Authors: Arpit M. Chhabra, J Isabelle Choi, Minglei Kang, Haibo Lin, Hang Qi, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Xingyi Zhao, Ajay Zheng
Affiliation: New York Proton Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose:
Pencil beam scanning (PBS) proton therapy effectively treats ocular cancer by minimizing exit doses to normal tissues. However, challenges remain in sparing nearby organs-at-risk(OARs). Ul...
Authors: Ramin Abolfath, Sedigheh Fardirad, Abbas Ghasemizad, Houda Kacem, Marie Catherine Vozenin
Affiliation: University of Guilan, Universite de Lausanne, University Hospital, Geneva, Howard University
Abstract Preview: Purpose: Lower production of H2O2 in water is a hallmark of ultra-high dose rate (UHDR) compared to the conventional dose rate (CDR). The current computational models are in the opposite of the experi...
Authors: Lu Jiang, Shusen Jing, Qihui Lyu, Dan Ruan, Ke Sheng, Qifan Xu
Affiliation: Department of Radiation Oncology, University of California, Los Angeles, University of California San Francisco, Department of Radiation Oncology, University of California at San Francisco, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose: In radiotherapy, the conformity and compactness of dose distribution are vital to patient outcomes. The introduction of highly complex planning, such as 4π radiotherapy, has provided a system...
Authors: Santosh K. Agarwalla, Nrusingh C. Biswal, Shree C, Harikrishnan Suresh Kumar, Jajati K. Nayak, Prema P., Sarath K S, Tamil Selvan S, Hem D. Shukla
Affiliation: Variable Energy Cyclotron Centre, Department of Physics, Fakir Mohan University, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Sciences, Amrita Vishwa Vidyapeetham
Abstract Preview: Purpose: The rapid oxygen depletion in tissues during irradiation is the most accepted mechanism of the FLASH effect. However, the Normal Tissue Complication Probability (NTCP) and Tumor Control Proba...
Authors: Javier Chiasson, Dominique Guillet, Arthur Lalonde, Karim Zerouali
Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal
Abstract Preview: Purpose:
To validate a Monte Carlo (MC) model of a Ultra-High dose rate (UHDR) electron beam using a prototype flashdiamond (fD) detector coupled to an electrostatically shielded beam current trans...
Authors: Muhammad Ramish Ashraf, Dixin Chen, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner
Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: Precise beam collimation is essential in preclinical radiotherapy studies to ensure accurate dose delivery. Manual design and fabrication of organ-specific collimators usually consist of mult...
Authors: David J. Gladstone, P. Jack Hoopes, David I Hunter, Brian W Pogue, Jacob Pierce Sunnerberg, Armin Tavakkoli
Affiliation: Thayer School of Engineering, Dartmouth College, University of Wisconsin - Madison, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Geisel School of Medicine, Dartmouth College
Abstract Preview: Purpose: The FLASH effect, characterized by normal tissue sparing under ultra-high dose rate (UHDR) radiation delivery, remains mechanistically unclear. This study investigated the relationship betwee...
Authors: Jiayi Du, Lihua Jin, Ke Sheng, Yu Zhou
Affiliation: Harvard University, University of California, San Francisco, UCLA, Department of Radiation Oncology, University of California, San Francisco
Abstract Preview: Purpose: Radiomics enables powerful insights into tumor biology through non-invasive imaging, excelling in diagnostic and prognostic predictions. However, due to a lack of mechanistic connections, que...
Authors: Ronald C Chen, Hao Gao, Nicolas Gerard, Harold Li, Yuting Lin, Jarrick Nys, Jufri Setianegara, Mark Szczepanski, Aoxiang Wang
Affiliation: 4Physikalisch-Technische Werkstätten (PTW), Department of Biomedical Engineering, Huazhong University of Science and Technology, Ion Beam Applications (IBA), Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Modern synchrocyclotrons can produce magnetically-scanned protons at ultra-high dose-rates (FLASH). However, their pulsed nature leads to high doses-per-pulse (DPP) which can cause non-neglig...
