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Results for "outcome risks": 61 found

A Causal Machine Learning Analysis of Dosimetric and Clinical Predictors of Osteoradionecrosis in Head and Neck Cancer Radiotherapy

Authors: Jingyuan Chen, Sheng Li, Tianming Liu, Wei Liu, Zhengliang Liu, Zhong Liu, Daniel Ma, Samir H. Patel, Guangya Wang, Yunze Yang

Affiliation: University of Miami, Mayo Clinic, School of Data Science, University of Virginia, School of Computing, University of Georgia, Department of Radiation Oncology, Mayo Clinic, Institute of Western China Economic Research, Southwestern University of Finance and Economics

Abstract Preview: Purpose:
Traditional patient outcome analyses relied heavily on conventional statistical models that primarily elucidate correlation rather than causal relationships. In this study, we aim to ident...

A Dosimetric Investigation into the Potential of Aperture-Based Techniques to Improve the Clinical Outcomes of Single-Energy Proton Bragg Peak Flash Therapy for Ocular Cancers

Authors: Arpit M. Chhabra, J Isabelle Choi, Minglei Kang, Haibo Lin, Hang Qi, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Xingyi Zhao, Ajay Zheng

Affiliation: New York Proton Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Pencil beam scanning (PBS) proton therapy effectively treats ocular cancer by minimizing exit doses to normal tissues. However, challenges remain in sparing nearby organs-at-risk(OARs). Ul...

A Framework for Automated Selection of Dose-Volume Objectives to Improve Radiation-Induced Immune Suppression (RIIS)-Related Overall Survival (OS) Following Chemo-Radiotherapy

Authors: Gabriel Lucas Andrade de Sousa, Einsley-Marie Janowski, Cam Nguyen, Krishni Wijesooriya

Affiliation: Department of Radiation Oncology, University of Virginia, Department of Physics, University of Virginia

Abstract Preview: Purpose: Optimizing radiation therapy (RT) to spare the immune system may improve Overall Survival (OS) in cancer patients. This study develops a computational algorithm to identify optimal dose-volum...

A Method to Reduce Workload in Adaptive Radiotherapy

Authors: Ramesh Boggula, Lincoln Houghton

Affiliation: Karmanos Cancer Institute, Wayne State University

Abstract Preview: Purpose: To evaluate an approach that selectively applies adaptive re-planning only when needed to reduce clinical workload while maintaining treatment quality. Daily adaptive radiotherapy (ART) has t...

Advocating for Survival Prediction Models in Risk Stratification for Cancer Treatment Outcomes

Authors: Meixu Chen, Jing Wang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center

Abstract Preview: Purpose: Cancer treatment outcome prediction plays a pivotal role in guiding therapeutic decisions and optimizing patient care. Traditionally, binary prediction models have been widely used for risk s...

Assessing the Need for Online Adaptive Prostate SBRT Using the MR-Linac

Authors: Awens Alphonse, Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Samuel Richter, Lauren A. Rigsby, Tino Romaguera, Hina Saeed, Nishan Shrestha, Somol Sunny

Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: This study evaluates the necessity and potential benefits of online adaptive stereotactic body radiotherapy (SBRT) for prostate cancer using the ViewRay MR-Linac system. By leveraging real-ti...

Automated Treatment Planning for Stereotactic Recurrent Head and Neck Cancers Using Knowledge-Based Planning, Multicriteria Optimization, and Dosimetric Scorecards

Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Demonstration of automated stereotactic treatment planning for recurrent head and neck (RHN) cancers using knowledge-based planning, multicriteria optimization (MCO), and dosimetric scorecard...

Case-By-Case Analysis of Proton Spot Spacing and Dosimetric Variability in Proton Arc Lung Cancer Planning

Authors: Nebi Demez, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Umesh Rana, Nishan Shrestha, Somol Sunny

Affiliation: Florida Atlantic University, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: DynamicARC is an advanced proton therapy technique that leverages pencil beam scanning to deliver dose to the patient while the gantry rotates around the patient. This study investigates the ...

Comparative Evaluation of Dosimetric Treatment Plan Quality for Truebeam, and Tomotherapy in Spatially Fractionated Radiation Therapy

Authors: Raghavendiran Boopathy, Mansoor Khan, Srinidhi Rajagopalan

Affiliation: University of Oklahoma, University of Oklahoma Health Sciences Center

Abstract Preview: Purpose: This study aims to evaluate and compare the dosimetric outcomes of spatially fractionated radiotherapy (SFRT) grid planning techniques using Varian Eclipse for a Varian Edge C-arm LINAC syste...

