Authors: Soon N. Huh, Perry B. Johnson, Jiyeon Park, Ryan Stevens
Affiliation: University of Florida Health Proton Therapy Institute, UF Health Proton Therapy Institute, UFHPTI
Abstract Preview: Purpose:
MRI images with minimal artefacts to scan spine with Titanium instrumentation (screws, stabilizing rods, and spacer) are acquired by optimizing scanning parameters of pulse sequences (main...
Authors: Soon N. Huh, Perry B. Johnson, Jiyeon Park, Ryan Stevens
Affiliation: University of Florida Health Proton Therapy Institute, UF Health Proton Therapy Institute, UFHPTI
Abstract Preview: Purpose:
Low-Tesla MRI (0.23T Panorama MR Scanner, Philips) has been used for tumor progression during proton therapy treatments, and for initial contouring in addition to diagnostic MRI. The pulse...
Authors: Jiayi Chen, Manju Liu, Ning Wen, Haoran Zhang, Yibin Zhang
Affiliation: Department of Radiation Oncology, Ruijin Hospital, Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Duke Kunshan University, Department of Radiation Oncology,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Abstract Preview: Purpose: This study introduces a novel Dual Energy CT (DECT)-Guided Intelligent Radiation Therapy (DEIT) platform designed to streamline and optimize the radiotherapy process. The DEIT system combines...
Authors: Ahad Ollah Ezzati, Yile Fang, Xiaoyu Hu, Xun Jia, Kai Yang, Yuncheng Zhong
Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Massachusetts General Hospital, Johns Hopkins University
Abstract Preview: Purpose: With breast cancer being one of the most prevalent cancers, regular screening is an effective strategy to mitigate the risk of malignancy. However, conventional energy-integrating detector (E...
Authors: Dale Black, David Clymer, Huanjun Ding, Hamidreza Khodajou Chokami, Sabee Molloi, Christine Vy Nguyen, Tim Sananikone, Alireza Shojazadeh, Randy Wang
Affiliation: Department of Radiological Sciences, University of California, University of California, Department of Radiological Sciences, University of California, Irvine, Department of Radiological Sciences, University of California, Irvine
Abstract Preview: Purpose: We present a novel multi-material decomposition (MMD) algorithm for accurate quantification of material concentration in reconstructed dual-energy CT images. This method addresses limitations...
Authors: Michael Caulfield, Ye Chen, Yoshihiro Ishi, Yasutoshi Kuriyama, Taeko Matsuura, Naoki Miyamoto, Taichi Murakami, Tomonori Uesugi, Kohei Yokokawa
Affiliation: Hokkaido University, Kyoto University, University of Alberta
Abstract Preview: Purpose: Protoacoustics has the potential for real-time and direct imaging of the Bragg peak. This study investigated the accuracy of the Bragg peak imaging based on the water phantom experiment at a ...
Authors: Cem Altunbas, Farhang Bayat
Affiliation: Department of Radiation Oncology, University of Colorado School of Medicine, Taussig Cancer Center, Cleveland Clinic
Abstract Preview: Purpose:
Low dose imaging and scatter rejection hardware in CBCT reduces X-ray fluence incident on the imager, increasing noise, causing photon starvation artifacts in CBCT images. In this work, we...
Authors: Shaojie Chang, Thomas A. Foley, Hao Gong, Emily Koons, Shuai Leng, Cynthia H. McCollough, Eric E. Williamson
Affiliation: Mayo Clinic
Abstract Preview: Purpose: To enhance coronary CT angiography (cCTA) capabilities on conventional energy integrating detector CT (EID-CT) using artificial intelligence (AI). The AI framework incorporates high-resolutio...
