Authors: Brett Bocian, Nesrin Dogan, John C. Ford, Alan Pollack, Ryder Marshall Schmidt, Junwei Shi, Jorge D Vega
Affiliation: University of Miami, University of Miami Sylvester Comprehensive Cancer Center
Abstract Preview: Purpose: X-ray fluorescence computed tomography (XFCT) is an emerging molecular imaging modality gaining attention in cancer theranostics with high-Z metal nanoparticles (MNPs). While XFCT has been de...
Authors: Sean L. Berry, Hsiang-Chi Kuo, Seng Boh Gary Lim, Ingrid Valencia Lozano, Laszlo Voros
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose:
To quantify the impact of target degradation on 6FFF beam output by analyzing the output trends and adjustment frequencies at our clinic on a flattening filter-free (6FFF) and a flattened ...
Authors: Mitya M. Barreto, Nichole A. Harris
Affiliation: Department of Radiology, University Hospitals Cleveland Medical Center
Abstract Preview: Purpose: To evaluate dosimeter dependence of measured AGD, and to develop a dosimeter independent method for evaluating the AGD, for CEDM exposures.
Methods: Three solid-state dosimeters (Raysafe-X...
Authors: Haonian Gong, Yue Gu, Meiqi Liu, Zihao Liu, Hsiao-Ming Lu, Yuxiang Wang, Yidong Yang, Cheng Zheng
Affiliation: Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China, University of Science and Technology of China
Abstract Preview: Purpose:
Proton radiotherapy in preclinical small animals requires specific dose engine due to its low energy and small irradiation volume. This study is to develop a GPU-based Monte Carlo dose eng...
Authors: Laura Bennett, Wesley S. Culberson, Albert Du, Kevin J. Erhart, Ryan T. Flynn, Ryan Gardner, Alonso N. Gutierrez, Patrick M Hill, Daniel E. Hyer, Eric Jensen, Kaustubh A. Patwardhan, Blake R. Smith, Nhan Vu, Karsten K. Wake
Affiliation: University of Wisconsin, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Miami Cancer Institute, Baptist Health South Florida, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Ion Beam Applications (IBA), University of Iowa, Iowa Health Care, .decimal
Abstract Preview: Purpose: To develop and experimentally validate a novel Monte Carlo (MC) framework designed to enable calculation-based quality assurance (QA) for collimated intensity modulated proton therapy treatme...
Authors: Sung Woon Choi, Dong Wook Kim, Jin Sung Kim, Na Hye Kwon, Paulo Jorge Ribeiro Da Fonte
Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Coimbra Institute of Engineering, Polytechnic University of Coimbra
Abstract Preview: Purpose: In hadrontherapy, such as proton and carbon ion therapy, it is desirable, for quality assurance reasons, to have an online beam energy measurement independent from the machine parameters. Sin...
Authors: Andrew Clarke Grice, Evan A. Silverstein
Affiliation: Sutter Medical Foundation, Sutter Health
Abstract Preview: Purpose: To implement an efficient and effective process for Electron beam matching between 5 Varian True Beams (TB).
Methods: We adapted the Varian installation/acceptance process for TBs, whereby...
Authors: Larry A. DeWerd, Sean Jollota, Karen Rex Pius Vincent
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison
Abstract Preview: Purpose: Absolute measurements, often used to establish primary standards, offer lower measurement uncertainty. For 192Ir high-dose-rate (HDR) brachytherapy, the interim primary standard for air-kerma...
Authors: Amir Abdollahi, Celine Karle, Michele M. Kim, Constantinos Koumenis, Andrea Mairani, Erato Stylianou Markidou
Affiliation: Heidelberg Ion-Beam Therapy Center - Department of Radiation Oncology, German Cancer Research Centre(DKFZ), University of Pennsylvania, Physics Dep. University of Cyprus
Abstract Preview: Purpose: The aim is to compare FLASH dose-rate RT generated with protons and carbon (HIT) and compare to protons (UPenn) to provide evidence for equipotency of FLASH vs. standard RT to tumor growth co...
Authors: Harsh Arya, Yan Chang, Yujie Chi, Varghese Anto Chirayath, Joshua Rajan, Pan Zui
Affiliation: University of Texas at Arlington, Department of Physics, University of Texas at Arlington
Abstract Preview: Purpose: In targeted alpha therapy (TAT), absorbed dose rates can vary significantly spatially and temporally, impacting therapeutic efficacy as well as carcinogenic potential. This study reports the ...
Authors: Ross I. Berbeco, Vera Birrer, Raphael Bruegger, Pablo Corral Arroyo, Roshanak Etemadpour, Dianne M. Ferguson, Rony Fueglistaller, Thomas C. Harris, Yue-Houng Hu, Matthew W. Jacobson, Mathias Lehmann, Marios Myronakis
Affiliation: Medical Physics Department, Medical School, University of Thessaly, Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, Dana Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Brigham and Womenâs Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women's Hospital, Varian Imaging Laboratory
Abstract Preview: Purpose:
Dual-layer kV imager (DLI) architecture enables the capability for single-shot dual-energy (DE) intrafraction imaging. As noise from individual DLI layers are primarily uncorrelated, simpl...