Correlation of Dose Volume Metrics with Skin Systemic Sclerosis 12 Months Post Radiotherapy for Head & Neck Cancer

Authors: Gregory A Azzam, Danielle Cerbon, Laura Huang, Panayiotis Mavroidis, Diana Molinares, Stuart E Samuels, Sotirios Stathakis

Affiliation: Mary Bird Perkins Cancer Center, University of Miami Sylvester Comprehensive Cancer Center, Mount Vernan Rehabilitation Medicine Associates, Department of Radiation Oncology, University of Miami, University of North Carolina

Abstract Preview: Purpose: This study examines the correlation of different dose volume metrics of the skin, sternocleidomastoid (SCM) muscle and subcutaneous tissue (subcut) structures with the skin systemic sclerosis...

Deep Learning-Based Segmentation for Precision Radiation Therapy in Breast Cancertreatment

Authors: Hamdah Alanazi, Silvia Pella

Affiliation: FAU, Florida Atlantic University

Abstract Preview: Purpose: The appearance of breast cancer in the global list of most common cancers worldwide requires
research for ultimate treatment approaches including radiation therapy to reduce deaths from br...

Development and Validation of a Scalable Radiomics Pipeline for Lung Cancer Research Using Clinical and Public Datasets

Authors: Pradeep Bhetwal, Yingxuan Chen, Wookjin Choi, Michael Dichmann, Adam Dicker, Rupesh Ghimire, Yevgeniy Vinogradskiy, Maria Werner-Wasik

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: Radiomics has emerged as a powerful tool in medical research. However, the lack of standardized and reproducible pipelines limits its clinical adoption. This study developed a robust and scal...

Development of a Comprehensive Thoracic Re-Irradiation Database and Investigation of Time-Dependent Dose-Recovery Dynamics for Toxicity Modeling

Authors: Victoria Doss, Tsion Gebre, Rachel B. Ger, Esi A Hagan, Elaina Hales, Russell K Hales, Xun Jia, Heng Li, Dezhi Liu, Todd R. McNutt, Meti Negassa, Anas Obaideen, Tinker Trent, K. Ranh Voong, Cecilia FPM de Sousa

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: As cancer care advances, more patients require re-irradiation, yet evidence-based data is lacking. This study aimed to develop a thoracic re-irradiation database and explore time-dependent re...

Development of a Knowledge-Based Planning Model for Intensity Modulated Proton Therapy in Breast Cancer Treatment

Authors: Parker Anderson, Elizabeth L. Bossart, Jonathan Cyriac, Nesrin Dogan, Robert Kaderka, Yihang Xu

Affiliation: University of Miami, University of Miami, Sylvester Comprehensive Cancer Center, University of Miami Sylvester Comprehensive Cancer Center

Abstract Preview: Purpose:
Knowledge-based planning (KBP) can enhance the treatment planning process in cancer radiotherapy (RT). By training a KBP model with high-quality treatment plans developed by experts, dose-...

Dosimetric Comparison of Lattice and 3D Grid VMAT Planning for Spatially Fractionated Radiotherapy

Authors: Minbin Chen, Gang Liu, Manju Liu, Weiwei Sang, Pulin Sun, Mingyuan Ye, Fang-Fang Yin, Lihua Zhang, Haiming Zhu

Affiliation: Jiahui International Hospital, Radiation Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Medical Physics Graduate Program, Duke Kunshan University, Duke Kunshan University, The First People's Hospital of Kunshan

Abstract Preview: Purpose: This study aims to conduct a dosimetric comparison between lattice radiotherapy (LRT) and 3D grid treatment planning techniques, focusing on their differences in delivering three-dimensional ...

Dosimetric Comparison of MR-Linac Vs. Cyberknife for Prostate Stereotactic Body Radiation Therapy

Authors: Awens Alphonse, Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Tino Romaguera, Hina Saeed, Nishan Shrestha, Somol Sunny

Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: Prostate stereotactic body radiation therapy (SBRT) requires precise dose delivery to the target volume and organ-at-risk (OAR) sparing. This study compares MR-Linac (MRL) and CyberKnife (CK)...

Dosimetric Feasibility of Dominant Intraprostatic Lesion Dose Escalation in HDR Prostate Brachytherapy

Authors: Abby E. Besemer, Carolyn Eckrich, John M. Floberg, Michael J. Lawless, Jessica R. Miller, Joseph B. Schulz, Jordan M. Slagowski, Autumn E. Walter-Denzin

Affiliation: University of Wisconsin-Madison Department of Medical Physics, University of Wisconsin-Madison Department of Human Oncology, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Radiation Oncology, Stanford University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: The aim of this treatment planning study was to evaluate the feasibility of escalating dose with HDR prostate brachytherapy to imaging-identified intraprostatic macroscopic lesions while mode...

