Authors: Fu-Xiong Chang, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Nancy Y Lee, Chih-Hsun Lin, Haibo Lin, Hang Qi, Mahbubur Rahman, Charles B. Simone, Pingfang Tsai, Shouyi Wei, Irini Yacoub, Yunjie Yang, Ajay Zheng, Jun Zhou
Affiliation: New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, Liverage Biomedical Inc., Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Institute of Physics, Academia Sinica
Abstract Preview: Purpose: FLASH therapy presents an opportunity to alter the radiotherapy paradigm and significantly enhancing normal organ protection while maintaining the effectiveness of tumor control. The temporal...
Authors: Wenhua Cao, Xianjin Dai, PhD, Hadis Moazami Goudarzi, Gino Lim, Miaolan Xie, Lei Xing, Lewei Zhao
Affiliation: University of Chicago Booth School of Business, Department of Radiation Oncology, Stanford University, Department of Industrial Engineering, University of Houston, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Proton Arc Therapy (PAT) delivers a continuous dose of radiation during gantry rotation. 4Ο is a non-coplanar technique used for advanced proton therapy delivery. This work proposes a hybrid ...
Authors: Hongyu An, Phillip Cuculich, H Michael Gach, Yao Hao, Trevor McKeown, Clifford Robinson, Yuhao Wang, Deshan Yang
Affiliation: Washington University School of Medicine in St. Louis, Washington University School of Medicine, Duke University, Department of Radiation Oncology, Duke University, Washington University in St. Louis, Department of Radiation Oncology, Washington University School of Medicine in St. Louis
Abstract Preview: Purpose: Cardiorespiratory motion management is crucial in stereotactic arrhythmia radiotherapy to define target margins and minimize cardiac toxicity. While respiratory 4DCT (r4DCT) images can infer ...
Authors: Paul L. Carson, Sander Dekker, Stephen Z Pinter, Megan K. Russ
Affiliation: Clinical Imaging Physics Group, Department of Radiology, Duke University Health System, University of Michigan, Cablon Medical B.V., Univ of Michigan, Dept. of Radiology
Abstract Preview: Purpose:
To promote a simplified, inexpensive, but rigorous set of ultrasound QA tests and to evaluate their potential using a Randomly-placed very Hypoechoic Sphere Phantom (RHSP) in comparison to...
Authors: Penghao Gao, Zejun Jiang
Affiliation: Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Artificial Intelligence Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
Abstract Preview: Purpose: Real-time tumor tracking can effectively compensate for the impact of respiratory motion on dose distribution. We propose a patient-specific external-internal correlation model driven by opti...
Authors: Zachary Buchwald, Chih-Wei Chang, Zach Eidex, Richard L.J. Qiu, Mojtaba Safari, Shansong Wang, Xiaofeng Yang, David Yu
Affiliation: Emory University and Winship Cancer Institute, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose: MRI offers excellent soft tissue contrast for diagnosis and treatment but suffers from long acquisition times, causing patient discomfort and motion artifacts. To accelerate MRI, supervised d...
Authors: James R Duncan, Nikhat Fatima Mansoori, Allan Thomas
Affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine
Abstract Preview: Purpose: Collimation during fluoroscopically-guided interventions (FGIs) can not only reduce radiation exposure to patients and personnel but also improve image quality. Nonetheless, there are concern...
Authors: Lily Jo Bertemes, Careesa Billante, Ashley Cetnar, Maximilian Stephen Meineke, Runhe Tan
Affiliation: The Ohio State University James Cancer Hospital, The James Cancer Center, The Ohio State University, The Ohio State University - James Cancer Hospital
Abstract Preview: Purpose: Accessibility is a topic of increasing importance in many fields, and medical physics is no exception. While the traditional educational pathway presents a plethora of challenges for the visu...
Authors: Giacomo Avesani, Matthew D Blackledge, Silvia Bottazzi, Alison Tree, Nina Tunariu
Affiliation: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Institute of Cancer Research, The Royal Marsden NHS Foundation Trust
Abstract Preview: Purpose: To evaluate changes in median apparent diffusion coefficient (ADC) within metastatic oligoprogressing lesions from prostate cancer treated with stereotactic body radiotherapy (SBRT) and compa...
Authors: Julien Forthomme, Carolina Llina Fuentes, Valentin Hamaide, Lucian Hotoiu, Rudi Labarbe, Rasmus Nilsson, Arnaud Pin, Francois Vander Stappen, Erik Traneus
Affiliation: RaySearch Laboratories AB, Ion Beam Applications SA
Abstract Preview: Purpose: Conformal FLASH achieves ultra-high-dose-rate (UHDR) proton therapy (>40 Gy/sec) by scanning a mono-energetic pencil beam through accessories (range shifter, Conformal Energy Modulator, apert...
