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Results for "normal tissue": 106 found

A Dosimetric Investigation into the Potential of Aperture-Based Techniques to Improve the Clinical Outcomes of Single-Energy Proton Bragg Peak Flash Therapy for Ocular Cancers

Authors: Arpit M. Chhabra, J Isabelle Choi, Minglei Kang, Haibo Lin, Hang Qi, Charles B. Simone, Shouyi Wei, Irini Yacoub, Francis Yu, Xingyi Zhao, Ajay Zheng

Affiliation: New York Proton Center, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Pencil beam scanning (PBS) proton therapy effectively treats ocular cancer by minimizing exit doses to normal tissues. However, challenges remain in sparing nearby organs-at-risk(OARs). Ul...

A Dosimetric Study of Small-Field Apertured Spot-Scanning Proton Stereotactic Radiosurgery for Pediatric Brain Tumors

Authors: Chin-Cheng Chen, Chia-Ho Hua, Christopher J. Kutyreff, Thomas E. Merchant

Affiliation: St. Jude Children's Research Hospital

Abstract Preview: Purpose: A dosimetric study was conducted to determine the optimal field parameters for a commercially available small-field applicator (SFA) used in spot-scanning proton stereotactic radiosurgery, pa...

A Modified VMAT Technique for the Treatment of Diffuse and Extensive Involvement of the Skull By Various Malignancies

Authors: Edward D. Brandner, Weihua Fu, M. Saiful Huq, Ronald John Lalonde, Kiran Mehta, Hima Bindu Musunuru, Yongqian Zhang

Affiliation: UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, University of Pittsburgh School of Medicine and UPMC Hillman CancerCenter

Abstract Preview: Purpose: Treatment of diffuse and extensive involvement of the skull by malignancy presents a difficult challenge for radiation therapy. This study reports preliminary experience of a modified volumet...

A Novel Semi-Analytic Approach for Dose Calculation in Proton Minibeam Radiotherapy

Authors: Hao Gao, Wangyao Li, Yuting Lin, Chao Wang, Wei Wu

Affiliation: Institute of Modern Physics, Chinese Academy of Sciences, Department of Radiation Oncology, University of Kansas Medical Center

Abstract Preview: Purpose: Proton minibeam radiation therapy (pMBRT) delivers a unique peak-and-valley dose pattern using collimators with narrow slits, offering improved normal tissue sparing compared to conventional ...

A Vqvae-Based Framework with Embedded Kullback-Leibler Divergence for Stochastic and Diverse Dose Prediction

Authors: Weigang Hu

Affiliation: Fudan University Shanghai Cancer Center

Abstract Preview: Purpose: The purpose of this study is to introduce a VQVAE-based framework that addresses the limitations of conventional dose prediction methods, which rely on fixed deep learning models that produce...

AI Auto-Contouring for CT-Based High-Dose-Rate Interstitial Brachytherapy of Cervical Cancer: Implications for Organ-at-Risk (OAR) Contouring and Dosimetric Analysis

Authors: Indrin J. Chetty, Jing Cui, Mitchell Kamrava, Tiffany M. Phillips, Jennifer M. Steers, Brad Stiehl

Affiliation: Department of Radiation Oncology,Cedars-Sinai Medical Center, Cedars-Sinai Medical Center

Abstract Preview: Purpose: Auto-contouring for HDR interstitial brachytherapy can be confounded by large deformation in anatomy and image quality. Here we evaluated the performance of an AI-based auto-contouring softwa...

Advancing Flash Radiotherapy: Intercomparison of Parameters between Two Institutions to Optimize Clinical Applications.

Authors: Amir Abdollahi, Celine Karle, Michele M. Kim, Constantinos Koumenis, Andrea Mairani, Erato Stylianou Markidou

Affiliation: Heidelberg Ion-Beam Therapy Center - Department of Radiation Oncology, German Cancer Research Centre(DKFZ), University of Pennsylvania, Physics Dep. University of Cyprus

Abstract Preview: Purpose: The aim is to compare FLASH dose-rate RT generated with protons and carbon (HIT) and compare to protons (UPenn) to provide evidence for equipotency of FLASH vs. standard RT to tumor growth co...

An Energy Layer Optimization Approach for Spot Scanning Proton Arc Therapy

Authors: Wenhua Cao, Hadis Moazami Goudarzi, Madison Emily Grayson, Zongsheng Hu, Gino Lim, Steven Hsesheng Lin, Radhe Mohan

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Industrial Engineering, University of Houston, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Proton Arc Therapy (PAT) offers significant potential in treating complex cancer cases by delivering a continuous radiation dose as the gantry rotates. This study aims to investigate the pote...

Analytical Approach to Calculate Normal Tissue Complication Probability and Tumor Control Probability for Ultra-High Dose Rate Radiation (FLASH) Based on Linear-Quadratic Model

Authors: Santosh K. Agarwalla, Nrusingh C. Biswal, Shree C, Harikrishnan Suresh Kumar, Jajati K. Nayak, Prema P., Sarath K S, Tamil Selvan S, Hem D. Shukla

Affiliation: Variable Energy Cyclotron Centre, Department of Physics, Fakir Mohan University, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Sciences, Amrita Vishwa Vidyapeetham

Abstract Preview: Purpose: The rapid oxygen depletion in tissues during irradiation is the most accepted mechanism of the FLASH effect. However, the Normal Tissue Complication Probability (NTCP) and Tumor Control Proba...

Analyzer-Less X-Ray Interferometry with Super-Resolution Methods

Authors: Joyoni Dey, Hunter Cole Meyer, Murtuza Taqi

Affiliation: Louisiana State University

Abstract Preview: Purpose: We propose using super-resolution methods for X-ray grating interferometry without an analyzer with detectors that fail to meet the Nyquist sampling rate needed for traditional image recovery...

Assessing the Impact of Intrafraction Shifts on Critical OAR Doses in a Standardized Spine SBRT Program

Authors: Daniel A. Alexander, Anish Butala, Anthony Austin Kassaee, Neil Malhotra, Ian Messing, Gabrielle W Peters, Ryan M. Scheuermann

Affiliation: Department of Radiation Oncology and Applied Sciences, University of Pennsylvania

Abstract Preview: Purpose: Stereotactic Body Radiation Therapy (SBRT) for spinal metastases uses CBCT-based localization and highly conformal treatment delivery to increase the biologically equivalent dose to the targe...

BEST IN PHYSICS MULTI-DISCIPLINARY: Building a Cross-Modality Model to Integrate Bio-Clinical Features, Anatomical MRI, and White-Matter Pathlength Mapping for Personalized Glioblastoma RT Planning

Authors: Steve Braunstein, Angela Jakary, Hui Lin, Bo Liu, Janine Lupo, Tiffany Ngan, Ke Sheng, Nate Tran

Affiliation: Radiation Oncology, University of California San Francisco, Graduate Program in Bioengineering, University of California San Francisco-UC Berkeley, Department of Radiation Oncology, University of California San Francisco, Department of Radiology and Biomedical Imaging, University of California San Francisco, Department of Radiation Oncology, University of California, San Francisco

Abstract Preview: Purpose: Current RT clinical target volumes (CTVs) for Glioblastoma (GBM) employ 2cm isotropic expansions of gross tumor volumes. However, studies showed patients still experience progression beyond t...

BEST IN PHYSICS THERAPY: Impact of Local Tissue Oxygenation Level on the Flash Effect in Murine Skin

Authors: David J. Gladstone, P. Jack Hoopes, David I Hunter, Brian W Pogue, Jacob Pierce Sunnerberg, Armin Tavakkoli

Affiliation: Thayer School of Engineering, Dartmouth College, University of Wisconsin - Madison, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Geisel School of Medicine, Dartmouth College

Abstract Preview: Purpose: The FLASH effect, characterized by normal tissue sparing under ultra-high dose rate (UHDR) radiation delivery, remains mechanistically unclear. This study investigated the relationship betwee...