Authors: Dominique Guillet, Arthur Lalonde, Bryan R. Muir, James Renaud, Karim Zerouali
Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal, National Research Council
Abstract Preview: Purpose:
To evaluate the dose rate dependence, beam quality dependence, and short-term stability of a novel flashDiamond (fD) prototype detector for conventional and ultra-high dose rate (UHDR) bea...
Authors: Gulakhshan M Hamad, Sina Mossahebi, Yannick P. Poirier, Amit Sawant
Affiliation: University of Maryland School of Medicine, Maryland University Baltimore
Abstract Preview: Purpose:
The combination of ultra-high dose rate (UHDR) proton therapy, known for normal tissue sparing, with spatially-fractionated radiotherapy (SFRT), promising enhanced tumor control and tissue...
Authors: Ahmet S. Ayan, Austin M. Faught, Eunsin Lee, Julia Pakela
Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Ohio State University, The Ohio State University
Abstract Preview: Purpose: To present commissioning of a fixed beamline ultra-high dose rate proton pencil beam scanning system, the world’s first multi-room Varian ProBeam360⁰
Methods: The fixed beamline pencil bea...
Authors: Julien Forthomme, Carolina Llina Fuentes, Valentin Hamaide, Lucian Hotoiu, Rudi Labarbe, Rasmus Nilsson, Arnaud Pin, Francois Vander Stappen, Erik Traneus
Affiliation: RaySearch Laboratories AB, Ion Beam Applications SA
Abstract Preview: Purpose: Conformal FLASH achieves ultra-high-dose-rate (UHDR) proton therapy (>40 Gy/sec) by scanning a mono-energetic pencil beam through accessories (range shifter, Conformal Energy Modulator, apert...
Authors: Alexander Baikalov, Luke Connell, Nicholas Coupey, Nolan M. Esplen, Rebecca Lim, Chinh Nguyen, Emil Schueler
Affiliation: Northwell, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: FLASH radiotherapy delivered using electron linear accelerators (LINAC) requires precise control and minimal variation of dose rate and We developed a robust external beam control system (EBC...
Authors: Zongsheng Hu, Yuting Li, Radhe Mohan, Emil Schueler, Uwe Titt
Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: In previous work, we developed an irradiation system for pre-clinical ultra-high-dose-rate(FLASH) radiotherapy experiments based on synchrotron proton beamline. However, the beam current limi...
Authors: Javier Chiasson, Dominique Guillet, Arthur Lalonde, Bryan R. Muir, James Renaud, Karim Zerouali
Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal, National Research Council
Abstract Preview: Purpose: To develop, optimize and validate a novel applicator for ultra-high dose rate (UHDR) electron radiotherapy incorporating an electrostatically shielded beam current transformer (BCT) for real-...
Authors: Somayeh Gholami, Saeedeh Ketabi, Jeremy Kunz, Ali Yousefi
Affiliation: Department of Radiation Oncology, University of Utah, University of Utah, Department of Management- Operations Research, University of Isfahan
Abstract Preview: Purpose: This paper aims to present a novel approach for automatic knowledge-based planning optimization for Intensity Modulated Radiotherapy, along with the two downsizing techniques for improving th...
Authors: Luke Connell, Nolan M. Esplen, Elise Konradsson, Albert C. Koong, Ziyi Li, Steven Hsesheng Lin, Kevin Liu, Billy W Loo, Devarati Mitra, Radhe Mohan, Emil Schueler, Takeshi Takaoka, Uwe Titt, Xiaochun Wang, Ming Yang
Affiliation: The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: This study aimed to assess radiation-induced gastrointestinal (GI) toxicity in mice subjected to abdominal irradiation using protons at ultra-high-dose-rate (UHDR) and conventional dose-rates...
Authors: Lily Jo Bertemes, Careesa Billante, Ashley Cetnar, Arnab Chakravarti, Nilendu Gupta, Sagarika Jain, Maximilian Stephen Meineke, Allison N. Palmiero, Runhe Tan
Affiliation: The Ohio State University - James Cancer Hospital, Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center, The Ohio State University, The James Cancer Center
Abstract Preview: Purpose: Ultra-High Dose Rate Radiation Therapy (UHDR-RT) induces normal tissue sparing while maintaining iso-effective tumor control compared to conventional methods, known as the “FLASH effect”. How...