Authors: Anna Becker, Tomislav Bokulic, Mauro Carrara, Krzysztof Chelminski, Larry A. DeWerd, Alexis Dimitriadis, Benjamin Kellogg, Malcolm R. McEwen, Zakithi L.M Msimang, Mark J. Rivard, Thorsten Sander, Thorsten Schneider, Jamema Swamidas, Egor Titovich, Paula Toroi, Carlos E. de Almeida, Jacco de Pooter, Liset de la Fuente Rosales, Deborah G. van der Merwe
Affiliation: Radiation and Nuclear Safety Authority, University of Zagreb, National Physical Laboratory, IAEA, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Rio de Janeiro State University, Dosimetry Laboratory, Dosimetry and Medical Radiation Physics Section, Division of Human Health, International Atomic Energy Agency, Physikalisch-Technische Bundesanstalt, National Metrology Institute, University of the Witwatersrand, Dosimetry and Medical Radiation Physics Section, Division of Human Health, International Atomic Energy Agency, National Research Council, Warren Alpert Medical School of Brown University
Abstract Preview: Purpose: The recently published IAEA-TRS-492 international code of practice (CoP) aims at improving traceability, accuracy, and consistency in Brachytherapy Dosimetry. To assess current approaches to ...
Authors: Javier Chiasson, Dominique Guillet, Arthur Lalonde, Karim Zerouali
Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal
Abstract Preview: Purpose:
To validate a Monte Carlo (MC) model of a Ultra-High dose rate (UHDR) electron beam using a prototype flashdiamond (fD) detector coupled to an electrostatically shielded beam current trans...
Authors: Shaojie Chang, Thomas A. Foley, Hao Gong, Emily Koons, Shuai Leng, Cynthia H. McCollough, Eric E. Williamson
Affiliation: Mayo Clinic
Abstract Preview: Purpose: To enhance coronary CT angiography (cCTA) capabilities on conventional energy integrating detector CT (EID-CT) using artificial intelligence (AI). The AI framework incorporates high-resolutio...
Authors: Philip Cutter, Mark D'Souza, Arman Sarfehnia
Affiliation: Toronto Metropolitan University, Sunnybrook Health Sciences Centre, Sunnybrook Health Science Center
Abstract Preview: Purpose: Water calorimetry (WC) serves as an important standard for measuring absorbed dose to water, an essential metric in radiation therapy. WC directly and absolutely quantifies energy deposition ...
Authors: Maria F. Chan, Seng Boh Gary Lim, Shih-Chi Lin, Dustin W. Lynch, Usman Mahmood, Jeonghoon Park
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: To explore the feasibility of using GafChromic LD-V1 film for annual imaging dose assessment across kV radiography, fluoroscopy, and cone beam computed tomography (CBCT) imaging protocols, as...
Authors: Paul Boisseau, Eric S. Diffenderfer, Andrew Friberg, Wenbo Gu, Matthew Nichols, Kan Ota, Xiaokun Teng, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology, University of Pennsylvania, Pyramid Technical Consultants, Inc., University of Pennsylvania
Abstract Preview: Purpose: Traditional quality assurance procedures for proton pencil beam energies involve water tank setups or multiple solid water phantoms and are time-consuming. This study demonstrates that an inn...
Authors: Luke Connell, Stephen F. Kry, Malcolm R. McEwen, Bryan R. Muir, James Renaud, Emil Schueler, Hayden Scott, Paige A. Taylor
Affiliation: National Research Council, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: To demonstrate the capability of a robust calorimeter to accurately determine the absorbed dose delivered by an electron FLASH beamline.
Methods: Electron FLASH beams of 6 MeV and 9 Me...
Authors: Ronald C Chen, Hao Gao, Nicolas Gerard, Harold Li, Yuting Lin, Jarrick Nys, Jufri Setianegara, Mark Szczepanski, Aoxiang Wang
Affiliation: 4Physikalisch-Technische WerkstÀtten (PTW), Department of Biomedical Engineering, Huazhong University of Science and Technology, Ion Beam Applications (IBA), Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Modern synchrocyclotrons can produce magnetically-scanned protons at ultra-high dose-rates (FLASH). However, their pulsed nature leads to high doses-per-pulse (DPP) which can cause non-neglig...
Authors: Serdar Charyyev, Kaan Dere, Edgar Gelover, Mohammad Khurram Khan, Liyong Lin, Mark McDonald, Cristina Oancea, Alexander Stanforth, Sibo Tian, Suk Whan (Paul) Yoon, Mingyao Zhu
Affiliation: Department of Radiation Oncology, Stanford University, Stanford University, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Advacam
Abstract Preview: Purpose: The conventional implementation of proton spatially fractionated radiotherapy (SFRT) utilizes physical collimators with apertures to generate minibeams, creating alternating regions of high-d...