Benefits on Respiratory Gating Delivery of Lung SBRT

Authors: Andrew Huang, Jonathan Huang, Andrew S Kennedy, Ellie Grace Kong, Ajay Zheng

Affiliation: New York Proton Center, Centennial Medical Center, Executive Medical Physics Associates, Sarah Cannon Cancer Institute, Belmont University

Abstract Preview: Purpose:
Lung stereotactic body radiotherapy (SBRT) is the standard of care for early-stage lung cancer. Respiratory phase gating can be applied to mitigate motion-induced effects. The purpose of t...

Biomarkers Beyond the GTV: Normal Tissue Imaging Biomarkers for In Vivo Applications

Authors: Tokihiro Yamamoto

Affiliation: UC Davis School of Medicine

Abstract Preview: N/A...

Characterization of Linear Energy Transfer Spectra in Mini Beam Spatially Fractionated Proton Therapy

Authors: Serdar Charyyev, Kaan Dere, Edgar Gelover, Mohammad Khurram Khan, Liyong Lin, Mark McDonald, Cristina Oancea, Alexander Stanforth, Sibo Tian, Suk Whan (Paul) Yoon, Mingyao Zhu

Affiliation: Department of Radiation Oncology, Stanford University, Stanford University, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Advacam

Abstract Preview: Purpose: The conventional implementation of proton spatially fractionated radiotherapy (SFRT) utilizes physical collimators with apertures to generate minibeams, creating alternating regions of high-d...

Clinical Trial Reporting, Reproducibility, and Standardization: Consistency for Implementation.

Authors: Stella Flampouri, Heng Li, Sarah Quirk, Timothy Ritter, Mihaela Rosu-Bubulac, Toni M. Roth, Michael B. Roumeliotis, Koren Smith, Wade P. Smith

Affiliation: Johns Hopkins University, Virginia Commonwealth University, University of Washington, VCU Health System, UMass Chan Medical School/IROC RI, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Emory University, Brigham and Women's Hospital; Harvard Medical School, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: To assess clinical trial reproducibility for translation to standard clinical care in radiation therapy.
Methods: The systematic review adheres to the Preferred Reported Items for Systemat...

Cloud Workflow AI Apps for Radiotherapy Image Analysis Using Pycerr and Seven Bridges-Cancer Genomics Cloud

Authors: Aditya P. Apte, Joseph O. Deasy, Sharif F. Elguindi, Aditi Iyer, Jue Jiang, Eve Marie LoCastro, Jung Hun Oh, Amita Shukla-Dave, Harini Veeraraghavan

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: We present publicly shareable applications (apps) for AI-based radiotherapy segmentation workflows with pyCERR on Seven Bridges Cancer Genomics Cloud-based platform (CGC-SB)
Methods: Runni...

Combining Proton Flash and Spatially Fractionated Radiotherapy – Experimental and Simulation Based Dosimetric Characterization

Authors: Gulakhshan M Hamad, Sina Mossahebi, Yannick P. Poirier, Amit Sawant

Affiliation: University of Maryland School of Medicine, Maryland University Baltimore

Abstract Preview: Purpose:
The combination of ultra-high dose rate (UHDR) proton therapy, known for normal tissue sparing, with spatially-fractionated radiotherapy (SFRT), promising enhanced tumor control and tissue...

Comparison of Dose Metrics to Critical Heart Substructures for Different Planning Techniques, and Scan Techniques for Right Sided Breast Irradiation

Authors: Wesley A. Belcher, Aidan Burke, Matthew Green, Taylor Stamey

Affiliation: ECU Health, East Carolina University Brody School of Medicine

Abstract Preview: Purpose: The purpose of this study was to determine the effect of using deep inhalation breath hold (DIBH) vs. free breathing (FB) and intensity-modulated radiation therapy (IMRT) vs. 3D for right-sid...

Consecutive Daily Fractions with Itv Boost Are Safe for Treating Central Non-Small Cell Lung Cancer Using Stereotactic Body Radiation.

Authors: Baher Elgohari, M. Saiful Huq, Ronald John Lalonde, Fang Li, Noor Mail, Jeonghoon Park, Tyler Wilhite

Affiliation: UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, Department of Radiation Oncology, UPMC Hillman Cancer Center, UPMC, Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose:
To compare toxicity between consecutive-daily (QD) with every-other-day (QoD) delivery of lung stereotactic-body-radiation (SBRT) for central non-small-cell lung cancer (NSCLC).
Methods...

Developing and Using Barcode-Reading Type Portable OCT Imaging System to Detect Surgical Margin

Authors: Dukagjin Blakaj, Zhilin Hu, Stephen Kang, Abberly Lott Limbach, Lanchun Lu, Henry Xiang, Jie Zhang

Affiliation: Pharostek, Department of Pediatrics, The Ohio State University, Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Department of Radiology, University of Kentucky, Department of Pathology, The Ohio State University, Department of Radiation Oncology, The Ohio State University, Department of Otolaryngology, The Ohio State University

Abstract Preview: Purpose: Detect surgical margin in vivo using an original barcode-reading type portable OCT imaging system.
Methods: We developed a barcode-reading type portable optical coherence tomography (OCT) ...

Development of Hybrid Shielding Collimator to Reduce Radiation Exposure in Fluoroscopy

Authors: Yona Choi, Kyo-tai Kim, Seungwoo Park, Dung Thi Tran

Affiliation: Gemss Health Care Inc,, Korea Institute of Radiological & Medical Sciences

Abstract Preview: Purpose: We developed shielding materials and a hybrid concept collimator for fluoroscopy to reduce the dose to normal tissues outside the treatment field, which are capable of quantifying dose rate a...

Development of Preclinical Multiscale Dosimetry for Beta-Particle Emitting Radionuclide in Radiopharmaceutical Therapy

Authors: Adedamola Adeniyi, Bryan Bednarz, Malick Bio Idrissou, Reinier Hernandez, Ohyun Kwon, Brian W. Miller, Zachary S Morris, Maya Takashima, Jamey Weichert

Affiliation: Departments of Radiation Oncology and Medical Imaging, University of Arizona, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Radiology, School of Medicine and Public Health, University of Wisconsin–Madison, Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin–Madison

Abstract Preview: Purpose: As radiopharmaceutical therapy (RPT) becomes more prevalent in clinical applications, understanding dose-response relationships in the tumor microenvironment (TME) and normal tissues is essen...

Development of a Computational Immunohistochemical Stained Tissue Analysis of Intracellular Flash Induced Radiochemical Oxygen Depletion

Authors: Najah Curtis, Michele M. Kim, Cameron Koch, Ioannis I Verginadis, Rodney D. Wiersma, Jennifer Wei Zou

Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania, UCLA

Abstract Preview: Purpose: FLASH has been shown to have increased normal tissue sparing compared to standard dose rate radiation and, separately, has been shown to rapidly consume oxygen intercellularly in vivo through...

Differential Gastrointestinal Responses to Synchrotron-Produced Proton and Electron Irradiation Under Flash and Conventional Conditions

Authors: Luke Connell, Nolan M. Esplen, Elise Konradsson, Albert C. Koong, Ziyi Li, Steven Hsesheng Lin, Kevin Liu, Billy W Loo, Devarati Mitra, Radhe Mohan, Emil Schueler, Takeshi Takaoka, Uwe Titt, Xiaochun Wang, Ming Yang

Affiliation: The University of Texas MD Anderson Cancer Center, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Stanford University School of Medicine

Abstract Preview: Purpose: This study aimed to assess radiation-induced gastrointestinal (GI) toxicity in mice subjected to abdominal irradiation using protons at ultra-high-dose-rate (UHDR) and conventional dose-rates...

Differential Hole-Size Lattice Patterns for Escalating SFRT Dose to Large, Deep-Seated, and Unresectable Masses

Authors: Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine

Abstract Preview: Purpose: Development of a novel spatially fractionated radiotherapy (SFRT) lattice deployment method featuring a large high-dose sphere at the tumor’s center, surrounded by smaller diameter spheres. W...