Effect of Variation in the ฮฑ/ฮฒ of Cervical Cancer on Clinical Outcomes of Radiation Therapy

Authors: Dennis A. Cheek, Wei Luo, Cameron Thayer-Freeman, Brien Timothy Washington

Affiliation: UT Southwestern Medical Center, University of Kentucky, Department of Radiation Medicine, University of Kentucky

Abstract Preview: Purpose: To investigate the effect of variation in the ฮฑ/ฮฒ of cervical cancer on clinical outcome for cervix cancer patients treated with radiation therapy.
Methods: A distribution of experimentall...

Enhancing Proton Treatment and Mitigating Radiation-Induced Lung Injury Using a Novel Cycle Diffusion Approach for Lung Ventilation Estimation

Authors: Yang Lei, Haibo Lin, Tian Liu, Charles B. Simone, Shouyi Wei, Ajay Zheng

Affiliation: Icahn School of Medicine at Mount Sinai, New York Proton Center

Abstract Preview: Purpose: Radiation-induced lung injury (RILI), encompassing pneumonitis and fibrosis, represents a critical dose-limiting factor in lung cancer radiation therapy. Variability in treatment outcomes is ...

Enhancing Radiotherapy Planning with Machine Learning: Correlating Anatomical Features and Planning Difficulty to Guide Optimal Plan Design

Authors: Li Chen, Shouliang Ding, Xiaoyan Huang, Lecheng Jia, Hua Li, Hongdong Liu, Yanfei Liu, Zun Piao, Guangyu Wang

Affiliation: State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Shenzhen United Imaging Research Institute of Innovative Medical Equipment

Abstract Preview: Purpose: Optimal radiotherapy planning is challenging, influenced by anatomical factors such as surrounding organs and tumor characteristics, which complicate dose distribution and target coverage. Wh...

Evaluating Deep Learning Models for Accurate Segmentation of GTV and Oars in MR-Guided Adaptive Radiotherapy for Pancreatic Cancer

Authors: Christopher G. Ainsley, Pradeep Bhetwal, Yingxuan Chen, Wookjin Choi, Vimal K. Desai, Karen E. Mooney, Adam Mueller, Hamidreza Nourzadeh, Yevgeniy Vinogradskiy, Maria Werner-Wasik

Affiliation: Thomas Jefferson University

Abstract Preview: Purpose: MR-guided adaptive radiotherapy (MRgART) has demonstrated improved outcomes for patients with pancreatic cancer. However, the time-consuming re-segmentation of targets and organs-at-risk (OAR...

Evaluating Three Practical Approaches to Managing Dose Accumulation in Normal Tissues during Radiation Re-Treatments

Authors: Derek A. Fiedler, Nixon Gutierrez, Quyen L. Jones, Zejian Liu, Tatsiana Reynolds

Affiliation: Texas Oncology, Minnesota Oncology, US Oncology

Abstract Preview: Purpose: Optimize patient safety and treatment efficacy during radiation re-treatment planning. Provide a comprehensive comparison of the methods by focusing on their applicability, accuracy, and limi...

Evaluating the Impact of Spot Spacing on Dosimetric Outcomes in Dynamic Arc Proton Therapy for Prostate SBRT

Authors: Nebi Demez, Michael Kasper, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Umesh Rana, Hina Saeed, Nishan Shrestha, Somol Sunny

Affiliation: Florida Atlantic University, Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: DynamicARC is a novel pencil beam scanning (PBS) proton therapy technique with the potential to provide more conformal dose distributions and reduce treatment time. This study investigates th...

Evaluation of Dosimetric Variations from Anatomical Changes in Head and Neck Cancer Patients Treated with Intensity Modulated Proton Therapy

Authors: Chia-Lung Chien, Wen C. Hsi, Romy Megahed, Kayla Schneider

Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Department of Radiation Oncology, University of Arkansas for Medical Sciences

Abstract Preview: Purpose:
The dosimetric variations induced by inter-fractional anatomical changes in intensity-modulated proton therapy could impact the clinic outcomes for head-and-neck (HN) cancer patients. This...

FMEA for Direct to Unit Adaptive Radiotherapy

Authors: Haleem Azmy, Robbie Beckert, Farnoush Forghani, Dean Hobbis, Dan Hong, Hyun Kim, Eric Laugeman, Silpa Raju-Salicki, Domenic Sievert

Affiliation: Washington University in St. Louis School of Medicine, WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine in St. Louis, Washington University School of Medicine, Wash U Medicine, Washington University in St. Louis

Abstract Preview: Purpose: A novel radiation therapy (RT) workflow has recently emerged with the advent of online adaptive RT systems, direct-to-unit (DTU). DTU utilizes online adaptive platforms (MR and CT based) to o...