Authors: Mohamad Ahmad Alissa, Carson Brame, Damian Czarnecki, Olivier Evrard, Charbel A. Habib, Jeff Hildreth, Andy Murray, Andreas Schönfeld, Ann-Britt Schönfeld, David Towle, Gerd Wessing
Affiliation: CDT-West - Centrum fĂŒr Diagnostik und Therapie, Radiologie Vechta, Technische Hochschule Mittelhessen, MyMichigan Health, Sun Nuclear Corp., Mirion Technologies
Abstract Preview: Purpose: To characterize the performance of novel shielded and unshielded silicon diode detectors in relative photon and electron beam dosimetry.
Methods: The novel shielded and unshielded sili...
Authors: Dominique Guillet, Arthur Lalonde, Bryan R. Muir, James Renaud, Karim Zerouali
Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal, National Research Council
Abstract Preview: Purpose:
To evaluate the dose rate dependence, beam quality dependence, and short-term stability of a novel flashDiamond (fD) prototype detector for conventional and ultra-high dose rate (UHDR) bea...
Authors: Amar K. Basavatia, Lee C. Goddard, Rachel Grimm, Wolfgang A. Tomé
Affiliation: Montefiore Medical Center
Abstract Preview: Purpose: To characterize the âMyOSL Chipâ OSLD system for clinical use and compare the response of multiple readers to allow for utilization in a multi-clinic environment.
Methods: Dose calibration...
Authors: Gulakhshan M Hamad, Sina Mossahebi, Yannick P. Poirier, Amit Sawant
Affiliation: University of Maryland School of Medicine, Maryland University Baltimore
Abstract Preview: Purpose:
The combination of ultra-high dose rate (UHDR) proton therapy, known for normal tissue sparing, with spatially-fractionated radiotherapy (SFRT), promising enhanced tumor control and tissue...
Authors: Maria Jose Almada, Carlos Bohorquez, Maximiliano Musso, Rosa Petit, Carlos Daniel Venencia, Lucy D. Wolfsberger
Affiliation: LAP, Instituto Zunino - Fundacion Marie Curie
Abstract Preview: Purpose:
PSQA is crucial in maintaining patient safety, typically depending on dosimetric measurements. However, advancements in computational technology have highlighted the growing significance o...
Authors: Ahmet S. Ayan, Austin M. Faught, Eunsin Lee, Julia Pakela
Affiliation: Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Ohio State University, The Ohio State University
Abstract Preview: Purpose: To present commissioning of a fixed beamline ultra-high dose rate proton pencil beam scanning system, the worldâs first multi-room Varian ProBeam360â°
Methods: The fixed beamline pencil bea...
Authors: Michalis Aristophanous, Steven Blum, Laura I. Cervino, Antonio L. Damato, Karen Episcopia, Chi Huang, Shih-Chi Lin, Michelle K. Savacool
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Varian Ethos (Varian Medical Systems, Palo Alto, CA) is a 6 MV flattening-filter-free (FFF) only machine, posing a challenge in creating homogeneous dose distributions when using manual 3D-CR...
Authors: Maria F. Chan, Indra J. Das, Xiuxiu He, Seng Boh Gary Lim, Jeonghoon Park, Yunjie Yang
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: There is a need for accurate and flexible in-vivo dosimetry systems, particularly for special procedures. Effective dosimetry is crucial for dose verification and maintaining records. A new r...
Authors: Gueorgui Gueorguiev, Katia Sergieva, Filip Simeonov, Tsvetelina Todorova, Bozhidar Vladimirov
Affiliation: National Centre of Radiobiology and Radiation Protection, Queen Giovanna University Hospital
Abstract Preview: Purpose: Dosimetry audit is an essential tool enhancing confidence in the accuracy of treatment delivery and in prevention of radiation treatment incidents. Current work depicts how novel nationwide r...
Authors: Chang Heon Choi, Yoonsuk Huh, Jin Jegal, Seonghee Kang, Jung-in Kim, Inbum Lee, Hyojun Park
Affiliation: Department of Radiation Oncology, Seoul National University Hospital
Abstract Preview: Purpose: This study evaluates SpekPy, a Python-based tool for modeling kilovoltage (kV) x-ray spectra, by comparing its calculated energy spectra, half-value layer (HVL), and air kerma with experiment...
Authors: Paul Deak, Yang Li, Mark Pankuch, Yanling Qu, Maggie Stauffer, Hazel Wang
Affiliation: Northwestern Medicine Proton Center, GE, Northwestern Medicine
Abstract Preview: Purpose: The objective is to evaluate Relative Stopping Power(RSP) accuracy of ultra-fast switching KV Dual-Energy CT(DECT) in animal tissue and compare it to the RSP converted from Single Energy CT(S...
Authors: Mostafa Cham, Matthias K Gobbert, Zhuoran Jiang, Sina Mossahebi, Ruth Obe, Stephen W. Peterson, Jerimy C. Polf, Lei Ren, Ehsan Shakeri, Vijay Raj Sharma
Affiliation: University of Maryland School of Medicine, UMBC, University of Maryland Baltimore County, University of Maryland, Baltimore County, Stanford University, University of Maryland, School of Medine, Department of Physics, University of Cape Town, M3D, Inc, Department of Infomation Systems, UMBC
Abstract Preview: Purpose: Compton camera (CC)-based prompt gamma imaging (PGI) offers real-time proton range verification. However, its limited-angle measurements cause severe distortions in PGI, affecting its clinica...
