Search Submissions 🔎

Results for "two different": 153 found

3D Bioprinted Brain Cancer Constructs for Experimental Synchrotron Radiotherapy

Authors: John Paul Ortiz Bustillo, Elette Engels, Elrick T. Inocencio, Michael Lerch, Julia Rebecca D Posadas, Anatoly Rosenfeld, Kiarn Roughley, Moeava Tehei, Gordon Wallace, Danielle Warren, Vincent de Rover

Affiliation: Centre for Medical Radiation Physics, University of Wollongong Australia, Department of Radiology, University of the Philippines- Philippine General Hospital, Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong Australia, Centre for Medical Radiation Physics, University of Wollongong, Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, University of the Philippines Manila; Centre for Medical Radiation Physics, University of Wollongong Australia

Abstract Preview: Purpose: To compare the biological response through cell viability assay and fluorescence imaging of 3D bioprinted brain cancer (glioma) constructs relative to 2D monolayer and 3D spheroid culture for...

4D CBCT Reconstruction Using Denoising Diffusion Implicit Models

Authors: Weixing Cai, Laura I. Cervino, Yabo Fu, Bohong Huang, Licheng Kuo, Tianfang Li, Xiang Li, Jean M. Moran, Huiqiao Xie, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Four-dimensional cone-beam computed tomography (4D-CBCT) is critical in image-guided radiotherapy (IGRT) for visualizing tumor motion. However, sparse projection sampling often introduces sev...

A Clinical Evaluation of Two Commercially Available Deep-Learning Algorithms for Automated Organs at Risk Contouring

Authors: Steven DiBiase, Gurtej S. Gill, Haohua Billy Huang, Nicholas J. Lavini, Luxshan Shanmugarajah, Salar Souri, Samantha Wong

Affiliation: Stony Brook University, Northwell Health, Cornell University, NewYork-Presbyterian, New York-Presbyterian

Abstract Preview: Purpose: Clinical applications of deep learning-based algorithms have come to the radiation oncology field as organ at risk (OAR) auto contouring programs. We evaluated two of these algorithms’ (Radfo...

A Comparative Evaluation of CT Global Noise Calculation Methods for Upcoming CMS Image Quality Measure

Authors: Gary Y. Ge, Charles Mike Weaver, Jie Zhang

Affiliation: University of Kentucky

Abstract Preview: Purpose: The recently introduced CMS regulation on CT dose and image quality mandates the use of global noise as the metric for image quality assessment. The regulation cites two methods for calculati...

A Comparison of the Impact to Mean Doses to Organs at Risk of Small Versus Large Spot Sizes in Pelvic Proton Therapy

Authors: Jamie s Baker, Sam Beddar, Mahsa Dehghanpour, Ariel MT Hoang, Emma Holliday, Rachael M. Martin Paulpeter, Joshua S. Niedzielski, Luis Augusto Perles, Josie S Ruzek, Gabriel O. Sawakuchi

Affiliation: MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, niversity of Texas MD Anderson Cancer Center School of Health Professions, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, University of Texas MD Anderson Cancer Center School of Health Professions

Abstract Preview: Purpose: This study aims to evaluate the dosimetric impact on organs at risk (OAR) of small versus large spot sizes when treating pelvic cancer patients with pencil beam scanning (PBS) proton therapy....

A Customizable Phantom Insert Design for Testing Deformable Image Registration with Simulated Respiratory Motion

Authors: Mubasheer Chombakkadath, Tara E. Tyson, Iris Z. Wang

Affiliation: Roswell Park Comprehensive Cancer Center, University at Buffalo (SUNY)

Abstract Preview: Purpose: Deformable image registration (DIR) is critical in adaptive radiation therapy (ART). Existing DIR phantoms either simulate tumor shape or volume changes but lack comprehensive motion simulati...

A Deformable Registration-Based Pipeline for the Characterisation of Respiratory Motion from 2D Lung Cine MRI

Authors: Michael W. Kissick, Chung Tin Lo, Jamie R McClelland, Niek Schreuder, Tracy Underwood

Affiliation: Hawkes Institute, University College London, Leo Cancer Care

Abstract Preview: Purpose: The emerging field of upright radiotherapy raises the question of how respiratory motion differs between upright and supine treatment postures. Therefore, we have developed a versatile pipeli...

A Dosimetric Study of Small-Field Apertured Spot-Scanning Proton Stereotactic Radiosurgery for Pediatric Brain Tumors

Authors: Chin-Cheng Chen, Chia-Ho Hua, Christopher J. Kutyreff, Thomas E. Merchant

Affiliation: St. Jude Children's Research Hospital

Abstract Preview: Purpose: A dosimetric study was conducted to determine the optimal field parameters for a commercially available small-field applicator (SFA) used in spot-scanning proton stereotactic radiosurgery, pa...

A Framework for the Standardization of Radiomics Classes in the Presence of Blur and Noise

Authors: Huay Din, Grace Jianan Gang, Grace Hyun Kim, Michael F. McNitt-Gray, Joseph W. Stayman, Yijie Yuan

Affiliation: Johns Hopkins University, John Hopkins University, University of Pennsylvania, David Geffen School of Medicine at UCLA

Abstract Preview: Purpose:
Radiomics rely on quantitative features to discern underlying biological signatures. However, feature dependence on the imaging systems themselves hampers the creation of reproducible and ...

A Hybrid Population-Based and Patient-Specific Framework for 2D–3D Deformable Registration-Driven Limited-Angle Cone-Beam CT Estimation

Authors: Xiaoxue Qian, Hua-Chieh Shao, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Limited-angle CBCT (LA-CBCT) reduces imaging time and dose but suffers from under-sampling artifacts. 2D–3D deformable registration addresses this problem by estimating LA-CBCTs from defor...

A Method to Check the Consistency and Reproducibility of VMAT Delivery

Authors: Chloe Doen Kim, Patricia E. Lindsay, Bern Norrlinger, Jan P. Seuntjens

Affiliation: Princess Margaret Cancer Centre & University of Toronto, Queen's University, Princess Margaret Cancer Centre

Abstract Preview: Purpose: To propose a method to check the consistency of VMAT delivery on linear accelerator (LINAC) with a commercial three-dimensional array device. The method is insensitive to the correction facto...

A Multi-Criteria Optimization Method Based on Reinforcement Learning and Adaptive Boosting in Radiation Therapy

Authors: Liqin HU, Tao He, Jing JIA, Pengcheng LONG, Wei Meng, Yang Yuan

Affiliation: SuperAccuracy Science & Technology Co. Ltd.

Abstract Preview: Purpose: A multi-criteria optimization method based on reinforcement learning and adaptive boosting(RLAB MCO) has been developed to enhance radiotherapy plan quality by offering reasonable and effecti...

A New Algorithm for Charged Particle Therapy Beam Energy Measurement By Time-of-Flight

Authors: Sung Woon Choi, Dong Wook Kim, Jin Sung Kim, Na Hye Kwon, Paulo Jorge Ribeiro Da Fonte

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Coimbra Institute of Engineering, Polytechnic University of Coimbra

Abstract Preview: Purpose: In hadrontherapy, such as proton and carbon ion therapy, it is desirable, for quality assurance reasons, to have an online beam energy measurement independent from the machine parameters. Sin...

A Novel Method for Virtual Extension of Image-Derived Vasculature Segmentations

Authors: Raneem Atta, Alejandro Bertolet, Mislav Bobić, Wesley E. Bolch, Robert Joseph Dawson, Carlos Huesa-Berral, Harald Paganetti, Eric Wehrenberg-Klee

Affiliation: Massachusetts General Hospital, University of Florida, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: Representations of intra-organ vasculature have a variety of uses in the field of computational dosimetry but generally rely on models derived from population-averaged reference individuals. ...

A Novel Proton Lattice Modality Using Minibeams

Authors: Hao Gao, Yuting Lin, Nimita Shinde, Weijie Zhang

Affiliation: Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: LATTICE, a form of spatially fractionated radiation therapy (SFRT), delivers high-dose peaks and low-dose valleys to the target volume and has been clinically used for large target volumes. H...

A Python Package for GPU-Accelerated Photon Dose Calculation for Advanced and Generalizable Auto-Planning Approaches: Validation for Multiple Linear Accelerator Vendors and Institutions

Authors: Jaryd Ricardo Christie, Anthony J. Doemer, William T. Hrinivich, Junghoon Lee, Calin Reamy, Kundan S Thind

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University, Henry Ford Health

Abstract Preview: Purpose: To develop and validate an open-source Python package for fast, widely compatible, and user-friendly photon dose calculation algorithm through comparisons with clinical treatment planning sys...

A Quantitative Analysis of Hypersight CBCT Image Quality Using a Phantom-Based Approach Under Different Scatter Conditions

Authors: Denisa R. Goia, M. Saiful Huq, Ronald John Lalonde, Fang Li, Noor Mail, Joseph Shields, Christopher Tyerech

Affiliation: UPMC Hillman Cancer Center, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, University of Pennsylvania, UPMC

Abstract Preview: Purpose: HyperSight is a new platform for image-guided radiation therapy, offering advanced reconstruction algorithms, a large field-of-view, and rapid acquisition times. To validate the performance o...

A Quantitative Analysis of Interplay Effects in IMPT for Lung Cancer SBRT: Comparing Two Machine Delivery Sequence Models

Authors: Xiaoda Cong, Xuanfeng Ding, Gang Liu, Peilin Liu, Lewei Zhao

Affiliation: Department of Radiation Oncology, Stanford University, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Corewellhealth William Beaumont University Hospital

Abstract Preview: Purpose: This study quantitatively evaluates the interplay effect in intensity-modulated proton therapy (IMPT) for lung cancer stereotactic body radiotherapy (SBRT) using two different machine deliver...

A Simplified, Rigorous Procedure for Ultrasound Quality Assurance

Authors: Paul L. Carson, Sander Dekker, Stephen Z Pinter, Megan K. Russ

Affiliation: Clinical Imaging Physics Group, Department of Radiology, Duke University Health System, University of Michigan, Cablon Medical B.V., Univ of Michigan, Dept. of Radiology

Abstract Preview: Purpose:
To promote a simplified, inexpensive, but rigorous set of ultrasound QA tests and to evaluate their potential using a Randomly-placed very Hypoechoic Sphere Phantom (RHSP) in comparison to...