Feasibility and Dosimetric Impact of Intensity-Modulated Radiotherapy for Cervical Cancer Patients in Nepal: A Retrospective Analysis

Authors: Daniela Branco, John M Bryant, Surendra Bahadur Chand, Pratiksha Shahi, Joseph Weygand

Affiliation: Department of Radiation Oncology and Applied Science, Dartmouth Health, B.P. Koirala Memorial Cancer Hospital, , B.P Koirala Memorial Cancer Hospital, University of California San Diego / California Protons, Department of Radiation Oncology, Moffitt Cancer Center

Abstract Preview: Purpose:
Cervical cancer remains a significant health burden in Nepal, with 2169 new cases and 1313 deaths recorded in 2022. This study evaluates the feasibility of implementing step-and-shoot IMRT...

Free-Breathing VMAT and IMRT Versus Deep Inspiration Breath- Hold 3D-CRT Techniques for Left-Breast Cancer: A Practical Solution for Developing Countries

Authors: Md. Yousuf Ali, Parvin Akhter Banu, Ehteshamul Hoque, Qazi Mushtaq Hussain, Md Jobairul Islam, Md. Abdul Mannan, Sadia Afrin Sarah, Mostafa Aziz Sumon, Ahammad Al Mamun Sweet, AFM Kamal Uddin

Affiliation: Labaid Cancer Hospital & Superspeciality Centre

Abstract Preview: Purpose: Radiotherapy for left-sided breast cancer can induce cardiac injury. Deep Inspiration Breath Hold (DIBH) is a technique that minimizes cardiac exposure during treatment. This study compares d...

From Concept to Clinic: A Phase-Based Approach for Implementing Auto-Segmentation in Radiation Therapy

Authors: Elizabeth L. Covington, Robert T. Dess, Charles S. Mayo, Michelle L. Mierzwa, Dan Polan, Jennifer Shah, Claire Zhang

Affiliation: University of Michigan, Department of Radiation Oncology, University of Michigan

Abstract Preview: Purpose: Auto-segmentation improves contour consistency and standardization in radiation therapy but may introduce variations from current practices, potentially impacting treatment outcomes and toxic...

Impac of Respiratory Motion on Dosimetric and Biological Outcomes in Lung Cancer SIB-SBRT: A 4D Dose Calculation Approach

Authors: Xiangli Cui, Lingling Liu

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences

Abstract Preview: Purpose:
Respiratory motion introduces substantial dose uncertainties in lung cancer radiotherapy, particularly affecting dose distribution in Simultaneous Integrated Boost-Stereotactic Body Radiot...

Impact of Tumor-to-Normal Ratio and Glass Microsphere Particle Density on Local Progression-Free Survival Following Lobar Yttrium-90 Radioembolization

Authors: Jason Chiang, Magnus Dahlbom, Veronica Hankil, Xinyi Li, Catherine (Caffi) Meyer, Kyung Hyun Sung

Affiliation: UCLA, University of California, Los Angeles

Abstract Preview: Purpose:
Yttrium-90 (90Y) radioembolization is a well-established therapy for large or multifocal liver tumors. Accurate dosimetry is critical but remains challenging, as low particle density risks...

Influence of the ฮฑ/รŸ Ratio on Dose Constraints in Radiotherapy of Prostate Cancer

Authors: Marwa Y. Abdel Tawwab, Amin E Amin, Abdullah M. ElSharif, Somaia Metwally Elsayed, Magdy M. Khalil

Affiliation: School of Applied Health Science, Badr University in Cairo (BUC), Cairo, Egypt, Medical Physics, Radiation Oncology Department, Faculty of Medicine, Ain Shams University, Medical Biophysics, Department of Physics, Faculty of Science, Helwan University

Abstract Preview: Purpose: Prostate cancer radiotherapy typically employs conventional fractionation schedules over approximately eight weeks. This study investigates the effect of variations in the ฮฑ/ฮฒ ratio on dose c...

Intraoperative Dynamic Contrast-Enhanced Fluorescence Imaging in Quantifying Tissue Perfusion of Amputation Patients

Authors: Logan M. Bateman, Xu Cao, Jonathan T. Elliott, Lillian A. Fisher, Ida Leah Gitajn, Xinyue Han, Eric R. Henderson, Shudong Jiang, Jessica M. Sin, Yue Tang

Affiliation: Dartmouth College, Dartmouth-Hitchcock Medical Center

Abstract Preview: Purpose: Adequate tissue perfusion is essential for fracture healing and infection prevention, as it supplies oxygen, nutrients and antibiotics to the injury area. However, current methods of assessin...