Authors: Peter Balter, Andres V Cibrian, Song Gao
Affiliation: The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: The purpose of this study is to demonstrate a means of detecting misaligned jaw face angles on the Varian TrueBeam based on a beam symmetry metric for electron beam profiles.
Methods: Duri...
Authors: Clifford Ghee Ann Chua, Calvin Wei Yang Koh, Kah Seng Lew, Zubin Master, Sung Yong Park, Hong Qi Tan, Andrew Wibawa
Affiliation: National Cancer Centre Singapore
Abstract Preview: Purpose: To investigate the impact of spot position deviation on reference dosimetry measurements using different delivery patterns and to determine the optimal delivery pattern for reference dosimetr...
Authors: Md. Jobairul Islam
Affiliation: Department of Radiation Oncology, Labaid Cancer Hospital and Super Speciality Centre
Abstract Preview: Purpose: Electron radiotherapy is an effective treatment for superficial tumors but requires field-shaping devices like electron applicators, which are labor-intensive to produce. This study aimed to ...
Authors: Wesley S. Culberson, Ryan Gardner, Patrick M Hill, Mark Pankuch, Karsten K. Wake
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Northwestern Medicine Proton Center
Abstract Preview: Purpose: To assess the dosimetric capabilities of Sun Nuclear (Melbourne, FL) EDGE Diode Detectorsâą for measurements in the plateau region of pencil beam scanning (PBS) fields. Many clinical dosimeter...
Authors: Amar K. Basavatia, Sandeepan Ganguly, Lee C. Goddard, Wolfgang A. Tomé
Affiliation: Montefiore Medical Center
Abstract Preview: Purpose: To investigate the dosimetric impact of WGTG51-e Report 385, recently updated CoP for clinical electron beams. This study uses a chamber specific effective point of measurement (EPOM) shift t...
Authors: Michael Dingfelder, Homeira Faridnejad
Affiliation: East Carolina University, Department of Physics, East Carolina University
Abstract Preview: Purpose: To use Gafchromic film for measurement of the dose delivered by low-energy (2-4 MeV) protons to living cells.
Methods: Five different types of Gafchromic films were tested for dosimetry un...
Authors: Winter Green, Yao Hao, Nels C. Knutson, Matthew C. Schmidt, Xiandong Zhao
Affiliation: Washington University School of Medicine in St. Louis, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, WashU Medicine
Abstract Preview: Purpose: Beam profile flatness is crucial for both photon and proton radiotherapy systems. This work investigated the dosimetry impact of beam flatness on a clinical synchrocyclotron proton system.
Authors: Christoph Bert, Leon BrĂŒckner, Luitpold Distel, Julian Freier, Peter Hommelhoff, Bastian Löhrl
Affiliation: Department of Radiation Oncology, Uniklinikum Erlangen, Friedrich-Alexander-UniversitĂ€t Erlangen-NĂŒrnberg, Department Physik, Friedrich-Alexander UniversitĂ€t Erlangen-NĂŒrnberg
Abstract Preview: Purpose: Low energy electron (LEE) bunches in the kilo electronvolt (keV) range are thought to have a high relative biological effectiveness (RBE). To investigate this, it is necessary to establish re...
Authors: Daniel A. Alexander, Jeffrey D. Bradley, Steven J. Feigenberg, Cole Friedes, Casey Hollawell, William Levin, Maksym Sharma, Boon-Keng Kevin Teo, Ying Xiao, Nikhil Yegya-Raman, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology and Applied Sciences, Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: To investigate lung function changes following definitive chemoradiation dose using CT-derived measurements in patients with locally advanced NSCLC at 6-months post-treatment compared to pre-...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Luuk J Oostveen, Elsa Bifano Pimenta, Ioannis Sechopoulos, Alessandra Tomal
Affiliation: Radboud University Medical Center, University of SĂŁo Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de FĂsica Gleb Wataghin
Abstract Preview: Purpose: This study aimed to evaluate the precision and accuracy of volume measurements for solid nodules (SNs) and ground-glass opacities (GGOs) in lung images acquired using energy-integrating CT (E...
Authors: Sabrina Campelo, Sandun Y. Jayarathna, Adam D. Melancon, Paige L. Nitsch, Christopher Ryan Peeler, Julianne M. Pollard-Larkin, Ramaswamy Sadagopan, Xiaochun Wang, George Zhao
Affiliation: The University of Texas MD Anderson Cancer Center
Abstract Preview: Purpose: Development of an in-house analytical simulation for streamlining photon counting detector (PCD) system protocols through measuring transmitted photon energy spectra through a Hafnium (Hf)-lo...
Authors: Yunzhi Ma, Ling Zhuang
Affiliation: Northwestern Medicine
Abstract Preview: Purpose: Multiple layers of brass mesh bolus (RPD, Inc., Albertville, MN) may be needed to provide better body conformity and sufficient dose build up on patient surface during electron treatment. Thi...
