Authors: John Paul Ortiz Bustillo, Elette Engels, Elrick T. Inocencio, Michael Lerch, Julia Rebecca D Posadas, Anatoly Rosenfeld, Kiarn Roughley, Moeava Tehei, Gordon Wallace, Danielle Warren, Vincent de Rover
Affiliation: Centre for Medical Radiation Physics, University of Wollongong Australia, Department of Radiology, University of the Philippines- Philippine General Hospital, Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong Australia, Centre for Medical Radiation Physics, University of Wollongong, Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, University of the Philippines Manila; Centre for Medical Radiation Physics, University of Wollongong Australia
Abstract Preview: Purpose: To compare the biological response through cell viability assay and fluorescence imaging of 3D bioprinted brain cancer (glioma) constructs relative to 2D monolayer and 3D spheroid culture for...
Authors: John P. Aris, Wesley E. Bolch, Madison Bushloper, Lauren E Ellis, Adam Grey Haneberg, Elizabeth Martin, Bonnie N. C. President, Andrew Robert Sforza, Alexander Zorrilla
Affiliation: Johns Hopkins University, Biomedical Engineering, University of Florida
Abstract Preview: Purpose: To develop six additional high-fidelity 3D models of kidney renal cortical labyrinth from H&E-stained histology slides to support radiation dosimetry in radiopharmaceutical therapies (RPTs).<...
Authors: Shashanksharad Kale, Gopishankar Natanasabapathi, Daya Nand Kishore Sharma
Affiliation: All India Institute of Medical Sciences (AIIMS), Department of Radiation Oncology, All India Institute of Medical Sciences
Abstract Preview: Purpose:
The study demonstrates a novel 3D printing method to fabricate an ion chamber insert (ICI) for absolute dosimetry purpose in gamma knife radiosurgery (GKRS).
Methods:
Our institute u...
Authors: Bryan Bednarz, Malick Bio Idrissou, Campbell Haasch, Reinier Hernandez
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, University of Wisconsin - Madison
Abstract Preview: Purpose: Quantitative optical imaging is a powerful tool in murine models for assessing tumor growth and metastatic spread using bioluminescence imaging (BLI) and for detecting radiopharmaceutical upt...
Authors: Thomas Gee, Sofia Michopoulou, Amit Nautiyal
Affiliation: University Hospital Southampton
Abstract Preview: Purpose: Dosimetry software that is accessible to departments offers new opportunities to improve patient-specific dosimetry. Prior to clinical decision-making, it is essential to validate dosimetry s...
Authors: Phillip Cuculich, Geoffrey D. Hugo, Xiwen Li, Michael T. Prusator, Clifford Robinson, Pamela Samson, Xue Wu
Affiliation: Washington University School of Medicine in St Louis, Washington University School of Medicine in St. Louis, University of Utah, WashU Medicine
Abstract Preview: Purpose:
For development of novel motion management methods it is useful to have a digital phantom capable of realistic simulation of respiratory 4DCT acquisition of the thorax, including cycle-to-...
Authors: Alexandra Christensen, Timothy J. Hall, Ivan M. Rosado-Mendez
Affiliation: University of Wisconsin, Madison, Departments of Medical Physics and Radiology, University of Wisconsin-Madison
Abstract Preview: Purpose: Quantitative ultrasound techniques based on the statistical analysis of speckle are currently being deployed commercially and clinically as sources of biomarkers associated with tissue micros...
Authors: Michael B. Altman, Zhuo Chen, Ella Lawrence, Borna Maraghechi, Ziad H. Saleh
Affiliation: Washington University School of Medicine, WashU Medicine
Abstract Preview: Purpose: Structural shielding design for x-ray facilities, as specified in NCRP Report No. 151, is a detailed process but an important component of Medical Physics graduate and post-graduate education...
Authors: Javier Chiasson, Dominique Guillet, Arthur Lalonde, Karim Zerouali
Affiliation: Universite de Montreal, Centre Hospitalier de l'Universite de Montreal
Abstract Preview: Purpose:
To validate a Monte Carlo (MC) model of a Ultra-High dose rate (UHDR) electron beam using a prototype flashdiamond (fD) detector coupled to an electrostatically shielded beam current trans...
Authors: Ivan M. Buzurovic, Matthew W. Jacobson, Marjan Khosravi
Affiliation: Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology, University of Massachusetts Lowell, Department of Physics, Lowell, MA/Brigham and Women's Hospital, Harvard Medial School, Dana-Farber Cancer Institute, Department of Radiation Oncology
Abstract Preview: Purpose: Annual quality assurance (QA) of high dose rate (HDR) brachytherapy (BT) gynecological (GYN) applicators is critical to ensure accurate and consistent source position and dose delivery. In th...