Authors: Chin-Cheng Chen, Chingyun Cheng, Longfei Diao, Benjamin Durkee, Minglei Kang, Haibo Lin, LeLe Liu, Yangguang Ma, Xuanqin Mou, YunTong Pei, Charles B. Simone, YuFei Wang, Xueqing Yan, Xingyi Zhao, Wang Zhengda
Affiliation: Peking University, St. Jude Children's Research Hospital, New York Proton Center, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, School of Software Engineering, Xi’an Jiaotong University, School of information and communications engineering, Faculty of electronic and information engineering, Xi’an Jiaotong University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose: This study evaluates the effectiveness of apertures in improving lateral dose falloff in proton pencil beam scanning (PBS) single-energy Bragg peak (SEBP) FLASH radiotherapy (RT). The approac...
Authors: Jack Biondo, Audrey Magness, Anthony E. Mascia, Zhiyan Xiao, Yongbin Zhang
Affiliation: Cincinnati Children's Proton Therapy Center
Abstract Preview: Purpose: Proton FLASH-RT has shown promise reducing normal tissue toxicity while maintaining tumor control. However, in vivo experiments critically depend on achieving ultra-high dose rate (UHDR) and ...
Authors: Mervat A. Alharbi, Wesley S. Culberson
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Medical Physics Department, School of medicine and Public Health, University of Wisconsin-Madison
Abstract Preview: Purpose: The charge collection using ionization chambers is challenging at ultra-high dose rates (UHDR) due to the high ion recombination The Exradin A30 prototype parallel-plate ion chamber manufactu...
Authors: Julie Colnot, Eric Deutsch, Christelle Huet, Danahé LeBlanc, Pauline Maury, Charlotte Robert, Imane Saïd Mansour, Cathyanne Schott, Francois Therriault-Proulx
Affiliation: INSERM U1030, Gustave Roussy, University Paris-Saclay, LDRI, IRSN, Medscint, THERYQ / INSERM U1030, Gustave Roussy, University Paris-Saclay, Université Paris-Saclay, Gustave Roussy, Inserm U1030, Radiothérapie Moléculaire et Innovation Thérapeutique
Abstract Preview: Purpose: FLASH radiotherapy, using ultra-high dose rates (UHDR, >100 Gy/s), spares healthy tissues while maintaining tumor control compared to conventional radiotherapy (CONV). However, UHDR dosimetry...
Authors: Girish Bal, Thomas I. Banks, Bin Cai, Neil Desai, Aurelie Garant, Orhan Oz, Elizeva Phillips, Rameshwar Prasad, Chenyang Shen, Robert Timmerman
Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center, University of Texas Southwestern Medical Center, UT Southwestern Medical Center, RefleXion Medical
Abstract Preview: Purpose: This study reports findings from the first-in-human imaging-only trial evaluating the feasibility of using the novel PET tracer 68Ga-PSMA-11 (Illuccix) to guide external beam radiotherapy on ...
Authors: Xu Cao, Wesley S. Culberson, Aleksandra Ilina, Kendall Jarvis, Brian W Pogue, Matthew Reed, William Scott Thomas, Nathaniel Van Asselt, Albert van der Kogel
Affiliation: University of Wisconsin: Madison, University of Wisconsin: Madison School of Veterinary Medicine, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin–Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose: While FLASH radiotherapy is known to reduce skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR). Currently it is not clear whether this ...
Authors: Xu Cao, Wesley S. Culberson, Aubrey Parks, Brian W Pogue, Matthew Reed, William Scott Thomas
Affiliation: University of Wisconsin: Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose: Under Ultra-High Dose Rate (UHDR) irradiation, radical-radical interactions are likely enhanced due higher density production in time and space and this alters the cascade of reactions that s...
Authors: Ning Cao, Sunan Cui, Danielle P. Johnson Erickson, Juergen Meyer, Ramesh Rengan, Ben A Shaver, Jing Zeng
Affiliation: Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, University of Washington and Fred Hutchinson Cancer Center, University of Washington
Abstract Preview: Purpose: To investigate the immune response in primary irradiated tumors and non-irradiated tumors in a mouse melanoma xenograft model, comparing 18Gy of conventional (CONV) and ultra-high dose rate (...