Authors: Jeff Boob, Jaydev K. Dave, Tim Minch, Bhavyata Tanna
Affiliation: Dr. Ronald E. McNair Academic High School, Mayo Clinic, CurveBeam AI
Abstract Preview: Purpose: To compute effective doses associated with imaging of the extremities with a HiRise (CurveBeam AI, Hatfield, PA) cone-beam CBCT scanner specifically designed for weight-bearing imaging of the...
Authors: Chen-Ju Feng, Shih-Ming Hsu, Chin-Hsiung Lin, Shih-Yong Luo, Shao-Chun Tseng, Chin-Hui Wu, Ya-Ru Yang
Affiliation: National Yang Ming Chiao Tung University, Koo Foundation Sun Yat-Sen Cancer Center, Tzu-Chi University, NanoRay Biotech Co., Ltd
Abstract Preview: Purpose: The range of auger electrons in water is 2~500 nm, and its linear energy transfer reaches 26 keV/ÎŒm. This study investigated the feasibility of the auger electron radiation therapy.
Method...
Authors: Grace Hutchinson, Daniel E. Hyer, Samuel D. Rusu, Blake R. Smith, Joel J. St-Aubin
Affiliation: Iowa Health Care, University of Iowa
Abstract Preview: Purpose: To assess the feasibility and consistency of the Sun Nuclear Corporation (SNC) MR conditional Quad Wedge, as an accessory to the IC Profiler-MR, and to evaluate beam output and energy in the ...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Renan Felix dos Santos, Gustavo Freire Pereira da Silva, Alessandra Tomal
Affiliation: University of SĂŁo Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de FĂsica Gleb Wataghin
Abstract Preview: Purpose: Evaluate the feasibility of a bench-top PCCT using Geant4 Monte Carlo simulations. The study applied the Geant4 framework on determining the electronic density of materials as a function of C...
Authors: Yoshihiko Hoshino, Kenji Hotta, Taeko Matsuura, Ai Nakaoka, Hidenobu Tachibana
Affiliation: Hokkaido University, Department of Radiology, Gunma University Hospital, Radiation Safety and Quality Assurance Division, National Cancer Center Hospital East
Abstract Preview: Purpose: Gel dosimeters enable three-dimensional dose measurements, but no reports have evaluated the fundamental performance of VIPER-type gel dosimeters in proton beam measurements. Therefore, we ev...
Authors: Robert Berry, John Buatti, Nathan Burger, Ryan T. Flynn, Greg Johns, Maksim Kravchenko, Sergey Kutsaev, Yen-Po Lee, Marcos Ruelas, Joel J. St-Aubin, Timothy J. Waldron
Affiliation: RadiaBeam Technologies, University of Iowa
Abstract Preview: Purpose: To report the factory acceptance tests of a preclinical linear accelerator, the FLEX-9 electron FLASH linac from RadiaBeam Technologies.
Methods: The FLEX-9 FLASH electron linac is designe...
Authors: Ramesh Boggula, Jay W. Burmeister
Affiliation: Wayne State University, Karmanos Cancer Center, Gershenson ROC, Wayne State University School of Medicine
Abstract Preview: Purpose: This study evaluated the performance of a hybrid Compton camera for real-time imaging during the administration of Lu-177-based radiopharmaceuticals, including Pluvicto and Lutathera. The aim...
Authors: Fitria P Krisna, Mardon Limena, Supriyanto Ardjo Pawiro, Jhon H Saragih, Wahyu E. Wibowo, Poonam Yadav, Ummu M Zahro
Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Radiation Oncology Dr. Cipto Mangunkusumo National Central Public Hospital, Department of Physics, Mathematics and Natural Sciences, University of Indonesia, Department of Radiotherapy, Mandaya Hospital, Department of Radiation Oncology, Mitra Keluarga Kenjeran Hospital, Department of Radiotherapy, Mandaya Royal Hospital, Radiation Oncology, Santosa Hospital
Abstract Preview: Purpose: To perform depth dose characteristics of High Dose Electron Beam and utility of various commercially available detectors.
Methods: The measurements were performed using an Elekta Versa HD ...
Authors: Davide Brivio, Lia Carroll, Juliane Daartz, Jan PO Schuemann, Piotr Zygmanski
Affiliation: Massachusetts General Hospital, Department of Radiation Oncology, Brigham and Womenâs Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: We employ High-Energy Current (HEC) detectors for real-time monitoring of proton beams at conventional to FLASH dose rates. This would help overcome the need for fast and accurate dosimeters ...