Investigating Gammatile Migration: Implications for Dosimetry and Clinical Outcomes

Authors: Wesley A. Belcher, Robert A. Corns, Jae Won Jung, Matthew S Peach, Swarup Sharma

Affiliation: The University of North Carolina at Chapel Hill, East Carolina University Brody School of Medicine

Abstract Preview: Purpose: GammaTiles are a novel intracranial brachytherapy approach designed to directly deliver radiation therapy to residual or recurrent brain tumors following resection. Despite their promising th...

Investigating Pitch Factor on Plan Quality in Patients Treated with Hippocampal Avoidance Whole Brain Radiotherapy Using Volo Ultra-Optimized Helical Tomotherapy Plans

Authors: Awens Alphonse, Nebi Demez, Noufal Manthala Padannayil, Shyam Pokharel, Suresh Rana, Lauren A. Rigsby, Gagandeep Saini, Nishan Shrestha, Somol Sunny

Affiliation: Lynn Cancer Institute, Boca Raton Regional Hospital, Baptist Health South Florida

Abstract Preview: Purpose: This study examined the impact of varying the pitch factor in hippocampal-avoidance whole-brain (HP-WB) radiotherapy treatments, utilizing the newly introduced VOLO Ultra optimization for Hel...

Mesh-Based Multiregion Model of Adult Human Kidneys for Dosimetric Evaluation of Radiopharmaceutical Therapy

Authors: John P. Aris, Wesley E. Bolch, Chansoo Choi, Carlos G. Colon-Ortiz, Robert Joseph Dawson, Abdul-Vehab Dozic, Amy M. Geyer, Harald Paganetti, Shreya P. Pathak, Julia D. Withrow

Affiliation: St. Luke's Health System, Massachusetts General Hospital, University of Florida

Abstract Preview: Purpose: The goal of this study was to enhance the accuracy of renal dosimetry in radiopharmaceutical therapy (RPT) by developing a more detailed and precise kidney model. In RPT, accurate dose estima...

Mitigating Data-Driven Uncertainty in Machine Learning-Based Radiotherapy Outcome Prediction

Authors: Ali Ajdari, Alice Bondi, Thomas R. Bortfeld, Gregory Buti, Xinru Chen, Zhongxing Liao, Antony John Lomax, Ting Xu

Affiliation: The University of Texas MD Anderson Cancer Center, Department Of Radiation Oncology, Massachusetts General Hospital (MGH), Massachusetts General Hospital & Harvard Medical School, Paul Scherrer Institut, ETH Zurich

Abstract Preview: Title: Addressing Imaging and Biomarker-driven Uncertainty in Machine Learning-based Radiotherapy Outcome Prediction
Alice Bondi, Gregory Buti, Antony Lomax, Thomas Bortfeld, Xinru Chen, Ting Xu, Z...

Multi-Variat, Multi-Model, and Multi-Patient: From Pure Feasibility to Generalizability in Machine Learning Outcome Prediction Model-Based Treatment Plan Optimization

Authors: Martin Frank, Oliver Jรคkel, Niklas Wahl

Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Karlsruhe Institute of Technology (KIT)

Abstract Preview: Purpose: Machine learning (ML) models on normal tissue complication and tumor control probability ((N)TCP) exploiting e.g. dosiomic and radiomic features are playing an increasingly important role in ...

NTCP Modeling of Skin Systemic Sclerosis 12 Months Post Radiotherapy for Head & Neck Cancer

Authors: Gregory A Azzam, Danielle Cerbon, Laura Huang, Panayiotis Mavroidis, Diana Molinares, Stuart E Samuels, Sotirios Stathakis

Affiliation: Mary Bird Perkins Cancer Center, University of Miami Sylvester Comprehensive Cancer Center, Mount Vernan Rehabilitation Medicine Associates, Department of Radiation Oncology, University of Miami, University of North Carolina

Abstract Preview: Purpose: This study aims at performing a normal tissue complication probability (NTCP) modeling by fitting the doses to the skin, sternocleidomastoid (SCM) muscle and subcutaneous tissue (subcut) stru...

Navigating the Challenges of Telehealth in Radiation Oncology: Risks, Mitigation Strategies, and Future Directions

Authors: Ara Alexandrian, Panayiotis Mavroidis, Sotirios Stathakis

Affiliation: Mary Bird Perkins Cancer Center, University of North Carolina

Abstract Preview: Purpose: Telehealth has transformed healthcare delivery by improving accessibility and convenience for patients and providers. In radiation oncology, telehealth supports consultations, follow-ups, and...