Authors: Xu Cao, Wesley S. Culberson, Aubrey Parks, Brian W Pogue, William Scott Thomas
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose:
The hydrated electron is a critical reactive species generated during the radiolysis of water when ionizing radiation interacts with biological tissues. It plays a pivotal role in mediatin...
Authors: Ramin Abolfath, Alexander Baikalov, Stefan Bartzsch, Nolan M. Esplen, Alan Eduardo Lopez Hernandez, Emil Schueler
Affiliation: MD Anderson Cancer Center, PI Experimental Medical Physics, Institute of Radiation Medicine (IRM), Helmholtz Munich, Germany, Howard University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: FLASH radiation therapy (FLASH-RT) leverages ultra-high dose rates (UHDR) to spare normal tissue as compared to conventional (CONV)-RT while preserving tumor control; this is termed the FLASH...
Authors: Konstantinos Chatzipapas, George C. Kagadis, Panagiotis Konstas, Dimitris N. Mihailidis, Dimitris Visvikis
Affiliation: LaTIM, INSERM UMR1101, University of Pennsylvania, LaTIM, INSERM, University of Brest, University of Patras
Abstract Preview: Purpose: This study investigates the temporal evolution of radiolytic species (H3O+, OH•, OH-) in water under electron and proton irradiation using the mesoscopic chemistry model that allows longer te...
Authors: Hao Gao, Jiayue Han, Wangyao Li, Yuting Lin, Jufri Setianegara, Aoxiang Wang, Yanan Zhu
Affiliation: Department of Biomedical Engineering, Huazhong University of Science and Technology, Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Proton therapy leverages Bragg-peak-based dose delivery to achieve ultra-high-dose-rate FLASH with patient-specific range modulators (PSRM). Current proton FLASH (pFLASH) planning typically i...
Authors: Liang Cui, Xingyu Lu, Hang Shang, LingHong Zhou
Affiliation: Southern Medical University
Abstract Preview: Purpose: This study examines how varying dose rates of radiotherapy impact normal tissues outside the target area and analyzes the protective effects and regulatory mechanisms of ultra-high dose rate ...
Authors: Michael M Folkerts, Miriam Krieger, Pierre Lansonneur, Gerard Paquet, Petar Penchev, Christoph Schuy, Yuri Simeonov, Uli Weber, Klemens Zink
Affiliation: GSI Helmholtzzentrum fuer Schwerionenforschung, Institute of Medical Physics and Radiation Protection (IMPS), University of Applied Sciences, Varian Medical Systems
Abstract Preview: Purpose:
Ultra-high dose-rate proton irradiation may spare the healthy tissue (FLASH-effect). The 3D-range-modulator (3D-RM) method reduces the treatment time compared to conventional IMPT and can ...
Authors: Rafael Carballeira, David J. Gladstone, Philippe Liger, Rongxiao Zhang
Affiliation: TheryQ, Dartmouth College, University of Missouri, Thayer School of Engineering, Dartmouth College
Abstract Preview: Purpose: To model a FLASH electron beam system (FLASHLAB) via first principle Monte Carlo methods, navigating installation configurations, shielding and regulatory radiation safety considerations for ...
Authors: Karyn A Goodman, Yang Lei, Tian Liu, Charlotte Elizabeth Read, Jing Wang, Qian Wang, Jiahan Zhang
Affiliation: Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology, Beth Israel Deaconess Medical Center
Abstract Preview: Purpose: Accurate motion management in MRI-guided radiotherapy (MRIgRT) relies on real-time volumetric MRI to track intra-fractional anatomical changes. Dense k-space sampling, while capable of produc...
Authors: Wesley S. Culberson, Aleksandra Ilina, Brian W Pogue, Matthew Reed, Connor Strainis, William Scott Thomas, Nathaniel Van Asselt, Albert van der Kogel
Affiliation: University of Wisconsin: Madison, University of Wisconsin: Madison School of Veterinary Medicine, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin–Madison, University of Wisconsin-Madison, University of Wisconsin - Madison
Abstract Preview: Purpose: FLASH radiotherapy reduces skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR), while preserving damage to tumor tissue. The FLASH effec...