Authors: Justus Adamson, Mu Chen, Ke Lu, Zhenyu Yang, Fang-Fang Yin, Rihui Zhang, Yaogong Zhang, Haipeng Zhao, Haiming Zhu, Yuchun Zhu
Affiliation: Shanghai Dacheng Medical Technology, Duke University, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, The First People's Hospital of Kunshan
Abstract Preview: Purpose: In filtered back-projection (FBP) reconstruction, conventional filters often reduce noise at the expense of high-frequency details, leading to structural details loss. To address this limitat...
Authors: Morgan A. Daly, David J. Goodenough, Andrew M. Hernandez, John M. Hoffman, Joshua Levy, Michael F. McNitt-Gray, Ali Uneri, Bino Varghese
Affiliation: University of California, George Washington University, David Geffen School of Medicine at UCLA, Johns Hopkins Univ, University of Southern California, The Phantom Laboratory
Abstract Preview: Purpose: Quantitative imaging is affected by CT acquisition and reconstruction conditions, limiting robustness in multi-site or -scanner studies. This work aimed to develop a dataset that will enable ...
Authors: Petr Bruza, Megan Clark, David J. Gladstone, Lesley A Jarvis, Allison Matous, Roman Vasyltsiv, Rongxiao Zhang
Affiliation: Dartmouth Health, Dartmouth College, Thayer School of Engineering, Dartmouth College, Dartmouth Cancer Center, University of Missouri
Abstract Preview: Purpose: On-patient dosimeters assist in clinical decision-making by measuring surface dose, but single-point measurements cannot monitor area-wide distributions and are misleading in high-gradient re...
Authors: Xiaoyu Duan, Xinyu Hu, Runqiu Li, Xiang Li
Affiliation: Dukekunshan University, Medical Physics Graduate Program, Duke Kunshan University
Abstract Preview: Purpose:
Accurate detection of small-sized microcalcifications (ΞΌCalcs) (< 500 Β΅m) is critical for early breast cancer diagnosis, requiring optimal imaging systems and reconstruction algorithms. Ho...
Authors: Evan Calabrese, Scott R. Floyd, Kyle J. Lafata, Zachary J. Reitman, Eugene Vaios, Chunhao Wang, Lana Wang, Deshan Yang, Zhenyu Yang, Jingtong Zhao
Affiliation: Duke University, Department of Radiation Oncology, Duke University, Duke Kunshan University
Abstract Preview: Purpose:
This study proposes a novel neural ordinary differential equation (NODE) framework to distinguish post-SRS radionecrosis from recurrence in brain metastases (BMs). By integrating imaging f...
Authors: Naruomi Akino, Kirsten Lee Boedeker, Ilmar Hein, Dylan Mather, Akira Nishikori, Daniel W Shin
Affiliation: Canon Medical Systems Corporation, Canon Medical Research USA
Abstract Preview: Purpose: To validate the performance a deep learning reconstruction (DLR) algorithm in an anatomical background compared to a uniform phantom background.
Methods: An analytic forward projection mod...
Authors: Wendy Siman, Wei Zhou
Affiliation: University of Colorado Anschutz Medical Campus, School of Medicine
Abstract Preview: Purpose:
To compare the image quality and radiation dose of 3D cone-beam CT modes of a mobile C-arm and an O-arm unit for intraoperative imaging.
Methods:
A 50-Β΅m tungsten wire was imaged at ...
Authors: Zong Fan, Fan Lam, Hua Li, Rita Huan-Ting Peng, Yuan Yang
Affiliation: University of Illinois at Urbana Champaign, University of Illinois at Urbana-Champaign, Washington University School of Medicine, University of Illinois Urbana-Champaign
Abstract Preview: Purpose: Accurate lesion segmentation in MRI is critical for early diagnosis, treatment planning, and monitoring disease progression in various neurological disorders. Cross-site MRI data can alleviat...
Authors: Robert A. Dahl
Affiliation: Mayo Foundation
Abstract Preview: Purpose: To develop tools to simplify/accelerate the quality assurance testing of the Mobetron mobile linear accelerator and increase safety when moving it to different ORβs.
Methods: The Mobet...
Authors: Michael G. Mitch, Csilla I. Szabo-Foster
Affiliation: National Institute of Standards and Technology
Abstract Preview: Purpose: The U.S. air-kerma strength standard for low-dose-rate (LDR) low-energy photon-emitting brachytherapy sources provides measurement traceability for calibrations at the AAPM Accredited Dosimet...
Authors: Indra J. Das, Ahtesham U. Khan, Andrew J. White, Poonam Yadav
Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine
Abstract Preview: Purpose: During intensity modulated radiotherapy (IMRT) planning, low MU segments (< 3 MU) are commonly avoided due to documented dosimetric nonlinearity and poor reproducibility. This work aims to ex...