Authors: Amy Tien Yee Chang, Chi Wai Cheung, Tin Lok Chiu, Chen-Yu Huang, Chi Wa Kong, Pei-Xiong Li, Pak Hang Nam, Bin Yang, Siu Ki Yu
Affiliation: Comprehensive Oncology Centre, Hong Kong Sanatorium and Hospital, Medical Physics Department, Hong Kong Sanatorium and Hospital
Abstract Preview: Purpose: This study introduces BrachyPlanCheck, an independent Monte Carlo (MC)-based dose calculation tool for 192Ir brachytherapy retrospective study or algorithm commissioning.
Methods: BrachyPl...
Authors: Dylan Yamabe Breitkreutz, Lee Chin, Brige P. Chugh, Mark D'Souza, Brian M. Keller, Anthony Kim, Michelle K. Nielsen, Arjun Sahgal
Affiliation: Sunnybrook Health Sciences Centre
Abstract Preview: Purpose: The Elekta Unity MR-linac delivers highly conformal SBRT treatments using IMRT. These treatment plans require patient-specific quality assurance (PSQA) measurements to detect discrepancies be...
Authors: Hamid Aghdam, DJ Chen, Heather Chen, Sharad Goyal, Yonas Solomon Mekuria, Martin Ojong-Ntui, Yuan James Rao
Affiliation: The George Washington University, The George Washington University Cancer Center
Abstract Preview: Purpose: Elekta Leipzig and Valencia Skin applicators are designed to treat skin lesions. The applicators limit the irradiation to the required treatment area using a densimet shielding. Valencia uses...
Authors: Brett Bocian, Patrick James Jensen, Luis Augusto Perles, Christopher J. Tien
Affiliation: Yale University School of Medicine, University of Miami, The University of Texas MD Anderson Cancer Center, UT MD Anderson Cancer Center
Abstract Preview: Purpose: Guidelines for dose prescriptions in endometrial cancer are based upon depth from the cylinder, traditionally 5 mm or 0 mm (i.e., surface). There are no current single-channel vaginal cylinde...
Authors: David H. Abramson, Christopher Barker, Jasmine H. Francis, Meng Wei Ho, Yen-Po Lee, Haibo Lin, Hang Qi, Andy Shim, Charles B. Simone, Weihong Sun, Xiaoxuan Xu, Siyu Yang, Francis Yu, Anna Zhai
Affiliation: College of Machine Intelligence, Nankai University, New York Proton Center, Department of Biomedical Engineering, Johns Hopkins University, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Proton therapy is an effective modality for treating ocular tumors such as uveal melanoma. We developed a novel camera‐based eye‐tracking system to provide real-time noninvasive eye positioni...
Authors: Ting Chen, Siming Lu, Tanxia Qu, Hesheng Wang
Affiliation: NYU Langone Health
Abstract Preview: Purpose: This study, the first in a two-part series, aims to determine the isocenter position and size for the MR Linac UNITY, focusing on the central axis (CAX) alignment of its Multi-Leaf Collimator...
Authors: Tanxia Qu, Hesheng Wang
Affiliation: NYU Langone Health
Abstract Preview: Purpose:
This study, the second in a two-part series, evaluates the isocenter position (the point in 3D space minimizing the sum of Euclidean distances to the MLC's central axis) and isocenter size...
Authors: Md. Jobairul Islam
Affiliation: Department of Radiation Oncology, Labaid Cancer Hospital and Super Speciality Centre
Abstract Preview: Purpose: Electron radiotherapy is an effective treatment for superficial tumors but requires field-shaping devices like electron applicators, which are labor-intensive to produce. This study aimed to ...
Authors: Chang Heon Choi, Minjae Choi, Yoonsuk Huh, Jin Jegal, Jung-in Kim, So-Yeon Park
Affiliation: Department of Radiation Oncology, Veterans Health Service Medical Center, Department of Radiation Oncology, Seoul National University Hospital
Abstract Preview: Purpose: Total Body Irradiation (TBI) aims to achieve a uniform dose distribution across the entire body. However, in conventional TBI setups that use extended source-to-surface distance (SSD) and lea...
Authors: Rajiv Gupta, Rehab Naeem Khalid, Min Lang, Michael H Lev, Quirin Strotzer, Matthew Tivnan, Maryam Vejdani-Jahromi, Dufan Wu, Siyeop Yoon, Chen Zhennong
Affiliation: Massachusetts General Hospital
Abstract Preview: Purpose: Patient motion is a major source of artifacts in portable brain CT due to the slow scanning speed. A diffusion model was developed to reduce these motion artifacts. This work aims to assess t...