Authors: B. Gino Fallone, Alireza Gazor, Andrei D. Ghila, Gawon Han, Patricia A. K. Oliver, Michael W. Reynolds, Keith D. Wachowicz, Tania Rosalia Wood, Shima Y. Tari, Eugene Yip
Affiliation: Medical Physics Division, Department of Oncology, University of Alberta, Nova Scotia Health, Dept. of Medical Physics and Dalhousie University, Dept. of Physics and Atmospheric Science, Dept. of Radiation Oncology, Dept. of Medical Physics, Cross Cancer Institute and Dept. of Oncology, University of Alberta; MagnetTx Oncology Solutions, www.magnetTX.com, Department of Medical Physics, Arthur J. E. Child Comprehensive Cancer Centre, Dept. of Medical Physics, Cross Cancer Institute and Dept. of Oncology, University of Alberta, Department of Medical Physics, BC Cancer, Medical Physics Division, Department of Oncology, University of Alberta and Department of Medical Physics, Cross Cancer Institute
Abstract Preview: Purpose: To develop and validate a high-fidelity Monte-Carlo (MC) model of a 0.5T bi-planar Linac-MR in TOPAS, focusing on accurate Multileaf Collimator (MLC) modelling and positioning for open apertu...
Authors: Salman M. Arnab, Yves Chevalier, Samuel Gagné, Adrian F. Howansky, Luc LaperriÚre, Xiangyi Wu, Wei Zhao
Affiliation: Stony Brook Medicine, Analogic Canada
Abstract Preview: Purpose: A direct-indirect dual-layer flat-panel-detector (DI-DLFPD) is under development for patient motion artifact-free contrast-enhanced digital mammography (CEDM). DI-DLFPD comprises a direct fro...
Authors: Michael Ashenafi, Nicholas Becerra Espinosa, Mario Ramos Gallardo, Matthew Pacella, Sean M. Tanny
Affiliation: Department of Radiation Oncology, University of Rochester
Abstract Preview: Purpose: A new multileaf collimator (MLC) model has been introduced in Varian Eclipse v18.0, with the treatment planning system (TPS) explicitly modeling the leaf end effects. The vendor recommends a ...
Authors: Wesley S. Culberson, Larry A. DeWerd, Ahtesham Ullah Khan, Zachary James Welchel
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison
Abstract Preview: Purpose: Flattening filter free (FFF) linac beams exhibit a centrally peaked beam profile due to the forward-directed bremsstrahlung production from MeV electrons, leading to volume averaging effects ...
Authors: Jacqueline M. Andreozzi, Savannah Decker, Diego Hernandez, Iman R. Washington
Affiliation: UC San Diego, Department of Radiation Oncology, Moffitt Cancer Center, University of South Florida, Moffitt Cancer Center
Abstract Preview: Purpose: Recent advances in external beam radiation therapy have begun to explore the utility of Cherenkov radiation imaging as a beam delivery visualization tool. When sheet bolus is used during trea...
Authors: Mohammadreza Ay, Nahal Daneshgar, Nima Kasraie, Abbas Monsef, Zeinab Peymani, Hadi Rezaei, Peyman Sheikhzadeh
Affiliation: University of Minnesota Medical School, Radiation Oncology, Department of Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Shiraz University of Medical Sciences, Department of Medical Physics, Tehran University of Medical Sciences, Department of Medical Physics and Biomedical Engineering, UT Southwestern Medical Center, Imam Khomeini Hospital Complex,Tehran University of Medical Sciences
Abstract Preview: Purpose:
This study aims to design and simulate an innovative pediatric-dedicated SPECT scanner optimized for childrenâs unique anatomical and safety needs by enhancing sensitivity in data acquisit...
Authors: Alexei V. Chvetsov, Sunan Cui, Sunyoung Jang, Robert D. Stewart
Affiliation: University of Washington and Fred Hutchinson Cancer Center, Penn State College of Medicine, University of Washington
Abstract Preview: Purpose: To evaluate spatial variation of relative biological effectiveness (RBE) in COMS (Collaborative Ocular Melanoma Study) eye plaques with low energy 125I and 103Pd photon sources as a function ...
Authors: Kenny Guida, Hongyu Jiang, Harold Li, Hem Bahadur Moktan Tamang
Affiliation: University of Nebraska Medical Center, Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Varian Eclipse v18.0 introduced Enhanced Leaf Model (ELM) of MLC, which provides better dose calculation accuracy than original DLG-based MLC model. The leaf-gap (LG) parameter for ELM repres...
Authors: Ruiming Chen Edmondson, Darwin Abraham Garcia, James A. Kavanaugh, Joseph John Lucido
Affiliation: Mayo Clinic
Abstract Preview: Purpose: Characterize the dose response and reproducibility of a low-dose film for 6 MV photon beam and assess the filmâs energy dependence between kV and MV energies.
Methods: A single 8âx10â LD-V...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Luuk J Oostveen, Elsa Bifano Pimenta, Ioannis Sechopoulos, Alessandra Tomal
Affiliation: Radboud University Medical Center, University of SĂŁo Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de FĂsica Gleb Wataghin
Abstract Preview: Purpose: The study evaluated the accuracy and precision of lung nodule volume measurements, specifically solid nodules (SNs) and ground-glass opacities (GGOs) in different imaging settings.
Methods...
Authors: Giavanna Luisa Jadick, Patrick J La Riviere
Affiliation: University of Chicago
Abstract Preview: Purpose: We assess two multi-measurement acquisition schemes for material decomposition with x-ray phase-contrast imaging (XPCI); demonstrating for the first time that multi-distance imaging can match...