Optimizing Fractionation Schedules for De-Escalation Radiotherapy in Head and Neck Cancers Using Deep Reinforcement Learning

Authors: Zhongjie Lu

Affiliation: Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine

Abstract Preview: Purpose: Patients with locally-advanced head and neck squamous cell carcinomas(HNSCCs), particularly those related to human papillomavirus(HPV), often achieve good locoregional control(LRC), yet they ...

Optimizing Minimum Monitor Unit Thresholds for Proton Breast Therapy on the Iba Proteusone

Authors: Chia-Lung Chien, Wen C. Hsi, Faraz Kalantari, Pouya Sabouri, Man Yam

Affiliation: Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS)

Abstract Preview: Purpose:
Reducing treatment delivery time is critical to improving patient throughput and minimizing the risk of intrafraction motion, which can compromise treatment accuracy. This study identifies...

Personalized Radiotherapy: A Novel Approach to Multi-Criteria Optimization with Patient-Specific Risk Integration

Authors: Ali Ajdari, Thomas R. Bortfeld, Zhongxing Liao, Mara Schubert, Katrin Teichert

Affiliation: The University of Texas MD Anderson Cancer Center, Department Of Radiation Oncology, Massachusetts General Hospital (MGH), Massachusetts General Hospital & Harvard Medical School, Fraunhofer ITWM

Abstract Preview: Purpose: Radiotherapy (RT) treatment planning often involves solving a multi-criteria optimization (MCO) problem. Conventionally, MCO considers a set of generic (population-wide) dosimetric criteria, ...

Physician-Centered Decision-Making Tool for Individualized Outcome-Based Treatment Planning

Authors: Soren Bentzen, Arezoo Modiri, Zaker Rana, Amit Sawant, Lena Specht, Ivan Vogelius

Affiliation: University of Maryland, University of Maryland in Baltimore, Dept. Of Oncology Copenhagen University Hospital โ€“ Rigshospitalet, Maryland University Baltimore, Department of Radiation Oncology, University of Maryland School of Medicine

Abstract Preview: Purpose: There is wide inter-physician radiotherapy planning variability for lymphomas and no systematic way to individualize a plan with respect to patient-specific outcome risks. In response to this...

Proton Vs Photon Therapy for Stereotactic Arrhythmia Radioablation of Ventricular Tachycardia

Authors: Chih-Wei Chang, Kristin A Higgins, Xiaojun Jiang, Pretesh Patel, Justin R. Roper, Keyur Shah, Sibo Tian, Zhen Tian, Yinan Wang, Xiaofeng Yang, Jun Zhou

Affiliation: Department of Radiation Oncology, City of Hope Cancer Center Atlanta, Emory University, University of Chicago, Department of Radiation Oncology and Winship Cancer Institute, Emory University

Abstract Preview: Purpose: Ventricular tachycardia (VT) is a life-threatening arrhythmia commonly treated with catheter ablation; however, some cases remain refractory to conventional treatment. Stereotactic arrhythmia...

Radiobiological Modeling of Tumor Control and Normal Tissue Response Following Mlc-Based Sfrt to Extensive Breast and Chest Wall Tumors

Authors: Ramesh Boggula, Yash Somnay, Hualin Zhang

Affiliation: Radiation Oncology, Keck School of Medicine of USC, Wayne State University

Abstract Preview: Purpose: Spatially fractionated radiation therapy (SFRT) allows delivery of therapeutic doses to bulky tumors otherwise limited by dose-volume effects that threaten organ-at-risk tolerances. For negle...

Rectal Spacer Injection on the Day of HDR Prostate Brachytherapy Enhances Dosimetry and Reduces Rectal Dose for Patients Receiving Combined Brachytherapy and EBRT.

Authors: Francis A Asamoah, David D. Campos, Jordan A Holmes, Ke Colin Huang, Omar Ishaq, Sook Kien Ng, Arpan Prabhu, Edwin Quashie, Yong Yue

Affiliation: Indiana University School of Medicine, Department of Radiation Oncology

Abstract Preview: Purpose: Evaluate a novel rectal spacer workflow with spacer injection during brachytherapy to streamline logistics, reduce hospital visits and costs, and compare the benefits of SpaceOAR Vue and Barr...