A Surface-Conforming Flexible Collimator for Improving Electron Radiotherapy

Authors: Neil A. Kirby, Parker New, Niko Papanikolaou, Holly Paschal, Karl H. Rasmussen, Daniel L. Saenz

Affiliation: UT Health San Antonio

Abstract Preview: Purpose: To simplify the traditional method of patient-specific skin collimation and improve the precision of electron radiotherapy treatment with a new surface conforming collimation system.
Metho...

A Topological Technique to Unify Image Texture and Morphology to Enhance Radiomic Feature Representations

Authors: David Brizel, Kyle J. Lafata, Jian-Guo Liu, Yvonne M Mowery, Yvonne M Mowery, William Paul Segars, Jack B Stevens

Affiliation: Department of Physics, Duke University, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Duke University, Department of Radiation Oncology, Duke University, University of Pittsburgh

Abstract Preview: Purpose: To develop a technique to quantify tumor topology using a unifying mathematical framework that integrates texture and morphology and to evaluate its feasibility as a prognostic biomarker for ...

A Tumor Tracking Method in Surface-Guided Radiotherapy

Authors: Penghao Gao, Zejun Jiang

Affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Artificial Intelligence Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: Real-time tumor tracking can effectively compensate for the impact of respiratory motion on dose distribution. We propose a patient-specific external-internal correlation model driven by opti...

A Two-Marker Method for Calculating the Radiological Magnification of the Hip in Standing Pelvic Radiography

Authors: Walaa Abdelfadeel, Reagan Thomas Dugan, Tiffany Kinsey, Cameron Kofler, Zheng Feng Lu, Ingrid S. Reiser, Gregory Stacy, Sara Wallace

Affiliation: University of Chicago Medicine, University of Chicago

Abstract Preview: Purpose: To develop an accurate, vendor-neutral method for estimating geometric magnification at the plane of the hip joint on standing anterior-posterior (AP) radiographs for digital templating of to...

AI-Based SBRT Dose Prediction Directly from Diagnostic PET/CT: Applications for Multi-Disciplinary Lung Cancer Care

Authors: Pradeep Bhetwal, Wookjin Choi, Adam Dicker, Rupesh Ghimire, Yingcui Jia, Lauren Nkwonta, Yevgeniy Vinogradskiy, Wentao Wang, Maria Werner-Wasik

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: Multi-disciplinary clinics are becoming standard of care for patients with lung cancer treated with SBRT. To improve clinical decision support in a multi-disciplinary clinic, it would be bene...

Advancing Flash Radiotherapy: Intercomparison of Parameters between Two Institutions to Optimize Clinical Applications.

Authors: Amir Abdollahi, Celine Karle, Michele M. Kim, Constantinos Koumenis, Andrea Mairani, Erato Stylianou Markidou

Affiliation: Heidelberg Ion-Beam Therapy Center - Department of Radiation Oncology, German Cancer Research Centre(DKFZ), University of Pennsylvania, Physics Dep. University of Cyprus

Abstract Preview: Purpose: The aim is to compare FLASH dose-rate RT generated with protons and carbon (HIT) and compare to protons (UPenn) to provide evidence for equipotency of FLASH vs. standard RT to tumor growth co...

An Adaptive Radiotherapy Approach Sparing Preirradiated Critical Structures

Authors: Mohamed Bahaaeldin Mohamed Afifi, Lili Chen, Xiaoming Chen, Ahmed A. Eldib, Chang Ming Charlie Ma, Robert A. Price

Affiliation: Fox Chase Cancer Center, Radiological Sciences and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University.

Abstract Preview: Purpose: Reirradiation of recurrent cancer or a newly developed lesion in a proximal location poses a challenge for radiation treatments. This is occasionally encountered in many modern clinics and ef...

An Analytical Approach to Monitor Unit Calculation in Extended Distance Total Body Irradiation (TBI)

Authors: Cheewai Cheng, Indra J. Das, Jeffrey Yui Hei Wong, Poonam Yadav

Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine

Abstract Preview: Purpose: Radiation treatment machine replacement brings chaos and urgency of timely completion of machine commissioning for every procedure used including TBI that are time consuming. Based on past ex...

Analysis of Inter-Organ Noise Variability for Clinical CT Images across 3133 Image Series

Authors: Lavsen Dahal, Francesco Ria, Ehsan Samei, Justin B. Solomon, Liesbeth Vancoillie, Yakun Zhang

Affiliation: Duke University, Carilion Clinic, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System

Abstract Preview: Purpose: Clinical diagnostic task-based optimization of CT procedures require precise and organ-specific assessments. This study investigates inter-organ noise variability to highlight the limitations...

Analyzer-Less X-Ray Interferometry with Super-Resolution Methods

Authors: Joyoni Dey, Hunter Cole Meyer, Murtuza Taqi

Affiliation: Louisiana State University

Abstract Preview: Purpose: We propose using super-resolution methods for X-ray grating interferometry without an analyzer with detectors that fail to meet the Nyquist sampling rate needed for traditional image recovery...

Assessing Low Iodine Concentrations in Liver Lesions with Dual Energy CT: Impact of Beam Choices

Authors: Xinhua Li, Vu Nguyen, Yifang (Jimmy) Zhou

Affiliation: Cedars-Sinai Medical Center

Abstract Preview: Purpose: Assessing iodine concentration in liver lesions is essential for evaluating contrast enhancement in multi-phase liver CT and for accurate disease diagnosis. This study aims to evaluate the as...

Assessing Mlc Errors and Their Dosimetric Impact Delivered on Elekta Linear Accelerator from Two TPS Systems

Authors: Richard Lesieur, Olivia Magneson, David E. Solis, Sotirios Stathakis

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: This study evaluates the deliverability and precision of multileaf collimator (MLC) positioning in treatment plans generated by two different Treatment Planning Systems (TPS), Monaco and Pinn...

Assessing the Risks of Synthetic MRI Data in Deep Learning: A Study on U-Net Segmentation Accuracy

Authors: Chuangxin Chu, Haotian Huang, Tianhao Li, Jingyu Lu, Zhenyu Yang, Fang-Fang Yin, Tianyu Zeng, Chulong Zhang, Yujia Zheng

Affiliation: The Hong Kong Polytechnic University, Nanyang Technological University, Australian National University, Medical Physics Graduate Program, Duke Kunshan University, North China University of Technology, Duke Kunshan University

Abstract Preview: Purpose: Deep learning segmentation models, such as U-Net, rely on high-quality image-segmentation pairs for accurate predictions. However, the recent increasing use of generative networks for creatin...

Assessment of Deep Learning Models for 3D Dose Prediction in Prostate Cancer SIB-IMRT Using MR-Linac

Authors: Hao-Wen Cheng, Jonathan G. Li, Chihray Liu, Wen-Chih Tseng, Guanghua Yan

Affiliation: University of Florida

Abstract Preview: Purpose: This study develops and evaluates deep learning (DL) models for predicting 3D dose distributions in simultaneous integrated boost (SIB) prostate cancer treatment using the Elekta Unity MR-Lin...

Assessment of the Radiological Features of 3D-Printed Polylactic Acid Composites for Creating Personalized Dosimetric Phantoms

Authors: Ashish Binjola, Raj Kishore Bisht, Natanasabapathi Gopishankar, Pratik Kumar, Daya Nand Kishore Sharma, Sukhvir Kishore Singh, Subramani Vellaiyan

Affiliation: Medical Physics Unit, All India Institute of Medical Sciences, All India Institute of Medical Sciences, Department of Radiological Safety, Institute of Nuclear Medicine and Allied Sciences, Department of Radiation Oncology, All India Institute of Medical Sciences

Abstract Preview: Purpose: Additive manufacturing is increasingly being explored to create dosimetry phantoms. Commercial anthropomorphic phantoms represent an average patient and lack anatomical variations due to obes...

Automated Full-Body Tumor Segmentation from PET/CT Images

Authors: Austin Castelo, Xinru Chen, Caroline Chung, Laurence Edward Court, Jaganathan A Parameshwaran, Zhan Xu, Jinzhong Yang, Yao Zhao

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose:
To develop a deep learning-based segmentation model to automatically delineate tumors from full-body PET/CT images.
Methods:
PET/CT image pairs of 91 patients were collected for this...

Automated Multimodal Image Registration for Prostate Bed Radiation Treatment

Authors: Quan Chen, Xue Feng, Chunhui Han, Gaofeng Huang, Trevor Ketcherside, Yi Lao, Yun Rose Li, An Liu, Bo Liu, Kun Qing, William T. Watkins

Affiliation: Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, Department of Radiation Oncology, City of Hope National Medical Center, Mayo Clinic Arizona, Carina Medical LLC

Abstract Preview: Purpose: New treatment platforms such as Ethos (Varian Medical Systems) allow the introduction of multi-modal imaging into adaptive radiotherapy workflow to facilitate an up-to-date view of patients’ ...

Automatic 4D Lung PET-CT Segmentation Using Hybrid Deep Neural Network

Authors: Hongyi Jiang, Fang-Fang Yin

Affiliation: Duke University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose:
Imaging moving tissues using PET-CT can be difficult. Separating signal into phases during construction reduces signal count and increases influence of noise. Algorithms that use signal fr...

BEST IN PHYSICS IMAGING: Cross-Contrast Diffusion: A Synergistic Approach for Simultaneous Multi-Contrast MRI Super-Resolution

Authors: Yifei Hao, Wenxuan Li, Xiang Li, Tao Peng, Yulu Wu, Fang-Fang Yin, Yue Yuan, Lei Zhang, Yaogong Zhang

Affiliation: Duke University, School of Future Science and Engineering, Soochow University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: Diffusion-based deep-learning frameworks have been recently used in MRI resolution enhancement, or super-resolution. Multi-contrast MRI share common anatomical structures while holding comple...

Characterization and Validation of Cerenkov Radiation Extraction Methods from a Plastic Scintillation Detector in 0.35T MR-Linac Environments

Authors: Mateb Ali Alghamwa, Haya Aljuaid, Siyong Kim, Tianjun Ma, William Song

Affiliation: Virginia Commonwealth University

Abstract Preview: Purpose: The integration of Plastic Scintillation Detectors (PSDs) into 0.35T MR-Linac systems represents a significant advancement in radiotherapy, offering substantial benefits due to their tissue-e...