Authors: Ashok Bhandari, Andrew Joseph Fanning, Kyle J. Gallagher, Brendan Graff, Christopher Jenkins, Kyuhak Oh, Ying Yan, Su-Min Zhou
Affiliation: University of Nebraska Medical Center
Abstract Preview: Purpose: This study aimed to design a robust experimental setup to ensure accurate dose delivery using ultra-high-dose-rate for small animal experiments by conducting dosimetric evaluations prior to a...
Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng
Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison
Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...
Authors: Alexandru Badalan, Peter Petric, I. Antoniu Popescu, Andrew Kyle Henderson Robertson
Affiliation: Bc Cancer, BC Cancer - Vancouver, BC Cancer
Abstract Preview: Purpose: Ultra-high dose rate (>40 Gy/s) or “FLASH” radiation therapy (RT) has the potential to improve cancer treatment through reduced radiation side effects. While electron FLASH beams can be produ...
Authors: Yao Hao, Yuting Peng, Francisco Javier Reynoso, Tianyu Zhao, Xiandong Zhao
Affiliation: Varian, University of South Florida, Washington University School of Medicine, Washington University School of Medicine, Department of Radiation Oncology
Abstract Preview: Purpose: Ultra-high dose-rate (FLASH) dose rate (> 40 Gy/s) may result in a radio-protective effect in healthy tissue compared with conventional dose rate (CDR). This effect has been observed in vivo ...
Authors: Muhammad Ramish Ashraf, Dixin Chen, Aaron Garza, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner, Murat Surucu
Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: FLASH radiotherapy, supported by robust preclinical evidence showing an improved therapeutic index, is advancing toward clinical trials. Clinical FLASH treatments will likely require scanning...
Authors: Hadley Anna DeBrosse, Kevin J. Little
Affiliation: The Ohio State University
Abstract Preview: Purpose: This work examines the consistency and pattern of spatial resolution degradation in weekly quality control (QC) testing prior to CT tube failure and replacement and investigates potential cor...
Authors: Alejandro Bertolet, Jorge Naoki Dominguez Kondo, Bruce A. Faddegon, Kathryn D Held, Nicolas Henthorn, Jay LaVerne, Thongchai Masilela, Stephen J. McMahon, Isaac Meyer, Victor V. Onecha, Harald Paganetti, Jose A. Ramos-Mendez, Jan PO Schuemann, Wook-Geun Shin, Michael Taylor, John Warmenhoven
Affiliation: Massachusetts General Hospital, Queen's University Belfast, Massachusetts General Hospital and Harvard Medical School, University of California San Francisco, University of Manchester, Notre Dame University
Abstract Preview: Purpose: TOPAS-nBio brings a cutting-edge Monte Carlo (MC) simulation framework to the research community to test hypotheses of radiation effects at the nanometer/cell scale. Here, we present the deve...
Authors: Petr Bruza, Rafael Carballeira, Megan Clark, David J. Gladstone, Austin Sloop, Roman Vasyltsiv, Kevin Jacob Willy
Affiliation: Dartmouth College, Thayer School of Engineering, Dartmouth College
Abstract Preview: Purpose: Develop an optical dosimetry system to accomplish standard of care on-patient dosimetry and pretreatment quality assurance for ultra-high dose rate (UHDR) electron therapy ahead of human tria...
Authors: Guangjun Li, Ying Song, Huanan Tang, Tianxiong Wu, Qiuyi Ye, Wei Zhang
Affiliation: West China Second Hospital of Sichuan University, United Imaging Healthcare, West China Hospital of Sichuan University
Abstract Preview: Purpose:
To propose a general low-dose reconstruction model for ultra-sparse-view cone-beam CT (CBCT) and evaluate its clinical application in improving image quality and reducing radiation dose fo...
Authors: Joao Seco
Affiliation: Department of Physics and Astronomy, Heidelberg University
Abstract Preview: N/A...