Retrospective Study Using Avi Planner for Head and Neck Cancer Cases: Our Experience at Nsia-Luth Cancer Center, South - West Nigeria

Authors: Adebayo Abe, Samuel Olaolu Adeneye, Eben Aje, Bidemi I. Akinlade, Inioluwa Damilola Ariyo, Lilian Ekpo, Muhammad Habeebu, Adedayo O. Joseph, Charles S. Mayo, Noah Ndianaobong, Ikechi S Ozoemelam, Margaret Dideolu Taiwo, Godwin Uwagba

Affiliation: University of Michigan, University of Ibadan, University of Lagos, Missouri University of Science and Technology, NSIA-LUTH Cancer Center, University of Lagos, NSIA-LUTH Cancer Centre, NSIA-LUTH Cancer Center

Abstract Preview: Purpose:
Head and neck cancers (HNC) present significant challenges in radiotherapy due to complex anatomy and the proximity to critical organs at risk (OARs). These challenges are compounded in na...

Scissor-Beam Based Carbon Ion Minibeam Treatment Planning Method

Authors: Hao Gao, Qiang Li, Yuting Lin, Wei Wang, Wei Wu, Weijie Zhang

Affiliation: Institute of Modern Physics, Chinese Academy of Sciences, China, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Carbon minibeam radiation therapy (cMBRT) offers high peak-to-valley dose ratio (PVDR) and relative biological effectiveness. A key challenge is balancing uniform target coverage with PVDR pr...

Scoring Functions for Reinforcement Learning in Accelerated Partial Breast Irradiation Treatment Planning

Authors: Rafe A. McBeth, Kuancheng Wang, Ledi Wang

Affiliation: Department of Radiation Oncology, University of Pennsylvania, Georgia Institute of Technology, University of Pennsylvania

Abstract Preview: Purpose:
The integration of AI in clinical workflows presents unprecedented opportunities to enhance treatment quality in radiation oncology, yet it also demands innovative approaches to address th...

Standardized MRI-CT Hybrid Workflow for High-Dose-Rate Image-Guided Adaptive Brachytherapy in Cervical Cancer: Aapm TG-303 Implementation

Authors: Kim Creach, Kim Howard, Julius G. Ojwang, Richard A. Shaw, Neelu Soni

Affiliation: Mercy Hospital Springfield

Abstract Preview: Purpose: To present a standardized MRI-CT hybrid workflow for High-Dose-Rate (HDR) Image-Guided Adaptive Brachytherapy (IGBT) in cervical cancer, aligned with AAPM TG-303, as a model to assist with im...

TCP Modeling of Regional Recurrencies and Dose to Nodal GTV after Radiotherapy for Head & Neck Cancer

Authors: Brian M. Anderson, Simon A. Brundage, Xuguang Scott Chen, Shiva K. Das, Felice Dong, Spencer Lynch, Panayiotis Mavroidis, Ryan Morse Morse, Heidi Urquidi

Affiliation: University of North Carolina Chapel Hill, University of North Carolina at Chapel Hill, University of North Carolina

Abstract Preview: Purpose: This study aims at correlating different dosimetric indices of nodal GTV with the regional recurrencies observed after head and neck radiotherapy. Also, to perform a tumor control probability...

The Biological TCP/NTCP Modelling on Oropharyngeal Head-and-Neck Cancer for Patients Treated with Proton Beam Therapy

Authors: Wen C. Hsi, Tae Kyu Lee, Biniam Yo Tesfamicael

Affiliation: Allina Health, Department of Radiation Oncology, University of Arkansas for Medical Sciences (UAMS), Oklahoma Proton Center

Abstract Preview: Purpose: When minimal dose-variations induced by inter-fractional anatomical-changes and positioning-deviation were found for having limited impact on clinic-outcomes of oropharyngeal head-and-neck (H...

The GYN Webapp: A Centralized Tool for Enhancing HDR Brachytherapy Treatment Quality and Clinical Outcomes

Authors: Kevin Albuquerque, Ti Bai, Yesenia Gonzalez, Brian A. Hrycushko, Zohaib Iqbal, Paul M. Medin, Shanshan Tang

Affiliation: Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose: Cervical cancer remains one of the most common and significant gynecological (GYN) malignancies globally, often presenting at advanced stages where radiation therapy and high-dose-rate (HDR) ...

The Role of AI-Based Analysis in Segmenting Sealing Zones and Tissue Characterization

Authors: Sara Allievi, Stefano Bonvini, Gloria Miori, Laura Orsingher, Andrea Passerini, Igor Raunig, Daniele Ravanelli, Erich Robbi, Annalisa Trianni

Affiliation: Department of Information Engineering and Computer Science, University of Trento, Vascular Surgery Department, S.Chiara Hospital, APSS, Medical Physics Department, S.Chiara Hospital, APSS

Abstract Preview: Purpose:
This study evaluates the performance of an AI-driven tool in segmenting and analyzing tissue composition in abdominal aortic aneurysm (AAA) patients, specifically focusing on the sealing z...