Characterization of a Prototype Flashdiamond Detector for Conventional and Uhdr Beams

Authors: Dominique Guillet, Arthur Lalonde, Bryan R. Muir, James Renaud, Karim Zerouali

Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal, National Research Council

Abstract Preview: Purpose:
To evaluate the dose rate dependence, beam quality dependence, and short-term stability of a novel flashDiamond (fD) prototype detector for conventional and ultra-high dose rate (UHDR) bea...

Characterizing a VMAT Optimization Algorithm with Integrated Static-Angle Modulated Ports for Esophageal Cancer Treatment

Authors: Lei Dong, Yin Gao, Taoran Li, Michael Salerno, Boon-Keng Kevin Teo, Melissa Vila

Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania

Abstract Preview: Purpose: A novel solution, RapidArc Dynamic-RAD (Varian Medical Systems, Palo Alto, USA) has been implemented to integrate VMAT with modulation of IMRT-like static-angle ports, including use of a dyna...

Characterizing the Stability of Upright CT for Proton Therapy

Authors: Brian Burger, Carri K. Glide-Hurst, John W. Hayes, Carson Hoffman, Minglei Kang, Jessica R. Miller, Jordan M. Slagowski, Yuhao Yan

Affiliation: Department of Human Oncology, University of Wisconsin-Madison, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Leo Cancer Care

Abstract Preview: Purpose: The combination of upright CT and patient positioner for particle therapy present tremendous potential for high precision IGRT and online adaptive radiation therapy (ART), where reliable CT p...

Checking of Sensitivity of Volumetric Modulated Arc Therapy Quality Assurance System with a Cavity Generation Method

Authors: Kaile Li, Esmail Parsai

Affiliation: Alexander T. Augusta Military Medical Center, Alexander T. Augusta Miliary Medical Center

Abstract Preview: Purpose: To evaluate the sensitivity of the portal dosimetry system with the Arc CHECK system at identical Volumetric Modulated Arc Therapy (VMAT) setup
Methods: An Arc CHECK system from Sun Nuclea...

Clinical Validation of Fully Automated Script for Plan Conversion between Linacs with Different Mlc Model

Authors: David L. Barbee, Paulina E. Galavis, Lena Adel Samad, Jose R. Teruel Antolin

Affiliation: NYU, NYU Langone Health

Abstract Preview: Purpose: To validate an automated script that converts treatment plans of varying Varian MLC models

Methods: A C# script was developed using the Eclipse Scripting API to convert treatment plans...

Commissioning Radcalc v7.3 with a Collapsed Cone Calculation Algorithm for 6X FFF and 10X FFF Energies

Authors: Maria Jose Almada, Carlos Bohorquez, Maximiliano Musso, Rosa Petit, Carlos Daniel Venencia, Lucy D. Wolfsberger

Affiliation: LAP, Instituto Zunino - Fundacion Marie Curie

Abstract Preview: Purpose:
PSQA is crucial in maintaining patient safety, typically depending on dosimetric measurements. However, advancements in computational technology have highlighted the growing significance o...

Commissioning and Validation of Monaco Proton Treatment Planning System on a Compact Proton Therapy System

Authors: Shupeng Chen, Xiaoda Cong, Raymond Dalfsen, Rohan Deraniyagala, Xuanfeng Ding, James E. Dolan, Xiaoqiang Li, Jian Liang, Peilin Liu, An Qin, Martin Soukup, Craig Stevens, Xiangkun Xu, Weili Zheng

Affiliation: Corewell Health William Beaumont University Hospital, Corewellhealth William Beaumont University Hospital, William Beaumont University Hospital, Elekta, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Corewellhealth William Beaumont Hospital, Department of Radiation Oncology, Corewell Health William Beaumont University Hospital

Abstract Preview: Purpose: To facilitate clinical use of the proton feature of Monaco treatment planning system(TPS), we commissioned and validated it on a compact proton therapy system.
Methods: Pencil Beam Scannin...

Commissioning of a Near Real-Time In Vivo Film Dosimetry System

Authors: Maria F. Chan, Indra J. Das, Xiuxiu He, Seng Boh Gary Lim, Jeonghoon Park, Yunjie Yang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: There is a need for accurate and flexible in-vivo dosimetry systems, particularly for special procedures. Effective dosimetry is crucial for dose verification and maintaining records. A new r...

Commissioning, Validation and Pilot Study of New Rpld System for Dosimetry Audits in Bulgaria

Authors: Gueorgui Gueorguiev, Katia Sergieva, Filip Simeonov, Tsvetelina Todorova, Bozhidar Vladimirov

Affiliation: National Centre of Radiobiology and Radiation Protection, Queen Giovanna University Hospital

Abstract Preview: Purpose: Dosimetry audit is an essential tool enhancing confidence in the accuracy of treatment delivery and in prevention of radiation treatment incidents. Current work depicts how novel nationwide r...

Compact Representation of External Beam Photon Phase Space Data Via Implicit Neural Representation Learning

Authors: Serdar Charyyev, Cynthia Fu-Yu Chuang, Veng Jean Heng, Lianli Liu, Lei Xing, Yong Yang

Affiliation: Department of Radiation Oncology, Stanford University

Abstract Preview: Purpose: To replace large finite-size photon phase space files with a compact neural network capable of generating an infinite number of particles.
Methods: Three separate models were developed to ...

Comparison Analysis of Three Kind of Solutions for Head and Neck Cancer VMAT Verification

Authors: Wenwen Bai

Affiliation: The Fourth Hospital of Hebei Medical University

Abstract Preview: Purpose: To compare three kind of solutions (EDR2 Film, MatriXX, COMPASS) for VMA quality assurance at head and Neck in Monaco plannig system.
Methods: Monacao 5.1 planning system optimazed 10 case...

Comparison of Computed Tomography Scanner Protocols Using an in-House Automated Method across Machines at a Single Institution

Authors: Matthew R. Hoerner, Maryam Naseri, Mena Shenouda

Affiliation: Yale University School of Medicine, Yale University

Abstract Preview: Purpose: To evaluate acquisition parameters of computed tomography (CT) scanner protocols across different machines to provide patients and clinicians consistent care and image quality, respectively.<...

Comparison of Dose Metrics to Critical Heart Substructures for Different Planning Techniques, and Scan Techniques for Right Sided Breast Irradiation

Authors: Wesley A. Belcher, Aidan Burke, Matthew Green, Taylor Stamey

Affiliation: ECU Health, East Carolina University Brody School of Medicine

Abstract Preview: Purpose: The purpose of this study was to determine the effect of using deep inhalation breath hold (DIBH) vs. free breathing (FB) and intensity-modulated radiation therapy (IMRT) vs. 3D for right-sid...

Comprehensive Analysis of Plan Modulation in SRS/SBRT Plans: A Single Institution Study of 461 Cases

Authors: Yunfeng Cui, Will Giles, Xinyi Li, Ke Lu, Jennifer C. O'Daniel, Anna E. Rodrigues, Chunhao Wang, Lana Wang, Yibo Xie, Sua Yoo, Jingtong Zhao

Affiliation: Duke University, Duke University Medical Center

Abstract Preview: Purpose:
To establish quantitative measurement of plan modulation for SRS/SBRT treated with Volumetric Modulated Arc Therapy (VMAT) on C-arm LINACs.
Methods:
A total of 461 plans were analyze...

Comprehensive Assessment of Intra-Fractional and Inter-Fractional Motion in Intensity-Modulated Proton Therapy for Esophageal Cancer

Authors: Tianyuan Dai, Xiaoying Fan, Shuting Wang, Yong Yin

Affiliation: Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: The purpose of this study was to investigate the interplay effect during intra-fractional motion and the effect of the robust optimization parameters for inter-fractional motion in the intens...

Correction Factors for Estimating Skin Dose from Overresponse of Two Commercial Optically Stimulated Luminescence Dosimeters

Authors: Min Cheol Han, Chae-Seon Hong, Changhwan Kim, Dong Wook Kim, Hojae Kim, Hojin Kim, Jin Sung Kim, HO Lee, Kwangwoo Park, Ye-In Park, Junyoung Son

Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Yongin Severance Hospital, Yonsei University College of Medicine

Abstract Preview: Purpose: Overresponse in surface in-vivo dosimetry using optically stimulated luminescence dosimeter (OSLD) depends on the beam incidence angle. This study aimed to investigate correction factors to d...

Cross-Calibration and Comparison of CT Number to Electron Density Using Two Calibration Phantoms

Authors: Afrouz Ataei, Xinhui Duan, Andrew R. Godley, Mi-Ae Park, Mahbubur Rahman, Liqiang Ren, Chenyang Shen, Gary Xu

Affiliation: Department of Radiology, UT Southwestern Medical Center, UT Southwestern Medical Center, Rush University, Imaging Services, UT Southwestern Medical Center

Abstract Preview: Purpose:
Electron density (ED) phantoms are crucial for calibrating CT number (HU) to relative ED in treatment planning. This study evaluates the differences in HU-to-ED calibrations between two co...

Cross-Calibration of CT Number to Electron and Physical Density: Feasibility of Using Diagnostic Scans for Treatment Planning

Authors: Afrouz Ataei, Andrew R. Godley, Mi-Ae Park, Mahbubur Rahman, Liqiang Ren, Chenyang Shen, Gary Xu

Affiliation: Department of Radiology, UT Southwestern Medical Center, UT Southwestern Medical Center, Rush University, Imaging Services, UT Southwestern Medical Center

Abstract Preview: Purpose: Even though many patients undergo diagnostic CT scans prior to treatment, simulation CT scans are commonly required for treatment planning. This study evaluates whether prior diagnostic CT sc...

Deep Learning Aided Oropharyngeal Cancer Autoplanning

Authors: Mark Bowers, Gabriel Carrizo, Jimmy Caudell, Vladimir Feygelman, Kevin Greco, Christian Hahn, Jihye Koo, Kujtim Latifi, Fredrik Lofman, Jacopo Parvizi, Muqeem Qayyum, Caleb Sawyer

Affiliation: RaySearch Laboratories, Moffitt Cancer Center

Abstract Preview: Purpose: Head and neck (H&N) radiotherapy planning is complex, with multiple competing objectives. We endeavored to improve efficiency of planning by developing a deep learning (DL) model trained to p...

Deeptuning: A Deep Learning Dose Prediction Framework for Interactive Plan Tuning

Authors: Mingli Chen, Huan Amanda Liu, Weiguo Lu, Lin Ma

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Mayo Clinic

Abstract Preview: Purpose: To reduce the back-and-forth in planning process between physicians and dosimetrists resulting from trade-off exploration, we proposed a novel deep learning framework called DeepTuning.
Me...