Authors: Michael G. Mitch, Csilla I. Szabo-Foster
Affiliation: National Institute of Standards and Technology
Abstract Preview: Purpose: The U.S. air-kerma strength standard for low-dose-rate (LDR) low-energy photon-emitting brachytherapy sources provides measurement traceability for calibrations at the AAPM Accredited Dosimet...
Authors: Indra J. Das, Ahtesham U. Khan, Andrew J. White, Poonam Yadav
Affiliation: Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine
Abstract Preview: Purpose: During intensity modulated radiotherapy (IMRT) planning, low MU segments (< 3 MU) are commonly avoided due to documented dosimetric nonlinearity and poor reproducibility. This work aims to ex...
Authors: Michael M Folkerts, Miriam Krieger, Pierre Lansonneur, Gerard Paquet, Petar Penchev, Christoph Schuy, Yuri Simeonov, Uli Weber, Klemens Zink
Affiliation: GSI Helmholtzzentrum fuer Schwerionenforschung, Institute of Medical Physics and Radiation Protection (IMPS), University of Applied Sciences, Varian Medical Systems
Abstract Preview: Purpose:
Ultra-high dose-rate proton irradiation may spare the healthy tissue (FLASH-effect). The 3D-range-modulator (3D-RM) method reduces the treatment time compared to conventional IMPT and can ...
Authors: Mercy Iyabode Akerele, Yuni K. Dewaraja, Richard Laforest, Justin K. Mikell, Wendy Siman, Allan Thomas, Daniel Thorek
Affiliation: University of Michigan, Washington University School of Medicine in St. Louis, Washington University School of Medicine, University of Colorado Anschutz Medical Campus, School of Medicine, Washington University in St. Louis, Mallinckrodt Institute of Radiology, Washington University School of Medicine
Abstract Preview: Purpose: Post-therapy quantitative 90Y SPECT and PET measurements show ~25% lower activity than vendor-reported values for glass microspheres. We hypothesize this discrepancy is due to bremsstrahlung ...
Authors: Jason Ellsworth, Mark Mishra, Jason K Molitoris, Lei Ren, Dario B. Rodrigues, Paul Turner, Graeme Woodworth
Affiliation: University of Maryland School of Medicine, Department of Neurosurgery, University of Maryland School of Medicine, University of Maryland, Department of Radiation Oncology, University of Maryland School of Medicine, Pyrexar Medical
Abstract Preview: Purpose: Hyperthermia therapy (HT) involves increasing tumor temperatures to 40-44°C and is a potent radio- and chemosensitizer for treating solid tumors. Current clinical strategies to heat deep-seat...
Authors: Chih-Wei Chang, Junbo Peng, Richard L.J. Qiu, Justin Roper, Xiangyang Tang, Tonghe Wang, Huiqiao Xie, Xiaofeng Yang, David Yu
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Emory Univ, Emory University, Memorial Sloan Kettering Cancer Center, Department of Radiation Oncology and Winship Cancer Institute, Emory University
Abstract Preview: Purpose: Limited-angle dual-energy (DE) cone-beam CT (CBCT) is considered a promising solution to achieve fast and low-dose DE imaging on current CBCT scanners without hardware modification. However, ...
Authors: Sebastien A. Gros, Hyejoo Kang, Andrew Keeler, Luke Layman, Jason Patrick Luce, Ha Nguyen, John C. Roeske
Affiliation: Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago
Abstract Preview: Purpose:
This study aims to optimize virtual monoenergetic (VM) images obtained from dual-energy (DE) cone-beam computer tomography (CBCT) protocols for Image-Guided Radiation Therapy (IGRT). The o...
Authors: Frank F. Dong, Megan C. Jacobsen, Ke Li, Xinming Liu, John Rong
Affiliation: UT MD Anderson Cancer Center
Abstract Preview: Purpose: We aimed to understand the physical performance of a CdTe PCD-based detector system within a whole-body PCD-CT scanner, with the goal of optimizing its clinical application. Instead of relyin...
Authors: Mohammed Alzaabi, Abderaouf Behouch, Nabil Maalej, Aamir Raja, Briya Tariq
Affiliation: Khalifa University
Abstract Preview: Purpose: Spectral Photon Counting CT (SPCCT) has emerged as a transformative technology in CT imaging capable of producing images from distinct energy windows, allowing improved material characterizat...
Authors: Carina Gassner, Guyue Hu, Thomas Kröncke, Christopher Kurz, Guillaume Landry, Katharina Niepel, Katia Parodi, Franka Risch, Florian Schwarz
Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Diagnostic and Interventional Radiology, University Hospital Augsburg, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t (LMU) MĂŒnchen, Department of Medical Physics, Ludwig-Maximilians-UniversitĂ€t MĂŒnchen (LMU Munich)
Abstract Preview: Purpose: To evaluate the performance of a clinical photon-counting CT (PCCT) scanner in terms of proton relative stopping power (RSP) estimation using PCCT data and to compare the impact of different ...