Transforming CT Technologist Training: Real-Time Feedback, Gamification, and Phantom-Based Education for Accurate Patient Positioning

Authors: Rebecca Lamoureux, Zahra (Zara) Razi, Zachary Whipps

Affiliation: University of New Mexico Hospital

Abstract Preview: Purpose: Patient mispositioning in CT imaging contributes to inconsistent radiation dose delivery and suboptimal image quality, impacting patient safety and diagnostic outcomes. This study evaluates a...

Tumor Dose Escalation for Recurrent Head and Neck SRT Via a Hyperarc-Based Rapidplan Model

Authors: Shane McCarthy, Damodar Pokhrel, William St. Clair, Eddy S Yang

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Demonstrating the feasibility of dose escalation for stereotactic recurrent head and neck (RHN) cancers through the deployment of a Hyper-Arc Based RapidPlan (HARP) model through an Eclipse S...

Uncertainty in Contralateral Breast Dose Reconstruction for Breast Cancer Radiotherapy Patients in the United States between 1990 and 2012

Authors: Amy Berrington de Gonzalez, David Borrego, Rochelle Curtis, Gretchen L Gierach, Jae Won Jung, Choonik Lee, Choonsik Lee, Matthew Mille, Lene Veiga, Jacqueline Vo

Affiliation: University of Michigan, East Carolina University, Radiation Protection Division, Office of Radiation and Indoor Air, U.S. Environmental Protection Agency, National Cancer Institute, Institute of Cancer Research

Abstract Preview: Purpose: Radiotherapy is vital for treating breast cancer, but its long-term health effects remain a concern. Accurate dose reconstruction is crucial for evaluating risks in retrospective epidemiologi...

Using Bayesian Analysis to Quantify the Impact of Clinical and Dosimetric Features for Predicting Swallowing Dysfunction in Oropharyngeal Cancer after Radiotherapy

Authors: Matthew D Blackledge, Christopher M. Nutting, Anju Mohanan Kaimal, Justine Tyler, Konstantinos Zormpas-Petridis

Affiliation: Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, The Institute of Cancer Research

Abstract Preview: Purpose: Swallowing dysfunction (dysphagia) is a common side effect of radiotherapy for oropharyngeal cancer, significantly affecting patient's quality of life. This study aims to investigate the rela...

Utilizing Large Language Models for Efficient and Accurate Clinical Data Enrichment

Authors: Ara Alexandrian, Jessica Ashford, Jean-Guy Belliveau, Allison Dalton, Nathan Dobranski, Krystal M. Kirby, Garrett M. Pitcher, David E. Solis, Hamlet Spears, Angela M. Stam, Sotirios Stathakis, Jason Stevens, Rodney J. Sullivan, Sean Xavier Sullivan, Natalie N. Viscariello

Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center, The University of Alabama at Birmingham, University of Alabama at Birmingham

Abstract Preview: Purpose: To improve retrospective risk analysis in radiation oncology by leveraging Large Language Models (LLMs) to extract richly annotated data from unstructured clinical incident reports.
Method...

Voxel-Based Radiobiological Modelling for Evaluating Radiotherapy Treatment Plans in Relation to Radiation-Induced Acute Mucosal Toxicity (including oral and pharyngeal mucositis): A Single-Institutional Study Focused on Head-and-Neck Carcinoma.

Authors: Rama Bhawani, Mary Joan, Ajay Katake, Munish Kumar, Chhape Ram, Megha Sharma, Balbir Singh, Vikram Singh

Affiliation: SLBSGMC & HOSPITAL, MOHANDAI OSWAL HOSPITAL, WOCKHARDT HOSPITAL, Christian Medical College and Hospital,, AMERICAN ONCOLOGY INSTITUTE

Abstract Preview: Purpose: This study aims to evaluate the utility of voxel-based radiobiological modelling in assessing IMRT radiotherapy treatment plans concerning radiation-induced acute mucosal toxicity, specifical...

Whole Heart Sparing Ethos Adaptive Radiotherapy for Lung Cancer

Authors: Ibrahim Aref, David Bergman, Justine M. Cunningham, Payton Dolan, Aharon Feldman, Yimei Huang, Joshua P. Kim, Brett M. Miller, Emily Moats, Benjamin Movsas, Kundan S Thind

Affiliation: Henry Ford Health

Abstract Preview: Purpose: Cardiac radiation dose is directly associated with adverse cardiac events which are predictive of mortality in lung cancer patients. In fractionated lung radiotherapy, studies have shown a hi...