prevent rec...
Authors: Lili Chen, Dusica Cvetkovic, Chang Ming Charlie Ma, Dae-Myoung Yang
Affiliation: Fox Chase Cancer Center
Abstract Preview: Purpose: 5-aminolevulinic acid (5-ALA)-mediated radiodynamic therapy (RDT) has been shown to be an effective treatment option using high-energy photon beams. RDT utilizes tumoricidal capabilities caus...
Authors: Smith Apisarnthanarax, Clemens Grassberger, John Kang, Yejin Kim, Justin Leu, Dominic A. Maes, Matthew J. Nyflot, Ramesh Rengan, Annemarie Shepherd, Jing Zeng
Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Washington, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, University of Washington and Fred Hutchinson Cancer Center
Abstract Preview: Purpose: Reirradiation (ReRT) is a rapidly growing clinical challenge driven by better systemic therapy and longer survival, though clear guidelines for ReRT are lacking. Fitting traditional normal ti...
Authors: Rachel B. Ger, Xun Jia, Youfang Lai, Todd R. McNutt, Xingyi Zhao
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University
Abstract Preview: Purpose: Radiotherapy (RT) plays an essential role for head and neck (HN) cancer treatment but often results in xerostomia due to salivary gland damage. It is important to mechanistically model the ra...
Authors: John P. Aris, Wesley E. Bolch, Chansoo Choi, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Abdul-Vehab Dozic, Amy M. Geyer, Harald Paganetti, Shreya P. Pathak, Julia D. Withrow
Affiliation: St. Luke's Health System, Massachusetts General Hospital, University of Florida
Abstract Preview: Purpose: The goal of this study was to enhance the accuracy of renal dosimetry in radiopharmaceutical therapy (RPT) by developing a more detailed and precise kidney model. In RPT, accurate dose estima...
Authors: Liang Cui, Xingyu Lu, Hang Shang, LingHong Zhou
Affiliation: Southern Medical University
Abstract Preview: Purpose: This study examines how varying dose rates of radiotherapy impact normal tissues outside the target area and analyzes the protective effects and regulatory mechanisms of ultra-high dose rate ...
Authors: James Chun Lam Chow, Harry E Ruda
Affiliation: University of Toronto, Princess Margaret Cancer Centre
Abstract Preview: Purpose: FLASH radiotherapy (FLASH-RT) with dose rate greater than 40 Gy/s, has demonstrated potential in reducing normal tissue toxicity while maintaining tumor control. However, accurate and reliabl...
Authors: Laurence Edward Court, Alexandra Olivia Leone, Zhongxing Liao, Saurabh Shashikumar Nair, Joshua S. Niedzielski, Ramon Maurilio Salazar, Ting Xu
Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Radiation Pneumonitis (RP) predictive models often rely on clinical and DVH parameters, but multiomic features from CT imaging and 3D dose distributions from various regions could provide add...
Authors: Kristina Bjegovic, Luke Connell, Emil Schueler, Leshan Sun, Lucy Whitmore, Liangzhong Xiang
Affiliation: University of California, Irvine, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: The use of FLASH-RT in the clinic would greatly reduce off-target radiation toxicity in normal tissues. However, due to the hypo-fractionated delivery of prescribed doses at FLASH dose rates,...
Authors: Ramesh Boggula, Yash Somnay, Hualin Zhang
Affiliation: Radiation Oncology, Keck School of Medicine of USC, Wayne State University
Abstract Preview: Purpose: Spatially fractionated radiation therapy (SFRT) allows delivery of therapeutic doses to bulky tumors otherwise limited by dose-volume effects that threaten organ-at-risk tolerances. For negle...
Authors: Tommaso Frigerio, Joshua Genender, John M. Hoffman, Catherine (Caffi) Meyer
Affiliation: UCLA, David Geffen School of Medicine at UCLA
Abstract Preview: Purpose: Accurate bone marrow segmentation is required for bone marrow dosimetry to monitor for dangers in PSMA-Lu177 radioligand therapy. We introduce a hybrid (AI/semantic knowledge) segmentation pi...
Authors: Kim Creach, Kim Howard, Julius G. Ojwang, Richard A. Shaw, Neelu Soni
Affiliation: Mercy Hospital Springfield
Abstract Preview: Purpose: To present a standardized MRI-CT hybrid workflow for High-Dose-Rate (HDR) Image-Guided Adaptive Brachytherapy (IGBT) in cervical cancer, aligned with AAPM TG-303, as a model to assist with im...
Authors: David L. Barbee, Jose R. Teruel Antolin, Jinyu Xue
Affiliation: NYU Langone Health
Abstract Preview: Purpose: This work introduces a method of regional dose evaluation of normal brain tissue using local target-specific evaluation and compares to global dose evaluation for linac-based single-isocenter...
Authors: Rama Bhawani, Mary Joan, Ajay Katake, Munish Kumar, Chhape Ram, Megha Sharma, Balbir Singh, Vikram Singh
Affiliation: SLBSGMC & HOSPITAL, MOHANDAI OSWAL HOSPITAL, WOCKHARDT HOSPITAL, Christian Medical College and Hospital,, AMERICAN ONCOLOGY INSTITUTE
Abstract Preview: Purpose: This study aims to evaluate the utility of voxel-based radiobiological modelling in assessing IMRT radiotherapy treatment plans concerning radiation-induced acute mucosal toxicity, specifical...
Authors: Kristy K. Brock, Austin Castelo, Yulun He, Zhongxing Liao, Rebecca Lim, Radhe Mohan, Caleb O'Connor, Tien T Tang, Uwe Titt
Affiliation: University of Washington, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Conformal dose distributions in proton radiotherapy promise to reduce normal tissue toxicity such as radiation-induced pneumonitis, but this has not been fully realized in clinical trials. To...