Authors: Zahra Ahmadi Ganjeh, Stefan Both, Peter Dendooven, Jeffrey Free, Brian Zapien Campos
Affiliation: Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Particle Therapy Research Center (PARTREC), Department of Radiation Oncology, University Medical Center Groningen, University of Groningen
Abstract Preview: Purpose: Positron emission tomography (PET) has been investigated for range monitoring in intensity-modulated proton therapy (IMPT), but real-time feedback been limited due to the focus on long-lived ...
Authors: Austen N. Curcuru, Arash Darafsheh, Winter Green, Yao Hao, Baozhou Sun, Tiezhi Zhang, Tianyu Zhao, Xiandong Zhao
Affiliation: WashU Medicine, Washington University School of Medicine, Department of Radiation Oncology, Washington University School of Medicine, Washington University in St. Louis, University of South Florida, Baylor College of Medicine
Abstract Preview: Purpose: Intensity modulated proton therapy (IMPT) requires precise setup imaging due to the sharp dose gradients and rapid distal fall-off seen in proton therapy dose distributions. Additionally, onl...
Authors: Ronald C Chen, Hao Gao, Nicolas Gerard, Harold Li, Yuting Lin, Jarrick Nys, Jufri Setianegara, Mark Szczepanski, Aoxiang Wang
Affiliation: 4Physikalisch-Technische Werkstätten (PTW), Department of Biomedical Engineering, Huazhong University of Science and Technology, Ion Beam Applications (IBA), Department of Radiation Oncology, University of Kansas Medical Center
Abstract Preview: Purpose: Modern synchrocyclotrons can produce magnetically-scanned protons at ultra-high dose-rates (FLASH). However, their pulsed nature leads to high doses-per-pulse (DPP) which can cause non-neglig...
Authors: Brian Burger, Carri K. Glide-Hurst, John W. Hayes, Carson Hoffman, Minglei Kang, Jessica R. Miller, Jordan M. Slagowski, Yuhao Yan
Affiliation: Department of Human Oncology, University of Wisconsin-Madison, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Leo Cancer Care
Abstract Preview: Purpose: The combination of upright CT and patient positioner for particle therapy present tremendous potential for high precision IGRT and online adaptive radiation therapy (ART), where reliable CT p...
Authors: Maria F. Chan, Indra J. Das, Xiuxiu He, Seng Boh Gary Lim, Jeonghoon Park, Yunjie Yang
Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Memorial Sloan Kettering Cancer Center
Abstract Preview: Purpose: There is a need for accurate and flexible in-vivo dosimetry systems, particularly for special procedures. Effective dosimetry is crucial for dose verification and maintaining records. A new r...
Authors: Paul Deak, Yang Li, Mark Pankuch, Yanling Qu, Maggie Stauffer, Hazel Wang
Affiliation: Northwestern Medicine Proton Center, GE, Northwestern Medicine
Abstract Preview: Purpose: The objective is to evaluate Relative Stopping Power(RSP) accuracy of ultra-fast switching KV Dual-Energy CT(DECT) in animal tissue and compare it to the RSP converted from Single Energy CT(S...
Authors: Meghan Lubner, Krista McClure, Aria M. Salyapongse, Timothy P. Szczykutowicz, Giuseppe Toia, Ming Yan, Zhye Yin, Meghan Yue
Affiliation: GE HealthCare, Departments of Radiology and Medical Physics, University Wisconsin-Madison, GE Healthcare, University of Wisconsin-Madison, UW-Madison, University of Wisconsin Madison, Department of Radiology
Abstract Preview: Purpose: To evaluate virtual unenhanced (VUE) and true unenhanced (TUE) human subject images on a prototype deep silicon photon-counting detector (PCD) CT with prototype algorithms.
Methods: 5 subj...
Authors: Afrouz Ataei, Victor Moy, Mark P. Supanich
Affiliation: Rush University
Abstract Preview: Purpose: This study evaluates the impact of ultra-high resolution (UHR) mode on the visualization of small vessels in coronary computed tomography angiography (CTA) using a photon-counting CT scanner....