Detection of the Linac Jaw Face Angle Misalignment: Case Studies

Authors: Peter Balter, Andres V Cibrian, Song Gao

Affiliation: The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: The purpose of this study is to demonstrate a means of detecting misaligned jaw face angles on the Varian TrueBeam based on a beam symmetry metric for electron beam profiles.
Methods: Duri...

Determining Optimal Delivery Pattern for Reference Dosimetry in Pencil Beam Scanning Proton Therapy

Authors: Clifford Ghee Ann Chua, Calvin Wei Yang Koh, Kah Seng Lew, Zubin Master, Sung Yong Park, Hong Qi Tan, Andrew Wibawa

Affiliation: National Cancer Centre Singapore

Abstract Preview: Purpose: To investigate the impact of spot position deviation on reference dosimetry measurements using different delivery patterns and to determine the optimal delivery pattern for reference dosimetr...

Determining the Effect of Motion during Gamma Knife Stereotactic Radiosurgery on Anterior and Posterior Lesions Using an Anthropomorphic Phantom

Authors: Guang-Pei Chen, Nitish Chopra, Juan A. Garcia-Alvarez, Mi Huang, Slade J. Klawikowski, Haidy G. Nasief, George A. Noid, Abdul Parchur, Eric S. Paulson, Christina M. Sarosiek, Christopher Schultz

Affiliation: Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: During routine delivery of mask-based Gamma Knife (GK) SRS, motion is tracked via the position of a reflective sticker placed on the patient’s nose relative to two stationary reflectors on th...

Developing 3D-Printed Synthetic Vertebrae with Realistic Surgical Haptic Feedback and Biomechanical Properties

Authors: Chloe Duncan, Andrew Kanawati, Peter Malek, Tess Reynolds

Affiliation: University of Sydney, Westmead Hospital, Image X Institute, Faculty of Medicine and Health, The University of Sydney

Abstract Preview: Purpose: Pedicle screw fixation, a standard spinal surgery procedure, has high misplacement rates (~40%) which decrease with surgeon experience. However, opportunities for surgical rehearsal, training...

Developing a Dataset for Investigations into the Impact of CT Acquisition and Reconstruction Conditions on Quantitative Imaging Using Paired Image Quality and Radiomics Phantom Data

Authors: Morgan A. Daly, David J. Goodenough, Andrew M. Hernandez, John M. Hoffman, Joshua Levy, Michael F. McNitt-Gray, Ali Uneri, Bino Varghese

Affiliation: University of California, George Washington University, David Geffen School of Medicine at UCLA, Johns Hopkins Univ, University of Southern California, The Phantom Laboratory

Abstract Preview: Purpose: Quantitative imaging is affected by CT acquisition and reconstruction conditions, limiting robustness in multi-site or -scanner studies. This work aimed to develop a dataset that will enable ...

Development of Cross-Platform Application for Radiation Contamination Assessment

Authors: Wesley E. Bolch, Lotem Buchbinder Shadur, Natalia Estefania Carrasco-Rojas, Chansoo Choi, Robert Joseph Dawson, Shaheen Dewji, John Francis, Emmanual Mate-Kole, Wyatt Smither, Yitian Wang

Affiliation: Georgia Tech, University of Florida, Nuclear and Radiological Engineering and Medical Physics Programs, Georgia Institute of Technology

Abstract Preview: Purpose: Develop a software application capable of assessing the radiation contamination of military service members and members of the general public for fast, on-site radiological triage. The softwa...

Does the Method Matter? How in Hominum, In Vivo, in silico, and in Phantasma Measures Compare and Contrast Is Assessing the Utility of Photon Counting CT?

Authors: Ehsan Abadi, Njood Alsaihati, Steven T. Bache, Mridul Bhattarai, Cindy Marie McCabe, Francesco Ria, Ehsan Samei

Affiliation: Duke University, Center for Virtual Imaging Trials, Duke University, Duke University Health System, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System

Abstract Preview: Purpose: To compare and contrast alternative methods including reader (in hominum), phantom (in phantasma), in vivo, and in silico methods deployed to assess the performance of photon counting (PCCT) ...

Dose Reconstruction from Prompt-Gamma Imaging Towards Real-Time Adaptive Proton Therapy

Authors: Thomas R. Bortfeld, Prof. Elisabetta De Bernardi, Tianxue Du, Beatrice Foglia, Chiara Gianoli, Takamitsu Masuda, Katia Parodi, Marco Pinto, Boon-Keng Kevin Teo, Yunhe Xie

Affiliation: Department Of Radiation Oncology, Massachusetts General Hospital (MGH), School of Medicine and Surgery, University of Milano-Bicocca, Department of Medical Physics, Ludwig-Maximilians-Universität Mßnchen (LMU Munich), Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen, National Institutes for Quantum Science and Technology (QST), University of Pennsylvania, Department of Experimental Physics - Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen

Abstract Preview: Purpose: The full potential offered by protons in clinical practice is limited by range uncertainties. One possibility for monitoring is through secondary prompt gammas (PG). PG emission along the pen...

Dosimetric Accuracy Evaluation of Brainlab Elements 4.0 Treatment Planning System

Authors: Bhuvaneswari Narayanan, Niko Papanikolaou, Daniel L. Saenz

Affiliation: UT Health San Antonio, University of Texas HSC San Antonio

Abstract Preview: Purpose: To evaluate dosimetric accuracy of Brainlab Elements (BLE) 4.0 treatment planning system (TPS) for linac based SRS and Spine SBRT treatment.
Methods: RT Safe cranial and thorax phantoms wi...

Dosimetric Assessment of Simultaneous Multi-Energy and Fluence Optimization for IMRT and VMAT

Authors: Aliasghar Rohani, Rui Zhang

Affiliation: Louisiana State University, Baton Rouge, Louisiana, Department of Radiation Oncology, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: This study aimed to evaluate the impact of simultaneous optimization of multi-photon beam energy and fluence on IMRT and VMAT treatment planning.
Methods: An Elekta linear accelerator (lin...

Dosimetric Parameter Cross-Check Evaluations for Dedicated Biologically-Guided Radiotherapy Linac Using Two Water Phantom Systems

Authors: Nguyen Phuong Dang, Mason Hazlett, Lijun Ma, Yutaka Natsuaki, William T. Watkins, Zhengzheng Xu, Timothy Pok Chi Yeung

Affiliation: Reflexion Medical Inc,, Radiation Oncology, Keck School of Medicine of USC, RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center

Abstract Preview: Purpose: This is the first study reporting the beam dosimetric parameter cross-checks of Reflexion linac using different water phantom systems and detectors. The difference in measurements using diffe...

Dosimetry Calibration for Low-Energy Protons (2-4 MeV) Using Gafchromic Film Dosimeters

Authors: Michael Dingfelder, Homeira Faridnejad

Affiliation: East Carolina University, Department of Physics, East Carolina University

Abstract Preview: Purpose: To use Gafchromic film for measurement of the dose delivered by low-energy (2-4 MeV) protons to living cells.
Methods: Five different types of Gafchromic films were tested for dosimetry un...

Dosimetry Comparison of Surface-Guided and Orthogonal X-Ray Film-Based Setups for Proton Pencil-Beam Scanning in Breast Cancer Treatment

Authors: Darren Kaplan, Chenguang Liu, Mark Pankuch

Affiliation: Northwestern Medicine Proton Center

Abstract Preview: Purpose: This study evaluates the hypothesis that surface-guided radiation therapy for the breast or chest wall using proton PBS provides comparable target coverage and OARs sparing to x-ray-based IGR...

Dosimetry Impact of Beam Flatness on a Clinical Synchrocyclotron Proton System

Authors: Winter Green, Yao Hao, Nels C. Knutson, Matthew C. Schmidt, Xiandong Zhao

Affiliation: Washington University School of Medicine in St. Louis, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, WashU Medicine

Abstract Preview: Purpose: Beam profile flatness is crucial for both photon and proton radiotherapy systems. This work investigated the dosimetry impact of beam flatness on a clinical synchrocyclotron proton system.

EBT4 Film Dosimetry and the Significance of the Âź Fwhm Rule for Gamma Knife Output Factors

Authors: Jingying Lin, Stevan Pecic, Strahinja Stojadinovic

Affiliation: University of Belgrade, The University of Texas Southwestern Medical Center

Abstract Preview: Purpose: This study aims to determine the magnitude of polarization-induced dosimetric error for EBT4 films at different scanning orientations, and to provide guidance on selecting appropriate regions...

Enhance Four-Dimension Cone-Beam Computed Tomography (4D-CBCT) from Sparse Views Using a Novel Deep Learning Model

Authors: Lei Ren, Jie Zhang

Affiliation: University of Maryland School of Medicine

Abstract Preview: Purpose: 4D-CBCT is valuable for imaging anatomy affected by respiratory motions to guide radiotherapy delivery. However, 4D-CBCT often has undersampled projections acquired in each respiratory phase ...

Enhancing Lung SBRT Planning Efficiency: A Template-Based Approach Using Chest Wall Overlapping Cases

Authors: Felicia Chu, Qiongge Li, Jian Liu

Affiliation: Inova Hospital, Brown University Rhode Island Hospital, Hofstra University Medical Physics Program

Abstract Preview: Purpose:
This study aims to enhance the efficiency of stereotactic body radiation therapy (SBRT) planning for lung cancer by developing and evaluating optimization templates derived from historical...

Evaluating the Aktina Isopoint System for Quality Assurance in Linear Accelerators

Authors: Blessing Chinelo Akah, Daniel W. Neck, David J. Perrin, Sotirios Stathakis

Affiliation: Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: To assess the reliability of the Aktina Isopoint software in evaluating different components of the linear accelerator for optimized quality assurance and linac performance
Methods: The Ak...

Evaluating the Impact of Different Deface Algorithms on the Deep Learning Segmentation Software Performance

Authors: Ali Ammar, Quan Chen, Yi Rong, Libing Zhu

Affiliation: Mayo Clinic Arizona

Abstract Preview: Purpose: To investigate how defacing algorithms, essential for patient privacy in data sharing, impact AI-based segmentation performance in CT imaging for radiation therapy. This study evaluates wheth...