Dosimetric Analysis of Lymphopenia after Lung Irradiation and Modeling the Probability of Normal Tissue Complications

Authors: Tianyuan Dai, Xiaoying Fan, Shuting Wang, Yong Yin

Affiliation: Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

Abstract Preview: Purpose: Decreased lymphocytes increase the risk of infections and other problems. Radiation exposure can cause the development of severe lymphopenia. In this study, we used a dynamic blood flow model...

Dosimetric Analysis of Plans Using X-Ray and X-Îł-Ray Combination Strategy for Advanced Cervical Cancer Patients with Pelvic Lymph Node Metastasis

Authors: Yi Li

Affiliation: Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University

Abstract Preview: Purpose: Advances in radiotherapy technology are crucial for improving cervical cancer (CC) treatment. This study explores a novel X-ray and Îł-ray dual-modality radiation (TaiChiB) system, comparing i...

Dosimetric Assessment of Simultaneous Multi-Energy and Fluence Optimization for IMRT and VMAT

Authors: Aliasghar Rohani, Rui Zhang

Affiliation: Louisiana State University, Baton Rouge, Louisiana, Department of Radiation Oncology, Mary Bird Perkins Cancer Center

Abstract Preview: Purpose: This study aimed to evaluate the impact of simultaneous optimization of multi-photon beam energy and fluence on IMRT and VMAT treatment planning.
Methods: An Elekta linear accelerator (lin...

Dosimetric Characterization of Spatial Fractionation Collimator for Ultra-High Dose Rate Electron Beam

Authors: Lily Jo Bertemes, Careesa Billante, Ashley Cetnar, Arnab Chakravarti, Nilendu Gupta, Sagarika Jain, Maximilian Stephen Meineke, Allison N. Palmiero, Runhe Tan

Affiliation: The Ohio State University - James Cancer Hospital, Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center, The Ohio State University, The James Cancer Center

Abstract Preview: Purpose: Ultra-High Dose Rate Radiation Therapy (UHDR-RT) induces normal tissue sparing while maintaining iso-effective tumor control compared to conventional methods, known as the “FLASH effect”. How...

Effect of Variation in the ι/β of Cervical Cancer on Clinical Outcomes of Radiation Therapy

Authors: Dennis A. Cheek, Wei Luo, Cameron Thayer-Freeman, Brien Timothy Washington

Affiliation: UT Southwestern Medical Center, University of Kentucky, Department of Radiation Medicine, University of Kentucky

Abstract Preview: Purpose: To investigate the effect of variation in the ι/β of cervical cancer on clinical outcome for cervix cancer patients treated with radiation therapy.
Methods: A distribution of experimentall...

Enhanced Lung Function Assessment through Machine Learning Analysis of 4DCT Subregional Respiratory Dynamics

Authors: Jing Cai, Zhi Chen, Hong Ge, Yu-Hua Huang, Bing Li, Zihan Li, Ge Ren

Affiliation: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital

Abstract Preview: Purpose: Algorithms based on subregional respiratory dynamics (SRD) capture spatiotemporal heterogeneity in the ventilation process, though rely on empirical modelings to map surrogate ventilation. Gi...

Establishing Energy Thresholds for Targeted Cherenkov Light Photoactivation

Authors: David Alcorta, Lindsay Bolino, Olivia Canter, Seifallah Emam, Joseph Farina, Timothy Haystead, Philip Hughes, Keshav Jha, David Loiselle, Mark Oldham, Victoria J. P. Radosova

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke Univerity, Department of Radiation Oncology, Duke University Medical Center

Abstract Preview: Purpose: To simulate how Cherenkov light (CL) produced during radiation therapy can activate targeted photodynamic molecules. To experimentally determine dose and concentration thresholds for biologic...

Establishing a Conventional Linac-Based Electron Flash Beam

Authors: Christopher Bartee, Justin Riley DeFrancisco, Marcos Feijoo, Siyong Kim, Tianjun Ma

Affiliation: Blue Physics LLC, Virginia Commonwealth University

Abstract Preview: Purpose: Irradiation with FLASH has been shown to decrease normal tissue toxicity while maintaining similar tumor control. To advance FLASH into the clinic, more preclinical investigations are first n...

Evaluating Normal Tissue Toxicity Following Pulsed Low Dose Rate Radiotherapy

Authors: Shahabeddin mostafanazhad Aslmarand, Lili Chen, Dusica Cvetkovic, Troy A. Dos Santos, Chang Ming Charlie Ma, Dae-Myoung Yang

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose:
Pulsed low-dose-rate radiotherapy (PLDR) has been proposed to reduce normal tissue toxicity while maintaining tumor control comparable to conventional radiotherapy (CRT). This study assess...

Evaluating Three Practical Approaches to Managing Dose Accumulation in Normal Tissues during Radiation Re-Treatments

Authors: Derek A. Fiedler, Nixon Gutierrez, Quyen L. Jones, Zejian Liu, Tatsiana Reynolds

Affiliation: Texas Oncology, Minnesota Oncology, US Oncology

Abstract Preview: Purpose: Optimize patient safety and treatment efficacy during radiation re-treatment planning. Provide a comprehensive comparison of the methods by focusing on their applicability, accuracy, and limi...

Evaluating the Impact of Beam Spot Spacing on Dose Rates and Field Uniformity for Small Animal Proton Ultra-High Dose Rate Irradiation

Authors: Jack Biondo, Audrey Magness, Anthony E. Mascia, Zhiyan Xiao, Yongbin Zhang

Affiliation: Cincinnati Children's Proton Therapy Center

Abstract Preview: Purpose: Proton FLASH-RT has shown promise reducing normal tissue toxicity while maintaining tumor control. However, in vivo experiments critically depend on achieving ultra-high dose rate (UHDR) and ...

Evaluating the Performance and Limitations of an Automated Treatment Planning Tool for Intact Breast Radiotherapy across Diverse Patient Populations

Authors: Shatha Al Afifi, Hana Baroudi, Leonard Che Fru, Laurence Edward Court, Suzanne B. Evans, Kent A. Gifford, Adam D. Melancon, Melissa P. Mitchell, Issa Mohamad, Patricia Murina, Manickam Muruganandham, Tucker J. Netherton, Callistus M. Nguyen, Joshua S. Niedzielski, Deborah L. Schofield, Simona Shaitelman, Willie Shaw, Sanjay S. Shete, Adam Shulman, Brendon Smith, Sheeba Thengumpallil, Carlos Daniel Venencia, Conny Vrieling

Affiliation: University of Cape Town, MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center, University of the Free State, UT MD Anderson Cancer Center, King Hussein Cancer Center, Instituto Zunino - Fundacion Marie Curie, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Dra., Hirslanden Clinique des Grangettes, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Department of Therapeutic Radiology, Yale University School of Medicine, Yale University, The University of Texas, MD Anderson, Houston TX

Abstract Preview: Purpose:
Automated contouring and planning tools are usually trained on single-institution datasets, seldom tested across diverse patient populations. This introduces a risk of population bias, res...

Evaluation of Daily Respiratory Pattern from a Single Free-Breathing Cone Beam CT Scan

Authors: Weixing Cai, Laura I. Cervino, Yabo Fu, Xiuxiu He, Tianfang Li, Xiang Li, Hao Zhang

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose:
This work aims to develop an innovative technique to evaluate patients’ daily respiratory pattern using three-dimensional (3D) deformation vector fields (DVF) derived from a free-breathing...

Evaluation of Proton Therapy Robustness for Thoracic Cancer Patients

Authors: Lordina Owusuwaa Oheneferewoo Asibey, Rachel B. Ger, Heng Li

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University, Howard University

Abstract Preview: Purpose: Treatment of cancer patients with proton therapy requires robust optimization applications to be able to provide adequate target coverage whiles sparing healthy tissues. Our goal was to evalu...