Authors: Yanle Hu, Shuai Leng, Cynthia H. McCollough, Maryam Sadeghian, Joe Swicklik
Affiliation: Mayo Clinic Arizona, Mayo Clinic
Abstract Preview: Purpose: The dependence of CT number on position in the field-of-view (FOV) imposes challenges in radiotherapy treatment planning. This study aims to decrease this dependence using photon counting det...
Authors: Yanle Hu, Shuai Leng, Cynthia H. McCollough, Maryam Sadeghian, Joe Swicklik
Affiliation: Mayo Clinic Arizona, Mayo Clinic
Abstract Preview: Purpose: To assess the dependency of CT numbers on position in the field-of-view (FOV) using single-energy (SE) and dual-energy (DE) images and energy-integrating detector (EID) and photon-counting de...
Authors: Yaowen Cao, Haonian Gong, Yue Gu, Meiqi Liu, Hsiao-Ming Lu, Yuxiang Wang, Yidong Yang, Xiaogang Yuan
Affiliation: Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Department of Engineering and Applied Physics, University of Science and Technology of China
Abstract Preview: Purpose: Magnetic resonance imaging (MRI)-guided proton therapy is an innovative technology that combines superior soft tissue imaging capabilities of MRI with the high dose conformity of proton thera...
Authors: Ehsan Abadi, Njood Alsaihati, Steven T. Bache, Mridul Bhattarai, Cindy Marie McCabe, Francesco Ria, Ehsan Samei
Affiliation: Duke University, Center for Virtual Imaging Trials, Duke University, Duke University Health System, Clinical Imaging Physics Group, Department of Radiology, Duke University Health System
Abstract Preview: Purpose: To compare and contrast alternative methods including reader (in hominum), phantom (in phantasma), in vivo, and in silico methods deployed to assess the performance of photon counting (PCCT) ...
Authors: Michael Dingfelder, Homeira Faridnejad
Affiliation: East Carolina University, Department of Physics, East Carolina University
Abstract Preview: Purpose: To use Gafchromic film for measurement of the dose delivered by low-energy (2-4 MeV) protons to living cells.
Methods: Five different types of Gafchromic films were tested for dosimetry un...
Authors: Lakshmi Ananthakrishnan, Xinhui Duan, Liqiang Ren, Gary Xu, Kuan Zhang, Yue Zhang
Affiliation: Department of Radiology, UT Southwestern Medical Center, Imaging Services, UT Southwestern Medical Center
Abstract Preview: Purpose: Daily quality control (QC) programs for diagnostic CT include water CT number (HU), standard deviation (SD), and visual artifact evaluations. At our institution, 70 keV virtual monoenergetic ...
Authors: Nobukazu Fuwa, Masato Horita, Takahiro Kato, Ryo Tanokura, Yuki Tominaga
Affiliation: Medical Co. Hakuhokai, Osaka Proton Therapy Clinic, Central Japan International Medical Center, Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University
Abstract Preview: Purpose:
We have installed a new type of scanned proton therapy system (Varian ProBeam 360°TM). This study aimed to evaluate the four different dose calculation algorithms.
Methods:
Sixteen b...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Luuk J Oostveen, Elsa Bifano Pimenta, Ioannis Sechopoulos, Alessandra Tomal
Affiliation: Radboud University Medical Center, University of São Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de Física Gleb Wataghin
Abstract Preview: Purpose: This study aimed to evaluate the precision and accuracy of volume measurements for solid nodules (SNs) and ground-glass opacities (GGOs) in lung images acquired using energy-integrating CT (E...
Authors: Xinhui Duan, Vivek Nair, Liqiang Ren, KyuHo Song, Vasantha Vasan, Kuan Zhang, Yue Zhang
Affiliation: Department of Radiology, UT Southwestern Medical Center
Abstract Preview: Purpose: Minimizing radiation dose is crucial in CT colonography (CTC) screening and diagnosis. Tin (Sn) prefiltration is readily incorporated into clinical photon-counting CT (PCCT) scanners, yet its...