Authors: Nguyen Phuong Dang, Mason Hazlett, Lijun Ma, Yutaka Natsuaki, William T. Watkins, Zhengzheng Xu, Timothy Pok Chi Yeung
Affiliation: Reflexion Medical Inc,, Radiation Oncology, Keck School of Medicine of USC, RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center
Abstract Preview: Purpose: This is the first study reporting the beam dosimetric parameter cross-checks of Reflexion linac using different water phantom systems and detectors. The difference in measurements using diffe...
Authors: Caroline Esposito, Keith T Griffin, Jae Won Jung, Choonik Lee, Choonsik Lee, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock
Affiliation: East Carolina University, University of Michigan, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School
Abstract Preview: Purpose: The National Cancer Institute’s Pediatric Proton and Photon Therapy Comparison Cohort aims to collect and analyze data from cancer centers across the United States and Canada to quantify diff...
Authors: Anupama Chundury, Hyejoo Kang, John C. Roeske, Iris A. Rusu
Affiliation: Loyola University Medical Center, Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Stritch School of Medicine Loyola University Chicago, Cardinal Bernardin Cancer Center, Loyola University Chicago
Abstract Preview: Purpose: To quantify the dosimetric impact of six degrees of freedom (6DoF) intrafractional errors on gross tumor volume (GTV) and planning target volumes (PTV) for single-isocenter multi-target stere...
Authors: Ara Alexandrian, Sadiki Daniel
Affiliation: Louisiana State University, Mary Bird Perkins Cancer Center
Abstract Preview: Purpose: To develop a learning-to-optimize machine learning model that accelerates optimization in VMAT treatment planning by training on prostate patient data.
Methods: A treatment plan dataset of...
Authors: Xu Cao, Wesley S. Culberson, Aubrey Parks, Brian W Pogue, William Scott Thomas
Affiliation: Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison
Abstract Preview: Purpose:
The hydrated electron is a critical reactive species generated during the radiolysis of water when ionizing radiation interacts with biological tissues. It plays a pivotal role in mediatin...
Authors: Mohammadreza Ay, Nahal Daneshgar, Nima Kasraie, Abbas Monsef, Zeinab Peymani, Hadi Rezaei, Peyman Sheikhzadeh
Affiliation: University of Minnesota Medical School, Radiation Oncology, Department of Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Shiraz University of Medical Sciences, Department of Medical Physics, Tehran University of Medical Sciences, Department of Medical Physics and Biomedical Engineering, UT Southwestern Medical Center, Imam Khomeini Hospital Complex,Tehran University of Medical Sciences
Abstract Preview: Purpose:
This study aims to design and simulate an innovative pediatric-dedicated SPECT scanner optimized for children’s unique anatomical and safety needs by enhancing sensitivity in data acquisit...
Authors: Ananta Raj Chalise, Matthias K Gobbert, Hajar Moradmand, Sina Mossahebi, Stephen W. Peterson, Jerimy C. Polf, Lei Ren, Ehsan Shakeri, Vijay Raj Sharma, Jie Zhang
Affiliation: University of Maryland School of Medicine, University of Maryland Baltimore County, University of Maryland, University of Maryland, Baltimore County, University of Maryland, School of Medine, Department of Physics, University of Cape Town, M3D, Inc
Abstract Preview: Purpose: We are developing a novel Compton Camera (CC) system mounted orthogonally on the treatment nozzle for prompt gamma (PG) imaging-based proton range verification during treatment. This study in...
Authors: Emily Hansen, Alois M. Ndlovu, Niara Rowe, Roland Teboh
Affiliation: Hackensack University Medical Center
Abstract Preview: Purpose: The accuracy of SCINTIX biology-guided radiotherapy (BgRT) on the RefleXion X1 is dependent on the correct alignment of the isocenter between all subsystems, including setup lasers, kV imagin...
Authors: Ben Piacitelli, Celeste Winters
Affiliation: OHSU, Department of Diagnostic Radiology, Oregon Health & Science University
Abstract Preview: Purpose: To compare recovery coefficients measured with Lu-177 and Tc-99m with the goal of assessing accuracy of the Tc-99m surrogate method and comparing RC reproducibility between scanners of the sa...
Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang
Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...
Authors: Rafael Carballeira, David J. Gladstone, Philippe Liger, Rongxiao Zhang
Affiliation: TheryQ, Dartmouth College, University of Missouri, Thayer School of Engineering, Dartmouth College
Abstract Preview: Purpose: To model a FLASH electron beam system (FLASHLAB) via first principle Monte Carlo methods, navigating installation configurations, shielding and regulatory radiation safety considerations for ...