Evaluating the Interchangeability of Two Similar but Not Beam-Matched Varian Truebeam Linear Accelerators in the Delivery of Patient-Specific Quality Assurance

Authors: Elizabeth M. Alves, Alistair K. Templeton, Julius V. Turian

Affiliation: Rush University Medical Center

Abstract Preview: Purpose: To test the performance of two similar, but not beam-matched, linacs in interchangeably delivering IMRT and VMAT patient-specific quality assurance (PSQA) tests.
Methods: Two TrueBeam lina...

Evaluation of Dose-Rate Metrics in Intensity Modulated Proton Therapy for Prostate Cancer Treatments

Authors: Stella Flampouri, Edgar Gelover, William Andrew LePain, Roelf L. Slopsema, Alexander Stanforth, Mingyao Zhu

Affiliation: Emory Healthcare, Emory University

Abstract Preview: Purpose: Little consideration was given to the change in dose rate (DR) observed when moving to pencil beam scanning (PBS). This study reports on DR in clinical prostate PBS plans. While dose distribu...

Evaluation of MR Proton Density Fat Fraction (PDFF) for Bone Marrow Protection in RT

Authors: Li Tong, Chuyan Wang, Zhengkui Wang, Yingli Yang, Jie Zhang

Affiliation: Shanghai United imaging Healthcare Advanced Technology Research Institute, Shanghai United Imaging Healthcare Co., LTD, Department of Radiology, Ruijin Hospital, Institute for Medical Imaging Technology, Ruijin Hospital

Abstract Preview: Purpose:
Pelvic radiotherapy (RT)-induced bone marrow (BM) damage affects patient prognosis by causing hematologic toxicity. However, consensus on BM-sparing (BMS) RT is still lacking, owing to the...

Evaluation of a Commercially Available Solution for Dose Verification Using Daily AI Generated Pseudo-CT from CBCT.

Authors: Chloe DiTusa, Panayiotis Mavroidis, Christopher W. Schneider, Sotirios Stathakis

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center, University of North Carolina

Abstract Preview: Purpose: To evaluate and compare dose calculation differences between Monaco and AdaptBox by TheraPanacea on AI-generated pseudo-CTs (pCTs) from a CBCT.

Methods: Dose calculations in water phan...

Evaluation of a Novel Multimodal Deformable Image Registration Algorithm for Pelvic MRI-CT Fusion in Radiotherapy

Authors: Christian Fiandra, Marco Fusella, Gianfranco Loi, Silvia Pesente, Lorenzo Placidi, Claudio Vecchi, Orlando Zaccaria, Stefania Zara

Affiliation: Abano Terme Hospital, University of Turin, Maggiore della CaritĂ , Tecnologie Avanzate Srl, Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Abstract Preview: Purpose: Deformable-image-registration (DIR) is essential in modern radiotherapy for adaptive RT, re-irradiation, and other clinical applications. Multimodal DIR is especially important in MRI-only wo...

Experience in Commissioning and Quality Assurance of Halcyon Linear Accelerator Ver3.0 at a Community Hospital and an Academic Institution

Authors: Emily Y. Hirata, Xiaoyu Sherry Liu, Evan Porter, Manju Sharma

Affiliation: University of California San Francisco, University of California, San Francisco, University of California

Abstract Preview: Purpose:
The Varian Halcyon Linear Accelerator has become increasingly popular in both community hospitals and academic institutions due to its user-friendly design and operational efficiency. This...

Extremity Imaging with Cone-Beam CT (CBCT) Scanner Dedicated for Hip Imaging – What Are the Effective Doses?

Authors: Jeff Boob, Jaydev K. Dave, Tim Minch, Bhavyata Tanna

Affiliation: Dr. Ronald E. McNair Academic High School, Mayo Clinic, CurveBeam AI

Abstract Preview: Purpose: To compute effective doses associated with imaging of the extremities with a HiRise (CurveBeam AI, Hatfield, PA) cone-beam CBCT scanner specifically designed for weight-bearing imaging of the...

Eye-Tracking Analysis of Radiologist Preferences in PET Imaging: Comparing 5-Ring and 6-Ring Detector Configurations

Authors: Samuel L. Brady, Joseph G. Meier, Elanchezhian Somasundaram, Andrew T Trout

Affiliation: Cincinnati Children's Hospital Medical Ctr, Cincinnati Childrens Hospital Med Ctr

Abstract Preview: Purpose:
To analyze eye-tracker gaze data for insights into radiologists’ areas of focus in an observer study of whole-body PET images.
Methods:
For a comparative study of dose matched PET im...

Failure Mode and Effects Analysis (FMEA) on Use of Surface Guided Imaging

Authors: Victoria Noelle Bry, Tamara Egan, Eric C. Ford, Angelia Landers, Juergen Meyer

Affiliation: Fred Hutch Cancer Center, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, University of Washington

Abstract Preview: Purpose: Surface guided radiation therapy (SGRT) can improve patient safety, however, its complex integration may expose processes to increased risk of error. This work identifies potential failures f...

Feasibility of Developing a Radiomic Fingerprint to Predict Pulmonary Embolism Clot Types to Aid in Determining Intervention for Intermediate-Risk Patients.

Authors: Lindsay Hammons, Lisa Baumann Kreuziger, Haidy G. Nasief, Matthew Scheidt, Farrell Sean, Antonio Sosa Lozano

Affiliation: Division of Hematology and Oncology, University of Washington, Vascular and Interventional Radiology, Medical college of wisconsin, Department of Radiation Oncology, Medical College of Wisconsin

Abstract Preview: Purpose: Venous thromboembolism, which includes pulmonary embolism (PE), is the third leading cause of acute cardiovascular syndrome behind myocardial infarction and stroke. Current research categoriz...

Fine-Tuning AI-Based Generative Models for Small-Sample Glioma MRI Generation.

Authors: Xiangli Cui, Chunyan Fu, Man Hu, Wanli Huo, Jingyu Liu, Jianguang Zhang, Yingying Zhang, Shanyang Zhao

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University, Departments of Radiation Oncology, Zibo Wanjie Cancer Hospital, Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province, College of Information Engineering, China Jiliang University, Department of Oncology, Xiangya Hospital, Central South University, College of Information Engineering, China Jiliang University, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences

Abstract Preview: Purpose: To quantify the impact of fine-tuning strategies for pre-trained AI image generation models on glioma MRI image quality and observer performance, and to determine the optimal fine-tuning conf...

First in-Vivo Application of a Novel Precision Small Animal Irradiation Platform with Proton IMPT Delivery and Advanced on-Board Image-Guidance

Authors: Niels Bassler, Jonathan Bortfeldt, Davide Boscaini, Francesco Evangelista, Guyue Hu, Ze Huang, Margarita Kozak, Julie Lascaud, Giulio Lovatti, Eero LÜnnqvist, Jasper Nijkamp, Munetaka Nitta, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Babak Sharifi, Brita Singers Sørensen, Peter Thirolf

Affiliation: Department of Medical Physics, Ludwig-Maximilians-Universität Mßnchen (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital

Abstract Preview: Purpose: To perform the first in vivo application of a novel small animal radiation research platform combining on-board image-guidance with multi-field intensity modulated spot scanning delivery [1] ...

Formulation of Equivalent Dose in 2-Gy Fractions (EQD2) Based on the Linear-Quadratic-Linear (LQL) Model from First Principles

Authors: Makunda Aryal, Qiongge Li, Sook Kien Ng, Christopher F. Njeh, Edwin Quashie, Senthamizhchelvan Srinivasan, Yun Wang

Affiliation: Indiana University Medical School, Memorial Health Care System, Indiana University, Inova Hospital, Indiana University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose: Linear-Quadratic-Linear (LQL) model is a modification of the traditional Linear-Quadratic model used in radiobiology to describe cell survival in response to radiation. The LQL model extends ...

From Supine to Upright: A Geometric Shift in Perspective

Authors: Ben Durkee, Renata Farrell, Carri K. Glide-Hurst, Colin Harari, Alex Singleton Kuo, Chase Ruff, Jordan M. Slagowski, Yuhao Yan

Affiliation: University of Wisconsin, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: Advances in upright CT and patient positioning system now enables high quality daily CT imaging and treatment delivery in the upright position, providing benefits including reduced internal m...

Geometric Alignment of MV-CBCT and Dual-Layer Kv-CBCT Projections Using Deep Learning

Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Nicholas Lowther, Daniel Morf, Marios Myronakis

Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Womens Hospital, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory, Dana-Farber Cancer Institute

Abstract Preview: Purpose: Applications of combined kV-MV CBCT include metal artifact correction and material identification. Difficulties arise, however, when the imagers have misaligned geometric perspectives of the ...

Getting in Focus: Review of Current Focal Spot Size Testing Methods with Flat Panel Digital Radiography Detectors

Authors: Matthew R. Hoerner, Maryam Naseri, Mena Shenouda

Affiliation: Yale University School of Medicine, Yale University

Abstract Preview: Purpose:
Historically film has been the gold standard receptor for measurements of x-ray tube focal spot size. Flat Panel Digital Radiography Detectors (FPDRDs) have lower spatial resolution compar...

Impact of Six Degrees of Freedom Intrafraction Motion on Target Coverage for Single-Isocenter Multi-Target Stereotactic Radiosurgery

Authors: Anupama Chundury, Hyejoo Kang, John C. Roeske, Iris A. Rusu

Affiliation: Loyola University Medical Center, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago

Abstract Preview: Purpose: To quantify the dosimetric impact of six degrees of freedom (6DoF) intrafractional errors on gross tumor volume (GTV) and planning target volumes (PTV) for single-isocenter multi-target stere...

Improving 4D-MRI Parameters for Abdominal Tumor Motion Management: A Phantom Study

Authors: Morgan Aire, Krystal M. Kirby, Olivia Magneson, David E. Solis

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: For soft-tissue abdominal tumors, a 4D-MR may provide improved tumor tracking over the clinical standard 4D-CT. This project aims to optimize a clinically available 4D-MR pulse sequence to ac...

Improving Output Stability with Angular Correction Factor on Pencil Beam Scanning Proton System

Authors: Akbar Anvari, Carnell J. Hampton, Melanie R. Piantino, Kai Yang

Affiliation: Levine Cancer Institute, Atrium Health

Abstract Preview: Purpose: To evaluate the effectiveness of angular correction factor for output stability on Mevion S250i Hyper scanning machine, which allows user to apply correction factors for output at selected ga...