Authors: José Antonio Klautau Toffoli, Anthony G. Tessier, Atiyah Yahya
Affiliation: Department of Oncology, University of Alberta
Abstract Preview: Purpose: To demonstrate that magnetic resonance spectroscopy (MRS) methyl (≈0.9 ppm) to glycerol (≈4.1-4.3 ppm) resonance area ratios correlate with relative concentrations of free fatty acids to trig...
Authors: Niels Bassler, Jonathan Bortfeldt, Francesco Evangelista, Giulio Lovatti, Jasper Nijkamp, Rasmus Nilsson, Munetaka Nitta, Katia Parodi, Marco Pinto, Per R. Poulsen, Brita Singers Sørensen, Peter Thirolf, Erik Traneus, Taiga Yamaya
Affiliation: RaySearch Laboratories AB, National Institutes for Quantum Science and Technology, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital
Abstract Preview: Purpose: Within the SIRMIO project (Small Animal Proton Irradiator for Research in Molecular Image-Guided Radiation Oncology), we aimed to perform the first in vivo proton beam treatment with a dedica...
Authors: Philip Blumenfeld, Jon Feldman, Yair Hillman, Michael Marash, Aron Popovtzer, Alexander Pryanichnikov, Shimshon Winograd, Marc Wygoda, Vered Zivan
Affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), P-Cure Ltd./Inc., Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University of Jerusalem
Abstract Preview: Purpose:
Image-guided adaptive proton therapy (IGAPT) allows tailored dose adjustments to account for anatomical and physiological changes during treatment. Recent efforts have developed a cost-eff...
Authors: Soon N. Huh, Perry B. Johnson, Jiyeon Park, Ryan Stevens
Affiliation: University of Florida Health Proton Therapy Institute, UF Health Proton Therapy Institute, UFHPTI
Abstract Preview: Purpose:
It has been challenging to acquire clinically useful MR images of pediatric cancer patients without anesthesia, and MR contrast agents. Custom-made immobilization devices and optimization ...
Authors: Takahiro Kato, Teiji Nishio, Masataka Oita, Robabeh Rahimi, Yuki Tominaga, Yushi Wakisaka
Affiliation: University of Maryland, Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Medical Co. Hakuhokai, Osaka Proton Therapy Clinic, Medical Physics Laboratory, Division of Health Science, Osaka University Graduate School of Medicine, Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Abstract Preview: Purpose: This study evaluated dose verifications and lateral penumbra improvements for scanned proton therapy plans with and without a multi-leaf collimator (MLC) under various air gaps.
Methods: E...
Authors: Meghan Lubner, Aria M. Salyapongse, Teva Shapiro, Scott D. Slavic, Timothy P. Szczykutowicz, Giuseppe Toia, Zhye Yin
Affiliation: GE HealthCare, Departments of Radiology and Medical Physics, University Wisconsin-Madison, GE Healthcare, University of Wisconsin-Madison, University of Wisconsin - Madison, UW-Madison, University of Wisconsin Madison, Department of Radiology
Abstract Preview: Purpose:
To compare iodine quantification on a prototype deep silicon photon-counting detector (PCD) CT and conventional clinical energy-integrating (EID) dual-energy (DE) CT.
Methods:
A phan...
Authors: Ruiming Chen Edmondson, Darwin Abraham Garcia, James A. Kavanaugh, Joseph John Lucido
Affiliation: Mayo Clinic
Abstract Preview: Purpose: Characterize the dose response and reproducibility of a low-dose film for 6 MV photon beam and assess the film’s energy dependence between kV and MV energies.
Methods: A single 8’x10’ LD-V...
Authors: Christopher P. Favazza, Andrea Ferrero, Taylor Froelich, Forrest Linch, Scott Thompson
Affiliation: Mayo Clinic
Abstract Preview: Purpose: Photon counting detector (PCD) CT is a promising tool to enhance pre-procedural planning and intra-procedural guidance for prostate artery embolization due to its unsurpassed ultra-high spati...