Authors: Stephen R. Bowen, Chunyan Duan, Daniel S. Hippe, Qiantuo Liu, Jiajie Wang, Shouyi Wang, Faisal Yaseen, Han Zhou
Affiliation: Tongji University, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, Fred Hutchinson Cancer Center, University of Texas at Arlington
Abstract Preview: Purpose: Predicting the effects of the spatial-temporal tumor response to chemoradiation can assist in adjusting radiation dose and support clinical decision-making in radiotherapy. A multi-instance l...
Authors: Yussuf A. Abdelal, Sebastien A. Gros, Luke Layman, Anil Sethi
Affiliation: Stritch School of Medicine, Cardinal Bernardin Cancer Center, Loyola University Chicago, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago
Abstract Preview: Purpose:
End-to-end (E2E) test is a vital QA check of the overall radiotherapy process from simulation imaging to treatment delivery. Although clinical passing criteria are available, guidelines on...
Authors: Edward Robert Criscuolo, Deshan Yang
Affiliation: Duke University, Department of Radiation Oncology, Duke University
Abstract Preview: Purpose:
Deformable registration of 4DCT images has many clinical applications, but current methods are unreliable and can produce dangerous errors. Iterative, parametrized image registration does ...
Authors: Ali Ajdari, Thomas R. Bortfeld, Zhongxing Liao, Mara Schubert, Katrin Teichert
Affiliation: The University of Texas MD Anderson Cancer Center, Department Of Radiation Oncology, Massachusetts General Hospital (MGH), Massachusetts General Hospital & Harvard Medical School, Fraunhofer ITWM
Abstract Preview: Purpose: Radiotherapy (RT) treatment planning often involves solving a multi-criteria optimization (MCO) problem. Conventionally, MCO considers a set of generic (population-wide) dosimetric criteria, ...
Authors: Soren Bentzen, Arezoo Modiri, Zaker Rana, Amit Sawant, Lena Specht, Ivan Vogelius
Affiliation: University of Maryland, University of Maryland in Baltimore, Dept. Of Oncology Copenhagen University Hospital β Rigshospitalet, Maryland University Baltimore, Department of Radiation Oncology, University of Maryland School of Medicine
Abstract Preview: Purpose: There is wide inter-physician radiotherapy planning variability for lymphomas and no systematic way to individualize a plan with respect to patient-specific outcome risks. In response to this...
Authors: Giavanna Luisa Jadick, Patrick J La Riviere, Cailey Riggs
Affiliation: University of Chicago
Abstract Preview: Purpose: We explore the accuracy of physics models for propagation-based x-ray phase-contrast imaging (XPCI) with an eye to future clinical implementation, providing a practical assessment of detectio...
Authors: Yi Fan, Andrew Friberg, Costas Koumenis, Kevin Teo, Ioannis I Verginadis, Ledi Wang, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: Glioblastomas (GBM) are aggressive and lethal malignancies characterized by their highly refractory nature, contributing to a five-year survival rate of approximately 7%. Physically, GBM exhi...
Authors: Mingli Chen, Xuejun Gu, Hao Jiang, Mahdieh Kazemimoghadam, Weiguo Lu, Qingying Wang, Kangning Zhang
Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose:
This work demonstrates how existing software, when creatively adapted, can address a wide range of clinical challenges. By focusing on data exploration and application-specific modificatio...
Authors: Zijia Guo, Viktor Haase, Michael F. McNitt-Gray, Frederic Noo
Affiliation: Siemens Healthineers, University of Utah, David Geffen School of Medicine at UCLA
Abstract Preview: Purpose: The attenuation values in CT hold strong potential for disease diagnosis. However, they lack reliability, which has limited their use to clinical trials where variability can be controlled. S...
Authors: Victoria Susan Ainsworth, Wilfred F. Ngwa, Erno Sajo
Affiliation: University of Massachusetts Lowell, Johns Hopkins University
Abstract Preview: Purpose: In nanoparticle-enhanced radiotherapy, the dose enhancement is function of the particle size. At therapeutic concentrations, the number density of nanoparticles gives rise to a high rate of i...
Authors: Laura I. Cervino, Wendy B. Harris, Paulo Quintero, Hao Zhang
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: To evaluate the impact of the prediction uncertainty from CBCT-based synthetic CT (sCT) generation in abdominal adaptive radiotherapy.
Methods: CT and CBCT images from 65 abdominal pat...
Authors: Naruomi Akino, Kirsten Lee Boedeker, Ilmar Hein, Akira Nishikori, Daniel W Shin
Affiliation: Canon Medical Systems Corporation, Canon Medical Research USA
Abstract Preview: Purpose: To validate a simulation tool using physics-based image quality metrics in both phantom and patient data, and to assess the low contrast detectability (LCD) of Super Resolution-Deep Learning ...