Authors: Saad Bin Saeed Ahmed, Marcos Feijoo, Wazir Muhammad, Charles Shang, Naseem Ud Din
Affiliation: South Florida Proton Therapy Institute, Miami Cancer Institute, Blue Physics LLC, Florida Atlantic University
Abstract Preview: Purpose: This study introduces a novel approach for patient-specific quality assurance in proton beam therapy, utilizing new plastic scintillator detectors with high temporal resolutions to create det...
Authors: David Alcorta, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, Mark Oldham, Victoria J. P. Radosova
Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center
Abstract Preview: Purpose: This study attempts to simulate the activation of targeted photodynamic molecules using visible laser light and characterize the direct Reactive Oxygen Species (ROS) generated by Cherenkov an...
Authors: Jonthomas Michael Box, Isaac B. Rutel
Affiliation: University of Oklahoma Health Sciences Center
Abstract Preview: Purpose: This study assesses the feasibility of using speckle images and a modified phase retrieval algorithm to reconstruct the point spread function (PSF) of a diagnostic x-ray system. While speckle...
Authors: Izabella L. Barreto, Benjamin Taylor Heggie, Stephanie M. Leon
Affiliation: University of Florida College of Medicine, University of Florida
Abstract Preview: Purpose: Filament deposition modeling (FDM) 3D printers may utilize proprietary calibration methods inadequate for medical imaging. Proper techniques are necessary to achieve imaging uniformity standa...
Authors: Wesley S. Culberson, Ryan Gardner, John Thomas Stasko
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin
Abstract Preview: Purpose: X-ray tube voltage is a critical parameter in influencing an X-ray tubeâs beam quality. The endpoint tube potential, the potential difference between the X-ray tubeâs cathode and anode, is pa...
Authors: Guang-Pei Chen, Renae Conlin, Juan A. Garcia-Alvarez, Kirk Morris, Haidy G. Nasief, Eenas A. Omari, Eric S. Paulson
Affiliation: Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: Cumulative dose limits make replacing and calibrating Metal Oxide Semiconductor Field Effect dosimeters (MOSFET-d) used for in-vivo dosimetry a common clinical task. Calibration protocols for...
Authors: Huixiao Chen, Zhe (Jay) Chen, MinYoung Lee, Sameer Taneja
Affiliation: Yale School of Medicine, Department of Therapeutic Radiology, Yale University School of Medicine
Abstract Preview: Purpose: Superficial radiation therapy uses low-energy x-rays to treat various types of cancers, including non-melanoma skin cancers, and dermatological conditions such as keloid scars, mycosis fungoi...
Authors: Frank F. Dong, Megan C. Jacobsen, Ke Li, Xinming Liu, Humberto Monsivais, John Rong
Affiliation: Purdue University, UT MD Anderson Cancer Center
Abstract Preview: Purpose: To investigate the noise characteristics of a clinical photon counting detector CT (PCD-CT) system along axial and through-plane (Z) dimensions using 3D NPS measurements.
Methods: This stu...
Authors: Rafael Carballeira, Tianyuan Dai, David J. Gladstone, Philip Von Voigts-Rhetz, Rongxiao Zhang
Affiliation: Shandong Cancer Hospital, Dartmouth College, IntraOp, Thayer School of Engineering, Dartmouth College, University of Missouri
Abstract Preview: Purpose: To analyze phase space (PHSP) data generated for Mobetron in FLASH radiotherapy and assess key dosimetric characteristics, including the energy spectrum, scattering angle distribution, and pe...
Authors: Siyong Kim, Ava Paek, Joseph B. Schulz, James J. Sohn, Eric D. Stolen, Ethan D. Stolen
Affiliation: Department of Radiation & Cellular Oncology, University of Chicago, University of Central Florida, Virginia Commonwealth University, Department of Radiation and Cellular Oncology, University of Chicago, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: The American Association of Physicists in Medicine Task Group 142 (AAPM TG-142) guidelines recommend three measurements during monthly quality assurance to keep results within two standard de...
Authors: Eric S. Diffenderfer, Lei Dong, Alejandro Garcia, Wenbo Gu, Michele M. Kim, Alexander Lin, Kai Mei, Peter B. Noël, Boon-Keng Kevin Teo, Lingshu Yin, Jennifer Wei Zou
Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania
Abstract Preview: Purpose: We present a novel 3D-printed range-modulating devices with spatially modulated density for FLASH particle therapy. By varying density distributions, spread-out Bragg peaks(SOBPs) can be gene...
Authors: Ryan Burri, Nazanin Hoshyar, Jerry W. McCoy, Yulin Song, Huma Syed
Affiliation: Bay Pines VA Medical Center
Abstract Preview: Purpose: The study aimed to streamline traditionally manual, iterative, and time-consuming VMAT commissioning process. The goal was to identify an optimal set of MLC dosimetric parameters that minimiz...
Authors: Dong Wook Kim, Jin Sung Kim, Dongho Lee, Sangmin Lee
Affiliation: Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of (South)
Abstract Preview: Purpose:
This study aims to analyze the characteristics of a novel detector based on a dielectric layer (Vieworks Co., Korea), which demonstrates high tolerance to high radiation doses and light tr...