Improving the Robustness of AI-Based Detection and Segmentation for Brain Metastasis By Optimizing Loss Function and Multi-Dataset Training

Authors: Omar Awad, Alfredo Enrique Echeverria, Issam M. El Naqa, Daniel Allan Hamstra, Yiding Han, Ryan Lafratta, Abdallah Sherif Radwan Mohamed, Piyush Pathak, Zaid Ali Siddiqui, Baozhou Sun, Vincent Ugarte

Affiliation: H. Lee Moffitt Cancer Center, Harris Health, Baylor College of Medicine

Abstract Preview: Purpose:
Accurate detection and segmentation of brain metastases are critical for diagnosis, treatment planning, and follow-up imaging but are challenging due to labor-intensive manual assessments ...

Inconsistencies in Methods for CMS Size-Adjusted Dose Measure

Authors: Alexander Alsalihi, Gary Y. Ge, Charles Mike Weaver, Jie Zhang

Affiliation: University of Kentucky

Abstract Preview: Purpose: The upcoming CMS regulation, titled “Excessive Radiation Dose or Inadequate Image Quality for Diagnostic Computed Tomography (CT) in Adults”, employs two measures, size-adjusted DLP (SAD) and...

Initial Phantom Studies Towards Implementation of Sequential Dual Energy CBCT on an Adaptive Radiotherapy Linac Platform

Authors: James M. Balter, Alexander Moncion, Ikechi S Ozoemelam

Affiliation: University of Michigan

Abstract Preview: Purpose: Sequential dual-energy cone beam computed tomography (DE-CBCT) integrated with an online adaptive platform could potentially improve soft tissue visualization for more accurate anatomical del...

Innovative Workflow for Enhanced in-Vivo Dosimetry Using Gafchromic Film

Authors: Salim Balik, Nguyen Phuong Dang, Hualin Zhang

Affiliation: Radiation Oncology, Keck School of Medicine of USC

Abstract Preview: Purpose: An accurate and convenient monitoring of radiation dose delivery during treatment is essential for ensuring patient safety and treatment efficacy. This project aims to develop innovative algo...

Integrating Foundation Model with Self-Supervised Learning for Brain Lesion Segmentation with Multimodal and Diverse MRI Datasets

Authors: Zong Fan, Fan Lam, Hua Li, Rita Huan-Ting Peng, Yuan Yang

Affiliation: University of Illinois at Urbana Champaign, University of Illinois at Urbana-Champaign, Washington University School of Medicine, University of Illinois Urbana-Champaign

Abstract Preview: Purpose: Accurate lesion segmentation in MRI is critical for early diagnosis, treatment planning, and monitoring disease progression in various neurological disorders. Cross-site MRI data can alleviat...

Integrating SPECT and Compton Imaging for Multi-Energy Photon Reconstruction

Authors: Qihui Lyu, Javier Caravaca Rodriguez, Youngho Seo, Ke Sheng, Jingjie Yu

Affiliation: University of California San Francisco, University of California, San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose:
Simultaneous broad-energy imaging is critical for many theragnostic applications, but the current Single-Photon Emission Computed Tomography (SPECT) can only image low energy photons with ...

Inter-Patient Adaptive Radiotherapy (IPART): A CT Simulation and Planning Free Approach Enabling Immediate Treatment Access for Patients.

Authors: Bin Cai, Andrew R. Godley, Brian A. Hrycushko, Heejung Kim, Mu-han Lin, David D.M. Parsons, Justin D. Visak, Da Wang, Tingliang Zhuang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: The standard radiation therapy workflow requires CT-simulation and planning, whether for initial treatments or re-planning due to significant anatomical changes. IPART instead uses one patien...

Investigation of Low Iodine Concentration Detectability of Dual-Energy CT Imaging Using a Customized 3D Printed Phantom

Authors: Michalis Aristophanous, Laura I. Cervino, Maria F. Chan, Puneeth Iyengar, Hsiang-Chi Kuo, Nancy Y Lee, Xiang Li, Seng Boh Gary Lim, Usman Mahmood, Jean M. Moran, Jason Ocana

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To determine the limits of iodine concentration detection (LOD) and quantification (LOQ) in dual-energy computed tomography using a 3D printed phantom while considering different background, ...

Large Scale Deployment of a Tailored and Hybrid Educational Strategy for Wartime Capacity Building: Aapm/HUG/Uamp Initiative to Transition Ukraine from Co-60 to IMRT through a Comprehensive Medical Physics Training Program

Authors: Victoria Susan Ainsworth, Stephen M. Avery, Serhii Brovchuk, Thomas Brown, Sean A. Dresser, Matthew D. Goss, Viktor M. Iakovenko, Kelly Kisling, Nataliya Kovalchuk, Robert F. Krauss, Wilfred F. Ngwa, Jatinder R. Palta, Julie A. Raffi, Peter Allan Sandwall, Natalka Suchowerska, William Swanson, Shada J. Wadi-Ramahi, Ruslan Zelinskyi

Affiliation: Allegheny Hospital, Johns Hopkins University, Virginia Commonwealth University, Stanford University, O.O. Shalimov National Institute of Surgery and Transplantology, Department of Radiation Oncology, UT Southwestern Medical Center, School of Physics, The University of Sydney, MaineHealth, University of California, San Diego, Duke University, Emory University, University of Pennsylvania, University of Pittsburgh Medical Center, Medical Physics Department, Medical center of Yuriy Spizhenko, OhioHealth, University of Massachusetts Lowell, St. Francis Hospital

Abstract Preview: Purpose: The AAPM International Council, in collaboration with Help Ukraine Group (HUG) and Ukrainian Association of Medical Physicists (UAMP), developed a novel hybrid year-long training course to as...

Lesion Detection in Contrast Enhanced Cone Beam Breast CT with a Photon Counting Detector: A Monte Carlo Study

Authors: Ahad Ollah Ezzati, Xiaoyu Hu, Xun Jia, Youfang Lai, Kai Yang, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Massachusetts General Hospital, Johns Hopkins University

Abstract Preview: Purpose: Contrast-enhanced breast cone-beam computed tomography (bCBCT) provides high-resolution, 3D imaging of breast tissues with improved differentiation between normal and abnormal tissues. Curren...

Multi-Center Diffusion-Weighted MRI Validation for 0.35T MR-Linac: A Repeatability and Reproducibility Study

Authors: Tess Armstrong, Nema Bassiri, Alonso N. Gutierrez, Michael Kasper, Natalia Lutsik, Eric Mellon, Kathryn E. Mittauer, Siamak P. Nejad-Davarani, Shyam Pokharel, Suresh Rana, Hui Wang, Joseph Weygand

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, Miami Cancer Institute, Baptist Health South Florida, ViewRay, Inc., Miami Cancer Institute, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida, Department of Radiation Oncology, University of Miami

Abstract Preview: Purpose: Radiation treatments on the MR-linac (MRL) enable daily acquisition of anatomical and physiological images for adaptive treatment planning. The apparent diffusion coefficient (ADC) estimated ...

Multi-Center Evaluation of an AI Beam Angle Prediction Model for Liver Treatments Using Pencil Beam Scanning Proton Therapy

Authors: Christopher Ackerman, Chang Chang, Yan-Cheng Huang, Robert Kaderka, Che Lin, Hsin-Chih Lo, Iain MacEwan, Yi-Chin Tu, James Urbanic

Affiliation: University of California San DIego, Taiwan AI Labs, National Taiwan University, California Protons Cancer Therapy Center, University of Miami, Sylvester Comprehensive Cancer Center

Abstract Preview: Purpose: To investigate the performance of an existing AI beam angle prediction model on external patient datasets for liver proton treatments. The AI model was trained on datasets exclusively from on...

Multi-Mechanism CNN and Long Short-Term Memory Fusion Model for Improved CT-Based Thyroid Cancer Diagnosis

Authors: Yunfei Dong, Dongyang Guo, Jiongli Pan, Tao Peng, Caiyin Tang, Zhenyu Yang, Fang-Fang Yin, Lei Zhang, Tianyi Zhang, Yaogong Zhang

Affiliation: Duke Kunshan University, Department of Radiology, Taizhou People’s Hospital Affiliated to Nanjing Medical University, School of Future Science and Engineering, Soochow University, Medical Physics Graduate Program, Duke Kunshan University

Abstract Preview: Purpose: This study aims to improve the accuracy of CT-based diagnosis of thyroid cancer by developing a hybrid model that integrates Convolutional Neural Networks (CNNs) with Long Short-Term Memory (...

Neutron Dose Measurements with Multiple Dosimetry Techniques for Fetal Dose Estimation

Authors: Ahmet S. Ayan, Estelle Batin, Austin M. Faught, Peter E. Klages, Eunsin Lee, Collin Nappi, Mina Okello, Meghana Ramani, Zachary X. Richards, Parisa Sadeghi

Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, The Ohio State University Wexner Medical Center, Ohio State University, The Ohio State University

Abstract Preview: Purpose: Neutron doses are not modelled in proton treatment planning systems, so measurements were taken with two independent dosimeter types to quantify representative neutron fetal doses in pencil b...

Noise Sensitivity of Benchmark Whole-Body CT Segmentation Models: Totalsegmentator and Vista3D Performance on an Independent Dataset

Authors: Samuel L. Brady, Shruti Hegde, Alexander Knapp, Usman Mahmood, Joseph G. Meier, Elanchezhian Somasundaram, Zachary Taylor

Affiliation: Cincinnati Children's Hospital Medical Ctr, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Cincinnati Children's Hospital Medical Center, Cincinnati Childrens Hospital Med Ctr

Abstract Preview: Purpose:
To assess how two benchmark multi-organ CT segmentation models respond to varying image noise levels.
Methods:
This study utilized the pediatric CT dataset from The Cancer Imaging Ar...

Non-Invasive Photoacoustic Thermometry for Real-Time Monitoring of Tissue Temperature Using Frequency Analysis

Authors: Hisham Assi, Lexi Dowdy, Muhannad N. Fadhel, Michael C. Kolios, Carl Kumaradas, Rasha S Makkia, Tanay N Mannikar

Affiliation: Toronto Metropolitan University, Augusta University, Institute for Biomedical Engineering, Science and Technology (iBEST), Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Northwestern University, Medical College of Georgia, Augusta University

Abstract Preview: Introduction: Hyperthermia is an emerging strategy for cancer treatment due to its few side effects and low cost. Hyperthermia is used in conjunction with other treatments, such as radiation therapy, ...