Evaluation of a Commercial Metal Artifact Reduction Algorithm for IGRT in Patients with Hip Prostheses

Authors: Laura Bennett, Matthew Charles, Greg Cooley, John M. Floberg, Ryan Hutten, Elissa Khoudary, Nicholas Lynch, Kaili Ranta, Jordan M. Slagowski, Trevor Wilson

Affiliation: University of Pennsylvania, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, University of Wisconsin-Madison, University of Wisconsin-Madison

Abstract Preview: Purpose: To evaluate the impact of an iterative cone beam CT with metal artifact reduction (iCBCT+MAR) reconstruction algorithm (HyperSight TrueBeam 4.1, Varian Medical Systems) on image quality and s...

Explaining the Normal Tissue Sparing of Flash By Oxygen Fixation Hypothesis

Authors: Daisuke Kawahara, Yoichi Watanabe

Affiliation: Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Radiation Oncology, University of Minnesota Medical School

Abstract Preview: Purpose: To theoretically demonstrate that FLASH dose delivery leads to higher normal tissue sparing than conventional dose rates.
Methods: A two-component kinetic model was built for target and da...

First in-Vivo Application of a Novel Precision Small Animal Irradiation Platform with Proton IMPT Delivery and Advanced on-Board Image-Guidance

Authors: Niels Bassler, Jonathan Bortfeldt, Davide Boscaini, Francesco Evangelista, Guyue Hu, Ze Huang, Margarita Kozak, Julie Lascaud, Giulio Lovatti, Eero LÜnnqvist, Jasper Nijkamp, Munetaka Nitta, Prasannakumar Palaniappan, Katia Parodi, Marco Pinto, Per R. Poulsen, Marco Riboldi, Babak Sharifi, Brita Singers Sørensen, Peter Thirolf

Affiliation: Department of Medical Physics, Ludwig-Maximilians-Universität Mßnchen (LMU Munich), Ludwig-Maximilians Universität, Danish Centre for Particle Therapy, Aarhus University Hospital, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen, Department of Experimental Clinical Oncology, Aarhus University, Department of Oncology, Aarhus University Hospital

Abstract Preview: Purpose: To perform the first in vivo application of a novel small animal radiation research platform combining on-board image-guidance with multi-field intensity modulated spot scanning delivery [1] ...

Free Radical Irradiation Emergent (FIRE) MRI: Real-Time MR-Based Quantification of Radiation-Produced Free Radical Generation on a Clinical MR-Linac

Authors: Claire Keun Sun Park, Atchar Sudhyadhom, Veena Venkatachalam, Noah Warner

Affiliation: Harvard–MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School,, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School

Abstract Preview: Purpose: Modern radiotherapy achieves sub-millimeter spatial accuracy but fails to account for patient- and spatially-specific variations in biological response. Free radical generation (FRG), particu...

From Supine to Upright: A Geometric Shift in Perspective

Authors: Ben Durkee, Renata Farrell, Carri K. Glide-Hurst, Colin Harari, Alex Singleton Kuo, Chase Ruff, Jordan M. Slagowski, Yuhao Yan

Affiliation: University of Wisconsin, Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: Advances in upright CT and patient positioning system now enables high quality daily CT imaging and treatment delivery in the upright position, providing benefits including reduced internal m...

Functional MRI Guided Partial Tumor Irradiation to Improve Tumor Control and Spare Tumor Microenvironment

Authors: Bingqi Guo, Ping Xia

Affiliation: Cleveland Clinic

Abstract Preview: Purpose:
Spatially fractionated radiation therapy (SFRT) delivers a “GRID” or “lattice” of high and low doses to tumors to increase tumor control, minimize normal tissue damage, and preserve the im...

Generalizable 7T T1 Map Synthesis from 1.5T and 3T T1W MRI for High-Resolution MRI-Guided Radiation Therapy

Authors: Zachary Buchwald, Chih-Wei Chang, Zach Eidex, Hui Mao, Richard L.J. Qiu, Justin R. Roper, Mojtaba Safari, Hui-Kuo Shu, Xiaofeng Yang, David Yu

Affiliation: Emory University and Winship Cancer Institute, Emory University, Department of Radiation Oncology and Winship Cancer Institute, Emory University, Emory University School of Medicine

Abstract Preview: Purpose: MRI-guided radiation therapy (MRgRT) benefits significantly from enhanced soft-tissue contrast and spatial resolution, which aid in accurately delineating tumors and organs at risk. Although ...

HypersightÂŽ Offline Adaptive Workflow

Authors: Doris Dimitriadis/Dimitriadou, Denisa R. Goia, M. Saiful Huq, Ronald John Lalonde, Noor Mail, Adam Olson, Tyler Wilhite

Affiliation: UPMC Hillman Cancer Center, UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine, UPMC

Abstract Preview: Purpose: The goal of the HyperSightÂŽ offline adaptive-workflow is to create a methodical approach to adaptive-radiotherapy (ART) that considers modifications in patient setup and anatomy. Through effi...

Imaging Preclinical Proton Flash Radiation Using a Small Animal PET System

Authors: Xun Jia, Heng Li, Wen Li, Devin Miles, Daniel Sforza, Lingshu Yin, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: FLASH therapy holds great potential to revolutionize radiotherapy by minimizing toxicities of normal tissues. The extraordinarily high dose rate of FLASH proton beam makes precise delivery to...

Impac of Respiratory Motion on Dosimetric and Biological Outcomes in Lung Cancer SIB-SBRT: A 4D Dose Calculation Approach

Authors: Xiangli Cui, Lingling Liu

Affiliation: Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Hefei Cancer Hospital, Chinese Academy of Sciences

Abstract Preview: Purpose:
Respiratory motion introduces substantial dose uncertainties in lung cancer radiotherapy, particularly affecting dose distribution in Simultaneous Integrated Boost-Stereotactic Body Radiot...

Impact of Physics Modeling on Monte Carlo Normal Tissue Dose Reconstructions for Passive Scattering Proton Therapy Patients

Authors: Caroline Esposito, Keith T Griffin, Jae Won Jung, Choonik Lee, Choonsik Lee, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock

Affiliation: East Carolina University, University of Michigan, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School

Abstract Preview: Purpose: The National Cancer Institute’s Pediatric Proton and Photon Therapy Comparison Cohort aims to collect and analyze data from cancer centers across the United States and Canada to quantify diff...

Impact of Proton Beam Arrangements on LETd and RBE in Organs at Risk for Nasopharyngeal Cancer

Authors: Mauricio Acosta, Zachary Fellows, Alonso N. Gutierrez, Noah S. Kalman, Kristen A. McConnell, Rob Rohe, Andrew J. Wroe, Sreenija A Yarlagadda

Affiliation: Miami Cancer Institute, Baptist Health South Florida

Abstract Preview: Purpose:
Beam selection is crucial in proton therapy to ensure optimal physical and biological dose conformity to the target while maximizing sparing of normal tissue. This work investigates the im...

Improvements from Monte Carlo Simulations over Pencil Beam Algorithms for Normal Tissue Dose Reconstruction in Proton Therapy Patients

Authors: Amy Berrington de Gonzalez, Keith T Griffin, Jae Won Jung, Cari M Kitahara, Choonik Lee, Choonsik Lee, Aimee L McNamara, Matthew Mille, Harald Paganetti, Sergio Morato Rafet, Jan PO Schuemann, Jungwook Shin, Torunn I Yock

Affiliation: University of Michigan, East Carolina University, Massachusetts General Hospital, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Massachusetts General Hospital and Harvard Medical School, Institute of Cancer Research

Abstract Preview: Purpose: Radiotherapy dose reconstruction enables retrospective epidemiological studies that connect late health effects to the organ-absorbed radiation doses received during treatment. Though clinica...

Improving TG-263 Target Name Compliance Using Locally-Hosted Large Language Models

Authors: Rex A. Cardan, Carlos E. Cardenas, Udbhav S. Ram

Affiliation: The University of Alabama at Birmingham, University of Alabama at Birmingham

Abstract Preview: Purpose: The AAPM TG-263 report provides nomenclature guidelines for target and normal tissue structures used in radiation oncology. Adherence to these guidelines is challenging for targets, as there ...