Authors: Gisell Ruiz Boiset, Paulo ROBERTO Costa, Luuk J Oostveen, Elsa Bifano Pimenta, Ioannis Sechopoulos, Alessandra Tomal
Affiliation: Radboud University Medical Center, University of São Paulo (USP), Institute of Physics, Universidade Estadual de Campinas. Instituto de Física Gleb Wataghin
Abstract Preview: Purpose: The study evaluated the accuracy and precision of lung nodule volume measurements, specifically solid nodules (SNs) and ground-glass opacities (GGOs) in different imaging settings.
Methods...
Authors: Afrouz Ataei, Xinhui Duan, Mi-Ae Park, Liqiang Ren
Affiliation: Department of Radiology, UT Southwestern Medical Center, UT Southwestern Medical Center, Rush University
Abstract Preview: Purpose:
Photon-counting CT (PCCT) has become commercially available recently, offering significant potential to enhance patient care. However, it also introduces unique challenges. One such challe...
Authors: Slade J. Klawikowski, Natalya V. Morrow, Haidy G. Nasief, Eric S. Paulson, An Tai, Hualiang Zhong
Affiliation: Department of Radiation Oncology, Medical College of Wisconsin
Abstract Preview: Purpose: Gafchromic film is commonly used for quality assurance in SRS/SBRT. However, its application in low-dose measurements, such as monitoring doses on cardiac implantable electronic devices—where...
Authors: Frank F. Dong, Megan C. Jacobsen, Ke Li, Xinming Liu, John Rong
Affiliation: UT MD Anderson Cancer Center
Abstract Preview: Purpose: We aimed to understand the physical performance of a CdTe PCD-based detector system within a whole-body PCD-CT scanner, with the goal of optimizing its clinical application. Instead of relyin...
Authors: Chao Guo, Xinhua Li, Michael F. McNitt-Gray, Di Zhang, Yifang (Jimmy) Zhou
Affiliation: UCLA, David Geffen School of Medicine at UCLA, Cedars-Sinai Medical Center
Abstract Preview: Purpose: The objective was to quantify the liver fat volume fraction (FVF) with virtual monochromatic imaging (VMI) using photon-counting CT (PCCT) and dual energy CT (DECT).
Methods: A custom desi...
Authors: Carina Gassner, Guyue Hu, Thomas Kröncke, Christopher Kurz, Guillaume Landry, Katharina Niepel, Katia Parodi, Franka Risch, Florian Schwarz
Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Diagnostic and Interventional Radiology, University Hospital Augsburg, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) München, Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU Munich)
Abstract Preview: Purpose: To evaluate the performance of a clinical photon-counting CT (PCCT) scanner in terms of proton relative stopping power (RSP) estimation using PCCT data and to compare the impact of different ...
Authors: Lizbeth Ayala-Dominguez, Aaron L Carrel, Diego Hernando, Gabrielle L Hoffmann, Amber Possell, Ivan M. Rosado-Mendez, Jiayi Tang, Andrew Wentland
Affiliation: Department of Pediatrics, University of Wisconsin-Madison, Department of Radiology, University of Wisconsin-Madison, Department of Medical Physics, University of Wisconsin-Madison, Departments of Medical Physics and Radiology, University of Wisconsin-Madison
Abstract Preview: Purpose: Metabolic dysfunction-associated steatotic liver disease (MAFLD) is the leading cause of chronic liver disease in children. While biopsy remains the diagnostic standard, non-invasive imaging ...
Authors: Kuan Ling Chen, Jiajin Fan, Rao Khan, Robabeh Rahimi
Affiliation: University of Maryland, Inova Schar Cancer Institute, Howard University
Abstract Preview: Purpose: This study evaluates the dose response, energy dependency, sensitivity, reproducibility, temporal response, and LET dependency along and in the plane perpendicular to a clinical proton beam f...