Novel 3D Imaging Systems for Surgical Guidance : Loop-X and Nview S1 in Comparison with O-Arm

Authors: Jia Wang, Vani Yadav

Affiliation: Stanford University

Abstract Preview: Purpose: To evaluate the radiation dose and imaging quality of two novel CBCT X-Ray imaging systems used in spine surgeries.
Methods: CBCT scan of ACR CT and CTDI phantoms was performed to acquire ...

Objective Verification of Mechanical and Radiation Isocenters Independent of Setup

Authors: Jonathan Dowell, Wei Luo, Shane McCarthy, Janelle A. Molloy, Markus Murphy

Affiliation: University of Kentucky, Department of Radiation Medicine, Iridesce Solutions, Inc.

Abstract Preview: Purpose: The novel machine quality assurance (QA) device nĂźFilm (Iridesce Solutions, Lexington KY) allows for an objective assessment of light and radiation fields independent of setup. Herein, the ab...

On Designing a Vascular Flow Phantom for Contrast-Enhanced Ultrasound Imaging

Authors: Kevin M Brom, Josep Chorro Bas, RosaAnna Chorro Bas, Andres Climent Rubio, Jaydev K. Dave, Tobias Kummer, Larissa Shiue, Donald J Tradup

Affiliation: Mayo Clinic, Prehospital Critical Care Training Group

Abstract Preview: Purpose: To design and evaluate the functionality of a vascular flow phantom for contrast-enhanced ultrasound imaging (CEUS).

Methods: A microcontroller-generated signal was amplified by a cust...

Oncoflat: Automated 3D-to-2D Bolus Unfolding Tool for Radiation Therapy

Authors: Jeonghoon Park, Amritha Praveen, Siddhant Sen, James J. Sohn, Ethan D. Stolen

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Department of Radiation & Cellular Oncology, University of Chicago, Department of Radiation and Cellular Oncology, The University of Chicago, Department of Radiation and Cellular Oncology, University of Chicago, Department of Psychology, University of Illinois Urbana-Champaign

Abstract Preview: Purpose: Accurate fabrication of custom boluses is essential in radiation therapy to enhance dose delivery to superficial tumors, especially in anatomically complex regions. This study introduces a no...

Optimizing Quality Assurance CT Scan Frequency in Proton Therapy: Reducing Excess Dose While Maintaining Treatment Accuracy

Authors: Curtiland Deville, Rachel B. Ger, Heng Li, Todd R. McNutt

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Proton therapy patients receive quality assurance CT scans (QACTs) during treatment to verify dosimetric accuracy and determine adaptive therapy needs as proton treatments are highly sensitiv...

Optimizing Timing of Physics Consults for Proton Prostate Therapy: Improving Patient Experience and Operational Efficiency

Authors: Charles D. Bloch, Stephen R. Bowen, Bing-Hao Chiang, Alex Egan, Eric C. Ford, Sharareh Koufigar, Dominic A. Maes, Juergen Meyer, Sharon Pai, Frank Rafie, Rajesh Regmi, Jatinder Saini, George A. Sandison, Marco Schwarz, Bishwambhar Sengupta, Tony P. Wong

Affiliation: Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Department of Physics, University of Washington

Abstract Preview: Purpose: This study aimed to optimize the strategy and timing of physics consults for proton prostate patients to improve the patient experience and resource utilization in our radiation oncology depa...

Patient-Specific Imaging Modality Agnostic Virtual Digital Twins Modeling Temporally Varying Digestive Motion

Authors: James M. Balter, Lando S. Bosma, Jorge Tapias Gomez, Nishant Nadkarni, Mert R Sanbuncu, William Paul Segars, Ergys D. Subashi, Neelam Tyagi, Harini Veeraraghavan

Affiliation: University of Michigan, The University of Texas MD Anderson Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Carl E. Ravin Advanced Imaging Laboratories and Center for Virtual Imaging Trials, Duke University Medical Center, Cornell University, University Medical Center Utrecht, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Develop patient-specific virtual digital twin (VDT) cohorts modeling physically realistic spatio-temporal gastrointestinal (GI) organs (stomach and duodenum) digestive motion.
Methods: Pat...

Patterns of Nanoparticle Uptake for Patients with Multiple Brain Metastases: Similarities and Differences to Standard Gbca

Authors: Stephanie Bennett, Ross I. Berbeco, Ning Jin, Sonal Josan, Justin Michael Sheetz, Atchar Sudhyadhom

Affiliation: Department of Radiation & Cellular Oncology, University of Chicago, University of Massachusetts - Lowell, Siemens Healthineers, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Brigham and Women's Hospital

Abstract Preview: Purpose: AGuIX, a Gadolinium-based theranostic radiosensitizing nanoparticle, is currently under clinical evaluation in Europe and the US. Using patients from the double-blinded NanoBrainMets trial, u...

Photon-Proton Treatment Compatible Couch Tops Render Modality-Dependent Support Structure Models

Authors: Estelle Batin, Michael A. Carlson, Nilendu Gupta, Zachary X. Richards, Diana Shvydka

Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center

Abstract Preview: Purpose: With an increase in world-wide proton treatment availability, patients sometimes are transferred between proton and photon modalities. Among the main reasons for modality shifts are proton be...

Posterior-Mean Diffusion Model for Realistic PET Image Reconstruction

Authors: Osama R. Mawlawi, Yiran Sun

Affiliation: RICE University, UT MD Anderson Cancer Center

Abstract Preview: Purpose: Conventional PET reconstruction methods often produce noisy images with artifacts due to data/model mismatches and inconsistencies. Recently, deep learning-based conditional denoising diffusi...

Prostate Dosimetric Comparison between Cyberknife and Radixact Modalities Using Precision and Raystation Planning Systems

Authors: Mireille Conrad, CĂŠdric De Marco, Marie Fargier-Voiron, Maud Jaccard, Oscar Matzinger, Nicolas Joel Lionel Perichon

Affiliation: Clinique De Genolier

Abstract Preview: Purpose: The Accuray Synchrony real-time motion fiducial tracking solution allows for prostate stereotactic treatment on both Cyberknife and Radixact machines. In our radiotherapy department, two solu...

Proton Minibeam Radiotherapy: Commissioning, Treatment Planning, and Delivery

Authors: Stephen M Corner, Daiki Hara, Jiasen Ma, Robert W Mutter, Mark D. Pepin, Nicholas B. Remmes, Hok Seum Wan Chan Tseung

Affiliation: Mayo Clinic - Rochester

Abstract Preview: Purpose: Proton minibeam radiotherapy (pMBRT) is a form of spatially fractionated radiation therapy leveraging submillimeter beams to improve the therapeutic ratio. We report on collimator design, com...

Quality Assurance of Four-Dimensional Computed Tomography (4DCT)

Authors: Teh Lin, Anna Oneil

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose: Four-dimensional computed tomography(4DCT) is often required to assess organ motions for thoracic and abdominal cancer patients. This study proposes a quality assurance (QA) procedure for two...

Quantification of Chemical Species Yield and Radiation Damage Patterns for Radiopharmaceutical Therapy Isotopes: Lu-177, Y-90 and I-131

Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal

Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology

Abstract Preview: Purpose: The fundamental concept of radiopharmaceutical therapy involves binding radioisotopes to molecules with a known biokinetic distribution, which ensures that the targeted organs receive higher ...

Radio-Immune Response Model for the Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR)

Authors: Young-Bin Cho, Robert Timmerman

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, Cleveland Clinic

Abstract Preview: Purpose: Immunologically hot (MC38) and cold (LLC) tumor in mouse were treated with radiation and/or immunotherapy agent for the study of Personalized Ultrafractionated Stereotactic Adaptive Radiother...

Radiochemical Monte Carlo Model to Investigate the Oxygen Impacts on Radical Yields Under Proton Flash Irradiation

Authors: Yao Hao, Yuting Peng, Francisco Javier Reynoso, Tianyu Zhao, Xiandong Zhao

Affiliation: Varian, University of South Florida, Washington University School of Medicine, Washington University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose: Ultra-high dose-rate (FLASH) dose rate (> 40 Gy/s) may result in a radio-protective effect in healthy tissue compared with conventional dose rate (CDR). This effect has been observed in vivo ...

Real-Time Automatic Treatment Planning System (RT-AutoTPS) for Volumetric Modulated Arc Radiotherapy (VMAT)

Authors: Steve B. Jiang, Austen Matthew Maniscalco, Dan Nguyen, Chenyang Shen, Jiacheng Xie, Shunyu Yan, Ying Zhang, You Zhang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Lab & Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center, The University of Texas at Dallas

Abstract Preview: Purpose: Although treatment planning systems (TPSs) can handle dose calculation and plan optimization automatically, planning for radiotherapy still requires extensive efforts and expertise from a mul...

Robustness of Deep Learning-Based Motion Compensated 4D-CBCT Reconstruction to out-of-Distribution Data

Authors: Geoffrey D. Hugo, Eric Laugeman, Thomas R. Mazur, Pamela Samson, Kim A. Selting, Zhehao Zhang

Affiliation: University of Illinois, Washington University in St. Louis School of Medicine, WashU Medicine

Abstract Preview: Purpose: To investigate the robustness of a deep learning (DL)-based 4D-CBCT motion-compensated (MoCo) reconstruction method to out-of-distribution data.
Methods: Our developed 4D-CBCT reconstructi...

Robustness of Jacobian-Based and HU Change-Based CT Ventilation Imaging to Respiratory Amplitude Variations: A Study Using a Custom Phantom with Respiratory Amplitude Control

Authors: Tatsuya Fujisaki, Hiraku Fuse, Shin Miyakawa, Hiroki Nosaka, Masato Takahashi, Kenji Yasue

Affiliation: Ibaraki Prefectural University of Health Sciences

Abstract Preview: Purpose: This study aimed to evaluate the robustness of Jacobian-based and HUchange-based CT ventilation imaging (CTVI) against respiratory amplitude variations using a custom-designed alveolar phanto...

Scan Efficiency and Imaging Dose Analysis of Next-Generation Nonstop Gated CBCT for Respiratory Gating Lung Radiotherapy

Authors: Sean L. Berry, Weixing Cai, Laura I. Cervino, Yusuf Emre Erdi, Yabo Fu, Yiming Gao, Daphna Gelblum, Wendy B. Harris, Xiuxiu He, Tianfang Li, Xiang Li, Seng Boh Gary Lim, Jean M. Moran, Mitchell Yu, Hao Zhang

Affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Gated CBCT (gCBCT) is commonly employed for respiratory gating lung cancer patients to ensure precise patient setup. However, the scan is time-consuming on C-arm linear accelerators (LINAC) d...