Influence of the α/ß Ratio on Dose Constraints in Radiotherapy of Prostate Cancer

Authors: Marwa Y. Abdel Tawwab, Amin E Amin, Abdullah M. ElSharif, Somaia Metwally Elsayed, Magdy M. Khalil

Affiliation: School of Applied Health Science, Badr University in Cairo (BUC), Cairo, Egypt, Medical Physics, Radiation Oncology Department, Faculty of Medicine, Ain Shams University, Medical Biophysics, Department of Physics, Faculty of Science, Helwan University

Abstract Preview: Purpose: Prostate cancer radiotherapy typically employs conventional fractionation schedules over approximately eight weeks. This study investigates the effect of variations in the ι/β ratio on dose c...

Initial Phantom Studies Towards Implementation of Sequential Dual Energy CBCT on an Adaptive Radiotherapy Linac Platform

Authors: James M. Balter, Alexander Moncion, Ikechi S Ozoemelam

Affiliation: University of Michigan

Abstract Preview: Purpose: Sequential dual-energy cone beam computed tomography (DE-CBCT) integrated with an online adaptive platform could potentially improve soft tissue visualization for more accurate anatomical del...

Integrating Radiomics and ADC Ratio for Multicenter Prostate Cancer Diagnosis: A Harmonized Machine Learning Approach

Authors: George Agrotis, Marios Myronakis, Dimitrios Samaras, Kyriaki Theodorou, Ioannis Tsougos, Vassilios Tzortzis, Maria Vakalopoulou, Alexandros Vamvakas, Aikaterini Vassiou, Marianna Vlychou

Affiliation: Medical Physics Department, Medical School, University of Thessaly, Department of Radiology, University of Thessaly, Netherland Cancer Institute, Department of Urology, University of Thessaly, CentraleSupelec, University Paris-Saclay

Abstract Preview: Purpose: Prostate cancer (PCa) diagnosis remains challenging due to discrepancies in Gleason Scoring (GS) and risks of overdiagnosis and underdiagnosis. Multiparametric MRI (mpMRI), including Apparent...

Inter-Fraction Monitoring of Brain Metastases Resection Cavities during Fractionated Stereotactic Radiosurgery on the 0.35 T MRI-Linac

Authors: Eyub Y. Akdemir, Gregory A Azzam, Rupesh Kotecha, Gregory J. Kubicek, Natalia Lutsik, Eric Mellon, Siamak P. Nejad-Davarani, Parag Parikh, Karen C. Snyder

Affiliation: Miami Cancer Institute, Baptist Health South Florida, Department of Radiation Oncology, University of Miami, Henry Ford Health

Abstract Preview: Purpose: Resection cavity volumes shrink gradually over time after surgical resection of brain metastases. Fractionated stereotactic radiosurgery (fSRS) is often delivered to the cavity to prevent rec...

Investigating in-Vivo Megavoltage Radiodynamic Therapy from 6 to 45MV Photon Beam Radiation Therapy with 5-Aminolevulinic Acid

Authors: Lili Chen, Dusica Cvetkovic, Chang Ming Charlie Ma, Dae-Myoung Yang

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose: 5-aminolevulinic acid (5-ALA)-mediated radiodynamic therapy (RDT) has been shown to be an effective treatment option using high-energy photon beams. RDT utilizes tumoricidal capabilities caus...

Investigating the Flash Effect: Uncovering Brain Sparing and Cognitive Preservation across Varying Dose Rates in Whole-Brain Irradiation of in-Vivo Mouse Models

Authors: Denise Dunn, Scott R. Floyd, Tyler V. Kay, Anna Lynnette-Price, Eric L. Martin, Stepan Mikhailov, Taylor Nguyen, Mark Oldham, Victoria J. P. Radosova, Zachary J. Reitman, Ramona Rodriguiz, Andrew Thompson, William Wetsel, Seth Wilcox, Ying Wu

Affiliation: Duke University Mouse Behavior Core, Department of Physics, Duke University, Medical Physics Graduate Program, Duke University, Duke University Medical Physics Program, Duke University, Duke University Mouse Behavioral and Neuroendocrine Analysis Core Facility, Department of Radiation Oncology, Duke University Medical Center

Abstract Preview: Purpose: FLASH radiation therapy (RT) shows promise for reducing normal tissue damage, though its mechanisms remain unclear. Using an in-vivo model with the High Intensity Gamma-ray Source (HIGS) lina...

Investigating the Radiation Chemistry of Flash Radiation Therapy through Electron Paramagnetic (EPR) Spectroscopy

Authors: Ramin Abolfath, Alexander Baikalov, Stefan Bartzsch, Nolan M. Esplen, Alan Eduardo Lopez Hernandez, Emil Schueler

Affiliation: MD Anderson Cancer Center, PI Experimental Medical Physics, Institute of Radiation Medicine (IRM), Helmholtz Munich, Germany, Howard University, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: FLASH radiation therapy (FLASH-RT) leverages ultra-high dose rates (UHDR) to spare normal tissue as compared to conventional (CONV)-RT while preserving tumor control; this is termed the FLASH...

Investigation of 5-Aminolevulinic Acid and Acridine Orange in Radiodynamic Therapy: An in Vitro Study

Authors: Lili Chen, Dusica Cvetkovic, Tristan K. Gaddis, Chang Ming Charlie Ma, Dae-Myoung Yang

Affiliation: Fox Chase Cancer Center

Abstract Preview: Purpose:
Recent studies have shown that combining photosensitizers with radiation therapy can enhance tumor control while reducing damage to normal tissues, a technique known as Radiodynamic Therap...

Key Tumor Volume Zones for Advancing the Radiomics-Based Distant Recurrence Prediction

Authors: Ryan Alden, Tithi Biswas, Kaushik Halder, Felix Maria-Joseph, Michael Mix, Rihan Podder, Tarun Kanti Podder

Affiliation: SUNY Upstate Medical University, IIT-Roorkee, University of Florida

Abstract Preview: Purpose: Radiomics feature-based model for predicting distant recurrence can potentially provide critical insight for clinical decision-making and assistance in treatment strategies. This study focuse...

Knowledge-Based Planning for Chest Wall with Lymph Nodes Irradiation VMAT

Authors: Nesrin Dogan, Panagiota Galanakou, Robert Kaderka

Affiliation: University of Miami, Sylvester Comprehensive Cancer Center, University of Miami Sylvester Comprehensive Cancer Center

Abstract Preview: Purpose:
To develop knowledge-based treatment planning (KBP) for volumetric modulated arc therapy (VMAT) in chest wall treatments with regional nodal involvement. Given the challenges posed due to ...

Lesion Detection in Contrast Enhanced Cone Beam Breast CT with a Photon Counting Detector: A Monte Carlo Study

Authors: Ahad Ollah Ezzati, Xiaoyu Hu, Xun Jia, Youfang Lai, Kai Yang, Yuncheng Zhong

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Massachusetts General Hospital, Johns Hopkins University

Abstract Preview: Purpose: Contrast-enhanced breast cone-beam computed tomography (bCBCT) provides high-resolution, 3D imaging of breast tissues with improved differentiation between normal and abnormal tissues. Curren...

Longitudinal Assessment of Normal Lung Radiosensitivity to Individualize Reirradiation

Authors: Smith Apisarnthanarax, Clemens Grassberger, John Kang, Yejin Kim, Justin Leu, Dominic A. Maes, Matthew J. Nyflot, Ramesh Rengan, Annemarie Shepherd, Jing Zeng

Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Department of Radiation Oncology, University of Washington, University of Washington, Department of Radiation Oncology, Fred Hutchinson Cancer Center, University of Washington, University of Washington and Fred Hutchinson Cancer Center

Abstract Preview: Purpose: Reirradiation (ReRT) is a rapidly growing clinical challenge driven by better systemic therapy and longer survival, though clear guidelines for ReRT are lacking. Fitting traditional normal ti...