Authors: Kimyli Lemieux, Xingyu Nie
Affiliation: University of Kentucky/UK HealthCare
Abstract Preview: Purpose: To optimize the selection of calibration radioisotope and its activity for dose calibrator (DC) linearity testing, adhering to ALARA (As Low As Reasonably Achievable) principles while conside...
Authors: Sarah Dumont, Trevor Ketcherside, An Liu, William T. Watkins, Qiuyun Xu
Affiliation: RefleXion Medical, Department of Radiation Oncology, City of Hope National Medical Center
Abstract Preview: Purpose:
The RefleXion X1 SCINTIX algorithm convolves beam fluence with real-time PET distributions for tracking and plan adaptation, but radiotherapy Planning Target Volumes (PTVs) are often signi...
Authors: Jack Neylon
Affiliation: Department of Radiation Oncology, University of California, Los Angeles
Abstract Preview: Purpose: Commissioning surface applicators is notoriously laborious. In addition, when commissioning Varian surface applicators with vertically positioned source, we found limited data and resources a...
Authors: Zakaria Aboulbanine, Greeshma A. Agasthya, Paul Inman, Anuj J. Kapadia, Anthony Hong Cheol Lim, Jayasai Ram Rajagopal
Affiliation: Oak Ridge National Laboratory, Georgia Institute of Technology
Abstract Preview: Purpose: The fundamental concept of radiopharmaceutical therapy involves binding radioisotopes to molecules with a known biokinetic distribution, which ensures that the targeted organs receive higher ...
Authors: Giavanna Luisa Jadick, Patrick J La Riviere, Cailey Riggs
Affiliation: University of Chicago
Abstract Preview: Purpose: We explore the accuracy of physics models for propagation-based x-ray phase-contrast imaging (XPCI) with an eye to future clinical implementation, providing a practical assessment of detectio...
Authors: Tianliang Gu
Affiliation: UT Health Science Center at Houston
Abstract Preview: Purpose:
In Nuclear Regulatory Commission guide 8.39 on releasing patients administered radioactive material, the dose is calculated assuming both the source and receiver are points. This point mod...
Authors: David P. Adam, Xun Jia, Youfang Lai, Yuncheng Zhong
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins University
Abstract Preview: Purpose: Radiopharmaceutical therapy is experiencing a resurgence in interest due to its potential of treating widespread metastatic disease in a patient-specific manner. Accurately measuring and desc...
Authors: Vishruta A. Dumane, Andrew Lukban, Kiran Pant, Charlotte Elizabeth Read, Ren-Dih Sheu, Nadia M. Vassell
Affiliation: Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, Department of Radiation Oncology
Abstract Preview: Purpose: This work introduces a refined in-house modified COMS eye plaque management system to streamline processes, reduce redundancies, and enhance usability.
Methods: A web-based application wit...
Authors: Tirthraj Adhikari, Timothy J Allen, Abdullah A. Alshreef, Clara Ferreira
Affiliation: Medical School Department of Radiation Oncology University of Minnesota, University of Minnesota, Loma Linda University Medical Center
Abstract Preview: Purpose: GammaTile Brachytherapy with 131Cs is an effective treatment for glioblastomas, offering local control with minimal radiation necrosis. While the line source model is preferred for dose distr...
Authors: Avneesh Chhabra, Zhiyue J. Wang, Qing Yuan
Affiliation: University of Texas Southwestern Medical Center
Abstract Preview: Purpose: Magnetic susceptibility artifacts from dental arches and hardware often compromise MRI neurography of jaw and facial nerves. This study aims to characterize these artifacts and provide insigh...
Authors: Michael Evan Chaga, Timothy Chen, Shabbar Danish, Jesse Feng, Joseph Hanley, Georg A. Weidlich
Affiliation: Zap Surgical, Tenafly High School, Jersey Shore University Medical Center
Abstract Preview: Purpose: ZapMU is the first independent monitor unit check software freely available supporting ZAP-X. In this study, the validation of ZapMU for independent check of dose calculation is performed, ut...
Authors: John P. Aris, Wesley E. Bolch, Natalia Estefania Carrasco-Rojas, Ann M. Chan, Chansoo Choi, Aitor Gallastegui Menoyo, Rowan James Milner, Bangho Shin, Maria M. Von Chamier
Affiliation: University of Florida
Abstract Preview: Purpose: In preclinical studies, minipigs serve as valuable experimental models for predicting absorbed doses due to their anatomical and physiological similarities to humans. However, minipig computa...