Spectrometry-Based Determination of X-Ray Tube Endpoint Potentials

Authors: Wesley S. Culberson, Ryan Gardner, John Thomas Stasko

Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin

Abstract Preview: Purpose: X-ray tube voltage is a critical parameter in influencing an X-ray tube’s beam quality. The endpoint tube potential, the potential difference between the X-ray tube’s cathode and anode, is pa...

Spot Map Modification for Planning Optimization on a Spot Scanning Proton System with Adaptive Aperture

Authors: Austen N. Curcuru, Winter Green, Yao Hao, Jiayi Liu, Yuting Peng, Tiezhi Zhang, Xiandong Zhao

Affiliation: Washington University School of Medicine, Department of Radiation Oncology, WashU Medicine, Virginia Commonwealth University, Washington University School of Medicine, Washington University in St. Louis

Abstract Preview: Purpose: We proposed a treatment planning optimization method that utilizes customized spot map modification to achieve less dosimetry uncertainty, monitor unit ratio (MUR) and neutron dose in a spot ...

Supercomputing-Enabled CT Virtual Imaging Trials: A Population-Scale Pilot Study

Authors: Ehsan Abadi, Zakaria Aboulbanine, Nicholas D Felice, David Fenwick, Anuj J. Kapadia, Cindy Marie McCabe, Jayasai Ram Rajagopal, Ehsan Samei

Affiliation: Duke University, Oak Ridge National Laboratory, Center for Virtual Imaging Trials, Duke University, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System

Abstract Preview: Purpose:
Virtual imaging trials (VITs) offer a computational alternative to clinical imaging trials leveraging virtual patients, scanners, and interpreters to assess imaging questions. To provide m...

TCP Modeling of Regional Recurrencies and Dose to Nodal GTV after Radiotherapy for Head & Neck Cancer

Authors: Brian M. Anderson, Simon A. Brundage, Xuguang Scott Chen, Shiva K. Das, Felice Dong, Spencer Lynch, Panayiotis Mavroidis, Ryan Morse Morse, Heidi Urquidi

Affiliation: University of North Carolina Chapel Hill, University of North Carolina at Chapel Hill, University of North Carolina

Abstract Preview: Purpose: This study aims at correlating different dosimetric indices of nodal GTV with the regional recurrencies observed after head and neck radiotherapy. Also, to perform a tumor control probability...

Task Specific Image Quality Assessment Using Spectral Photon-Counting CT.

Authors: Azza Mohamed Ahmed, Nadine Francis, Osama Khan, Nabil Maalej, Aamir Raja, Briya Tariq

Affiliation: Khalifa University

Abstract Preview: Purpose: The study aims to evaluate the task-specific diagnostic performance of spectral photon-counting CT (SPCCT) using application-specific phantoms.
Methods:
Parameters such as linearity res...

The Analysis of the Bifurcation from Immune-Limited to Immune-Escape Mode in Tumor Size

Authors: Young-Bin Cho, Jacob Scott, Nara Yoon

Affiliation: Adelphi University, Cleveland Clinic

Abstract Preview: Purpose: The immune system plays a critical role in determining cancer prognosis. Based on our prior study (Cho et al., 2023) about the bystander effect induced by immune responses in spatially design...

The Effect of Radiotherapy Structure Shape Features on the Accuracy of Their Digital Representation and Manipulation

Authors: Annie Cooney, Kenneth L. Homann, Somayeh Taghizadehghahremanloo, Adam D. Yock, Hong Zhang

Affiliation: Assistant Professor, Vanderbilt University Medical Center

Abstract Preview: Purpose:
Digital radiotherapy data has been standardized using the DICOM format. However, different radiotherapy software environments interpret identical data differently due to inherent software ...

The Impact of Implant Position and Different Radiotherapy Techniques on Dosimetry in Post-Mastectomy Breast Reconstruction for Breast Cancer

Authors: Xiu tong Lin

Affiliation: Department of Radiation physics and technology, Shandong Second Provincial General Hospital

Abstract Preview: Purpose: To compare the dosimetric differences between the photon and proton plans and between the different target according to the placement of the implants for patients undergoing radiotherapy afte...

The Impact of Intempo Imaging on Cyberknife Prostate Plans

Authors: Lei Fu, Eric Gressen, Yingcui Jia, Shari Rudoler, Yevgeniy Vinogradskiy, Qianyi Xu

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: InTempo imaging in the Accuray CyberKnife System improves the ability to track/correct target motion during treatment. However, no studies have provided information on the impact of InTempo I...

The Role of AI-Based Analysis in Segmenting Sealing Zones and Tissue Characterization

Authors: Sara Allievi, Stefano Bonvini, Gloria Miori, Laura Orsingher, Andrea Passerini, Igor Raunig, Daniele Ravanelli, Erich Robbi, Annalisa Trianni

Affiliation: Department of Information Engineering and Computer Science, University of Trento, Vascular Surgery Department, S.Chiara Hospital, APSS, Medical Physics Department, S.Chiara Hospital, APSS

Abstract Preview: Purpose:
This study evaluates the performance of an AI-driven tool in segmenting and analyzing tissue composition in abdominal aortic aneurysm (AAA) patients, specifically focusing on the sealing z...

Time and Energy-Encoded CT Reconstruction

Authors: Shusen Jing, Qihui Lyu, Dan Ruan, Ke Sheng, Qifan Xu

Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Conventional computed tomography (CT) measures the collective attenuation of primary photon fluence and then reconstructs the 3D images without using the timing information of individual phot...

Time-Efficient Photon Plan Checks with Esapi-Based Software

Authors: Kevin Peter Risolo

Affiliation: University of Pennsylvania

Abstract Preview: Purpose: To quantify the improved efficiency of checking patient treatment plan MU by utilizing RadFormation’s ClearCalc script-based program.
Methods: A total of 58 patients planned for treatment ...

Topas-Nbio – Status and Outlook after a Decade of Developments

Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Kathryn D Held, Nicolas Henthorn, Jay LaVerne, Thongchai Masilela, Stephen J. McMahon, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin, Michael Taylor, John Warmenhoven

Affiliation: Massachusetts General Hospital, Queen's University Belfast, Massachusetts General Hospital and Harvard Medical School, University of California San Francisco, University of Manchester, Notre Dame University

Abstract Preview: Purpose: TOPAS-nBio brings a cutting-edge Monte Carlo (MC) simulation framework to the research community to test hypotheses of radiation effects at the nanometer/cell scale. Here, we present the deve...

Two Radiochemical Monte Carlo Models to Investigate the Radical Yields Under Proton Flash Irradiations

Authors: Yujie Chi, Yao Hao, Xun Jia, Youfang Lai, Yuting Peng, Francisco Javier Reynoso, Lingshu Yin, Tianyu Zhao, Xiandong Zhao

Affiliation: Johns Hopkins University, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Physics, University of Texas at Arlington, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, University of South Florida

Abstract Preview: Purpose: FLASH radiation therapy has shown remarkable tissue sparing effects compared to radiation therapy at conventional dose rates (CDR). Yet, its mechanism remains unclear. Radical production modu...

Utilizing All Acquired Images from Fluoroscopically-Guided Interventions: Test Application with Event-By-Event Patient Dosimetry Calculations

Authors: Sagine Berry-Tony, Lasya Daggumati, James R Duncan, Melak Senay, Allan Thomas

Affiliation: University of Missouri-Kansas City School of Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Washington University in St. Louis

Abstract Preview: Purpose: Most acquired images in FGIs are not permanently archived. In the context of modern computational prowess, novel improvements to FGI practice likely sit just under the surface of large-scale ...

Validation of 3D Pseudo-Dose Map Reconstructed from Multi-View Cherenkov Images in Total Skin Electron Therapy

Authors: Brook Byrd, Lisha Chen, Michael LaRiviere, Baozhu Lu, John Plastaras, Brian W Pogue, Emily Xiong, Timothy C. Zhu, Yifeng Zhu

Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania, University of Wisconsin - Madison

Abstract Preview: Purpose: For total skin electron therapy (TSET), achieving optimal dose distribution depends on precise patient positioning, which is often influenced by daily variability. Cherenkov imaging offers a ...

Variations in Automatic Dose Response Curves across Fluoroscope Types and Manufacturers for Abdominal Imaging

Authors: Hadley Anna DeBrosse, Edward J. Stafford, Kevin A. Wunderle

Affiliation: Ohio State University, The Ohio State University

Abstract Preview: Purpose: To investigate automatic dose response curves from fluoroscopes across multiple manufacturers for an abdominal imaging protocol.
Methods: ADRC response for multiple fluoroscopes were evalu...

Variations in Radiation Isocenter Offsets from the Winston-Lutz Test Performed on Different Photon Energies

Authors: Cambridge L Bui-Nguyen, Alexander S. Nguyen, Liqiang (Lee) Tao

Affiliation: Varian AOS @Epic Care, UC Berkeley

Abstract Preview: Purpose: To quantity variations in Winston Lutz (WL) test results due to different energies used in SBRT, SRT or SRS.
Methods: A WL phantom with a 6.4 mm diameter center radio-opaque sphere is used...

Visualization of Irradiation Field in Carbon-Ion Therapy By Openpet: Preliminary Analysis of Clinical Data

Authors: Go Akamatsu, Hiroaki Ikawa, Yuma Iwao, Han Gyu Kang, Masashi Koto, Hideyuki Mizuno, Akram Mohammadi, Makoto Shinoto, Minoru Tajiri, Hideaki Tashima, Chie Toramatsu, Taiga Yamaya

Affiliation: National Institutes for Quantum Science and Technology

Abstract Preview: Purpose: In-beam positron emission tomography (PET), in which positron emitters produced through fragmentation reactions are visualized, is a practical method for range verification in particle therap...

Volumetric-Modulated Arc Therapy (VMAT) Is Associated with Improved Dose Homogeneity, but More Normal Tissue Irradiation Compared to Three-Dimensional Conformal Radiation Therapy (3DCRT) for Breast Cancer

Authors: Laura I. Cervino, Linda X. Hong, Jessica Pagan, Angelica A. Perez-Andujar, Maria Thor

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan-Kettering Cancer Center

Abstract Preview: Purpose: Three-dimensional conformal radiotherapy (3DCRT) and Volumetric-Modulated Arc Therapy (VMAT) are used to treat locally advanced breast cancer. The 3DCRT treatment plans use the treatment fiel...