Authors: Anahita Bakhtiari Moghaddam, Don F. DeJongh, Ethan DeJongh, Jennifer Hardt, Oliver Jäkel, Lukas Martin, Alexander Pryanichnikov, Joao Seco, Christina Stengl, Niklas Wahl
Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Division of Biomedical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), ProtonVDA LLC, Department of Physics and Astronomy, Heidelberg University, Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT)
Abstract Preview: Purpose:
To evaluate the feasibility and performance of single-plane position tracking for proton and helium pencil beam radiography using a prototype imaging system, with the goal of providing a c...
Authors: Muhammad Ramish Ashraf, Dixin Chen, Aaron Garza, Lloyd Emmanuel Kamole Ghomsi, Edward Elliot Graves, Billy W Loo, Stavros Melemenidis, Joseph B. Schulz, Lawrie Skinner, Murat Surucu
Affiliation: Department of Radiation Oncology, Department of Radiation Oncology, Stanford University School of Medicine
Abstract Preview: Purpose: FLASH radiotherapy, supported by robust preclinical evidence showing an improved therapeutic index, is advancing toward clinical trials. Clinical FLASH treatments will likely require scanning...
Authors: Azza Mohamed Ahmed, Nadine Francis, Osama Khan, Nabil Maalej, Aamir Raja, Briya Tariq
Affiliation: Khalifa University
Abstract Preview: Purpose: The study aims to evaluate the task-specific diagnostic performance of spectral photon-counting CT (SPCCT) using application-specific phantoms.
Methods:
Parameters such as linearity res...
Authors: Xiangli Cui, Wanli Huo, Jie Li, Lingling Liu, Tao Ma, Yuanyuan Wang
Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Ion Medical Center, Hefei Cancer Hospital, Chinese Academy of Sciences, the Zhejiang-New Zealand Joint Vision-Based Intelligent Metrology Laboratory, College of Information Engineering, China Jiliang University
Abstract Preview: Purpose: In practice, treatment planning systems (TPS) of proton therapy require a CT calibration curve, which relates Hounsfield units (HU) to relative stopping power (RSP). Single-energy CT as a sta...
Authors: Zijia Guo, Viktor Haase, Michael F. McNitt-Gray, Frederic Noo
Affiliation: Siemens Healthineers, University of Utah, David Geffen School of Medicine at UCLA
Abstract Preview: Purpose: The attenuation values in CT hold strong potential for disease diagnosis. However, they lack reliability, which has limited their use to clinical trials where variability can be controlled. S...
Authors: Ozgur Ates, Chin-Cheng Chen, Chia-Ho Hua, Matthew J. Krasin, Thomas E. Merchant
Affiliation: St. Jude Children's Research Hospital
Abstract Preview: Purpose: To validate the use of synthetic CTs generated from CBCT images for online monitoring, ensuring accurate and reliable daily plan quality assessments in adaptive proton therapy (APT).
Metho...
Authors: Cambridge L Bui-Nguyen, Alexander S. Nguyen, Liqiang (Lee) Tao
Affiliation: Varian AOS @Epic Care, UC Berkeley
Abstract Preview: Purpose: To quantity variations in Winston Lutz (WL) test results due to different energies used in SBRT, SRT or SRS.
Methods: A WL phantom with a 6.4 mm diameter center radio-opaque sphere is used...
Authors: Harold Y Hu, Yanle Hu, Shuai Leng, Maryam Sadeghian, Joe Swicklik
Affiliation: Mayo Clinic Arizona, Basis Scottsdale, Mayo Clinic
Abstract Preview: Purpose: Radiotherapy CT simulation often requires two scans: a non-contrast scan for dose calculation and a contrast-enhanced scan for target delineation. Photon-counting-detector (PCD) CT allows the...