Mechanistical Modeling of Radiation Response of Parotid in Head and Neck Cancer Radiotherapy

Authors: Rachel B. Ger, Xun Jia, Youfang Lai, Todd R. McNutt, Xingyi Zhao

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Radiotherapy (RT) plays an essential role for head and neck (HN) cancer treatment but often results in xerostomia due to salivary gland damage. It is important to mechanistically model the ra...

Minimizing Abscopal Effects in Normal Tissues with Flash-RT: Mechanisms of Action and Potential Clinical Applications

Authors: Liang Cui, Xingyu Lu, Hang Shang, LingHong Zhou

Affiliation: Southern Medical University

Abstract Preview: Purpose: This study examines how varying dose rates of radiotherapy impact normal tissues outside the target area and analyzes the protective effects and regulatory mechanisms of ultra-high dose rate ...

Modeling Alpha-Particle Dose from Diffusing Alpha-Emitters Radiation Therapy in Tissue with Inhomogeneous Diffusion

Authors: Lior Arazi, Gil'ad N. Cohen, Antonio L. Damato, Irene P. Zhang

Affiliation: Unit of Nuclear Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, NYU Grossman School of Medicine, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: Diffusing alpha-emitters Radiation Therapy (“Alpha DaRT”) is a promising new radiation therapy modality for treating bulky tumors. The dose delivered by Alpha-DaRT sources is dependent on the...

Monte Carlo Evaluation of Water-Equivalent Materials for Nanowire-Based Oslds in Flash Radiotherapy

Authors: James Chun Lam Chow, Harry E Ruda

Affiliation: University of Toronto, Princess Margaret Cancer Centre

Abstract Preview: Purpose: FLASH radiotherapy (FLASH-RT) with dose rate greater than 40 Gy/s, has demonstrated potential in reducing normal tissue toxicity while maintaining tumor control. However, accurate and reliabl...

Multi-Region Multiomic Features Improve Random Forest Toxicity Modeling of Radiation Pneumonitis

Authors: Laurence Edward Court, Alexandra Olivia Leone, Zhongxing Liao, Saurabh Shashikumar Nair, Joshua S. Niedzielski, Ramon Maurilio Salazar, Ting Xu

Affiliation: The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Radiation Pneumonitis (RP) predictive models often rely on clinical and DVH parameters, but multiomic features from CT imaging and 3D dose distributions from various regions could provide add...

Multi-Variat, Multi-Model, and Multi-Patient: From Pure Feasibility to Generalizability in Machine Learning Outcome Prediction Model-Based Treatment Plan Optimization

Authors: Martin Frank, Oliver Jäkel, Niklas Wahl

Affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Karlsruhe Institute of Technology (KIT)

Abstract Preview: Purpose: Machine learning (ML) models on normal tissue complication and tumor control probability ((N)TCP) exploiting e.g. dosiomic and radiomic features are playing an increasingly important role in ...

NTCP Modeling and Dose-Volume Correlations for Rectal Symptoms Following Prostate Cyberknife SBRT.

Authors: Nicholas Joseph Casteloes, Brian T Collins, Sean P Collins, Shiva K. Das, Panayiotis Mavroidis, Michael Repka, Simeng Suy

Affiliation: University of South Florida, University of North Carolina

Abstract Preview: Purpose: To correlate four rectal symptoms with the dose to rectum in patients, who received SBRT with Cyberknife for prostate cancer. Also, to fit those dosimetric and outcome data by using a normal ...

NTCP Modeling of Dose to Bladder and Urethra with Urinary Symptoms Following Prostate Cyberknife SBRT.

Authors: Nicholas Joseph Casteloes, Brian T Collins, Sean P Collins, Shiva K. Das, Panayiotis Mavroidis, Michael Repka, Simeng Suy

Affiliation: University of South Florida, University of North Carolina

Abstract Preview: Purpose: To correlate two urinary symptoms with dose to bladder and urethra in patients who received SBRT with Cyberknife. Also, to use a normal tissue complication (NTCP) model to fit the dosimetric ...

NTCP Modeling of Skin Systemic Sclerosis 12 Months Post Radiotherapy for Head & Neck Cancer

Authors: Gregory A Azzam, Danielle Cerbon, Laura Huang, Panayiotis Mavroidis, Diana Molinares, Stuart E Samuels, Sotirios Stathakis

Affiliation: Mary Bird Perkins Cancer Center, University of Miami Sylvester Comprehensive Cancer Center, Mount Vernan Rehabilitation Medicine Associates, Department of Radiation Oncology, University of Miami, University of North Carolina

Abstract Preview: Purpose: This study aims at performing a normal tissue complication probability (NTCP) modeling by fitting the doses to the skin, sternocleidomastoid (SCM) muscle and subcutaneous tissue (subcut) stru...

Normal Tissue Dosimetry during Intra-Cavitary HDR Brachytherapy

Authors: Palanisamy Karunanithi, Karthikeyan Perumal, Siva Subramanian Vadivel

Affiliation: Dr. Kamakshi Memorial Hospital

Abstract Preview: Purpose:
Recent advancements in high dose-rate (HDR) brachytherapy include the image guidance, new applicators, and dose calculation algorithms. Brachytherapy has steep dose gradient, hence relativ...

Normal Tissue Toxicities

Authors: Robert Francois Hobbs

Affiliation: Johns Hopkins University

Abstract Preview: N/A...

Optimizing Quality Assurance CT Frequency and Setup Uncertainty in Brain Proton Therapy Patients for Reduced Normal Tissue Dose

Authors: Rachel B. Ger, Heng Li, Anh Tran

Affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Johns Hopkins University

Abstract Preview: Purpose: Proton therapy patients undergo quality assurance CT scans (QACTs) during treatment to verify dosimetric accuracy and utilize robustness scenarios for setup and range uncertainties. For intra...

Parameterized Dosimetric Models of the Lumbar Vertebrae for Patient-Informed Active Marrow Dosimetry in Radiopharmaceutical Therapy

Authors: Wesley E. Bolch, Chansoo Choi, Robert Joseph Dawson, Michael Lassmann, Maikol Salas-Ramirez, Bangho Shin, Johannes Tran-Gia, Yitian Wang

Affiliation: Department of Nuclear Medicine, University Hospital WĂźrzburg, University of Florida

Abstract Preview: Purpose: Conduct a parameterized library of mesh-type skeletal models across the lumbar vertebrae. In radiopharmaceutical dosimetry, the hematopoietic active bone marrow is typically a dose-limiting n...

Photon-Counting CT for Estimation of Quantitative Information for Radiation Therapy Treatment Planning: Assessment of Scanning Conditions and Phantom Sizes

Authors: Carina Gassner, Guyue Hu, Thomas KrĂśncke, Christopher Kurz, Guillaume Landry, Katharina Niepel, Katia Parodi, Franka Risch, Florian Schwarz

Affiliation: Department of Radiation Oncology, LMU University Hospital, LMU Munich, Department of Diagnostic and Interventional Radiology, University Hospital Augsburg, Department of Medical Physics, Ludwig-Maximilians-Universität (LMU) Mßnchen, Department of Medical Physics, Ludwig-Maximilians-Universität Mßnchen (LMU Munich)

Abstract Preview: Purpose: To evaluate the performance of a clinical photon-counting CT (PCCT) scanner in terms of proton relative stopping power (RSP) estimation using PCCT data and to compare the impact of different ...

Plan Optimization Parameter Impact on Gamma Pass Rates

Authors: Parham Alaei, Timothy J Allen, Tomas Agustin Montenegro

Affiliation: University of Minnesota, Department of Radiation Oncology, University of Minnesota, Minneapolis

Abstract Preview: Purpose:
To assess possible relationships between treatment plan optimization parameters and gamma pass rates in quality assurance (QA) analysis of IMRT/VMAT plans.
Methods:
Plan optimization...

