Authors: Anthony Hong Cheol Lim, Alexander R ODell, Alexander Stanforth, Chris C. Wang
Affiliation: Georgia Institute of Technology, Emory University
Abstract Preview: Purpose: The purpose of this work is to investigate the variation of proton RBE, with respect to depth, in the context of clinical SOBP. Employing a novel approach, this study conducts a Monte Carlo s...
Authors: Alejandro Bertolet, Isaac Meyer, Harald Paganetti, Jan PO Schuemann, Wook-Geun Shin
Affiliation: Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: To develop a methodology for Monte Carlo modeling of cell-specific DNA geometries based on Hi-C data using TOPAS-nBio, and to evaluate early DNA damage distributions.
Methods: Hi-C data of...
Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal, Chris C. Wang
Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology
Abstract Preview: Purpose: Radiobiological simulation via TOPAS-nBio requires significant computational resources and time to provide meaningful results. This study aims to decrease simulation time and computational re...
Authors: Ramin Abolfath, Alejandro Bertolet, Kofi M. Deh, Rao Khan, Vanessa Sanders, Daniel Suarez-Garcia
Affiliation: Massachusetts General Hospital and Harvard Medical School, University of Sevilla, Brookhaven National Laboratory, Howard University
Abstract Preview: Purpose: To compare the efficacy of 225Ac to 90Y for local cancer therapy by quantifying DNA damage using Monte Carlo simulations.
Methods: The TOPAS n-Bio toolkit was used to simulate the irradiat...
Authors: Alejandro Bertolet, Jose Antonio Lopez-Valverde, Victor V. Onecha, Daniel Puerta
Affiliation: Dana Farber Cancer Institute/Brigham and Women's Hospital, Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: Besides its superior dose conformity, proton therapy induces greater damage to tissue than conventional radiotherapies. This increased damage is usually quantified through the concept of rela...
Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal
Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology
Abstract Preview: Purpose: The fundamental concept of radiopharmaceutical therapy involves binding radioisotopes to molecules with a known biokinetic distribution, which ensures that the targeted organs receive higher ...
Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Kathryn D Held, Nicolas Henthorn, Jay LaVerne, Thongchai Masilela, Stephen J. McMahon, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin, Michael Taylor, John Warmenhoven
Affiliation: Massachusetts General Hospital, Queen's University Belfast, Massachusetts General Hospital and Harvard Medical School, University of California San Francisco, University of Manchester, Notre Dame University
Abstract Preview: Purpose: TOPAS-nBio brings a cutting-edge Monte Carlo (MC) simulation framework to the research community to test hypotheses of radiation effects at the nanometer/cell scale. Here, we present the deve...