Planning Study of Spatially Fractionated Radiotherapy (SFRT) for Treating Recurrent Glioblastoma Multiforme (GBM)

Authors: Hyunuk Jung, Fiona Li, Brian Marples, Michael Milano, Sean M. Tanny, Dandan Zheng, Yuwei Zhou

Affiliation: Department of Radiation Oncology, University of Rochester, University of Rochester Medical Center, University of Rochester

Abstract Preview: Purpose:
Recurrent GBM remains one of the most challenging cancers, with limited treatment options. We investigated potential planning parameters of SFRT, a novel radiotherapy technique that delive...

Population Level Robustness Evaluation for Establishment of Benchmarks for Optimized Plans for Prostate Proton Therapy

Authors: Laura Buchanan, Samantha G. Hedrick, Stephen L. Mahan, Isabella Pfeiffer, Chester R. Ramsey, Taylor Ransom

Affiliation: Thompson Proton Center, University of Tennessee

Abstract Preview: Purpose: Proton pencil beam scanning can reduce normal tissue dose but is highly sensitive to setup, anatomical changes, and range variations. These uncertainties may compromise target coverage and or...

Post-Implant Dosimetry (PID) between 1D and 2D Cs-131 Seed Models for Post-Op Cavities in Recurrent GBM Patients

Authors: Cindy Pham, Anurag Sharma, John Starner, Ching-Ling Teng, Michael A. Trager, Gabriella Wernicke

Affiliation: Northwell, Northwell Health, Radiation Medicine, Northwell Health

Abstract Preview: Purpose: Precisely identifying orientation of implanted seeds on post-implant CTs is challenging. This research addresses the dosimetric uncertainties stemming from uncertainties in identifying seed o...

Preclinical Assessment of Novel Targeted Chelate-Based Radiopharmaceuticals for Aggressive Cancer Detection

Authors: David Alcorta, Joseph Farina, Timothy Haystead, Yiping He, Philip Hughes, David Loiselle, Marybeth Nedrud, Victoria J. P. Radosova, Jianpeng Yu

Affiliation: Duke University Department of Pharmacology and Cancer Biology, Medical Physics Graduate Program, Duke University, Duke University Department of Medicine, Duke University, Duke University Pharmacology and Cancer Biology, Duke University School of Medicine, Duke Cancer Institute

Abstract Preview: Purpose: Targeted radiopharmaceuticals have become of widespread interest in the scientific community given their ability to detect and treat metastatic disease. We aim to validate the use of novel ch...

Preclinical Dosimetric Evaluation for Small Animal Study to Investigate Normal Tissue-Sparing Effects in the Electron Ultra-High Dose-Rate (FLASH) Environment

Authors: Ashok Bhandari, Andrew Joseph Fanning, Kyle J. Gallagher, Brendan Graff, Christopher Jenkins, Kyuhak Oh, Ying Yan, Su-Min Zhou

Affiliation: University of Nebraska Medical Center

Abstract Preview: Purpose: This study aimed to design a robust experimental setup to ensure accurate dose delivery using ultra-high-dose-rate for small animal experiments by conducting dosimetric evaluations prior to a...

Prior-Model-Free Dynamic CBCT Reconstruction Via Combined Optical Surface and X-Ray Imaging

Authors: Hua-Chieh Shao, Guoping Xu, You Zhang, Tingliang Zhuang

Affiliation: Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, UT Southwestern Medical Center

Abstract Preview: Purpose:
Advancements in onboard X-ray hardware allow high-quality CBCT imaging with a short scan time (~6s for Varian HyperSight), enabling CBCT-based dose calculation and treatment planning. Howe...

Proton Pencil Beam Scanning Ultra-High Dose Rate 3D Lattice Radiotherapy: A Proof-of-Concept Flash Sfrt Study

Authors: Richard Bakst, Arpit M. Chhabra, J Isabelle Choi, Chanda Guha, Minglei Kang, Nancy Y Lee, Haibo Lin, Hang Qi, Charles B. Simone, Pingfang Tsai, Milo Vermeulen, Shouyi Wei, Xiaodong Wu, Lee Xu, Irini Yacoub, Xingyi Zhao, Ajay Zheng

Affiliation: University of Miami, Peking University, New York Proton Center, Montefiore Medical Center and Albert Einstein College of Medicine, icahn school of medicine at mount sinai, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose:
Three-dimensional lattice radiation therapy (3D-LRT) effectively achieves local tumor control with limited morbidity. Pencil beam scanning (PBS) proton therapy provides precise dose confor...

Python-Native Cerr for Cloud-Based Medical Image Analyses

Authors: Aditya P. Apte, Joseph O. Deasy, Sharif Elguindi, Aditi Iyer, Jue Jiang, Eve Marie LoCastro, Jung Hun Oh, Amita Shukla-Dave, Harini Veeraraghavan

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center

Abstract Preview: Purpose: We present port of popular Computational Environment for Radiological Research software platform to Python programming language to cater to cloud-based analyses.
Methods: The components of...

Radio-Acoustic Monitoring of Electron Flash Therapy In Vivo

Authors: Kristina Bjegovic, Luke Connell, Emil Schueler, Leshan Sun, Lucy Whitmore, Liangzhong Xiang

Affiliation: University of California, Irvine, MD Anderson, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: The use of FLASH-RT in the clinic would greatly reduce off-target radiation toxicity in normal tissues. However, due to the hypo-fractionated delivery of prescribed doses at FLASH dose rates,...

Radiobiological Modeling of Tumor Control and Normal Tissue Response Following Mlc-Based Sfrt to Extensive Breast and Chest Wall Tumors

Authors: Ramesh Boggula, Yash Somnay, Hualin Zhang

Affiliation: Radiation Oncology, Keck School of Medicine of USC, Wayne State University

Abstract Preview: Purpose: Spatially fractionated radiation therapy (SFRT) allows delivery of therapeutic doses to bulky tumors otherwise limited by dose-volume effects that threaten organ-at-risk tolerances. For negle...

Raman Spectroscopy Identifies Biomolecular Differences between Caucasian and African American Prostate Cancer Patients

Authors: Nrusingh C. Biswal, Manas R. Gartia, Maria Iftesum, Sanjit K. Roy, Gyana Ranjan Sahoo, Elnaz Sheikh, Hem D. Shukla, Madhur Srivastava

Affiliation: Department of Chemistry and Chemical Biology, Cornell University, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Mechanical and Industrial Engineering, Louisiana State University

Abstract Preview: Purpose: Prostate cancer incidence and mortality levels in African-American men are the highest among all ethnic groups. This points to the role of biological factors in driving disparate outcomes. He...

Realistic Modeling of Vasculature Flow and Oxygen Distribution in Normal Tissue and Glioblastoma

Authors: Yi Fan, Andrew Friberg, Costas Koumenis, Kevin Teo, Ioannis I Verginadis, Ledi Wang, Jennifer Wei Zou

Affiliation: Department of Radiation Oncology, University of Pennsylvania, University of Pennsylvania

Abstract Preview: Purpose: Glioblastomas (GBM) are aggressive and lethal malignancies characterized by their highly refractory nature, contributing to a five-year survival rate of approximately 7%. Physically, GBM exhi...

Retrospective Evaluation of Combined Photon SBRT and Radium-223 SPECT Based Radiopharmaceutical Therapy Tumor Dosimetry in Clinical Trial Patient Cases

Authors: David P. Adam, Allison Cartee, Eric C. Frey, Michael Ghaly, Bin He, Robert Francois Hobbs, Natalie Rose Kania, Ana Kiess, Ian Marsh, Bonnie N. C. President, Steven Rowe, George Sgouros, Phuoc Tran, Hao Wang

Affiliation: Johns Hopkins University, Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Johns Hopkins Medical Institute, Department of Radiation Oncology, University of Maryland School of Medicine, Department of Oncology, Johns Hopkins University, School of Medicine, Department of Radiology, University of North Carolina, Chapel Hill

Abstract Preview: Purpose: Advanced treatment paradigms combining SPECT/CT imageable, alpha emitting, radiopharmaceutical therapy (RPT) and stereotactic body radiotherapy (SBRT) can provide the potential of dose escala...

Robust and Radiobiologically Accurate Dose Summation Strategy for Multiple Courses of Stereotactic Re-Irradiation of Metastatic Brain Cancer Patients with Previous WBRT

Authors: Garrett Russell Hamilton, Joshua Misa, Damodar Pokhrel, William St. Clair

Affiliation: University of Kentucky, Department of Radiation Medicine, University of Kentucky, Radiation Medicine

Abstract Preview: Purpose: Recurrent brain metastasis is very common, and patients who previously received whole-brain radiotherapy (WBRT) may receive an additional course(s) of stereotactic radiosurgery (SRS) to selec...

SRS Treatment Planning for Brain Metastases on Varian Truebeam and Elekta Gamma Knife Icon

Authors: Carl D. Elliston, Lawrence Koutcher, Michael J. Price, Adam C. Riegel, Michael B Sisti, Tony J.C. Wang, Andy (Yuanguang) Xu

Affiliation: Columbia University Irving Medical Center

Abstract Preview: Purpose: An inverse treatment planning software was recently introduced to Gamma Knife radiosurgery. The purpose of this study is to compare the plan quality of the Gamma Knife ”Lightning” with that o...

Standardized Immobilization and Setup Procedure Improves Accuracy of Multi-Time Point SPECT/CT Image Registration for Radiopharmaceutical Therapy (RPT) Dosimetry

Authors: Bryan Bednarz, Laura Bennett, Abby E. Besemer, Tyler J Bradshaw, Steve Y Cho, John M. Floberg, Joseph Grudzinski, Elissa Khoudary, Michael J. Lawless

Affiliation: Department of Radiology, University of Wisconsin, University of Wisconsin-Madison Department of Medical Physics, Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Voximetry, Inc, University of Pennsylvania, Department of Radiology, University of Wisconsin - Madison, Department of Human Oncology, University of Wisconsin-Madison

Abstract Preview: Purpose: To assess the impact of using a standardized immobilization setup for multi-time-point SPECT/CT imaging on radiopharmaceutical therapy (RPT) dosimetry image registration.

Methods: Ten ...

Target Region-Specific Dose-Volume Parameters for Estimate of Brain Toxicity in Single-Isocenter Multiple-Metastases Linac-Based Stereotactic Radiosurgery

Authors: David L. Barbee, Jose R. Teruel Antolin, Jinyu Xue

Affiliation: NYU Langone Health

Abstract Preview: Purpose: This work introduces a method of regional dose evaluation of normal brain tissue using local target-specific evaluation and compares to global dose evaluation for linac-based single-isocenter...

The Impact of a Probabilistic Definition of the Target Volume and Radiobiological Optimization on Complication Probabilities in Proton Therapy

Authors: Ana Maria Barragan Montero, John A. Lee, Eliot Peeters, Romain Schyns, Edmond S. Sterpin, Sophie Wuyckens

Affiliation: UCLouvain, Universite Catholique de Louvain

Abstract Preview: Purpose:
Although the likelihood of a point being tumorous decreases with distance from the GTV, CTVs are still defined as binary masks. Recently, the concept of clinical target distribution (CTD),...

Unsupervised Task-Specific Histology Image Stain Standardization and Crypt Detection for Evaluating Normal Tissue Flash Irradiation Response

Authors: Muhammad Ramish Ashraf, Kerriann Casey, Suparna Dutt, Jie Fu, Edward Elliot Graves, Xuejun Gu, Hao Jiang, Brianna Caroline Lau, Billy W Loo, Weiguo Lu, Rakesh Manjappa, Stavros Melemenidis, Erinn Bruno Rankin, Lawrie Skinner, Luis Armando Soto, Murat Surucu, Vignesh Viswanathan, Zi Yang, Amy Shu-Jung Yu

Affiliation: Department of Radiation Oncology, University of Washington and Fred Hutchinson Cancer Center, Medical Artificial Intelligence and Automation (MAIA) Lab, Department of Radiation Oncology, UT Southwestern Medical Center, UT Southwestern Medical Center, Department of Radiation Oncology, Stanford University School of Medicine, Department of Comparative Medicine, Stanford University School of Medicine, Department of Radiation Oncology, Stanford University Cancer Center

Abstract Preview: Purpose: The intestine is a classical preclinical model for studying radiation injury, and histological quantification of intestinal crypts is a key assay for assessing this response. However, substan...

Volumetric-Modulated Arc Therapy (VMAT) Is Associated with Improved Dose Homogeneity, but More Normal Tissue Irradiation Compared to Three-Dimensional Conformal Radiation Therapy (3DCRT) for Breast Cancer

Authors: Laura I. Cervino, Linda X. Hong, Jessica Pagan, Angelica A. Perez-Andujar, Maria Thor

Affiliation: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer Center, Memorial Sloan-Kettering Cancer Center

Abstract Preview: Purpose: Three-dimensional conformal radiotherapy (3DCRT) and Volumetric-Modulated Arc Therapy (VMAT) are used to treat locally advanced breast cancer. The 3DCRT treatment plans use the treatment fiel...

Voxel-Based Radiobiological Modelling for Evaluating Radiotherapy Treatment Plans in Relation to Radiation-Induced Acute Mucosal Toxicity (including oral and pharyngeal mucositis): A Single-Institutional Study Focused on Head-and-Neck Carcinoma.

Authors: Rama Bhawani, Mary Joan, Ajay Katake, Munish Kumar, Chhape Ram, Megha Sharma, Balbir Singh, Vikram Singh

Affiliation: SLBSGMC & HOSPITAL, MOHANDAI OSWAL HOSPITAL, WOCKHARDT HOSPITAL, Christian Medical College and Hospital,, AMERICAN ONCOLOGY INSTITUTE

Abstract Preview: Purpose: This study aims to evaluate the utility of voxel-based radiobiological modelling in assessing IMRT radiotherapy treatment plans concerning radiation-induced acute mucosal toxicity, specifical...

Voxel-Dose Implications of Single-Compartment Dosimetry for Ablative 90Y-Radioembolization Segmentectomy

Authors: Srinivas Cheenu Kappadath, Benjamin P. Lopez, Armeen Mahvash

Affiliation: UT MD Anderson Cancer Center

Abstract Preview: Purpose: 90Y-radioembolization is utilized with curative intent. While single-compartment doses to the perfused volume for the complete pathologic necrosis (CPN) of tumors have been reported, the actu...

Weak-to-Strong Generalization for Interpretable Deep Learning-Based Histological Image Classification Guided By Hand-Crafted Features

Authors: Mark Anastasio, Zong Fan, Hua Li, Changjie Lu, Lulu Sun, Xiaowei Wang, Zhimin Wang, Michael Wu

Affiliation: University of Illinois at Urbana-Champaign, University of Illinois at Chicago, Washington University School of Medicine, University of Illinois Urbana-Champaign, Washington University in St. Louis, University Laboratory High School

Abstract Preview: Purpose: Histological whole slide images (WSIs) are vital in clinical diagnosis. Although deep learning (DL) methods have achieved great success in this task, they often lack interpretability. Traditi...

Weekly Changes in Ventilation Response for Photon and Proton Patients during Radiotherapy

Authors: Kristy K. Brock, Austin Castelo, Yulun He, Zhongxing Liao, Rebecca Lim, Radhe Mohan, Caleb O'Connor, Tien T Tang, Uwe Titt

Affiliation: University of Washington, The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, The University of Texas MD Anderson Cancer Center

Abstract Preview: Purpose: Conformal dose distributions in proton radiotherapy promise to reduce normal tissue toxicity such as radiation-induced pneumonitis, but this has not been fully realized in clinical trials. To...